林欣｜清华大学｜学者主页

2026

The cGAS-STING pathway in cancer: friend or foe

Qian Li, Qingkang Song, Ling-li Ma, Kuan Kang, Xiaoru Zhu, Yuan Li, Xin Lin, XingXing Lu, Zhao-Yang Zeng, Gui-Yuan Li, Wei Xiong, Bo Xiang, Pan Chen, Mei Yi

Cell Death and Disease

DOI

2026

Abstract 4006: Iterative engineering of GPC-3 targeted synthetic TCR and antigen receptor (STAR) cells in advanced solid tumors

Chang-Song Qi, Jia-Rui Li, Chang Liu, Hong-Li Zheng, Dong-bi Yang, Dan Liu, Pan-Pan Zhang, Miao Zhang, Ran Xue, J. Gong, Lian Liu, Min Tao, Siyuan Cheng, Jian Li, Xiao-Tian Zhang, Jin-Xiang Yin, Xue-Qiang Zhao, Xin Lin, Lin Shen

Cancer Research

DOI

2026

Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia

Meng Lv, Hong-Li Zheng, Xu-Ying Pei, Lei Lei, Wenbo Chen, Yu-Tong Bao, Yi-Yang Ding, Zheng-Li Xu, Li-Juan Hu, Zhenfa Wan, Xue-Qiang Zhao, Zhi-Xiao Zhou, Xin Lin, Xiao-Jun Huang, Jia-Sheng Wang, Xiang-Yu Zhao

Signal Transduction and Targeted Therapy

DOI

2026

Inhibiting MDM2 enhances RIPK3-mediated necroptosis and synergizes with immune checkpoint blockade therapy

Ying-Xin Wu, Hanyang Yu, Zong-Xu Zhang, Weihang Xiong, Ze-Xian Zeng, Wei-Li Liu, Hailin Tu, Xin Lin

iScience

DOI

2026

CRISPRa screen unveils noncanonical NF-κB to boost the antitumor activity of TCR-based CAR-T cells

Hanyang Yu, Yingxin Wu, Yue Liu, Ruxue Wei, Zhixiao Zhou, Yu Li, Xin Lin, Jiasheng Wang

Cellular and Molecular Immunology

DOI

2025

An innovative ALA-CART platform exhibits high efficacy against cancers.

Jiasheng Wang, Xin Lin

Cancer Cell

DOI

2025

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells.

Chenliang Wang, S. Dai, Shanshan Zhang, Zheyu Zheng, Zhi-Xiao Zhou, Zhuojing Chen, Mingchao Wang, Yu-Mei Gao, Yan Xin, Weihang Xiong, Sihan Xiong, Xiao-Wen Wang, Aiping Wang, Xue-Qiang Zhao, Hang Li, Xin Lin

Immunity

DOI

2025

CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation

Qi Zhu, Jiajia Li, N. Liu, Lu Han, Zhi-Qiang Wu, Yao Wang, Xin Lin, Jian-Shu Wei, Wei-Dong Han

Cellular & Molecular Immunology

DOI

2025

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Xiaobing Wang, Yi Zhang, Huimin Wang, Xin Wu, Chao He, Suxian Lin, Kun Pang, Yang Li, Yue Chen, Xiao-Jing Tang, Xin Liu, Jia-Zheng Wang, Song-Ying Ye, Ran Yan, Tongxiang Guan, Bing Dai, Jing Lu, Hai-Yan He, Li Lin, Hong-Juan Lu, Ting Li, Ling Zhou, Lingying Ye, Juan Zhao, Yanfang Liu, N. Ta, Jun Wu, Wanshi Cai, Zhe Wan, Shasha Zhang, Ruya Sun, Xue-Qiang Zhao, Jia-Sheng Wang, Yong Lin, Bei-Fang Ning, Zhengqing Zhao, Xiao-Feng Tang, Juan Du, Zhiguo Mao, Yanran He, Hong-Li Zheng, Ling-Yun Sun, Xin Lin, Hu-Ji Xu

Nature Medicine

DOI

2025

Pro-tumor Macrophage Polarization Mediated by BMP2/4-ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment During Tumor Initiation.

Mingchao Wang, Zhihong Song, Hao Yuan, Chang Liu, Wei Wang, Naixue Yang, Keyong Sun, Shanshan Zhang, Xianhan Qin, Jing-Wei Li, Chen Tian, Run-Da Xu, Yixin Huang, Shicheng Hu, X. Nie, Zhixin Bie, Xinquan Liu, Yi Yao, Xin Lin, Chun-Hua Lin, Xun Lan

Cancer Research

DOI

2025

Converting TCR-based chimeric antigen receptor STAR into dual-specific targeting receptor for cancer immunotherapy.

Li Yu, Zhi-Xiao Zhou, Hanyang Yu, Yue Liu, Daosheng Huang, Jia-Sheng Wang, Xin Lin

Molecular Therapy

DOI

2025

CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death.

Zaopeng Yang, Shiqi Li, Renlin Lu, Zhanqi Wei, Xue-Qiang Zhao, Xin Lin

Journal of Immunology

DOI

2025

Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy

Hongjian Li, Yating Hu, Jing-Xuan Li, Jia He, Guo-Can Yu, Jia-Sheng Wang, Xin Lin

Signal Transduction and Targeted Therapy

DOI

2025

Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond

Li Yu, Yue Liu, Xin Lin

Cellular & Molecular Immunology

DOI

2025

Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors

Yuwei Tao, Tian Chen, Shaolong Qi, Ziqi Jia, Zheng Xu, Jingjing Meng, Guoyuan Xu, Haitian Hu, Xuxiang Wang, Tengjiang Zhang, Huiwen You, Xun Lan, Xin Lin, Guocan Yu, Haitao Zhou, Jiaqi Liu, Hanqiu Zheng

Nature Cancer

DOI

2024

T cell exhaustion in human cancers.

Kuan Kang, Xin Lin, Pan Chen, Huai Liu, Feng Liu, Wei Xiong, Gui-Yuan Li, Mei Yi, Xia-Yu Li, Hui Wang, Bo Xiang

Biochimica et biophysica acta. Reviews on cancer

DOI

2024

Regulatory mechanisms of PD-1/PD-L1 in cancers

Xin Lin, Kuan Kang, Pan Chen, Zhao-Yang Zeng, Gui-Yuan Li, Wei Xiong, Mei Yi, Bo Xiang

Molecular Cancer

DOI

2024

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens.

Daosheng Huang, Yi Li, Wei Rui, Keyong Sun, Zhi-Xiao Zhou, X. Lv, Li Yu, Junfan Chen, Jing Zhou, Vincent Liu, Jia-Sheng Wang, Xun Lan, Yang-Xin Fu, Xue-Qiang Zhao, Xin Lin

Cell Reports

DOI

2024

Identification of virus epitopes and reactive T-cell receptors from memory T cells without peptide synthesis

Lihui Wang, Run-Da Xu, Daosheng Huang, Pai Peng, Keyong Sun, Jie Hu, Bei-zhong Liu, L. Fang, Liwen Zhang, Xin Sun, Fei Gu, N. Tang, Ai-long Huang, Xin Lin, Xun Lan

Communications Biology

DOI

2024

LILRB4 Synthetic T-Cell Receptor and Antigen Receptor-T (STAR-T) for Refractory/Relapsed Acute Myeloid Leukemia: First-in-Human Phase I Clinical Trial

Xiang-Yu Zhao, Meng Lv, Yu Wang, Yi-Yang Ding, Zhi-Xiao Zhou, Jia-Sheng Wang, Hong-Li Zheng, Xue-Qiang Zhao, Xin Lin, Xiao-Jun Huang

Blood

DOI

2024

LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma

Lixin Gong, Hao Xuan Sun, Lanting Liu, Xiyue Sun, Teng Fang, Zhen Yu, Weiwei Sui, Jingyu Xu, Tingyu Wang, Fangshuo Feng, Lei Lei, Wei Rui, Yuxuan Liu, Xueqiang Zhao, Gang An, Xin Lin, Lugui Qiu, Mu Hao

Haematologica

DOI

2023

RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis

Jie Zhang, Hailin Tu, Zheyu Zheng, Xue-Qiang Zhao, Xin Lin

Oncogene

DOI

2023

Optimized collaboration of the first and third signals endows robust activity to T cells within the immunocompetent tumor microenvironment

Jian-Shu Wei, Xin Lin, W. Han

Cellular & Molecular Immunology

DOI

2023

IL-6 translation is a therapeutic target of human cytokine release syndrome

Yuzhuo Yang, Yajing Zhang, Xiaoyan Xing, Gang Xu, Xin Lin, Yao Wang, Meixia Chen, Chunmeng Wang, Bin Zhang, Weidong Han, Xiaoyu Hu

The Journal of Experimental Medicine

DOI

2023

Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis

Xia Xu, Hai‐Wen Lu, Jianxiong Li, Jielin Duan, Zhongwei Wang, Jia‐Wei Yang, Shuyi Gu, R.-G. Luo, Shuo Liang, Wei Tang, Fengying Zhang, Jingqing Hang, Juan Ge, Xin Lin, Jieming Qu, Xin‐Ming Jia, Jin‐Fu Xu

Chinese Medical Journal

DOI

2023

Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections

Xinxin Chi, Miaozhen Huang, Hailin Tu, Bin Zhang, Xin Lin, Huji Xu, Chen Dong, Xiaoyu Hu

Science China Life Sciences

DOI

2022

Efficacy of pp65‐specific TCR‐T cell therapy in treating cytomegalovirus infection after hematopoietic stem cell transplantation

Guang-Na Liu, Hua Chen, Xing-Yu Cao, Le-Mei Jia, Wei Rui, Hong-Li Zheng, Daosheng Huang, Fang Liu, Yue Liu, Xue-Qiang Zhao, P. Lu, Xin Lin

American journal of hematology/oncology

DOI

2022

A novel adoptive synthetic TCR and antigen receptor (STAR) T‐Cell therapy for B‐Cell acute lymphoblastic leukemia

Jiasheng Wang, Xian Zhang, Zhi-Xiao Zhou, Yue Liu, Li Yu, Le-Mei Jia, Junfang Yang, Jingjing Li, Hanyang Yu, Wenzhongyi Li, Guang-Na Liu, Wei Rui, Hong-Li Zheng, Xue-Qiang Zhao, Xin Lin, P. Lu

American journal of hematology/oncology

DOI

2022

CARD14 Missense Variant Underlying CARD14-Associated Papulosquamous Eruption with Beneficial Response to Secukinumab

Shangzhi Dai, Shanshan Zhang, Chenliang Wang, Xin Lin, Zhimiao Lin

JID Innovations

DOI

2022

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation

Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao, Xin Lin

Nature Communications

DOI

2022

Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

Dandan Yang, Gaofeng Pei, Shuangshuang Dong, Wenhao Zhang, Haiteng Deng, Xueqiang Zhao, Pilong Li, Xin Lin

Science China Life Sciences

DOI

2022

Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells

Liqing Cheng, Zhanqi Wei, Zaopeng Yang, Renlin Lu, Ming Yang, Muchun Yu, Naixue Yang, Shulin Li, Mingyi Gao, Xueqiang Zhao, Xin Lin

The Journal of Immunology

DOI

2022

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John M. Leong, Jan‐Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing‐Ren Zhang

The Journal of Experimental Medicine

DOI

2022

Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies

Hongjian Li, Kun Peng, Kai Yang, Wenbo Ma, Shaolong Qi, Xinyang Yu, Jia He, Xin Lin, Guocan Yu

Theranostics

DOI

2021

Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Guang-Na Liu, Wei Rui, Xue-Qiang Zhao, Xin Lin

Cellular & Molecular Immunology

DOI

2021

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner

Shanshan Zhang, Mingchao Wang, Chenliang Wang, Guifen Wang, Keyong Sun, Sihan Xiong, Liqing Cheng, Dandan Yang, Xin Lin, Xue-Qiang Zhao

Journal of Immunology

DOI

2021

Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death

Hailin Tu, Yong-Hong Tang, Jie Zhang, Liqing Cheng, Donghyun Joo, Xue-Qiang Zhao, Xin Lin

Journal of Immunology

DOI

2021

A Novel CMV-Specific TCR-T Cell Therapy Is Effective and Safe for Refractory CMV Infection after Allogeneic Hematopoietic Stem Cell Transplantation

Xing-Yu Cao, Guang-Na Liu, Jian-Ping Zhang, Yan-Li Zhao, Hua Chen, Hong-Li Zheng, Wei Rui, Le-Mei Jia, Xue-Qiang Zhao, Xin Lin, P. Lu

Blood

DOI

2021

HSPA13 facilitates NF-κB–mediated transcription and attenuates cell death responses in TNFα signaling

Chun Gao, Jianhua Deng, Hanchenxi Zhang, Xinran Li, Shuchen Gu, Mingjie Zheng, Mei Tang, Yezhang Zhu, Xin Lin, Jianping Jin, Long Zhang, Jun Huang, Jian Zou, Zongping Xia, Pinglong Xu, Li Shen, Bin Zhao, Xin‐Hua Feng

Science Advances

DOI

2021

Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment

Naixue Yang, Fansen Ji, Liqing Cheng, Jingzhe Lu, Xiaofeng Sun, Xin Lin, Xun Lan

npj Precision Oncology

DOI

2021

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

Yue Liu, Guangna Liu, Jiasheng Wang, Zheyu Zheng, Lemei Jia, Wei Rui, Daosheng Huang, Zhixiao Zhou, Liqun Zhou, Xin Wu, Song Lin, Xueqiang Zhao, Xin Lin

Science Translational Medicine

DOI

2020

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

Guang-Na Liu, Wei Rui, Hong-Li Zheng, Daosheng Huang, Fei Yu, Yue-Wei Zhang, Jia-Hong Dong, Xue-Qiang Zhao, Xin Lin

European Journal of Immunology

DOI

2020

A Feasibility and Safety Study of a Novel CD19-Directed Synthetic T-Cell Receptor and Antigen Receptor (STAR) T-Cell Therapy for Refractory and Relapsed (R/R) B Cell Acute Lymphoblastic Leukemia (B-ALL)

Xian Zhang, Jia-Sheng Wang, Yue Liu, Junfang Yang, Jingjing Li, Gailing Zhang, Yan-Ze Shi, Jiu-jiang He, Dan Song, Wen-Qian Li, S. Xia, Min Zhang, Zhi-Xiao Zhou, Le-Mei Jia, Hong-Li Zheng, Xin Lin, P. Lu

DOI

2019

Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

Liqing Cheng, N. Deng, Naixue Yang, Xue-Qiang Zhao, Xin Lin

Journal of Immunology

DOI

2019

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

Yong-Hong Tang, Hailin Tu, Jie Zhang, Xue-Qiang Zhao, Yi-Ni Wang, J. Qin, Xin Lin

Nature Communications

DOI

2019

CARMA3: Scaffold Protein Involved in NF-κB Signaling

Shi-Lei Zhang, Xin Lin

Frontiers in Immunology

DOI

2019

Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells

Dandan Yang, Xue-Qiang Zhao, Xin Lin

Cellular & Molecular Immunology

DOI

2019

Author response for "CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma"

Guang-Na Liu, Wei Rui, Hong-Li Zheng, Daosheng Huang, Fei Yu, Yue-Wei Zhang, Jia-Hong Dong, Xue-Qiang Zhao, Xin Lin

DOI

2019

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

Li-Chuan Chan, Chia‐Wei Li, Weiya Xia, Jung-Mao Hsu, Heng‐Huan Lee, Jong‐Ho Cha, Hung-Ling Wang, Wenhao Yang, Er-Yen Yen, Wei‐Chao Chang, Zhengyu Zha, Seung‐Oe Lim, Yun‐Ju Lai, Chunxiao Liu, Jielin Liu, Qiongzhu Dong, Yi Yang, Linlin Sun, Yongkun Wei, Lei Nie, Jennifer L. Hsu, Hui Li, Qing‐Hai Ye, Manal M. Hassan, Hesham M. Amin, Ahmed Omar Kaseb, Xin Lin, Shao‐Chun Wang, Mien‐Chie Hung

Journal of Clinical Investigation

DOI

2018

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Ting-Ting Wang, C. Fan, Anran Yao, Xing-Wei Xu, Guo-Xing Zheng, Y. You, Chang-Ying Jiang, Xue-Qiang Zhao, Ya-Yi Hou, M. Hung, Xin Lin

Immunity

DOI

2018

Gain‐of‐Function Mutation of Card14 Leads to Spontaneous Psoriasis‐like Skin Inflammation through Enhanced Keratinocyte Response to IL‐17A

Mingchao Wang, Shanshan Zhang, Guo-Xing Zheng, Junjiu Huang, Song-Yang Zhou, Xue-Qiang Zhao, Xin Lin

Immunity

DOI

2018

CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses

Xia Xu, Jin-Fu Xu, Guo-Xing Zheng, Hai-Wen Lu, Jie-Lin Duan, Wei Rui, Jian-Hong Guan, Liqing Cheng, Dan-Dan Yang, Mingchao Wang, Quanzhen Lv, Jianxiong Li, Xue-Qiang Zhao, Chun-Xia Chen, P. Shi, Xin-Ming Jia, Xin Lin

Nature Immunology

DOI

2018

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis

Yong-Hong Tang, Donghyun Joo, Guang-Na Liu, Hailin Tu, Jeffrey You, Jian-Ping Jin, Xue-Qiang Zhao, M. Hung, Xin Lin

Journal of Biological Chemistry

DOI

2018

RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death

Yong-Hong Tang, Hailin Tu, Guang-Na Liu, Guo-Xing Zheng, Mingchao Wang, Lin Li, Xue-Qiang Zhao, Xin Lin

Journal of Immunology

DOI

2018

Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution

Dingka Song, Junchen Meng, Jie Cheng, Zheng Fan, Pengyu Chen, Hefei Ruan, Zhongyuan Tu, Ning Kang, Nan Li, Ying Xin Xu, Xiaobo Wang, Fei Shu, Libing Mu, Tengfei Li, Wenran Ren, Xin Lin, Jun Zhu, Xiaohong Fang, Matthias Amrein, Weihui Wu, Li‐Tang Yan, Junhong Lü, Tie Xia, Yan Shi

Nature Microbiology

DOI

2018

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Guoxing Zheng, Changying Jiang, Yulin Li, Dandan Yang, Youcai Ma, Bing Zhang, Xuan Li, Pei Zhang, Xiaoyu Hu, Xueqiang Zhao, Jie Du, Xin Lin

Protein & Cell

DOI

2017

Targeting the Paracaspase MALT1: A Potential Therapy to Overcome Ibrutinib Resistance in Relapsed/Refractory Mantle Cell Lymphoma Patients

Chang-Ying Jiang, Shengjian Huang, Yang Liu, Carrie J. Li, Hui Guo, Jeff F. Wang, E. Lopez, Hui Zhang, E. Lorence, Maria Merolle, S. Balaji, Makhdum Ahmed, K. Nomie, Xin Lin, Liang Zhang, Michael L. Wang

DOI

2017

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

Shi-Lei Zhang, D. Pan, Xin-Ming Jia, Xin Lin, Xue-Qiang Zhao

Protein & Cell

DOI

2017

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity

Shasha Chen, Chenxu Cai, Zehua Li, Guangao Liu, Yuande Wang, Marzenna Blonska, Dan Li, Juan Du, Xin Lin, Meixiang Yang, Zhongjun Dong

The Journal of Experimental Medicine

DOI

2016

CARMA3 is a host factor regulating the balance of inflammatory and antiviral responses against viral infection

Chang-Ying Jiang, Zhi-Cheng Zhou, Y. Quan, Shi-Lei Zhang, Ting-Ting Wang, Xue-Qiang Zhao, C. Morrison, M. Heise, Wenqian He, Matthew S. Miller, Xin Lin

Cell Reports

DOI

2016

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31

Donghyun Joo, Yong-Hong Tang, M. Blonska, Jian-Ping Jin, Xue-Qiang Zhao, Xin Lin

Molecular and Cellular Biology

DOI

2015

The CBM Complex Underwrites NF-κB Activation to Promote HER2-Associated Tumor Malignancy

D. Pan, Yifan Zhu, Zhi-Cheng Zhou, Ting-Ting Wang, H. You, Chang-Ying Jiang, Xin Lin

Molecular Cancer Research

DOI

2015

MALT1 is required for EGFR induced NF-κB activation and contributes to EGFR-driven lung cancer progression

D. Pan, Chang-Ying Jiang, Zhong-Liang Ma, M. Blonska, M. You, Xin Lin

Oncogene

DOI

2014

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation*

Xue-Qiang Zhao, Le-Le Zhu, Q. Chang, Chang-Ying Jiang, Y. You, Tian-Ming Luo, Xin-Ming Jia, Xin Lin

Journal of Biological Chemistry

DOI

2014

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

Xin-Ming Jia, B. Tang, Le-Le Zhu, Yan-hui Liu, Xue-Qiang Zhao, Sara Gorjestani, Yen-Michael S. Hsu, Long Yang, Jian-Hong Guan, Guo-Tong Xu, Xin Lin

Journal of Experimental Medicine

DOI

2013

Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.

Changju Qu, Yadong Liu, K. Kunkalla, Rajesh R. Singh, M. Blonska, Xin Lin, N. Agarwal, F. Vega

Blood

DOI

2013

C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.

Le-Le Zhu, Xue-Qiang Zhao, Chang-Ying Jiang, Y. You, Xiao-ping Chen, Yuan-Ying Jiang, Xin-Ming Jia, Xin Lin

Immunity

DOI

2013

Abstract 4114: Trimeric G protein-CARMA1 axis links smoothened to NF-κB activation in diffuse large B-cell lymphoma.

Changju Qu, Yadong Liu, K. Kunkalla, Rajesh R. Singh, M. Blonska, N. Agarwal, Xin Lin, F. Vega

DOI

2013

Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

M. Blonska, Donghyun Joo, R. Nurieva, Xue-Qiang Zhao, P. Chiao, Shao-Cong Sun, C. Dong, Xin Lin

Science Signaling

DOI

2012

JunB and GATA 3 Transcription Factors Cytokine Expression through Regulating CARMA 1 Controls Th 2 Cell-Specific

Zweidler-McKay, Qing-Yu Zhao, Xin Lin, M. Blonska, Donghyun Joo

2012

CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors

M. Blonska, Donghyun Joo, P. Zweidler-McKay, Qing-Yu Zhao, Xin Lin

Journal of Immunology

DOI

2012

Regulation of NF-κB by the CARD proteins

Chang-Ying Jiang, Xin Lin

Immunological Reviews

DOI

2011

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

M. Blonska, Xin Lin

Cell Research

DOI

2011

CARMA3 is crucial for EGFR-induced activation of NF-κB and tumor progression

T. Jiang, B. Grabiner, Yifan Zhu, Chang-Ying Jiang, Hongxiu Li, Y. You, Jingyu Lang, M. Hung, Xin Lin

Cancer Research

DOI

2010

CARD9 Mediates Dectin-2-induced IκBα Kinase Ubiquitination Leading to Activation of NF-κB in Response to Stimulation by the Hyphal Form of Candida albicans*

Liang-Kuan Bi, Sara Gojestani, Weihui Wu, Yen-Michael S. Hsu, Jiayuan Zhu, K. Ariizumi, Xin Lin

Journal of Biological Chemistry

DOI

2010

The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation

R. Nurieva, Shu-Ling Zheng, W. Jin, Yeonseok Chung, Yong-Liang Zhang, G. Martinez, J. Reynolds, Sung-Ling Wang, Xin Lin, Shao-Cong Sun, G. Lozano, C. Dong

Immunity

DOI

2009

CARMA1-mediated NF-κB and JNK activation in lymphocytes

M. Blonska, Xin Lin

Immunological Reviews

DOI

2009

CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex

Weihui Wu, Yen-Michael S. Hsu, Liang-Kuan Bi, Song-Yang Zhou, Xin Lin

Nature Immunology

DOI

2007

The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens

Yen-Michael S. Hsu, Yong-Liang Zhang, Y. You, Donghai Wang, Hongxiu Li, Omar Duramad, Xiao-Feng F. Qin, C. Dong, Xin Lin

Nature Immunology

DOI

2007

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation

B. Grabiner, M. Blonska, Pei-Chun Lin, Y. You, Donghai Wang, Ji-Yuan Sun, B. Darnay, C. Dong, Xin Lin

DOI

2007

The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway.

M. Blonska, B. Pappu, R. Matsumoto, Hongxiu Li, B. Su, De-Min Wang, Xin Lin

Immunity

DOI

2007

Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated NF-κB Activation

H. Zeng, Lie Di, Guoping Fu, Yu-Hong Chen, Xiang Gao, Lang-Lai Xu, Xin Lin, R. Wen

Molecular and Cellular Biology

DOI

2007

Caveolin-1 Triggers T-cell Activation via CD26 in Association with CARMA1*

K. Ohnuma, M. Uchiyama, T. Yamochi, K. Nishibashi, O. Hosono, Nozomu Takahashi, Shinichiro Kina, Hirotoshi Tanaka, Xin Lin, N. Dang, C. Morimoto

Journal of Biological Chemistry

DOI

2007

Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors

Donghai Wang, Y. You, Pei-Chun Lin, L. Xue, S. Morris, H. Zeng, R. Wen, Xin Lin

Proceedings of the National Academy of Sciences of the United States of America

DOI

2007

CARMA1 Coiled-coil Domain Is Involved in the Oligomerization and Subcellular Localization of CARMA1 and Is Required for T Cell Receptor-induced NF-κB Activation*

M. Tanner, W. Hanel, S. Gaffen, Xin Lin

Journal of Biological Chemistry

DOI

2007

Erratum: Bcl10 plays a critical role in NF-κB activation induced by G protein-coupled receptors (Proceedings of the National Academy of Sciences of the United States of America (January 2, 2007) 1, 104, (145-150) DOI: 10.1073/pnas.0601894104)

Donghai Wang, Y. You, Pei-Chun Lin, L. Xue, S. Morris, H. Zeng, R. Wen, Xin Lin

DOI

2006

Potential role of CARMA1 in CD40‐induced splenic B cell proliferation and marginal zone B cell maturation

Bhanu P. Pappu, Xin Lin

European Journal of Immunology

DOI

2005

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation.

R. Matsumoto, Donghai Wang, M. Blonska, Hongxiu Li, Masayuki Kobayashi, B. Pappu, Yu-Hong Chen, De-Min Wang, Xin Lin

Immunity

DOI

2004

Crucial Role for Nuclear Factor of Activated T Cells in T Cell Receptor-mediated Regulation of Human Interleukin-17*

Xikui Liu, Xin Lin, S. Gaffen

Journal of Biological Chemistry

DOI

2004

The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling.

Xin Lin, De-Min Wang

Seminars in Immunology

DOI

2004

CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1

Donghai Wang, R. Matsumoto, Y. You, Tuanjie Che, Xue-Yan Lin, S. Gaffen, Xin Lin

Molecular and Cellular Biology

DOI

2004

MALT1/Paracaspase Is a Signaling Component Downstream of CARMA1 and Mediates T Cell Receptor-induced NF-κB Activation*

Tuanjie Che, Y. You, Donghai Wang, M. Tanner, V. Dixit, Xin Lin

Journal of Biological Chemistry

DOI

2002

A requirement for CARMA1 in TCR-induced NF-κB activation

Donghai Wang, Y. You, Sara M. Case, L. McAllister-Lucas, Lin Wang, P. Distefano, G. Núñez, J. Bertin, Xin Lin

Nature Immunology

DOI

2000

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

Xin Lin, A. O’Mahony, Y. Mu, R. Geleziunas, W. Greene

Molecular and Cellular Biology

DOI

1999

The Proto-Oncogene Cot Kinase Participates in CD3/CD28 Induction of NF-κB Acting through the NF-κB-Inducing Kinase and IκB Kinases

Xin Lin, E. Cunningham, Y. Mu, R. Geleziunas, W. Greene

DOI

精选作品

期刊论文

The cGAS-STING pathway in cancer: friend or foe

Abstract 4006: Iterative engineering of GPC-3 targeted synthetic TCR and antigen receptor (STAR) cells in advanced solid tumors

Dual epitope anti-LILRB4 synthetic T-cell receptor and antigen receptor (STAR)-T-cell therapy for relapsed/refractory acute myeloid leukemia

Inhibiting MDM2 enhances RIPK3-mediated necroptosis and synergizes with immune checkpoint blockade therapy

CRISPRa screen unveils noncanonical NF-κB to boost the antitumor activity of TCR-based CAR-T cells

An innovative ALA-CART platform exhibits high efficacy against cancers.

Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells.

CD2 augmentation enhances CAR-T-cell efficacy via immunological synapse remodeling and T-cell exhaustion mitigation

Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Pro-tumor Macrophage Polarization Mediated by BMP2/4-ACVR1 Signaling Orchestrates an Immunosuppressive Microenvironment During Tumor Initiation.

Converting TCR-based chimeric antigen receptor STAR into dual-specific targeting receptor for cancer immunotherapy.

CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death.

Intranasal prime-boost RNA vaccination elicits potent T cell response for lung cancer therapy

Transitioning from native to synthetic receptors: broadening T-cell engineering and beyond

Targeting both death and paracaspase domains of MALT1 with antisense oligonucleotides overcomes resistance to immune-checkpoint inhibitors

T cell exhaustion in human cancers.

Regulatory mechanisms of PD-1/PD-L1 in cancers

TCR-mimicking STAR conveys superior sensitivity over CAR in targeting tumors with low-density neoantigens.

Identification of virus epitopes and reactive T-cell receptors from memory T cells without peptide synthesis

LILRB4 Synthetic T-Cell Receptor and Antigen Receptor-T (STAR-T) for Refractory/Relapsed Acute Myeloid Leukemia: First-in-Human Phase I Clinical Trial

LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma

RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis

Optimized collaboration of the first and third signals endows robust activity to T cells within the immunocompetent tumor microenvironment

IL-6 translation is a therapeutic target of human cytokine release syndrome

Heterozygous CARD9 mutation favors the development of allergic bronchopulmonary aspergillosis

Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections

Efficacy of pp65‐specific TCR‐T cell therapy in treating cytomegalovirus infection after hematopoietic stem cell transplantation

A novel adoptive synthetic TCR and antigen receptor (STAR) T‐Cell therapy for B‐Cell acute lymphoblastic leukemia

CARD14 Missense Variant Underlying CARD14-Associated Papulosquamous Eruption with Beneficial Response to Secukinumab

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation

Bcl10 phosphorylation-dependent droplet-like condensation positively regulates DNA virus-induced innate immune signaling

Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies

Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment

Intrinsic Abnormalities of Keratinocytes Initiate Skin Inflammation through the IL-23/T17 Axis in a MALT1-Dependent Manner

Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death

A Novel CMV-Specific TCR-T Cell Therapy Is Effective and Safe for Refractory CMV Infection after Allogeneic Hematopoietic Stem Cell Transplantation

HSPA13 facilitates NF-κB–mediated transcription and attenuates cell death responses in TNFα signaling

Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment

Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors

CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma

A Feasibility and Safety Study of a Novel CD19-Directed Synthetic T-Cell Receptor and Antigen Receptor (STAR) T-Cell Therapy for Refractory and Relapsed (R/R) B Cell Acute Lymphoblastic Leukemia (B-ALL)

Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

CARMA3: Scaffold Protein Involved in NF-κB Signaling

Bcl10 is required for the development and suppressive function of Foxp3+ regulatory T cells

Author response for "CXCR2‐modified CAR‐T cells have enhanced trafficking ability that improves treatment of hepatocellular carcinoma"

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells

Gain‐of‐Function Mutation of Card14 Leads to Spontaneous Psoriasis‐like Skin Inflammation through Enhanced Keratinocyte Response to IL‐17A

CARD9S12N facilitates the production of IL-5 by alveolar macrophages for the induction of type 2 immune responses

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFα-induced apoptosis

RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death

Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution

TMEM43-S358L mutation enhances NF-κB-TGFβ signal cascade in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Targeting the Paracaspase MALT1: A Potential Therapy to Overcome Ibrutinib Resistance in Relapsed/Refractory Mantle Cell Lymphoma Patients

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity

CARMA3 is a host factor regulating the balance of inflammatory and antiviral responses against viral infection

Regulation of Linear Ubiquitin Chain Assembly Complex by Caspase-Mediated Cleavage of RNF31

The CBM Complex Underwrites NF-κB Activation to Promote HER2-Associated Tumor Malignancy

MALT1 is required for EGFR induced NF-κB activation and contributes to EGFR-driven lung cancer progression

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation*

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity

Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma.

C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.

Abstract 4114: Trimeric G protein-CARMA1 axis links smoothened to NF-κB activation in diffuse large B-cell lymphoma.

Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

JunB and GATA 3 Transcription Factors Cytokine Expression through Regulating CARMA 1 Controls Th 2 Cell-Specific

CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors

Regulation of NF-κB by the CARD proteins

NF-κB signaling pathways regulated by CARMA family of scaffold proteins

CARMA3 is crucial for EGFR-induced activation of NF-κB and tumor progression

CARD9 Mediates Dectin-2-induced IκBα Kinase Ubiquitination Leading to Activation of NF-κB in Response to Stimulation by the Hyphal Form of Candida albicans*

The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation

CARMA1-mediated NF-κB and JNK activation in lymphocytes

CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex