邱志霞｜中国药科大学｜学者主页

2026

SLC13A5驱动的代谢-炎症轴在代谢性疾病、癌症及神经系统疾病中的作用及研究进展

李艳珍，张仔翊，胡文俊，陶奕同，邱志霞

《中国药科大学学报》

2026

LC-MS/MS法测定小型猪血浆中泰妙菌素浓度及其在不同制剂药代动力学研究中的应用

涂佳卉，耿梅，侯庆明，罗贤海，邱志霞，王聪

《中国药科大学学报》

2026

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity.

Xu-Hong Li, Yan Liang, Xiao-Yu Zhang, Yong-Sheng Wu, Ti-Zhi Wu, Yu-Cheng Tian, Cheng Tang, Zhixia Qiu, Hongxi Wu, Jin-Lei Bian, Zhi-Yu Li, Xi Xu, Ju-Bo Wang

Future Medicinal Chemistry

DOI

2026

DB-2B, a Novel and Selective STAT3 Inhibitor Inhibits Colorectal Cancer Progression In Vitro and In Vivo

Yu-Ting Chen, Dian-Yang Li, Meng-Di Zhang, Zhixia Qiu, Hong-He Zhang, Wenying Yu, Zhi-Yong Liang, Mao-De Lai

Biomolecules

DOI

2026

Discovery of YYSW001: A Highly Selective, Orally Bioavailable JAK1 Inhibitor Achieving Efficacy under a Moderate-Inhibition Strategy with Improved Preclinical Tolerability.

Kaiyong Hu, Ye-Zhi Wang, Pengfei Xu, Tian Jing, Xinying Cheng, Pei-De Shen, Bao-Xi Wang, Kang Fu, Min Zhang, Ming Gao, Zhi-Yu Li, Ju-Bo Wang, Zhixia Qiu, Jin-Lei Bian

Journal of Medicinal Chemistry

DOI

2025

催化酰胺类药物水解代谢酶的研究进展

王誉晓，王新鸿，王丽梅，邱志霞

《中国药科大学学报》

2025

Dual inhibition of hepatic ACLY and ACSS2: a synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement.

Meng-Di Zhang, Jinliang Ji, Yuan-Yuan Lei, Fujian Qin, Yitong Tao, Ning Li, Jin-Lei Bian, Zhiyu Li, Maode Lai, Zhixia Qiu

Pharmacological Research

DOI

2025

Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders.

Zhi-Sheng Zhang, Xuan Zhang, Ti-Zhi Wu, Sheng-Nan Shi, Jiahui Tu, Man-Qi Zhang, Yan Liang, Mengyan Ma, Sai Zhang, Guangyue Gong, Bing Huang, Ahmed R. Ali, Zhixia Qiu, Jin-Lei Bian, Hongxi Wu, Zhi-Yu Li, Xi Xu, Ju-Bo Wang

European journal of medicinal chemistry

DOI

2025

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Li'ao Zhang, Bao Xue, Mingkang Cao, Yuhan Mao, Feihai Ma, Limei Wang, Xiaolei Yang, Xin-Yi Zhao, Zhixia Qiu, Jielin Tang, Min Guo, Jin-Lei Bian, Xin-Wen Chen, Zhi-Yu Li, Xi Xu, Qi Yang

Journal of Medicinal Chemistry

DOI

2025

Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders.

Yanqing Zhang, Wenjing Liu, Chao Tong, Xinhong Wang, Xiujin Chang, Fangui Qu, Zhiming Zhang, Zhongpeng Fan, Monong Zhao, Cheng Tang, Beichen Song, M. Ding, Zhixia Qiu, Ju-Bo Wang, Jin-Lei Bian, Zhi-Yu Li, Hongxi Wu, Xi Xu

Journal of Medicinal Chemistry

DOI

2025

A polyene macrolide targeting phospholipids in the fungal cell membrane

Qisen Deng, Yinchuan Li, Wen-Yan He, Tao Chen, Nan Liu, Ling-Man Ma, Zhixia Qiu, Zhuo Shang, Zongqiang Wang

Nature

DOI

2025

Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment.

Qiushuang Sun, Huan Chen, Qianqian Lin, Yan-Yi Wu, Yuan-Yuan Lei, Xianhai Luo, Ning Li, Luzhou Xu, Sufeng Zhou, Jun Cheng, F. Huang, Zhixia Qiu

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2024

高生物利用度姜黄素对肿瘤坏死因子-α致人脐静脉内皮细胞炎症损伤模型的保护作用

何飞燕，陈欢，邱志霞，金子恒，齐淑贞，黄芳

《安徽中医药大学学报》

2024

Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia.

Li'ao Zhang, Wenjun Hu, Huimin Guo, Qiushuang Sun, Xi Xu, Zhi-Yu Li, Zhixia Qiu, Jin-Lei Bian

Journal of Medicinal Chemistry

DOI

2024

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.

Yong-Qiang Sun, Tianxing Hu, Meng-Di Zhang, Jia-Xing Song, Zhen Qin, Mai Liu, Jinliang Ji, Zhi-Yu Li, Zhixia Qiu, Jin-Lei Bian

Journal of Medicinal Chemistry

DOI

2024

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Jiali Huang, Xiankang Zhang, Hui Zhang, Yu Li, Hui-Dan Huang, Zhi-Yu Li, Zhixia Qiu, Hongxi Wu, Dechun Huang, Xi Xu, Jin-Lei Bian

Advancement of science

DOI

2024

Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.

Lian Qin, Xinying Cheng, Shijiao Wang, Guangyue Gong, Hui-Yan Su, Hui-Dan Huang, Tian Chen, Davaadagva Damdinjav, Buyankhishig Dorjsuren, Zhi-Yu Li, Zhixia Qiu, Jin-Lei Bian

Journal of Medicinal Chemistry

DOI

2023

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy.

Ti-Zhi Wu, Zhiming Zhang, Guangyue Gong, Zekun Du, Yifan Xu, Sixian Yu, Feihai Ma, Xuan Zhang, Yuxiao Wang, Haomin Chen, Shi-Qi Wu, Xi Xu, Zhixia Qiu, Zhi-Yu Li, Hongxi Wu, Jin-Lei Bian, Ju-Bo Wang

European journal of medicinal chemistry

DOI

2023

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer.

Ti-Zhi Wu, Bin Yu, Yifan Xu, Zekun Du, Zhiming Zhang, Yuxiao Wang, Haomin Chen, Li'ao Zhang, Rui Chen, Feihai Ma, Wei Gong, Sixian Yu, Zhixia Qiu, Hongxi Wu, Xi Xu, Ju-Bo Wang, Zhi-Yu Li, Jin-Lei Bian

Journal of Medicinal Chemistry

DOI

2023

Corydalis saxicola Bunting total alkaloids improve NAFLD by suppressing de novo lipogenesis through the AMPK-SREBP1 axis.

Yating Guo, Qiushuang Sun, Shijiao Wang, Meng-Di Zhang, Yuan-Yuan Lei, Jiejie Wu, Xinhong Wang, Wenjun Hu, Hai-Tao Meng, Zhiyu Li, Luzhou Xu, F. Huang, Zhixia Qiu

Journal of Ethnopharmacology

DOI

2023

Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis

Qiushuang Sun, Yating Guo, Wenjun Hu, Mengdi Zhang, Shijiao Wang, Yuanyuan Lei, Haitao Meng, Ning Li, Pengfei Xu, Zhiyu Li, Hai‐Shu Lin, Fang Huang, Zhixia Qiu

Drug Metabolism and Disposition

DOI

2023

Intracellular spatiotemporal metabolism in connection to target engagement

Jingwei Zhang, Zhixia Qiu, Yongjie Jessica Zhang, Guangji Wang, Haiping Hao

Advanced Drug Delivery Reviews

DOI

2023

Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery

Li’ao Zhang, Wenjun Hu, Zhixia Qiu, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2023

Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma

Yu Zhuang, Yuxiao Wang, Ning Li, Haitao Meng, Zhiyu Li, Jian‐Guang Luo, Zhixia Qiu

European Journal of Drug Metabolism and Pharmacokinetics

DOI

2023

Discovery of a photoactivatable dimerized STING agonist based on the benzo[ b ]selenophene scaffold

Dongyu Liu, Bin Yu, Xin Guan, Bin Song, Huikai Pan, Renbing Wang, Xi Feng, Lixia Pan, Huidan Huang, Zhe Wang, Hongxi Wu, Zhixia Qiu, Zhiyu Li, Jinlei Bian

Chemical Science

DOI

2022

肝肠首过效应对五味子醇甲在大鼠体内生物利用度的影响

李宁，沈璐，牛丽君，李卓，邱志霞，张德文

《南京中医药大学学报》

2022

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression

Yucheng Tian, Kang Liu, Ruoyi Liu, Zhixia Qiu, Yifan Xu, Wei Wei, Xi Jin Xu, Jubo Wang, Hong Ding, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2022

Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice

Jiejie Wu, Ping Chen, Linjie Ju, Renhao Gao, Silu Li, Ziqian Huang, Yiqiu Cheng, Shuqi Gui, Zhixia Qiu, Jun Cheng, Fang Huang

Biomedicine & Pharmacotherapy

DOI

2022

Contributions of intestine and liver to the absorption and disposition of FZJ-003, a selective JAK1 inhibitor with structure modification of filgotinib

Yu Zhuang, Qiushuang Sun, Tian Jing, Jia Liu, Haitao Meng, Yaqi Cao, Zhixia Qiu, Junen Sun, Ning Li

European Journal of Pharmaceutical Sciences

DOI

2022

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles

Xi Jin Xu, Xiujin Chang, Jingxuan Huang, Di Zhang, Min Wang, Tian Jing, Yu Zhuang, Junping Kou, Zhixia Qiu, Jubo Wang, Zhiyu Li, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2021

岩黄连总碱药效物质基础及药理作用机制研究进展

郭雅婷，孙秋爽，邱志霞，黄芳

《药学研究》

DOI

2021

岩黄连总碱对代谢相关脂肪性肝病小鼠的治疗作用及分子机制研究

陈萍，鞠霖杰，成俊，刁和芳，赵开军，邱志霞，黄芳

《药物评价研究》

2021

姜黄素改善非酒精性脂肪性肝病的研究进展

孙秋爽，郭雅婷，庄玉，黄芳，邱志霞

《南京中医药大学学报》

DOI

2021

Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway

Chu Biao Xue, Sixue Liu, Jie Hu, Jin Long Huang, Hong‐Min Liu, Zhixia Qiu, Fang Huang

Chinese Medicine

DOI

2021

Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia

Kai Yuan, Minghui Ji, Shengnan Xie, Zhixia Qiu, Weijiao Chen, Wenjian Min, Fei Xia, Mingming Zheng, Xiao Wang, Jiaxing Li, Yi Hou, Wenbin Kuang, Liping Wang, Wanjian Gu, Zhiyu Li, Peng Yang

Journal of Medicinal Chemistry

DOI

2021

Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD

Qiushuang Sun, Qun Niu, Yating Guo, Yu Zhuang, Xiaonan Li, Jia Liu, Ning Li, Zhiyu Li, Fang Huang, Zhixia Qiu

Journal of Agricultural and Food Chemistry

DOI

2021

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site

Xi Jin Xu, Jubo Wang, Min Wang, Xinyu Yuan, Lei Li, Chao Zhang, Huidan Huang, Tian Jing, Chenchen Wang, Chao Tong, Liwen Zhou, Ying Meng, Pengfei Xu, Junping Kou, Zhixia Qiu, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2021

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats

Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang

Frontiers in Pharmacology

DOI

2020

SLC13A5作为代谢性疾病潜在药物作用靶点的研究进展

牛群，孙秋爽，邱志霞，黄芳

《中国药科大学学报》

2020

Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages

Qiu‐Yan Liu, Yu Zhuang, Xianrui Song, Qun Niu, Qiushuang Sun, Xiaonan Li, Ning Li, Baolin Liu, Fang Huang, Zhixia Qiu

Acta Pharmacologica Sinica

DOI

2020

Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

Linjie Ju, Peipei Hu, Ping Chen, Xue Xue, Zhuoqun Li, Feiyan He, Zhixia Qiu, Jun Cheng, Fang Huang

Biomedicine & Pharmacotherapy

DOI

2020

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Pengfei Xu, Hai Wang, Pei Shen, Peng Peng, Yongrui Tu, Yongqiang Sun, Jubo Wang, Chenxi Xu, Zhixia Qiu, Raoling Ge, Zhiyu Li, Jinlei Bian

Organic Process Research & Development

DOI

2020

Systematic analysis and identification of the absorption and metabolic components of Zengye decoction in type 2 diabetic rats by HPLC-ESI-Q-TOF–MS/MS

Shanquan Chang, Mei Wang, Yushan Tian, Jin Qi, Zhixia Qiu

Chinese Medicine

DOI

2019

凝血因子Ⅹa抑制剂专利技术分析

赵冬梅，房长进，邱志霞

《中国药科大学学报》

2019

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity

Xin Chen, Xinyang Chen, Raphael R. Steimbach, Tong Wu, Hongmei Li, Wenjia Dan, Peidong Shi, Chenyu Cao, Ding Li, Aubry K. Miller, Zhixia Qiu, Jin‐Ming Gao, Yong Zhu

European Journal of Medicinal Chemistry

DOI

2019

Liuwei Dihuang Pills alleviate the polycystic ovary syndrome with improved insulin sensitivity through PI3K/Akt signaling pathway

Zhixia Qiu, Jingjing Dong, Chu Biao Xue, Xiaonan Li, Kang Liu, Baolin Liu, Jun Cheng, Fang Huang

Journal of Ethnopharmacology

DOI

2019

Insulin resistance accelerated the clearance of resveratrol: A note of caution

Zhixia Qiu, Qiuyan Liu, Jiaojiao Yu, Yu Dai, Xiaonan Li, Fang Huang, Ning Li

Journal of Functional Foods

DOI

2018

中药学专业药代动力学教学改革探索

邱志霞，宣圆圆，张培培，王晓虎，黄芳

《药学研究》

2018

岩黄连的研究进展

余姣娇，邱志霞，刘秋燕，黄芳

《药学研究》

2018

PEGylated Triacontanol Substantially Enhanced the Pharmacokinetics of Triacontanol in Rats

Ning Li, Xiaoyu Lu, Min Fang, Zhixia Qiu, Xijing Chen, Lili Ren, Pingkai Ouyang, Guoguang Chen

Journal of Agricultural and Food Chemistry

DOI

2018

Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method

Xixiao Wang, Jie Ren, Shixing Zhu, Guoqing Ren, Lei Wang, Xiaoyan Chen, Zhixia Qiu, Chaofeng Zhang

Journal of Pharmaceutical and Biomedical Analysis

DOI

2018

Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats

Jiaojiao Yu, Qiuyan Liu, Xiaoyu Lu, Xiaonan Li, Ning Li, Baolin Liu, Fang Huang, Zhixia Qiu

Phytotherapy Research

DOI

2018

Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations

Yimeng Zhou, Ning Li, Zhixia Qiu, Xiaoyu Lu, Min Fang, Xijing Chen, Lili Ren, Guangji Wang, Pingkai Ouyang

Drug Delivery

DOI

2017

A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

Zhixia Qiu, Jiaojiao Yu, Yu Dai, Yue Yang, Xiaoyu Lu, Jiaqiu Xu, Zhiying Qin, Fang Huang, Ning Li

Biomedical Chromatography

DOI

2017

The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice

Zhixia Qiu, Shuihong Zhang, Aiyun Li, Jiaojiao Yu, Ning Li, Fang Huang, Baolin Liu

Journal of Functional Foods

DOI

2017

A simple LC–MS/MS method for the simultaneous quantification of resveratrol and its major phase II metabolites: Assessment of their urinary and biliary excretions in rats

Zhixia Qiu, Jiaojiao Yu, Yu Dai, Xijing Chen, Fang Huang, Ning Li

Journal of Chromatography B

DOI

2017

Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway

Yan Zan, Cui-Xing Kuai, Zhixia Qiu, Fang Huang

The American Journal of Chinese Medicine

DOI

2016

Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel

Zhixia Qiu, Wenchao Gao, Yu Dai, Sufeng Zhou, Jie Zhao, Yang Lu, Xijing Chen, Ning Li

Frontiers in Pharmacology

DOI

2016

Biotin-Conjugated Multilayer Poly [D,L-lactide-co-glycolide]-Lecithin-Polyethylene Glycol Nanoparticles for Targeted Delivery of Doxorubicin

Yu Dai, Han Xing, Fuling Song, Yue Yang, Zhixia Qiu, Xiaoyu Lu, Qi Liu, Shuangxia Ren, Xijing Chen, Ning Li

Journal of Pharmaceutical Sciences

DOI

2016

The role of metformin and resveratrol in the prevention of hypoxia‐inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue

Xiaole Li, Jia Li, Lulu Wang, Aiyun Li, Zhixia Qiu, Lian‐Wen Qi, Junping Kou, Kang Liu, Baolin Liu, Fang Huang

British Journal of Pharmacology

DOI

2016

Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s

Xiaolin Sun, Junxiu Li, Chaorui Guo, Han Xing, Jie Xu, Yanli Wen, Zhixia Qiu, Qiuyang Zhang, Yi Zheng, Xijing Chen, Di Zhao

Drug Metabolism and Pharmacokinetics

DOI

2015

The Potential Drug-Drug Interactions of Ginkgolide B Mediated by Renal Transporters

Zhixia Qiu, Lei Wang, Yu Dai, Weichao Ren, Wenwen Jiang, Xijing Chen, Ning Li

Phytotherapy Research

DOI

2014

降钙素口服制剂的研究进展

刘琦，邱志霞，戴昱，巫冠中，陈西敬

《中国药房》

2014

HPLC法和生物测定法测定鲑鱼降钙素肠溶胶囊含量的比较

王雪莲，戴昱，杜玖月，邱志霞，刘琦，陈西敬

《中国药房》

2014

Biliary Excretion of Glycyrrhetinic Acid: Glucuronide‐Conjugate Determination Following a Pharmacokinetic Study of Rat Bile

Yang Lu, Jing Jing, Weichao Ren, Jing Zhu, Zhixia Qiu, Ning Li, Xiao‐Nan Li, Di Zhao, Harendra S. Parekh, Xijing Chen

Phytotherapy Research

DOI

2014

Inhibitory Effects of Calf Thymus DNA on Metabolism Activity of CYP450 Enzyme in Human Liver Microsomes

Shuoye Yang, Zhixia Qiu, Qiuyang Zhang, Jiayin Chen, Xijing Chen

Drug Metabolism and Pharmacokinetics

DOI

2013

Pharmacokinetics and Biodistribution Study of Paclitaxel Liposome in Sprague-Dawley Rats and Beagle Dogs by Liquid Chromatography-Tandem Mass Spectrometry

Xin Wang, Ling Song, Ning Li, Zhixia Qiu, Sufeng Zhou, Cuiyun Li, Jie Zhao, H. Song, Xi-Jing Chen

Drug Research

DOI

2011

降钙素的研究进展

侯笑然，张庆，李国坤，邱志霞，陈西敬

《中国药房》

2011

Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes

Tingting Li, Ning Li, Qinglong Guo, Hui Ji, Di Zhao, Shan Xie, Xiao‐Nan Li, Zhixia Qiu, Deen Han, Xijing Chen, Qidong You

European Journal of Drug Metabolism and Pharmacokinetics

DOI

2011

Elucidation of the Structures of Metabolites of Picroside II in Rat Bile by LC–ESI–IT–MS

Tingting Li, Qiaoling Yu, Deen Han, Ying Y. Zhao, Di Zhao, Hui Ji, Xijing Chen, Ning Li, Zhixia Qiu, Yi Zheng

Chromatographia

DOI

2011

Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers

Jiake He, Zhixia Qiu, Ning Li, Yang Yu, Yang Lu, Deen Han, Tingting Li, Di Zhao, Wei Sun, Fang Fang, Jianheng Zheng, Hongwei Fan, Xijing Chen

European Journal of Clinical Pharmacology

DOI

精选作品

期刊论文

SLC13A5驱动的代谢-炎症轴在代谢性疾病、癌症及神经系统疾病中的作用及研究进展

LC-MS/MS法测定小型猪血浆中泰妙菌素浓度及其在不同制剂药代动力学研究中的应用

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity.

DB-2B, a Novel and Selective STAT3 Inhibitor Inhibits Colorectal Cancer Progression In Vitro and In Vivo

Discovery of YYSW001: A Highly Selective, Orally Bioavailable JAK1 Inhibitor Achieving Efficacy under a Moderate-Inhibition Strategy with Improved Preclinical Tolerability.

催化酰胺类药物水解代谢酶的研究进展

Dual inhibition of hepatic ACLY and ACSS2: a synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement.

Design, synthesis, and pharmacological evaluation of novel isoindoline-based HPK1 degraders.

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders.

A polyene macrolide targeting phospholipids in the fungal cell membrane

Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment.

高生物利用度姜黄素对肿瘤坏死因子-α致人脐静脉内皮细胞炎症损伤模型的保护作用

Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia.

Structure-Guided Discovery of Potent and Selective CLK2 Inhibitors for the Treatment of Knee Osteoarthritis.

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Discovery of Novel Aminobutanoic Acid-Based ASCT2 Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy.

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer.

Corydalis saxicola Bunting total alkaloids improve NAFLD by suppressing de novo lipogenesis through the AMPK-SREBP1 axis.

Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis

Intracellular spatiotemporal metabolism in connection to target engagement

Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery

Hydrolytic Metabolism of Withangulatin A Mediated by Serum Albumin Instead of Common Esterases in Plasma

Discovery of a photoactivatable dimerized STING agonist based on the benzo[ b ]selenophene scaffold

肝肠首过效应对五味子醇甲在大鼠体内生物利用度的影响

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression

Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice

Contributions of intestine and liver to the absorption and disposition of FZJ-003, a selective JAK1 inhibitor with structure modification of filgotinib

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles

岩黄连总碱药效物质基础及药理作用机制研究进展

岩黄连总碱对代谢相关脂肪性肝病小鼠的治疗作用及分子机制研究

姜黄素改善非酒精性脂肪性肝病的研究进展

Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway

Discovery of Dual CDK6/PIM1 Inhibitors with a Novel Structure, High Potency, and Favorable Druggability for the Treatment of Acute Myeloid Leukemia

Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site

Corydalis Saxicola Bunting Total Alkaloids Attenuate Walker 256-Induced Bone Pain and Osteoclastogenesis by Suppressing RANKL-Induced NF-κB and c-Fos/NFATc1 Pathways in Rats

SLC13A5作为代谢性疾病潜在药物作用靶点的研究进展

Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages

Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Systematic analysis and identification of the absorption and metabolic components of Zengye decoction in type 2 diabetic rats by HPLC-ESI-Q-TOF–MS/MS

凝血因子Ⅹa抑制剂专利技术分析

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity

Liuwei Dihuang Pills alleviate the polycystic ovary syndrome with improved insulin sensitivity through PI3K/Akt signaling pathway

Insulin resistance accelerated the clearance of resveratrol: A note of caution

中药学专业药代动力学教学改革探索

岩黄连的研究进展

PEGylated Triacontanol Substantially Enhanced the Pharmacokinetics of Triacontanol in Rats

Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method

Inhibitory and inductive effects of Corydalis saxicola Bunting total alkaloids (CSBTA) on cytochrome P450s in rats

Superior anti-neoplastic activities of triacontanol-PEG conjugate: synthesis, characterization and biological evaluations

A simple LC–MS/MS method facilitated by salting‐out assisted liquid–liquid extraction to simultaneously determine trans‐resveratrol and its glucuronide and sulfate conjugates in rat plasma and its application to pharmacokinetic assay

The role of curcumin in disruption of HIF-1α accumulation to alleviate adipose fibrosis via AMPK-mediated mTOR pathway in high-fat diet fed mice

A simple LC–MS/MS method for the simultaneous quantification of resveratrol and its major phase II metabolites: Assessment of their urinary and biliary excretions in rats

Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway

Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel

Biotin-Conjugated Multilayer Poly [D,L-lactide-co-glycolide]-Lecithin-Polyethylene Glycol Nanoparticles for Targeted Delivery of Doxorubicin

The role of metformin and resveratrol in the prevention of hypoxia‐inducible factor 1α accumulation and fibrosis in hypoxic adipose tissue

Pharmacokinetic effects of curcumin on docetaxel mediated by OATP1B1, OATP1B3 and CYP450s

The Potential Drug-Drug Interactions of Ginkgolide B Mediated by Renal Transporters

降钙素口服制剂的研究进展

HPLC法和生物测定法测定鲑鱼降钙素肠溶胶囊含量的比较

Biliary Excretion of Glycyrrhetinic Acid: Glucuronide‐Conjugate Determination Following a Pharmacokinetic Study of Rat Bile

Inhibitory Effects of Calf Thymus DNA on Metabolism Activity of CYP450 Enzyme in Human Liver Microsomes

Pharmacokinetics and Biodistribution Study of Paclitaxel Liposome in Sprague-Dawley Rats and Beagle Dogs by Liquid Chromatography-Tandem Mass Spectrometry

降钙素的研究进展

Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes

Elucidation of the Structures of Metabolites of Picroside II in Rat Bile by LC–ESI–IT–MS

Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers

预印本

Corydalis Saxicola Bunting Total Alkaloids Regulates Bile Acids Metabolism in Hfhfd-Induced Mice Based on the Gut-Liver Axis

Discovery of Novel Thiohydantoin Derivatives as Full Antagonists and Efficient Degraders of Androgen Receptor