周兆才｜复旦大学｜学者主页

2026

Gastric cancer in the Era of neural regulation

Jingwu Yue, Jiao Shi, Zhaocai Zhou

Chinese Journal of Cancer Research

2026

Author Correction: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

S. Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhu-Bing Shi, Yanyan Wang, Xiao-Min Song, Heng Liu, Chun-Yang Li, M. Chen, Wenjia Wang, Yun Zhao, Zheng-Fan Jiang, Hongyan Wang, Catherine C. L. Wong, Chen Wang, Zhaocai Zhou

Nature Immunology

DOI

2026

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou

Advanced Science

DOI

2026

Gastric cancer tertiary lymphoid structures in the muscularis propria are associated with therapy resistance and promote immunosuppression

Yan Meng, Meng Wang, 龙满美, Yantao Duan, Jingwu Yue, Delin Zou, Weihong Zhang, Mingquan Li, Ruixian Yu, Lin Shao, Xinyu Yang, Yi Han, Wenjia Wang, Jianfeng Chen, Miao He, Yang Tang, Zongwei Chen, Wei Kang, Ka Fai To, Zhaocai Zhou, Dazhi Xu, Hui Li, Shi Jiao

Nature Communications

DOI

2026

Neutrophil-intrinsic Vgll4 constrains tumorigenesis by preventing a STAT3/STAT5-driven immunosuppressive switch

Lin Shao, Jingwu Yue, Shilong Wang, Ruixian Yu, Shuting Cheng, Pingping Nie, Xiaoya Jiang, Yi Han, Wenjia Wang, Yan Meng, Moubin Lin, Miao He, Jianfeng Chen, Zhaocai Zhou, Shi Jiao

Proceedings of the National Academy of Sciences

DOI

2026

Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer

YaTing Wen, LingJie Tang, Wenwen Duan, Qingfei Ren, Yangyue Ni, Shiyang Chen, Jun Chen, Jun Chen, Huan Wang, Huan Wang, YunZhe Zheng, YunZhe Zheng, XingChao Pan, Hui Du, Mengwen Huang, An Zeng, Zhaocai Zhou, Zhigang Zhang, Hongbin Ji, Gaoxiang Ge, Yi Arial Zeng, Wei Zhang, Shihui Wang, Jianjun Cheng, Sheng Wang, JianFeng Chen, JianFeng Chen

Cell

DOI

2026

Gastric Cancer: Pathobiology and Therapeutics

Ruixian Yu, Miao Zhang, Yu Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meng Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou

MedComm

DOI

2026

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis

Junping Bai, Dandan Geng, Xinwen Chen, Wanting Li, X L Wang, Luyang Tian, Yi Han, Zhao Jin, Meng Du, Yang Tang, Weisheng Hu, Chunxiao Zhu, S T Zhang, Zhangting Zhao, Run Zhang, Xinru Zhang, Wei Kang, K F To, Sachiyo Nomura, Fenghua Guo, Shi Jiao, Yixuan Xie, Zhaocai Zhou, Chao Dong, Hongli Li, Liwei An

Cell Discovery

DOI

2026

The MST4–14-3-3ζ complex promotes pancreatic cancer by activating YAP

Luyang Tian, Zhangting Zhao, Shisi Ding, M C Li, Yi Han, Chunxiao Zhu, Y T Pan, X L Wang, Wei Kang, Liwei An, Zhaocai Zhou, Yang Tang

Biology Direct

DOI

2025

整合蛋白质组学与单细胞转录组学揭示SERPINB6棕榈酰化修饰促胃癌分子机制

杨婕，白俊平，郭峰华，安利伟，周兆才

《中国细胞生物学学报》

2025

STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

Fuda Xie, Yang Lyu, Bonan Chen, Hoi-Wing Leung, Peiyao Yu, Tiejun Feng, Canbin Fang, Alvin H.K. Cheung, Bin Zhou, Jianhui Jiang, Ge Zhang, Dazhi Xu, Li Liang, Chen Hao Jiang, Jianwu Chen, Zhaocai Zhou, Liwei An, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Kam Tong Leung, Ching Hei To, Brigette B.Y. Ma, Chi Chun Wong, William Ka Kei Wu, Jun Yu, Ka Fai To, Wei Kang

Molecular Cancer

DOI

2025

Author Correction: Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis

Jinsong Wei, Zhifa Cao, Qing Li, Xiaoyu Li, Qingzhe Wang, Yiming Zhang, Run Zhang, Xingru Wu, Quanhui Dai, Xinyang Li, Zhaocai Zhou, Fenyong Sun, Shi Jiao, Bing Tian Zhao

Nature Chemical Biology

DOI

2025

Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis

Jinsong Wei, Zhifa Cao, Qing Li, Xiaoyu Li, Qingzhe Wang, Yiming Zhang, Run Zhang, Xingru Wu, Quanhui Dai, Xinyang Li, Zhaocai Zhou, Fenyong Sun, Shi Jiao, Bing Tian Zhao

Nature Chemical Biology

DOI

2025

Proteasome stress activates YAP/TAZ through the RAP2–MAP4Ks–LATS1/2 pathway and its therapeutic implications in solid tumors

Xin Wang, Yuan Gu, Zhenxing Zhong, Pengcheng Yu, Wenshuai Liu, Rui Zhu, Yu Wang, Zhaocai Zhou, Yihong Sun, Xuefei Wang, Fa‐Xing Yu

Proceedings of the National Academy of Sciences

DOI

2025

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis

Fan Chen, Yi Han, Jingwu Yue, Hui Zhang, Luyang Tian, Zhifa Cao, Mengwen Zhu, Wenjia Wang, Yan Meng, Liwei An, Feng Li, Huanhu Zhang, Wenqi Bai, Yanfeng Xi, Zaisheng Ye, Shi Jiao, Zhaocai Zhou

Cell Reports

DOI

2025

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3

Shiyang Wang, Xi Wu, Wenxin Bi, Jiuzhi Xu, Liyuan Hou, Guilin Li, Yuwei Pan, Hanfu Zhang, Mengzhen Li, Sujuan Du, Mingxin Zhang, Di Liu, Shuiling Jin, Xiaojing Shi, Yuhua Tian, Jianwei Shuai, Maksim V. Plikus, Moshi Song, Zhaocai Zhou, Lu Yu, Cong Lv, Zhengquan Yu

Nature Communications

DOI

2025

YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer

Zhehui Zhu, Rui Ding, Wei Yu, Yun Liu, Zhaocai Zhou, Chen‐Ying Liu

Cell Death and Differentiation

DOI

2024

Modeling human gastric cancers in immunocompetent mice

Weihong Zhang, Shilong Wang, Hui Zhang, Yan Meng, Shi Jiao, Liwei An, Zhaocai Zhou

Cancer Biology and Medicine

DOI

2024

Road of no return — loss of TP53 paves a defined evolution path from gastric preneoplasia-to-cancer

Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou

Cancer Biology and Medicine

DOI

2024

Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity

Zhifa Cao, Yu Hou, Zhangting Zhao, Hui Zhang, Luyang Tian, Yiming Zhang, Chao Dong, Fenghua Guo, Lijie Tan, Yi Han, Wenjia Wang, Shi Jiao, Yang Tang, Liwei An, Zhaocai Zhou

Journal of Biological Chemistry

DOI

2024

Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

Fuping Wen, Yi Han, Hui Zhang, Zhangting Zhao, Wenjia Wang, Fan Chen, Weimin Qin, Junyi Ju, Liwei An, Meng Yan, Jie Yang, Yang Tang, Yun Zhao, Huanhu Zhang, Feng Li, Wenqi Bai, Y-Y Xu, Zhaocai Zhou, Shi Jiao

Nature Communications

DOI

2024

A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis

Yang Tang, Fan Chen, Ge‐Min Fang, Hui Zhang, Yanni Zhang, Hanying Zhu, Xinru Zhang, Yi Han, Zhifa Cao, Fenghua Guo, Wenjia Wang, Dan Ye, Junyi Ju, Lijie Tan, Chuanchuan Li, Yun Zhao, Zhaocai Zhou, Liwei An, Shi Jiao

The EMBO Journal

DOI

2024

Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity

Pingping Nie, Zhifa Cao, Ruixian Yu, Chao Dong, Weihong Zhang, Yan Meng, Hui Zhang, Yu Pan, Zhenzhu Tong, Xiaoya Jiang, Shilong Wang, Mengwen Zhu, Yi Han, Wenjia Wang, Yiming Zhang, Lijie Tan, Chuanchuan Li, Yuanzhi Xu, Liwei An, Bin Li, Shi Jiao, Zhaocai Zhou

Nature Immunology

DOI

2024

The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Junyi Ju, Hui Zhang, Moubin Lin, Zifeng Yan, Liwei An, Zhifa Cao, Dandan Geng, Jingwu Yue, Yang Tang, Luyang Tian, Fan Chen, Yi Han, Wenjia Wang, Shimin Zhao, Shi Jiao, Zhaocai Zhou

Journal of Clinical Investigation

DOI

2023

癌症进化史浅说

安利伟，周兆才

《科学》

2023

The Hippo signaling pathway in gastric cancer

Zhifa Cao, L. An, Yi Han, S. Jiao, Zhaocai Zhou

Acta Biochimica et Biophysica Sinica

DOI

2023

Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6

Yehua Li, Jia-Yin Peng, Yuanxin Xia, Chenyu Pan, Y. Li, Weijie Gu, Jia Wang, Chaoxiong Wang, Yuang Wang, Jiawen Song, Xuan Zhou, Liya Ma, Yiao Jiang, Biao Liu, Q. Feng, Wenjia Wang, S. Jiao, L. An, Dingwen Li, Zhaocai Zhou, Yun Zhao

Theranostics

DOI

2023

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

Jingjing Cao, Li-Li Ji, Yan-Xia Zhan, Xia Shao, Peng-Cheng Xu, Boting Wu, Pu Chen, Luya Cheng, Xi-Bing Zhuang, Yang Ou, Fan-Li Hua, Lihua Sun, Feng Li, Hao Chen, Zhaocai Zhou, Yunfeng Cheng

Cellular & Molecular Immunology

DOI

2023

Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

Jingjing Cao, Li-Li Ji, Yan-Xia Zhan, Xia Shao, Peng-Cheng Xu, Boting Wu, Pu Chen, Luya Cheng, Xi-Bing Zhuang, Yang Ou, Fan-Li Hua, Lihua Sun, Feng Li, Hao Chen, Zhaocai Zhou, Yunfeng Cheng

Cellular & Molecular Immunology

DOI

2023

GPNMB+Gal‐3+ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis

Yan Meng, Qiudong Zhao, Yan Sang, Jianping Liao, Fei Ye, Shuping Qu, Pingping Nie, Liwei An, Weihong Zhang, Shi Jiao, Aimin Huang, Zhaocai Zhou, Lixin Wei

The EMBO Journal

DOI

2023

Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells

Yan Meng, Fei Ye, Pingping Nie, Qiudong Zhao, Liwei An, Wenjia Wang, Shuping Qu, Zhemin Shen, Zhifa Cao, Xiaobing Zhang, Shi Jiao, Dong Wu, Zhaocai Zhou, Lixin Wei

Journal of Hepatology

DOI

2023

Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis

Lichao Zhang, Xiaoqing Lu, Yuanzhi Xu, Xiaoqin La, Jinmiao Tian, Aiping Li, Hanqing Li, Changxin Wu, Yanfeng Xi, Guisheng Song, Zhaocai Zhou, Wenqi Bai, Liwei An, Zhuoyu Li

Cell Death and Disease

DOI

2023

Data from A TNFR2–hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

Yan Meng, Qiudong Zhao, Liwei An, Shi Jiao, Rong Li, Yan Sang, Jianping Liao, Pingping Nie, Fuping Wen, Junyi Ju, Zhaocai Zhou, Lixin Wei

DOI

2022

角鲨烯环氧酶通过积累骨化三醇和激活CYP24A1介导的MAPK信号通路促进结直肠癌细胞增殖

何璐薇，李华光，潘晨宇，华雨桐，彭甲银，周兆才，赵允，林谋斌

《癌症》

2022

胃肠道肿瘤发生及免疫应答的细胞信号机制

张慧，聂平平，焦石，周兆才

《生命的化学》

2022

STRIPAK复合物与肿瘤发生

曹智发，汤扬，聂平平，韩毅，周兆才，安利伟

《中国细胞生物学学报》

2022

A YAP/TAZ-CD54 axis is required for CXCR2−CD44− tumor-specific neutrophils to suppress gastric cancer

Ping-Ping Nie, Weihong Zhang, Yan Meng, Mou-Bin Lin, Feng-Hua Guo, Hui Zhang, Z. Tong, Meng Wang, Fan Chen, L. An, Yang Tang, Yi Han, Rui-Xian Yu, Wenjia Wang, Yuan-Zhi Xu, Linxin Wei, Zhaocai Zhou, S. Jiao

Protein & Cell

DOI

2022

Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers

L. An, Zhifa Cao, Ping-Ping Nie, Hui Zhang, Z. Tong, Fan Chen, Yang Tang, Yi Han, Wenjia Wang, Zhang-Ting Zhao, Qing-Ya Zhao, Yu-Qin Yang, Yuan-Zhi Xu, Ge-Min Fang, Lei Shi, Huixiong Xu, Haiqing Ma, S. Jiao, Zhaocai Zhou

Journal of Clinical Investigation

DOI

2022

Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways

Jinglin Zhang, Bo-Nan Chen, Hui Li, Yifei Wang, Xiao-Li Liu, Kit-Yee Wong, Wai-Nok Chan, A. Chan, A. Cheung, K. Leung, Yu-Juan Dong, Yi-lian Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Jianyong Xiao, C. Wong, W. Wu, Alfred S. L. Cheng, Brigette B. Y. Ma, Jun Yu, Kwok-Wai Lo, Wei Kang, Ka-Fai To

Journal of Pathology

DOI

2022

MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target

Yifei Wang, Hua-Rong Chen, Wei-Xin Liu, Huan Yan, Yihan Zhang, A. Cheung, Jinglin Zhang, Bo-Nan Chen, Li Liang, Zhaocai Zhou, C. Wong, W. Wu, M. Chan, Alfred S. L. Cheng, B. Ma, Jun Yu, Kwok-Wai Lo, Ka-Fai To, Wei Kang

Theranostics

DOI

2022

PAR1 Drives Gastric Carcinogenesis Through Early and Advanced Activation of YAP and Serves as a Therapeutic Target

Huan Yan, Yifei Wang, Bo-Nan Chen, Jinglin Zhang, Yu-Hang Zhou, A. Cheung, Shou-Yu Wang, Bing Huang, Li Liang, Zhaocai Zhou, C. Wong, W. K. Wu, M. Chan, Alfred S. L. Cheng, Jun Yu, Kwok-Wai Lo, Ka-Fai To, Wei Kang

Social Science Research Network

DOI

2022

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis

Yuegui Guo, Zhehui Zhu, Zhenyu Huang, L. Cui, Wei Yu, W. Hong, Zhaocai Zhou, Peng Du, Chen-Ying Liu

Nature Communications

DOI

2021

Decoding the intercellular communication network during tumorigenesis

L. An, Rui-Xian Yu, Yi Han, Zhaocai Zhou

Cancer Biology and Medicine

DOI

2021

Editorial: A Hippo's View: From Molecular Basis to Translational Medicine

Zhaocai Zhou, Zeng-Qiang Yuan, W. Hong, Wenqi Wang

Frontiers in Cell and Developmental Biology

DOI

2021

Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Wen-Jing Zhang, Yijun Gao, Pei-Xue Li, Zhu-Bing Shi, Tong Guo, Fei Li, Xiang-Kun Han, Yan Feng, Chao-Gu Zheng, Zuo-Yun Wang, Fu-Ming Li, Hai-Quan Chen, Zhaocai Zhou, Lei Zhang, H. Ji

Cell Research

DOI

2021

Emc3 maintains intestinal homeostasis by preserving secretory lineages

Mei-Na Huang, Li Yang, Ning Jiang, Quanhui Dai, Run-Sheng Li, Zhaocai Zhou, Bing Zhao, Xinhua Lin

Mucosal Immunology

DOI

2021

A TNFR2–hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

Y. Meng, Qiu-Dong Zhao, L. An, S. Jiao, Rong Li, Yan Sang, Jian-Ping Liao, Ping-Ping Nie, Fuping Wen, Junyi Ju, Zhaocai Zhou, Li-Xin Wei

Cancer Research

DOI

2021

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Hui Zhang, Mou-Bin Lin, Chao Dong, Yang Tang, L. An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, M. Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wen-Bo Bu, Dian-Qing Wu, Lin Li, S. Jiao, Zhaocai Zhou

Advancement of science

DOI

2020

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling

Jiu-Zhi Xu, Yang Tang, Xiao-Le Sheng, Yuhua Tian, Min Deng, Sujuan Du, Cong Lv, Guilin Li, Yu-Wei Pan, Yong-Li Song, Pengbo Lou, Yong-Ting Luo, Yuan Li, Bing-Kun Zhang, Yanmei Chen, Zhanju Liu, Y. Cong, M. Plikus, Q. Meng, Zhaocai Zhou, Zheng-Quan Yu

EMBO Journal

DOI

2020

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.

Yang Tang, Ge-Min Fang, Feng-Hua Guo, Hui Zhang, Xiao-Xu Chen, L. An, M. Chen, Li Zhou, Wenjia Wang, Tian-Tian Ye, Lei Zhou, Ping-Ping Nie, Haijun Yu, Mou-Bin Lin, Yun Zhao, Xinhua Lin, Zeng-Qiang Yuan, S. Jiao, Zhaocai Zhou

Cancer Cell

DOI

2020

Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer.

Guan-Ying Li, Xun-Wu Hu, Ping-Ping Nie, Dingze Mang, S. Jiao, Shi-Jin Zhang, S. Roy, Sachie Yukawa, S. Asahina, Hiroaki Sugasawa, Williams Cortes, Zhaocai Zhou, Ye Zhang

Nano letters (Print)

DOI

2020

MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

L. An, Ping-Ping Nie, M. Chen, Yang Tang, Hui Zhang, Jingmin Guan, Zhifa Cao, Chun Hou, Wenjia Wang, Yun Zhao, Huixiong Xu, S. Jiao, Zhaocai Zhou

Journal of Experimental Medicine

DOI

2019

Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling

Yang Tang, M. Chen, Li Zhou, Jian Ma, Yehua Li, Hui Zhang, Zhu-Bing Shi, Qi Xu, Xiaoman Zhang, Ziyang Gao, Yun Zhao, Yunfeng Cheng, S. Jiao, Zhaocai Zhou

Cell Discovery

DOI

2018

控制肝脏组织发育、再生重塑与大小的关键蛋白质机器

陈兰芬，邓贤明，陈正军，程新，黄晶，姜海，周兆才，丁劲，卫立辛，陈军，赵斌，周大旺

《中国基础科学》

2018

The MST4–MOB4 complex disrupts the MST1–MOB1 complex in the Hippo–YAP pathway and plays a pro-oncogenic role in pancreatic cancer

M. Chen, Hui Zhang, Zhu-Bing Shi, Yehua Li, Xiaoman Zhang, Ziyang Gao, Li Zhou, Jian Ma, Qi Xu, Jingmin Guan, Yunfeng Cheng, S. Jiao, Zhaocai Zhou

Journal of Biological Chemistry

DOI

2018

Targeting IRF3 as a YAP agonist therapy against gastric cancer

S. Jiao, Jingmin Guan, M. Chen, Wenjia Wang, Chuanchuan Li, Yugong Wang, Yunfeng Cheng, Zhaocai Zhou

Journal of Experimental Medicine

DOI

2017

Hippo信号通路结构生物学研究进展

胡立桥，周兆才，田伟

《遗传》

2017

胃肠道肿瘤免疫逃逸

周兆才

《中国免疫学杂志》

2017

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

S. Jiao, Chuanchuan Li, Q. Hao, Haofei Miao, Lei Zhang, Lin Li, Zhaocai Zhou

Nature Communications

DOI

2017

MST kinases in innate immune signaling

Zhu-Bing Shi, Zhaocai Zhou

Cell Stress

DOI

2017

UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing

Chenyu Pan, Yue Xiong, Xiangdong Lv, Yuanxin Xia, Shuo Zhang, Hao Chen, Jialin Fan, Wen-Qing Wu, Feng Liu, Hailong Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao

EMBO Reports

DOI

2016

A positive role for polycomb in transcriptional regulation via H4K20me1

Xiangdong Lv, Zhi-Jun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei, Yun Zhao

Cell Research

DOI

2016

H4K20me1を介した転写調節におけるポリコームの正の役割【Powered by NICT】

Xiangdong Lv, Zhi-Jun Han, Hao Chen, Bo-Kang Yang, Xiaofeng Yang, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Han, Min Wu, Zhaocai Zhou, Lei Zhang, Lin Li, Gang Wei, Yun Zhao

2015

Structural dissection of Hippo signaling.

Zhu-Bing Shi, S. Jiao, Zhaocai Zhou

Acta Biochimica et Biophysica Sinica

DOI

2015

Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling*

Zhu-Bing Shi, Zhen Zhang, Zhenzhen Zhang, Yanyan Wang, Chuanchuan Li, Xin Wang, F. He, Lina Sun, S. Jiao, Wei-Yang Shi, Zhaocai Zhou

Journal of Biological Chemistry

DOI

2015

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

S. Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhu-Bing Shi, Yanyan Wang, Xiao-Min Song, Heng Liu, Chunyang Li, M. Chen, Wenjia Wang, Yun Zhao, Zheng-Fan Jiang, Hongyan Wang, Catherine C. L. Wong, Chen Wang, Zhaocai Zhou

Nature Immunology

DOI

2015

Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila

Hui Han, Chenyu Pan, Chunying Liu, Xiangdong Lv, Xiaofeng Yang, Yue Xiong, Yi Lu, Wen-Qing Wu, Junhai Han, Zhaocai Zhou, Hailu Jiang, Lei Zhang, Yun Zhao

Cell Discovery

DOI

2014

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.

S. Jiao, Huizhen Wang, Zhu-Bing Shi, Aimei Dong, Wen-Jing Zhang, Xiao-Min Song, F. He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Pei-Xue Li, Yun Zhao, H. Ji, Lei Zhang, Zhaocai Zhou

Cancer Cell

DOI

2014

Structural insights into regulatory mechanisms of MO25-mediated kinase activation.

Q. Hao, Miao Feng, Zhu-Bing Shi, Chuanchuan Li, M. Chen, Wenjia Wang, Meng Zhang, S. Jiao, Zhaocai Zhou

Journal of Structural Biology

DOI

2014

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex*

Cui-Cui Chen, Zhu-Bing Shi, Wenqing Zhang, M. Chen, F. He, Zhenzhen Zhang, Yicui Wang, Miao Feng, Wenjia Wang, Yun Zhao, Jerry H. Brown, S. Jiao, Zhaocai Zhou

Journal of Biological Chemistry

DOI

2014

CorrigendumCorrigendum to “Structure of MST2 SARAH domain provides insights into its interaction with RAPL” [J. Struct. Biol. 185 (2014) 366–374]

Guoguang Liu, Zhu-Bing Shi, S. Jiao, Zhenzhen Zhang, Wenjia Wang, Cui-Cui Chen, Q. Hao, Meng Zhang, Miao Feng, Liang Xu, Zhen Zhang, Zhaocai Zhou, M. Zhang

DOI

2014

Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1*

Chuanchuan Li, Miao Feng, Zhu-Bing Shi, Q. Hao, Xiao-Min Song, Wenjia Wang, Yun Zhao, S. Jiao, Zhaocai Zhou

Journal of Biological Chemistry

DOI

2014

The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway*

Feifei Mao, Xiaofeng Yang, Lin Fu, Xiangdong Lv, Zhao Zhang, Wen-Qing Wu, Si-Qi Yang, Zhaocai Zhou, Lei Zhang, Yun Zhao

Journal of Biological Chemistry

DOI

2014

Structure of MST2 SARAH domain provides insights into its interaction with RAPL.

Guoguang Liu, Zhu-Bing Shi, S. Jiao, Zhenzhen Zhang, Wenjia Wang, Cui-Cui Chen, Q. Hao, Meng Zhang, Miao Feng, Liang Xu, Zhen Zhang, Zhaocai Zhou, M. Zhang

Journal of Structural Biology

DOI

2014

VGLL4は,YAP TEAD転写複合体を負に調節することにより肺癌における新しい腫よう抑制因子として機能する

Fei Li, Yan Feng, Tong Guo, Yijun Gao, Fu-Ming Li, Pei-Xue Li, Lei Zhang, Hong-Bing Ji, Chao-Gu Zheng, Zhu-Bing Shi, Zuo-Yun Wang, Xiang-Kun Han, Zhaocai Zhou, Wen-Jing Zhang, Hai-Quan Chen

2014

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Wen-Jing Zhang, Yijun Gao, Pei-Xue Li, Zhu-Bing Shi, Tong Guo, Fei Li, Xiang-Kun Han, Yan Feng, Chao-Gu Zheng, Zuo-Yun Wang, Fu-Ming Li, Hai-Quan Chen, Zhaocai Zhou, Lei Zhang, H. Ji

Cell Research

DOI

2013

Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association

Hongling Huang, Shimin Wang, Meng-Xin Yin, Liang Dong, Chao Wang, Wei Wu, Yi Lu, Miao Feng, Chuanyang Dai, Xiaocan Guo, Li Li, Bin Zhao, Zhaocai Zhou, H. Ji, Jin Jiang, Yun Zhao, Xin-Yuan Liu, Lei Zhang

PLoS Biology

DOI

2013

A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity

Tong Guo, Yi Lu, Pei-Xue Li, Meng-Xin Yin, De-Kang Lv, Wen-Jing Zhang, Huizhen Wang, Zhaocai Zhou, H. Ji, Yun Zhao, Lei Zhang

Cell Research

DOI

2013

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wen-Qing Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao

Journal of Cell Science

DOI

2013

Structure of the MST4 in complex with MO25 provides insights into its activation mechanism.

Zhu-Bing Shi, S. Jiao, Zhen Zhang, M. Ma, Zhao Zhang, Cui Chen, Ke Wang, Huizhen Wang, Wenjia Wang, Lei Zhang, Yun Zhao, Zhaocai Zhou

Structure

DOI

2013

Structural mechanism of CCM3 heterodimerization with GCKIII kinases.

Meng Zhang, Liang Dong, Zhu-Bing Shi, S. Jiao, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cui-Cui Chen, Miao Feng, Q. Hao, Wenjia Wang, Meng-Xin Yin, Yun Zhao, Lei Zhang, Zhaocai Zhou

Structure

DOI

2013

Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction*

Da-Wei Shi, Xiangdong Lv, Zhao Zhang, Xiaofeng Yang, Zhaocai Zhou, Lei Zhang, Yun Zhao

Journal of Biological Chemistry

DOI

2013

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

Xiaofeng Yang, Feifei Mao, Xiangdong Lv, Zhao Zhang, Lin Fu, Yi Lu, Wen-Qing Wu, Zhaocai Zhou, Lei Zhang, Yun Zhao

Development

DOI

2013

Atrophin–Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR

Zhao Zhang, Jing Feng, Chenyu Pan, Xiangdong Lv, Wen-Qing Wu, Zhaocai Zhou, Feng Liu, Lei Zhang, Yun Zhao

Journal of Cell Biology

DOI

2012

Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control*

Yun-Yun Jin, Liang Dong, Yi Lu, Wen-Qing Wu, Q. Hao, Zhaocai Zhou, Jin Jiang, Yun Zhao, Lei Zhang

Journal of Biological Chemistry

DOI

2012

Germinal center kinases in immune regulation

Hailei Yin, Zhu-Bing Shi, S. Jiao, Cui-Cui Chen, Wenjia Wang, M. Greene, Zhaocai Zhou

Cellular & Molecular Immunology

DOI

2012

Multiple Functions of Mammalian Germinal Center Kinases

Hailei Yin, Cui-Cui Chen, Miao Feng, Zhu-Bing Shi, M. Greene, Zhaocai Zhou

DOI

精选作品

期刊论文

Gastric cancer in the Era of neural regulation

Author Correction: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Gastric cancer tertiary lymphoid structures in the muscularis propria are associated with therapy resistance and promote immunosuppression

Neutrophil-intrinsic Vgll4 constrains tumorigenesis by preventing a STAT3/STAT5-driven immunosuppressive switch

Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer

Gastric Cancer: Pathobiology and Therapeutics

TGM2-mediated serotonylation of GPX4 confers ferroptosis resistance to promote gastric tumorigenesis

The MST4–14-3-3ζ complex promotes pancreatic cancer by activating YAP

整合蛋白质组学与单细胞转录组学揭示SERPINB6棕榈酰化修饰促胃癌分子机制

STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

Author Correction: Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis

Nuclear ubiquitination permits Hippo–YAP signal for liver development and tumorigenesis

Proteasome stress activates YAP/TAZ through the RAP2–MAP4Ks–LATS1/2 pathway and its therapeutic implications in solid tumors

Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3

YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer

Modeling human gastric cancers in immunocompetent mice

Road of no return — loss of TP53 paves a defined evolution path from gastric preneoplasia-to-cancer

Reactivating Hippo by drug compounds to suppress gastric cancer and enhance chemotherapy sensitivity

Epstein-Barr virus infection upregulates extracellular OLFM4 to activate YAP signaling during gastric cancer progression

A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis

Targeting p97–Npl4 interaction inhibits tumor Treg cell development to enhance tumor immunity

The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

癌症进化史浅说

The Hippo signaling pathway in gastric cancer

Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6

MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

Author Correction: MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages

GPNMB+Gal‐3+ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis

Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells

Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis

Data from A TNFR2–hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

角鲨烯环氧酶通过积累骨化三醇和激活CYP24A1介导的MAPK信号通路促进结直肠癌细胞增殖

胃肠道肿瘤发生及免疫应答的细胞信号机制

STRIPAK复合物与肿瘤发生

A YAP/TAZ-CD54 axis is required for CXCR2−CD44− tumor-specific neutrophils to suppress gastric cancer

Combinatorial targeting of Hippo-STRIPAK and PARP elicits synthetic lethality in gastrointestinal cancers

Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2–IGF1R and Hippo–YAP1 signaling pathways

MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target

PAR1 Drives Gastric Carcinogenesis Through Early and Advanced Activation of YAP and Serves as a Therapeutic Target

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis

Decoding the intercellular communication network during tumorigenesis

Editorial: A Hippo's View: From Molecular Basis to Translational Medicine

Author Corrections: VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Emc3 maintains intestinal homeostasis by preserving secretory lineages

A TNFR2–hnRNPK Axis Promotes Primary Liver Cancer Development via Activation of YAP Signaling in Hepatic Progenitor Cells

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling

Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer.

Lipid-Raft-Targeted Molecular Self-Assembly Inactivates YAP to Treat Ovarian Cancer.

MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway

Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling

控制肝脏组织发育、再生重塑与大小的关键蛋白质机器

The MST4–MOB4 complex disrupts the MST1–MOB1 complex in the Hippo–YAP pathway and plays a pro-oncogenic role in pancreatic cancer

Targeting IRF3 as a YAP agonist therapy against gastric cancer

Hippo信号通路结构生物学研究进展

胃肠道肿瘤免疫逃逸

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

MST kinases in innate immune signaling

UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing

A positive role for polycomb in transcriptional regulation via H4K20me1

H4K20me1を介した転写調節におけるポリコームの正の役割【Powered by NICT】

Structural dissection of Hippo signaling.

Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling*

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer.

Structural insights into regulatory mechanisms of MO25-mediated kinase activation.

Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex*

CorrigendumCorrigendum to “Structure of MST2 SARAH domain provides insights into its interaction with RAPL” [J. Struct. Biol. 185 (2014) 366–374]

Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1*

The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway*

Structure of MST2 SARAH domain provides insights into its interaction with RAPL.

VGLL4は,YAP TEAD転写複合体を負に調節することにより肺癌における新しい腫よう抑制因子として機能する

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association

A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity