辛宏｜复旦大学｜学者主页

2026

TRIM21 inhibition alleviates acute kidney injury by promoting INTS3-associated DNA damage repair

Xinyi Dong, Shaoyong Zhuang, Jianing Zhang, Zhilong Zhao, Xia Sheng, Yan Li, Xuemei Zhang, Xiaoli Xie, Hong Xin

APOPTOSIS

2026

Impaired BCAA Catabolism Drives Peritoneal Fibrosis via BCKA-Mediated Suppression of the Pentose Phosphate Pathway

Jiayang Li, Tiangang Wu, Junhao Dai, Xin Zhao, Svetlana N. Reilly, Xin Liu, Dongliang Zhang, Hong Xin, Nan Zhu, Zhiping Li, Zanzhe Yu, Xuemei Zhang

Journal of the American Society of Nephrology

DOI

2026

Arginine protects against colonic barrier injury induced by long-term peritoneal dialysis

Junhao Dai, Yu Zhang, Jiaqi He, Feng Li, Hong Xin, Xuemei Zhang, Hui Yan, Yinhang Wang

Scientific Reports

DOI

2025

TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1

Peng Li, Xinyi Dong, XU Lijun, Xuetao Hu, Xiangyu Meng, Peng Yang, Xuemei Zhang, Wei‐Xing Zong, Shenglan Gao, Shaoyong Zhuang, Hong Xin

Biochemical Pharmacology

DOI

2025

Synthetic NKG2D receptor (SNR) armored CAR-T cells overcome antigen heterogeneity of solid tumor

Minmin Sun, Linke Bian, Hongye Wang, Xin Liu, Yantao Li, Zhaorong Wu, Shuangshuang Zhang, Ruidong Hao, Hong Xin, Bo Zhai, Xuemei Zhang, Yuanguo Cheng

Cellular Oncology

DOI

2025

Correction: Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis

Mengling Wang, Feng Zeng, Fengling Ning, Yinhang Wang, Shilin Zhou, Jiaqi He, Cong Li, Cong Wang, Xiaolin Sun, Dongliang Zhang, Jisheng Xiao, Ping Hu, Svetlana N. Reilly, Hong Xin, Xudong Xu, Xuemei Zhang

Journal of Nanobiotechnology

DOI

2024

药理学实验指导

辛宏

《复旦大学出版社有限公司》

2023

TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC

Ning Huang, Peng Li, Xiaolin Sun, Tong Li, Xinyi Dong, Xuemei Zhang, Jifeng Duan, Xia Sheng, Hong Xin

npj Breast Cancer

DOI

2023

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury

Xiaolin Sun, Ning Huang, Peng Li, Xinyi Dong, Jiahong Yang, Xuemei Zhang, Wei‐Xing Zong, Shenglan Gao, Hong Xin

Life Sciences

DOI

2023

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Shilin Zhou, Zanzhe Yu, Zihui Chen, Fengling Ning, Xuetao Hu, Tiangang Wu, Mingxue Li, Hong Xin, Svetlana N. Reilly, Xuemei Zhang

Frontiers in Pharmacology

DOI

2023

Role of organellar Ca2+-activated K+ channels in disease development

Lan Jiang, Jiawei Li, Svetlana N. Reilly, Xin Hong, Nan Guo, Xuemei Zhang

Life Sciences

DOI

2022

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

Ning Huang, Xiao-Lin Sun, Peng Li, Xin Liu, Xue-Mei Zhang, Qian Chen, Hong Xin

Experimental Hematology & Oncology

DOI

2022

Entacapone alleviates acute kidney injury by inhibiting ferroptosis

Jiahong Yang, Xiaolin Sun, Ning Huang, Peng Li, Jiaqi He, Lan Jiang, Xuemei Zhang, Shu Han, Hong Xin

The FASEB Journal

DOI

2022

Emerging role for branched-chain amino acids metabolism in fibrosis

Tiangang Wu, Mengling Wang, Fengling Ning, Shilin Zhou, Xuetao Hu, Hong Xin, Svetlana N. Reilly, Xuemei Zhang

Pharmacological Research

DOI

2022

Astragaloside IV Alleviates Intestinal Barrier Dysfunction via the AKT-GSK3β-β-Catenin Pathway in Peritoneal Dialysis

Jiaqi He, Mengling Wang, Licai Yang, Hong Xin, Fan Bian, Gengru Jiang, Xuemei Zhang

Frontiers in Pharmacology

DOI

2022

Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway

Jia Luo, Juan Wang, Jun Yang, Wenjing Huang, Junqiu Liu, Wenfu Tan, Hong Xin

Journal of Natural Medicines

DOI

2022

Author Correction: Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction

Lei Miao, Xiaoming Xin, Hong Xin, Xiaoyan Shen, Yi Zhun Zhu

Scientific Reports

DOI

2022

Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis

Journal of Nanobiotechnology

DOI

2021

Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling

Fengling Ning, Jie Tao, Dan-dan Li, Lulu Tian, Mengling Wang, Svetlana N. Reilly, Cheng Liu, Hui Cai, Hong Xin, Xuemei Zhang

Acta Pharmacologica Sinica

DOI

2021

A novel role of BK potassium channel activity in preventing the development of kidney fibrosis

Yinhang Wang, Mengling Wang, Fengling Ning, Dadui Ren, Jie Tao, Weiyi Xie, Douglas C. Eaton, Gengru Jiang, Alton B. Farris, Hong Xin, Hui Cai, Xuemei Zhang

Kidney International

DOI

2021

A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities

Xiaopei Cui, Huifeng Jia, Hong Xin, Lei Justan Zhang, Shi Chen, Simin Xia, Xue Li, Wei Xu, Xiaofang Chen, Yujie Feng, Xiaoyue Wei, Haijia Yu, Yanting Wang, Yifan Zhan, Xiangyang Zhu, Xuemei Zhang

Frontiers in Immunology

DOI

2021

BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway

Lan Jiang, Qianhong Yang, Gao Jianjun, Jiahong Yang, Jiaqi He, Hong Xin, Xuemei Zhang

Molecules and Cells

DOI

2020

The influx/efflux mechanisms of d-peptide ligand of nAChRs across the blood–brain barrier and its therapeutic value in treating glioma

Bing Han, Weiyi Xie, Yanxia Zhang, Shilin Zhou, Jiahong Yang, Ruifeng Wang, Yuqing Sun, Xiaoyi Wang, Jie Xu, Dawei Chen, Yinhang Wang, Jiasheng Lu, Fengling Ning, Fu‐Ming Shen, Min Liu, Hui Cai, Hong Xin, Weiyue Lu, Xuemei Zhang

Journal of Controlled Release

DOI

2019

Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest

Qun Wang, Zhi Li Wu, Yuan Xing, Hong yuan Dong, Xin Ping Xu, Hong Xin, Yin hang Wang, Jian bing Zhang, Li Chen, Hui‐Liang Li, Xue Mei Zhang, Wei dong Zhang

Phytomedicine

DOI

2019

Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway

Dadui Ren, Jia Luo, Yingxue Li, Jing Zhang, Jiahong Yang, Junqiu Liu, Xuemei Zhang, Nengneng Cheng, Hong Xin

Phytomedicine

DOI

2019

Structure and function of USP5: Insight into physiological and pathophysiological roles

Fengling Ning, Hong Xin, Junqiu Liu, Chao Lv, Xin Xu, Mengling Wang, Yinhang Wang, Weidong Zhang, Xuemei Zhang

Pharmacological Research

DOI

2019

Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes

Yinhang Wang, Jie Tao, Mengling Wang, Licai Yang, Fengling Ning, Hong Xin, Xudong Xu, Hui Cai, Weiguang Zhang, Ker Yu, Xuemei Zhang

Frontiers in Physiology

DOI

2018

[Effect of licochalcone A on autophagy in renal cell carcinoma via PI3K/Akt/mTOR signaling pathway].

Hong Xin, Wei Xu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

DOI

2018

Current Perspectives on Role of MSC in Renal Pathophysiology

Min Fan, Jing Zhang, Hong Xin, Xiaozhou He, Xuemei Zhang

Frontiers in Physiology

DOI

2017

[Advances in research on regulatory effects of chemical ingredients of traditional Chinese medicine on UDP-glucuronosyltransferase 1A1 expression and activity].

Hong Xin, Wei Xu

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

DOI

2016

Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases.

Hong Xin, Xiao-Yi Qi, Jing-Jing Wu, Xin-Xin Wang, Yan Li, James Y. Hong, Wei He, Wei Xu, Guang-Bo Ge, Ling Yang

Food and Chemical Toxicology

DOI

2016

NADPH oxidase 4 contributes to connective tissue growth factor expression through Smad3-dependent signaling pathway

Xinhua Liu, Qiu-Yan Zhang, Li‐Long Pan, Siyu Liu, Peng Xu, Xiaoling Luo, Sili Zou, Hong Xin, Lefeng Qu, Yi Zhun Zhu

Free Radical Biology and Medicine

DOI

2016

AMPK Serves as a Therapeutic Target Against Anemia of Inflammation

Minjun Wang, Hong Xin, Wenbo Tang, Yiming Li, Zhaoyun Zhang, Linling Fan, Lei Miao, Bo Tan, Xiling Wang, Yi Zhun Zhu

Antioxidants and Redox Signaling

DOI

2016

Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages

Lei Miao, Xiaoyan Shen, Matthew Whiteman, Hong Xin, Yaqi Shen, Xiaoming Xin, Philip Keith Moore, Yi Zhun Zhu

Antioxidants and Redox Signaling

DOI

2016

Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide–Nitric Oxide Hybrid Molecule

Qingxun Hu, Dan Wu, Fenfen Ma, Suna Yang, Bo Tan, Hong Xin, Xianfeng Gu, Xu Chen, Siyao Chen, Yicheng Mao, Yi Zhun Zhu

Antioxidants and Redox Signaling

DOI

2016

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction

Lei Miao, Xiaoming Xin, Hong Xin, Xiaoyan Shen, Yi Zhun Zhu

Scientific Reports

DOI

2015

Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.

Wei He, Jing-Jing Wu, Jing Ning, Jie Hou, Hong Xin, Yu-Qi He, Guang-Bo Ge, Wei Xu

Toxicology in Vitro

DOI

2015

Identification and characterization of human UDP‐glucuronosyltransferases responsible for the in‐vitro glucuronidation of arctigenin

Hong Xin, Yang-Liu Xia, Jie Hou, Ping Wang, Wei He, Ling Yang, Guang-Bo Ge, Wei Xu

The Journal of pharmacy and pharmacology

DOI

2015

Highly Efficient Preparation of Resorufin-β-D-glucuronide†

Xin-Xin Wang, Xia Lu, Guang-Bo Ge, Lei Feng, Hong Xin, Yao-Guang Li, Yun-Feng Cao, G. Han, Bin Guo

DOI

2015

Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation

Hong Xin, Minjun Wang, Wenbo Tang, Zhuqing Shen, Lei Miao, Weijun Wu, Chengyi Li, Xiling Wang, Xiaoming Xin, Yi Zhun Zhu

Antioxidants and Redox Signaling

DOI

2015

Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters

Ying Kong, Yuanqiu Peng, Yuan Liu, Hong Xin, Xia Zhan, Wenfu Tan

Stem Cells

DOI

2015

Induction of Heme Oxygenase-1 by Sodium 9-Hydroxyltanshinone IIA Sulfonate Derivative Contributes to Inhibit LPS-Mediated Inflammatory Response in Macrophages

Xinhua Liu, Xiling Wang, Hong Xin, Dan Wu, Xiaoming Xin, Lei Miao, Qiu-Yan Zhang, Yang Zhou, Qian Liu, Qian Zhang, Yi Zhun Zhu

Cellular Physiology and Biochemistry

DOI

2014

P8 Hydrogen sulfide and SPRC mitigate infarct of myocardial infarction via governing migration and infilitration of macrophages

Lei Miao, Hong Xin, Xiaoming Xin, Yi Zhun Zhu

Nitric Oxide

DOI

2014

P44 H2S down-regulates expression of hepcidin in response to inflammation via inhibition of IL-6/STAT3 and activin B/SMAD1/5/8 pathway

Hong Xin, Minjun Wang, Yi Zhun Zhu

Nitric Oxide

DOI

2014

Establishment and Characterization of 7 Novel Hepatocellular Carcinoma Cell Lines from Patient-Derived Tumor Xenografts

Hong Xin, Ke Wang, Gang Hu, Fubo Xie, Kedong Ouyang, Xuzhen Tang, Minjun Wang, Danyi Wen, Yi Zhun Zhu, Xiaoran Qin

PLoS ONE

DOI

2013

Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

Hong Xin, Ying Kong, Yong Wang, Yingjun Zhou, Yi Zhun Zhu, Dapeng Li, Wenfu Tan

Phytomedicine

DOI

2010

Salidroside Attenuates Apoptosis in Ischemic Cardiomyocytes: a Mechanism Through a Mitochondria-Dependent Pathway

Han Zhong, Hong Xin, Li-Xin Wu, Yi Zhun Zhu

Journal of Pharmacological Sciences

DOI

2010

Neuroprotective Effects of Leonurine on Ischemia/Reperfusion-Induced Mitochondrial Dysfunctions in Rat Cerebral Cortex

Jia Qi, Zhen Yi Hong, Hong Xin, Yi Zhun Zhu

Biological and Pharmaceutical Bulletin

DOI

2009

Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells

Hong Xin, Xin Hua Liu, Yi Zhun Zhu

European Journal of Pharmacology

DOI

2007

Hydrogen sulfide: third gaseous transmitter, but with great pharmacological potential

Changqing Chen, Hong Xin, Yi Zhun Zhu

Acta Pharmacologica Sinica

DOI

精选作品

期刊论文

TRIM21 inhibition alleviates acute kidney injury by promoting INTS3-associated DNA damage repair

Impaired BCAA Catabolism Drives Peritoneal Fibrosis via BCKA-Mediated Suppression of the Pentose Phosphate Pathway

Arginine protects against colonic barrier injury induced by long-term peritoneal dialysis

TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1

Synthetic NKG2D receptor (SNR) armored CAR-T cells overcome antigen heterogeneity of solid tumor

Correction: Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis

药理学实验指导

TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC

TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Role of organellar Ca2+-activated K+ channels in disease development

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

Entacapone alleviates acute kidney injury by inhibiting ferroptosis

Emerging role for branched-chain amino acids metabolism in fibrosis

Astragaloside IV Alleviates Intestinal Barrier Dysfunction via the AKT-GSK3β-β-Catenin Pathway in Peritoneal Dialysis

Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway

Author Correction: Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction

Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis

Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling

A novel role of BK potassium channel activity in preventing the development of kidney fibrosis

A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities

BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway

The influx/efflux mechanisms of d-peptide ligand of nAChRs across the blood–brain barrier and its therapeutic value in treating glioma

Bilobetin induces kidney injury by influencing cGMP-mediated AQP-2 trafficking and podocyte cell cycle arrest

Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway

Structure and function of USP5: Insight into physiological and pathophysiological roles

Mechanism of Regulation of Big-Conductance Ca2+-Activated K+ Channels by mTOR Complex 2 in Podocytes

[Effect of licochalcone A on autophagy in renal cell carcinoma via PI3K/Akt/mTOR signaling pathway].

Current Perspectives on Role of MSC in Renal Pathophysiology

[Advances in research on regulatory effects of chemical ingredients of traditional Chinese medicine on UDP-glucuronosyltransferase 1A1 expression and activity].

Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases.

NADPH oxidase 4 contributes to connective tissue growth factor expression through Smad3-dependent signaling pathway

AMPK Serves as a Therapeutic Target Against Anemia of Inflammation

Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages

Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide–Nitric Oxide Hybrid Molecule

Hydrogen Sulfide Recruits Macrophage Migration by Integrin β1-Src-FAK/Pyk2-Rac Pathway in Myocardial Infarction

Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice.

Identification and characterization of human UDP‐glucuronosyltransferases responsible for the in‐vitro glucuronidation of arctigenin

Highly Efficient Preparation of Resorufin-β-D-glucuronide†

Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation

Twist1 and Snail Link Hedgehog Signaling to Tumor-Initiating Cell-Like Properties and Acquired Chemoresistance Independently of ABC Transporters

Induction of Heme Oxygenase-1 by Sodium 9-Hydroxyltanshinone IIA Sulfonate Derivative Contributes to Inhibit LPS-Mediated Inflammatory Response in Macrophages

P8 Hydrogen sulfide and SPRC mitigate infarct of myocardial infarction via governing migration and infilitration of macrophages

P44 H2S down-regulates expression of hepcidin in response to inflammation via inhibition of IL-6/STAT3 and activin B/SMAD1/5/8 pathway

Establishment and Characterization of 7 Novel Hepatocellular Carcinoma Cell Lines from Patient-Derived Tumor Xenografts

Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

Salidroside Attenuates Apoptosis in Ischemic Cardiomyocytes: a Mechanism Through a Mitochondria-Dependent Pathway

Neuroprotective Effects of Leonurine on Ischemia/Reperfusion-Induced Mitochondrial Dysfunctions in Rat Cerebral Cortex

Herba leonurine attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells

Hydrogen sulfide: third gaseous transmitter, but with great pharmacological potential

研究方向