百晓学者学者目录

洪亮

博士生导师、教授、研究员，武汉大学

精选作品

期刊论文

2026

清末民初“海派”律师的萌芽与兴起（下）

洪亮

《中国律师》

2026

抗战期间燕卜荪在中国的诗歌创作与教学活动

洪亮

《抗战文化研究》

2026

清末民初“海派”律师的萌芽与兴起（上）

洪亮

《中国律师》

2026

Self-evolving AI agents for protein discovery and directed evolution

Yang Tan, Lingrong Zhang, Ming-Chen Li, Yuan-Xi Yu, Bozitao Zhong, Bingxin Zhou, Nan-Qing Dong, Liang Hong

arXiv.org

DOI

2026

Deep learning-guided design of hydrolases for crystalline PET depolymerization

Banghao Wu, Ming-Chen Li, Jia-Xing Zhang, Jingchuan Li, Xu-Ling Wang, Bozitao Zhong, Jia-Wei Liu, Yunjie Liu, Bowen Wang, Yang Tan, Wei Qi, P. Tan, Wei-Shu Zhao, Lirong Zheng, Liang Hong

bioRxiv

DOI

2026

Retrieval-Augmented Multimodal Learning for Enzyme-Substrate Interaction Prediction Under Low-Homology Shift

Chen Liu, Bingxin Zhou, Xinyuan Wang, Ming Li, Gui-Sheng Fan, Liang Hong

arXiv.org

DOI

2026

Artificial intelligence-guided engineering of a thermostable cellulase cocktail enables efficient biomass hydrolysis at elevated temperatures.

Runye Huang, Jin Huang, P. Tan, Liang Hong

Bioresource Technology

DOI

2025

VenusFactory: An Integrated System for Protein Engineering with Data Retrieval and Language Model Fine-Tuning

Yang Tan, Chen Liu, Jing-Yuan Gao, Banghao Wu, Ming-Chen Li, Ruilin Wang, Lingrong Zhang, Hui-Qun Yu, Gui-Sheng Fan, Liang Hong, Bingxin Zhou

Annual Meeting of the Association for Computational Linguistics

DOI

2025

VenusX: Unlocking Fine-Grained Functional Understanding of Proteins

Yang Tan, Wenrui Gou, Bozitao Zhong, Liang Hong, Hui-Qun Yu, Bingxin Zhou

arXiv.org

DOI

2025

Semantical and geometrical protein encoding toward enhanced bioactivity and thermostability

Yang Tan, Bingxin Zhou, Lirong Zheng, Gui-Sheng Fan, Liang Hong

bioRxiv

DOI

2025

VenusMutHub: A systematic evaluation of protein mutation effect predictors on small-scale experimental data

Liang Zhang, Hua Pang, Chenghao Zhang, Song Li, Yang Tan, Fan Jiang, Ming-Chen Li, Yuan-Xi Yu, Zi-Yi Zhou, Banghao Wu, Bingxin Zhou, Hao Liu, P. Tan, Liang Hong

Acta Pharmaceutica Sinica B

DOI

2025

Fast and Interpretable Protein Substructure Alignment via Optimal Transport

Zhiyu Wang, Bingxin Zhou, Jing Wang, Yang Tan, Wei-Shu Zhao, Pietro Liò, Liang Hong

arXiv.org

DOI

2025

From high-throughput evaluation to wet-lab studies: advancing mutation effect prediction with a retrieval-enhanced model

Yang Tan, Ruilin Wang, Banghao Wu, Liang Hong, Bingxin Zhou

Bioinform.

DOI

2025

Harnessing protein language model for structure-based discovery of highly efficient and robust PET hydrolases

Banghao Wu, Bozitao Zhong, Lirong Zheng, Runye Huang, Shifeng Jiang, Ming-Chen Li, Liang Hong, P. Tan

Nature Communications

DOI

2025

Response to "Comment on 'A random batch Ewald method for charged particles in the isothermal-isobaric ensemble'" [J. Chem. Phys. 162, 177101 (2025)].

Jiuyang Liang, P. Tan, Liang Hong, Shi Jin, Zhe Xu, Lei Li

Journal of Chemical Physics

DOI

2024

2010-2021年中国现代文学博士论文选题分析

洪亮

《大文学评论》

2024

Unlearning Virus Knowledge Toward Safe and Responsible Mutation Effect Predictions

Ming-Chen Li, Bingxin Zhou, Yang Tan, Liang Hong

bioRxiv

DOI

2024

Protein Representation Learning with Sequence Information Embedding: Does it Always Lead to a Better Performance?

Yang Tan, Lirong Zheng, Bozitao Zhong, Liang Hong, Bingxin Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2024

Decoupling of the onset of anharmonicity between a protein and its surface water around 200 K

Lirong Zheng, Bingxin Zhou, Banghao Wu, Yang Tan, Juan Huang, Madhusudan Tyagi, Victoria García Sakai, Takeshi Yamada, H. O'Neill, Qiu Zhang, Liang Hong

bioRxiv

DOI

2024

Protein engineering in the deep learning era

Bingxin Zhou, Yang Tan, Yu-Tong Hu, Lirong Zheng, Bozitao Zhong, Liang Hong

mLife

DOI

2024

Simple, Efficient and Scalable Structure-aware Adapter Boosts Protein Language Models

Yang Tan, Ming-Chen Li, Bingxin Zhou, Bozitao Zhong, Lirong Zheng, P. Tan, Zi-Yi Zhou, Hui-Qun Yu, Gui-Sheng Fan, Liang Hong

Journal of Chemical Information and Modeling

DOI

2024

PROTSOLM: Protein Solubility Prediction with Multi-modal Features

Yang Tan, Jiandi Zheng, Liang Hong, Bingxin Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2024

Enhancing efficiency of protein language models with minimal wet-lab data through few-shot learning

Zi-Yi Zhou, Liang Zhang, Yuan-Xi Yu, Banghao Wu, Ming-Chen Li, Liang Hong, P. Tan

Nature Communications

DOI

2024

Secondary Structure-Guided Novel Protein Sequence Generation with Latent Graph Diffusion

Yu-Tong Hu, Yang Tan, Andi Han, Lirong Zheng, Liang Hong, Bingxin Zhou

IEEE International Conference on Bioinformatics and Biomedicine

DOI

2024

Retrieval-Enhanced Mutation Mastery: Augmenting Zero-Shot Prediction of Protein Language Model

Yang Tan, Ruilin Wang, Banghao Wu, Liang Hong, Bingxin Zhou

arXiv.org

DOI

2024

ProSST: Protein Language Modeling with Quantized Structure and Disentangled Attention

Ming-Chen Li, P. Tan, Xin-Zhu Ma, Bozitao Zhong, Hui-Qun Yu, Zi-Yi Zhou, Wan-Li Ouyang, Bingxin Zhou, Liang Hong, Yang Tan

bioRxiv

DOI

2024

Immunogenicity Prediction with Dual Attention Enables Vaccine Target Selection

Song Li, Yang Tan, Song Ke, Liang Hong, Bingxin Zhou

International Conference on Learning Representations

DOI

2024

PETA: evaluating the impact of protein transfer learning with sub-word tokenization on downstream applications

Yang Tan, Ming-Chen Li, Ziyi Zhou, P. Tan, Hui-Qun Yu, Gui-Sheng Fan, Liang Hong

Journal of Cheminformatics

DOI

2024

A general temperature-guided language model to design proteins of enhanced stability and activity

Fan Jiang, Ming-Chen Li, Jiajun Dong, Yuan-Xi Yu, Xinyu Sun, Banghao Wu, Jin Huang, Liqi Kang, Yufeng Pei, Liang Zhang, Shaojie Wang, Wen-Xue Xu, Jingyao Xin, Wang-Li Ouyang, Gui-Sheng Fan, Lirong Zheng, Yang Tan, Zhi-Qiang Hu, Yi Xiong, Yan Feng, Guang-Yu Yang, Qian Liu, Jie Song, Jia Liu, Liang Hong, P. Tan

Science Advances

DOI

2024

Direct Observation of the Mutual Coupling Effect in the Protein-Water-Glycerol Mixture by Combining Neutron Scattering and Selective Deuteration.

Yong-Feng Ye, Lirong Zheng, Liang Hong, Victoria García Sakai, N. D. de Souza, Da-Hong Teng, Bin Wu, Yi-Chao Xu, Jin-Zhen Cai, Zhuo Liu

Journal of Physical Chemistry B

DOI

2024

Dynamic entity formed by protein and its hydration water

Yong-Feng Ye, Xiaoxia Chen, Juan Huang, Lirong Zheng, Qingxue Tang, Liuliu Long, Takeshi Yamada, Madhusudan Tyagi, Victoria García Sakai, H. O'Neill, Qiu Zhang, N. D. de Souza, Xiang Xiao, Wei-Shu Zhao, Liang Hong, Zhuo Liu

Physical Review Research

DOI

2024

Erratum: "A random batch Ewald method for charged particles in the isothermal-isobaric ensemble" [J. Chem. Phys. 157, 144102 (2022)].

Jiuyang Liang, P. Tan, Liang Hong, Shi Jin, Zhen-Li Xu, Lei Li

Journal of Chemical Physics

DOI

2023

2011—2021年中国现代文学史著作概评

洪亮

《中国现代文学研究丛刊》，No. 7

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2023

Mn 2 +-Induced Structural Flexibility Enhances the Entire Catalytic 1 Cycle and the Cleavage of Mismatches in Prokaryotic Argonaute 2 Proteins 3

Lirong Zheng, Bing Zan, Yu Yang, Bingxin Zhou, Nuolan Li, Banghao Wu, Fan Jiang, Yan Feng, Qian Liu, Liang Hong

2023

Protein Engineering with Lightweight Graph Denoising Neural Networks

Bingxin Zhou, Lirong Zheng, Banghao Wu, Yang Tan, Outongyi Lv, Kai Yi, Gui-Sheng Fan, Liang Hong

bioRxiv

DOI

2023

Creatinase: Using Increased Entropy to Improve the Activity and Thermostability.

Fan Jiang, Jiahao Bian, H. Liu, Song-bo Li, Xue Bai, Lirong Zheng, Shan Jin, Zhuo Liu, Guang-Yu Yang, Liang Hong

Journal of Physical Chemistry B

DOI

2023

LS-MolGen: Ligand-and-Structure Dual-Driven Deep Reinforcement Learning for Target-Specific Molecular Generation Improves Binding Affinity and Novelty

Song-bo Li, Chao Hu, Song Ke, Chen-Xing Yang, Jun Chen, Y. Xiong, H. Liu, Liang Hong

Journal of Chemical Information and Modeling

DOI

2023

ScaffoldGVAE: scaffold generation and hopping of drug molecules via a variational autoencoder based on multi-view graph neural networks

Chao Hu, Song-bo Li, Chen-Xing Yang, Jun Chen, Yi Xiong, Gui-Sheng Fan, Hao Liu, Liang Hong

Journal of Cheminformatics

DOI

2022

时代夹缝中的另类“经典”——重读《芙瑞达》

洪亮

《广播电视大学学报(哲学社会科学版)》

2022

"同病异名"的肺结核与痨病——兼论中国现代文学中"身体"的多义性

洪亮

《东岳论丛》，Vol. 43, No. 6

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2022

A Ligand-and-structure Dual-driven Deep Learning Method for the Discovery of Highly Potent GnRH1R Antagonist to treat Uterine Diseases

Song-bo Li, Song Ke, Chen-Xing Yang, Jun Chen, Y. Xiong, Lirong Zheng, Hao Liu, Liang Hong

arXiv.org

DOI

2022

Universal dynamical onset in water at distinct material interfaces

Lirong Zheng, Zhuo Liu, Qiang Zhang, Song-bo Li, Juan Huang, Lei Zhang, Bing Zan, M. Tyagi, He Cheng, Tai-Sen Zuo, V. G. Sakai, Takeshi Yamada, Chen-Xing Yang, P. Tan, Fan Jiang, Hao Chen, W. Zhuang, Liang Hong

Chemical Science

DOI

2022

Enhancement of thermal stability of proteinase K by biocompatible cholinium-based ionic liquids.

Rui Li, Zhuo Liu, Fan Jiang, Yang Zhao, Guangyu Yang, Liang Hong

Physical Chemistry, Chemical Physics - PCCP

DOI

2022

Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria

Wei-Shu Zhao, Bozitao Zhong, Lirong Zheng, P. Tan, Yin-Zhao Wang, Hao Leng, Nicolas Raphael de Souza, Zhuo Liu, Liang Hong, Xiang Xiao

Nature Communications

DOI

2022

Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity

Lirong Zheng, Hui Lu, Bing Zan, Song-bo Li, Hao Liu, Zhuo Liu, Juan Huang, Yongjia Liu, Fan Jiang, Qian Liu, Yan Feng, Liang Hong

Nucleic Acids Research

DOI

2022

SAM-DTA: a sequence-agnostic model for drug-target binding affinity prediction

Zhi-Qiang Hu, Wenfeng Liu, Chenbin Zhang, Jiawen Huang, Shao-Ting Zhang, Huiqun Yu, Y. Xiong, H. Liu, Song Ke, Liang Hong

Briefings Bioinform.

DOI

2022

Conduction Mechanism in Graphene Oxide Membranes with Varied Water Content: From Proton Hopping Dominant to Ion Diffusion Dominant.

Lei Zhang, Zhuo Liu, Chen-Xing Yang, Victoria García Sakai, M. Tyagi, Liang Hong

ACS Nano

DOI

2021

The ω3 scaling of the vibrational density of states in quasi-2D nanoconfined solids

Yuan-Hai Yu, Chen-Xing Yang, Matteo Baggioli, A. Phillips, A. Zaccone, Lei Zhang, R. Kajimoto, M. Nakamura, De-Hong Yu, Liang Hong

Nature Communications

DOI

2021

Solid-Like Nano-Anion Cluster Constructs a Free Lithium-Ion-Conducting Superfluid Framework in a Water-in-Salt Electrolyte

P. Tan, Jin-Ming Yue, Yuan-Xi Yu, Bing-Hang Liu, Tao Liu, Lirong Zheng, Lunhua He, Xiao-Hua Zhang, L. Suo, Liang Hong

DOI

2020

论萧红《生死场》中两种“意义”的交锋

洪亮

《广播电视大学学报(哲学社会科学版)》

DOI

2020

Heterogeneity of Water Molecules on the Free Surface of Thin Reduced Graphene Oxide Sheets

Zhuo Liu, Chen-Xing Yang, Lei Zhang, Yuan-Xi Yu, M. Yu, Victoria García Sakai, M. Tyagi, Takeshi Yamada, Lunhua He, Xiao-Hua Zhang, Liang Hong

DOI

2019

《荆生》《妖梦》的评价与现代文学研究的“专业立场”

洪亮

《内蒙古开放大学学报》

DOI

2019

“抗战建国”与官方民族主义的两面性——1940年代的三民主义文学批判之三

洪亮

《抗战文化研究》

2017

民生主义的“陷阱”——二十世纪四十年代的三民主义文学批判之二

洪亮

《宜宾学院学报》

2017

《民族主义文艺运动宣言》发表情况及作者问题考

洪亮

《现代中国文化与文学》

2016

挣扎在“新”与“旧”之间——1940年代的三民主义文学批判之一

洪亮

《山东师范大学学报(社会科学版)》，No. 6

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2016

中国现代文学中的脏话

洪亮

《广播电视大学学报(哲学社会科学版)》

2015

“民间伦理”与现代文学的雅俗互动及其分野——以三仙姑、曹七巧形象为中心

洪亮

《中国现代文学研究丛刊》，No. 7

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2015

论东北沦陷区的“抗日文学”

洪亮

《西南民族大学学报(人文社会科学版)》，Vol. 36, No. 10

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2014

“民国视野”与现代文学的“研究范式”

洪亮

《中国现代文学研究丛刊》，No. 7

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2013

1984--2012年中国现代文学博士论文选题分析

洪亮

《中国现代文学研究丛刊》，No. 7

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2013

1984-2012年中国现代文学博士论文题名一览表

洪亮，洪亮(辑录)

《中国现代文学研究丛刊》，No. 7

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2012

中国现代文学史编纂的历史与现状

洪亮

《中国现代文学研究丛刊》，No. 7

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2007

“短命”的中国现代派小说

洪亮

《语文学刊(教育版)》

三民主義文化/文學的宿命與救贖

洪亮

《花木蘭文化出版社》

Lightweight Equivariant Graph Representation Learning for Protein Engineering

Bingxin Zhou, Outongyi Lv, Kai Yi, Xinye Xiong, P. Tan, Liang Hong, Yu-Guang Wang

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