鞠佃文｜复旦大学｜学者主页

2026

A potent anti-CD47 antibody decoupling anti-tumor efficacy from hematotoxicity

Mingxia He, Yaoyao Zhao, Jiujiu Cao, Zhongdao Li, Lihao Wang, Siyuan Hou, Qiangjian Zhang, Liang Sun, Yuqi Zhao, Tianyu Chen, Zhigang Guo, Dianwen Ju

International Immunopharmacology

DOI

2026

Anti-ANGPTL3 antibody and IL-22 fusion protein mitigate nephrotic syndrome via mitochondrial protection, anti-apoptosis, and autophagy suppression

Qianqian Ma, Leilin Shao, Guangjun Jing, Fangyu Liu, Kaicheng Zhou, Fujie Wen, Haidong He, Dianwen Ju, Jialu Liu

Antibody Therapeutics

DOI

2026

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju

Advanced Science

DOI

2026

Integrative Transcriptomic Analysis Identifies COL3A1 as a Potential Tumor-Intrinsic Therapeutic Target in NSCLC

Kaicheng Zhou, Yanyang Nan, M C Li, Dongyue Hou, C Xu, Haiyan Yu, Jun Feng, Dianwen Ju, Ziyu Wang

Biomedicines

DOI

2026

Targeting angiopoietin-like protein 3 and interleukin-1β alleviated liver and kidney injury through attenuation of lipotoxicity and regulation of glycolipid metabolism in db/db mice

Shuwen Xu, Longfei Wang, Zihan Dou, Xiaozhi Hu, Zhonglian Cao, Yuanzhen Zhang, Xianhan Jiang, Tao Wu, Zhuojin Li, Yanyang Nan, An Zhu, Yu Bai, Ziqian Zou, Xuyao Zhang, Xian Zeng, Haidong He, Shaofei Wang, Dianwen Ju, Jiajun Fan

Inflammation Research

DOI

2026

EGFR-targeted therapies based on antibody engineering and nanotechnology for colorectal cancer

Xingxing Shang, Ziyi Zhang, Tao Wu, Yanyang Nan, Dianwen Ju

Biomaterials

DOI

2025

Rubicon siRNA-encapsulated liver-targeting nanoliposome is a promising therapeutic for non-alcoholic fatty liver disease

Yuting Zhang, Hanqi Wang, Caili Xu, Xiaomiao Ye, Yanyang Nan, Xiaozhi Hu, Jiajun Fan, Xuebin Wang, Dianwen Ju

International Journal of Pharmaceutics

DOI

2025

A Dual CRISPR-Cas/Cre- loxP Genome Engineering Strategy for Stable Uricase Expression in Food-Grade Probiotics

Xi Tang, Dianwen Ju, Haifeng Hu

ACS Synthetic Biology

DOI

2025

MASI2.0: Insights of Microbiota Metabolic Potential from Incorporating Genomic Information on Microbiota-Active Substance Interactions

Dongyue Hou, Yuchen Liu, Hanbo Lin, Jiajie Gu, Juncheng Qian, Shaofei Wang, Yuzong Chen, Dianwen Ju, Xian Zeng

Journal of Molecular Biology

DOI

2025

MiRNA-based drugs: challenges and delivery strategies

Ziyu Wang, Yingyuan Peng, Haifeng Zhou, Min Zhang, Dianwen Ju, Zhilong Chen

Applied Microbiology and Biotechnology

DOI

2025

NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research

Hanbo Lin, Dongyue Hou, Xianhan Jiang, Ruining Yin, S Yu, Songlin Lu, Shanshan Wang, Dianwen Ju, Hui Zhao, Yu Chen, Xian Liang Zeng

Nucleic Acids Research

DOI

2025

ANGPTL3 nanobody-FGF21 fusion protein ameliorates metabolic dysfunction-associated fatty liver disease via regulation of lipid and glucose metabolism and attenuation of oxidative stress

Yuanzhen Zhang, Xiaozhi Hu, Zhonglian Cao, Kaicheng Zhou, Yun Sun, Yong Deng, Shuwen Xu, Yanyang Nan, Xi Gai, Mengyang Li, Yu Bai, M. Ge, Dianwen Ju

International Journal of Biological Macromolecules

DOI

2025

Improved biodistribution and antitumor effects of a Nectin4 and Trop2 bispecific fatty acid-modified nanobody conjugate

Guangjun Jing, Jiajun Fan, Xuyao Zhang, Xian Zeng, Zheng Song, Weihong Ding, Dianwen Ju

Journal of Controlled Release

DOI

2025

Enhanced Generalizability of RNA Secondary Structure Prediction via Convolutional Block Attention Network and Ensemble Learning

Hanbo Lin, Dongyue Hou, Zhihan Li, Shuaiqi Wang, Yuchen Liu, Jiajie Gu, Juncheng Qian, Ruining Yin, Hui Zhao, Shaofei Wang, Yu Chen, Dianwen Ju, Xian Liang Zeng

Molecules

DOI

2025

TargetPair: A Single Cell-omics Resource of Clinical Trials-derived Therapeutical Target Combinations for Cancer Therapy

Kaicheng Zhou, Xingxiu Li, Yuan Yang, Dongyue Hou, Shuaiqi Wang, Shuaiqi Wang, Hanbo Lin, Ruining Yin, Dianwen Ju, Xian Liang Zeng, Shaofei Wang, Shaofei Wang

Journal of Molecular Biology

DOI

2025

DDR1 Drives Collagen Remodeling and Immune Exclusion: Pan-Cancer Insights and Therapeutic Targeting in Pancreatic Ductal Adenocarcinoma

Xuan Huang, Guangjun Jing, Kudelaidi Kuerban, Jiajun Fan, Mei Yu, Shanglin Yang, Wei Chen, Litao Huang, Dianwen Ju, Yi Zhun Zhu, Li Ye

International Journal of Molecular Sciences

DOI

2025

Nanobody-engineered bispecific IL-18 mimetics drive antitumor immunity by engaging CD8+ T cell and evading IL-18BP in preclinical models

Yanyang Nan, Min Zhu, Qian Wang, Xiaoxue Du, Caili Xu, Yuping Huang, Yujie Liu, Shaoyuan Zhou, Yuluoyan Qiu, Xiao Chu, Dianwen Ju, Yakun Wan, Xuyao Zhang

Molecular Therapy

DOI

2025

Chemical Structure-based Graph Convolutional Model for Drug-Gut Microbiota Association Prediction

Shuaiqi Wang, Xingxiu Li, Kaicheng Zhou, Jianxi Li, Dongyue Hou, Caili Xu, Yuan Yang, Dianwen Ju, Xian Liang Zeng

Chemical Research in Chinese Universities

DOI

2025

A Hyperbolic Discrete Diffusion 3D RNA Inverse Folding Model for Functional RNA Design

Dongyue Hou, Shuai Zhang, Mengyao Ma, Hanbo Lin, Zheng Wan, Huijun Zhao, Ruian Zhou, Xiao Dong He, Xian Wei, Dianwen Ju, Xian Liang Zeng

Journal of Chemical Information and Modeling

DOI

2025

Rational Design of Site-Specific Fatty Acid Derivatives to Extend the Half-Life of Fibroblast Growth Factor 21

Chengcheng Wang, Yapeng Wang, Yuanzhen Dong, Yu Duan, Ying Zhang, Hao Huang, Zhiru Xu, Jianguang Lu, Chunyong Ding, Zhengyan Cai, Dianwen Ju, Jun Feng

Bioconjugate Chemistry

DOI

2025

Enhancing catalytic efficiency of two microbial uricases making by directed evolution

Xiaoyuan Tang, Liling Qin, Yuze Xia, Dianwen Ju, Haifeng Hu

International Journal of Biological Macromolecules

DOI

2025

IL-2-loaded liposomes modified with sorafenib derivative exert a synergistic anti-melanoma effect via improving tumor immune microenvironment and enhancing antiangiogenic activity

Xuan Huang, Kudelaidi Kuerban, J P Fan, Danjie Pan, Huaning Chen, Jiayang Liu, Songna Wang, Dianwen Ju, Yi Zhun Zhu, Jiyong Liu, Li Ye

Asian Journal of Pharmaceutical Sciences

DOI

2025

Development of an anti-LAIR1 antibody-drug conjugate for acute myeloid leukemia therapy

Weili Xu, Shuai Li, Kia Joo Puan, Xueting Li, Caili Xu, Jiajun Fan, Zihan Dou, Jiquan Zhang, Dianwen Ju

International Journal of Biological Macromolecules

DOI

2024

Lipid Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism

Yu Bai, Yanyang Nan, Tao Wu, An Zhu, Xinlei Xie, Yun Sun, Yong Deng, Zihan Dou, Xiaozhi Hu, Rongrui Zhou, Shuwen Xu, Yuanzhen Zhang, Jiajun Fan, Dianwen Ju

Advanced Science

DOI

2024

Prediction of human gut microbiota-drug associations based on multiple graph convolutional networks

Shuaiqi Wang, Xingxiu Li, Kaicheng Zhou, Jianxi Li, Dongyue Hou, Caili Xu, Yuan Yang, Dianwen Ju, Xian Liang Zeng

Bioinformatics Advances

DOI

2024

Lipidation-dimerization platform unlocks treatment potential of fibroblast growth factor 21 for non-alcoholic steatohepatitis

Yapeng Wang, Lei Shen, Chengcheng Wang, Yuanzhen Dong, Haoju Hua, Jun Xu, Ying Zhang, Hao Huang, Zongqing Huang, Fei Zhao, Zhiru Xu, Yunliang Qiu, Jianguang Lu, Dianwen Ju, Jun Feng

Journal of Controlled Release

DOI

2024

Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

Xiaozhi Hu, Yanyang Nan, Yuting Zhang, Jiajun Fan, Hanqi Wang, Yu Bai, Yuanzhen Zhang, Xuyao Zhang, Zeguo Zhu, Zhonglian Cao, Xiaomiao Ye, Tao Wu, Shuwen Xu, Zhengyu Wu, Wei Hu, Dianwen Ju

Pharmacological Research

DOI

2024

Natural killer cell engagers: From bi‐specific to tri‐specific and tetra‐specific engagers for enhanced cancer immunotherapy

An Zhu, Yu Bai, Yanyang Nan, Dianwen Ju

Clinical and Translational Medicine

DOI

2024

Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer

Caili Xu, Xiting Huang, Qinchao Hu, Wenjing Xue, Kaicheng Zhou, Xingxiu Li, Yanyang Nan, Dianwen Ju, Ziyu Wang, Xuyao Zhang

Biomedicine & Pharmacotherapy

DOI

2024

Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer

Xiting Huang, Qian Wang, Yanyang Nan, Xuyao Zhang, Ke Cheng XU, Dianwen Ju, Weihong Ding

Biomedicines

DOI

2024

Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation

Hanqi Wang, Xiaozhi Hu, Yuting Zhang, An Zhu, Jiajun Fan, Zhengyu Wu, Xuebin Wang, Wei Hu, Dianwen Ju

Inflammation Research

DOI

2024

Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer

Wenjing Xue, Caili Xu, Kaiqi Zhang, Lu Cui, Xiting Huang, Yanyang Nan, Dianwen Ju, Xusheng Chang, Xuyao Zhang

Cell Death Discovery

DOI

2024

Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy

Yanyang Nan, Yu Bai, Xiaozhi Hu, Kaicheng Zhou, Tao Wu, An Zhu, Mengyang Li, Zihan Dou, Zhonglian Cao, Xumeng Zhang, Shuwen Xu, Yuanzhen Zhang, Jun Lin, Xian Liang Zeng, Jiajun Fan, Xuyao Zhang, Xuebin Wang, Dianwen Ju

Journal for ImmunoTherapy of Cancer

DOI

2024

Dose escalation of KY-0118, PD-1, and IL-2v due-target fusion protein in patients with advanced renal clear cell carcinoma, urothelial carcinoma, and malignant melanoma.

Guoxiang Wu, Dianwen Ju, Yahui Su, Helen Yu

Journal of Clinical Oncology

DOI

2024

A Novel Bifunctional Fusion Protein (Anti-IL-17A-sST2) Protects against Acute Liver Failure, Modulating the TLR4/MyD88 Pathway and NLRP3 Inflammasome Activation

Yu Bai, Rongrui Zhou, Xinlei Xie, An Zhu, Yanyang Nan, Tao Wu, Xiaozhi Hu, Zhonglian Cao, Dianwen Ju, Jiajun Fan

Biomedicines

DOI

2024

A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

Yichen Wang, Yanyang Nan, Chunguang Ma, Xiaolin Lü, Qian Wang, Xiting Huang, Wenjing Xue, Jiajun Fan, Dianwen Ju, Dingwei Ye, Xuyao Zhang

Cell Death and Disease

DOI

2024

Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer

Kaiqi Zhang, Yuan Xu, Xusheng Chang, Caili Xu, Wenjing Xue, Dan Ding, Mingming Nie, Hui Cai, Jun Xu, Lu Zhan, Jiangbo Han, Tiancai Cai, Dianwen Ju, Li Feng, Xuyao Zhang, Kai Yin

Cancer Immunology Immunotherapy

DOI

2024

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Shuaiqi Wang, Dianwen Ju, Xian Liang Zeng

Biomedicines

DOI

2023

Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis

Yuting Zhang, Weijuan Xin, Xiaozhi Hu, Hanqi Wang, Xiaomiao Ye, Caili Xu, Yanyang Nan, Zhengyu Wu, Dianwen Ju, Jiajun Fan

Cell Death and Disease

DOI

2023

TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer

Caili Xu, Min Zhu, Qian Wang, Jiajun Cui, Yuping Huang, Xiting Huang, Jing Huang, Junwei Gai, Guanghui Li, Peng Qiao, Xian Liang Zeng, Dianwen Ju, Yakun Wan, Xuyao Zhang

Journal of Nanobiotechnology

DOI

2023

CMAUP database update 2024: extended functional and association information of useful plants for biomedical research

Dongyue Hou, Hanbo Lin, Yuhan Feng, Kaicheng Zhou, Xingxiu Li, Yuan Yang, Shuaiqi Wang, Xue Yang, Jiayu Wang, Hui Zhao, Xuyao Zhang, Jiajun Fan, SongLin Lu, Dan Wang, Lyuhan Zhu, Dianwen Ju, Yu Chen, Xian Liang Zeng

Nucleic Acids Research

DOI

2023

Correction: Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

Jinghui Zhang, Jiajun Fan, Xian Liang Zeng, Mingming Nie, Wei Chen, Yichen Wang, Jingyun Luan, Zeguo Zhu, Xusheng Chang, Dianwen Ju, Li Feng, Kai Yin

Cell Death and Disease

DOI

2023

Editorial: Combinational immunotherapy of cancer: novel targets, mechanisms, and strategies

Yanyang Nan, Dianwen Ju, Xuyao Zhang

Frontiers in Immunology

DOI

2023

Editorial: Community series in combinational immunotherapy of cancer: novel targets, mechanisms, and strategies, volume II

Caili Xu, Dianwen Ju, Xuyao Zhang

Frontiers in Immunology

DOI

2023

Innate Immunity in Cancer Biology and Therapy

Yuxia Zhang, Wenjing Xue, Caili Xu, Yanyang Nan, Shuang Mei, Dianwen Ju, Shaofei Wang, Xuyao Zhang

International Journal of Molecular Sciences

DOI

2023

Research progress of interleukin-15 in cancer immunotherapy

Menghan Cai, Xuan Huang, Xiting Huang, Dianwen Ju, Yi Zhun Zhu, Ye Li

Frontiers in Pharmacology

DOI

2023

Vunakizumab-IL22, a Novel Fusion Protein, Promotes Intestinal Epithelial Repair and Protects against Gut Injury Induced by the Influenza Virus

Chenchen Shi, Chang Su, Lifeng Cen, Lei Han, Jianguo Tang, Zetian Wang, Xunlong Shi, Dianwen Ju, Yiou Cao, Haiyan Zhu

Biomedicines

DOI

2023

Targeting CD47 Enhanced the Antitumor Immunity of PD-L1 Blockade in B-Cell Lymphoma

Yanyang Nan, Xuyao Zhang, Shaofei Wang, Caili Xu, Yichen Wang, Lei Han, Jingyun Luan, Xiaozhi Hu, Wei Chen, Zhonglian Cao, Zeguo Zhu, Xian Liang Zeng, Jiajun Fan, Li Ye, Xunlong Shi, Dianwen Ju

Immunotherapy

DOI

2023

Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response

Zhonglian Cao, Hui Zhao, Jiajun Fan, Yilan Shen, Lei Han, Guangjun Jing, Xian Liang Zeng, Xin Jin, Zeguo Zhu, Qi Bian, Yanyang Nan, Xiaozhi Hu, Xiaobin Mei, Dianwen Ju, Ping Yang

Cell Death Discovery

DOI

2022

A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice

Qianqian Ma, Xiaozhi Hu, Fangyu Liu, Zhonglian Cao, Lei Han, Kaicheng Zhou, Yu Bai, Yuting Zhang, Yanyang Nan, Qianying Lv, Jia Rao, Tao Wu, Xue Yang, Haidong He, Dianwen Ju, Hong Xu

Frontiers in Immunology

DOI

2022

Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma

Yichen Wang, Xuyao Zhang, Caili Xu, Yanyang Nan, Jiajun Fan, Xian Liang Zeng, Byoung S. Kwon, Dianwen Ju

Frontiers in Immunology

DOI

2022

NPASS database update 2023: quantitative natural product activity and species source database for biomedical research

Hui Zhao, Yuan Yang, Shuaiqi Wang, Xue Yang, Kaicheng Zhou, Caili Xu, Xuyao Zhang, Jiajun Fan, Dongyue Hou, Xingxiu Li, Hanbo Lin, Ying Ching Tan, Shanshan Wang, Xin‐Yi Chu, Zhuoma Dongzhi, Fengying Zhang, Dianwen Ju, Xian Liang Zeng, Yu Chen

Nucleic Acids Research

DOI

2022

Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma

Xiao‐Feng Zhu, Zhong‐Lin Sun, Jing Ma, Bo Hu, Mincheng Yu, Xiujie Liu, Ping Yang, Yang Xu, Dianwen Ju, Qing Mu

Phytotherapy Research

DOI

2022

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Xiaomiao Ye, Peng Zhang, Yuting Zhang, Jingyun Luan, Caili Xu, Zhengyu Wu, Dianwen Ju, Wei Hu

Frontiers in Immunology

DOI

2022

Characterization of light chain c-terminal extension sequence variant in one bispecific antibody

Jun Hong Lin, Mengyu Xie, Dan Liu, Zhen Gao, Xiaoyan Zhao, Hongxia Ma, Sheng Ding, Shu mei Li, Song Li, Yanling Liu, Fang Zhou, Hao Hu, Tao Chen, He Chen, Min Xie, Bo Yang, Jun Sheng Cheng, Mingjun Ma, Yanyang Nan, Dianwen Ju

Frontiers in Chemistry

DOI

2022

Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum

Tingting Liu, Yongliang Tong, Jinli Gao, Wenjing Fang, Junliang Wu, Xionghua Peng, Xiaotian Fan, Xiaoqiang Chen, Jianhua Sun, Sheldon Cao, Zhaohui Li, Likun Gong, Qiuping Qin, Dianwen Ju

Journal of Pharmacological and Toxicological Methods

DOI

2022

The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Si Fang, Dianwen Ju, Yong Qing Lin, Wei Chen

Frontiers in Immunology

DOI

2022

Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy

Caili Xu, Dianwen Ju, Xuyao Zhang

Frontiers in Immunology

DOI

2022

A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease

Xiaozhi Hu, Jiajun Fan, Qianqian Ma, Lei Han, Zhonglian Cao, Caili Xu, Jingyun Luan, Guangjun Jing, Yanyang Nan, Tao Wu, Yuting Zhang, Hanqi Wang, Yuanzhen Zhang, Dianwen Ju

Journal of Nanobiotechnology

DOI

2022

Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases

Qianqian Ma, Jingyun Luan, Yu Bai, Caili Xu, Fangyu Liu, Bufeng Chen, Dianwen Ju, Hong Ming Xu

Frontiers in Immunology

DOI

2022

A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer

Jiayang Liu, Zhefeng Meng, Tongyang Xu, Kudelaidi Kuerban, Songna Wang, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Wenzhi Tian, Xuan Huang, Xiting Huang, Danjie Pan, Huaning Chen, Weili Zhao, Li Ye

Frontiers in Immunology

DOI

2022

Chimeric antigen receptor T-cell therapy: challenges and opportunities in lung cancer

Caili Xu, Dianwen Ju, Xuyao Zhang

Antibody Therapeutics

DOI

2021

Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications

Wenjing Zai, Wei Chen, Hongrui Liu, Dianwen Ju

Biomedicines

DOI

2021

A Novel Bifunctional Fusion Protein, Vunakizumab-IL22, for Protection Against Pulmonary Immune Injury Caused by Influenza Virus

Lei Han, Chenchen Shi, Xian Liang Zeng, Lifeng Cen, Xiaobin Mei, Jiajun Fan, Dianwen Ju, Haiyan Zhu

Frontiers in Immunology

DOI

2021

Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates

Jinhua Zhang, Yuanzhen Dong, Dianwen Ju, Jun Feng

Bioorganic & Medicinal Chemistry

DOI

2021

Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

Jinghui Zhang, Jiajun Fan, Xian Liang Zeng, Mingming Nie, Wei Chen, Yichen Wang, Jingyun Luan, Zeguo Zhu, Xusheng Chang, Dianwen Ju, Li Feng, Kai Yin

Cell Death and Disease

DOI

2021

IL‐22‐mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

Wei Chen, Yilan Shen, Jiajun Fan, Xian Liang Zeng, Xuyao Zhang, Jingyun Luan, Yichen Wang, Jinghui Zhang, Si Fang, Xiaobin Mei, Zhen Zhao, Dianwen Ju

Clinical and Translational Medicine

DOI

2021

Neolignans from Piper betle Have Synergistic Activity against Antibiotic-Resistant Staphylococcus aureus

Chuan-Yun Xiao, Zhong‐Lin Sun, Jiao Huang, Rongsheng Li, Jian-Ming He, Simon Gibbons, Dianwen Ju, Qing Mu

The Journal of Organic Chemistry

DOI

2021

Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy

Ziyu Wang, Qinghong Xie, Haifeng Zhou, Min Zhang, Jie Shen, Dianwen Ju

Frontiers in Pharmacology

DOI

2020

内吞型EpCAM纳米抗体的筛选及鉴定

先宗树，李光辉，盖军伟，朱敏，马琳琳，鞠佃文，万亚坤

《药学学报》

DOI

2020

An Omalizumab Biobetter Antibody With Improved Stability and Efficacy for the Treatment of Allergic Diseases

Peipei Liu, Zhongzong Pan, Chunyin Gu, Xiaodan Cao, Xiaowu Liu, Jianjian Zhang, Zheng Xiao, Xueping Wang, Haibing Guo, Dianwen Ju, Su-Jun Deng

Frontiers in Immunology

DOI

2020

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

Jinghui Zhang, Jiajun Fan, Xian Liang Zeng, Mingming Nie, Jingyun Luan, Yichen Wang, Dianwen Ju, Kai Yin

Acta Pharmaceutica Sinica B

DOI

2020

MASI: microbiota—active substance interactions database

Xian Liang Zeng, Xue Yang, Jiajun Fan, Ying Ching Tan, Lingyi Ju, Wan Xiang Shen, Yali Wang, Xinghao Wang, Weiping Chen, Dianwen Ju, Yu Chen

Nucleic Acids Research

DOI

2020

Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index

Ting Shao, Tianzhi Chen, Yuning Chen, Xiaoyue Liu, Yili Chen, Qi Wang, Tong Zhu, Maojun Guo, Hui Li, Dianwen Ju, Chunhe Wang

Signal Transduction and Targeted Therapy

DOI

2020

The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Peipei Liu, Jiajun Fan, Ziyu Wang, Wenjing Zai, Ping Song, Yongping Li, Dianwen Ju

AMB Express

DOI

2020

Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses

Yilan Shen, Xin Jin, Wei Chen, Congrong Gao, Qi Bian, Jiajun Fan, Jingyun Luan, Zhonglian Cao, Zhiyong Guo, Yuting Gu, Hongrui Liu, Dianwen Ju, Xiaobin Mei

Applied Microbiology and Biotechnology

DOI

2020

Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

Wei Chen, Wenjing Zai, Jiajun Fan, Xuyao Zhang, Xian Liang Zeng, Jingyun Luan, Yichen Wang, Yilan Shen, Ziyu Wang, Shixuan Dai, Si Fang, Zhen Zhao, Dianwen Ju

Theranostics

DOI

2019

Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer

Xuyao Zhang, Yichen Wang, Jiajun Fan, Wei Chen, Jingyun Luan, Xiaobin Mei, Shaofei Wang, Yubin Li, Li Ye, Song Li, Wenzhi Tian, Kai Yin, Dianwen Ju

Journal for ImmunoTherapy of Cancer

DOI

2019

GSDMD membrane pore is critical for IL-1β release and antagonizing IL-1β by hepatocyte-specific nanobiologics is a promising therapeutics for murine alcoholic steatohepatitis

Jingyun Luan, Wei Chen, Jiajun Fan, Shaofei Wang, Xuyao Zhang, Wenjing Zai, Xin Jin, Yichen Wang, Zhenyi Feng, Jinghui Zhang, Ming‐Lin Liu, Dianwen Ju

Biomaterials

DOI

2019

Interleukin-22 Attenuated Renal Tubular Injury in Aristolochic Acid Nephropathy via Suppressing Activation of NLRP3 Inflammasome

Shaofei Wang, Jiajun Fan, Xiaobin Mei, Jingyun Luan, Yubin Li, Xuyao Zhang, Wei Chen, Yichen Wang, Guangxun Meng, Dianwen Ju

Frontiers in Immunology

DOI

2019

Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production

Jiajun Fan, Xuyao Zhang, Shaofei Wang, Wei Chen, Yubin Li, Xian Liang Zeng, Yichen Wang, Jingyun Luan, Li Li, Ziyu Wang, Xilin Sun, Baozhong Shen, Dianwen Ju

Cell Death and Disease

DOI

2019

Large-scale microcarrier culture of HEK293T cells and Vero cells in single-use bioreactors

Jianjun Yang, Patrick Guertin, Guodong Jia, Zhongliang Lv, Hongyan Yang, Dianwen Ju

AMB Express

DOI

2019

Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy

Ziyu Wang, Ping Song, Yubin Li, Shaofei Wang, Jiajun Fan, Xuyao Zhang, Jingyun Luan, Wei Chen, Yichen Wang, Peipei Liu, Dianwen Ju

Applied Microbiology and Biotechnology

DOI

2019

Recent Advances on Carbonyl Reductases for Dynamic Kinetic Resolution

Guowei Ni, Jiawei Tang, Jie Zou, Shaoxin Chen, Dianwen Ju, Fuli Zhang

Chinese Journal of Organic Chemistry

DOI

2018

In vivo hepatocellular expression of interleukin-22 using penetratin-based hybrid nanoparticles as potential anti-hepatitis therapeutics

Wei Chen, Jingyun Luan, Gang Wei, Xuyao Zhang, Jiajun Fan, Wenjing Zai, Shaofei Wang, Yichen Wang, Yanxu Liang, Yanyang Nan, Chuzhen Yin, Yubin Li, Ming‐Lin Liu, Dianwen Ju

Biomaterials

DOI

2018

Asymmetric Synthesis of Florfenicol by Dynamic Reductive Kinetic Resolution with Ketoreductases

Jie Zou, Guowei Ni, Jiawei Tang, Jun Yu, Luobin Jiang, Dianwen Ju, Fuli Zhang, Shaoxin Chen

European Journal of Organic Chemistry

DOI

2018

Inhibition of autophagy potentiated the anti-tumor effects of VEGF and CD47 bispecific therapy in glioblastoma

Xuyao Zhang, Shaofei Wang, Yanyang Nan, Jiajun Fan, Wei Chen, Jingyun Luan, Yichen Wang, Yanxu Liang, Song Li, Wenzhi Tian, Dianwen Ju

Applied Microbiology and Biotechnology

DOI

2018

Quantum Dots Elicit Hepatotoxicity through Lysosome-Dependent Autophagy Activation and Reactive Oxygen Species Production

Jiajun Fan, Shaofei Wang, Xuyao Zhang, Wei Chen, Yubin Li, Ping Yang, Zhonglian Cao, Yichen Wang, Weiyue Lu, Dianwen Ju

ACS Biomaterials Science & Engineering

DOI

2018

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

Xuyao Zhang, Jingyun Luan, Wei Chen, Jiajun Fan, Yanyang Nan, Yichen Wang, Yanxu Liang, Guangxun Meng, Dianwen Ju

Nanoscale

DOI

2017

Targeting TNFα Ameliorated Cationic PAMAM Dendrimer-Induced Hepatotoxicity via Regulating NLRP3 Inflammasomes Pathway

Yubin Li, Shaofei Wang, Jiajun Fan, Xuesai Zhang, Xiaolu Qian, Xuyao Zhang, Jingyun Luan, Ping Song, Ziyu Wang, Qicheng Chen, Dianwen Ju

ACS Biomaterials Science & Engineering

DOI

2015

Targeting Hedgehog signaling pathway and autophagy overcomes drug resistance of BCR-ABL-positive chronic myeloid leukemia

Xian Liang Zeng, Hui Zhao, Yubin Li, Jiajun Fan, Yun Sun, Shaofei Wang, Ziyu Wang, Ping Song, Dianwen Ju

Autophagy

DOI

2014

一种可用于大规模单克隆抗体纯化的新型Protein A填料

陈晓虹，吴建国，曹传平，唐亮，曾贤，范佳君，李玉彬，赵丽丽，刘增田，程凡亮，张继环，马连明，宋华，白文，鞠佃文

《中国生物制品学杂志》

2014

Qiangzhi Decoction (羌跖汤) protects mice from influenza A pneumonia through inhibition of inflammatory cytokine storm

Haiyan Zhu, Hai Yan Huang, Xunlong Shi, Wei Min Zhou, Pei Zhou, Qian-lin Yan, Hongguang Zhu, Dianwen Ju

Chinese Journal of Integrative Medicine

DOI

2014

Tyrosine kinase inhibitor Thiotanib targets Bcr-Abl and induces apoptosis and autophagy in human chronic myeloid leukemia cells

Jiajun Fan, Xiaochun Dong, Weixing Zhang, Xian Liang Zeng, Yubin Li, Yun Sun, Shaofei Wang, Ziyu Wang, Hongjian Gao, Weili Zhao, Dianwen Ju

Applied Microbiology and Biotechnology

DOI

2014

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

Haiyan Zhu, Xunlong Shi, Dianwen Ju, Hai Yan Huang, Wei Wei, Xiaoying Dong

Inflammation

DOI

2013

研讨型教学法在生物药物学教学中的实践与探索

朱海燕，冯美卿，鞠佃文

《药学教育》

2013

Pharmacokinetics and Pharmacodynamics of Recombinant Human EPO-Fc Fusion Protein In Vivo

Xunlong Shi, Jianjun Yang, Haiyan Zhu, Li Ye, Meiqing Feng, Jiyang Li, Hai Yan Huang, Qun Tao, Dan Ye, Lee-Hwei K. Sun, Bill N. C. Sun, Cecily R. Y. Sun, Gui‐Zhen Han, Yuanyuan Liu, Minghui Yao, Pei Zhou, Dianwen Ju

PLoS ONE

DOI

2013

Suppression of Autophagy Enhanced Growth Inhibition and Apoptosis of Interferon-β in Human Glioma Cells

Yubin Li, Haiyan Zhu, Xian Liang Zeng, Jiajun Fan, Xiaolu Qian, Shaofei Wang, Ziyu Wang, Yun Sun, Xiaodan Wang, Weiwu Wang, Dianwen Ju

Molecular Neurobiology

DOI

2012

细胞自噬在多柔比星诱导淋巴瘤细胞凋亡中的作用

范佳君，曾贤，李玉彬，王晓丹，王子玉，鞠佃文

《海军军医大学学报》

2011

人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白重组CHO细胞生产工艺及质控方法的建立

刘亚楠，吴建国，宓现强，陈晓虹，曹传平，朱军峰，管晏清，宋红梅，唐亮，郑玲莉，鞠佃文，陶群

《中国生物制品学杂志》

2011

rhEPO-Fc融合蛋白质量标准的研究

商阿丽，唐亮，曹传平，武雪宾，郑玲莉，何俊民，鞠佃文

《科技资讯》

2010

聚乙二醇干扰素α2b质控方法探讨

唐亮，陈晓虹，曹传平，郑玲莉，宋红梅，刘亚楠，汪世龙，鞠佃文

《药学前沿》

2009

聚乙二醇干扰素α2b在SD大鼠体内的药代动力学特征

吴建国，陈晓虹，宓现强，陶群，叶丹，鞠佃文

《中国生物制品学杂志》

2009

Therapeutic Effect of Recombinant Human Catalase on H1N1 Influenza-induced Pneumonia in Mice

Xunlong Shi, Zhihui Shi, Hai Yan Huang, Hongguang Zhu, Pei Zhou, Dianwen Ju

Inflammation

DOI

2008

胰岛素样生长因子-1基因原核表达载体的构建及表达蛋白的生物学活性

曹传平，陈晓虹，吴建国，商阿丽，虞慧华，康五朋，郑玲莉，张敬，鞠佃文

《中国生物制品学杂志》

2007

rhEPO-Fc融合蛋白的表达、纯化及质量研究

杨建军，张昕泂，周洁，龚振，陶群，叶丹，汪世龙，鞠佃文

《中国生物工程杂志》

DOI

2004

131I-肿瘤细胞核人鼠嵌合单抗肿瘤治疗内照射吸收剂量估算

陈仰纯，陈绍亮，鞠佃文，石洪成，姚之丰

《中华核医学与分子影像杂志》

2004

131碘肿瘤细胞核人鼠嵌合单抗药代动力学研究

陈仰纯，陈绍亮，鞠佃文，石洪成，许开平，许长德

《中国药科大学学报》

2000

p16基因修饰的小鼠肾癌细胞体内致瘤性观察

王林辉，闵志廉，钱松溪，孙颖浩，弭静，鞠佃文，曹雪涛

《中华泌尿外科杂志》

2000

p16与粒细胞-巨噬细胞集落刺激因子联合基因疗法治疗小鼠肾癌的研究

王林辉，孙颖浩，钱松溪，闵志廉，弭静，鞠佃文，曹雪涛

《中华实验外科杂志》

2000

p16基因转染肾癌细胞体外生物学特性的研究

王林辉，孙颖浩，钱松溪，弥静，鞠佃文，曹雪涛，闵志廉

《中华泌尿外科杂志》

1999

CD自杀基因联合GM-CSF基因治疗的抗肿瘤作用及免疫机理

鞠佃文，曹雪涛，王宝梅，银平章，万涛，陶群，章卫平

《中华微生物学和免疫学杂志》

1999

Tetramer的制备及以树突状细胞为基础的肿瘤免疫治疗中抗原特异性CD8+T细胞的研究

鞠佃文，曹雪涛，陶群，章卫平，于益芝，项莺松，林锫，陈国友，张明徽

《中国肿瘤生物治疗杂志》

1999

一种与TNF-α同源的新型细胞因子生物学功能的初步研究

于益芝，曹雪涛，刘书逊，章卫平，弭静，张明徽，赵勇，陶群，鞠佃文

《中国肿瘤生物治疗杂志》

1999

Augmentation of antitumor effect of adenovirus-mediated CD suicide gene therapy by cotransfer of interleukin 2 gene in melanoma-bearing mice

鞠佃文，曹雪涛，陶群，王宝梅，陈国友，于益芝

《中华医学杂志(英文版)》

1999

CD8+T细胞Tc1和Tc2细胞亚群研究进展

徐振宇，鞠佃文

《中国肿瘤生物治疗杂志》

1999

p16和GM-CSF联合基因疗法治疗肾癌的研究

王林辉，鞠佃文，弭静，曹雪涛

《中国肿瘤生物治疗杂志》

1999

人骨髓、脐血CD34+干细胞体外扩增的树突状细胞的表型及其T细胞刺激活性分析

朱学军，曹雪涛，马施华，章卫平，鞠佃文，于益芝，陈国友

《中国肿瘤生物治疗杂志》

1998

联合自杀基因与IL-2基因转移疗法的抗肿瘤效果及其抗肿瘤免疫应答的诱导作用

鞠佃文，曹雪涛，王宝梅，孔令非，银平章，陶群，万涛，于益芝

《中国肿瘤生物治疗杂志》

1998

细胞因子基因与自杀基因联合应用研究进展

徐振宇，鞠佃文，曹雪涛

《国际肿瘤学杂志》

1998

重组痘苗病毒介导的IL-2抗小鼠FBL-3细胞肿瘤的实验研究

葛林阜，曹雪涛，鞠佃文，万涛，于益芝，马施华，叶天星

《解放军医学杂志》

1998

腺病毒介导的胞嘧啶脱氨酶自杀基因联合IL-2基因疗法的肿瘤治疗作用及免疫机理分析

鞠佃文，曹雪涛，王宝梅，万涛，陶群，陈国友，章卫平

《中华肿瘤杂志》

1998

T细胞及相关免疫分子在淋巴细胞趋化因子增强肿瘤自杀基因疗法中的作用

鞠佃文，曹雪涛，章卫平，陶群，张明徽，于益芝，陈国友，程大胜

《中国肿瘤生物治疗杂志》

1998

CD自杀基因联合淋巴细胞趋化因子基因疗法的肿瘤治疗作用及免疫机理研究

程大胜，曹雪涛，鞠佃文，章卫平，王建莉，陶群，张明徽，朱学军，袁正隆

《中国肿瘤生物治疗杂志》

1998

腺病毒介导的CD/5FC自杀基因疗法对小鼠结肠腺癌的治疗作用及相关免疫机理的研究

黄欣，曹雪涛，鞠佃文，章卫平，王建莉，陶群

《中国肿瘤生物治疗杂志》

1998

大肠杆菌CD自杀基因转染诱导肿细胞凋亡及旁观者效应的研究

王宝梅，曹雪涛，鞠佃文，银平章，孔令非，万涛，陶群，于益芝

《中国肿瘤生物治疗杂志》

1998

腺病毒介导的大肠杆菌CD自杀基因体内外对肿瘤杀伤作用的研究

王宝梅，孔令非，银平章，曹雪涛，鞠佃文，万涛，陶群，于益芝

《中国肿瘤生物治疗杂志》

1998

IFN-β临床应用研究进展

徐振宇，鞠佃文，田野苹，曹雪涛

《中国肿瘤生物治疗杂志》

1998

EFFICIENT ACTIVATION OF ANTITUMOR IMMUNITY BY IL-6 GENE-MODIFIED LEUKEMIA VACCINE IN COMBINATION WITH LOW DOSE CYCLOPHOSPHAMIDE AND LOW DOSEIL-2

曹雪涛，葛林阜，鞠佃文，陶群，于益芝

Chinese Journal of Cancer Research

1998

INDUCTION OF IMMUNE RESPONSE BY IL-6 GENEMODIFIED LEUKEMIA CELLS

曹雪涛，葛林阜，鞠佃文，于益芝，陶群，章卫平

Chinese Journal of Cancer Research

1998

ENHANCED ANTITUMOR EFFECTS OF SUICIDE GENE THERAPY BY SIMULTANEOUS TRANSFER OF GMCSF GENE IN LEUKEMIA-BEARING MICE

鞠佃文，曹雪涛，于益芝，陶群，王宝梅，万涛

Chinese Journal of Cancer Research

1998

成纤维细胞介导的人IL-10基因疗法的实验研究

陈敏亮，林子豪，曹雪涛，章卫平，陶群，鞠佃文，雷虹，吴宏，宋慧锋

《海军军医大学学报》

1998

大肠杆菌CD自杀基因与GM-CSF基因联合转移对小鼠红白血病的治疗作用

鞠佃文，曹雪涛，王宝梅，孔令非，银平，章万涛，陶群，章卫平

《中华血液学杂志》

1998

人IL-2重组痘苗病毒转染的肿瘤细胞破碎物小鼠体内抗肺转移作用

万涛，曹雪涛，鞠佃文，陈国友，章卫平，陶群，于益芝

《中华微生物学和免疫学杂志》

1997

细胞因子检测技术及其应用

鞠佃文，曹雪涛

《中国实验诊断学》

1997

IL-2基因与自杀基因联合转移对小鼠红白血病的治疗作用

王宝梅，曹雪涛，鞠佃文，陶群，于益芝，孔令非，银平章

《中国肿瘤生物治疗杂志》

1997

分泌粒细胞-巨噬细胞集落刺激因子的重组痘苗病毒转染的瘤苗裂解物抗肿瘤作用

鞠佃文，曹雪涛，万涛，陶群，于益芝，章卫平

《中华微生物学和免疫学杂志》

1997

自杀基因与GM-CSF基因联合治疗对小鼠黑色素瘤的治疗作用及其机理研究

鞠佃文，曹雪涛，王宝梅，银平章，陶群，于益芝

《中国肿瘤生物治疗杂志》

1997

ANTITUMOR EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR(GM-CSF)-GENE ENCODED VACCINIA MELANOMA ONCOLYSATE AND ITS IMMUNOLOGICAL MECHANISMS

鞠佃文，曹雪涛，万涛，章卫平，陶群，于益芝，陈国友

Chinese Journal of Cancer Research

1997

ANTI-METASTATIC EFFECT OF ONCOLYSATES FROM MURINE MELANOMA CELLS TRANSFECTED WITH RECOMBINANT VACCINIA VIRUS ENCODING HUMAN IL-2

万涛，曹雪涛，鞠佃文，于益芝，陶群，雷虹

Chinese Journal of Cancer Research

1997

重组痘苗病毒载体介导的IL-2基因局部转染对小鼠黑色素瘤的治疗作用

万涛，曹雪涛，刘江秋，鞠佃文，陶群，陈国友，章卫平，于益芝

《中国免疫学杂志》

1997

EFFECTS OF GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR GENE ENCODED VACCINIA VIRUS VECTOR ON MURINE PULMONARY METASTATIC MELANOMA

鞠佃文，曹雪涛，万涛，马施华，王宝梅，于益芝，叶天星

Chinese Journal of Cancer Research

1996

肿瘤的直接体内途径基因治疗研究进展

鞠佃文，曹雪涛

《国际肿瘤学杂志》

1996

核酶在肿瘤基因治疗中的应用

鞠佃文，曹雪涛

《中国肿瘤生物治疗杂志》

1996

肿瘤抗原靶向的基因治疗研究进展

鞠佃文，曹雪涛

《国际肿瘤学杂志》

1996

一氧化氮在肿瘤生长中的作用

鞠佃文

《国际肿瘤学杂志》

1996

腺病毒介导的肝癌自杀基因疗法的实验研究

黄欣，曹雪涛，章卫平，鞠佃文，张明徽，肖农，陈国友，万涛，HirofumiHamada

《中国肿瘤生物治疗杂志》

1996

腹腔注射分泌粒细胞－巨噬细胞集落刺激因子的重组痘苗病毒的抗肿瘤肺转移作用

鞠佃文，曹雪涛，马施华，万涛，陈敏亮，于益芝

《中华肿瘤杂志》

1996

IL-2重组痘苗病毒修饰的肿瘤细胞破碎物局部应用后的抗肿瘤作用研究

万涛，曹雪涛，鞠佃文，于益芝，章卫平，刘江秋，陶群

《中国肿瘤生物治疗杂志》

1996

逆转录病毒载体上清介导的人葡萄糖脑苷脂酶基因转染CD34+造血干细胞后在灵长类动物体内的长期表达

鞠佃文

《中国肿瘤生物治疗杂志》

1995

在SCTD—hu小鼠体内模仿人淋巴前体细胞基因治疗

鞠佃文

《中国肿瘤生物治疗杂志》

1995

表面活性蛋白A-聚赖氨酸结合物将DNA转染至培养的呼吸道细胞中

鞠佃文

《中国肿瘤生物治疗杂志》

1995

抗病毒药物选择性增强照射对于HSV-tk基因转染人神经胶质瘤细胞的杀伤作用

鞠佃文

《中国肿瘤生物治疗杂志》

1995

腺病毒载体转染人骨髓细胞

鞠佃文

《中国肿瘤生物治疗杂志》

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A potent anti-CD47 antibody decoupling anti-tumor efficacy from hematotoxicity

Anti-ANGPTL3 antibody and IL-22 fusion protein mitigate nephrotic syndrome via mitochondrial protection, anti-apoptosis, and autophagy suppression

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Integrative Transcriptomic Analysis Identifies COL3A1 as a Potential Tumor-Intrinsic Therapeutic Target in NSCLC

Targeting angiopoietin-like protein 3 and interleukin-1β alleviated liver and kidney injury through attenuation of lipotoxicity and regulation of glycolipid metabolism in db/db mice

EGFR-targeted therapies based on antibody engineering and nanotechnology for colorectal cancer

Rubicon siRNA-encapsulated liver-targeting nanoliposome is a promising therapeutic for non-alcoholic fatty liver disease

A Dual CRISPR-Cas/Cre- loxP Genome Engineering Strategy for Stable Uricase Expression in Food-Grade Probiotics

MASI2.0: Insights of Microbiota Metabolic Potential from Incorporating Genomic Information on Microbiota-Active Substance Interactions

MiRNA-based drugs: challenges and delivery strategies

NPASS database update 2026: comprehensive quantitative composition, bioactivity, and ADME-Tox data of natural products for biomedical research

ANGPTL3 nanobody-FGF21 fusion protein ameliorates metabolic dysfunction-associated fatty liver disease via regulation of lipid and glucose metabolism and attenuation of oxidative stress

Improved biodistribution and antitumor effects of a Nectin4 and Trop2 bispecific fatty acid-modified nanobody conjugate

Enhanced Generalizability of RNA Secondary Structure Prediction via Convolutional Block Attention Network and Ensemble Learning

TargetPair: A Single Cell-omics Resource of Clinical Trials-derived Therapeutical Target Combinations for Cancer Therapy

DDR1 Drives Collagen Remodeling and Immune Exclusion: Pan-Cancer Insights and Therapeutic Targeting in Pancreatic Ductal Adenocarcinoma

Nanobody-engineered bispecific IL-18 mimetics drive antitumor immunity by engaging CD8+ T cell and evading IL-18BP in preclinical models

Chemical Structure-based Graph Convolutional Model for Drug-Gut Microbiota Association Prediction

A Hyperbolic Discrete Diffusion 3D RNA Inverse Folding Model for Functional RNA Design

Rational Design of Site-Specific Fatty Acid Derivatives to Extend the Half-Life of Fibroblast Growth Factor 21

Enhancing catalytic efficiency of two microbial uricases making by directed evolution

IL-2-loaded liposomes modified with sorafenib derivative exert a synergistic anti-melanoma effect via improving tumor immune microenvironment and enhancing antiangiogenic activity

Development of an anti-LAIR1 antibody-drug conjugate for acute myeloid leukemia therapy

Lipid Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism

Prediction of human gut microbiota-drug associations based on multiple graph convolutional networks

Lipidation-dimerization platform unlocks treatment potential of fibroblast growth factor 21 for non-alcoholic steatohepatitis

Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation

Natural killer cell engagers: From bi‐specific to tri‐specific and tetra‐specific engagers for enhanced cancer immunotherapy

Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer

Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer

Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation

Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer

Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy

Dose escalation of KY-0118, PD-1, and IL-2v due-target fusion protein in patients with advanced renal clear cell carcinoma, urothelial carcinoma, and malignant melanoma.

A Novel Bifunctional Fusion Protein (Anti-IL-17A-sST2) Protects against Acute Liver Failure, Modulating the TLR4/MyD88 Pathway and NLRP3 Inflammasome Activation

A potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE

Co-targeting CD47 and VEGF elicited potent anti-tumor effects in gastric cancer

Mechanisms and Clinical Implications of Human Gut Microbiota-Drug Interactions in the Precision Medicine Era

Inhibition of Hedgehog signaling ameliorates foam cell formation by promoting autophagy in early atherosclerosis

TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer

CMAUP database update 2024: extended functional and association information of useful plants for biomedical research

Correction: Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

Editorial: Combinational immunotherapy of cancer: novel targets, mechanisms, and strategies

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Innate Immunity in Cancer Biology and Therapy

Research progress of interleukin-15 in cancer immunotherapy

Vunakizumab-IL22, a Novel Fusion Protein, Promotes Intestinal Epithelial Repair and Protects against Gut Injury Induced by the Influenza Virus

Targeting CD47 Enhanced the Antitumor Immunity of PD-L1 Blockade in B-Cell Lymphoma

Simultaneous blockade of VEGF-B and IL-17A ameliorated diabetic kidney disease by reducing ectopic lipid deposition and alleviating inflammation response

A novel fusion protein consisting of anti-ANGPTL3 antibody and interleukin-22 ameliorates diabetic nephropathy in mice

Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma

NPASS database update 2023: quantitative natural product activity and species source database for biomedical research

Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis

Characterization of light chain c-terminal extension sequence variant in one bispecific antibody

Development of a bridging ELISA for detection of antibodies against ZV0203 in cynomolgus monkey serum

The role of interleukin-22 in lung health and its therapeutic potential for COVID-19

Cell Membrane-Derived Vesicle: A Novel Vehicle for Cancer Immunotherapy

A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease

Interleukin-22 in Renal Protection and Its Pathological Role in Kidney Diseases

A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer

Chimeric antigen receptor T-cell therapy: challenges and opportunities in lung cancer

Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease: From Molecular Mechanisms to Clinical Applications

A Novel Bifunctional Fusion Protein, Vunakizumab-IL22, for Protection Against Pulmonary Immune Injury Caused by Influenza Virus

Design, synthesis and biological evaluation of double fatty chain-modified glucagon-like peptide-1 conjugates

Targeting the autophagy promoted antitumor effect of T-DM1 on HER2-positive gastric cancer

IL‐22‐mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

Neolignans from Piper betle Have Synergistic Activity against Antibiotic-Resistant Staphylococcus aureus

Amino Acid Degrading Enzymes and Autophagy in Cancer Therapy

内吞型EpCAM纳米抗体的筛选及鉴定

An Omalizumab Biobetter Antibody With Improved Stability and Efficacy for the Treatment of Allergic Diseases

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

MASI: microbiota—active substance interactions database

Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index

The role of autophagy in the cytotoxicity induced by trastuzumab emtansine (T-DM1) in HER2-positive breast cancer cells

Interleukin-22 ameliorated acetaminophen-induced kidney injury by inhibiting mitochondrial dysfunction and inflammatory responses

Interleukin-22 drives a metabolic adaptive reprogramming to maintain mitochondrial fitness and treat liver injury

Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer