徐伟｜重庆医科大学｜学者主页

2026

缺血性心肌病心力衰竭与心房颤动的共同免疫分子特征及CXCL12、CXCR4的潜在作用

王绍娴，徐伟

《中国心脏起搏与心电生理杂志》

2025

组织驻留记忆T细胞在皮肤病复发中的作用

谢娟，肖春梅，韩晓凤，张金叶，徐伟

《免疫学杂志》

DOI

2025

黄精多糖的分离纯化及其免疫调节活性研究

孙芸芸，赵明，秦诗越，郑斯纯，张皓翔，马晓丹，李肖梁，徐伟

《中国免疫学杂志》

2024

SMAD4突变型结直肠癌患者基因突变及肿瘤免疫微环境特征分析

姬清华，徐伟，张虎山，马俊蕊，黄飞，伍龙，郭伟，张汝一，梁正子

《现代免疫学》

2024

芦丁通过抑制TXNIP/NLRP3信号通路减轻液压冲击脑损伤大鼠神经炎症

徐伟，张山，杨德真，唐会昌，冯孝君，李海昌，胡程舟

《免疫学杂志》

2020

白术多糖对小鼠淋巴细胞的免疫调节作用

徐伟，方思佳，关然，张岑容，胡松华

《中国免疫学杂志》

2018

肿瘤来源外泌体的肿瘤免疫抑制机制的研究进展

徐伟，王珊

《检验医学与临床》

2018

Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

Gang Chen, Alexander C. Huang, Wei Zhang, Gao Zhang, Min Wu, Wei Xu, Zili Yu, Jie-Gang Yang, Bei-Ke Wang, Honghong Sun, Hou-Fu Xia, Qi-Wen Man, Wen-Qun Zhong, Leonardo F. Antelo, Bin Wu, X. Xiong, Xiao-Ming Liu, Lei Guan, Ting Li, Shu-Jing Liu, Rui-Feng Yang, You-Tao Lu, Liyun Dong, S. McGettigan, R. Somasundaram, R. Radhakrishnan, G. Mills, Yi-Ling Lu, Junhyong Kim, You-Hai H. Chen, Haidong Dong, Yi-Fang Zhao, G. Karakousis, T. Gangadhar, L. Schuchter, M. Herlyn, E. Wherry, Xiao-Wei Xu, Wei Guo

Nature

DOI

2018

Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

Ileabett M. Echevarría-Vargas, P. Reyes-Uribe, Adam N. Guterres, Xiang-Fan Yin, A. Kossenkov, Qin Liu, Gao Zhang, C. Krepler, Chaoran Cheng, Zhi Wei, R. Somasundaram, G. Karakousis, Wei Xu, J. Morrissette, Yi-Ling Lu, G. Mills, R. Sullivan, Ben-Chun Miao, Dennie T. Frederick, G. Boland, K. Flaherty, A. Weeraratna, M. Herlyn, R. Amaravadi, L. Schuchter, C. Burd, A. Aplin, Xiao-Wei Xu, J. Villanueva

EMBO Molecular Medicine

DOI

2018

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

Gao Zhang, Lawrence Wu, I. Mender, Michal Barzily-Rokni, Marc R. Hammond, Omotayo Ope, Chaoran Cheng, Themistoklis Vasilopoulos, S. Randell, Norah Sadek, Aurelie Beroard, M. Xiao, Tian Tian, Jiufeng Tan, U. Saeed, Eric Sugarman, C. Krepler, Patricia A. Brafford, Katrin Sproesser, Sengottuvelan Murugan, R. Somasundaram, Bradley Garman, B. Wubbenhorst, J. Woo, Xiang-Fan Yin, Qin Liu, Dennie T. Frederick, Ben-Chun Miao, Wei Xu, G. Karakousis, Xiao-Wei Xu, L. Schuchter, T. Gangadhar, Lawrence N. Kwong, R. Amaravadi, Yi-Ling Lu, G. Boland, Zhi Wei, K. Nathanson, Utz Herbig, G. Mills, K. Flaherty, M. Herlyn, J. Shay

Clinical Cancer Research

DOI

2018

Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

Hezhe Lu, Shu-Jing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wen-Qun Zhong, S. Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence Wu, Jie Zhang, Xiao-Ming Liu, Wei Xu, C. Krepler, Katrin Sproesser, M. Xiao, Ben-Chun Miao, Jianglan Liu, Claire Song, Jephrey Y. Liu, G. Karakousis, L. Schuchter, Yi-Ling Lu, G. Mills, Yusheng Cong, J. Chernoff, Jun Guo, G. Boland, R. Sullivan, Zhi Wei, J. Field, R. Amaravadi, K. Flaherty, M. Herlyn, Xiao-Wei Xu, Wei Guo

Nature

DOI

2017

PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas

Hezhe Lu, Shu-Jing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wen-Qun Zhong, S. Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence Wu, Jie Zhang, Xiao-Ming Liu, Wei Xu, C. Krepler, Katrin Sproesser, M. Xiao, Ben-Chun Miao, Jianglan Liu, Claire Song, Jephrey Y. Liu, G. Karakousis, L. Schuchter, Yi-Ling Lu, G. Mills, Yusheng Cong, J. Chernoff, Jun Guo, G. Boland, R. Sullivan, Zhi Wei, J. Field, R. Amaravadi, K. Flaherty, M. Herlyn, Xiao-Wei Xu, Wei Guo

Nature

DOI

2017

Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies and cell lines

Bradley Garman, Ioannis Anastopoulos, C. Krepler, Patricia A. Brafford, Katrin Sproesser, Yuchao Jiang, B. Wubbenhorst, R. Amaravadi, J. Bennett, M. Beqiri, D. Elder, K. Flaherty, Dennie T. Frederick, T. Gangadhar, M. Guarino, D. Hoon, G. Karakousis, Qin Liu, N. Mitra, N. Petrelli, L. Schuchter, B. Shannan, C. Shields, J. Wargo, Brandon M. Wenz, M. Wilson, M. Xiao, Wei Xu, Xaiowei Xu, Xiang-Fan Yin, N. Zhang, M. Davies, M. Herlyn, K. Nathanson

Cell Reports

DOI

2017

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Fabao Liu, Fengfei Ma, Yuyuan Wang, Ling Hao, H. Zeng, Chenxi Jia, Yi-Dan Wang, Peng Liu, I. Ong, Bao-Bin Li, Guo-Jun Chen, Jiaoyang Jiang, Shaoqin Gong, Ling-Jun Li, Wei Xu

Nature Cell Biology

DOI

2017

Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma

T. Gangadhar, Samantha L. Savitch, S. Yee, Wei Xu, Alexander C. Huang, Shannon Harmon, D. Lieberman, Devon Soucier, Ryan Fan, Taylor A. Black, Jennifer J. D. Morrissette, N. Salathia, Jill Waters, Shi-Le Zhang, J. Toung, P. Van Hummelen, Jian-Bing Fan, Xiao-Wei Xu, R. Amaravadi, L. Schuchter, G. Karakousis, W. Hwang, E. Carpenter

Pigment Cell & Melanoma Research

DOI

2016

Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.

Melody J. Xu, J. Dorsey, R. Amaravadi, G. Karakousis, Charles B. Ii Simone, Xiao-Wei Xu, Wei Xu, E. Carpenter, L. Schuchter, G. Kao

The Oncologist

DOI

2016

Oncogenic BRAF-mediated Melanoma Cell Invasion

Hezhe Lu, Shu-Jing Liu, Gao Zhang, Lawrence N. Kwong, Yueyao Zhu, J. Miller, Yi Hu, Wen-Qun Zhong, Jingwen Zeng, Lawrence Wu, C. Krepler, Katrin Sproesser, M. Xiao, Wei Xu, G. Karakousis, L. Schuchter, J. Field, Paul J. L. Zhang, M. Herlyn, Xiao-Wei Xu, Wei Guo

Cell Reports

DOI

2015

BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth

Tao Wang, M. Xiao, Ying-Bin Ge, C. Krepler, Eric Belser, Alfonso López-Coral, Xiao-Wei Xu, Gao Zhang, Rikka Azuma, Qin Liu, R. Liu, Ling Li, R. Amaravadi, Wei Xu, G. Karakousis, T. Gangadhar, L. Schuchter, Melissa J. Lieu, Sanika Khare, Molly B. Halloran, M. Herlyn, Russel E. Kaufman

Clinical Cancer Research

DOI

2015

Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Meng-Tao Xiao, Hui Yang, Wei Xu, Shenghong Ma, Huaipeng Lin, Hon-Guang Zhu, Li-Xia Liu, Ying Liu, Chen Yang, Yanhui Xu, Shimin Zhao, D. Ye, Yue Xiong, K. Guan

Genes & Development

2015

Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies

C. Krepler, M. Xiao, Katrin Sproesser, Patricia A. Brafford, B. Shannan, M. Beqiri, Qin Liu, Wei Xu, Bradley Garman, K. Nathanson, Xiao-Wei Xu, G. Karakousis, G. Mills, Yi-Ling Lu, Tamer Ahmed, P. Poulikakos, G. Caponigro, M. Boehm, M. Peters, L. Schuchter, A. Weeraratna, M. Herlyn

Clinical Cancer Research

DOI

2015

MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Lu Wang, H. Zeng, Qiang Wang, Zi-Bo Zhao, T. Boyer, X. Bian, Wei Xu

Science Advances

DOI

2014

Abstract 1871: “Capturing the elusive foe”: A novel telomerase promoter-based approach to detect melanoma circulating tumor cells

Melody Ju, G. Kao, Charles B. Ii Simone, David Steinmetz, Xiang-Sheng Xu, L. Aguarin, Wei Xu, E. Bartlett, S. Hahn, J. Dorsey, G. Karakousis

DOI

2012

母亲过敏性哮喘病史对新生儿调节性T细胞的影响

刘晶，张捷，徐伟，许溟宇，任锦，闫冰迪，李成玉，马忠森

《中国免疫学杂志》

2012

Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription

Jia-Cai Wu, Wei Xu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2012

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Meng-Tao Xiao, Hui Yang, Wei Xu, Shenghong Ma, Huaipeng Lin, Hon-Guang Zhu, Li-Xia Liu, Ying Liu, Chen Yang, Yanhui Xu, Shimin Zhao, D. Ye, Yue Xiong, K. Guan

Genes & Development

DOI

2011

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Wei Xu, Hui Yang, Ying Liu, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-Xia Liu, Wenyuan Jiang, Jing Liu, Jinye Zhang, Bin Wang, S. Frye, Yi Zhang, Yan-hui Xu, Qun-Ying Lei, K. Guan, Shimin Zhao, Yue Xiong

Cancer Cell

DOI

2010

TDRD3 is an Effector Molecule for Arginine Methylated Histone Marks

Yan-Zhong Yang, Yue Lu, Alexsandra B. Espejo, Jia-Cai Wu, Wei Xu, Shou-Dan Liang, M. Bedford

Molecules and Cells

DOI

2009

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Shimin Zhao, Yan Lin, Wei Xu, Wen-Qing Jiang, Zhengyu Zha, Pu Wang, Wei Yu, Zhiqiang Li, Lingling Gong, Yingjie Peng, Jianping Ding, Qun-Ying Lei, K. Guan, Yue Xiong

Science

DOI

2007

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1

K. Higashimoto, P. Kuhn, Dhaval Desai, Xiaodong Cheng, Wei Xu

Proceedings of the National Academy of Sciences of the United States of America

DOI

2004

瘦蛋白(Leptin):免疫治疗的新靶点

徐伟，吴少瑜

《国际免疫学杂志》

2003

围术期输血对肿瘤病人T淋巴细胞亚群、NK细胞的影响

王世端，江岩，袁莉，徐伟，董河

《中华微生物学和免疫学杂志》

2002

T细胞免疫缺陷症的类型与发病机理

徐伟，雷林生，吴曙光

《国际免疫学杂志》

2002

T细胞免疫缺陷症的治疗

徐伟，雷林生，吴曙光

《国际免疫学杂志》

1999

哮喘病人B细胞体外产生IgE过程中幼稚性T细胞的影响作用

徐伟，黄瑾，安东善，李淑芳，刘素舫

《中国免疫学杂志》

1998

自然杀伤细胞的细胞毒信号的激活通路与抑制通路

徐伟

《国际免疫学杂志》

精选作品

期刊论文

缺血性心肌病心力衰竭与心房颤动的共同免疫分子特征及CXCL12、CXCR4的潜在作用

组织驻留记忆T细胞在皮肤病复发中的作用

黄精多糖的分离纯化及其免疫调节活性研究

SMAD4突变型结直肠癌患者基因突变及肿瘤免疫微环境特征分析

芦丁通过抑制TXNIP/NLRP3信号通路减轻液压冲击脑损伤大鼠神经炎症

白术多糖对小鼠淋巴细胞的免疫调节作用

肿瘤来源外泌体的肿瘤免疫抑制机制的研究进展

Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response

Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas

PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas

Genetic and genomic characterization of 462 melanoma patient-derived xenografts, tumor biopsies and cell lines

PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis

Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma

Circulating Tumor Cells, DNA, and mRNA: Potential for Clinical Utility in Patients With Melanoma.

Oncogenic BRAF-mediated Melanoma Cell Invasion

BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth

Corrigendum: inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies

MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs

Abstract 1871: “Capturing the elusive foe”: A novel telomerase promoter-based approach to detect melanoma circulating tumor cells

母亲过敏性哮喘病史对新生儿调节性T细胞的影响

Histone H3R17me2a mark recruits human RNA Polymerase-Associated Factor 1 Complex to activate transcription

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

TDRD3 is an Effector Molecule for Arginine Methylated Histone Marks

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α

Phosphorylation-mediated inactivation of coactivator-associated arginine methyltransferase 1

瘦蛋白(Leptin):免疫治疗的新靶点

围术期输血对肿瘤病人T淋巴细胞亚群、NK细胞的影响

T细胞免疫缺陷症的类型与发病机理

T细胞免疫缺陷症的治疗

哮喘病人B细胞体外产生IgE过程中幼稚性T细胞的影响作用

自然杀伤细胞的细胞毒信号的激活通路与抑制通路

会议论文

白花前胡甲素通过NF-κB通路抑制脂多糖诱导的巨噬细胞炎症反应

研究方向