百晓学者学者目录

蔡华

研究员、硕士生导师，广州医科大学

精选作品

期刊论文

2026

DrosGB: An integrated multi-omics database for comparative genomics and functional annotation of 35 Drosophila species

Qi Zheng, Chuanchang Zhang, Junhui Zhang, Haitian Hao, Xue Ming Wu, Hua Cai, Runxi Shen, Quan Zheng, Xiangrui Cai, Mo Liu

hLife

2026

From Drosophila to mammals: The evolutionarily conserved homeodomain protein Engrailed affects the antitumor innate immune response

Jieqing Huang, X.Y. Lan, Xiaoming Huang, Yuntong Yuan, Mo Liu, Jiyong Liu, J S Chen, Zhenhui Ye, Ziming Wei, Yuqiang Chen, Zihao Deng, Yuhong Zhang, Yanzhen He, Xiaojing Zhou, Zhenming Cao, Mengyu Jiu, Renjie Jiao, Hua Cai, Jules A. Hoffmann, DJ Chen

Proceedings of the National Academy of Sciences

DOI

2026

FADD is recruited to activated STING oligomers to initiate caspase-mediated NF-κB activation in Drosophila melanogaster

Kasper Grønbjerg Winther, Juliette Schneider, Gabrielle Haas, Anna Hvarregaard Christensen, Shreya Goyal, Weisheng Luo, Ziming Wei, Jiyong Liu, Katarzyna Kjøge, Jan J. Enghild, Carine Meignin, Neal S. Silverman, Hua Cai, Jean‐Luc Imler, Rune Hartmann

The EMBO Journal

DOI

2026

The IKK complex and TBK1/IKKε are recruited to STING through distinct mechanisms to activate NF-κB signaling

Anna Hvarregaard Christensen, Aneta Jurkiewicz, Cathrine Silberbauer Jensen, Katarzyna Kjøge, Weisheng Luo, Wenhao He, Yuqiang Chen, Jiyong Liu, Louise Dalskov, Andreas Bondrup Bagger, Kasper Grønbjerg Winther, Katrine Gårn Gulstad, Anna Lorentzen, Gabrielle Haas, Julia M. Kamper, Che Stafford, Mads Gyrd‐Hansen, Jan J. Enghild, Veit Hornung, Hua Cai, Jean‐Luc Imler, Hans Henrik Gad, Rune Hartmann

Science Immunology

DOI

2025

Exploring innate immunity through the lens of fruit fly models

Di Chen, Hua Cai, Chuanxian Wei, Renjie Jiao, Jean‐Luc Imler, Dominique Ferrandon, Jules A. Hoffmann

hLife

DOI

2024

cGAS-like receptors drive a systemic STING-dependent host response in Drosophila

Xianlong Ai, Huimin Deng, Xiaoyan Li, Ziming Wei, Yuqiang Chen, Ting Yin, Junhui Zhang, Jingxian Huang, Haoming Li, Xiaoqing Lin, Long Tan, Di Chen, Xiaohan Zhang, Xiuqing Zhang, Carine Meignin, Jean‐Luc Imler, Hua Cai

Cell Reports

DOI

2024

Investigating the Evolution of Drosophila STING-Dependent Antiviral Innate Immunity by Multispecies Comparison of 2′3′-cGAMP Responses

Léna Hédelin, Antonin Thiébaut, Jingxian Huang, Xiaoyan Li, Aurélie Lemoine, Gabrielle Haas, Carine Meignin, Hua Cai, Robert Michael Waterhouse, Nelson Eduardo Martins, Jean‐Luc Imler

Molecular Biology and Evolution

DOI

2024

Evolutionary immunology to explore original antiviral strategies

Jean‐Luc Imler, Hua Cai, Carine Meignin, Nelson Eduardo Martins

Philosophical Transactions of the Royal Society B Biological Sciences

DOI

2023

The virus-induced cyclic dinucleotide 2′3′-c-di-GMP mediates STING-dependent antiviral immunity in Drosophila

Hua Cai, Lihua Li, Kailey M. Slavik, Jingxian Huang, Ting Yin, Xianlong Ai, Léna Hédelin, Gabrielle Haas, Zhangmin Xiang, Yunyun Yang, Xiaoyan Li, Yuqiang Chen, Ziming Wei, Huimin Deng, Di Chen, Renjie Jiao, Nelson Eduardo Martins, Carine Meignin, Philip J. Kranzusch, Jean‐Luc Imler

Immunity

DOI

2022

cGAS-like receptor-mediated immunity: the insect perspective

Hua Cai, Carine Meignin, Jean‐Luc Imler

Current Opinion in Immunology

DOI

2021

cGAS-like receptors sense RNA and control 3′2′-cGAMP signalling in Drosophila

Kailey M. Slavik, Benjamin R. Morehouse, Adelyn E. Ragucci, Wen Zhou, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Heike Bähre, Martin F. König, Roland Seifert, Amy S.Y. Lee, Hua Cai, Jean‐Luc Imler, Philip J. Kranzusch

Nature

DOI

2021

Two cGAS-like receptors induce antiviral immunity in Drosophila

Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Wissendorf Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean‐Luc Imler, Rune Hartmann

Nature

DOI

2021

cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette

Hua Cai, Jean‐Luc Imler

Faculty Reviews

DOI

2020

2′3′-cGAMP triggers a STING- and NF-κB–dependent broad antiviral response in Drosophila

Hua Cai, Andreas Holleufer, Bine Wissendorf Simonsen, Juliette Schneider, Aurélie Lemoine, Hans Henrik Gad, Jingxian Huang, Jieqing Huang, Di Chen, Tao Peng, João Trindade Marques, Rune Hartmann, Nelson Eduardo Martins, Jean‐Luc Imler

Science Signaling

DOI

2018

The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

Akira Goto, Kiyoshi Okado, Nelson Eduardo Martins, Hua Cai, Vincent Barbier, Olivier Lamiable, L. Troxler, Estelle Santiago, Lauriane Kühn, Donggi Paik, Neal S. Silverman, Andreas Holleufer, Rune Hartmann, Jiyong Liu, Tao Peng, Jules A. Hoffmann, Carine Meignin, Laurent Daeffler, Jean‐Luc Imler

Immunity

DOI

预印本

2026

Cyclic dinucleotides induce chromatin remodeling associated with long-lasting antiviral protection in flies and bees

Hua Cai, Yuqiang Chen, Ziming Wei, Xianlong Ai, Cardamone Francesco, Jingxian Zhou, Antonin Thiébaut, Junhui Zhang, Jingxian Huang, Yin Ting, He Wenhao, Huimin Deng, Huang Zhanxin, Lin Xiaoqing, Tan Long, Xiaohan Zhang, Liu Jiyong, Mo Liu, DJ Chen, Renjie Jiao, Robert Michael Waterhouse, Carine Meignin, Nicola Iovino, João Trindade Marques, Jean‐Luc Imler

Research Square

DOI

研究方向

利用果蝇和哺乳动物为模型研究病毒组分与模式识别受体结合诱导的抗病毒天然免疫及其进化

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