朱焕章｜复旦大学｜学者主页

2026

Preparation, Oral SNEDDS Formulation, and In Vivo Evaluation of the HIV-1 Latency-Reversing Agent EK-16A

Lu Jin, Yu-Qi Zhu, Fan Yang, Ting Chen, Xinyi Yang, Yuan Tang, Yipen Cheng, Dengji Zhang, JN Xun, Jun Liu, Bin Wang, Chunyu Li, Xingyu Wang, Suixiang Li, Xingwen Yu, Zhujian Wang, Yiping Zhang, Qian Zhong, Jianrong Ma, Jing Xue, Huanzhang Zhu

Molecules

DOI

2025

Validation of CCL20-driven CAR-γδ T secreting PD-1 blockade with enhanced trafficking into solid tumor

Dengji Zhang, Yuan Tang, Wei Sun, Yunkun Guan, Yipen Cheng, Yu-Qi Zhu, Xiaying Zhao, Xin-Yi Yang, Huanzhang Zhu

iScience

DOI

2025

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

Xinyi Yang, Yuqi Zhu, Xiaying Zhao, Jingna Xun, Xingyu Wang, Yipeng Cheng, Si Xiong, Xiaocong Yu, Suixiang Li, Dan Wang, Zhiliang Hu, Yinzhong Shen, Shibo Jiang, Hongzhou Lu, Gang Wang, Huanzhang Zhu

Cell Communication and Signaling

DOI

2024

小分子药物提高慢病毒对人γδ T细胞感染效率的研究

梁卉彤，林沁汝，杨辛毅，杨金龙，朱豫琪，梁玥，李敏，成逸鹏，朱焕章

《复旦学报(自然科学版)》

2024

一种高活性γδ T细胞的体外培养方案

林沁汝，梁卉彤，杨辛毅，杨金龙，朱豫琪，梁玥，李敏，成逸鹏，朱焕章

《复旦学报(自然科学版)》

2024

Effective in vivo reactivation of HIV-1 latency reservoir via oral administration of EK-16A-SNEDDS

Jinlong Yang, Chenyi Shi, Yipeng Cheng, Yuqi Zhu, Yuqi Zhu, Xinyi Yang, Yue Liang, Huitong Liang, Qinru Lin, Min Li, Jingna Xun, Jianping Liu, Chunhua Yin, Jianping Qi, Huanzhang Zhu

European Journal of Pharmaceutics and Biopharmaceutics

DOI

2024

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Xinyi Yang, Xu Zheng, Yuqi Zhu, Xiaying Zhao, Jun Liu, Jiangna Xun, Songhua Yuan, Jun Chen, Hanyu Pan, Jin‐Long Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Fei Peng, Daru Lu, Jianqing Xu, Hongzhou Lu, Shibo Jiang, Ping Zhao, Huanzhang Zhu

Signal Transduction and Targeted Therapy

DOI

2023

腺相关病毒介导锌指核酸酶体外切除HIV-1基因组研究

梁智铭，杨辛毅，王亚楠，王菁，沈晓婷，潘浛雨，杨金龙，陆盼盼，赵琳，梁玥，朱焕章

《复旦学报(自然科学版)》

2023

Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression without Global T Cell Activation

Yuqi Zhu, Zhengtao Jiang, Lin Liu, Xinyi Yang, Min Li, Yipeng Cheng, Jianqing Xu, Chunhua Yin, Huanzhang Zhu

International Journal of Molecular Sciences

DOI

2023

Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma

Jing Wang, Yanan Wang, Hanyu Pan, Lin Zhao, Xinyi Yang, Zhiming Liang, Xiaoting Shen, Jing Zhang, Jin‐Long Yang, Yuqi Zhu, Jingna Xun, Liang Yue, Qinru Lin, Huitong Liang, Min Li, Huanzhang Zhu

International Journal of Molecular Sciences

DOI

2023

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo

Hanyu Pan, Xinyi Yang, Jing Wang, Huitong Liang, Zhengtao Jiang, Lin Zhao, Yanan Wang, Zhiming Liang, Xiaoting Shen, Qinru Lin, Yue Liang, Jinglong Yang, Panpan Lu, Yuqi Zhu, Min Li, Pengfei Wang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Virologica Sinica

DOI

2022

分泌PD-1单链抗体的MesoCAR-T细胞治疗非小细胞肺癌的体内外研究

赵琳，王菁，杨金龙，陆盼盼，王亚楠，杨辛毅，姜正涛，潘晗雨，沈晓婷，粱智铭，朱焕章

《复旦学报(自然科学版)》

2022

我国HIV储存库研究的主要进展

焦艳梅，梁国新，徐建青，毛蕴玉，邓凯，朱焕章，吴昊

《中国艾滋病性病》

2022

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

Yuqi Zhu, Xinyi Yang, Jingna Xun, Jun Liu, Qing Wen, Yixiao Lin, Xiaoting Shen, Jun Chen, Songhua Yuan, Xiaying Zhao, Jing Wang, Hanyu Pan, Jin‐Long Yang, Zhiming Liang, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Jianping Liu, Yinzhong Shen, Xiaoyan Zhang, Pengfei Wang, Daru Lu, Chunhua Yin, Jianqing Xu, Shibo Jiang, Hongzhou Lu, Huanzhang Zhu

Virologica Sinica

DOI

2022

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Jingna Xun, Wen Qin, Hanyu Pan, Jin‐Long Yang, Jing Wang, Zhimin Liang, Xiaoting Shen, Liang Yue, Qinru Lin, Huitong Liang, Min Li, Jun Chen, Shibo Jiang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Emerging Microbes & Infections

DOI

2022

Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification

Xiaoting Shen, Qinru Lin, Zhiming Liang, Jing Wang, Xinyi Yang, Yue Liang, Huitong Liang, Hanyu Pan, Jinlong Yang, Yuqi Zhu, Min Li, Weirong Xiang, Huanzhang Zhu

The CRISPR Journal

DOI

2022

EK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice

Panpan Lu, Jinlong Yang, Xinyi Yang, Zhiming Liang, Jing Wang, Yanan Wang, Lin Zhao, Hanyu Pan, Xiaoting Shen, Yuqi Zhu, Jingna Xun, Hongzhou Lu, Huanzhang Zhu

Nanotheranostics

DOI

2022

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Yanjia Chen, Xiaoyu Zhao, Hao Zhou, Huanzhang Zhu, Shibo Jiang, Pengfei Wang

Nature reviews. Immunology

DOI

2022

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

Xinyi Yang, Yuqi Zhu, Jingna Xun, Jun Liu, Qing Wen, Yixiao Lin, Xiaoting Shen, Jun Chen, Songhua Yuan, Xiaying Zhao, Jing Wang, Hanyu Pan, Jin‐Long Yang, Zhiming Liang, Yue Liang, Qinru Lin, Huitong Liang, Chunyan Zhou, Jin Li, Weijian Xie, Jianping Liu, Daru Lu, Tianlei Ying, Yinzhong Shen, Xiaoyan Zhang, Jianqing Xu, Chunhua Yin, Pengfei Wang, Shibo Jiang, Hongzhou Lu, Huanzhang Zhu

iScience

DOI

2022

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

Xun Wang, Xiaoyu Zhao, Jieyu Song, Jing Wu, Yuqi Zhu, Minghui Li, Yuchen Cui, Yanjia Chen, Lulu Yang, Jun Liu, Huanzhang Zhu, Shibo Jiang, Pengfei Wang

Emerging Microbes & Infections

DOI

2021

基因编辑技术对抗潜伏的艾滋病病毒

朱豫琪，潘晗雨，朱焕章

《张江科技评论》

2021

HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

Zhengtao Jiang, Huitong Liang, Hanyu Pan, Liang Yue, Hua Wang, Xinyi Yang, Panpan Lu, Xiao Zhang, Jinlong Yang, Dengji Zhang, Xiaoting Shen, Jing Wang, Zhiming Liang, Qinru Lin, Yanan Wang, Lin Zhao, Yangcheng Zhong, Hongzhou Lu, Huanzhang Zhu

Frontiers in Microbiology

DOI

2021

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

Xinyi Yang, Xiaying Zhao, Yuqi Zhu, Yinzhong Shen, Yanan Wang, Panpan Lu, Zhengtao Jiang, Hanyu Pan, Jinlong Yang, Jingna Xun, Lin Zhao, Jing Wang, Zhiming Liang, Xiaoting Shen, Liang Yue, Qinru Lin, Huitong Liang, Lu Jin, Dengji Zhang, Jun Liu, Bin Wang, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Huanzhang Zhu

mBio

DOI

2021

Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model

Yanan Wang, Jing Wang, Xinyi Yang, Jinlong Yang, Panpan Lu, Lin Zhao, Bokang Li, Hanyu Pan, Zhengtao Jiang, Xiaoting Shen, Zhiming Liang, Yue Liang, Huanzhang Zhu

Frontiers in Immunology

DOI

2020

PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling

Xinyi Yang, Yanan Wang, Panpan Lu, Yinzhong Shen, Xiaying Zhao, Yuqi Zhu, Zhengtao Jiang, He Bei Yang, Hanyu Pan, Lin Zhao, Yangcheng Zhong, Jing Wang, Zhiming Liang, Xiaoting Shen, Daru Lu, Shibo Jiang, Jianqing Xu, Hao Wu, Hongzhou Lu, Guochun Jiang, Huanzhang Zhu

EMBO Reports

DOI

2019

Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections

He Bei Yang, Xian Li, Xinyi Yang, Panpan Lu, Yanan Wang, Zhengtao Jiang, Hanyu Pan, Lin Zhao, Yuqi Zhu, Inam Ullah Khan, Yinzhong Shen, Hongzhou Lu, Tong Zhang, Guochun Jiang, Zhongjun Ma, Hao Wu, Huanzhang Zhu

Antiviral Research

DOI

2018

荧光素酶表达的淋巴瘤NCG小鼠模型的构建

钟杨城，陆盼盼，王亚楠，姜正涛，杨辛毅，杨鹤，潘含雨，赵琳，李博康，周牧涯，朱焕章

《复旦学报(自然科学版)》

2018

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells

Haiyan Ji, Panpan Lu, Baochi Liu, Xiying Qu, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, He Bei Yang, Hanyu Pan, Lin Zhao, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Molecular Therapy — Nucleic Acids

DOI

2017

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

Panpan Lu, Yinzhong Shen, He Bei Yang, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, Hanyu Pan, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Scientific Reports

DOI

2017

The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells

Hanyu Pan, Panpan Lu, Yinzhong Shen, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, He Bei Yang, Inam Ulla Khan, Muya Zhou, Bokang Li, Ziyu Zhang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Oncotarget

DOI

2017

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui

Pengfei Wang, Panpan Lu, Xiying Qu, Yinzhong Shen, Hanxian Zeng, Xiaoli Zhu, Yuqi Zhu, Xian Li, Hao Wu, Jianqing Xu, Hongzhou Lu, Zhongjun Ma, Huanzhang Zhu

Scientific Reports

DOI

2017

Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1

Junxiao Deng, Xiying Qu, Panpan Lu, Xinyi Yang, Yuqi Zhu, Haiyan Ji, Yanan Wang, Zhengtao Jiang, Xian Li, Yangcheng Zhong, He Bei Yang, Hanyu Pan, Won‐Bin Young, Huanzhang Zhu

Molecular Therapy — Nucleic Acids

DOI

2017

Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB

Xinyi Yang, Xiaoli Zhu, Haiyan Ji, Junxiao Deng, Panpan Lu, Zhengtao Jiang, Xian Li, Yibo Wang, Chuqiao Wang, Jingya Zhao, Yanan Wang, Yangcheng Zhong, He Bei Yang, Huanzhang Zhu

Molecular Medicine Reports

DOI

2016

Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter

Haiyan Ji, Zhengtao Jiang, Panpan Lu, Li Ma, Chuan Li, Hanyu Pan, Zheng Fu, Xiying Qu, Pengfei Wang, Junxiao Deng, Xinyi Yang, Jianhua Wang, Huanzhang Zhu

Molecular Therapy

DOI

2016

Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone

Xian Li, Hanxian Zeng, Pengfei Wang, Lin Lü, Lin Liu, Pinyi Zhen, Yuanzhe Fu, Panpan Lu, Huanzhang Zhu

Current HIV Research

DOI

2016

The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb

Panpan Lu, Xiying Qu, Yinzhong Shen, Zhengtao Jiang, Pengfei Wang, Hanxian Zeng, Haiyan Ji, Junxiao Deng, Xinyi Yang, Xian Li, Hongzhou Lu, Huanzhang Zhu

Scientific Reports

DOI

2016

Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4 + T Cells

Chuan Li, Haibo Wang, Wen-Dong Kuang, Xiaoxin Ren, Shu-Ting Song, Huan-zhang Zhu, Qiang Li, Li-Ran Xu, Hui-Jun Guo, Li Juan Wu, Jian‐Hua Wang

Journal of Virology

DOI

2015

基因编辑技术在基因治疗中的应用进展

季海艳，朱焕章

《生命科学》

2015

Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency

Pengfei Wang, Xiying Qu, Xin Zhou, Yinzhong Shen, Haiyan Ji, Zheng Fu, Junxiao Deng, Panpan Lu, Wenbo Yu, Hongzhou Lu, Huanzhang Zhu

Virology

DOI

2015

TRIM5 α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis

Junxiao Deng, Yan Chen, Donglin Ding, Panpan Lu, Xinyi Yang, Zhishuo Song, Huanzhang Zhu

AIDS Research and Human Retroviruses

DOI

2015

Progress of genome editing approaches towards gene therapy

Haiyan Ji, Huanzhang Zhu

2014

组蛋白去乙酰化酶抑制剂MS275对HIV潜伏细胞株激活效应的初步研究

王晓辉，杨少宗，朱豫琪，曲喜英，王鹏飞，曾汉献，朱晓莉，朱焕章

《复旦学报(自然科学版)》

2014

Dilazep synergistically reactivates latent HIV-1 in latently infected cells

Hanxian Zeng, Sijie Liu, Pengfei Wang, Xiying Qu, Haiyan Ji, Xiaohui Wang, Xiaoli Zhu, Zhishuo Song, Xinyi Yang, Zhongjun Ma, Huanzhang Zhu

Molecular Biology Reports

DOI

2014

Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation

Xiaoli Zhu, Sijie Liu, Pengfei Wang, Xiying Qu, Xiaohui Wang, Hanxian Zeng, Huabiao Chen, Huanzhang Zhu

Biochemical and Biophysical Research Communications

DOI

2014

Designed Transcription Activator-Like Effector Proteins Efficiently Induced the Expression of Latent HIV-1 in Latently Infected Cells

Xiaohui Wang, Pengfei Wang, Zheng Fu, Haiyan Ji, Xiying Qu, Hanxian Zeng, Xiaoli Zhu, Junxiao Deng, Panpan Lu, Shijun Zha, Zhishuo Song, Huanzhang Zhu

AIDS Research and Human Retroviruses

DOI

2014

Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells

Xiying Qu, Pengfei Wang, Donglin Ding, Xiaohui Wang, Gongmin Zhang, Xin Zhou, Lin Liu, Xiaoli Zhu, Hanxian Zeng, Huanzhang Zhu

Molecular Biology Reports

DOI

2014

Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter

P Wang, Xin Qu, Xu‐Wen Wang, Xiaoli Zhu, H Zeng, Huabiao Chen, Huanzhang Zhu

Gene Therapy

DOI

2013

野生型及突变型HIV-1 LTR驱动的荧光素酶稳定表达细胞株的建立

刘林，杨少宗，林师冠，王晓辉，孔垂瑾，曲喜英，朱焕章

《复旦学报(自然科学版)》

2013

As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB

Pengfei Wang, Xiying Qu, Xiaohui Wang, Lin Liu, Xiaoli Zhu, Hanxian Zeng, Huanzhang Zhu

Antiviral Research

DOI

2013

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

Xiying Qu, Pengfei Wang, Donglin Ding, Lin Li, Haibo Wang, Li Ma, Xin Zhou, Shaohui Liu, Shiguan Lin, Xiaohui Wang, Gongmin Zhang, Sijie Liu, Lin Liu, Jian‐Hua Wang, Feng Zhang, Daru Lu, Huanzhang Zhu

Nucleic Acids Research

DOI

2013

Histone Deacetylase Inhibitor MC1293 Induces Latent HIV-1 Reactivation by Histone Modification In Vitro Latency Cell Lines

Xiying Qu, Hao Ying, Xiaohui Wang, Chuijin Kong, Xin Zhou, Pengfei Wang, Huanzhang Zhu

Current HIV Research

DOI

2013

Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation

Donglin Ding, Xiying Qu, Lin Li, Xin Zhou, Sijie Liu, Shiguan Lin, Pengfei Wang, Shaohui Liu, Chuijin Kong, Xiaohui Wang, Lin Liu, Huanzhang Zhu

Virology

DOI

2013

Screening of potential pseudo att sites of Streptomyces phage ΦC31 integrase in the human genome

Zhipeng Hu, Lusheng Chen, Cai-yan Jia, Huanzhang Zhu, Wei Wang, Jiang Shi Zhong

Acta Pharmacologica Sinica

DOI

2012

Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB

Hao Ying, Yuhao Zhang, Xin Zhou, Xiying Qu, Pengfei Wang, Sijie Liu, Daru Lu, Huanzhang Zhu

PLoS ONE

DOI

2012

In Vitro Infection of Human Umbilical Cord Blood CD34+ Hematopoietic Progenitor Cells by HIV-1 CRF07_BC Enveloped Pseudovirus

Lin Li, Chao Qiu, Liangzhu Li, Aiping Liu, Mingzhe Zhou, Zhimin Han, Chenli Qiu, Xiaoyan Zhang, Jianqing Xu, Huanzhang Zhu

Current HIV Research

DOI

2012

Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis

SiJie Liu, Chuijin Kong, Jie Wu, Hao Ying, Huanzhang Zhu

PLoS ONE

DOI

2011

HIV-1潜伏感染人Jurkat T细胞模型的建立

李琳，仇超，李亮助，刘爱平，邱趁丽，周明哲，张晓燕，徐建青，朱焕章

《中国艾滋病性病》

2011

HIV-1 Reactivation Induced by Apicidin Involves Histone Modification in Latently Infected Cells

Shiguan Lin, Yuhao Zhang, Hao Ying, Huanzhang Zhu

Current HIV Research

DOI

2011

Association Between Polymorphism of SDF1 (CXCL12) Gene and HIV-1 Susceptibility: A Meta-Analysis

SiJie Liu, Huanzhang Zhu

Current HIV Research

DOI

2011

HIV-1 Co-Receptor Usage Based on V3 Loop Sequence Analysis: Preferential Suppression of CXCR4 Virus Post HAART?

Yanmei Jiao, Pengfei Wang, Hongwei Zhang, Tong Zhang, Yonghong Zhang, Huanzhang Zhu, Hao Wu

Immunological Investigations

DOI

2010

HIV/AIDS治疗研究进展

王鹏飞，焦艳梅，朱焕章，吴昊

《首都医科大学学报》

2010

扩增潜伏HIV-1 DNA序列实验方法的优化

王鹏飞，焦艳梅，朱焕章，吴昊

《北京医学》

DOI

2010

ΦC31位点特异性整合酶DNA结合功能域的鉴定

辛清婷，马金芳，王玮，刘绍辉，李荣秀，朱焕章

《中国生物化学与分子生物学报》

2010

Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells

Hao Yin, Yuhao Zhang, Xin Zhou, Huanzhang Zhu

Molecular Biology Reports

DOI

2010

CCL3L1 Copy Number Variation and Susceptibility to HIV-1 Infection: A Meta-Analysis

SiJie Liu, Lei Yao, Donglin Ding, Huanzhang Zhu

PLoS ONE

DOI

2010

Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysis

Huanzhang Zhu

Molecular Medicine Reports

DOI

2010

Histone deacetylase inhibition allows latent HIV-1 promoter activity by inducing histone modification in latently infected cells

Hao Yin, Yuhao Zhang, Yefei Han, Huanzhang Zhu

Journal of Biotechnology

DOI

2010

Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination

Shaohui Liu, Jinfang Ma, Wei Wang, Maoxiang Zhang, Qingting Xin, Siman Peng, Rongxiu Li, Huan-zhang Zhu

PLoS ONE

DOI

2009

TAT-phiC31 integrase mediates DNA recombination in mammalian cells

Mao-xiang Zhang, Zhihui Li, Yuxiang Fang, Huan-zhang Zhu, Jinglun Xue, Jinzhong Chen, William W.-G. Jia

Journal of Biotechnology

DOI

2008

Eliminating bacteria backbone of naked DNA enhanced hFIX expression and reduced inflammatory response in mice

Huan-zhang Zhu, Hong‐Yan Chen, Deng‐Min Feng, Qi Shen, Jinglun Xue, William W.-G. Jia

Biomedicine & Pharmacotherapy

DOI

2006

Construction of an infectious cDNA clone of Ribgrass mosaic virus Shanghai isolate and its modification to express an epitope of Mycobacterium tuberculosis

Huanzhang Zhu, J.-P. Chen, S. Q. Yu

Archives of Virology

DOI

2006

A 16 bp Rep Binding Element is Sufficient for Mediating Rep-dependent Integration into AAVS1

Deng‐Min Feng, Jinzhong Chen, Yangbo Yue, Huanzhang Zhu, Jinglun Xue, William W.-G. Jia

Journal of Molecular Biology

DOI

2006

DAXX interacts with phage ΦC31 integrase and inhibits recombination

Jinzhong Chen, Chaoneng Ji, Guanlan Xu, Rong-Yan Pang, Jihua Yao, Huanzhang Zhu, Jinglun Xue, William W.-G. Jia

Nucleic Acids Research

DOI

2004

φC31位点特异性整合酶系统在生物医学上的应用

张文娟，朱焕章，薛京伦

《国际遗传学杂志》

2004

RNA干涉在基因治疗中的应用

王玮，朱焕章，薛京伦

《生物化学与生物物理进展》

2004

Rep蛋白介导的定点整合研究进展

冯登敏，朱焕章，薛京伦

《国际遗传学杂志》

2004

不同重组慢病毒介导人凝血因子ⅨcDNA在血友病B小鼠中表达的影响

宫菊丽，陈晓光，朱焕章，薛京伦

《复旦学报(自然科学版)》

2004

检测Cre位点特异重组酶活性的双报告转基因小鼠建立

朱焕章，陈建泉，成国祥，薛京伦

《陆军军医大学学报》

2003

RNA干扰技术在抗HIV-1感染中的应用

宫菊丽，朱焕章，卢大儒，薛京伦

《国际遗传学杂志》

2003

配体依赖性Cre重组酶在培养肝细胞中介导条件性基因激活(英文)

朱焕章，曹莹莹，成国祥，薛京伦

Acta Biochimica et Biophysica Sinica

2003

Expression of human clotting factor IX mediated by recombinant lentiviral vector in cultured cells and hemophilia B mice

Huanzhang Zhu, Xiaoguang Chen, Feng Li, Ju-li Gong, Jinglun Xue

Chinese Science Bulletin

DOI

2003

Transgenic mice expressing hepatitis B virus X protein are more susceptible to carcinogen induced hepatocarcinogenesis

Huanzhang Zhu, Yun Wang, Jianquan Chen, Guoxiang Cheng, Jinglun Xue

Experimental and Molecular Pathology

DOI

2003

Conditional gene activation in cultured hepatocytes using a ligand-dependent chimeric Cre recombinase.

Huanzhang Zhu, Yingying Cao, Guo-Xiang Cheng, Jinglun Xue

PubMed

2000

Cre/LoxP系统在转基因小鼠上的应用策略

朱焕章，史景泉，public.cta.cq.cn

《生物化学与生物物理进展》

1999

乙型肝炎病毒X基因转基因小鼠的初步建立

朱焕章，史景泉，成国祥，陈建泉，旷双运，孙强，成勇，张新立，李厚达，徐少甫，钱耕荪，顾建人

《陆军军医大学学报》

1997

突变型p53蛋白在二乙基亚硝胺诱发大鼠肝癌前病变中的表达

朱焕章，张新立，陈意生

《中华肿瘤杂志》

1996

胎盘型谷胱甘肽S转移酶mRNA在大鼠肝癌癌前病变组织中的原位表达

朱焕章，张新立，陈意生

《陆军军医大学学报》

精选作品

期刊论文

Preparation, Oral SNEDDS Formulation, and In Vivo Evaluation of the HIV-1 Latency-Reversing Agent EK-16A

Validation of CCL20-driven CAR-γδ T secreting PD-1 blockade with enhanced trafficking into solid tumor

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

小分子药物提高慢病毒对人γδ T细胞感染效率的研究

一种高活性γδ T细胞的体外培养方案

Effective in vivo reactivation of HIV-1 latency reservoir via oral administration of EK-16A-SNEDDS

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

腺相关病毒介导锌指核酸酶体外切除HIV-1基因组研究

Scopoletin Reactivates Latent HIV-1 by Inducing NF-κB Expression without Global T Cell Activation

Chemokine Receptors CCR6 and PD1 Blocking scFv E27 Enhances Anti-EGFR CAR-T Therapeutic Efficacy in a Preclinical Model of Human Non-Small Cell Lung Carcinoma

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo

分泌PD-1单链抗体的MesoCAR-T细胞治疗非小细胞肺癌的体内外研究

我国HIV储存库研究的主要进展

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

Reduction of Pre-Existing Adaptive Immune Responses Against SaCas9 in Humans Using Epitope Mapping and Identification

EK-16A liposomes enhance HIV replication in ACH2 or J-Lat 10.6 cell engrafted NSG mice

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

基因编辑技术对抗潜伏的艾滋病病毒

HIV-1-Specific CAR-T Cells With Cell-Intrinsic PD-1 Checkpoint Blockade Enhance Anti-HIV Efficacy in vivo

FKBP3 Induces Human Immunodeficiency Virus Type 1 Latency by Recruiting Histone Deacetylase 1/2 to the Viral Long Terminal Repeat

Chemokine Receptor CCR2b Enhanced Anti-tumor Function of Chimeric Antigen Receptor T Cells Targeting Mesothelin in a Non-small-cell Lung Carcinoma Model

PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF‐κB signaling

Dual effects of the novel ingenol derivatives on the acute and latent HIV-1 infections

荧光素酶表达的淋巴瘤NCG小鼠模型的构建

Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

The bromodomain and extraterminal domain inhibitor bromosporine synergistically reactivates latent HIV-1 in latently infected cells

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui

Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1

Quercetin synergistically reactivates human immunodeficiency virus type 1 latency by activating nuclear factor‑κB

Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter

Reactivation of latent HIV-1 in latently infected cells by coumarin compounds: Hymecromone and ScoparoneReactivation of Latent HIV-1 in Latently Infected Cells by Coumarin Compounds: Hymecromone and Scoparone

The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb

Naf1 Regulates HIV-1 Latency by Suppressing Viral Promoter-Driven Gene Expression in Primary CD4 + T Cells

基因编辑技术在基因治疗中的应用进展

Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency

TRIM5 α H43Y Polymorphism and Susceptibility to HIV-1 Infection: A Meta-Analysis

Progress of genome editing approaches towards gene therapy

组蛋白去乙酰化酶抑制剂MS275对HIV潜伏细胞株激活效应的初步研究

Dilazep synergistically reactivates latent HIV-1 in latently infected cells

Oxaliplatin antagonizes HIV-1 latency by activating NF-κB without causing global T cell activation

Designed Transcription Activator-Like Effector Proteins Efficiently Induced the Expression of Latent HIV-1 in Latently Infected Cells

Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells

Specific reactivation of latent HIV-1 with designer zinc-finger transcription factors targeting the HIV-1 5′-LTR promoter

野生型及突变型HIV-1 LTR驱动的荧光素酶稳定表达细胞株的建立

As2O3 synergistically reactivate latent HIV-1 by induction of NF-κB

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

Histone Deacetylase Inhibitor MC1293 Induces Latent HIV-1 Reactivation by Histone Modification In Vitro Latency Cell Lines

Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation

Screening of potential pseudo att sites of Streptomyces phage ΦC31 integrase in the human genome

Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB

In Vitro Infection of Human Umbilical Cord Blood CD34+ Hematopoietic Progenitor Cells by HIV-1 CRF07_BC Enveloped Pseudovirus

Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis

HIV-1潜伏感染人Jurkat T细胞模型的建立

HIV-1 Reactivation Induced by Apicidin Involves Histone Modification in Latently Infected Cells

Association Between Polymorphism of SDF1 (CXCL12) Gene and HIV-1 Susceptibility: A Meta-Analysis

HIV-1 Co-Receptor Usage Based on V3 Loop Sequence Analysis: Preferential Suppression of CXCR4 Virus Post HAART?

HIV/AIDS治疗研究进展

扩增潜伏HIV-1 DNA序列实验方法的优化

ΦC31位点特异性整合酶DNA结合功能域的鉴定

Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells

CCL3L1 Copy Number Variation and Susceptibility to HIV-1 Infection: A Meta-Analysis

Association between the CCR2-Val64Ile polymorphism and susceptibility to HIV-1 infection: a meta-analysis

Histone deacetylase inhibition allows latent HIV-1 promoter activity by inducing histone modification in latently infected cells

Mutational Analysis of Highly Conserved Residues in the Phage PhiC31 Integrase Reveals Key Amino Acids Necessary for the DNA Recombination

TAT-phiC31 integrase mediates DNA recombination in mammalian cells

Eliminating bacteria backbone of naked DNA enhanced hFIX expression and reduced inflammatory response in mice

Construction of an infectious cDNA clone of Ribgrass mosaic virus Shanghai isolate and its modification to express an epitope of Mycobacterium tuberculosis

A 16 bp Rep Binding Element is Sufficient for Mediating Rep-dependent Integration into AAVS1

DAXX interacts with phage ΦC31 integrase and inhibits recombination

φC31位点特异性整合酶系统在生物医学上的应用

RNA干涉在基因治疗中的应用

Rep蛋白介导的定点整合研究进展

不同重组慢病毒介导人凝血因子ⅨcDNA在血友病B小鼠中表达的影响

检测Cre位点特异重组酶活性的双报告转基因小鼠建立