俞春东｜厦门大学｜学者主页

2026

Integrated Network Pharmacology, Transcriptomics, and Experimental Validation Identify PI3K-AKT and STAT3 as Key Pathways for Pien Tze Huang Against Liver and Colorectal Cancers

Yilin Hong, Wei Xi, Xinyuan Liu, Hanshi Guo, J ZHANG, Jingna Yuan, Siyu Chen, Shicong Wang, Guoxiang Chi, Chundong Yu

Current Pharmaceutical Design

2026

Yindan-Pinggan Capsules Alleviate Steatotic Liver Disease Through Modulating Multiple Signaling Pathways in Mice

Chundong Yu, Bei Li, Junjie Zhang, Hanshi Guo, Guifang Lin, Jianyuan Xie, Chen Zhao, Lijuan Cai, Qihong Deng, Shuhui Cai, Xinyuan Liu, Wei Xi, Pingli Mo, Fei Hong, Shicong Wang, Chundong Yu

Current Pharmaceutical Design

DOI

2026

Yindan Pinggan Capsule Suppresses Hepatocellular Carcinoma Proliferation via TGR5-mediated Dual Inhibition of YAP and Hedgehog Pathways

Yilin Hong, Wei Xi, Hanshi Guo, Jiadi Liang, Fudong Zhang, Junjie Zhang, Yong Zhang, Chundong Yu

Current Pharmaceutical Design

DOI

2026

Histone Demethylase JMJD2D Suppresses Influenza A Virus Infection by Promoting RIG-I Expression

Xiaochun Xia, Jiadi Liang, Hanshi Guo, Fudong Zhang, J ZHANG, Chundong Yu, Pingli Mo, Yilin Hong

Biomolecules

DOI

2026

The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets

Yilin Hong, Hanshi Guo, Qi Chen, Chundong Yu

Molecular Biomedicine

DOI

2026

Histone demethylase JMJD2D promotes macrophage IL-12b expression and contributes to host defense against Listeria monocytogenes infection

Yilin Hong, Hanshi Guo, Bei Li, Jing Jin, Yang Zhao, Junjie Zhang, Jingna Yuan, Xiaochun Xia, Chundong Yu

Frontiers in Cellular and Infection Microbiology

DOI

2026

Histone demethylase JMJD1A protects mice from enteric bacterial infection by upregulating CCL8 expression to recruit macrophages and CD4+ T cells

Guifang Lin, Lichun Yang, Shuyan Jiang, Yong Zhang, Ping Luo, Weihua Li, Jianming Xu, Gongpeng Xiong, Chundong Yu, Wenbo Chen

PLoS Pathogens

DOI

2025

ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion

Chuanzhong Huang, Ling Wang, Changhua Zhuo, Wenxin Chen, Hongmei Fan, Yilin Hong, Yu Zhang, Dongmei Zhou, Wansong Lin, Lingyu Zhang, Jingjing Zhao, Shuping Chen, Chundong Yu, Yunbin Ye

Proceedings of the National Academy of Sciences

DOI

2024

Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP‐9

Zhang-Wei Tong, Yong Zhang, Peng Guo, Wei Wang, Qiang Chen, Jing Jin, Shi-xiao Liu, Chundong Yu, Ping-Li Mo, Lei Zhang, Jun Huang

Journal of Cellular and Molecular Medicine

DOI

2024

Targeting Nuclear Receptor Coactivator SRC‐1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD‐L1

Yilin Hong, Qiang Chen, Zinan Wang, Yong Zhang, Bei Li, Hanshi Guo, Chuanzhong Huang, Xu Kong, Pingli Mo, Nengming Xiao, Jianming Xu, Yunbin Ye, Chundong Yu

Advanced Science

DOI

2024

The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis

Qiang Chen, Peng Guo, Yilin Hong, Pingli Mo, Chundong Yu

Cell & Bioscience

DOI

2024

Abstract 1688: Nuclear receptor coactivator SRC-1 promotes colorectal cancer immune escape by enhancing PD-L1 transcription and protein stability

Yilin Hong, Qiang Chen, Zinan Wang, Yong Zhang, Bei Li, Xu Kong, Pingli Mo, Nengming Xiao, Jianming Xu, Yunbin Ye, Chundong Yu

Cancer Research

DOI

2024

Downregulation of Brf1 Induces Liver Failure and Inhibits Hepatocellular Carcinoma Progression by Promoting Apoptosis

Yaping Xu, Chundong Yu, Hongbin Zhang, Tao Wang, Yujian Liu, Lupeng Wu, Shuping Zhong, Zaifa Hong

Journal of Cancer

DOI

2024

Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression

Yong Zhang, Bei Li, Yilin Hong, Ping Luo, Zaifa Hong, Xiaochun Xia, Pingli Mo, Chundong Yu, Wenbo Chen

PLoS Pathogens

DOI

2023

Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

Bei Li, Yong Zhang, Xin-Yuan Liu, Ziyang Zhang, Shu-Qing Zhuang, Xiaoli Zhong, Wenbo Chen, Yi-Lin Hong, Ping-Li Mo, Shuh-ren Lin, Shi-Cong Wang, Chundong Yu

Journal of Pharmaceutical Analysis

DOI

2023

JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication

Xu Kong, Zuo-Feng Liu, Ru-Yi Zhang, Fu'an Xie, Ru-Bing Liang, Yong Zhang, Lingling Yu, Wensheng Yang, Xi Li, Qiang Chen, Bei Li, Yi-Lin Hong, Ming Li, Xiaogang Xia, Lingwei Gu, L. Fu, Xiao-Hua Li, Ye Shen, Ting Wu, Chundong Yu, Wen-Gang Li

JHEP Reports

DOI

2022

Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

Pathirennehelage Chandrasekera, Mark Perfetto, Congyu Lu, Minghui Zhuo, H. Bahudhanapati, Jiejing Li, Wei-Chi Chen, P. Kulkarni, L. Christian, Jun Liu, Yvette Y. Yien, Chundong Yu, Shuo Wei

Journal of Biological Chemistry

DOI

2022

Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling

Qiang Chen, Shu-Juan Zhuang, Yi-Lin Hong, Lingtao Yang, P. Guo, Ping-Li Mo, Kesong Peng, Wen-Gang Li, Neng-Ming Xiao, Chundong Yu

Oncogene

DOI

2022

Traditional Chinese Medicine Pien-Tze-Huang Inhibits Colorectal Cancer Growth and Immune Evasion by Reducing β-catenin Transcriptional Activity and PD-L1 Expression

Qiang Chen, Yi-Lin Hong, Shih-Hua Weng, Peng Guo, Bei Li, Yong Zhang, Chundong Yu, Shi-Cong Wang, Ping-Li Mo

Frontiers in Pharmacology

DOI

2022

Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling

P. Guo, Qiang Chen, Kesong Peng, Jian-Yuan Xie, Junjia Liu, Wenjing Ren, Zhang-Wei Tong, Ming Li, Jian-Ming Xu, Yongyou Zhang, Chundong Yu, Ping-Li Mo

Oncogene

DOI

2022

Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers

Qiang Chen, Kesong Peng, Ping-Li Mo, Chundong Yu

Cancers

DOI

2021

SRC-3 deficiency protects host from Listeria monocytogenes infection through increasing ROS production and decreasing lymphocyte apoptosis.

Xiaochun Xia, Yuan Chen, Jian-Ming Xu, Chundong Yu, Wenbo Chen

International Immunopharmacology

DOI

2021

Steroid Receptor Coactivator-3 Is Required for Inhibition of the Intestinal Muscularis Inflammatory Response of Postoperative Ileus in Mice

K. Zou, Wenbo Chen, J. Dai, Ping-Li Mo, Chundong Yu, Jianming Xu, San-Gang Wu, Rengong Zhuo, Guoqiang Su

Inflammation

DOI

2021

Correction to: Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Kesong Peng, Minghui Zhuo, Ming Li, Qiang Chen, Ping-Li Mo, Chundong Yu

Oncogene

DOI

2020

肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生

周大旺，姬素渊，刘清许，张世浩，陈青花，王聪，Weiji Zhang，Chen Xiao，Yuxi Li，Cheng Nian，Jiaxin Li，Junhong Li，Jing Geng，Lixin Hong，Changchuan Xie，Ying He，Xing Chen，Xun Li，Zhen-Yu Yin，Han You，Kwang-Huei Lin，Qiao Wu，Chundong Yu，Randy L.Johnson，Li Wang，Lanfen Chen，Fen Wang

《科学新闻》

2020

Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression

Yuan Deng, Ming Li, Minghui Zhuo, P. Guo, Qiang Chen, Ping-Li Mo, Wen-Gang Li, Chundong Yu

Journal of Biological Chemistry

DOI

2020

Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Minghui Zhuo, Wenbo Chen, Shaohui Shang, P. Guo, Kesong Peng, Ming Li, Ping-Li Mo, Yongyou Zhang, Xing-Feng Qiu, Wen-Gang Li, Chundong Yu

Oncogene

DOI

2020

Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression

Ming Li, Yuan Deng, Minghui Zhuo, Hui Zhou, Xu Kong, Xiaogang Xia, Zhao-Jie Su, Qiang Chen, P. Guo, Ping-Li Mo, Chundong Yu, Wen-Gang Li

Theranostics

DOI

2020

Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Kesong Peng, Minghui Zhuo, Ming Li, Qiang Chen, Ping-Li Mo, Chundong Yu

Oncogene

DOI

2019

Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.

Kesong Peng, Le-Le Kou, Li Yu, Chaonan Bai, Ming Li, Ping-Li Mo, Wen-Gang Li, Chundong Yu

Gastroenterology

DOI

2019

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.

Suyuan Ji, Qingxu Liu, Shihao Zhang, Qing-Hua Chen, Cong Wang, Weiji Zhang, Chen Xiao, Yuxi Li, Nian Cheng, Jiaxin Li, Jun-Hong Li, Jing Geng, Li-Xin Hong, Chang-Chuan Xie, Ying He, Xing Chen, Xun Li, Zhen-Yu Yin, H. You, K. Lin, Qiao Wu, Chundong Yu, Randy L. Johnson, Li Wang, Lanfen Chen, Fen Wang, Da-Wang Zhou

Developmental Cell

DOI

2019

Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation

Ming Li, Yi Wang, Xiaochun Xia, Ping-Li Mo, Jian-Ming Xu, Chundong Yu, Wen-Gang Li

Cell & Bioscience

DOI

2018

Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling

Kesong Peng, Guoqiang Su, J. Ji, Xiaojiao Yang, Mengmeng Miao, Ping-Li Mo, Ming Li, Jian-Ming Xu, Wen-Gang Li, Chundong Yu

Journal of Biological Chemistry

DOI

2018

SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression

Wenbo Chen, Minghui Zhuo, Xu-Qiang Lu, Xiaochun Xia, Yang Zhao, Zheng-Rong Huang, Jian-Ming Xu, Wei-Hua Li, Chundong Yu

International Journal on Biological Sciences

DOI

2018

731 - Histone Demethylase JMJD2D Promotes Colorectal Cancer Progression through Enhancement of WNT/B-Catenin Pathway

Kesong Peng, Chundong Yu

DOI

2018

Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens.

Wenbo Chen, Ping-Li Mo, Chundong Yu

Critical Reviews in Immunology

DOI

2017

Steroid receptor coactivator 3 contributes to host defense against enteric bacteria by recruiting neutrophils via upregulation of CXCL2 expression

Wenbo Chen, Xu-Qiang Lu, Yuan Chen, Ming Li, Ping-Li Mo, Zhang-Wei Tong, Wei Wang, W. Wan, Guoqiang Su, Jian-Ming Xu, Chundong Yu

Journal of Immunology

DOI

2017

E3 ubiquitin ligase FBW7α inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E.

Ming Li, Ling Ouyang, Zhi-Gang Zheng, D. Xiang, Ai-Jun Ti, Leilei Li, Yu-Zhen Dan, Chundong Yu, Wen-Gang Li

Oncology Report

DOI

2016

Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

Sidra Majaz, Zhang-Wei Tong, Kesong Peng, Wei Wang, Wenjing Ren, Ming Li, Kun Liu, Ping-Li Mo, Wen-Gang Li, Chundong Yu

Cell & Bioscience

DOI

2016

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria

Chong Teik Tan, Qi-Ling Zhou, Yu‐Chin Su, Nai Yang Fu, Hao‐Chun Chang, Ran N. Tao, Sunil Kumar Sukumaran, Shairaz Baksh, Yee‐Joo Tan, Kanaga Sabapathy, Chundong Yu, Victor Chun Kong Yu

Cell Reports

DOI

2016

Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma

Ming Li, Wei Wang, Yuzhen Dan, Zhangwei Tong, Wenbo Chen, Liping Qin, Kun Liu, Wengang Li, Pingli Mo, Chundong Yu

Oncotarget

DOI

2015

Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/β-Catenin Signaling*

Zhang-Wei Tong, Ming Li, Wei Wang, Ping-Li Mo, Li Yu, Kun Liu, Wenjing Ren, Wen-Gang Li, Hao Zhang, Jian-Ming Xu, Chundong Yu

Journal of Biological Chemistry

DOI

2015

Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator not only for steroid receptors, such as androgen receptor and estrogen receptor, but also for other transcription factors. SRC-1 has been shown to play an important role in the p

Li Yu, Hao Zhang, Wen-Gang Li, Ming Li, Jian-Ming Xu, Chundong Yu, Wei Wang, Zhang-Wei Tong, Wenjing Ren, Ping-Li Mo, Kun Liu

2014

Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing Notch signaling

Ping-Li Mo, Qi-Ling Zhou, Lei Guan, Yi Wang, Wei Wang, Mengmeng Miao, Zhang-Wei Tong, Ming Li, Sidra Majaz, Yong-Hong Liu, Guoqiang Su, Jian-Ming Xu, Chundong Yu

Oncogene

DOI

2014

Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway.

Wenjiao Li, Ming Li, Xinhui Su, L. Qin, Mengmeng Miao, Chundong Yu, Yue-Mao Shen, Q. Luo, Qiang Chen

Biochimie

DOI

2014

[Down-regulation of TSPO expression doesn't affect the productions of TNF-α, IL-1β and IL-6 in LPS-stimulated BV-2 microglia].

Xiaofeng Dou, Yafei Zhang, Qiang Chen, Wenjiao Li, Yang Li, Chundong Yu, Xinhui Su

PubMed

2013

Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice

Xiaochun Xia, Qiang Chen, Kun Liu, Pingli Mo, Jingwei Zhu, Ming-qiang Zhuang, Yuemao Shen, Chundong Yu

International Immunopharmacology

DOI

2012

Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasiveness

Yong-Hong Liu, Zhang-Wei Tong, Ting Li, Qiang Chen, L. Zhuo, Wen-Gang Li, R. Wu, Chundong Yu

Hepatology

DOI

2012

Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways

Qiang Chen, Wenjiao Li, Yunyan Wan, Xiaochun Xia, Qiao Wu, Yan-Ling Chen, Zhi-Shuang Lai, Chundong Yu, Wen-Gang Li

Hepatology

DOI

2012

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

Lei Zhang, Yang Mei, Nai Yang Fu, Li Guan, Wei Dong Xie, Huihui Liu, Chundong Yu, Zhenyu Yin, Victor Chun Kong Yu, Han You

Proceedings of the National Academy of Sciences

DOI

2012

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

Yan-yan Zhan, Yan Chen, Qian Zhang, Jia-Jia Zhuang, Min Tian, Hang‐zi Chen, Lianru Zhang, Hongkui Zhang, Jianping He, Weijia Wang, Rong Wu, Yuan Wang, Chunfang Shi, Kai S. Yang, Anzhong Li, Yong-zhen Xin, Terytty Yang Li, James Y. Yang, Zhonghui Zheng, Chundong Yu, Sheng‐Cai Lin, Chawnshang Chang, Pei‐Qiang Huang, Tianwei Lin, Qiao Wu

Nature Chemical Biology

DOI

2011

SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

Teng-Hui Chen, Qiang Chen, Yixiang Xu, Qi-Ling Zhou, Jingwei Zhu, H. Zhang, Qiao Wu, Jian-Ming Xu, Chundong Yu

Journal of Hepatology

DOI

2011

Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease.

Qiang Chen, Yuan Jiang, Yuan An, Na Zhao, Yang Zhao, Chundong Yu

Biochemical and Biophysical Research Communications - BBRC

DOI

2011

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

Lu-ming Yao, Jianping He, Hang‐zi Chen, Yuan Wang, Weijia Wang, Rong Wu, Chundong Yu, Qiao Wu

Carcinogenesis

DOI

2010

SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis

Qiang Chen, Teng-Hui Chen, Yixiang Xu, Jingwei Zhu, Yuan Jiang, Yang Zhao, Jian-Ming Xu, Chundong Yu

Journal of Immunology

DOI

2010

Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology

B. York, Chundong Yu, J. Sagen, Zhaoliang Liu, B. Nikolai, R. Wu, M. Finegold, Jian-Ming Xu, B. O'Malley

Proceedings of the National Academy of Sciences of the United States of America

DOI

2010

Abstract 3093: Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness

Yixiang Xu, Qiang Chen, Wen-Gang Li, Xinhui Su, Teng-Hui Chen, Yong-Hong Liu, Yang Zhao, B. O'Malley, Chundong Yu

DOI

2010

Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness

Youzhi Xu, Qiang Chen, W Li, Xinhui Su, Tingting Chen, Y Liu, Yujie Zhao, Chundong Yu

Oncogene

DOI

2009

FGFR4对胆汁酸代谢的调控作用

姜远，俞春东

《生命的化学》

2007

An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

Chundong Yu, B. York, Shu Wang, Qin Feng, Jian-Ming Xu, B. O'Malley

Molecules and Cells

DOI

2006

Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis.

Xinqiang Huang, Chundong Yu, C. Jin, Masashi Kobayashi, Courtney A. Bowles, Fen Wang, W. Mckeehan

Cancer Research

DOI

2006

Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3.

Paola Mussi, Chundong Yu, B. O'Malley, Jian-Ming Xu

Molecular Endocrinology

DOI

2006

Forced expression of hepatocyte‐specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis

Xinqiang Huang, Chundong Yu, C. Jin, Chaofeng Yang, Rui Xie, Dongdong Cao, Fen Wang, W. Mckeehan

Molecular Carcinogenesis

DOI

2005

Independent Repression of Bile Acid Synthesis and Activation of c-Jun N-terminal Kinase (JNK) by Activated Hepatocyte Fibroblast Growth Factor Receptor 4 (FGFR4) and Bile Acids*

Chundong Yu, Fen Wang, C. Jin, Xinqiang Huang, W. Mckeehan

Journal of Biological Chemistry

DOI

2003

Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.

Chundong Yu, Fen Wang, C. Jin, Xinqiang Huang, D. Miller, C. Basilico, W. Mckeehan

American Journal of Pathology

DOI

2002

Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.

Chundong Yu, Fen Wang, C. Jin, Xiao-Chong Wu, Wai-Kin Chan, W. Mckeehan

American Journal of Pathology

DOI

2002

The heparan sulfate-fibroblast growth factor signaling system in liver growth and function

Chundong Yu

2000

Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4*

Chundong Yu, Fen Wang, M. Kan, C. Jin, R. B. Jones, M. Weinstein, Chu-Xia Deng, W. Mckeehan

Journal of Biological Chemistry

DOI

精选作品

期刊论文

Integrated Network Pharmacology, Transcriptomics, and Experimental Validation Identify PI3K-AKT and STAT3 as Key Pathways for Pien Tze Huang Against Liver and Colorectal Cancers

Yindan-Pinggan Capsules Alleviate Steatotic Liver Disease Through Modulating Multiple Signaling Pathways in Mice

Yindan Pinggan Capsule Suppresses Hepatocellular Carcinoma Proliferation via TGR5-mediated Dual Inhibition of YAP and Hedgehog Pathways

Histone Demethylase JMJD2D Suppresses Influenza A Virus Infection by Promoting RIG-I Expression

The JMJD family histone demethylases: structure, mechanism of action, diseases and therapeutic targets

Histone demethylase JMJD2D promotes macrophage IL-12b expression and contributes to host defense against Listeria monocytogenes infection

Histone demethylase JMJD1A protects mice from enteric bacterial infection by upregulating CCL8 expression to recruit macrophages and CD4+ T cells

ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion

Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP‐9

Targeting Nuclear Receptor Coactivator SRC‐1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD‐L1

The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis

Abstract 1688: Nuclear receptor coactivator SRC-1 promotes colorectal cancer immune escape by enhancing PD-L1 transcription and protein stability

Downregulation of Brf1 Induces Liver Failure and Inhibits Hepatocellular Carcinoma Progression by Promoting Apoptosis

Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression

Traditional Chinese medicine Pien-Tze-Huang ameliorates LPS-induced sepsis through bile acid-mediated activation of TGR5-STAT3-A20 signalling

JMJD2D stabilises and cooperates with HBx protein to promote HBV transcription and replication

Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells

Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling

Traditional Chinese Medicine Pien-Tze-Huang Inhibits Colorectal Cancer Growth and Immune Evasion by Reducing β-catenin Transcriptional Activity and PD-L1 Expression

Nuclear receptor coactivator SRC-1 promotes colorectal cancer progression through enhancing GLI2-mediated Hedgehog signaling

Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers

SRC-3 deficiency protects host from Listeria monocytogenes infection through increasing ROS production and decreasing lymphocyte apoptosis.

Steroid Receptor Coactivator-3 Is Required for Inhibition of the Intestinal Muscularis Inflammatory Response of Postoperative Ileus in Mice

Correction to: Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

肝肠循环因子FGF15/19调节胆汁酸代谢从而控制肝脏尺寸大小与肝癌发生

Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression

Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling

Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression

Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression

Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice.

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.

Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation

Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling

SRC-3 protects intestine from DSS-induced colitis by inhibiting inflammation and promoting goblet cell differentiation through enhancement of KLF4 expression

731 - Histone Demethylase JMJD2D Promotes Colorectal Cancer Progression through Enhancement of WNT/B-Catenin Pathway

Roles of Steroid Receptor Coactivator 3 in Host Defense Against Bacterial Pathogens.

Steroid receptor coactivator 3 contributes to host defense against enteric bacteria by recruiting neutrophils via upregulation of CXCL2 expression

E3 ubiquitin ligase FBW7α inhibits cholangiocarcinoma cell proliferation by downregulating c-Myc and cyclin E.

Histone acetyl transferase GCN5 promotes human hepatocellular carcinoma progression by enhancing AIB1 expression

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria

Downregulation of amplified in breast cancer 1 contributes to the anti-tumor effects of sorafenib on human hepatocellular carcinoma

Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/β-Catenin Signaling*

Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator not only for steroid receptors, such as androgen receptor and estrogen receptor, but also for other transcription factors. SRC-1 has been shown to play an important role in the p

Amplified in breast cancer 1 promotes colorectal cancer progression through enhancing Notch signaling

Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway.

[Down-regulation of TSPO expression doesn't affect the productions of TNF-α, IL-1β and IL-6 in LPS-stimulated BV-2 microglia].

Mycoepoxydiene inhibits antigen-stimulated activation of mast cells and suppresses IgE-mediated anaphylaxis in mice

Hepatitis B virus X protein stabilizes amplified in breast cancer 1 protein and cooperates with it to promote human hepatocellular carcinoma cell invasiveness

Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways

TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

Soluble FGFR4 extracellular domain inhibits FGF19-induced activation of FGFR4 signaling and prevents nonalcoholic fatty liver disease.

Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis

SRC-3 is required for clearing bacteria and repressing inflammatory response in Escherichia coli-induced septic peritonitis

Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology

Abstract 3093: Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness

Overexpression of transcriptional coactivator AIB1 promotes hepatocellular carcinoma progression by enhancing cell proliferation and invasiveness

FGFR4对胆汁酸代谢的调控作用

An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response.

Ectopic activity of fibroblast growth factor receptor 1 in hepatocytes accelerates hepatocarcinogenesis by driving proliferation and vascular endothelial growth factor-induced angiogenesis.

Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3.

Forced expression of hepatocyte‐specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis

Independent Repression of Bile Acid Synthesis and Activation of c-Jun N-terminal Kinase (JNK) by Activated Hepatocyte Fibroblast Growth Factor Receptor 4 (FGFR4) and Bile Acids*

Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis.

Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.

The heparan sulfate-fibroblast growth factor signaling system in liver growth and function

Elevated Cholesterol Metabolism and Bile Acid Synthesis in Mice Lacking Membrane Tyrosine Kinase Receptor FGFR4*

会议论文

Steroid receptor coactivator 1 promotes liver cancer progressionby enhancing cell proliferation and invasion

Role of steroid receptor coactivator 3 in bacterial colitis

Sorafenib promotes Hepatocellular carcinoma cells apoptosis by down regulating AIB1 protein expression

SRC-3 promotes colorectal cancer progression by enhancing Notch signaling

Role of AIB1 in Hepatocellular Carcinoma

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