吕建明｜暨南大学｜学者主页

2026

Unraveling stereochemical control mechanisms of neuroactive securinine via isotope-guided spatial transcriptomic strategy

Lu Dong, Ying Wang, Jian‐Ming Lv, Lijun Hu, Guanqiu Qin, Run Yang, Zhenlong Wu, Gaoqian Wang, Shaoyang Li, Chuanxi Wang, Yifang Li, Guodong Chen, Dan Hu, Wencai Ye, Ikuro Abe, Hao Gao

Acta Pharmaceutica Sinica B

DOI

2026

Structural and catalytic mechanisms of two N-hydroxycinnamoyltransferases underlying lycibarbarspermidines biosynthesis in wolfberry

Shao-Yang Li, Jia-Cheng Huang, Ya-Lin Wang, Hong-Ting Zhen, Yu Fan, Zheng-Qun Zhou, G Chen, Jian‐Ming Lv, Gao‐Qian Wang, Dan Hu, Hao Gao

Chinese Chemical Letters

DOI

2026

Biosynthesis of Xyloketals: Furanochromene Skeleton Formed via Heterodimerization of Two Orsellinic Acid-Branched Metabolites

Jia-Hua Huang, Jian‐Ming Lv, Yue Qi, Qian Xu, Fu-Long Lin, Gao‐Qian Wang, Shao-Yang Li, Ping Dai, Xue-Feng Bao, Wen-Tao Chen, Guo‐Dong Chen, Takayoshi Awakawa, Dan Hu, Ikuro Abe, Hao Gao

Journal of the American Chemical Society

DOI

2026

Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

Yue Liu, Zhuo-Jia Gan, Zhong-Yuan Zhang, Huan Zhao, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Takayoshi Awakawa, Cao Zhi-qin, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2026

Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension

Yao-Hui Gao, Xiao Pan, Qin-Lian Wang, Xue-Feng Bao, Ping Dai, Sheng-Ying Qin, Shao-Yang Li, Guo‐Dong Chen, Gao‐Qian Wang, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2025

Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

Pan Luo, Jian‐Ming Lv, Hong-Ting Zhen, Ying-Qi Zhao, Jing-Yuan Liu, Jin-Yu Hong, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Shuixing Zhang, Dan Hu, Hao Gao

Chinese Chemical Letters

DOI

2025

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Yaohui Gao, Jian‐Ming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gao‐Qian Wang, Shao-Yang Li, Guo‐Dong Chen, Dan Hu, Hao Gao, Xin‐Sheng Yao

Advanced Science

DOI

2025

Generation of two novel furanosteroids via heterologous expression of demethoxyviridin biosynthetic genes in a wortmannin-producing strain

Wei Jiang, Linhuan Li, Lin-Min Zhang, Huan Zhao, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2024

A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process

Jing-Yuan Liu, Fu-Long Lin, Kizerbo A. Taizoumbe, Jian‐Ming Lv, Yongheng Wang, Gao‐Qian Wang, Guodong Chen, Xin‐Sheng Yao, Dan Hu, Hao Gao, Jeroen S. Dickschat

Angewandte Chemie International Edition

DOI

2024

Ein funktioneller Wechsel zwischen Asperfumen‐ und Fusicoccadien‐Synthase und Eintritt in die Asperfumen‐Biosynthese durch einen vicinalen Deprotonierungs‐Reprotonierungsprozess

Jing‐Yuan Liu, Fu-Long Lin, Kizerbo A. Taizoumbe, Jian‐Ming Lv, Yongheng Wang, Gao‐Qian Wang, Guo‐Dong Chen, Xin‐Sheng Yao, Dan Hu, Hao Gao, Jeroen S. Dickschat

Angewandte Chemie

DOI

2024

Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

Shao-Yang Li, Gao‐Qian Wang, Liang Long, Jia-Ling Gao, Zheng-Qun Zhou, Yongheng Wang, Jian‐Ming Lv, Guo‐Dong Chen, Dan Hu, Ikuro Abe, Hao Gao

Nature Communications

DOI

2024

Targeted Discovery of a Natural ortho-Quinone Methide Precursor and Green Generation of Its Oligomers

Xiaoxia Wang, Bei-Qian Deng, Zhi-Qiu Ouyang, Yan Yang, Jian‐Ming Lv, Sheng-Ying Qin, Dan Hu, Guo‐Dong Chen, Xin‐Sheng Yao, Hao Gao

Journal of Natural Products

DOI

2024

Identification of three novel P450 enzymes involved in the oxidative modification of a newly discovered fusicoccane diterpene

Dong Lu, Jing-Yuan Liu, Gao‐Qian Wang, Pan Luo, Jia-Hua Huang, Jian‐Ming Lv, Guo‐Dong Chen, Weibin Cheng, Junzhang Tian, Fu-Long Lin, Dan Hu, Hao Gao

Bioorganic Chemistry

DOI

2024

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage

Zhiqin Cao, Gao‐Qian Wang, Rui Luo, Yaohui Gao, Jian‐Ming Lv, Sheng-Ying Qin, Guo‐Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qinghua Mei, Xin‐Sheng Yao, Dan Hu, Ikuro Abe, Hao Gao

Journal of the American Chemical Society

DOI

2024

Absolute Configuration of Oxabornyl Polyenes Prugosenes A1–A3 and Structural Revision of Prugosene A2

Fu-Long Lin, Jia-Ling Gao, Qian Xu, Gao‐Qian Wang, Liang-Yan Xiao, Lu Dong, Wei Fang Tang, Jian‐Ming Lv, Guo‐Dong Chen, Ying Wang, Zhinan Yin, Ligong Lu, Dan Hu, Hao Gao

Journal of Natural Products

DOI

2024

Biosynthesis of fungal terpenoids

Pan Luo, Jia-Hua Huang, Jian‐Ming Lv, Gao‐Qian Wang, Dan Hu, Hao Gao

Natural Product Reports

DOI

2024

Mechanistic characterisation of a fungal fusicoccane-type diterpene synthase involved in the biosynthesis of talaro-7,13-diene

Fu-Long Lin, Kizerbo A. Taizoumbe, Yixuan Wang, Jia-Hua Huang, Gao‐Qian Wang, Guo‐Dong Chen, Jian‐Ming Lv, Dan Hu, Hao Gao, Jeroen S. Dickschat

Organic & Biomolecular Chemistry

DOI

2023

Isolation of new compounds related to xyloketals biosynthesis implies an alternative pathway for furan-fused-chromene formation

Jia-Hua Huang, Jian‐Ming Lv, Yan-Feng Xie, Huan Zhao, Liang-Yan Xiao, Ping Dai, Sheng-Ying Qin, Dan Hu, Hao Gao, Xin‐Sheng Yao

Organic & Biomolecular Chemistry

DOI

2023

Identification of new bisabosqual-type meroterpenoids reveals non-enzymatic conversion of bisabosquals into seco -bisabosquals

Meng-Xi Tong, Yong-Xia Duan, Yingdong Zhang, Wan-Yi Ye, Sheng-Ying Qin, Xingzhong Liu, Guodong Chen, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2022

真菌沉默基因簇激活策略研究进展

吕建明，曹志秦，黄嘉华，陈国栋，胡丹，高昊

《药学进展》

2022

Biosynthesis of fusicoccane-type diterpenoids featuring a 5–8–5 tricyclic carbon skeleton

Jing-Yuan Liu, Fu-Long Lin, Jian‐Ming Lv, Dan Hu, Hao Gao

Tetrahedron Letters

DOI

2022

Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues via combinatorial biosynthesis

Xinyu Li, Jian‐Ming Lv, Zhiqin Cao, Gao‐Qian Wang, Fu-Long Lin, Guo‐Dong Chen, Sheng-Ying Qin, Dan Hu, Hao Gao, Xin‐Sheng Yao

Organic & Biomolecular Chemistry

DOI

2022

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

Jia-Hua Huang, Jian‐Ming Lv, Liang-Yan Xiao, Qian Xu, Fu-Long Lin, Gao‐Qian Wang, Guodong Chen, Sheng-Ying Qin, Dan Hu, Hao Gao

Beilstein Journal of Organic Chemistry

DOI

2022

Discovery and characterization of a novel sub-group of UbiA-type terpene cyclases with a distinct motif I

Pan Luo, Jian‐Ming Lv, Yan-Feng Xie, Liang-Yan Xiao, Sheng-Ying Qin, Guo‐Dong Chen, Xiaozhou Luo, Dan Hu, Hao Gao

Organic Chemistry Frontiers

DOI

2021

天然产物中炔基的生物合成机制研究及其应用

吕建明，赵欢，胡丹，高昊

《合成生物学》

2020

Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

Xiaojun Song, Jian‐Ming Lv, Zhiqin Cao, Huiyun Huang, Guo‐Dong Chen, Takayoshi Awakawa, Dan Hu, Hao Gao, Ikuro Abe, Xin‐Sheng Yao

Acta Pharmaceutica Sinica B

DOI

2020

Biosynthesis of Biscognienyne B Involving a Cytochrome P450‐Dependent Alkynylation

Jian‐Ming Lv, Yaohui Gao, Huan Zhao, Takayoshi Awakawa, Ling Liu, Guo‐Dong Chen, Xin‐Sheng Yao, Dan Hu, Ikuro Abe, Hao Gao

Angewandte Chemie

DOI

2020

Biosynthesis of alkyne-containing natural products

Xinyang Li, Jian‐Ming Lv, Dan Hu, Ikuro Abe

RSC Chemical Biology

DOI

2020

Mechanistic Characterization of the Fusicoccane-type Diterpene Synthase for Myrothec-15(17)-en-7-ol

Fu-Long Lin, Lukas Lauterbach, Jian Zou, Yongheng Wang, Jian‐Ming Lv, Guo‐Dong Chen, Dan Hu, Hao Gao, Xin‐Sheng Yao, Jeroen S. Dickschat

ACS Catalysis

DOI

2019

Biosynthetic Study of Cephalosporin P1 Reveals a Multifunctional P450 Enzyme and a Site-Selective Acetyltransferase

Zhi-Qin Cao, Jian‐Ming Lv, Qiu Liu, Sheng-Ying Qin, Guo‐Dong Chen, Ping Dai, Yue Zhong, Hao Gao, Xin‐Sheng Yao, Dan Hu

ACS Chemical Biology

DOI

2018

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

Zhiqin Cao, Shaoyang Li, Jian‐Ming Lv, Hao Gao, Guo‐Dong Chen, Takayoshi Awakawa, Ikuro Abe, Xin‐Sheng Yao, Dan Hu

Acta Pharmaceutica Sinica B

DOI

2018

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Gao‐Qian Wang, Guo‐Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian‐Ming Lv, Chuanxi Wang, Xin‐Sheng Yao, Ikuro Abe, Hao Gao

Nature Communications

DOI

2018

Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A

Jia-Hua Huang, Jian‐Ming Lv, Qiao-Zhen Wang, Jian Zou, Yongjun Lu, Qinglin Wang, Dongni Shao Chen, Xin‐Sheng Yao, Hao Gao, Dan Hu

Organic & Biomolecular Chemistry

DOI

2017

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

Jian‐Ming Lv, Dan Hu, Hao Gao, Tetsuo Kushiro, Takayoshi Awakawa, Guo‐Dong Chen, Chuanxi Wang, Ikuro Abe, Xin‐Sheng Yao

Nature Communications

DOI

吕建明

精选作品

期刊论文

Unraveling stereochemical control mechanisms of neuroactive securinine via isotope-guided spatial transcriptomic strategy

Structural and catalytic mechanisms of two N-hydroxycinnamoyltransferases underlying lycibarbarspermidines biosynthesis in wolfberry

Biosynthesis of Xyloketals: Furanochromene Skeleton Formed via Heterodimerization of Two Orsellinic Acid-Branched Metabolites

Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension

Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Generation of two novel furanosteroids via heterologous expression of demethoxyviridin biosynthetic genes in a wortmannin-producing strain

A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process

Ein funktioneller Wechsel zwischen Asperfumen‐ und Fusicoccadien‐Synthase und Eintritt in die Asperfumen‐Biosynthese durch einen vicinalen Deprotonierungs‐Reprotonierungsprozess

Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

Targeted Discovery of a Natural ortho-Quinone Methide Precursor and Green Generation of Its Oligomers

Identification of three novel P450 enzymes involved in the oxidative modification of a newly discovered fusicoccane diterpene

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage

Absolute Configuration of Oxabornyl Polyenes Prugosenes A1–A3 and Structural Revision of Prugosene A2

Biosynthesis of fungal terpenoids

Mechanistic characterisation of a fungal fusicoccane-type diterpene synthase involved in the biosynthesis of talaro-7,13-diene

Isolation of new compounds related to xyloketals biosynthesis implies an alternative pathway for furan-fused-chromene formation

Identification of new bisabosqual-type meroterpenoids reveals non-enzymatic conversion of bisabosquals into seco -bisabosquals

真菌沉默基因簇激活策略研究进展

Biosynthesis of fusicoccane-type diterpenoids featuring a 5–8–5 tricyclic carbon skeleton

Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues via combinatorial biosynthesis

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

Discovery and characterization of a novel sub-group of UbiA-type terpene cyclases with a distinct motif I

天然产物中炔基的生物合成机制研究及其应用

Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

Biosynthesis of Biscognienyne B Involving a Cytochrome P450‐Dependent Alkynylation

Biosynthesis of alkyne-containing natural products

Mechanistic Characterization of the Fusicoccane-type Diterpene Synthase for Myrothec-15(17)-en-7-ol

Biosynthetic Study of Cephalosporin P1 Reveals a Multifunctional P450 Enzyme and a Site-Selective Acetyltransferase

Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis

研究方向