王文新｜安徽理工大学｜学者主页

2026

From Flory Theory to Real Systems: Decoding Polymerization Deviations in Poly(β-amino ester)s (PAEs)

Yinghao Li, Jing Lyu, Wenxin Wang

Macromolecules

DOI

2026

A thiol-rich immunomodulatory injectable hydrogel suppresses endometrial fibrosis to restore fertilization

Mingwei Li, Runqi Zhu, Yufeng Tian, Hanqing Yu, Liu Yang, Lucy Boyi Wang, Ping Zhou, Qiang Li, Rijian Song, Wenxin Wang

Science Advances

DOI

2026

Near-Infrared Fluorescent Highly Branched Poly(β-Amino Ester)s Nanoparticles for Gene Delivery: In vivo Biodistribution and Safety Evaluation

Hongzhen Zhang, Jiahao Liu, Rui Huang, Ailin Hu, Rui Miao, Guang Chen, Haonan Li, Wenxin Wang, Zhonglei He

International Journal of Nanomedicine

DOI

2026

Cationic injectable hydrogels for wet-tissue sealing with enhanced red blood cell retention

Chunyu Zhao, Hanqing Yu, Jing Lyu, Josie Ward, Lucy Boyi Wang, Qiang Geng, Yuxin Jin, Runqi Zhu, Yufeng Tian, Javier Maisueche, Caiqi Shen, Rijian Song, Wenxin Wang

Chemical Communications

DOI

2026

An Overlooked Formulation Variable: Solvent Reshapes DNA Delivery

Yinghao Li, Bei Qiu, Liang Yao, Jiahao Liu, Zhenghao Li, Xinhui Wang, Jing Lyu, Wenxin Wang

ACS Macro Letters

DOI

2026

Concentration of DNA at the Cell Surface Dictates Transfection Efficacy: A Hyperbranched Poly(β-Amino Ester) Mediated Strategy for Enhanced Lentivirus Production

Miao Wei, Liang Yao, Xingyue Wang, Meilin Guo, Haonan Li, Guang Chen, Xianqing Wang, Xi Wang, Wenxin Wang, Zhonglei He

Polymers

DOI

2026

Tough Injectable Hydrogels Enabled by Integrating Rigid Homogeneous Framework With Flexible Chains

Rijian Song, Runqi Zhu, Cameron Milne, Melissa Johnson, Chunyu Zhao, Qiang Geng, Yinghao Li, Jing Lyu, Qiang Li, A Sigen, Wenxin Wang

Advanced Functional Materials

DOI

2025

Reconfigurable and Chemically Recyclable Thermosets via Cooperative Sulfhydryl–Disulfide Exchange in Sulfur-Rich Dynamic Networks

Wenxin Wang, Wang Li, Xinru Guo, Zhiwen Song, Hui Wang, Yu-Jun Cheng, Liang Shen, Fei Gao

ACS Applied Polymer Materials

DOI

2025

Corrigendum to “Neurotransmitter-endcapped poly(β-amino estate) for enhanced DNA delivery to the brain through intravenous injection” [International Journal of Biological Macromolecules, Volume 322, Part 1, September 2025, 146660]

Rui Huang, Sebnem Gunes, Yinghao Li, Jiahao Liu, Rui Miao, Zihan Zhang, Ben Newland, Wenxin Wang, Zhonglei He

International Journal of Biological Macromolecules

DOI

2025

Cyclization in Linear Step-Growth Polymerizations

Yinghao Li, Jing Lyu, Wenxin Wang

Macromolecules

DOI

2025

Neurotransmitter-endcapped poly(β-amino estate) for enhanced DNA delivery to the brain through intravenous injection

Rui Huang, Sebnem Gunes, Yinghao Li, Jiahao Liu, Rui Miao, Zihan Zhang, Ben Newland, Wenxin Wang, Zhonglei He

International Journal of Biological Macromolecules

DOI

2025

Precise control of branch unit location and its impact on gene delivery

Yinghao Li, Bei Qiu, Liang Yao, Jiajia Wei, Tianyu Mao, Mingzhi Yu, Xinhui Wang, Antonio Benedetto, Zidan Zhang, Jing Lyu, Wenxin Wang

Chemical Engineering Journal

DOI

2025

Synergistic Effect of Guanidinium and Tertiary Amine Groups on Boosting Gene Delivery

Yinghao Li, Jiahao Liu, Liang Yao, Tianyu Mao, Xinyue Wang, Zhonglei He, Jing Lyu, Wenxin Wang

JACS Au

DOI

2025

MSC-derived exosomes injectable hyaluronic acid hydrogel for enhanced chronic wound healing

Hanqing Yu, Jingyu Zhang, Yang Liu, Yu-feng Tian, Cameron Milne, Peisheng Jin, Qiang Li, Rijian Song, Wenxin Wang

Journal of Controlled Release

DOI

2025

Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease

Bei Qiu, Yinghao Li, Zhonglei He, Zishan Li, Sébastien Terreau, Xianqing Wang, Jing Lyu, Wenxin Wang, Irene Lara‐Sáez

Drug Development and Industrial Pharmacy

DOI

2024

In Situ Forming Hypoxia‐Induced Exosome‐Loaded Hydrogel for Enhanced Diabetic Wound Healing

Yongfei Wang, Gang Zhao, A Sigen, Qian Xu, Xiaoli Wu, Wenxin Wang, Yongjun Rui

Macromolecular Materials and Engineering

DOI

2024

An injectable, self-healing, polysaccharide-based antioxidative hydrogel for wound healing

Melissa Johnson, Rijian Song, Yinghao Li, Cameron Milne, Zishan Li, Jing Lyu, A Sigen, Wenxin Wang

RSC Applied Polymers

DOI

2024

Adeno‐associated virus vectors for gene therapy—focusing on melanoma

Xingyue Wang, Miao Wei, Rui Miao, Xiujing Hao, Min Li, Wenxin Wang, Zhonglei He

Interdisciplinary medicine

DOI

2024

Highly branched poly β-amino ester/CpG-depleted CFTR plasmid nanoparticles for non-viral gene therapy in lung cystic fibrosis disease

Bei Qiu, Darío Manzanares, Yinghao Li, Xianqing Wang, Zishan Li, Sébastien Terreau, Zhonglei He, Jing Lyu, Wenxin Wang, Irene Lara‐Sáez

Molecular Therapy — Methods & Clinical Development

DOI

2024

Hyaluronic Acid/Chondroitin Sulfate-Based Dynamic Thiol–Aldehyde Addition Hydrogel: An Injectable, Self-Healing, On-Demand Dissolution Wound Dressing

Melissa Johnson, Rijian Song, Yinghao Li, Cameron Milne, Jing Lyu, Irene Lara‐Sáez, A Sigen, Wenxin Wang

Materials

DOI

2024

Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives

Cameron Milne, Rijian Song, Melissa Johnson, Chunyu Zhao, Francesca Santoro Ferrer, A Sigen, Jing Lyu, Wenxin Wang

Biomacromolecules

DOI

2024

Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion‐Adhesion Balance

Rijian Song, Xiaoyu Wang, Melissa Johnson, Cameron Milne, Anna Lesniak‐Podsiadlo, Yinghao Li, Jing Lyu, Zishan Li, Chunyu Zhao, Lizhu Yang, Irene Lara‐Sáez, A Sigen, Wenxin Wang

Advanced Functional Materials

DOI

2024

Backbone cationized highly branched poly(β-amino ester)s as enhanced delivery vectors in non-viral gene therapy

Yinghao Li, Bei Qiu, Zishan Li, Xianqing Wang, Zhonglei He, Darío Manzanares, Rijian Song, A Sigen, Chunyu Zhao, Melissa Johnson, Jing Lyu, Irene Lara‐Sáez, Wenxin Wang

Journal of Controlled Release

DOI

2024

Fast one-step acrylate functionalization of hyaluronic acid via Williamson ether synthesis

Cameron Milne, Rijian Song, Runqi Zhu, Melissa Johnson, Chunyu Zhao, Francesca Santoro Ferrer, A Sigen, Jing Lyu, Wenxin Wang

Chemical Communications

DOI

2023

Well‐defined poly(N,N‐dimethylacrylamide) from a fast Cu(0)‐mediated reversible‐deactivation radical polymerization in water

Zishan Li, Jing Lyu, Bei Qiu, Melissa Johnson, Chunyu Zhao, Yinghao Li, Qiang Geng, Rijian Song, Liang Yao, Wenxin Wang

Journal of Polymer Science

DOI

2023

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

Zishan Li, Jing Lyu, Bei Qiu, Yinghao Li, Ruth Foley, Rijian Song, Melissa Johnson, Qiang Geng, Wenxin Wang

Chinese Journal of Polymer Science

DOI

2023

Controlled Polymerization of Acrylamide via One-Pot and One-Step Aqueous Cu(0)-Mediated Reversible-Deactivation Radical Polymerization

Zishan Li, Jing Lyu, Yinghao Li, Bei Qiu, Melissa Johnson, Hongyun Tai, Wenxin Wang

Macromolecules

DOI

2023

CRISPR-Cas9-based non-viral gene editing therapy for topical treatment of recessive dystrophic epidermolysis bullosa

Xianqing Wang, Xi Wang, Yinghao Li, A Sigen, Bei Qiu, Albina Bushmalyova, Zhonglei He, Wenxin Wang, Irene Lara‐Sáez

Molecular Therapy — Methods & Clinical Development

DOI

2023

Guanidyl-Rich Poly(β Amino Ester)s for Universal Functional Cytosolic Protein Delivery and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Cas9 Ribonucleoprotein Based Gene Editing

Xianqing Wang, Xianqing Wang, Yinghao Li, Xi Wang, Xi Wang, Darío Manzanares, Zhonglei He, A Sigen, Irene Lara‐Sáez, Wenxin Wang

ACS Nano

DOI

2023

3D Macrocyclic Structure Boosted Gene Delivery: Multi-Cyclic Poly(β-Amino Ester)s from Step Growth Polymerization

Yinghao Li, Xianqing Wang, Zhonglei He, Melissa Johnson, A Sigen, Irene Lara‐Sáez, Jing Lyu, Wenxin Wang

Journal of the American Chemical Society

DOI

2023

Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD)

Yinghao Li, Zhonglei He, A Sigen, Xianqing Wang, Zishan Li, Melissa Johnson, Ruth Foley, Irene Lara‐Sáez, Jing Lyu, Wenxin Wang

ACS Applied Materials & Interfaces

DOI

2023

Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process

Jing Zhang, Zhonglei He, Yinghao Li, Yu Shen, Guanfu Wu, Laura Power, Rijian Song, Ming Zeng, Xianqing Wang, Irene Lara‐Sáez, A Sigen, Qian Xu, James F. Curtin, Ziyi Yu, Wenxin Wang

Acta Biomaterialia

DOI

2022

Modelling Development in Radical (Co)Polymerization of Multivinyl Monomers

Jing Lyu, Yinghao Li, Zishan Li, Piotr Polanowski, Jeremiasz K. Jeszka, Krzysztof Aleksander Matyjaszewski, Wenxin Wang

Angewandte Chemie

DOI

2017

单链超内环化聚合物与线性高分子共混物的黏弹性研究

李思蓉，郭琳茹，高永胜，周德重，王文新

《高分子学报》

2000

分形理论在聚合物共混物界面研究中的应用

王文新，董伯儒，颜德岳

《高分子材料科学与工程》

2000

在共混物界面研究中分数维的物理意义

王文新，董伯儒，颜德岳

《高分子材料科学与工程》

1999

过氧化苯甲酰引发剂存在下的反原子转移自由基聚合(英文)

王文新，涂文平，张宾，颜德岳，邰红云

《合成橡胶工业》

1998

普通自由基引发剂存在下的原子转移自由基聚合(英文)

王文新，颜德岳，邰红云，夏平

《合成橡胶工业》

1998

聚苯乙烯/高密度聚乙烯反应共混的研究

王文新，周持兴，顾再春

《高分子材料科学与工程》

精选作品

期刊论文

From Flory Theory to Real Systems: Decoding Polymerization Deviations in Poly(β-amino ester)s (PAEs)

A thiol-rich immunomodulatory injectable hydrogel suppresses endometrial fibrosis to restore fertilization

Near-Infrared Fluorescent Highly Branched Poly(β-Amino Ester)s Nanoparticles for Gene Delivery: In vivo Biodistribution and Safety Evaluation

Cationic injectable hydrogels for wet-tissue sealing with enhanced red blood cell retention

An Overlooked Formulation Variable: Solvent Reshapes DNA Delivery

Concentration of DNA at the Cell Surface Dictates Transfection Efficacy: A Hyperbranched Poly(β-Amino Ester) Mediated Strategy for Enhanced Lentivirus Production

Tough Injectable Hydrogels Enabled by Integrating Rigid Homogeneous Framework With Flexible Chains

Reconfigurable and Chemically Recyclable Thermosets via Cooperative Sulfhydryl–Disulfide Exchange in Sulfur-Rich Dynamic Networks

Corrigendum to “Neurotransmitter-endcapped poly(β-amino estate) for enhanced DNA delivery to the brain through intravenous injection” [International Journal of Biological Macromolecules, Volume 322, Part 1, September 2025, 146660]

Cyclization in Linear Step-Growth Polymerizations

Neurotransmitter-endcapped poly(β-amino estate) for enhanced DNA delivery to the brain through intravenous injection

Precise control of branch unit location and its impact on gene delivery

Synergistic Effect of Guanidinium and Tertiary Amine Groups on Boosting Gene Delivery

MSC-derived exosomes injectable hyaluronic acid hydrogel for enhanced chronic wound healing

Formulate a concentrated highly branched poly(β-amino ester)/DNA polyplex – one step closer to application in lung cystic fibrosis disease

In Situ Forming Hypoxia‐Induced Exosome‐Loaded Hydrogel for Enhanced Diabetic Wound Healing

An injectable, self-healing, polysaccharide-based antioxidative hydrogel for wound healing

Adeno‐associated virus vectors for gene therapy—focusing on melanoma

Highly branched poly β-amino ester/CpG-depleted CFTR plasmid nanoparticles for non-viral gene therapy in lung cystic fibrosis disease

Hyaluronic Acid/Chondroitin Sulfate-Based Dynamic Thiol–Aldehyde Addition Hydrogel: An Injectable, Self-Healing, On-Demand Dissolution Wound Dressing

Dual-Modified Hyaluronic Acid for Tunable Double Cross-Linked Hydrogel Adhesives

Enhanced Strength for Double Network Hydrogel Adhesive Through Cohesion‐Adhesion Balance

Backbone cationized highly branched poly(β-amino ester)s as enhanced delivery vectors in non-viral gene therapy

Fast one-step acrylate functionalization of hyaluronic acid via Williamson ether synthesis

Well‐defined poly(N,N‐dimethylacrylamide) from a fast Cu(0)‐mediated reversible‐deactivation radical polymerization in water

One-pot and One-step Cu(0)-mediated Reversible-Deactivation Radical Polymerization of N-Isopropylacrylamide (NIPAM) in Water

Controlled Polymerization of Acrylamide via One-Pot and One-Step Aqueous Cu(0)-Mediated Reversible-Deactivation Radical Polymerization

CRISPR-Cas9-based non-viral gene editing therapy for topical treatment of recessive dystrophic epidermolysis bullosa

Guanidyl-Rich Poly(β Amino Ester)s for Universal Functional Cytosolic Protein Delivery and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) Cas9 Ribonucleoprotein Based Gene Editing

3D Macrocyclic Structure Boosted Gene Delivery: Multi-Cyclic Poly(β-Amino Ester)s from Step Growth Polymerization

Artificial Intelligence (AI)-Aided Structure Optimization for Enhanced Gene Delivery: The Effect of the Polymer Component Distribution (PCD)

Enhanced gene transfection efficacy and safety through granular hydrogel mediated gene delivery process

Modelling Development in Radical (Co)Polymerization of Multivinyl Monomers

单链超内环化聚合物与线性高分子共混物的黏弹性研究

分形理论在聚合物共混物界面研究中的应用

在共混物界面研究中分数维的物理意义

过氧化苯甲酰引发剂存在下的反原子转移自由基聚合(英文)

普通自由基引发剂存在下的原子转移自由基聚合(英文)

聚苯乙烯/高密度聚乙烯反应共混的研究

研究方向