陈海峰｜厦门大学｜学者主页

2026

一种靶向核受体RXRα-自噬通路的天然化合物的抗肿瘤作用机制研究

申诗瑀，张锦雯，刘梦晖，刘婕，田文静，陈海峰，于瑞涛，王光辉

《中国中药杂志》

2026

Spiro-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum monogynum and Their anti-Alzheimer’s Disease Effects

Wenjing Tian, 何守伦, Tingjiya Wang, Shengfei Zhong, Jingyu Sun, Junjie Chen, Xiaoyi Wang, Chunchun Du, Yuhang You, Yingting Lin, Wang Ye, Guanghui Wang, Xiaobin Li, Haifeng Chen

Journal of Natural Products

DOI

2026

Discovery of Dual-Target Anti-Alzheimer’s Filicinic Acid-Based Meroterpenoids from Hypericum japonicum Thunb.

Shengfei Zhong, 何守伦, Jun Chen, Jingyu Sun, Lulu Fu, Yuxin Lin, Yuhang You, Guanghui Wang, Xiaobin Li, Haifeng Chen, Wenjing Tian

Journal of Natural Products

DOI

2026

Discovery of a novel cinnamoyl piperazinyl alepterolic acid hybrid as a TrxR1 inhibitor for inducing ROS/ER stress-mediated apoptosis in breast cancer

Zi Liu, Xiuping Mao, Xin Jin, Chenlu Xia, Chen Wang, Huajun Zhao, Junfeng Hu, Yong Wu, Guozheng Huang, Haifeng Chen, Liang Ma

European Journal of Medicinal Chemistry

DOI

2026

In Vivo Metabolic Profiling of Equisetum debile Roxb . in Rats Based on High‐Resolution Mass Spectrometry

Chunyan Zhu, Yang Yuexin, Bahriman Xarpidin, Dandan Zhang, Shuhan He, Chenyang Wei, Wenjing Tian, HaiFeng Chen, Caisheng Wu

Biomedical Chromatography

DOI

2025

Tongmaijiangzhi formula and its hypolipidemic compounds attenuate hyperlipidemia and hepatic steatosis via AMPK/NF-κB pathway

Qiannan Xu, Yuexin Yang, Ying‐Jie Chen, Shoulun He, Renjing Yang, Chunyan Zhu, Chun-Chun Du, Dandan Zhang, Guanghui Wang, Yuting Bian, Xi Luo, Caisheng Wu, Wenjing Tian, Haifeng Chen

Journal of Ethnopharmacology

DOI

2025

Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities

Lin Yingting, Ming Peng, Renjing Yang, Guanghui Wang, Junjie Chen, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen

Marine Drugs

DOI

2025

Ingenane Diterpenoids from Euphorbia peplus as Potential New CHK1 Inhibitors That Sensitize Cancer Cells to Chemotherapy

Mi Zhou, Yanlan Yang, Shoulun He, Qiannan Xu, Chunchun Du, Wenjing Tian, Haifeng Chen

Journal of Natural Products

DOI

2025

Agrimonolide exhibits anti-neuroinflammatory potential via TLR4-mediated pathways

Weiling Li, Qian Peng, Ping Sun, Lingyi Xiang, Yangxin Qi, Xiansheng Ye, Yingying Shi, Song Hu, Haifeng Chen, Binlian Sun

Molecular and Cellular Neuroscience

DOI

2025

Euphorbia diterpenoids from Euphorbia peplus possessing anti-Alzheimer's activity via targeting PPARγ and upregulating the level of ABCA1

Yanlan Yang, Shoulun He, Ying‐Ting Lin, Junjie Chen, Renjing Yang, Xueli Li, Jingyu Sun, Guanghui Wang, Wenjing Tian, Haifeng Chen

Phytochemistry

DOI

2025

Seco-Prenylated Butylphloroglucinol Derivatives from Hypericum elodeoides and Their Anti-Alzheimer’s Disease Activities

Wenjing Tian, Shoulun He, Sheng Zhong, Miaoyunhuan Wang, Lin Yingting, Jingyu Sun, Guanghui Wang, Xiaobin Li, Haifeng Chen

Organic Letters

DOI

2025

Efficient NMR spectroscopy approach for the determination of the relative configuration of Δ5,6Δ11,12-jatrophane diterpenes and their chemotherapy sensitization activities

Wenjing Tian, Jie Li, Mi Ζhou, Yanlan Yang, Lin Yingting, Guanghui Wang, Zhiping Zeng, Yuting Bian, Cuiling Sun, Rong Ding, Haifeng Chen

Phytochemistry

DOI

2024

荷叶中生物碱类化合物及其降血脂活性研究

江健，许倩楠，车莉，赖志成，田文静，陈海峰

《中国中药杂志》

2024

Discovery of sesquiterpene from Youngia japonica with antitumor effect

Xiansheng Ye, Kuan Lin, xiaoqing tao, Jinting Shang, Yuran Gui, Shu-Xiu Zhu, Yiyuan Xia, Haifeng Chen, Binlian Sun, Wei Yong Liu, Xiji Shu

Fitoterapia

DOI

2024

Modulation of TNFR 1-Triggered Inflammation and Apoptosis Signals by Jacaranone in Cancer Cells

Jie Liu, Yang Xu, Guobin Xie, Bingjie Geng, Renjing Yang, Wenjing Tian, Haifeng Chen, Guanghui Wang

International Journal of Molecular Sciences

DOI

2024

Hypersine H, One Undescribed Xanthone From the Hypericum elodeoides Choisy With Anti‐Neuroinflammation Activity

Shoulun He, Xiangzhong Liu, Tingjiya Wang, Jingdian Li, Lin Yingting, Mi Ζhou, Cuiling Sun, Rong Ding, Guanghui Wang, Haifeng Chen, Wenjing Tian

Chemistry & Biodiversity

DOI

2024

C‐13 Norisoprenoids and Eudesmanoids from Nelumbo nucifera Gaertn. Regulate the Lipid Metabolism via the AMPK/ACC/SREBP‐1c Signaling Pathway

Jian Wei Jiang, Cuiling Sun, Guanghui Wang, Qiong Xu, Yuting Bian, Jie Li, Jingdian Li, Rong Ding, Hou‐Wen Lin, Wenjing Tian, Haifeng Chen

Chemistry & Biodiversity

DOI

2024

The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system

Xiansheng Ye, Wenjing Tian, Guanghui Wang, Kuan Lin, Shu-Xiu Zhu, Yiyuan Xia, Binlian Sun, Xiji Shu, Wei Liu, Haifeng Chen

Food & medicine homology.

DOI

2024

Four undescribed coumarin derivatives, with ten amides from the roots of Ficus hirta and their cytotoxic activities

Xiansheng Ye, Wenjing Tian, Guanghui Wang, Lijuan Hu, Changlong Leng, Binlian Sun, Wei Liu, Xiji Shu, Haifeng Chen

Bioorganic Chemistry

DOI

2023

Correction: Sun et al. Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice. Molecules 2023, 28, 2406

Ping Sun, Weiling Li, Jiazheng Guo, Qian Peng, Xiansheng Ye, Song Hu, Yuchen Liu, Wei Da Liu, Haifeng Chen, Jialu Qiao, Binlian Sun

Molecules

DOI

2023

Dysambiol, an Anti-inflammatory Secomeroterpenoid from a Dysidea sp. Marine Sponge

Wei‐Hua Jiao, Jia-Xin Li, Hongyan Liu, Xiangchao Luo, Tian‐Yong Hu, Guo‐Hua Shi, Dong-Dong Xie, Haifeng Chen, Bao‐Hui Cheng, Hou‐Wen Lin

Organic Letters

DOI

2023

Apocarotenoids from Equisetum debile Roxb. ex Vaucher regulate the lipid metabolism via the activation of the AMPK/ACC/SREBP-1c signaling pathway

Qiannan Xu, Wenjing Tian, Shoulun He, Mi Zhou, Yue Gao, Xiangzhong Liu, Cuiling Sun, Rong Ding, Guanghui Wang, Haifeng Chen

Bioorganic Chemistry

DOI

2023

Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry

Chenghai Wang, Xiansheng Ye, Chengchao Ding, Mengqi Zhou, Weiling Li, Yuansong Wang, Qiang You, Shan Zong, Qian Peng, Deqiang Duanmu, Haifeng Chen, Binlian Sun, Jialu Qiao

Journal of Agricultural and Food Chemistry

DOI

2023

Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice

Ping Sun, Weiling Li, Jiazheng Guo, Qian Peng, Xiansheng Ye, Song Hu, Yuchen Liu, Wei Da Liu, Haifeng Chen, Jialu Qiao, Binlian Sun

Molecules

DOI

2022

仙鹤草中木脂素类成分的研究

贾自立，田文静，杨任靖，卞玉婷，林挺，陈丽霞，陈海峰

《中国中药杂志》

2022

Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity

Xiangzhong Liu, Mi Ζhou, Shoulun He, Qiannan Xu, Chunchun Du, Honghong Zhu, Ting Lin, Guanghui Wang, Wenjing Tian, Haifeng Chen

Pharmaceuticals

DOI

2022

Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage

Wenjing Tian, Mi Zhou, Daren Qiu, Junjie Chen, Xiangzhong Liu, Jing-Dian Li, Ting Lin, Guanghui Wang, Haifeng Chen

Bioorganic Chemistry

DOI

2022

Tautomeric phytosterols from Vernonia amygdalina Delile and their anti-cervical cancer activity

Xiangzhong Liu, Renjing Yang, Qiannan Xu, Mi Zhou, Jie Feng, Guanghui Wang, Ting Lin, Wenjing Tian, Haifeng Chen

Bioorganic Chemistry

DOI

2022

Bisabolane-type sesquiterpenes from Vernonia amygdalina: Absolute configuration and anti-inflammatory activity

Xiangzhong Liu, Wenjing Tian, Mi Ζhou, Qiannan Xu, Jie Feng, Renjing Yang, Shoulun He, Guanghui Wang, Ting Lin, Haifeng Chen

Phytochemistry

DOI

2022

[Lignans from Agrimonia pilosa].

Zi-Li Jia, Wenjing Tian, Renjing Yang, Yuting Bian, Ting Lin, Li-Xia Chen, Haifeng Chen

PubMed

DOI

2022

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Mei Jiang, Gao Jun, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen

Pharmaceuticals

DOI

2022

Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms

Jie Feng, Fengming He, Yuhui Huang, Mi Zhou, Xiangzhong Liu, Xiansheng Ye, Renjing Yang, Wenjing Tian, Haifeng Chen

Food & Function

DOI

2021

海洋来源药食同源品开发利用研究进展

高玥，许倩楠，蔡明刚，胡贤陈，田文静，陈海峰

《中草药》

2021

Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways

Xiansheng Ye, Wenjing Tian, Mi Ζhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xin‐Sheng Yao, Haifeng Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway

Yanlan Yang, Mi Zhou, Dongni Wang, Xiangzhong Liu, Xiansheng Ye, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen

Journal of Natural Products

DOI

2021

A natural product targets BRD4 to inhibit phase separation and gene transcription

Cong Wang, Huasong Lu, Xiangzhong Liu, Xiang Gao, Wenjing Tian, Haifeng Chen, Yuhua Xue, Qiang Zhou

iScience

DOI

2021

Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response

Xiangzhong Liu, Mi Zhou, Chun-Chun Du, Honghong Zhu, Xi Lu, Shoulun He, Guanghui Wang, Ting Lin, Wenjing Tian, Haifeng Chen

Biomedicines

DOI

2021

A discussion on the affecting factors of the fitting procedures’ reliability in isothermal titration calorimetry analysis

Junjie Chen, Wenjing Tian, Yun Ye, Yingpu Tian, Cuiling Sun, Rong Ding, Haifeng Chen

Archives of Biochemistry and Biophysics

DOI

2021

Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

Chun‐Lan Xie, Duo Zhang, Kaiqiang Guo, Qing‐Xiang Yan, Zheng‐Biao Zou, Zhihui He, Zhen Wu, Xiao-kun Zhang, Haifeng Chen, Xian‐Wen Yang

Chinese Chemical Letters

DOI

2021

Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities

Xiansheng Ye, Wenjing Tian, Xiangzhong Liu, Mi Ζhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xin‐Sheng Yao, Haifeng Chen

Natural Product Research

DOI

2021

Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy

Chun‐Lan Xie, Qingmei Liu, Zhihui He, Yingbao Gai, Zheng‐Biao Zou, Zongze Shao, Guang‐Ming Liu, Haifeng Chen, Xian‐Wen Yang

Bioorganic Chemistry

DOI

2021

Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

Chun‐Lan Xie, Duo Zhang, Ting Lin, Zhihui He, Qing‐Xiang Yan, Qi Cai, Xiao-kun Zhang, Xian‐Wen Yang, Haifeng Chen

Frontiers in Microbiology

DOI

2020

Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4

Xiao‐Yao Wang, Xiansheng Ye, Shuo Gao, Liu Jin-xi, Wenjing Tian, Guanghui Wang, Haifeng Chen, Ting Lin

Fitoterapia

DOI

2020

12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77

Mi Zhou, Bo‐Rong Peng, Wenjing Tian, Jui‐Hsin Su, Guanghui Wang, Ting Lin, Dequan Zeng, Jyh‐Horng Sheu, Haifeng Chen

Marine Drugs

DOI

2020

Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα

Daren Qiu, Mi Ζhou, Xiangzhong Liu, Junjie Chen, Guang-Hui Wang, Ting Lin, Fu-Rong Yu, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen

Bioorganic Chemistry

DOI

2020

A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities

Jie Feng, Danyang Zhao, Qiannan Xu, Xiangzhong Liu, Mi Ζhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen

Natural Product Research

DOI

2020

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER to inhibit RANKL signaling

Keqi Wang, Yongyan Chen, Shuo Gao, Maosi Wang, Mengmeng Ge, Qian Yang, Mingkai Liao, Lin Xu, Junjie Chen, Zhiping Zeng, Haifeng Chen, Xiao-kun Zhang, Ting Lin, Hu Zhou

Acta Pharmaceutica Sinica B

DOI

2020

Phakefustatins A–C: Kynurenine-Bearing Cycloheptapeptides as RXRα Modulators from the Marine Sponge Phakellia fusca

Ying Wu, Hongze Liao, Liyun Liu, Fan Sun, Haifeng Chen, Wei‐Hua Jiao, Hongrui Zhu, Fan Yang, Gang Huang, Dequan Zeng, Mi Zhou, Shuping Wang, Hou‐Wen Lin

Organic Letters

DOI

2020

Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities

Xiansheng Ye, Wenjing Tian, Guanghui Wang, Xian Zhang, Mi Ζhou, Dequan Zeng, Xiangzhong Liu, Xin‐Sheng Yao, Yun‐wu Zhang, Haifeng Chen

Journal of Agricultural and Food Chemistry

DOI

2020

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum

Qiannan Xu, Dan Yan Zhu, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian, Haifeng Chen

Natural Product Research

DOI

2020

Polyphenols from Polygonum cuspidatum Reactivate Latent HIV

Shuiyuan Yang, Wenjing Tian, Zhenrui Pan, Ting Lin, Guanghui Wang, Qiang Zhou, Yuhua Xue, Haifeng Chen

Chemistry of Natural Compounds

DOI

2019

Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage

Daren Qiu, Mi Zhou, Ting Lin, Junjie Chen, Guanghui Wang, Yujie Huang, Xin Jiang, Wenjing Tian, Haifeng Chen

Journal of Natural Products

DOI

2019

Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)-α Pathway

Chun‐Lan Xie, Duo Zhang, Jin‐Mei Xia, Chaochao Hu, Ting Lin, Yu-Kun Lin, Guanghui Wang, Wenjing Tian, Zengpeng Li, Xiao-kun Zhang, Xian‐Wen Yang, Haifeng Chen

Marine Drugs

DOI

2019

Fuscasins A–D, Cycloheptapeptides from the Marine Sponge Phakellia fusca

Ying Wu, Lei Liu, Haifeng Chen, Wei‐Hua Jiao, Fan Sun, Liyun Liu, Hongrui Zhu, Shuping Wang, Hou‐Wen Lin

Journal of Natural Products

DOI

2019

Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice

Yu WU, Wenjing Tian, Shuo Gao, Zu‐Jian Liao, Guanghui Wang, Jir‐Mehng Lo, Pei-Hsin LIN, Dequan Zeng, Daren Qiu, Xiangzhong Liu, Mi Zhou, Ting Lin, Haifeng Chen

Chinese Journal of Natural Medicines

DOI

2019

Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1

Shengmei Zhang, Feirong Huang, Wenjin Tian, Jiashuang Lai, Lixia Qian, Wanjin Hong, Haifeng Chen, Liangcheng Li

Biochemical Pharmacology

DOI

2019

Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα

Daren Qiu, Mi Zhou, Junjie Chen, Guanghui Wang, Ting Lin, Yujie Huang, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian, Haifeng Chen

Phytochemistry

DOI

2019

Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis

Chun‐Lan Xie, Jin‐Mei Xia, Ting Lin, Ying-Jie Lin, Yu-Kun Lin, Man‐li Xia, Haifeng Chen, Zhu-Hua Luo, Zongze Shao, Xian‐Wen Yang

Frontiers in Chemistry

DOI

2019

Septosones A–C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa

Yu‐Han Gui, Wei‐Hua Jiao, Mi Zhou, Yun Liang Zhang, Dequan Zeng, Hongrui Zhu, Kechun Liu, Fan Sun, Haifeng Chen, Hou‐Wen Lin

Organic Letters

DOI

2018

Cytoskyrin C, an unusual asymmetric bisanthraquinone with cage-like skeleton from the endophytic fungus Diaporthe sp.

Wenjing Tian, Zu‐Jian Liao, Mi Ζhou, Guanghui Wang, Yu Wu, Shuo Gao, Daren Qiu, Xiangzhong Liu, Ting Lin, Haifeng Chen

Fitoterapia

DOI

2018

Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina

Xiangzhong Liu, Wenjing Tian, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin, Haifeng Chen

Phytochemistry

DOI

2018

[Determination of three anthroic acids in petri dish cultured Antrodia camphorate by quantitative analysis of multi-component with single marker].

Yu Wu, Wenjing Tian, Pei-Xin Lin, Ji-Meng Luo, Ting Lin, Haifeng Chen

PubMed

DOI

2018

Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXRα transcriptional regulation

Wei-Xiang Lin, Chun‐Lan Xie, Mi Zhou, Man‐li Xia, Tingting Zhou, Haifeng Chen, Xian‐Wen Yang, Quan Yang

Natural Product Research

DOI

2018

Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

Siwen Niu, Ning Wang, Chun‐Lan Xie, Zuowang Fan, Zhu-Hua Luo, Haifeng Chen, Xian‐Wen Yang

The Journal of Antibiotics

DOI

2018

A New Xanthone from an Endophytic Fungus of Anoectochilus roxburghii

Zu‐Jian Liao, Wenjing Tian, Xiaoxuan Liu, Xin Jiang, Yu Wu, Ting Lin, Haifeng Chen

Chemistry of Natural Compounds

DOI

2018

Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer

Lianyu Chen, Chien‐shan Cheng, Huifeng Gao, Ling Zhan, Fengjiao Wang, Chao Qu, Ye Li, Peng Wang, Hao Chen, Zhiqiang Meng, Luming Liu, Haifeng Chen, Zhen Chen

Evidence-based Complementary and Alternative Medicine

DOI

2017

C-glycosides from the stems ofCalophyllum membranaceum

Lingjuan Zhu, Sen Yi, Xue Li, Haifeng Chen, Meng Ming, Xue Zhang, Xin‐Sheng Yao

Journal of Asian Natural Products Research

DOI

2017

[Chemical constituents from root of Angelica decursiva].

Zhi-Chao Liao, Xin Jiang, Wenjing Tian, Ting Lin, Haifeng Chen

PubMed

DOI

2017

Alisol A 24-Acetate and Alisol B 23-Acetate Induced Autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells

Chunfei Wang, Liang Feng, Liang Ma, Haifeng Chen, Xiaobin Tan, Xuefeng Hou, Jie Song, Li Cui, Dan Liu, Juan Chen, Nan Yang, Jing Wang, Ying Liu, Bingjie Zhao, Gang Wang, Yuanli Zhou, Xiaobin Jia

Frontiers in Pharmacology

DOI

2017

Norsampsone E, an unprecedented decarbonyl polycyclic polyprenylated acylphloroglucinol with a homoadamantyl core from Hypericum sampsonii

Wenjing Tian, Yu-Qin Qiu, Junjie Chen, Xiaojun Yao, Xiaojun Yao, Guang-Hui Wang, Yi Dai, Haifeng Chen, Xin‐Sheng Yao, Xin‐Sheng Yao

RSC Advances

DOI

2016

泽泻醇提物对大鼠肾毒性及其分子机制的探究实验

汪春飞，马良，侯雪峰，陈海峰，封亮，贾晓斌

《中国中药杂志》

2016

Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii

Wenjing Tian, Yu-Qin Qiu, Haifeng Chen, Xiaojie Jin, Xiaojun Yao, Xiaojun Yao, Y Dai, Xin‐Sheng Yao, Xin‐Sheng Yao

Fitoterapia

DOI

2016

Study on nephrotoxicity of ethanol extract from Alismatis Rhizoma in rats and its molecular mechanism

Chunfei Wang, Liang Ma, Xuefeng Hou, Haifeng Chen, Liang Feng, Xiao‐Bin Jia

China Journal of Chinese Materia Medica

DOI

2016

Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with quadrupole time‐of‐flight tandem mass spectrometry

Zifei Qin, Pei Lin, Yi Dai, Zhihong Yao, Li Wang, Xin‐Sheng Yao, Liyin Liu, Haifeng Chen

Journal of Separation Science

DOI

2016

Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

Wenjing Tian, Yu-Qin Qiu, Xiaojie Jin, Haifeng Chen, Xiaojun Yao, Xiaojun Yao, Yi Dai, Xin‐Sheng Yao, Xin‐Sheng Yao

RSC Advances

DOI

2015

RXRα transcriptional inhibitors from the stems of Calophyllum membranaceum

Meng Ming, Xue Zhang, Haifeng Chen, Lingjuan Zhu, Dequan Zeng, Jian Yang, Guang-Xun Wu, Yuzhuo Wu, Xin‐Sheng Yao

Fitoterapia

DOI

2015

Study on chemical profiles and metabolites of Allii Macrostemonis Bulbus as well as its representative steroidal saponins in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Zifei Qin, Yi Dai, Zhihong Yao, Liangliang He, Qiyi Wang, Jianliang Geng, Haifeng Chen, Xin‐Sheng Yao

Food Chemistry

DOI

2015

Cytotoxic metabolites from Botryotinia fuckeliana A-S-3: An endophytic fungus from Ajuga decumbens

Ting Lin, Guanghui Wang, Dequan Zeng, Haifeng Chen

Phytochemistry Letters

DOI

2015

Bioactive prenylated xanthones from the stems ofCratoxylum cochinchinense

Yinghui Duan, Yi Dai, Guanghui Wang, Liuyuan Chen, Haifeng Chen, Dequan Zeng, Yao-Lan Li, Xin‐Sheng Yao

Journal of Asian Natural Products Research

DOI

2015

Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses

Rongli Zhang, Shila Gilbert, Xin‐Sheng Yao, Jefferson E. Vallance, Kris A. Steinbrecher, Richard Moriggl, Dongsheng Zhang, Madhu Eluri, Haifeng Chen, Huiqing Cao, Noah F. Shroyer, Lee A. Denson, Xiaonan Han

Pharmacology Research & Perspectives

DOI

2015

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

Jin Hu, Ting Lin, Yuehong Gao, Junyue Xu, Chao Jiang, Guanghui Wang, Guojun Bu, Huaxi Xu, Haifeng Chen, Yun‐wu Zhang

PLoS ONE

DOI

2014

小槐花大极性部位的化学成分研究

朱丹，王帝，王光辉，郭志坚，邹秀红，林挺，陈海峰

《中国中药杂志》

2014

Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens

Ting Lin, Guanghui Wang, Wenjun Shan, Dequan Zeng, Rong Ding, Xin Jiang, Dan Zhu, Xiaoxuan Liu, Shuiyuan Yang, Haifeng Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2014

Total synthesis and RXRα-mediated transcription studies of neriifolone B and related compounds

Qirong Shen, Yi Dai, Guanghui Wang, Fei Yao, Yinghui Duan, Haifeng Chen, Weige Zhang, Xiao-kun Zhang, Xin‐Sheng Yao

Bioorganic & Medicinal Chemistry

DOI

2014

U12, a UDCA Derivative, Acts as an Anti-Hepatoma Drug Lead and Inhibits the mTOR/S6K1 and Cyclin/CDK Complex Pathways

Yang Xu, Qiang Luo, Ting Lin, Zhiping Zeng, Guanghui Wang, Dequan Zeng, Rong Ding, Cuiling Sun, Xiao-kun Zhang, Haifeng Chen

PLoS ONE

DOI

2014

Dioxasampsones A and B, Two Polycyclic Polyprenylated Acylphloroglucinols with Unusual Epoxy-Ring-Fused Skeleton from Hypericum sampsonii

Wenjing Tian, Yu-Qin Qiu, Xiaojun Yao, Xiaojun Yao, Haifeng Chen, Yi Dai, Xiao-kun Zhang, Xin‐Sheng Yao, Xin‐Sheng Yao

Organic Letters

DOI

2014

Quantification and visualization of glutathione S-transferase omega 1 in cells using inductively coupled plasma mass spectrometry (ICP-MS) and fluorescence microscopy

Yong Liang, Xin Jiang, Nannan Tang, Limin Yang, Haifeng Chen, Qiuquan Wang

Analytical and Bioanalytical Chemistry

DOI

2014

ChemInform Abstract: Myrotheciumones: Bicyclic Cytotoxic Lactones Isolated from an Endophytic Fungus of Ajuga decumbens.

Ting Lin, Guanghui Wang, Wenjun Shan, Dequan Zeng, Rong Ding, Xin Jiang, Dan Zhu, Xiaoxuan Liu, Shuiyuan Yang, Haifeng Chen

ChemInform

DOI

2014

Novel polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

Wenjing Tian, Yu-Qin Qiu, Xiaojie Jin, Haifeng Chen, Xiaojun Yao, Xiaojun Yao, Yi Dai, Xin‐Sheng Yao, Xin‐Sheng Yao

Tetrahedron

DOI

2014

Norsampsones A–D, Four New Decarbonyl Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii

Wenjing Tian, Yang Yu, Xiaojun Yao, Xiaojun Yao, Haifeng Chen, Yi Dai, Xiao-kun Zhang, Xin‐Sheng Yao, Xin‐Sheng Yao

Organic Letters

DOI

2014

Structure Elucidation and Biological Activity of Two New Trichothecenes from an Endophyte, Myrothecium roridum

Ting Lin, Guanghui Wang, Yuqi Zhou, Dequan Zeng, Xiaoxuan Liu, Rong Ding, Xin Peng Jiang, Dan Zhu, Wenjun Shan, Haifeng Chen

Journal of Agricultural and Food Chemistry

DOI

2013

Antiproliferative Cardiac Glycosides from the Latex of Antiaris toxicaria

Qian Liu, Jinshan Tang, Mengjie Hu, Jie Liu, Haifeng Chen, Hao Gao, Guanghui Wang, Shun‐Lin Li, Xiao‐Jiang Hao, Xiao-kun Zhang, Xin‐Sheng Yao

Journal of Natural Products

DOI

2012

A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Guanghui Wang, Xiaoyu Guo, Haifeng Chen, Ting Lin, Yang Xu, Quancheng Chen, Jie Liu, Jin-Zhang Zeng, Xiao-kun Zhang, Xin‐Sheng Yao

Bioorganic & Medicinal Chemistry Letters

DOI

2012

Targeting Truncated Retinoid X Receptor-α by CF31 Induces TNF-α–Dependent Apoptosis

Guanghui Wang, Fuquan Jiang, Yinghui Duan, Zhiping Zeng, Fan Chen, Yi Dai, Jiebo Chen, Jin‐Xing Liu, Jie Liu, Hu Zhou, Haifeng Chen, Jin-Zhang Zeng, Ying Su, Xin‐Sheng Yao, Xiao-kun Zhang

Cancer Research

DOI

2012

Integrin-Targeted Trifunctional Probe for Cancer Cells: A “Seeing and Counting” Approach

Zhubao Zhang, Qiang Luo, Xiaowen Yan, Zhaoxin Li, Yacui Luo, Limin Yang, Bo Zhang, Haifeng Chen, Qiuquan Wang

Analytical Chemistry

DOI

2012

Europium‐Labeled Activity‐Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS

Xiaowen Yan, Yacui Luo, Zhubao Zhang, Zhaoxin Li, Qiang Luo, Limin Yang, Bo Zhang, Haifeng Chen, Peiming Bai, Qiuquan Wang

Angewandte Chemie International Edition

DOI

2012

Inhibition of Platelet Activation and Aggregation by Furostanol Saponins Isolated From the Bulbs of Allium macrostemon Bunge

Wenchao Ou, Yun Zhong, Benrong Liu, Shiming Liu, Haifeng Chen, Keji Chen

The American Journal of the Medical Sciences

DOI

2011

Structural modification of ginsenoside Rh2 by fatty acid esterification and its detoxification property in antitumor

Gong-Qing Wei, Yinan Zheng, Wei Li, Wencong Liu, Ting Lin, Weiyun Zhang, Haifeng Chen, Jin-Zhang Zeng, Xiao-kun Zhang, Quancheng Chen

Bioorganic & Medicinal Chemistry Letters

DOI

2011

Furocoumarin Derivatives from Radix Angelicae Dahuricae and Their Effects on RXRα Transcriptional Regulation

Dongping Liu, Qiang Luo, Guanghui Wang, Yang Xu, Xiao-kun Zhang, Quancheng Chen, Haifeng Chen

Molecules

DOI

2011

Xanthone and Benzophenone Glycosides from the Stems of Cratoxylum formosum ssp. pruniflorum

Yinghui Duan, Yi Dai, Guanghui Wang, Haifeng Chen, Hao Gao, Jiebo Chen, Xin‐Sheng Yao, Xiao-kun Zhang

Chemical and Pharmaceutical Bulletin

DOI

2010

New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets

Haifeng Chen, Wenchao Ou, Guanghui Wang, Naili Wang, Linnan Zhang, Xin‐Sheng Yao

Molecules

DOI

2009

几种天然植物中抗肿瘤药物的研究进展

范良华，陈海峰，陈思静

《大众科技》

2009

Protobioside抑制肿瘤细胞增殖作用的机制研究

王光辉，陈海峰，王乃利，姚新生

《中国中药杂志》

2009

Two New Steroidal Saponins from Allium macrostemon Bunge and Their Cytotoxity on Different Cancer Cell Lines

Haifeng Chen, Guanghui Wang, Qiang Luo, Naili Wang, Xin‐Sheng Yao

Molecules

DOI

2008

Four new biflavonoids from Selaginella uncinata and their anti-anoxic effect

Junxia Zheng, Naili Wang, Hongwei Liu, Haifeng Chen, Mingming Li, Liying Wu, Ming Fan, Xin‐Sheng Yao

Journal of Asian Natural Products Research

DOI

2000

皂甙的三维定量构效关系研究

谷妍，陈敏伯，董喜城，陈海峰，曾宝珊，冯传莉，俞飙，惠永正

《化学学报》

精选作品

期刊论文

一种靶向核受体RXRα-自噬通路的天然化合物的抗肿瘤作用机制研究

Spiro-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum monogynum and Their anti-Alzheimer’s Disease Effects

Discovery of Dual-Target Anti-Alzheimer’s Filicinic Acid-Based Meroterpenoids from Hypericum japonicum Thunb.

Discovery of a novel cinnamoyl piperazinyl alepterolic acid hybrid as a TrxR1 inhibitor for inducing ROS/ER stress-mediated apoptosis in breast cancer

In Vivo Metabolic Profiling of Equisetum debile Roxb . in Rats Based on High‐Resolution Mass Spectrometry

Tongmaijiangzhi formula and its hypolipidemic compounds attenuate hyperlipidemia and hepatic steatosis via AMPK/NF-κB pathway

Synthesis and Biological Evaluation of Marine-Inspired Benzothiazole Derivatives as Retinoid X Receptor-α Antagonists with Anti-Cancer Activities

Ingenane Diterpenoids from Euphorbia peplus as Potential New CHK1 Inhibitors That Sensitize Cancer Cells to Chemotherapy

Agrimonolide exhibits anti-neuroinflammatory potential via TLR4-mediated pathways

Euphorbia diterpenoids from Euphorbia peplus possessing anti-Alzheimer's activity via targeting PPARγ and upregulating the level of ABCA1

Seco-Prenylated Butylphloroglucinol Derivatives from Hypericum elodeoides and Their Anti-Alzheimer’s Disease Activities

Efficient NMR spectroscopy approach for the determination of the relative configuration of Δ5,6Δ11,12-jatrophane diterpenes and their chemotherapy sensitization activities

荷叶中生物碱类化合物及其降血脂活性研究

Discovery of sesquiterpene from Youngia japonica with antitumor effect

Modulation of TNFR 1-Triggered Inflammation and Apoptosis Signals by Jacaranone in Cancer Cells

Hypersine H, One Undescribed Xanthone From the Hypericum elodeoides Choisy With Anti‐Neuroinflammation Activity

C‐13 Norisoprenoids and Eudesmanoids from Nelumbo nucifera Gaertn. Regulate the Lipid Metabolism via the AMPK/ACC/SREBP‐1c Signaling Pathway

The food and medicine homologous Chinese Medicine from Leguminosae species: A comprehensive review on bioactive constituents with neuroprotective effects on nervous system

Four undescribed coumarin derivatives, with ten amides from the roots of Ficus hirta and their cytotoxic activities

Correction: Sun et al. Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice. Molecules 2023, 28, 2406

Dysambiol, an Anti-inflammatory Secomeroterpenoid from a Dysidea sp. Marine Sponge

Apocarotenoids from Equisetum debile Roxb. ex Vaucher regulate the lipid metabolism via the activation of the AMPK/ACC/SREBP-1c signaling pathway

Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry

Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice

仙鹤草中木脂素类成分的研究

Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity

Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage

Tautomeric phytosterols from Vernonia amygdalina Delile and their anti-cervical cancer activity

Bisabolane-type sesquiterpenes from Vernonia amygdalina: Absolute configuration and anti-inflammatory activity

[Lignans from Agrimonia pilosa].

Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway

Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms

海洋来源药食同源品开发利用研究进展

Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways

Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway

A natural product targets BRD4 to inhibit phase separation and gene transcription

Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response

A discussion on the affecting factors of the fitting procedures’ reliability in isothermal titration calorimetry analysis

Meroterpenthiazole A, a unique meroterpenoid from the deep-sea-derived Penicillium allii-sativi, significantly inhibited retinoid X receptor (RXR)-α transcriptional effect

Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities

Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy

Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi

Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4

12-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77

Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα

A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER to inhibit RANKL signaling

Phakefustatins A–C: Kynurenine-Bearing Cycloheptapeptides as RXRα Modulators from the Marine Sponge Phakellia fusca

Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities

Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum

Polyphenols from Polygonum cuspidatum Reactivate Latent HIV

Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage

Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)-α Pathway

Fuscasins A–D, Cycloheptapeptides from the Marine Sponge Phakellia fusca

Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice

Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1

Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα

Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis

Septosones A–C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa

Cytoskyrin C, an unusual asymmetric bisanthraquinone with cage-like skeleton from the endophytic fungus Diaporthe sp.

Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina

[Determination of three anthroic acids in petri dish cultured Antrodia camphorate by quantitative analysis of multi-component with single marker].

Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXRα transcriptional regulation

Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475

A New Xanthone from an Endophytic Fungus of Anoectochilus roxburghii

Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer

C-glycosides from the stems ofCalophyllum membranaceum

[Chemical constituents from root of Angelica decursiva].

Alisol A 24-Acetate and Alisol B 23-Acetate Induced Autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells

Norsampsone E, an unprecedented decarbonyl polycyclic polyprenylated acylphloroglucinol with a homoadamantyl core from Hypericum sampsonii

泽泻醇提物对大鼠肾毒性及其分子机制的探究实验

Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii

Study on nephrotoxicity of ethanol extract from Alismatis Rhizoma in rats and its molecular mechanism

Quantification and semiquantification of multiple representative components for the holistic quality control of Allii Macrostemonis Bulbus by ultra high performance liquid chromatography with quadrupole time‐of‐flight tandem mass spectrometry

Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii

RXRα transcriptional inhibitors from the stems of Calophyllum membranaceum

Study on chemical profiles and metabolites of Allii Macrostemonis Bulbus as well as its representative steroidal saponins in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Cytotoxic metabolites from Botryotinia fuckeliana A-S-3: An endophytic fungus from Ajuga decumbens