张惠敏｜厦门大学｜学者主页

百晓学者学者目录

精选作品

期刊论文

2026

Temperature-Responsive Agarose-Based Digital Microfluidics: An In-Chip Sample Preparation To Mass Spectrometry Analysis for Trace Cells and Single-Cell Proteomics

Ling Yan, Jiacheng Fang, Huimin Zhang, Yali Lin, Dan Li, Yingyan Zhou, Lin Zhu, Zhi Zhu, Pengyuan Yang, Zongwei Cai

Analytical Chemistry

DOI

2026

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Juan Song, Ying Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong James Yang

Advanced Science

DOI

2026

Dual-Spatially Confined Assembly of DNA Nanowall Stiffens Tumor Cells to Enhance Adoptive T-Cell Immunotherapy

Xiyuan Yu, Min Lyu, Yuanbiao Tu, Yufeng Pei, Yixuan Ke, Ming Zhu, Yilong Liu, He Dong, Zhihui Zhou, Qi Niu, Jie Song, Chaoyong James Yang, Huimin Zhang, Zhi Zhu

Journal of the American Chemical Society

DOI

2025

Enhancing Thermodynamic and Kinetic Performance of Microfluidic Interface-Based Circulating Fetal Cell Isolation for Noninvasive Prenatal Testing

Juan Song, Yuebing Zheng, Xiaodan Huang, Xiyuan Yu, Rui Su, Zhi Zhu, Chaoyong James Yang, Zengpeng Li, Yu Jiang, Huimin Zhang

Analytical Chemistry

DOI

2025

Scalable acoustic virtual stirrer for enhanced interfacial enzymatic nucleic acid reactions

D. M. Li, D. M. Li, Kunjie Li, Jianquan Li, Dongfang Li, Dongfang Li, Heng Chen, Sensen Li, Chaoyong James Yang, Huimin Zhang, Lujian Chen, Xuejia Hu

Science Advances

DOI

2025

Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis

Kunjie Li, Dongbao Tang, Xiaoyun Lu, Xinyao Yang, Luxuan Liu, Zhaoyuan Jia, Zhi Zhu, Yuyu Tan, Huimin Zhang, Chaoyong James Yang

Advanced Science

DOI

2025

Advanced single‐cell RNA sequencing in tumor immunology

Yilong Liu, Xiyuan Yu, Zhipeng Han, Qiuyang Wei, Qi Niu, Chaoyong James Yang, Jie Li, Zijian Guo, Huimin Zhang

Interdisciplinary medicine

DOI

2024

Metabolic Labeling and Digital Microfluidic Single‐Cell Sequencing for Single Bacterial Genotypic‐Phenotypic Analysis

Junnan Guo, Di Sun, Kunjie Li, Qi Dai, Shichen Geng, Yuanyuan Yang, Mengwu Mo, Zhi Zhu, Chen Shao, Wei Wang, Jia Tao Song, Chaoyong James Yang, Huimin Zhang

Small

DOI

2024

Empowering DNA-Based Information Processing: Computation and Data Storage

Kunjie Li, Heng Chen, Dayang Li, Chaoyong James Yang, Huimin Zhang, Zhi Zhu

ACS Applied Materials & Interfaces

DOI

2023

Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics

Shichao Lin, Kun Yin, Yingkun Zhang, Fanghe Lin, Xiaoyong Chen, Xi Zeng, Xiaoxu Guo, Huimin Zhang, Jia Tao Song, Chaoyong James Yang

Nature Communications

DOI

2022

Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy

Shichao Lin, Huajie Ze, Xia‐Guang Zhang, Yue‐Jiao Zhang, Juan Song, Huimin Zhang, Han‐Liang Zhong, Zhi‐Lan Yang, Chaoyong James Yang, Jian‐Feng Li, Zhi Zhu

Angewandte Chemie

DOI

2021

HUNTER-Chip: Bioinspired Hierarchically Aptamer Structure-Based Circulating Fetal Cell Isolation for Non-Invasive Prenatal Testing

Huimin Zhang, Xiyuan Yu, Yilong Liu, Bingqian Lin, Meng Jiang, Juan Song, Wen J. Di, Zhi Zhu, Chaoyong James Yang

Analytical Chemistry

DOI

2021

Microfluidic‐Based Exosome Analysis for Liquid Biopsy

Bingqian Lin, Yan‐Mei Lei, Junxia Wang, Lin Zhu, Yuqi Wu, Huimin Zhang, Lingling Wu, Peng Zhang, Chaoyong James Yang

Small Methods

DOI

2021

Microfluidic single-cell transcriptomics: moving towards multimodal and spatiotemporal omics

Shichao Lin, Yilong Liu, Mingxia Zhang, Xing Jun Xu, Yingwen Chen, Huimin Zhang, Chaoyong James Yang

Lab on a Chip

DOI

2021

Auto-Panning: a highly integrated and automated biopanning platform for peptide screening

Junxia Wang, Jingjing Guo, Kaifeng Zhao, Weidong Ruan, Liang Li, Jiajun Ling, Ruixiao Peng, Huimin Zhang, Chaoyong James Yang, Zhi Zhu

Lab on a Chip

DOI

2021

Stimulus-Responsive Microfluidic Interface Enables Efficient Enrichment and Cytogenetic Profiling of Circulating Myeloma Cells

Yilong Liu, Rui Jun Su, Juan Song, Xiyuan Yu, Shichao Lin, Zhi Zhu, Yuanyuan Yang, Mingxia Zhang, Yang Liu, Huimin Zhang, Xiuqin Xu, Chaoyong James Yang

ACS Applied Materials & Interfaces

DOI

2021

Microfluidic devices with simplified signal readout

Yingzhou Tao, Haicong Shen, Kunyue Deng, Huimin Zhang, Chaoyong James Yang

Sensors and Actuators B Chemical

DOI

2019

基于微流控技术的循环肿瘤细胞分析研究进展

张惠敏，吴玲玲，林冰倩，王奕迪，毕云鹏，王炜，宋彦龄，杨朝勇

《中国科学:化学》

2019

Recent progress on microfluidic technology-based circulating tumor cell analysis

Yidi Wang, Bingqian Lin, Yunpeng Bi, Yanling Song, Huimin Zhang, Lingling Wu, Chaoyong James Yang, Wei Wang

Scientia Sinica Chimica

DOI

2018

Microwell Array Method for Rapid Generation of Uniform Agarose Droplets and Beads for Single Molecule Analysis

Xingrui Li, Dongfeng Zhang, Huimin Zhang, Zhichao Guan, Yanling Song, Ruochen Liu, Zhi Zhu, Chaoyong James Yang

Analytical Chemistry

DOI

2018

Frequency-enhanced transferrin receptor antibody-labelled microfluidic chip (FETAL-Chip) enables efficient enrichment of circulating nucleated red blood cells for non-invasive prenatal diagnosis

Huimin Zhang, Yuanyuan Yang, Xingrui Li, Yuanzhi Shi, Bin Hu, Yuan An, Zhi Zhu, Guolin Hong, Chaoyong James Yang

Lab on a Chip

DOI

2018

Target-responsive DNA hydrogel for non-enzymatic and visual detection of glucose

Yanli Ma, Yu Mao, Yuan An, Tian Tian, Huimin Zhang, Jinmao Yan, Zhi Zhu, Chaoyong James Yang

The Analyst

DOI

2017

Integrating Target-Responsive Hydrogel with Pressuremeter Readout Enables Simple, Sensitive, User-Friendly, Quantitative Point-of-Care Testing

Dan Liu, Shasha Jia, Huimin Zhang, Yanli Ma, Zhichao Guan, Jiuxing Li, Zhi Zhu, Tianhai Ji, Chaoyong James Yang

ACS Applied Materials & Interfaces

DOI

2016

ChemInform Abstract: Recent Progress in Aptamer‐Based Functional Probes for Bioanalysis and Biomedicine

Huimin Zhang, Leiji Zhou, Zhi Zhu, Chaoyong James Yang

ChemInform

DOI

2016

Recent Progress in Aptamer‐Based Functional Probes for Bioanalysis and Biomedicine

Huimin Zhang, Leiji Zhou, Zhi Zhu, Chaoyong James Yang

Chemistry - A European Journal

DOI

2015

Integration of target responsive hydrogel with cascaded enzymatic reactions and microfluidic paper-based analytic devices (µPADs) for point-of-care testing (POCT)

Tian Tian, Xiaofeng Wei, Shasha Jia, Ruihua Zhang, Jiuxing Li, Zhi Zhu, Huimin Zhang, Yanli Ma, Zhenyu Lin, Chaoyong James Yang

Biosensors and Bioelectronics

DOI

2015

A Controllable Aptamer-Based Self-Assembled DNA Dendrimer for High Affinity Targeting, Bioimaging and Drug Delivery

Huimin Zhang, Yanli Ma, Yi Xie, Yuan An, Yishun Huang, Zhi Zhu, Chaoyong James Yang

Scientific Reports

DOI

2015

Design and Synthesis of Target-Responsive Aptamer-Cross-linked Hydrogel for Visual Quantitative Detection of Ochratoxin A

Rudi Liu, Yishun Huang, Yanli Ma, Shasha Jia, Mingxuan Gao, Jiuxing Li, Huimin Zhang, Dunming Xu, Min Wu, Yan Chen, Zhi Zhu, Chaoyong James Yang

ACS Applied Materials & Interfaces

DOI

2014

Au@Pt Nanoparticle Encapsulated Target‐Responsive Hydrogel with Volumetric Bar‐Chart Chip Readout for Quantitative Point‐of‐Care Testing

Zhi Zhu, Zhichao Guan, Shasha Jia, Zhi‐Chao Lei, Shui‐Chao Lin, Huimin Zhang, Yanli Ma, Zhong‐Qun Tian, Chaoyong James Yang

Angewandte Chemie International Edition

DOI

2014

A Cell-Surface-Anchored Ratiometric Fluorescent Probe for Extracellular pH Sensing

Guoliang Ke, Zhi Zhu, Wei Wang, Yuan Wen Zou, Zhichao Guan, Shasha Jia, Huimin Zhang, Xuemeng Wu, Chaoyong James Yang

ACS Applied Materials & Interfaces

DOI

2014

A diazirine-based photoaffinity probe for facile and efficient aptamer–protein covalent conjugation

Huimin Zhang, Yanling Song, Yuan Wen Zou, Yun Ge, Yuan An, Yanli Ma, Zhi Zhu, Chaoyong James Yang

Chemical Communications

DOI

2013

Cyclic enzymatic amplification method (CEAM) based on exonuclease III for highly sensitive bioanalysis

Liang Cui, Guoliang Ke, Xiaoyan Lin, Yanling Song, Huimin Zhang, Zhichao Guan, Zhi Zhu, Chaoyong James Yang

Methods

DOI

2013

ChemInform Abstract: Graphene Oxide Protected Nucleic Acid Probes for Bioanalysis and Biomedicine

Liang Cui, Yanling Song, Guoliang Ke, Zhichao Guan, Huimin Zhang, Ya Lin, Yishun Huang, Zhi Zhu, Chaoyong James Yang

ChemInform

DOI

会议论文

2019

基于多尺度纳米界面的循环胎儿细胞富集微流控芯片的构建及应用

张惠敏，王奕迪，杨朝勇

《第十一届全国化学生物学学术会议》

DOI

2019

基于仿生多价核酸适体功能化微流控芯片的微小残留病检测新方法

刘艺龙，张惠敏，朱志，吕哲豪，王思力，杨朝勇

《第十一届全国化学生物学学术会议论文摘要（第三卷）》

DOI

2019

基于多尺度纳米界面的循环胎儿细胞富集微流控芯片的构建及应用

张惠敏，杨朝勇

《中国化学会第十二届全国微全分析系统学术会议、第七届全国微纳尺度生物分离分析学术会议、第七届国际微流控学学术论坛、The 11th International Symposium on Microchemistry and Microsystems摘要集》

DOI

2018

基于胎儿细胞富集的无创产前诊断新方法

张惠敏，杨园园，杨朝勇

《中国化学会第十三届全国分析化学年会论文集（二）》

DOI

研究方向

高通量单细胞测序空间转录组、表观组学测序微流控技术在生物医学中的应用

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