任芳丽｜清华大学｜学者主页

2026

Opposing Roles of CREPT and p15RS in Tumorigenesis via Differential Regulation of Wnt Signaling

Dekang Zhou, Li J, Fangli Ren, Yajun Cao, Bobin Ning, Wenchen Wang, Baoqing Jia, Guo‐Min Li, Yinyin Wang, Zhijie Chang

Cancers

2026

Correction: Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A

Jingya Li, Mengdi Li, Mengdi Li, Wenchen Wang, Guancheng Jiang, Yinyin Wang, Jianqiu Sheng, Jian Sheng, Zhijie Chang, Jian Sheng, Jian Sheng, Mingyang Li, Mingyang Li, Fangli Ren

Cancer Gene Therapy

DOI

2026

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

Dezhi Wang, Xingchen Liao, Yilin Wang, Xuexin Wang, Heng Zhang, Jie Zeng, Mingjie Zhang, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Wenchen Wang, Qing Lin, Lingyun Gu, Zhijie Chang, Jianqiu Sheng

MedComm

DOI

2025

Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A

Jingya Li, Mengdi Li, Mengdi Li, Wenchen Wang, Guancheng Jiang, Yinyin Wang, Jianqiu Sheng, Jianqiu Sheng, Zhijie Chang, Jian Sheng, Jian Sheng, Mingyang Li, Mingyang Li, Fangli Ren

Cancer Gene Therapy

DOI

2025

CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription

Mengdi Li, Yu-Ting Lin, Jiayu Wang, Yang He, Danhui Ma, Ye Tian, Yi Wang, Yang Liu, Umar Farooq, Yinyin Wang, Fangli Ren, Jian Sheng, Guoqing Zhang, Liang Chen, Jun Li, Xiangnan Li, Zhijie Chang

Theranostics

DOI

2025

Regulation of revival stem cell differentiation by CREPT/RPRD1B during intestinal regeneration

Tingwei Lan, Mengdi Li, Xiaolin Duan, Huihui Jia, Yajun Cao, Yinyin Wang, Fangli Ren, Jianqiu Sheng, Junfeng Xu, Zhijie Chang

Cell & Bioscience

DOI

2025

CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

Jianghua Li, Jianghua Li, Lu Xu, Xuning Wang, Xuning Wang, Yuting Lin, Aixue Zou, Fangli Ren, Yinyin Wang, Jun Li, Jun Li, Zhijie Chang

Molecular Cancer

DOI

2025

Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia

Xingchen Liao, Xuexin Wang, Xin Wang, Mingjie Zhang, Fangli Ren, Dezhi Wang, Jianqiu Sheng

Scientific Reports

DOI

2025

DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation

Zhen-Mei Song, Xuexin Wang, Jie Zeng, Fangli Ren, Yinyin Wang, Meng Li, Qing Lin, Wenli Li, Xingchen Liao, Dezhi Wang

Journal of Lipid Research

DOI

2024

An oncoprotein CREPT functions as a co-factor in MYC-driven transformation and tumor growth

Mengdi Li, Jingya Li, Chunhua He, Guancheng Jiang, Danhui Ma, Haipeng Guan, Yu-Ting Lin, Meng Li, Jing Jia, Xiaolin Duan, Yinyin Wang, Fangli Ren, Haitao Li, Xiaoguang Wang, Chenxi Cao, Zhijie Chang

Journal of Biological Chemistry

DOI

2024

RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

Lu Xu, Zhihao Xie, Jun Li, Shi Tao, Fangli Ren, Yinyin Wang, Zhijie Chang, Xinbao Hao

Asian Pacific Journal of Tropical Biomedicine

DOI

2024

Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis

Meng Li, Jun Li, Ying Wang, Guancheng Jiang, Hanguo Jiang, Mengdi Li, Ziying Zhu, Fangli Ren, Yinyin Wang, Muyang Yan, Zhijie Chang

Stem Cell Research & Therapy

DOI

2024

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury

Minghan Wang, Bin Wu, Kaiyang Tang, Xuexin Wang, Xinyan Liu, Yinan Duan, Jiayu Wang, Xiaoguang Wang, Yinyin Wang, Jun Li, Chenxi Cao, Fangli Ren, Zhijie Chang

Toxics

DOI

2024

Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation

Dezhi Wang, Heng Zhang, Xingchen Liao, Jun Li, Jie Zeng, Yilin Wang, Mingjie Zhang, Xianzong Ma, Xin Wang, Fangli Ren, Yinyin Wang, Meng Li, Junfeng Xu, Peng Jin, Jianqiu Sheng

Journal of Nanobiotechnology

DOI

2023

Microenvironment-induced CREPT expression by cancer-derived small extracellular vesicles primes field cancerization

Yu-Ting Lin, Hanguo Jiang, Jun Li, Fangli Ren, Yinyin Wang, Ying Qiu, Jianghua Li, Mengdi Li, Ying Wang, Yang Liu, Yunhao Song, Huihui Jia, Wanli Zhai, Yanshen Kuang, Hanyang Yu, Wen‐Yuan Zhu, Suling Liu, Eiichi Morii, Christian Ensinger, Charles J. David, Hanqiu Zheng, Jianguo Ji, Hongxia Wang, Zhijie Chang

Theranostics

DOI

2023

Lachnochromonin, a fungal metabolite from Lachnum virgineum, inhibits cell growth and promotes apoptosis in tumor cells through JAK/STAT3 signaling

Jun Chu, Wanli Zhai, Yongtao Geng, Yarui Feng, Jiayu Wang, Jun Li, Yinyin Wang, Wen-Ying Zhuang, Yongsheng Che, Yi Li, Zhijie Chang, Fangli Ren

Cellular Signalling

DOI

2022

CREPT Disarms the Inhibitory Activity of HDAC1 on Oncogene Expression to Promote Tumorigenesis

Yajun Cao, Bobin Ning, Ye Tian, Tingwei Lan, Yunxiang Chu, Fangli Ren, Yinyin Wang, Qingyu Meng, Jun Li, Baoqing Jia, Zhijie Chang

Cancers

DOI

2022

Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells

Yanxia Fu, Jun Li, Ziyu Zhang, Fangli Ren, Yinyin Wang, Huihui Jia, Yihe Liu, Zhijie Chang

FEBS Letters

DOI

2022

Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages

Yanxia Fu, Jun Li, Mengdi Li, Junfeng Xu, Zheng Rong, Fangli Ren, Yinyin Wang, Jianqiu Sheng, Zhijie Chang

Stem Cells International

DOI

2021

CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner

Wanli Zhai, Xiongjun Ye, Yinyin Wang, Yarui Feng, Ying Wang, Yu-Ting Lin, Lidan Ding, Yang Liu, Xuning Wang, Yanshen Kuang, Xin-Yuan Fu, Yue Eugene Chin, Baoqing Jia, Bingtao Zhu, Fangli Ren, Zhijie Chang

British Journal of Cancer

DOI

2021

CREPT is required for murine stem cell maintenance during intestinal regeneration

Yang Liu, Haiyan Yang, Yunxiang Chu, Yunhao Song, Lidan Ding, Bingtao Zhu, Wanli Zhai, Xuning Wang, Yanshen Kuang, Fangli Ren, Baoqing Jia, Wei Wu, Xiongjun Ye, Yinyin Wang, Zhijie Chang

Nature Communications

DOI

2021

IL‐17RD/sef exacerbates experimental mouse colitis and inflammation‐associated tumorigenesis by regulating the proportion of T cell subsets

Yanxia Fu, Sihan Liu, Mengdi Li, Fangli Ren, Yinyin Wang, Zhijie Chang

FEBS Letters

DOI

2020

A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering

Sihan Liu, Yanxia Fu, Kunrong Mei, Yinan Jiang, Xiaojun Sun, Yinyin Wang, Fangli Ren, Congshan Jiang, Liesu Meng, Shemin Lu, Zhihai Qin, Chen Dong, Xinquan Wang, Zhijie Chang, Shigao Yang

Cellular and Molecular Immunology

DOI

2019

GdX/UBL4A‐knockout mice resist collagen‐induced arthritis by balancing the population of T h 1/T h 17 and regulatory T cells

Yanxia Fu, Sihan Liu, Yinyin Wang, Fangli Ren, Xuanzi Fan, Jiao Liang, Chunxiao Liu, Jun Li, Yanfang Ju, Zhijie Chang

The FASEB Journal

DOI

2019

Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells

Chunxiao Liu, Yifan Zhou, Mengdi Li, Ying Wang, Yang Liu, Shigao Yang, Yarui Feng, Yinyin Wang, Yangmeng Wang, Fangli Ren, Jun Li, Zhongjun Dong, Yue Eugene Chin, Xin-Yuan Fu, Wu Li, Zhijie Chang

Theranostics

DOI

2018

CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer

Lidan Ding, Yang Liu, Yuqi He, Bingtao Zhu, Fangli Ren, Xuanzi Fan, Yinyin Wang, Mengdi Li, Jun Li, Yanshen Kuang, Sihan Liu, Wanli Zhai, Danhui Ma, Yanfang Ju, Quentin Liu, Baoqing Jia, Jianqiu Sheng, Zhijie Chang

Cell Death and Disease

DOI

2018

MicroRNA‐383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression

Jian Li, Amber Rae Smith, Rebecca T. Marquez, Jun Li, Kun Li, Lan Lan, Xiaoqing Wu, Linxi Zhao, Fangli Ren, Yi Wang, Yinyin Wang, Baoqing Jia, Liang Xu, Zhijie Chang

Molecular Carcinogenesis

DOI

2018

CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation

Yanquan Zhang, Shiyan Wang, Wei Kang, Chunxiao Liu, Yujuan Dong, Fangli Ren, Yinyin Wang, Jinglin Zhang, Guoping Wang, Ka Fai To, Xueji Zhang, Joseph J.�Y. Sung, Zhijie Chang, Jun Qing Yu

Oncogene

DOI

2018

Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling

Xuanzi Fan, Juan Zhao, Fangli Ren, Yinyin Wang, Yarui Feng, Lidan Ding, Linpeng Zhao, Yu Shang, Jun Li, Jian‐Quan Ni, Baoqing Jia, Yule Liu, Zhijie Chang

Journal of Biological Chemistry

DOI

2015

Nuclear termination of STAT3 signaling through SIPAR (STAT3‐Interacting Protein As a Repressor)‐dependent recruitment of T cell tyrosine phosphatase TC‐PTP

Fangli Ren, Yongtao Geng, Takayuki Minami, Ying Qiu, Yarui Feng, Chunxiao Liu, Juan Zhao, Yinyin Wang, Xuanzi Fan, Yangmeng Wang, Mengdi Li, Jun Li, Zhijie Chang

FEBS Letters

DOI

2015

p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway

Chunxiao Liu, Yanquan Zhang, Jun Li, Yinyin Wang, Fangli Ren, Yifan Zhou, Yinyuan Wu, Yarui Feng, Yu Jerry Zhou, Fuqin Su, Baoqing Jia, Dong Wang, Zhijie Chang

Journal of Biological Chemistry

DOI

2014

Characterization of a Monoclonal Antibody Against CREPT, a Novel Protein Highly Expressed in Tumors

Fangli Ren, Ruoke Wang, Yanquan Zhang, Chunxiao Liu, Yinyin Wang, Jim Hu, Linqi Zhang, Zhijie Chang

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

DOI

2014

CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling

Yanquan Zhang, Chunxiao Liu, Xiaolin Duan, Fangli Ren, Shan Li, Zhe Hu Jin, Yinyin Wang, Yarui Feng, Zewen Liu, Zhijie Chang

Journal of Biological Chemistry

DOI

2014

GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis

Yangmeng Wang, Hongxiu Ning, Fangli Ren, Yuanjiang Zhang, Yu Rong, Yinyin Wang, Fuqin Su, Chenguang Cai, Zhe Hu Jin, Zhiyong Li, Xinqi Gong, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Ying Qiu, Yasuhiko Tomita, Joseph J.�Y. Sung, Jun Qing Yu, David M. Irwin, Xiao Yi Yang, Xin-Yuan Fu, Y. Eugene Chin, Zhijie Chang

Molecular Cell

DOI

2014

CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma.

Yaoguang She, Jiao Liang, Lin Chen, Ying Qiu, Na Liu, Xudong Zhao, Xiaohui Huang, Yinyin Wang, Fangli Ren, Zhijie Chang, Peiyu Li

PubMed

2014

Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS

Kunrong Mei, Zhe Hu Jin, Fangli Ren, YinYing Wang, Zhijie Chang, Xinquan Wang

Science China Life Sciences

DOI

2014

Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation

Shigao Yang, Yinyin Wang, Kunrong Mei, Sen Zhang, Xiaojun Sun, Fangli Ren, Sihan Liu, Zi F. Yang, Xinquan Wang, Zhihai Qin, Zhijie Chang

Journal of Biological Chemistry

DOI

2014

Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2

Yongtao Geng, Yanfang Ju, Fangli Ren, Ying Qiu, Yasuhiko Tomita, Miki Tomoeda, Mioka Kishida, Yinyin Wang, Lian Hai Jin, Fuqin Su, Chunhong Wei, Baoqing Jia, Yi Li, Zhijie Chang

Journal of Biological Chemistry

DOI

2013

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma

Fangli Ren, Fuqin Su, Hongxiu Ning, Yangmeng Wang, Yongtao Geng, Yarui Feng, Yinyin Wang, Yanquan Zhang, Zhe Hu Jin, Yi Li, Baoqing Jia, Zhijie Chang

Cellular Signalling

DOI

2013

Activation of TAK1 by Sef-S induces apoptosis in 293T cells

Xiaojun Sun, Yinyin Wang, Shigao Yang, Fangli Ren, Yongjing Xia, Zhijie Chang

Cellular Signalling

DOI

2012

CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes

Dongdong Lu, Yinyuan Wu, Yinyin Wang, Fangli Ren, Dianjun Wang, Fuqin Su, Yanquan Zhang, Xi Yang, Guihua Jin, Xinbao Hao, Dacheng He, Yonggong Zhai, David M. Irwin, Jim Hu, Joseph J.�Y. Sung, Jun Qing Yu, Baoqing Jia, Zhijie Chang

Cancer Cell

DOI

2012

Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer

Fuqin Su, Fangli Ren, Yu Rong, Yangmeng Wang, Yongtao Geng, Yinyin Wang, Mengyao Feng, Yanfang Ju, Yi Li, Zhizhuang Joe Zhao, Kun Meng, Zhijie Chang

Breast Cancer Research

DOI

2011

Generation of mice with conditional null allele for GdX/Ubl4A

Yangmeng Wang, Dianjun Wang, Fangli Ren, Yuanjiang Zhang, Fuyu Lin, Ning Hou, Xuan Cheng, Peng Zhang, Yinyin Wang, Baoqing Jia, Xiao Yi Yang, Zhijie Chang

genesis

DOI

2011

GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

Yanquan Zhang, Fang Wang, Liang Han, Yinyuan Wu, Shan Li, Xi Yang, Yinyin Wang, Fangli Ren, Yonggong Zhai, Dianjun Wang, Baoqing Jia, Yongjing Xia, Zhijie Chang

Cellular Physiology and Biochemistry

DOI

2010

p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction

Yinyuan Wu, Yanquan Zhang, Haiwei Zhang, Xi Yang, Yinyin Wang, Fangli Ren, Liu Huitu, Yonggong Zhai, Baoqing Jia, Jun Qing Yu, Zhijie Chang

Journal of Biological Chemistry

DOI

2010

Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/β-catenin complex

Haiwei Zhang, Hui Zhang, Yanquan Zhang, Ser Sue Ng, Fangli Ren, Yingying Wang, Yaqi Duan, Lin Chen, Yonggong Zhai, Qinglong Guo, Zhijie Chang

Cellular Signalling

DOI

2008

IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling

Zhili Rong, Anan Wang, Zhiyong Li, Yongming Ren, Long Cheng, Yinghua Li, Yinyin Wang, Fangli Ren, Xiaoning Zhang, Jim Hu, Zhijie Chang

Cell Research

DOI

精选作品

期刊论文

Opposing Roles of CREPT and p15RS in Tumorigenesis via Differential Regulation of Wnt Signaling

Correction: Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A

Ipriflavone From Aquilaria malaccensis Lam. Exosome‐Like Nanoparticles Targets Prolyl Hydroxylase Domain Protein 2 (PHD2) to Enhance Hypoxia‐Inducible Factor‐α (HIF‐α) Hydroxylation Thereby Alleviating Hypoxia‐Induced Gastrointestinal Mucosal Ferroptosis

Targeted suppression of tumor growth by CREPT promoter-driven diphtheria toxin fragment A

CREPT promotes LUAD progression by enhancing the CDK9 and RNAPII assembly to promote ERK-driven gene transcription

Regulation of revival stem cell differentiation by CREPT/RPRD1B during intestinal regeneration

CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia

DHA and EPA exacerbate hypoxia-induced ferroptosis in gastric and small intestinal mucosa by disrupting the balance between SLC7A11 upregulation and PUFA-PL accumulation

An oncoprotein CREPT functions as a co-factor in MYC-driven transformation and tumor growth

RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis

Cell-Cycle-Related and Expression Elevated Protein in Tumor Upregulates the Antioxidant Genes via Activation of NF-κB/Nrf2 in Acute Liver Injury

Oral administration of Robinia pseudoacacia L. flower exosome-like nanoparticles attenuates gastric and small intestinal mucosal ferroptosis caused by hypoxia through inhibiting HIF-1α- and HIF-2α-mediated lipid peroxidation

Microenvironment-induced CREPT expression by cancer-derived small extracellular vesicles primes field cancerization

Lachnochromonin, a fungal metabolite from Lachnum virgineum, inhibits cell growth and promotes apoptosis in tumor cells through JAK/STAT3 signaling

CREPT Disarms the Inhibitory Activity of HDAC1 on Oncogene Expression to Promote Tumorigenesis

Umbilical cord mesenchymal stem cell‐derived exosomes alleviate collagen‐induced arthritis by balancing the population of Th17 and regulatory T cells

Umbilical Cord Mesenchymal Stem Cells Ameliorate Inflammation-Related Tumorigenesis via Modulating Macrophages

CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner

CREPT is required for murine stem cell maintenance during intestinal regeneration

IL‐17RD/sef exacerbates experimental mouse colitis and inflammation‐associated tumorigenesis by regulating the proportion of T cell subsets

A shedding soluble form of interleukin-17 receptor D exacerbates collagen-induced arthritis through facilitating TNF-α-dependent receptor clustering

GdX/UBL4A‐knockout mice resist collagen‐induced arthritis by balancing the population of T h 1/T h 17 and regulatory T cells

Absence of GdX/UBL4A Protects against Inflammatory Diseases by Regulating NF-кB Signaling in Macrophages and Dendritic Cells

CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer

MicroRNA‐383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression

CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation

Dimerization of p15RS mediated by a leucine zipper–like motif is critical for its inhibitory role on Wnt signaling

Nuclear termination of STAT3 signaling through SIPAR (STAT3‐Interacting Protein As a Repressor)‐dependent recruitment of T cell tyrosine phosphatase TC‐PTP

p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway

Characterization of a Monoclonal Antibody Against CREPT, a Novel Protein Highly Expressed in Tumors

CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling

GdX/UBL4A Specifically Stabilizes the TC45/STAT3 Association and Promotes Dephosphorylation of STAT3 to Repress Tumorigenesis

CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma.

Structural basis for the recognition of RNA polymerase II C-terminal domain by CREPT and p15RS

Tumor Necrosis Factor Receptor 2 (TNFR2)·Interleukin-17 Receptor D (IL-17RD) Heteromerization Reveals a Novel Mechanism for NF-κB Activation

Insulin Receptor Substrate 1/2 (IRS1/2) Regulates Wnt/β-Catenin Signaling through Blocking Autophagic Degradation of Dishevelled2

SIPAR negatively regulates STAT3 signaling and inhibits progression of melanoma

Activation of TAK1 by Sef-S induces apoptosis in 293T cells

CREPT Accelerates Tumorigenesis by Regulating the Transcription of Cell-Cycle-Related Genes

Protein tyrosine phosphatase Meg2 dephosphorylates signal transducer and activator of transcription 3 and suppresses tumor growth in breast cancer

Generation of mice with conditional null allele for GdX/Ubl4A

GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

p15RS Attenuates Wnt/β-Catenin Signaling by Disrupting β-Catenin·TCF4 Interaction

Dishevelled-DEP domain interacting protein (DDIP) inhibits Wnt signaling by promoting TCF4 degradation and disrupting the TCF4/β-catenin complex

IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling

预印本

CREPT is required for pulmonary fibrosis induced by bleomycin

研究方向