吴家强｜五邑大学｜学者主页

2026

Synthesis of isoquinolin-1,4-diones via photocatalytic C(sp 2 )–C(sp 3 )-scission/oxidation of 4-(hydroxy(aryl)methyl)-isoquinolin-1(2 H )-ones

Taotao Zhao, Qianyi Liang, Keying Gu, Jiangbin Huang, Jiangbin Huang, Jinhui Hu, Jia‐Qiang Wu

Chemical Communications

DOI

2025

含氮杂环衍生物的设计、合成及抗炎活性研究

何登芹，欧扬慧，李刚，吴家强，姚宏亮

《广州化学》

DOI

2025

Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment

Lian Chen, Zhonghui Lu, Yunfei Hu, Lanqing Li, Jia‐Qiang Wu, Wen‐Hua Chen, Jinhui Hu

Journal of Medicinal Chemistry

DOI

2025

Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles

Mei Xie, Zhenli Luo, Chunming Chen, Zhuang Xiong, Jinhui Hu, Jia‐Qiang Wu

Organic Letters

DOI

2025

Merocyanine derivative for real-time imaging of amyloid-β and inhibition of self-aggregation and MAO-B activity

Hua Liu, Shun Li, Xinrui Li, Shuanglong Li, Jia‐Qiang Wu, Daoyuan Chen, Chunli Xia

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2025

The crystal structure of 2-benzoyl-3′,4′,5′,6′-tetrahydrospiro[isoindoline-1,2′-pyran]-3-one, C19H17NO3

Tao-Tao Zhao, Jia‐Qiang Wu, Haiping Wang

Zeitschrift für Kristallographie - New Crystal Structures

DOI

2025

Ferroptosis of Cancer Cells via Tubulin Degradation and Mitochondrial Dysfunction: A Novel Mechanism of Anticancer Effect for Small-Molecule Anion Transporters

Xiao-Qiao Hong, Li Chen, Xi-Hui Yu, Lanqing Li, Jia‐Qiang Wu, Jinhui Hu, Qin-Chao Mao, Wen‐Hua Chen

Journal of Medicinal Chemistry

DOI

2025

Development of novel melatonin-isatin hybrids as multifunctional agents for Alzheimer’s disease

Yingying Zhong, Jun-Ze Deng, Qin Wang, Li Bo Chen, Zhi‐gang Yang, Yamei Zhang, Luyi Zhou, Yiran Li, Jia‐Qiang Wu, Xiaoqin Wang

Molecular Diversity

DOI

2025

Rh( iii )-catalyzed C–H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif

Wei Lin, Zhenli Luo, Huixuan Zhu, Jinhui Hu, Zhuang Xiong, Jia‐Qiang Wu

Chemical Communications

DOI

2025

Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging

Qingxiu Chen, Shuanglong Li, Shun Li, Peipei Tong, Ruping Li, Jia‐Qiang Wu, Chunli Xia, Daoyuan Chen

Analytical Methods

DOI

2024

Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis

Dengqin He, Gang Li, Jia‐Qiang Wu, Yan Geng, Xudong Qian, Yuanhui Liu, Yanghui Ou, Mengjie Li, Jun Wang, Wei Pan, Guoping Zhang, Dandan Chen, Jiaxin Chen, Zichen Xu, Hengming Ke, Hongliang Yao

Journal of Medicinal Chemistry

DOI

2024

Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

Wen‐Hua Chen, Jun Xu, Jia‐Qiang Wu, Wei Lin, Yifei Qu, Huixuan Zhu, Mei Xie, Jinhui Hu, Zhuang Xiong

Synthesis

DOI

2024

Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates

Hai-Tao Zhi, Zhonghui Lu, Li Chen, Jia‐Qiang Wu, Lanqing Li, Jinhui Hu, Wen‐Hua Chen

Bioorganic Chemistry

DOI

2024

One-pot sequential synthesis of unsymmetrical diarylmethanes using methylene chloride as a C1-synthon

Xueli Cui, Chunming Chen, Mei Xie, Taotao Zhao, Jianfeng Yi, Weiqiang Sun, Zhuang Xiong, Jinhui Hu, Wing‐Leung Wong, Jia‐Qiang Wu

Organic & Biomolecular Chemistry

DOI

2023

Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines

Yifei Qu, Xiaojia Cai, Yuzhuang Guan, Jiamin Tan, Zhangping Cai, Minyun Liu, Ya-Si Huang, Jinhui Hu, Wen‐Hua Chen, Jia‐Qiang Wu

Organic & Biomolecular Chemistry

DOI

2023

Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2

Li Chen, Yunfei Hu, Zhonghui Lu, Zeyin Lin, Lanqing Li, Jia‐Qiang Wu, Zhi‐Ling Yu, Chunye Wang, Wen‐Hua Chen, Jinhui Hu

Journal of Medicinal Chemistry

DOI

2023

Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Liyan Song, Gang Li, Wen Guan, Zhijun Zeng, Yanghui Ou, Tongchao Zhao, Jiayu Li, Dengqin He, Xiangxiang Fang, Yali Zhang, Jia‐Qiang Wu, Rongbiao Tong, Hongliang Yao

Biomedicine & Pharmacotherapy

DOI

2023

Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines

Zhuang Xiong, Chunmei Hu, Wenjian Zhu, Simin Wu, Dan Wang, Yang Liu, Jing Lin, Suqin Guo, Jia‐Qiang Wu, Xuetao Xu

The Journal of Organic Chemistry

DOI

2023

Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Ren‐Xian Tan, Weihao Li, Jia-Min Pang, Si-Min Zhong, Xin-Yi Huang, Jun-Ze Deng, Luyi Zhou, Jia‐Qiang Wu, Xiaoqin Wang

Molecular Diversity

DOI

2023

Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Gang Li, Jia‐Qiang Wu, Xiaojia Cai, Wen Guan, Zhijun Zeng, Yanghui Ou, Xiaoyun Wu, Jiayu Li, Xiangxiang Fang, Jinling Liu, Yali Zhang, Huamin Wang, Canqiang Yin, Hongliang Yao

European Journal of Medicinal Chemistry

DOI

2023

Synthesis of α-Boryl Ketones via Hydration or Oxidation of B(MIDA)-Decorated Alkynes

Zhi-Hao Chen, Xiaoxuan Su, Qingjiang Li, Jia‐Qiang Wu, Tian‐Miao Ou, Honggen Wang

Organic Letters

DOI

2023

Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Jinhui Hu, Li Chen, Zhonghui Lu, Han Yao, Yunfei Hu, Luanqi Feng, Yanqing Pang, Jia‐Qiang Wu, Zhi‐Ling Yu, Wen‐Hua Chen

Molecules

DOI

2023

Rh( iii )-catalyzed redox-neutral C–H alkenylation of benzamides with gem -difluorohomoallylic silyl ethers via β-H elimination

Xueli Cui, Jing Qu, Jianfeng Yi, Weiqiang Sun, Jinhui Hu, Suqin Guo, Jingwei Jin, Wen‐Hua Chen, Wing‐Leung Wong, Jia‐Qiang Wu

Chemical Communications

DOI

2023

Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines

Weiqiang Sun, Xueli Cui, Jing Qu, Xiaojia Cai, Jinhui Hu, Zhuang Xiong, Suqin Guo, Jun Xu, Wen‐Hua Chen, Jia‐Qiang Wu

Chemical Communications

DOI

2022

Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization

Yunfei Hu, Li Chen, Canlin Zou, Jiangtao He, Luanqi Feng, Jia‐Qiang Wu, Wen‐Hua Chen, Jinhui Hu

Organic Letters

DOI

2022

Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity

Borong Tu, Jinfeng Liang, Yi Ou, Xinyue Zhang, Wende Zheng, Rihui Wu, Li‐She Gan, Dongli Li, Yu‐Jing Lu, Jia‐Qiang Wu, Weiqian David Hong, Kun Zhang, Panpan Wu, Jingwei Jin, Wing‐Leung Wong

Bioorganic Chemistry

DOI

2022

CpIr( iii ) and CpRh( iii )-catalyzed annulation of salicylaldehydes with fluorinated vinyl tosylates

Shuwen Zhao, Xiaojia Cai, Yuying Lu, Jinhui Hu, Zhuang Xiong, Jingwei Jin, Yin Li, Honggen Wang, Jia‐Qiang Wu

Chemical Communications

DOI

2022

Synthesis of difluoromethyl carbinols from the Friedel–Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates

Xiaojia Cai, Jinyuan Xu, Xueli Cui, Jing Qu, Weiqiang Sun, Jinhui Hu, Shuwen Zhao, Wen‐Hua Chen, Hongliang Li, Jia‐Qiang Wu

Organic Chemistry Frontiers

DOI

2021

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Xiao‐Qin Wang, Luyi Zhou, Ren‐Xian Tan, Guo‐Peng Liang, Si‐Xian Fang, Wei Li, Mei Xie, Yu‐Hao Wen, Jia‐Qiang Wu, Yiping Chen

Chemistry & Biodiversity

DOI

2021

Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors

Chengjun Wu, Jia‐Qiang Wu, Yunfei Hu, Suyun Pu, Yuying Lin, Zimai Zeng, Jinhui Hu, Wen‐Hua Chen

European Journal of Medicinal Chemistry

DOI

2021

Rhodium( iii )-catalyzed C–H/C–F activation sequence: expedient and divergent synthesis of 2-benzylated indoles and 2,2′-bis(indolyl)methanes

Bing Shu, Shaoyong Chen, Nan-Xiang Deng, Tao Zheng, Hui Xie, Xiaoling Xie, Jia‐Qiang Wu, Hua Cao, Shang‐Shi Zhang

Organic Chemistry Frontiers

DOI

2020

CpIr( iii )- and CpRh( iii )-catalyzed C(sp 2 )–H amination of arenes using thioethers as directing groups

Hui Xie, Mei Zhong, Xiaotong Wang, Jia‐Qiang Wu, Yanqu Cai, Jidan Liu, Bing Shu, Tong Che, Shang‐Shi Zhang

Organic Chemistry Frontiers

DOI

2020

Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Yanwen Li, Chanjuan Li, Jia‐Qiang Wu, Wenfeng Liu, Dongli Li, Jun Xu

RSC Advances

DOI

2019

Cu‐Mediated C7 Acetoxylation of Indolines

Shanshan Gao, Xing Xu, Hao Tang, Jia‐Qiang Wu, Junfei Luo

ChemistrySelect

DOI

吴家强

精选作品

期刊论文

Synthesis of isoquinolin-1,4-diones via photocatalytic C(sp 2 )–C(sp 3 )-scission/oxidation of 4-(hydroxy(aryl)methyl)-isoquinolin-1(2 H )-ones

含氮杂环衍生物的设计、合成及抗炎活性研究

Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment

Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles

Merocyanine derivative for real-time imaging of amyloid-β and inhibition of self-aggregation and MAO-B activity

The crystal structure of 2-benzoyl-3′,4′,5′,6′-tetrahydrospiro[isoindoline-1,2′-pyran]-3-one, C19H17NO3

Ferroptosis of Cancer Cells via Tubulin Degradation and Mitochondrial Dysfunction: A Novel Mechanism of Anticancer Effect for Small-Molecule Anion Transporters

Development of novel melatonin-isatin hybrids as multifunctional agents for Alzheimer’s disease

Rh( iii )-catalyzed C–H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif

Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging

Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis

Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates

One-pot sequential synthesis of unsymmetrical diarylmethanes using methylene chloride as a C1-synthon

Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines

Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2

Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines

Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Synthesis of α-Boryl Ketones via Hydration or Oxidation of B(MIDA)-Decorated Alkynes

Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Rh( iii )-catalyzed redox-neutral C–H alkenylation of benzamides with gem -difluorohomoallylic silyl ethers via β-H elimination

Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines

Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization

Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity

CpIr( iii ) and CpRh( iii )-catalyzed annulation of salicylaldehydes with fluorinated vinyl tosylates

Synthesis of difluoromethyl carbinols from the Friedel–Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors

Rhodium( iii )-catalyzed C–H/C–F activation sequence: expedient and divergent synthesis of 2-benzylated indoles and 2,2′-bis(indolyl)methanes

CpIr( iii )- and CpRh( iii )-catalyzed C(sp 2 )–H amination of arenes using thioethers as directing groups

Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Cu‐Mediated C7 Acetoxylation of Indolines

研究方向

精选作品

期刊论文

Synthesis of isoquinolin-1,4-diones via photocatalytic C(sp 2 )–C(sp 3 )-scission/oxidation of 4-(hydroxy(aryl)methyl)-isoquinolin-1(2 H )-ones

含氮杂环衍生物的设计、合成及抗炎活性研究

Dual Induction of Ferroptosis and Apoptosis by Triazolopyrimidinyl Derivatives: Design, Synthesis, and Biological Evaluation for Their Anticancer Efficacy via Calcium/Calmodulin Signaling and Mitochondrial Impairment

Palladium-Catalyzed [4+1] Cycloaddition of 3,3-Difluoropent-4-en-2-ones with Amines: A Modular Approach to 3-Fluoropyrroles

Merocyanine derivative for real-time imaging of amyloid-β and inhibition of self-aggregation and MAO-B activity

The crystal structure of 2-benzoyl-3′,4′,5′,6′-tetrahydrospiro[isoindoline-1,2′-pyran]-3-one, C19H17NO3

Ferroptosis of Cancer Cells via Tubulin Degradation and Mitochondrial Dysfunction: A Novel Mechanism of Anticancer Effect for Small-Molecule Anion Transporters

Development of novel melatonin-isatin hybrids as multifunctional agents for Alzheimer’s disease

Rh( iii )-catalyzed C–H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif

Rational construction of a simplified hemicyanine-based fluorescent probe CCX-1 with dual pH and viscosity response for lysosome-specific tumour imaging

Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis

Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides

Anticancer efficacy triggered by synergistically modulating the homeostasis of anions and iron: Design, synthesis and biological evaluation of dual-functional squaramide-hydroxamic acid conjugates

One-pot sequential synthesis of unsymmetrical diarylmethanes using methylene chloride as a C1-synthon

Divergent synthesis of difluoromethylated indole-3-carbinols, bisindolylmethanes and indole-3-methanamines

Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2

Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Bicyclic Amidine-Triggered Cyclization of o-Alkynylisocyanobenzenes: Synthesis of Lactam-Derived Quinolines

Design, synthesis, and evaluation of 2,2’-bipyridyl derivatives as bifunctional agents against Alzheimer’s disease

Design, synthesis, and biological evaluation of diaryl heterocyclic derivatives targeting tubulin polymerization with potent anticancer activities

Synthesis of α-Boryl Ketones via Hydration or Oxidation of B(MIDA)-Decorated Alkynes

Design, Synthesis and Antitumor Activity of Novel Selenium-Containing Tepotinib Derivatives as Dual Inhibitors of c-Met and TrxR

Rh( iii )-catalyzed redox-neutral C–H alkenylation of benzamides with gem -difluorohomoallylic silyl ethers via β-H elimination

Facile access to 2-hydroxy-2-substituted indole-3-ones via a copper-catalyzed oxidative cyclization of 2-arylethynylanilines

Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization

Novel 18β-glycyrrhetinic acid derivatives as a Two-in-One agent with potent antimicrobial and anti-inflammatory activity

Cp*Ir( iii ) and Cp*Rh( iii )-catalyzed annulation of salicylaldehydes with fluorinated vinyl tosylates

Synthesis of difluoromethyl carbinols from the Friedel–Crafts reaction of electron-rich arenes with difluorovinyl arylsulfonates

Design, Synthesis, and Evaluation of Chalcone Derivatives as Multifunctional Agents against Alzheimer's Disease

Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors

Rhodium( iii )-catalyzed C–H/C–F activation sequence: expedient and divergent synthesis of 2-benzylated indoles and 2,2′-bis(indolyl)methanes

Cp*Ir( iii )- and Cp*Rh( iii )-catalyzed C(sp 2 )–H amination of arenes using thioethers as directing groups

Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Cu‐Mediated C7 Acetoxylation of Indolines

研究方向

CpIr( iii ) and CpRh( iii )-catalyzed annulation of salicylaldehydes with fluorinated vinyl tosylates

CpIr( iii )- and CpRh( iii )-catalyzed C(sp 2 )–H amination of arenes using thioethers as directing groups