百晓学者学者目录

雷群英

副教授、教授、研究员，复旦大学

精选作品

期刊论文

2026

氨基酸信号感知机制进展介绍

尹淼，朱文英，沈院，雷群英

《生命科学》

2026

Malic enzyme 1 senses L-lactate to determine tumor heterogeneity

Siyi Cao, Kewen Hu, Shijing Huang, Xiao-Lin Guan, Jian Wang, Yuan Shen, Hui Ming, Aihong Gu, Chao Wang, Xiao Shen, Qing Wu, Zhengjun Chen, Miao Yin, Wenyu Wen, Qun‐Ying Lei

Signal Transduction and Targeted Therapy

DOI

2026

Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity

Qixiang Ma, Ru Zhao, Jiangxue Han, Wen-Ying Zhu, Mi‐die Xu, Xiao-Yan Zhang, Guoquan Yan, Wenyu Wen, Guang-Chun Han, Min Luo, Miao Yin, Jin-Tao Li, Qun‐Ying Lei

Nature Immunology

DOI

2026

Targeting methionine-induced pyroptosis enhances anti-tumor immunity

Mingzhu Lei, Wenying Zhu, Chao Wang, Fan Zhang, Miaolin Li, Yi Zhang, Jia Qu, Zhiguo Luo, Jintao Li, Zeng-Xia Li, Miao Yin, Qun‐Ying Lei

Science China Life Sciences

DOI

2026

Spatio-temporal metabolic alterations in cachexia

Hui Ming, Miao Yin, Qun‐Ying Lei

Nature Metabolism

DOI

2025

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Yifan Zhang, Xiao Li Shen, Yuan Shen, Chao Wang, Cheng‐Ping Yu, Jiangxue Han, Siyi Cao, Lin Qian, Miaolian Ma, Shijing Huang, Wenyu Wen, Miao Yin, Qun‐Ying Lei

Nature

DOI

2025

BAG2 releases SAMD4B upon sensing of arginine deficiency to promote tumor cell survival

Mengying Chen, Chunyu Sun, Ru Zhao, Xiao-Lin Guan, Miao-Lin Li, Fan Zhang, Zhi-Han Wan, Jing-Xuan Feng, Miao Yin, Qun‐Ying Lei, Qixiang Ma

Molecular Cell

DOI

2025

NUFIP1 integrates amino acid sensing and DNA damage response to maintain the intestinal homeostasis

Hui Ming, Jing Shi Tan, Siyi Cao, Cheng‐Ping Yu, Yuting Qi, Chao Wang, Lei Zhang, Ying Liu, Jian Yuan, Miao Yin, Qun‐Ying Lei

Nature Metabolism

DOI

2024

支链氨基酸代谢在肿瘤发生发展中的作用

沈院，李金涛，尹淼，雷群英

《遗传》

2024

YAP/TAZ mediates resistance to KRAS inhibitors through inhibiting proapoptosis and activating the SLC7A5/mTOR axis

Yang Wang, Ming Zhang, Tian‐Xing Zhang, Jiahui Liu, Man-Wei Hao, Yan Xu, Haicheng Gao, Qun‐Ying Lei, Jiuwei Cui, Xin Zhou

JCI Insight

DOI

2024

ER-associated degradation ligase HRD1 links ER stress to DNA damage repair by modulating the activity of DNA-PKcs

Zhiyuan Xiang, Guixue Hou, Shanliang Zheng, Minqiao Lu, Tianyu Li, Qingyu Lin, Hao Liu, Xingwen Wang, Tianqi Guan, Yuhan Wei, Wenxin Zhang, Yi Zhang, Chaoran Liu, Li Li, Qun‐Ying Lei, Ying Hu

Proceedings of the National Academy of Sciences

DOI

2024

Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration

Ruiqian Zhao, Shijing Huang, Jingyu Li, Aihong Gu, Minjie Fu, Wei Hua, Ying Qing Mao, Qun‐Ying Lei, Boxun Lu, Wenyu Wen

The Journal of Cell Biology

DOI

2024

Targeting stromal metabolism in pancreatic ductal adenocarcinoma

Miao Yin, Qun‐Ying Lei

Nature Cell Biology

DOI

2024

ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation

Yuan Shen, Liang-Liang Zheng, Cai-Yun Fang, Yaoyao Xu, Chao Wang, Jin-Tao Li, Mingzhu Lei, Miao Yin, Haojie Lu, Qun‐Ying Lei, Jia Qu

Cell Reports

DOI

2023

代谢酶的非经典功能及代谢感知

雷群英

《生命的化学》

2023

Publisher Correction: TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Jing He, Mingen Lin, Xinchao Zhang, Ruonan Zhang, Tongguan Tian, Yuefan Zhou, Wenjing Dong, Yajing Yang, Xue Sun, Yue Dai, Yue Xu, Yue Xu, Zhenru Zhang, Ming Xu, Qun‐Ying Lei, Yanping Xu, Yanping Xu, Lei Lv

Cell Discovery

DOI

2023

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential

Jing He, Mingen Lin, Xinchao Zhang, Ruonan Zhang, Tongguan Tian, Yuefan Zhou, Wenjing Dong, Yajing Yang, Xue Sun, Yue Dai, Yue Xu, Yue Xu, Zhenru Zhang, Ming Xu, Qun‐Ying Lei, Yanping Xu, Yanping Xu, Lei Lv

Cell Discovery

DOI

2023

Feedback regulation of ubiquitination and phase separation of HECT E3 ligases

Jingyu Li, Kang Zhu, Aihong Gu, Yiqing Zhang, Shijing Huang, Ronggui Hu, Weiguo Hu, Qun‐Ying Lei, Wenyu Wen

Proceedings of the National Academy of Sciences

DOI

2023

Aldolase A Accelerates Cancer Progression by Modulating mRNA Translation and Protein Biosynthesis via Noncanonical Mechanisms

Junjiao Song, Hongquan Li, Yanfang Liu, Xinrong Li, Qili Shi, Qun‐Ying Lei, Weiguo Hu, Shenglin Huang, Zhiao Chen, Xianghuo He

Advanced Science

DOI

2023

Increased α-HB links colorectal cancer and diabetes by potentiating NF-κB signaling

Xinyue Lv, Peipei Ding, Luying Li, Ling Li, Danlei Zhou, Xiaochao Wang, Jianfeng Chen, Wei Zhang, Qi Wang, Tian Liao, Wenyu Wen, Dawang Zhou, Qinghai Ji, Xianghuo He, Qun‐Ying Lei, Weiguo Hu

Molecular Metabolism

DOI

2023

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression

Qian Lin, Na Li, Xiaochen Lu, Midie Xu, Ying Liu, Kaiyue Li, Yi qin Zhang, Kewen Hu, Yu-Ting Qi, Jun Yao, Yingli Wu, Wenyu Wen, Shenglin Huang, Zhengjun Chen, Miao Yin, Qun‐Ying Lei

Nature Metabolism

DOI

2023

A metabolic clue for STING suppression

Yifan Zhang, Mingzhu Lei, Miao Yin, Qun‐Ying Lei

Trends in Cell Biology

DOI

2023

Data from TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun‐Ying Lei, Jing Zhang, Qing Hua Zhang, Yanping Xu, Lei Lv

DOI

2023

Supplementary Data and Methods from ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Cuicui Liu, Jiankun Qiang, Qiaodan Deng, Jie Lai Xia, Lu Deng, Lei Zhou, Dong Wang, Xueyan He, Ying Liu, Botao Zhao, Jinhui Lv, Zuoren Yu, Qun‐Ying Lei, Zhi‐Ming Shao, Xiao‐Yong Zhang, Lixing Zhang, Suling Liu

DOI

2023

Data from ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Cuicui Liu, Jiankun Qiang, Qiaodan Deng, Jie Lai Xia, Lu Deng, Lei Zhou, Dong Wang, Xueyan He, Ying Liu, Botao Zhao, Jinhui Lv, Zuoren Yu, Qun‐Ying Lei, Zhi‐Ming Shao, Xiao‐Yong Zhang, Lixing Zhang, Suling Liu

DOI

2023

S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency

Miao-Lin Li, Siyi Cao, Jia Qu, Lei Zhang, Qiang Gao, Xu Wang, Miao Yin, Ying Liu, Mingzhu Lei, Qun‐Ying Lei

Development

DOI

2022

Correction To: Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Jintao Li, Hai Zhen Yang, Mingzhu Lei, Weiping Zhu, Ying Su, Kai-Yue Li, Wen-Ying Zhu, Jian Wang, Lei Zhang, Jia Qu, Lei Lv, Haojie Lu, Zhengjun Chen, Lu Wang, Miao Yin, Qun‐Ying Lei

Signal Transduction and Targeted Therapy

DOI

2022

BCAT2–BCKDH metabolon maintains BCAA homeostasis

Miao Yin, Qun‐Ying Lei

Nature Metabolism

DOI

2022

Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA

Jintao Li, Hai Zhen Yang, Mingzhu Lei, Weiping Zhu, Ying Su, Kai-Yue Li, Wen-Ying Zhu, Jian Wang, Lei Zhang, Jia Qu, Lei Lv, Haojie Lu, Zhengjun Chen, Lu Wang, Miao Yin, Qun‐Ying Lei

Signal Transduction and Targeted Therapy

DOI

2022

CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid β‐Oxidation Pathway

Hongquan Li, Junjiao Song, Yifei He, Yizhe Liu, Zhen Liu, Weili Sun, Weiguo Hu, Qun‐Ying Lei, Xin Hu, Zhiao Chen, Xianghuo He

Advanced Science

DOI

2022

Intracellular complement C5a/C5aR1 stabilizes β-catenin to promote colorectal tumorigenesis

Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qinghai Ji, Qun‐Ying Lei, Weiguo Hu

Cell Reports

DOI

2022

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

Fan Zhang, Di Wang, Jintao Li, Ying Su, Suling Liu, Qun‐Ying Lei, Miao Yin

Journal of Molecular Cell Biology

DOI

2022

Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth

Xuan Pei, Kai-Yue Li, Yuan Shen, Jin-Tao Li, Mingzhu Lei, Caiyun Fang, Haojie Lu, Huijuan Yang, Wenyu Wen, Miao Yin, Jia Qu, Qun‐Ying Lei

Science China Life Sciences

DOI

2022

A pathway-guided strategy identifies a metabolic signature for prognosis prediction and precision therapy for hepatocellular carcinoma

Qili Shi, Yizhe Liu, Mingxing Lu, Qun‐Ying Lei, Zhiao Chen, Lu Wang, Xianghuo He

Computers in Biology and Medicine

DOI

2022

D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1

Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun‐Ying Lei, Song Zhang, Yanping Xu, Lei Lv

Proceedings of the National Academy of Sciences

DOI

2022

TET2 Suppresses VHL Deficiency-Driven Clear Cell Renal Cell Carcinoma by Inhibiting HIF Signaling

Xinchao Zhang, Shuyan Li, Jing He, Yunjie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun‐Ying Lei, Jing Zhang, Qing Hua Zhang, Yanping Xu, Lei Lv

Cancer Research

DOI

2022

BCAA–BCKA axis regulates WAT browning through acetylation of PRDM16

Qixiang Ma, Wen-Ying Zhu, Xiaochen Lu, Duo Jiang, Feng Xu, Jintao Li, Lei Zhang, Yingli Wu, Zhengjun Chen, Miao Yin, Haiyan Huang, Qun‐Ying Lei

Nature Metabolism

DOI

2021

代谢应激和胰腺癌的发生发展

李金涛，雷明珠，雷群英，尹淼

《四川大学学报(医学版)》

2021

Cancer metabolism and dietary interventions

Lin Qian, Fan Zhang, Miao Yin, Qun‐Ying Lei

Cancer Biology and Medicine

DOI

2021

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

Jintao Li, Kai-Yue Li, Ying Su, Yuan Shen, Mingzhu Lei, Fan Zhang, Miao Yin, Zhengjun Chen, Wenyu Wen, Weiguo Hu, Dan Su, Jia Qu, Qun‐Ying Lei

National Science Review

DOI

2021

TEM8 marks neovasculogenic tumor-initiating cells in triple-negative breast cancer

Jiahui Xu, Xiaoli Yang, Qiaodan Deng, Cong Yang, Dong Wang, Guojuan Jiang, Xiaohong Yao, Xueyan He, Jiajun Ding, Jiankun Qiang, Juchuanli Tu, Rui Zhang, Qun‐Ying Lei, Zhimin Shao, Xiu‐Wu Bian, Ronggui Hu, Lixing Zhang, Suling Liu

Nature Communications

DOI

2021

AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner

Wei Huang, Na Li, Yi qin Zhang, Xu Wang, Miao Yin, Qun‐Ying Lei

Autophagy

DOI

2021

Proteins moonlighting in tumor metabolism and epigenetics

Lei Lv, Qun‐Ying Lei

Frontiers of Medicine

DOI

2021

[A Review of Metabolic Stress and Development of Pancreatic Cancer].

Jintao Li, Mingzhu Lei, Qun‐Ying Lei, Miao Yin

PubMed

DOI

2020

FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis

Wei Zhang, Xin Zhang, Sheng Huang, Jianfeng Chen, Peipei Ding, Qi Wang, Luying Li, Xinyue Lv, Ling Li, Pingzhao Zhang, Danlei Zhou, Wenyu Wen, Yiping Wang, Qun‐Ying Lei, Jiong Wu, Weiguo Hu

Molecular Oncology

DOI

2020

Metabolite sensing and signaling in cancer

Yi-Ping Wang, Jintao Li, Jia Qu, Miao Yin, Qun‐Ying Lei

Journal of Biological Chemistry

DOI

2020

Rewiring local immune milieu by boosting dendritic cell for pancreatic cancer treatment

Yifan Zhang, Qun‐Ying Lei

Signal Transduction and Targeted Therapy

DOI

2020

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Mingzhu Lei, Xu-Xu Li, Ye Zhang, Jin-Tao Li, Fan Zhang, Yi-Ping Wang, Miao Yin, Jia Qu, Qun‐Ying Lei

Signal Transduction and Targeted Therapy

DOI

2020

Par complex cluster formation mediated by phase separation

Ziheng Liu, Ying Yang, Aihong Gu, Jiawen Xu, Ying Qing Mao, Haojie Lu, Weiguo Hu, Qun‐Ying Lei, Zhouhua Li, Mingjie Zhang, Yu Cai, Wenyu Wen

Nature Communications

DOI

2020

Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival

Jizheng Guo, Qixiang Zhang, Ying Su, Xiaochen Lu, Yiping Wang, Miao Yin, Weiguo Hu, Wenyu Wen, Qun‐Ying Lei

Science China Life Sciences

DOI

2020

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Jintao Li, Miao Yin, Di Wang, Jian Wang, Mingzhu Lei, Ye Zhang, Ying Liu, Lei Zhang, Shaowu Zou, Li-Peng Hu, Zhigang Zhang, Yiping Wang, Wenyu Wen, Haojie Lu, Zhengjun Chen, Dan Su, Qun‐Ying Lei

Nature Cell Biology

DOI

2020

C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation

Peipei Ding, Ling Li, Luying Li, Xinyue Lv, Danlei Zhou, Qingkai Wang, Jianfeng Chen, Chaoqun Yang, Enjie Xu, Weixing Dai, Xin Zhang, Na Wang, Qi Wang, Wei Zhang, Long Zhang, Yuzhen Zhou, Hongyu Gu, Qun‐Ying Lei, Xuhui Zhou, Weiguo Hu

Theranostics

DOI

2020

PI3K/AKT inhibition reverses R-CHOP resistance by destabilizing SOX2 in diffuse large B cell lymphoma

Jianfeng Chen, Xiaowen Ge, Wei Zhang, Peipei Ding, Yiqun Du, Qi Wang, Ling Li, Lan Fang, Yujing Sun, Pingzhao Zhang, Yuzhen Zhou, Long Zhang, Xinyue Lv, Luying Li, Xin Zhang, Qunling Zhang, Kai Xue, Hongyu Gu, Qun‐Ying Lei, Jiemin Wong, Weiguo Hu

Theranostics

DOI

2019

代谢物感受与信号传递

王义平，雷群英

《中国细胞生物学学报》

2019

编者按

雷群英

《中国细胞生物学学报》

2019

Metabolism remodeling in pancreatic ductal adenocarcinoma

Jintao Li, Yi-Ping Wang, Miao Yin, Qun‐Ying Lei

Cell Stress

DOI

2019

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases

Zhen Wang, Ziheng Liu, Xing Chen, Jingyu Li, Weiyi Yao, Shijing Huang, Aihong Gu, Qun‐Ying Lei, Ying Qing Mao, Wenyu Wen

Nature Communications

DOI

2018

赖氨酸乙酰化调控细胞代谢的机制

王义平，雷群英

《生命科学》

2018

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis

Weiwei Yan, Yun‐Liu Liang, Qixiang Zhang, Di Wang, Mingzhu Lei, Jia Qu, Xianghuo He, Qun‐Ying Lei, Yiping Wang

EMBO Reports

DOI

2018

Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

Yuan Liu, Jizheng Guo, Ying Liu, Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu, Shengtao Zhou, Xiaochen Lu, Hongbin Yang, Chenyue Xu, Wei Qiang Gao, Li Zhou, Yi-Ping Wang, Weiguo Hu, Yuquan Wei, Canhua Huang, Qun‐Ying Lei

Nature Communications

DOI

2018

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer

Xing-Yu Zhong, Xiu-Ming Yuan, Yingying Xu, Miao Yin, Weiwei Yan, Shaowu Zou, Liming Wei, Haojie Lu, Yi-Ping Wang, Qun‐Ying Lei

Cell Reports

DOI

2018

TAZQ233del Hijacks Hippo pathway to promote mesenchymal-epithelial transition in pancreatic adenocarcinoma cells

Chuan-Bo Yao, Min Zhang, Xin Zhou, Qun‐Ying Lei, Miao Yin

Biochemical and Biophysical Research Communications

DOI

2018

Metabolic recoding of epigenetics in cancer

Yi‐Ping Wang, Qun‐Ying Lei

《癌症：英文版》

DOI

2017

微环境调控肿瘤代谢的研究

尹淼，李金涛，王义平，雷群英

《生物化学与生物物理进展》

2017

3D虚拟技术在生物化学实验教学中的应用探讨

李增霞，王丽影，雷群英，汤其群

《基础医学教育》

2017

胰腺癌通过调控非经典谷氨酰胺代谢维持氧化还原稳态

王义平，雷群英

《中国细胞生物学学报》

2017

精氨酸甲基转移酶CARM1通过甲基化苹果酸脱氢酶MDH1降低谷氨酰胺代谢并抑制胰腺癌

王义平，Wei Zhou，Jian Wang，Xian Huang，Yong Zuo，Tian-Shi Wang，Xue Gao，Ying-Ying Xu，Shao-Wu Zou，Ying-Bin Liu，程金科，雷群英

《科学新闻》

2017

Hippo信号通路在乳腺癌中的调控机制及作用

姚传波，周鑫，陈策实，雷群英

《遗传》

2017

NOTCH1 Signaling Regulates Self-Renewal and Platinum Chemoresistance of Cancer Stem–like Cells in Human Non–Small Cell Lung Cancer

Yun Zhang, Wei Xu, Huiqin Guo, Yanmei Zhang, Yuexi He, Sau Har Lee, Xin Song, Xiaoyan Li, Yongqing Guo, Yunlong Zhao, Cheng Ding, Fei Ning, Yuanyuan Ma, Qun‐Ying Lei, Xiaoyu Hu, Shengnan Li, Wei Guo

Cancer Research

DOI

2017

Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone

Ye Zhang, Yingying Xu, Chuan-Bo Yao, Jin-Tao Li, Xiangning Zhao, Hongbin Yang, Min Zhang, Miao Yin, Jing Chen, Qun‐Ying Lei

Autophagy

DOI

2016

糖代谢异常与肿瘤发生发展

徐莺莺，王健，雷群英

《中国生化药物杂志》

2016

细胞代谢异常与肿瘤发生发展

周鑫，王义平，徐莺莺，雷群英

《生命的化学》

DOI

2016

G蛋白beta亚基调控GRK2泛素化的新功能研究

查正宇，Xiaoran Han，Matthew D.Smith，Yang Liu，Patrick M.Gigu è re，Dragana Kopanja，Pradip Raychaudhuri，David P.Siderovski，管坤良，雷群英，熊跃

《科学新闻》

2016

Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth

Jun Fan, Ruiting Lin, Siyuan Xia, Dong Chen, Shannon Elf, Shuangping Liu, Yaozhu Pan, Haidong Xu, Zhiyu Qian, Mei Wang, Changliang Shan, Lu Zhou, Qun‐Ying Lei, Yuancheng Li, Hui Z. Mao, Benjamin H. Lee, Jessica Sudderth, Ralph J. DeBerardinis, Guojing Zhang, Taofeek Kunle Owonikoko, Manila Gaddh, Martha Lucia Arellano, Hanna Jean Khoury, Fadlo Raja Khuri, Sumin Kang, Paul W. Doetsch, Sagar Lonial, Titus J. Boggon, Walter John Curran, Jing Chen

Molecular Cell

DOI

2016

Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer

Yi-Ping Wang, Wei Zhou, Jian Wang, Xian Huang, Yong Zuo, Tian-Shi Wang, Xue Jun Gao, Yingying Xu, Shaowu Zou, Yingbin Liu, Jinke Cheng, Qun‐Ying Lei

Molecular Cell

DOI

2016

Regulation of TAZ in cancer

Xin Zhou, Qun‐Ying Lei

Protein & Cell

DOI

2016

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Xue Jun Gao, Shuhai Lin, Feng Ren, Jin-Tao Li, Jia-Jia Chen, Chuan-Bo Yao, Hongbin Yang, Shu-Xia Jiang, Guo-Quan Yan, Di Wang, Yiping Wang, Ying Liu, Zongwei Cai, Ying-Ying Xu, Jing Chen, Wenqiang Yu, Pengyuan Yang, Qun‐Ying Lei

Nature Communications

DOI

2016

Cullin 3 targets methionine adenosyltransferase IIα for ubiquitylation‐mediated degradation and regulates colorectal cancer cell proliferation

Jian Wang, Zi‐Hua Zhu, Hongbin Yang, Ye Zhang, Xiang‐Ning Zhao, Min Zhang, Yingbin Liu, Yingying Xu, Qun‐Ying Lei

FEBS Journal

DOI

2015

乙酰化对代谢的调控及其在代谢相关疾病中的作用

王义平，雷群英

《中国科学:生命科学》

2015

6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling

Ruiting Lin, Shannon Elf, Changliang Shan, Hee‐Bum Kang, Quanjiang Ji, Lu Zhou, Taro Hitosugi, Liang Zhang, Shuai Zhang, Jae Ho Seo, Jianxin Xie, Meghan Tucker, Ting-Lei Gu, Jessica Sudderth, Lei Jiang, Matthew A. Mitsche, Ralph J. DeBerardinis, Shaoxiong Wu, Yuancheng Li, Hui Z. Mao, Peng R. Chen, Dongsheng Wang, Georgia Zhuo Chen, Selwyn J. Hurwitz, Sagar Lonial, Martha Lucia Arellano, Hanna Jean Khoury, Fadlo Raja Khuri, Benjamin H. Lee, Qun‐Ying Lei, Daniel Jay Brat, Keqiang Ye, Titus J. Boggon, Chuan He, Sumin Kang, Jun Fan, Jing Chen

Nature Cell Biology

DOI

2015

PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction

Xianbo Lv, Chen‐Ying Liu, Zhen Wang, Yi‐Ping Sun, Yue Xiong, Qun‐Ying Lei, Kun‐Liang Guan

EMBO Reports

DOI

2015

Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer

Hongbin Yang, Yingying Xu, Xiangning Zhao, Shaowu Zou, Ye Zhang, Min Zhang, Jin-Tao Li, Feng Ren, Liying Wang, Qun‐Ying Lei

Nature Communications

DOI

2015

Estrogen regulates Hippo signaling via GPER in breast cancer

Xin Zhou, Shuyang Wang, Zhen Wang, Xu Feng, Peng Liu, Xian-Bo Lv, Fulong Li, Fa‐Xing Yu, Yiping Sun, Hai‐Xin Yuan, Hongguang Zhu, Yue Xiong, Qun‐Ying Lei, Kun‐Liang Guan

Journal of Clinical Investigation

DOI

2014

NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells

Di Zhao, Yan Mo, Meng-Tian Li, Shaowu Zou, Zhou‐Li Cheng, Yi-Ping Sun, Yue Xiong, Kun‐Liang Guan, Qun‐Ying Lei

Journal of Clinical Investigation

DOI

2014

Impact of acetylation on tumor metabolism

Di Zhao, Fu-Long Li, Zhou‐Li Cheng, Qun‐Ying Lei

Molecular & Cellular Oncology

DOI

2014

Acetylation Control of Cancer Cell Metabolism

Ruiting Lin, Xin Zhou, Wei Huang, Di Zhao, Lei Lv, Yue Xiong, Kun‐Liang Guan, Qun‐Ying Lei

Current Pharmaceutical Design

DOI

2013

p300-Dependent Acetylation of Activating Transcription Factor 5 Enhances C/EBPβ Transactivation of C/EBPα during 3T3-L1 Differentiation

Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun‐Ying Lei, Qi-Qun Tang, Xi Li

Molecular and Cellular Biology

DOI

2013

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

Ruiting Lin, Tao Ren, Xue Jun Gao, Tingting Li, Xin Zhou, Kun‐Liang Guan, Yue Xiong, Qun‐Ying Lei

Molecular Cell

DOI

2013

LDH-A Acetylation: Implication in Cancer

Di Zhao, Yue Xiong, Qun‐Ying Lei, Kun‐Liang Guan

Oncotarget

DOI

2013

Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment

Hai-Yan Huang, Su-Zhen Chen, Wen-Ting Zhang, Shanshan Wang, Yang Liu, Xi Li, Xia Sun, Yi-Ming Li, Bo Wen, Qun‐Ying Lei, Qi-Qun Tang

Stem Cell Research

DOI

2012

The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition

Wei Huang, Xianbo Lv, Chen‐Ying Liu, Zhengyu Zha, Heng Zhang, Ying Jiang, Yue Xiong, Qun‐Ying Lei, Kun‐Liang Guan

Journal of Biological Chemistry

DOI

2011

Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage

Xin Zhou, Ting-Ting Li, Xu Feng, Esther Y. Hsiang, Yue Xiong, Kun‐Liang Guan, Qun‐Ying Lei

Biochemical Journal

DOI

2011

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

Wenqing Jiang, Shiwen Wang, Mengtao Xiao, Yan Lin, Lisha Zhou, Qun‐Ying Lei, Yue Xiong, Kun‐Liang Guan, Shimin Zhao

Molecular Cell

DOI

2011

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se Hee Kim, Shinsuke Ito, Yang Chen, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen V. Frye, Yi Zhang, Yan-hui Xu, Qun‐Ying Lei, Kun‐Liang Guan, Shimin Zhao, Yue Xiong

Cancer Cell

DOI

2010

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

Chen‐Ying Liu, Zhengyu Zha, Xin Zhou, Heng Zhang, Wei Huang, Di Zhao, Tingting Li, Siew Wee Chan, Chun Jye Lim, Wanjin Hong, Shimin Zhao, Yue Xiong, Qun‐Ying Lei, Kun‐Liang Guan

Journal of Biological Chemistry

DOI

2010

Regulation of Cellular Metabolism by Protein Lysine Acetylation

Shimin Zhao, Wei Xu, Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M. Hancock, Fuchu He, Lun–Xiu Qin, Jason W. Chin, Pengyuan Yang, Xian Chen, Qun‐Ying Lei, Yue Xiong, Kun‐Liang Guan

Science

DOI

2009

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Shimin Zhao, Yan Lin, Wei Xu, Wenqing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Ling-Ling Gong, Yingjie Peng, Jianping Ding, Qun‐Ying Lei, Kun‐Liang Guan, Yue Xiong

Science

DOI

2009

Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals

Wei Yu, Yan Lin, Jun Yao, Wei Huang, Qun‐Ying Lei, Yue Xiong, Shimin Zhao, Kun‐Liang Guan

Journal of Biological Chemistry

DOI

2008

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

Qun‐Ying Lei, Heng Zhang, Bin Zhao, Zhengyu Zha, Feng Bai, Xin‐Hai Pei, Shimin Zhao, Yue Xiong, Kun‐Liang Guan

Molecular and Cellular Biology

DOI

2002

N-乙酰氨基葡萄糖转移酶Ⅴ过表达对人肝癌细胞粘着斑复合物介导的信号转导作用

王丽影，雷群英，戴振宇，陈伉俪，陈惠黎，查锡良

《中国生物化学与分子生物学报》

2002

人肺癌细胞抑癌基因PTEN的表达与失巢凋亡的关系

雷群英，王丽影，戴振宇，查锡良

Acta Biochimica et Biophysica Sinica

2000

TGF-β1短时处理降低肝癌细胞与Fn的粘附及FAK的磷酸化

蔡婷，雷群英，查锡良

《分子细胞生物学报》

会议论文

2016

Acetylation Control of Lipid Synthesis

雷群英

《中国生物化学与分子生物学会2016年全国学术会议》

2014

Acetylation control of metabolic enzymes in cancer

Qunying Lei

《中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议论文集——专题报告三》

2011

乳酸脱氢酶A的乙酰化调控及其在胰腺癌的发展中的作用

赵地，邹邵武，刘颖，熊跃，管坤良，雷群英

《第七届全国医学生物化学与分子生物学和第四届全国临床应用生物化学与分子生物学联合学术研讨会暨医学生化分会会员代表大会》

2003

β1族整合蛋白过表达对人肝癌细胞细胞周期的调控及其机制研究

梁玉龙，雷霆雯，吴衡，苏剑敏，王丽影，雷群英，查锡良

《华东六省一市生物化学与分子生物学会2003年学术交流会论文摘要集》

预印本

2019

PI3K/AKT inhibition in tumor propagating cells of DLBCL reverses R-CHOP resistance by destabilizing SOX2

Jianfeng Chen, Xiaowen Ge, Wei Zhang, Peipei Ding, Yiqun Du, Qi Wang, Ling Li, Lan Fang, Yujing Sun, Pingzhao Zhang, Yuzhen Zhou, Long Zhang, Xinyue Lv, Luying Li, Xin Zhang, Qunling Zhang, Kai Xue, Hongyu Gu, Qun‐Ying Lei, Jiemin Wong, Weiguo Hu

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2011

Regulation of Glycolysis and Gluconeogenesis by Acetylation of PKM and PEPCK

Yue Xiong, Qun‐Ying Lei, Shimin Zhao, Kun‐Liang Guan

Cold Spring Harbor Symposia on Quantitative Biology

DOI

书籍章节

2017

Perspectives of Reprogramming Breast Cancer Metabolism

Yi-Ping Wang, Qun‐Ying Lei

Advances in experimental medicine and biology

DOI

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