郭聪｜上海大学｜学者主页

期刊论文

2026

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α-Synuclein Phase Separation

Zhongyuan Yang, Yiming Tang, Jitao Wen, Cong Guo, Yun Zhou, Zihan Wang, Tong Pan, Yuan Tan, Sarah Perrett, Si Wu, Guanghong Wei

JACS Au

DOI

2025

Insights into the coaggregation mechanisms of amyloid-α and amyloid-β

Zhengyu Xu, Xingke Yan, Pengxuan Xia, Yanyan Zhu, Yujie Chen, Cong Guo, Huiyu Li

International Journal of Biological Macromolecules

DOI

2025

Molecular Dynamics Simulations Reveal Conformational Determinants of the Dynamic Association between α-Synuclein and Membranes

Jiahui Huang, Cong Guo

Journal of Chemical Information and Modeling

DOI

2025

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau (Small 6/2025)

Yujie Chen, Xun Sun, Yiming Tang, Yuan Tan, Cong Guo, Tong Pan, Xuefeng Zhang, Jinghui Luo, Guanghong Wei

Small

DOI

2024

蛋白质结构标注中的基于支持向量机的拉氏图优化方法

王博，苏天昊，徐妍婷，高恒，郭聪，李永乐，吴伟

《上海大学学报(自然科学版)》

2024

从蛋白质环境引起的实际变化中剖析配体结构的误差

乔琳琳，李永乐，郭聪，BICZYSKO Malgorzata

《上海大学学报(自然科学版)》

2024

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau

Yujie Chen, Xun Sun, Yiming Tang, Yuan Tan, Cong Guo, Tong Pan, Xuefeng Zhang, Jinghui Luo, Guanghong Wei

Small

DOI

2024

Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides

Zenghui Lao, Yiming Tang, Xuewei Dong, Yuan Tan, Xuhua Li, Xianshi Liu, Le Li, Cong Guo, Guanghong Wei

Nanoscale

DOI

2024

Simulations of a PKA RIα homodimer reveal cAMP-coupled conformational dynamics of each protomer and the dimer interface with functional implications

Xin Chen, Cong Guo

Physical Chemistry Chemical Physics

DOI

2023

E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation

Defa Huang, Cong Guo

Journal of Chemical Information and Modeling

DOI

2022

Concentration-Dependent Effects of Cholesterol on the Dimerization of Amyloid-β Peptides in Lipid Bilayers

Bin Wang, Cong Guo

ACS Chemical Neuroscience

DOI

2021

Multipronged Regulatory Functions of Serum Albumin in Early Stages of Amyloid-β Aggregation

Mengjuan Zhao, Cong Guo

ACS Chemical Neuroscience

DOI

2021

Albumin Alters the Conformational Ensemble of Amyloid-β by Promiscuous Interactions: Implications for Amyloid Inhibition

Huisi Xie, Cong Guo

Frontiers in Molecular Biosciences

DOI

预印本

2026

Quantum-Circuit Residuals for Receptor Functional Potency Prediction: Predictive Gains and Quadratic Structure

Chenyan Jia, Yaping Ma, Yuen Wang, Cong Guo

arXiv preprint

郭聪

精选作品

期刊论文

Pathological Mutation E46K Acts as an Electrostatic Switch to Increase Distant Interdomain Interactions and Promote α-Synuclein Phase Separation

Insights into the coaggregation mechanisms of amyloid-α and amyloid-β

Molecular Dynamics Simulations Reveal Conformational Determinants of the Dynamic Association between α-Synuclein and Membranes

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau (Small 6/2025)

蛋白质结构标注中的基于支持向量机的拉氏图优化方法

从蛋白质环境引起的实际变化中剖析配体结构的误差

Pathogenic Mutation ΔK280 Promotes Hydrophobic Interactions Involving Microtubule‐Binding Domain and Enhances Liquid‐Liquid Phase Separation of Tau

Elucidating the reversible and irreversible self-assembly mechanisms of low-complexity aromatic-rich kinked peptides and steric zipper peptides

Simulations of a PKA RIα homodimer reveal cAMP-coupled conformational dynamics of each protomer and the dimer interface with functional implications

E46K Mutation of α-Synuclein Preorganizes the Intramolecular Interactions Crucial for Aggregation

Concentration-Dependent Effects of Cholesterol on the Dimerization of Amyloid-β Peptides in Lipid Bilayers

Multipronged Regulatory Functions of Serum Albumin in Early Stages of Amyloid-β Aggregation

Albumin Alters the Conformational Ensemble of Amyloid-β by Promiscuous Interactions: Implications for Amyloid Inhibition

预印本

Quantum-Circuit Residuals for Receptor Functional Potency Prediction: Predictive Gains and Quadratic Structure

研究方向