王书元｜哈尔滨医科大学｜学者主页

2023

Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human

Hui Liu, Yingying Ma, Jia-Xin Yu, Xiang Chen, Shuyuan Wang, Yijie Jia, Na Ding, Xiao-Yan Jin, Yunpeng Zhang, Juan Xu, Xia Li

Molecular Therapy: Nucleic Acids

DOI

2020

ncRI: a manually curated database for experimentally validated non-coding RNAs in inflammation

Shuyuan Wang, Shunheng Zhou, Haizhou Liu, Qianqian Meng, Xueyan Ma, Hui Liu, Li-Hong Wang, Wei Jiang

BMC Genomics

DOI

2020

Context-Specific Coordinately Regulatory Network Prioritize Breast Cancer Genetic Risk Factors

Shuyuan Wang, Wen-Can Wang, Wei-Da Wang, Peng Xia, Lei Yu, Ye Lu, Xiaowen Chen, Chaohan Xu, Hui Liu

Frontiers in Genetics

DOI

2020

Systematical identification of cell-specificity of CTCF-gene binding based on epigenetic modifications

Jie Wu, Li Zhang, Qian Song, Lei Yu, Shuyuan Wang, Bo Zhang, Wei-Da Wang, Peng Xia, Xiaowen Chen, Yun Xiao, Chaohan Xu

Briefings Bioinform.

DOI

2020

Efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients.

Hong-Mei Zhang, Chen-Chen Chen, Shuyuan Wang, Xiaoxia Li, Ting-Ting Fan

Journal of B.U.ON. : official journal of the Balkan Union of Oncology

2019

Long non‑coding RNA TP73 antisense RNA 1 facilitates the proliferation and migration of cervical cancer cells via regulating microRNA‑607/cyclin D2.

Hong-Mei Zhang, Bingjian Xue, Shuyuan Wang, Xiaoxia Li, Ting-Ting Fan

Molecular Medicine Reports

DOI

2019

Systematical Identification of Breast Cancer-Related Circular RNA Modules for Deciphering circRNA Functions Based on the Non-Negative Matrix Factorization Algorithm

Shuyuan Wang, Peng Xia, Li Zhang, Lei Yu, Hui Liu, Qianqian Meng, Si-Yao Liu, Jie Li, Qian Song, Jie Wu, Wei-Da Wang, Lei Yang, Yun Xiao, Chaohan Xu

International Journal of Molecular Sciences

DOI

2019

A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome

Hui Liu, Tiantongfei Jiang, Shuyuan Wang, Xiang Chen, Xiao-Yan Jin, Qi Wang, Xinhui Li, Jiaqi Yin, Ting-Ting Shao, Yong-Sheng Li, Juan Xu, Qiong Wu

Frontiers in Bioengineering and Biotechnology

DOI

2019

D-lnc: a comprehensive database and analytical platform to dissect the modification of drugs on lncRNA expression

Wei Jiang, Yinwei Qu, Qian Yang, Xueyan Ma, Qianqian Meng, Juan Xu, Xinyi Liu, Shuyuan Wang

RNA Biology

DOI

2019

Drug Resistance-Related Competing Interactions of lncRNA and mRNA across 19 Cancer Types

Haizhou Liu, Shuyuan Wang, Shunheng Zhou, Qianqian Meng, Xueyan Ma, Xiao-Feng Song, Li-Hong Wang, Wei Jiang

Molecular Therapy: Nucleic Acids

DOI

2019

Dissecting the m6A methylation affection on afatinib resistance in non-small cell lung cancer

Qianqian Meng, Shuyuan Wang, Shunheng Zhou, Haizhou Liu, Xueyan Ma, Xu Zhou, Hui Liu, Chaoliang Xu, Wei Jiang

The Pharmacogenomics Journal

DOI

2019

Single-cell RNA-seq data reveals TNBC tumor heterogeneity through characterizing subclone compositions and proportions

Wei-Da Wang, Jinyuan Xu, Shuyuan Wang, Peng Xia, Li Zhang, Lei Yu, Jie Wu, Qian Song, Bo Zhang, Chaohan Xu, Yun Xiao

bioRxiv

DOI

2018

Systematical analysis of lncRNA–mRNA competing endogenous RNA network in breast cancer subtypes

Shunheng Zhou, Li-Hong Wang, Qian Yang, Haizhou Liu, Qianqian Meng, Leiming Jiang, Shuyuan Wang, Wei Jiang

Breast Cancer Research and Treatment

DOI

2018

Accurate prediction and elucidation of drug resistance based on the robust and reproducible chemoresponse communities

Enyu Dai, Jing Wang, Feng Yang, Xu Zhou, Qian Song, Shuyuan Wang, Xuexin Yu, Dianming Liu, Qian Yang, Hong Dai, Wei Jiang, Hong Ling

International Journal of Cancer

DOI

2018

Prediction of Non-coding RNAs as Drug Targets.

Wei Jiang, Yingli Lv, Shuyuan Wang

Advances in Experimental Medicine and Biology

DOI

2018

Inferring Novel Autophagy Regulators Based on Transcription Factors and Non-Coding RNAs Coordinated Regulatory Network

Shuyuan Wang, Wen-Can Wang, Qianqian Meng, Shunheng Zhou, Haizhou Liu, Xueyan Ma, Xu Zhou, Hui Liu, Xiaowen Chen, Wei Jiang

Cells

DOI

2017

A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells.

Weisha Liu, Shuyuan Wang, Shunheng Zhou, Feng Yang, Wei Jiang, Qing-Yuan Zhang, Li-Hong Wang

Molecular Biosystems

DOI

2017

Pathway enrichment analysis approach based on topological structure and updated annotation of pathway

Qian Yang, Shuyuan Wang, Enyu Dai, Shunheng Zhou, Dianming Liu, Haizhou Liu, Qianqian Meng, Bin Jiang, Wei Jiang

Briefings Bioinform.

DOI

2017

Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p

Tian Luan, Ximei Zhang, Shuyuan Wang, Yan Song, Shunheng Zhou, Jing Lin, Weiwei An, Wei-Guang Yuan, Yue Yang, Huilong Cai, Qing-Yuan Zhang, Li-Hong Wang

OncoTarget

DOI

2016

Large-scale identification of adverse drug reaction-related proteins through a random walk model

Xiaowen Chen, Hongbo Shi, Feng Yang, Lei Yang, Yingli Lv, Shuyuan Wang, Enyu Dai, Dianjun Sun, Wei Jiang

Scientific Reports

DOI

2016

Psmir: a database of potential associations between small molecules and miRNAs

Fanling Meng, Jing Wang, Enyu Dai, Feng Yang, Xiaowen Chen, Shuyuan Wang, Xuexin Yu, Dianming Liu, Wei Jiang

Scientific Reports

DOI

2016

Crosstalk of dynamic functional modules in lung development of rhesus macaques.

Xuexin Yu, Lin Feng, Zujing Han, Bo Wu, Shuyuan Wang, Yun Xiao, Feng Li, Lian-Feng Zhang, B. Cao, Xuebing Di, Dan Lu, Xia Li, Wei Jiang, Kaitai Zhang, Shujun Cheng

Molecular Biosystems

DOI

2016

The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer

Dianming Liu, Xuexin Yu, Shuyuan Wang, Enyu Dai, Leiming Jiang, Jing Wang, Qian Yang, Feng Yang, Shunheng Zhou, Wei Jiang

OncoTarget

DOI

2016

Identification of associations between small molecule drugs and miRNAs based on functional similarity

Jing Wang, Fanling Meng, Enyu Dai, Feng Yang, Shuyuan Wang, Xiaowen Chen, Lei Yang, Yuwen Wang, Wei Jiang

OncoTarget

DOI

2016

Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation

Xinyi Liu, Dong-Fei Feng, Dianming Liu, Shuyuan Wang, Xuexin Yu, Enyu Dai, Jing Wang, Li-Hong Wang, Wei Jiang

PLoS ONE

DOI

2015

Spatiotemporal-specific lncRNAs in the brain, colon, liver and lung of macaque during development.

Feng Li, Yun Xiao, Fei Huang, W. Deng, Hongying Zhao, Xinrui Shi, Shuyuan Wang, Xuexin Yu, Lian-Feng Zhang, Zujing Han, Long-Hai Luo, Qianhua Zhu, Wei Jiang, Shujun Cheng, Xia Li, Kaitai Zhang

Molecular Biosystems

DOI

2015

Human TF and miRNA regulatory network.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease

Yan Zhang, Dianming Liu, Li-Hong Wang, Shuyuan Wang, Xuexin Yu, Enyu Dai, Xinyi Liu, Shanshun Luo, Wei Jiang

Journal of molecular medicine

DOI

2015

A snapshot of the graphical user interface to the database.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Bar plot of the length distribution of the cascades.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Bar plot of the number of cascades in the clusters.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

TMREC: A Database of Transcription Factor and MiRNA Regulatory Cascades in Human Diseases

Shuyuan Wang, Wei Li, Baofeng Lian, Xinyi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

PLoS ONE

DOI

2015

Illustration cascade search result by AHR.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Illustration of clustering of three cascades.

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Illustration cluster search result by AHR .

Shuyuan Wang, Wei Li, Baofeng Lian, Xin-Yi Liu, Yan Zhang, Enyu Dai, Xuexin Yu, Fanling Meng, Wei Jiang, Xia Li

DOI

2015

Identifying novel associations between small molecules and miRNAs based on integrated molecular networks

Yingli Lv, Shuyuan Wang, Fanling Meng, Lei Yang, Zhi-Feng Wang, Jing Wang, Xiaowen Chen, Wei Jiang, Yixue Li, Xia Li

Bioinform.

DOI

2014

Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease

Fanling Meng, Enyu Dai, Xuexin Yu, Yan Zhang, Xiaowen Chen, Xinyi Liu, Shuyuan Wang, Li-Hua Wang, Wei Jiang

Journal of the Royal Society Interface

DOI

2014

EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications

Enyu Dai, Xuexin Yu, Yan Zhang, Fanling Meng, Shuyuan Wang, Xinyi Liu, Dianming Liu, Jing Wang, Xia Li, Wei Jiang

Database J. Biol. Databases Curation

DOI

2014

The pan-cancer analysis of gene expression patterns in the context of inflammation.

Xuexin Yu, Baofeng Lian, Li-Hong Wang, Yan Zhang, Enyu Dai, Fanling Meng, Dianming Liu, Shuyuan Wang, Xinyi Liu, Jing Wang, Xia Li, Wei Jiang

Molecular Biosystems

DOI

2013

SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression

Xinyi Liu, Shuyuan Wang, Fanling Meng, Jizhe Wang, Yan Zhang, Enyu Dai, Xuexin Yu, Xia Li, Wei Jiang

Bioinform.

DOI

2013

Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease

Wei Jiang, Yan Zhang, Fanling Meng, Baofeng Lian, Xiaowen Chen, Xuexin Yu, Enyu Dai, Shuyuan Wang, Xinyi Liu, Xiang Li, Li-Hong Wang, Xia Li

Bioinform.

DOI

2012

Characterizing the Network of Drugs and Their Affected Metabolic Subpathways

Chunquan Li, D. Shang, Yan Wang, Jing Li, Junwei Han, Shuyuan Wang, Qianlan Yao, Ying-Ying Wang, Yunpeng Zhang, Chunlong Zhang, Yanjun Xu, Wei Jiang, Xia Li

PLoS ONE

DOI

2012

Dissection of human MiRNA regulatory influence to subpathway

Xia Li, Wei Jiang, Wei Li, Baofeng Lian, Shuyuan Wang, Mingzhi Liao, Xiaowen Chen, Yanqiu Wang, Yingli Lv, Shiyuan Wang, Lei Yang

Briefings Bioinform.

DOI

2011

Predicting human microRNA precursors based on an optimized feature subset generated by GA-SVM.

Yanqiu Wang, Xiaowen Chen, Wei Jiang, Li Li, Wei Li, Lei Yang, Mingzhi Liao, Baofeng Lian, Yingli Lv, Shiyuan Wang, Shuyuan Wang, Xia Li

Genomics

DOI

精选作品

期刊论文

Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human

ncRI: a manually curated database for experimentally validated non-coding RNAs in inflammation

Context-Specific Coordinately Regulatory Network Prioritize Breast Cancer Genetic Risk Factors

Systematical identification of cell-specificity of CTCF-gene binding based on epigenetic modifications

Efficacy of bevacizumab combined with nedaplatin in the treatment of ovarian cancer and its effects on tumor markers and immunity of patients.

Long non‑coding RNA TP73 antisense RNA 1 facilitates the proliferation and migration of cervical cancer cells via regulating microRNA‑607/cyclin D2.

Systematical Identification of Breast Cancer-Related Circular RNA Modules for Deciphering circRNA Functions Based on the Non-Negative Matrix Factorization Algorithm

A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome

D-lnc: a comprehensive database and analytical platform to dissect the modification of drugs on lncRNA expression

Drug Resistance-Related Competing Interactions of lncRNA and mRNA across 19 Cancer Types

Dissecting the m6A methylation affection on afatinib resistance in non-small cell lung cancer

Single-cell RNA-seq data reveals TNBC tumor heterogeneity through characterizing subclone compositions and proportions

Systematical analysis of lncRNA–mRNA competing endogenous RNA network in breast cancer subtypes

Accurate prediction and elucidation of drug resistance based on the robust and reproducible chemoresponse communities

Prediction of Non-coding RNAs as Drug Targets.

Inferring Novel Autophagy Regulators Based on Transcription Factors and Non-Coding RNAs Coordinated Regulatory Network

A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells.

Pathway enrichment analysis approach based on topological structure and updated annotation of pathway

Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p

Large-scale identification of adverse drug reaction-related proteins through a random walk model

Psmir: a database of potential associations between small molecules and miRNAs

Crosstalk of dynamic functional modules in lung development of rhesus macaques.

The gain and loss of long noncoding RNA associated-competing endogenous RNAs in prostate cancer

Identification of associations between small molecule drugs and miRNAs based on functional similarity

Dissecting the Origin of Breast Cancer Subtype Stem Cell and the Potential Mechanism of Malignant Transformation

Spatiotemporal-specific lncRNAs in the brain, colon, liver and lung of macaque during development.

Human TF and miRNA regulatory network.

Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease

A snapshot of the graphical user interface to the database.

Bar plot of the length distribution of the cascades.

Bar plot of the number of cascades in the clusters.

TMREC: A Database of Transcription Factor and MiRNA Regulatory Cascades in Human Diseases

Illustration cascade search result by AHR.

Illustration of clustering of three cascades.

Illustration cluster search result by AHR .

Identifying novel associations between small molecules and miRNAs based on integrated molecular networks

Constructing and characterizing a bioactive small molecule and microRNA association network for Alzheimer's disease

EpimiR: a database of curated mutual regulation between miRNAs and epigenetic modifications

The pan-cancer analysis of gene expression patterns in the context of inflammation.

SM2miR: a database of the experimentally validated small molecules' effects on microRNA expression

Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease

Characterizing the Network of Drugs and Their Affected Metabolic Subpathways

Dissection of human MiRNA regulatory influence to subpathway

Predicting human microRNA precursors based on an optimized feature subset generated by GA-SVM.

研究方向