郑书国｜皖南医学院｜学者主页

2026

丹酚酸B通过调节PPARγ/NLRP3通路改善2型糖尿病小鼠胰岛功能

赵梦秋，宣佳利，郑书国

《齐齐哈尔医学院学报》

2025

Curcumol ameliorates high-fat diet-induced hepatic fibrosis via dual regulation of FXR-CREB and Rab18-mediated hepatic stellate cell lipophagy

Na Wei, Wanyu Feng, Meijun Pan, Xinyi Xu, Shuguo Zheng, Huanhuan Jin

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI

2025

Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

Yongsheng Shu, Wanqing Shen, Wanyu Feng, Meijun Pan, Xinyi Xu, Shuguo Zheng, Huanhuan Jin

Biomolecules

DOI

2025

dHG-5 Exhibits Dual Efficacy of Anti-Metastatic and Anti-hypercoagulability in Mice by Inhibiting Heparanase and Intrinsic Coagulation Pathway

Ziheng Tong, Zhipeng Xu, Wen Yang, H.-R. Song, Shuguo Zheng, Lutan Zhou

Anti-Cancer Agents in Medicinal Chemistry

DOI

2024

Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway

Tingting Ding, Wanqing Shen, Wenhui Tao, Junlu Peng, Meijun Pan, Xiaoyu Qi, Wanyu Feng, Na Wei, Shuguo Zheng, Huanhuan Jin

The Journal of Nutritional Biochemistry

DOI

2023

Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

Mingyue Ma, Na Wei, Yang Jie-ren, Tingting Ding, Anping Song, Lerong Chen, Shuguo Zheng, Huanhuan Jin

Pharmaceutical Biology

DOI

2023

Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity

Anping Song, Tingting Ding, Na Wei, Yang Jie-ren, Mingyue Ma, Shuguo Zheng, Huanhuan Jin

Toxicology and Applied Pharmacology

DOI

2022

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease

Xiaoyu Qi, Shuguo Zheng, Shuguo Zheng, Mingyue Ma, Naqi Lian, Hongting Wang, Lerong Chen, Anping Song, Chunfeng Lu, Shizhong Zheng, Shizhong Zheng, Huanhuan Jin

Frontiers in Pharmacology

DOI

2021

丹酚酸B改善糖尿病血糖波动模型大鼠心肌损伤的作用

赵梦秋，任尤楠，陶善珺，郑书国

《山东第一医科大学(山东省医学科学院)学报》

2021

丹酚酸B抑制波动高糖诱导的糖尿病大鼠心肌细胞凋亡

赵梦秋，任尤楠，陶善珺，郑书国

《中成药》

2021

芝麻素和维生素E通过调节内皮型一氧化氮合酶和NAD(P)H氧化酶4改善D-半乳糖和三氯化铝诱导的大鼠主动脉内皮功能障碍（英文）

张俊秀，姚海，王欢，杨解人，郑书国

《中国药理学与毒理学杂志》

2021

四君子颗粒抑制棕榈酸诱导的STC-1细胞凋亡

袁萍，张旭，唐保露，戚小宇，马明悦，郑书国

《山东第一医科大学(山东省医学科学院)学报》

2021

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non‐alcoholic fatty liver disease

Xiaoyu Qi, Anping Song, Mingyue Ma, Peipei Wang, Xinbei Zhang, Chunfeng Lu, Junxiu Zhang, Shuguo Zheng, Huanhuan Jin

Cell Proliferation

DOI

2021

LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

Ping Yuan, Xiaoyu Qi, Anping Song, Mingyue Ma, Xinbei Zhang, Lu Chunfeng, Mianli Bian, Naqi Lian, Jianling He, Shuguo Zheng, Huanhuan Jin

Journal of Cellular and Molecular Medicine

DOI

2020

四君子颗粒对大鼠糖尿病前期的改善作用

唐保露，张旭，袁萍，朱元美，杨解人，郑书国

《中成药》

2020

联用芝麻素和维生素E抑制PI3K/AKT信号通路改善自发性高血压大鼠的左室纤维化（英文）

张俊秀，沈媛媛，杨解人，郑书国，郝伟

《中国临床药理学与治疗学》

2020

四君子颗粒含药血清对棕榈酸诱导的MIN6细胞凋亡的影响

唐保露，郑宇辰，张叶明，袁萍，戚小宇，张旭，杨解人，郑书国

《中成药》

2019

丹酚酸B对高糖诱导的肾小球系膜细胞表型转化及细胞外基质分泌的影响

朱元美，尹步金，张旭，唐保露，程宇鹏，杨解人，郑书国

《中国病理生理杂志》

2019

丹酚酸B对糖尿病大鼠肾纤维化的改善作用及其机制

张旭，朱元美，唐保露，任尤楠，陶善珺，杨解人，郑书国

《中国药理学通报》

2018

丹酚酸B对糖尿病大鼠血管舒张功能、NF-κB活化及炎症因子表达的影响

Meng-Qiu Zhao, You-Nan Ren, Shan-Jun Tao, Yuan-Jie Wu, Shuguo Zheng, Yong Hong

DOI

2017

丹酚酸B对间歇性高糖诱导的JNK活化和INS-1细胞凋亡的影响

郑书国，朱元美，陶善珺，郑浩文，任尤楠，赵梦秋，杨解人，吴元洁

《中国药理学通报》

2017

Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential

Tao Shanjun, Ren Younan, Haowen Zheng, Mengqiu Zhao, Xu Zhang, Zhu Yuanmei, Yang Jie-ren, Shuguo Zheng

European Journal of Pharmacology

DOI

2016

丹酚酸B对糖尿病血糖波动模型大鼠胰岛细胞的保护作用

陶善珺，任尤楠，赵梦秋，郑书国，朱元美，吴元洁

《中草药》

2016

芝麻素预处理激活Akt/eNOS通路减轻大鼠心肌缺血-再灌注损伤

赵梦秋，涂鹏程，任尤楠，陶善珺，郑书国

《中药材》

DOI

2016

丹酚酸B对波动高糖诱导人脐静脉内皮细胞凋亡的影响

任尤楠，陶善珺，赵梦秋，郑书国，朱元美，杨解人，吴元洁

《中药材》

DOI

2016

Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis

Ren Younan, Tao Shanjun, Shuguo Zheng, Mengqiu Zhao, Zhu Yuanmei, Yang Jie-ren, Yuanjie Wu

European Journal of Pharmacology

DOI

2016

サルビアノール酸Bは糖尿病性血糖変動モデルラットの膵島細胞に対する保護作用【JST・京大機械翻訳】

Shan-Jun Tao, You-Nan Ren, Meng-Qiu Zhao, Shuguo Zheng, Yuan-Mei Zhu, Yuan-Jie Wu

2016

Effect of Salvianolic Acid B on HUVECs Apoptosis Induced by Intermittent High Glucose

You-Nan Ren, Shan-Jun Tao, Meng-Qiu Zhao, Shuguo Zheng, Yuan-Mei Zhu, Jie-ren Yang, Yuan-Jie Wu

2016

サルビアノール酸Bによるヒト臍帯静脈内皮細胞のアポトーシスへの影響を検討した。【JST・京大機械翻訳】

You-Nan Ren, Shan-Jun Tao, Meng-Qiu Zhao, Shuguo Zheng, Yuan-Mei Zhu, Jie-ren Yang, Yuan-Jie Wu

2015

丹蛭降糖胶囊对糖尿病血糖波动模型大鼠心肌纤维化的影响

郑书国，陶善珺，赵梦秋，任尤楠，吴元洁

《中药材》

DOI

2015

芝麻素对大鼠心肌缺血再灌损伤的保护作用

涂鹏程，郑书国，杨解人，任尤楠，陶善珺，赵梦秋，曹雨朦，许梦情，李方圆

《皖南医学院学报》

2015

芝麻素对AngⅡ诱导的心肌成纤维细胞增殖和胶原分泌的影响

曹雨朦，郑书国，赵梦秋，任尤楠，涂鹏程，李方圆，陈雪祎，常雪允

《皖南医学院学报》

2015

番红花酸对人脐静脉内皮细胞VCAM-1表达和单核-内皮细胞黏附的影响

郑书国，赵梦秋，任尤楠，杨解人，钱之玉

《药学学报》

DOI

2015

芝麻素含药血清对血管紧张素Ⅱ诱导大鼠心肌细胞凋亡的影响

郑书国，任尤楠，赵梦秋，陶善珺，孔祥，杨解人

《中药材》

DOI

2015

丹蛭降糖胶囊对波动高糖诱导的INS-1细胞凋亡和胰岛素分泌的影响

郑书国，赵梦秋，吴元洁，任尤楠

《中成药》

2015

芝麻素含药血清对血管紧张素Ⅱ诱导的心肌成纤维细胞增殖和胶原分泌的影响

任尤楠，赵梦秋，郑书国，陶善珺，杨解人，孔祥

《广东医学》

2015

Suppression of pancreatic beta cell apoptosis by Danzhi Jiangtang capsule contributes to the attenuation of type 1 diabetes in rats

Shuguo Zheng, Mengqiu Zhao, Yuanjie Wu, Zheng Wang, Ren Younan

BMC Complementary and Alternative Medicine

DOI

2015

Suppression of TGF-β1/Smad Signaling Pathway by Sesamin Contributes to the Attenuation of Myocardial Fibrosis in Spontaneously Hypertensive Rats

Mengqiu Zhao, Shuguo Zheng, Yang Jie-ren, Yuanjie Wu, Ren Younan, Xiang Kong, Wei Li, Jiali Xuan

PLoS ONE

DOI

2015

Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression

Shuguo Zheng, Mengqiu Zhao, Ren Younan, Yuanjie Wu, Yang Jie-ren

European Journal of Pharmacology

DOI

2014

糖尿病大鼠血糖波动下SOD、MDA、NO变化及丹蛭降糖胶囊的干预作用

吴元洁，郑书国，方朝晖，吴元波，吴传云，王玉凤，刘晓丽，张晓军

《中成药》

2014

糖尿病大鼠血糖波动模型的建立

吴元洁，吴元波，郑书国，王玉凤，刘晓丽，张晓军，吕明安

《南方医科大学学报》

2014

[Experimental research on establishing a blood glucose fluctuation model in diabetic rats].

Yuan-Jie Wu, Yuan-Bo Wu, Shuguo Zheng, Yu-Feng Wang, Xiao-Li Liu, Xiao-Jun Zhang, Mingan Lv

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2013

丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺NADPH氧化酶亚单位p22phox表达水平的影响

吴元洁，方朝晖，郑书国，吴元波，王正，吕明安

《中国中西医结合杂志》

2012

丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺JNK信号通路的影响

吴元洁，方朝晖，郑书国，吴元波，范爱华

Journal of Integrative Medicine

2012

番茄红素对低密度脂蛋白氧化的影响

朋汤义，郑书国

《中国医药科学》

2009

Effects of Crocetin on the Susceptibility of LDL to Oxidation and Serum Level of Ox-LDL in Hyperlipidemic Rabbits

Shuguo Zheng

2007

Crocetin Suppresses Angiotensin II-Induced Vascular Smooth-Muscle Cell Proliferation Through Inhibition of ERK1/2 Activation and Cell-Cycle Progression

Shuguo Zheng, Zhiyu Qian, Na Wen, Xi Liang

Journal of Cardiovascular Pharmacology

DOI

2007

Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats.

L. Xi, Zhi-Yu Qian, Guang-Lin Xu, Shuguo Zheng, Sai Sun, Na Wen, Liang Sheng, Yunrong Shi, Yabing Zhang

Journal of Nutritional Biochemistry

DOI

2006

Crocetin Attenuates Atherosclerosis in Hyperlipidemic Rabbits Through Inhibition of LDL Oxidation

Shuguo Zheng, Zhi-Yu Qian, Liang Sheng, Na Wen

Journal of Cardiovascular Pharmacology

DOI

2006

Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity.

Fu-Tian Tang, Zhi-Yu Qian, Peiqing Liu, Shuguo Zheng, S.-Y. He, Liping Bao, Hong-Zhang Huang

Biochemical Pharmacology

DOI

2006

Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase.

Liang Sheng, Zhi-Yu Qian, Shuguo Zheng, L. Xi

European Journal of Pharmacology

DOI

2006

ERK1/2 pathway is involved in the inhibitory effect of crocetin on angiotensin II-induced vascular smooth muscle cell proliferation.

Cheng-Hua Zhou, Zhi-Yu Qian, Shuguo Zheng, Min Xiang

European Journal of Pharmacology

DOI

2005

Effe西红花酸对动脉粥样硬化鹌鹑血清一氧化氮含量的影响及其机制(英文)

唐富天，钱之玉，郑书国

Chinese Journal of Natural Medicines

2005

西红花酸对高血脂家兔血管舒张功能的影响及其机制

唐富天，钱之玉，郑书国

《中国动脉硬化杂志》

2005

Effects of Crocetin on Serum Nitric Oxide Content of Atherosclerotic Quail and Its Mechanism

Fu-Tian Tang, Zhi-Yu Qian, Shuguo Zheng

2005

Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits.

Shuguo Zheng, Zhi-Yu Qian, Fu-Tian Tang, Liang Sheng

Biochemical Pharmacology

DOI

精选作品

期刊论文

丹酚酸B通过调节PPARγ/NLRP3通路改善2型糖尿病小鼠胰岛功能

Curcumol ameliorates high-fat diet-induced hepatic fibrosis via dual regulation of FXR-CREB and Rab18-mediated hepatic stellate cell lipophagy

Targeting HMGCS2: Ketogenesis Suppression Accelerates NAFLD Progression in T2DM Comorbidity, While Cynaroside Ameliorates NASH in Concomitant T2DM

dHG-5 Exhibits Dual Efficacy of Anti-Metastatic and Anti-hypercoagulability in Mice by Inhibiting Heparanase and Intrinsic Coagulation Pathway

Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway

Schisandrin B promotes senescence of activated hepatic stellate cell via NCOA4-mediated ferritinophagy

Schisandrin B induces HepG2 cells pyroptosis by activating NK cells mediated anti-tumor immunity

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B–Lamin B1 Interaction in Alcoholic Fatty Liver Disease

丹酚酸B改善糖尿病血糖波动模型大鼠心肌损伤的作用

丹酚酸B抑制波动高糖诱导的糖尿病大鼠心肌细胞凋亡

芝麻素和维生素E通过调节内皮型一氧化氮合酶和NAD(P)H氧化酶4改善D-半乳糖和三氯化铝诱导的大鼠主动脉内皮功能障碍（英文）

四君子颗粒抑制棕榈酸诱导的STC-1细胞凋亡

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non‐alcoholic fatty liver disease

LncRNA MAYA promotes iron overload and hepatocyte senescence through inhibition of YAP in non‐alcoholic fatty liver disease

四君子颗粒对大鼠糖尿病前期的改善作用

联用芝麻素和维生素E抑制PI3K/AKT信号通路改善自发性高血压大鼠的左室纤维化（英文）

四君子颗粒含药血清对棕榈酸诱导的MIN6细胞凋亡的影响

丹酚酸B对高糖诱导的肾小球系膜细胞表型转化及细胞外基质分泌的影响

丹酚酸B对糖尿病大鼠肾纤维化的改善作用及其机制

丹酚酸B对糖尿病大鼠血管舒张功能、NF-κB活化及炎症因子表达的影响

丹酚酸B对间歇性高糖诱导的JNK活化和INS-1细胞凋亡的影响

Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential

丹酚酸B对糖尿病血糖波动模型大鼠胰岛细胞的保护作用

芝麻素预处理激活Akt/eNOS通路减轻大鼠心肌缺血-再灌注损伤

丹酚酸B对波动高糖诱导人脐静脉内皮细胞凋亡的影响

Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis

サルビアノール酸Bは糖尿病性血糖変動モデルラットの膵島細胞に対する保護作用【JST・京大機械翻訳】

Effect of Salvianolic Acid B on HUVECs Apoptosis Induced by Intermittent High Glucose

サルビアノール酸Bによるヒト臍帯静脈内皮細胞のアポトーシスへの影響を検討した。【JST・京大機械翻訳】

丹蛭降糖胶囊对糖尿病血糖波动模型大鼠心肌纤维化的影响

芝麻素对大鼠心肌缺血再灌损伤的保护作用

芝麻素对AngⅡ诱导的心肌成纤维细胞增殖和胶原分泌的影响

番红花酸对人脐静脉内皮细胞VCAM-1表达和单核-内皮细胞黏附的影响

芝麻素含药血清对血管紧张素Ⅱ诱导大鼠心肌细胞凋亡的影响

丹蛭降糖胶囊对波动高糖诱导的INS-1细胞凋亡和胰岛素分泌的影响

芝麻素含药血清对血管紧张素Ⅱ诱导的心肌成纤维细胞增殖和胶原分泌的影响

Suppression of pancreatic beta cell apoptosis by Danzhi Jiangtang capsule contributes to the attenuation of type 1 diabetes in rats

Suppression of TGF-β1/Smad Signaling Pathway by Sesamin Contributes to the Attenuation of Myocardial Fibrosis in Spontaneously Hypertensive Rats

Sesamin suppresses STZ induced INS-1 cell apoptosis through inhibition of NF-κB activation and regulation of Bcl-2 family protein expression

糖尿病大鼠血糖波动下SOD、MDA、NO变化及丹蛭降糖胶囊的干预作用

糖尿病大鼠血糖波动模型的建立

[Experimental research on establishing a blood glucose fluctuation model in diabetic rats].

丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺NADPH氧化酶亚单位p22phox表达水平的影响

丹蛭降糖胶囊联合运动对糖尿病大鼠胰腺JNK信号通路的影响

番茄红素对低密度脂蛋白氧化的影响

Effects of Crocetin on the Susceptibility of LDL to Oxidation and Serum Level of Ox-LDL in Hyperlipidemic Rabbits

Crocetin Suppresses Angiotensin II-Induced Vascular Smooth-Muscle Cell Proliferation Through Inhibition of ERK1/2 Activation and Cell-Cycle Progression

Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats.

Crocetin Attenuates Atherosclerosis in Hyperlipidemic Rabbits Through Inhibition of LDL Oxidation

Crocetin improves endothelium-dependent relaxation of thoracic aorta in hypercholesterolemic rabbit by increasing eNOS activity.

Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase.

ERK1/2 pathway is involved in the inhibitory effect of crocetin on angiotensin II-induced vascular smooth muscle cell proliferation.

Effe西红花酸对动脉粥样硬化鹌鹑血清一氧化氮含量的影响及其机制(英文)

西红花酸对高血脂家兔血管舒张功能的影响及其机制

Effects of Crocetin on Serum Nitric Oxide Content of Atherosclerotic Quail and Its Mechanism

Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits.

研究方向