尹小英｜上海工程技术大学｜学者主页

2026

基于知识图谱的药物分析课程构建研究

刘书妤，尹小英

《上海化工》

2026

A derivative of cytisine N-isoflavone from Sophora alopecuroides L., suppresses non-small cell lung cancer by targeting mTOR.

Yao-Xuan He, Runge Hu, Y. Lei, Ruiqi Xu, Chengyu Kong, Tong Yu, Da-Min Ding, Hongli Shan, Shu-Xia Jiang, Xiaoying Yin, Yu-Hong Zhou

European Journal of Pharmacology

DOI

2026

A scalable and cost-effective 3D tumor spheroid array chip for distortion-free optical monitoring and drug screening

Yang Lu, Haoran Chen, Xiaoying Yin, Chuanxing Wu, Atta ur Rehman Khan, Rui Xi, Yinan Yan, Jinhao Xu

Biomedical Materials

DOI

2026

Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms

Rui Xi, Xiaoying Yin, Chuangchuang Xiao, Haoran Chen, Yang Lu, Qin Zhao, Daming Shi, Fang-Yun Sun

Molecules

DOI

2025

From reaction energetics to automated analysis tool auxiliary identification: A self-validating multidimensional liquid chromatography- mass spectrometry framework for characterizing polymerized impurities in carbapenem antibiotics.

Fan Wang, R. Mu, Xin Chen, Xiaoying Yin, Fangyu Zhou, Yiren Song, Kexin Guo, Xuan Mao, Haochen Zhai, Tonglin Fan, Zhangyi Chen, Bing-Xing Zhang, Bingqi Zhu, Peilin Yu, Zhi-Hao Xu, Jian Wang, Li-Ya Hong

Journal of Chromatography A

DOI

2025

Molecular Mechanisms of Reversal of Multidrug Resistance in Breast Cancer by Inhibition of P-gp by Cytisine N-Isoflavones Derivatives Explored Through Network Pharmacology, Molecular Docking, and Molecular Dynamics

Chuangchuang Xiao, Xiaoying Yin, Rui Xi, Chunping Yuan, Yang-Sheng Ou

International Journal of Molecular Sciences

DOI

2024

Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration.

Lin-Wei Wang, Xiaoying Yin, Huan Liu, Yang-Yang Wang, Zhi-Xiong Li, Yuxuan Zhao, Haibo Xu, Cheng-Gang Huang, Xing-xing Diao

Journal of Separation Science

DOI

2024

Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery

Tian‐Hua Wei, Shuangshuang Zhou, Xiaolong Jing, Jia‐Chuan Liu, Meng Sun, Zong-Hao Zhao, Qingqing Li, Zixuan Wang, Jin Yang, Yun Zhou, Xue Wang, Cheng-Xiao Ling, Ning Ding, Xin Xue, Yan‐Cheng Yu, Xiao-Long Wang, Xiaoying Yin, Shan‐Liang Sun, Peng Cao, Nian‐Guang Li, Zhi‐Hao Shi

Journal of Chemical Information and Modeling

DOI

2024

Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation**

Qing-Xin Wang, Jiao Cai, Zi‐Jun Chen, Jia‐Chuan Liu, Jing‐Jing Wang, Hai Zhou, Qing‐Qing Li, Zixuan Wang, Yi‐Bo Wang, Zhen‐Jiang Tong, Jin Yang, Tian‐Hua Wei, Meng‐Yuan Zhang, Yun Zhou, Wei‐Chen Dai, Ning Ding, Xuejiao Leng, Xiaoying Yin, Shan‐Liang Sun, Yan‐Cheng Yu, Nian‐Guang Li, Zhi‐Hao Shi

Molecular Informatics

DOI

2023

物理化学全英文课程教学实践

赵家昌，郑文锐，芮一川，瞿祎，刘凤娇，尹小英

《上海化工》

2023

Synthesis and neuroprotective activity of a (–)-cytisine-isoflavone conjugate

Li Tang, Ling-Yan Chen, Z. Jia, Hao Zheng, Zhang-Rui Li, Xiaoying Yin

Chemistry of Heterocyclic Compounds

DOI

2023

Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Shan‐Liang Sun, Jia‐Zhen Wu, Jingjing Wang, Hai Zhou, Chen-Qian Zhang, Zhen‐Jiang Tong, Yibo Wang, Jiu‐Kai Sha, Qing-Xin Wang, Jia‐Chuan Liu, Xin-Rui Zheng, Qingqing Li, Mengyuan Zhang, Jin Yang, Tian‐Hua Wei, Zixuan Wang, Yan‐Cheng Yu, Ning Ding, Xuejiao Leng, Xin Xue, LI He-min, Wei‐Chen Dai, Xiaoying Yin, Ye Yang, Jin‐Ao Duan, Nian‐Guang Li, Zhi‐Hao Shi

Biomedicine & Pharmacotherapy

DOI

2022

Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L.

Chen-Xu Meng, Yanqing Wang, Shen-Tan Chen, Min Li, Chun-Ping Yuan, Xiaoying Yin

Bioorganic & Medicinal Chemistry

DOI

2022

The Facile Preparation of PBA-GO-CuO-Modified Electrochemical Biosensor Used for the Measurement of α-Amylase Inhibitors’ Activity

Min Li, Xiaoying Yin, Hongli Shan, Chen Meng, Sheng Chen, Yinan Yan

Molecules

DOI

2022

Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors.

Yanqing Wang, Xiaoying Yin, Ling-Yan Chen, Zhixian Yin, Z. Zuo

Bioorganic chemistry (Print)

DOI

2022

Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation.

Ying Wang, Ting-Dong Hu, Jingjing Wei, Xiaoying Yin, Zhong-Hong Gao, Hai-Ling Li

International Journal of Biological Macromolecules

DOI

2022

New Dimeric Cytisine-Type Alkaloid and Lavandulyl Biflavonoid from Sophora flavescens AIT. and Their Inhibitory Effect on Cancer Cells

Xiaoying Yin, Sheng Chen, Yan Liu, Chen Meng, Min Li, Chun-Ping Yuan

Heterocycles

DOI

2021

Preparation and evaluation of photo-responsive hollow SnO2 molecularly imprinted polymers for the selective recognition of kaempferol.

Yun Sun, Xiaoying Yin, Lin Zhang, Menghui Cao

Analytical Methods

DOI

2021

Rapid screening of active components group with Topoisomerase I inhibitory activity in Sophora alopecuroides L. based on ultrafiltration coupled with UPLC-QTOF-MS.

Lin Zhang, Xiaoying Yin, Xi Wan, Yun Sun, Menghui Cao, Sheng Ouyang

Current Pharmaceutical Biotechnology

DOI

2021

Novel high-quantum-yield polydiacetylene conjugated AIE micelles for amplified fluorescence signaling and photodynamic therapy

Menghui Cao, Xiaoying Yin, Xin Luo, Yi Qu, Lin Zhang, Yun Sun, Yi-Nan Yan

DOI

2020

Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology

Si Sheng, Xiaoying Yin, Fangmei Chen, Yixin Lv, Lin Zhang, Menghui Cao, Yun Sun

AAPS PharmSciTech

DOI

2020

Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation.

Fangmei Chen, Xiaoying Yin, Yanqing Wang, Yixin Lv, Si Sheng, Sheng Ouyang, You-Quan Zhong

Biological and Pharmaceutical Bulletin

DOI

2020

Structure relationship of metalloporphyrins in inhibiting the aggregation of hIAPP.

Jin-Ming Wu, Xiaoying Yin, Huixian Ye, Zhong-Hong Gao, Hai-Ling Li

International Journal of Biological Macromolecules

DOI

2019

槐属植物生物碱研究进展

万喜，刘伟婷，尹小英

《亚太传统医药》

2018

肿瘤标志物PHPAA分子印迹聚合物的合成与性能研究

刘伟婷，张媛媛，乾康，高淑婷，万喜，尹小英

《中国药房》

2018

乳液聚合法制备PMMA/CS壳核纳微球的研究

高淑婷，张媛媛，乾康，万喜，刘伟婷，尹小英

《江西中医药》

2017

高效液相色谱法测定不同产地藏药诃子中7种鞣质类有效成分的含量

张媛媛，乾康，高淑婷，刘伟婷，尹小英

《中国药学杂志》

2017

Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture.

Qing-Shan Liu, Ran Deng, Qing-Fang Yan, Lin Cheng, Yong-Ming Luo, Ke-Qin Li, Xiaoying Yin, Xiaoyan Qin

ACS Applied Materials and Interfaces

DOI

2017

Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

Kang Qian, Han Wang, Jieming Liu, Shuting Gao, Weiting Liu, Xi Wan, Yuanyuan Zhang, Qingshan Liu, Xiaoying Yin

New Journal of Chemistry

DOI

2017

Research on the neuro-protective compounds in Terminalia chebula retz extracts in-vivo by UPLC–QTOF-MS

Yuanyuan Zhang, Xiaohui Liu, Shuting Gao, Kang Qian, Qingshan Liu, Xiaoying Yin

Acta Chromatographica

DOI

2016

正交试验优选诃子中总鞣质提取工艺研究

张媛媛，刘福雷，乾康，高舒婷，尹小英

《江西中医药》

2016

藏药诃子提取物HZ4对脑梗死模型的神经保护作用及分子机制研究

刘庆山，张伟伟，尹小英，李旭

《中国中药杂志》

2016

Innovative method for the enrichment of high‐polarity bioactive molecules present at low concentrations in complex matrices

Qingshan Liu, Jie He, Wen‐Bin Zhou, Yu‐Long Gu, Huoqiang Huang, Keqin Li, Xiaoying Yin

Journal of Separation Science

DOI

2015

拉曼光谱技术及其在药物研究中的应用

任小丹，罗香，冯会，衷友泉，尹小英

《中国新药杂志》

2015

中药苦豆子生物碱的研究进展

游菁菁，李月英，沙碧莹，尹小英

《江西中医药大学学报》

2015

天然抗肿瘤活性成分靶向筛选和分离方法研究进展

冯会，任小丹，尹小英

《江西中医药大学学报》

2015

α-葡萄糖苷酶纳米粒的制备及其性质研究

陈婵娟，尹小英，沙碧莹，衷友泉

《江西中医药》

2014

高效液相色谱法测定不同产地苦豆子各部位中6种生物碱

游菁菁，沙碧莹，尹小英

《中国药学杂志》

2014

丝穗金粟兰化学成分分离

马兴霞，罗刚，尹小英

《时珍国医国药》

2013

2种聚合方法制备人参皂苷Rg1分子印迹聚合物分离材料的比较研究

刘庆山，衣丽娜，李克琴，尹小英

《中国中药杂志》

2013

多穗金粟兰粗提物提取方法的比较

罗杠，马兴霞，尹小英

《江西中医药大学学报》

2012

分子印迹聚合物定向分离分析药材中白术内酯Ⅲ的研究

江一帆，李进进，衷友泉，罗刚，马兴霞，尹小英

《中国药学杂志》

2012

高通量技术与网络药理学在中药活性成分筛选中的应用

刘庆山，张梓倩，方亮，江一帆，尹小英

《中国中药杂志》

2012

HPLC测定樟木中黄樟醚二醇的含量

尹小英，罗永东，金镭，徐发红，罗永明

《中国实验方剂学杂志》

2012

短梗大参的化学成分研究

罗永明，刘华，尹小英，叶喜德，康丽洁

《中国中药杂志》

2012

分子印迹技术高效分离中药活性成分的应用

衣丽娜，尹小英，江一帆，刘庆山

《国际药学研究杂志》

2011

反相高效液相色潽法同时检测逍遥丸中芍药苷、阿魏酸和槲皮素的含量

苏兰宜，尹小英

《中国医院药学杂志》

2011

罗布麻定时脉冲片中5种酚酸及黄酮类成分的含量测定

尹小英，江一帆，杨华生，付剑江，刘红宁，罗永明

《中国药学杂志》

2011

罗布麻叶提取物对离体大鼠胸主动脉环的舒张作用

付剑江，吕红，杨华生，尹小英，郑洋滨，罗永明

《中国实验方剂学杂志》

2010

中药葛根指纹图谱不同梯度洗脱模式分离条件的优化

尹小英，罗永明，胡育筑

《药物分析杂志》

2010

分子印迹聚合反应中功能单体与模板分子间作用力的光谱分析

尹小英，衷友泉，江一帆，罗永明

《光谱学与光谱分析》

2009

药用植物樟的研究概况

尹小英，李石蓉，李琴，罗永明

《江西中医药大学学报》

2008

反相高效液相色谱法测定沙利度胺的有关物质

欧贝丽，尹小英，徐菊芳，胡育筑

《中国药学杂志》

2008

柱温和流速对反相离子对色谱法分析寡核苷酸的影响

骆雪芳，尹小英，付静静，胡育筑

《分析化学》

2008

Optimization of gradient separation for chromatographic fingerprint of herbal medicine: a predictive model combined with grid search.

Xiaoying Yin, Weifeng Yao, Yu-Zhu Hu

Journal of Chromatographic Science

DOI

2007

中药指纹图谱的线性梯度分离条件的快速优化方法

尹小英，姚卫峰，胡育筑

《分析化学》

2007

溶质线性梯度保留时间的多元回归预测模型

尹小英，姚卫峰，胡育筑

《中国药科大学学报》

2007

A new algorithm of piecewise automated beam search for peak alignment of chromatographic fingerprints.

Weifeng Yao, Xiaoying Yin, Yu-Zhu Hu

Journal of Chromatography A

DOI

2005

应用PCA-ANN技术研究中药厚朴色谱指纹谱与抗氧化活性的关系

冯慧萍，杨中林，尹小英，姚卫峰，胡育筑

Chinese Journal of Natural Medicines

2004

固相萃取-高效液相色谱法测定肾宝合剂中淫羊藿苷的含量

干剑钦，尹小英

《江西中医药大学学报》

2002

中药指纹图谱的研究进展

宋国跃，尹小英，罗永明

《江西中医药》

2001

高效液相色谱法测定山茱萸中熊果酸的含量

尹小英，欧阳栋

《江西中医药大学学报》

精选作品

期刊论文

基于知识图谱的药物分析课程构建研究

A derivative of cytisine N-isoflavone from Sophora alopecuroides L., suppresses non-small cell lung cancer by targeting mTOR.

A scalable and cost-effective 3D tumor spheroid array chip for distortion-free optical monitoring and drug screening

Computational and Experimental Analysis of Sophora alopecuroides L. Chloroform Fraction: Active Components and Anti-Breast Cancer Resistance Mechanisms

From reaction energetics to automated analysis tool auxiliary identification: A self-validating multidimensional liquid chromatography- mass spectrometry framework for characterizing polymerized impurities in carbapenem antibiotics.

Molecular Mechanisms of Reversal of Multidrug Resistance in Breast Cancer by Inhibition of P-gp by Cytisine N-Isoflavones Derivatives Explored Through Network Pharmacology, Molecular Docking, and Molecular Dynamics

Development and validation of a sensitive liquid chromatography-tandem mass spectrometry method for the assay of 12 substances in rat plasma and its application to rat pharmacokinetics of Epimedium and Psoraleae Fructus herb pair after oral administration.

Kinase-Bench: Comprehensive Benchmarking Tools and Guidance for Achieving Selectivity in Kinase Drug Discovery

Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation**

物理化学全英文课程教学实践

Synthesis and neuroprotective activity of a (–)-cytisine-isoflavone conjugate

Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Discovery, Topo I inhibitory activity and mechanism evaluation of two novel cytisine-type alkaloid dimers from the seeds of Sophora alopecuroides L.

The Facile Preparation of PBA-GO-CuO-Modified Electrochemical Biosensor Used for the Measurement of α-Amylase Inhibitors’ Activity

Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors.

Inhibitory activities of flavonoids from Scutellaria baicalensis Georgi on amyloid aggregation related to type 2 diabetes and the possible structural requirements for polyphenol in inhibiting the nucleation phase of hIAPP aggregation.

New Dimeric Cytisine-Type Alkaloid and Lavandulyl Biflavonoid from Sophora flavescens AIT. and Their Inhibitory Effect on Cancer Cells

Preparation and evaluation of photo-responsive hollow SnO2 molecularly imprinted polymers for the selective recognition of kaempferol.

Rapid screening of active components group with Topoisomerase I inhibitory activity in Sophora alopecuroides L. based on ultrafiltration coupled with UPLC-QTOF-MS.

Novel high-quantum-yield polydiacetylene conjugated AIE micelles for amplified fluorescence signaling and photodynamic therapy

Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology

Pharmacokinetics, Tissue Distribution, and Druggability Prediction of the Natural Anticancer Active Compound Cytisine N-Isoflavones Combined with Computer Simulation.

Structure relationship of metalloporphyrins in inhibiting the aggregation of hIAPP.

槐属植物生物碱研究进展

肿瘤标志物PHPAA分子印迹聚合物的合成与性能研究

乳液聚合法制备PMMA/CS壳核纳微球的研究

高效液相色谱法测定不同产地藏药诃子中7种鞣质类有效成分的含量

Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture.

Synthesis of α-glycosidase hybrid nano-flowers and their application for enriching and screening α-glycosidase inhibitors

Research on the neuro-protective compounds in Terminalia chebula retz extracts in-vivo by UPLC–QTOF-MS

正交试验优选诃子中总鞣质提取工艺研究

藏药诃子提取物HZ4对脑梗死模型的神经保护作用及分子机制研究

Innovative method for the enrichment of high‐polarity bioactive molecules present at low concentrations in complex matrices

拉曼光谱技术及其在药物研究中的应用

中药苦豆子生物碱的研究进展

天然抗肿瘤活性成分靶向筛选和分离方法研究进展

α-葡萄糖苷酶纳米粒的制备及其性质研究

高效液相色谱法测定不同产地苦豆子各部位中6种生物碱

丝穗金粟兰化学成分分离

2种聚合方法制备人参皂苷Rg1分子印迹聚合物分离材料的比较研究

多穗金粟兰粗提物提取方法的比较

分子印迹聚合物定向分离分析药材中白术内酯Ⅲ的研究

高通量技术与网络药理学在中药活性成分筛选中的应用

HPLC测定樟木中黄樟醚二醇的含量

短梗大参的化学成分研究

分子印迹技术高效分离中药活性成分的应用

反相高效液相色潽法同时检测逍遥丸中芍药苷、阿魏酸和槲皮素的含量

罗布麻定时脉冲片中5种酚酸及黄酮类成分的含量测定

罗布麻叶提取物对离体大鼠胸主动脉环的舒张作用

中药葛根指纹图谱不同梯度洗脱模式分离条件的优化

分子印迹聚合反应中功能单体与模板分子间作用力的光谱分析

药用植物樟的研究概况

反相高效液相色谱法测定沙利度胺的有关物质

柱温和流速对反相离子对色谱法分析寡核苷酸的影响

Optimization of gradient separation for chromatographic fingerprint of herbal medicine: a predictive model combined with grid search.

中药指纹图谱的线性梯度分离条件的快速优化方法

溶质线性梯度保留时间的多元回归预测模型

A new algorithm of piecewise automated beam search for peak alignment of chromatographic fingerprints.

应用PCA-ANN技术研究中药厚朴色谱指纹谱与抗氧化活性的关系

固相萃取-高效液相色谱法测定肾宝合剂中淫羊藿苷的含量

中药指纹图谱的研究进展

高效液相色谱法测定山茱萸中熊果酸的含量

会议论文

Preparation of Immobilized Recombinant Tubulin Beta(TuBb) on Chitosan Nanoparticles by Covalent Binding Method

槲皮素分子印迹聚合物微球分离不同药材中降压活性成分的研究(摘要)

金粟兰科植物的化学成分研究

研究方向