张云武

2026

Vespakinin-M delineates an AMPK/mTOR-arginine-TCA cycle axis to act as an immunometabolic switch in post-stroke microglia

Redox Biology

DOI

2026

Astrocytic PYGM attenuates tau pathology by promoting lactate‐mediated neuroprotection

Alzheimer's & Dementia

DOI

2026

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Alzheimer's & Dementia

DOI

2026

The role of astrocytes in autism spectrum disorder and associated syndromes: Evidence, animal models, mechanisms, and therapeutic potential

Zoological Research

DOI

2026

MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants.

Molecular Psychiatry

DOI

2026

A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder

Cell Reports Medicine

DOI

2026

TMEM59 modulates TREM2-regulated microglial responses in ischemia and serves as a potential therapeutic target

Cell Death and Disease

DOI

2025

Soluble CSF1R alleviates microgliopathy in a CSF1R-related leukoencephalopathy (CRL) mouse model

Journal of Neuroinflammation

DOI

2025

Cell Adhesion Molecule Protocadherin-γC5 Ameliorates Aβ Plaque Pathogenesis by Modulating Astrocyte Function in Alzheimer's Disease

Journal of Neuroscience

DOI

2025

TMEM59 deficiency activates chaperone‐mediated autophagy and ameliorates disease‐like pathologies in tauopathy model mice

Alzheimer's & Dementia

DOI

2025

RPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism

Theranostics

DOI

2025

Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders.

Science Translational Medicine

DOI

2025

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies

Acta Pharmaceutica Sinica B

DOI

2025

FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway.

Neurobiology of Disease

DOI

2025

Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice

PLoS Biology

DOI

2025

CD2AP in Alzheimer's disease: Key mechanisms and therapeutic potential

Brain Medicine

DOI

2025

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy

Translational Psychiatry

DOI

2024

小胶质细胞介导的神经炎症和突触修剪参与自闭症谱系障碍的研究进展

《厦门大学学报(自然科学版)》

2024

Evaluation of Soluble Colony Stimulating Factor 1 Receptor (CSF1R) in Peripheral Blood as a Diagnostic Marker of CSF1R‐Related Disorder (CSF1R‐RD) in a Murine Model and CSF1R‐RD Patients

Annals of Neurology

DOI

2024

Synaptic adhesion molecule protocadherin‐γC5 mediates β‐amyloid‐induced neuronal hyperactivity and cognitive deficits in Alzheimer's disease

Journal of Neurochemistry

DOI

2024

P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting p-tau217 with immunotherapy ameliorates murine tauopathy.

Neuron

DOI

2024

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

iScience

DOI

2024

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

Molecular Neurodegeneration

DOI

2024

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis.

Neuron

DOI

2024

Ketogenic β‐hydroxybutyrate regulates β‐hydroxybutyrylation of TCA cycle‐associated enzymes and attenuates disease‐associated pathologies in Alzheimer's mice

Aging Cell

DOI

2024

Targeting synaptic pathology in Alzheimer’s disease

Zoological Research

DOI

2024

Microglial Dysfunction in Autism Spectrum Disorder

The Neuroscientist

DOI

2023

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Journal of Neuroinflammation

DOI

2023

TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance.

International Immunopharmacology

DOI

2023

Loss of RAB39B does not alter MPTP-induced Parkinson’s disease-like phenotypes in mice

Frontiers in Aging Neuroscience

DOI

2023

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice

Journal of Cellular and Molecular Medicine

DOI

2023

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling.

Brain, behavior, and immunity

DOI

2023

Long-term potentiation-based screening identifies neuronal PYGM as a synaptic plasticity regulator participating in Alzheimer’s disease

Zoological Research

DOI

2023

Tau reduction attenuates autism-like features in Fmr1 knockout mice

Molecular Autism

DOI

2023

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration.

Immunity

DOI

2022

Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice

Journal of Neuroscience

DOI

2022

Pedigree-based study to identify GOLGB1 as a risk gene for bipolar disorder

Translational Psychiatry

DOI

2022

Correction to: SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

Molecular Neurobiology

DOI

2022

Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Molecular Therapy: Methods & Clinical Development

DOI

2022

Phenazopyridine promotes RPS23RG1/Rps23rg1 transcription and ameliorates Alzheimer-associated phenotypes in mice

Neuropsychopharmacology

DOI

2021

《中国应对阿尔茨海默病战略行动计划》建议书

《阿尔茨海默病及相关病杂志》

2021

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Journal of Neuroinflammation

DOI

2021

SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

National Science Review

DOI

2021

A Novel CNTNAP2 Mutation Results in Abnormal Neuronal E/I Balance

Frontiers in Neurology

DOI

2021

Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice

Frontiers in Cell and Developmental Biology

DOI

2021

Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

Frontiers in Aging Neuroscience

DOI

2021

Proteolytic Shedding of Human Colony‐Stimulating Factor 1 Receptor and its implication

Journal of Cellular and Molecular Medicine

DOI

2021

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival

Frontiers in Immunology

DOI

2020

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Biological Psychiatry，Vol. 87, No. 8

DOI

2020

CD2AP在阿尔茨海默病发病进程中作用的研究进展

《阿尔茨海默病及相关病杂志》

2020

Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss‐of‐function murine models

The FASEB Journal

DOI

2020

Phenolic glycosides from the roots of Ficus hirta Vahl. and their anti-neuroinflammatory activities.

Journal of Agricultural and Food Chemistry

DOI

2020

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Cell Death and Differentiation

DOI

2020

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

Cell Death and Disease

DOI

2020

TMEM59 Haploinsufficiency Ameliorates the Pathology and Cognitive Impairment in the 5xFAD Mouse Model of Alzheimer’s Disease

Frontiers in Cell and Developmental Biology

DOI

2020

Overexpression of Human SNX27 Enhances Learning and Memory Through Modulating Synaptic Plasticity in Mice

Frontiers in Cell and Developmental Biology

DOI

2020

RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy

Frontiers in Cell and Developmental Biology

DOI

2020

Apolipoprotein E4 expressed by microglia impairs microglial functions and enhances neurotoxicity

DOI

2020

A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease

ACS Nano

DOI

2019

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Frontiers in Cellular Neuroscience

DOI

2019

Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway

Frontiers in Aging Neuroscience

DOI

2019

A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II

Experimental and Molecular Medicine

DOI

2019

Silencing MicroRNA-155 Attenuates Kainic Acid-Induced Seizure by Inhibiting Microglia Activation

Neuroimmunomodulation

DOI

2018

Role of Rab GTPases in Alzheimer's Disease.

ACS Chemical Neuroscience

DOI

2018

Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression

Cell Reports

DOI

2018

Protective Role of L-3-n-Butylphthalide in Cognitive Function and Dysthymic Disorders in Mouse With Chronic Epilepsy

Frontiers in Pharmacology

DOI

2018

Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model

Front. Neural Circuits

DOI

2018

RPS23RG1 is Required for Synaptic Integrity and Rescues Alzheimer’s Associated Cognitive Deficits

Biological Psychiatry

DOI

2018

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Frontiers in Aging Neuroscience

DOI

2017

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Journal of Neuroscience

DOI

2017

Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease

Journal of Neuroscience

DOI

2017

A novel presenilin 1 mutation (F388L) identified in a Chinese family with early-onset Alzheimer's disease.

Neurobiology of Aging

DOI

2017

Intracellular trafficking of TREM2 is regulated by presenilin 1

Experimental and Molecular Medicine

DOI

2017

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Journal of Experimental Medicine

DOI

2017

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease

Chinese Medical Journal

DOI

2016

SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Journal of Neuroscience

DOI

2016

Opposing Roles of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and TREM-like Transcript 2 (TREML2) in Microglia Activation

Neurobiology of Aging

DOI

2016

VPS35 regulates cell surface recycling and signaling of dopamine receptor D1

Neurobiology of Aging

DOI

2016

Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway.

Bioorganic & Medicinal Chemistry Letters

DOI

2016

RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits

Scientific Reports

DOI

2016

The Neuron-Specific Protein TMEM59L Mediates Oxidative Stress-Induced Cell Death

Molecular Neurobiology

DOI

2016

Protective role of miR-23b-3p in kainic acid-induced seizure

NeuroReport

DOI

2016

Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology

Journal of Cell Science

DOI

2016

Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice.

Neuropharmacology

DOI

2015

Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells

Acta Pharmacologica Sinica

DOI

2015

Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation.

Neurobiology of Aging

DOI

2015

The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Journal of Neuroscience

DOI

2015

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Molecular Neurodegeneration

DOI

2015

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Neuron

DOI

2015

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation

PLoS ONE

DOI

2015

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response*

Journal of Biological Chemistry

DOI

2015

SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation

Molecular Neurobiology

DOI

2014

M1 muscarinic acetylcholine receptor in Alzheimer’s disease

Neuroscience Bulletin

DOI

2014

Trafficking regulation of proteins in Alzheimer’s disease

Molecular Neurodegeneration

DOI

2014

MiR-219 Protects Against Seizure in the Kainic Acid Model of Epilepsy

Molecular Neurobiology

DOI

2014

Structural Bioinformatics‐Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE

Chemical Biology and Drug Design

DOI

2014

Sorting Nexin 27 Regulates Aβ Production through Modulating γ-secretase Activity

Cell Reports

DOI

2014

The γ-secretase complex: from structure to function

Frontiers in Cellular Neuroscience

DOI

2013

A novel mechanism underlying pathogenesis of Down syndrome

Molecular Neurodegeneration

DOI

2013

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival

PLoS ONE

DOI

2013

Insufficient ER-stress response causes selective mouse cerebellar granule cell degeneration resembling that seen in congenital disorders of glycosylation

Molecular Brain

DOI

2013

Transcriptional regulation and its misregulation in Alzheimer’s disease

Molecular Brain

DOI

2013

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down syndrome

Nature Medicine

DOI

2013

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

Neuroscience Letters

DOI

2013

Novel Pathways Regulating Function and Metabolism of ß-Amyloid Precursor Protein in Alzheimer's Disease

DOI

2012

Alzheimer’s β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

Journal of Neuroscience

DOI

2012

Appoptosin is a Novel Proapoptotic Protein and Mediates Cell Death in Neurodegeneration

Journal of Neuroscience

DOI

2012

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms*♦

Journal of Biological Chemistry

DOI

2012

CutA Divalent Cation Tolerance Homolog (Escherichia coli) (CUTA) Regulates β-Cleavage of β-Amyloid Precursor Protein (APP) through Interacting with β-Site APP Cleaving Protein 1 (BACE1)*

Journal of Biological Chemistry

DOI

2012

Identifying an APP-binding protein in neuronal cell death

Molecular Neurodegeneration

DOI

2012

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Molecular Neurodegeneration

DOI

2012

M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation

Neuroscience Letters

DOI

2011

Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway

Neurobiology of Aging

DOI

2011

SNX12 Affects Aβ Generation Through Regulating Subcellular Localization of BACE1

2011

Mechanism Underlying the Brain-specific Membrane-anchored Protein TMEM59L-mediated Apoptosis

2011

Differential regulation of BACE1 expression by oxidative and nitrosative signals

Molecular Neurodegeneration

DOI

2011

APP processing in Alzheimer's disease

Molecular Brain

DOI

2011

P3‐174: Roles of SNX family members in neurodegenerative diseases

DOI

2011

Proteolytic processing of Alzheimer’s β-amyloid precursor protein

Journal of Neurochemistry

DOI

2011

The Apoptosis Induced by FAM105A Through Bcl-2 Family and Caspase Dependent Pathway

2010

P2‐312: The Rps23r1 gene family regulates Alzheimer's beta‐amyloid generation and tau phosphorylation

DOI

2010

P2‐213: Appoptosin interacts with amyloid precursor protein and mediates neuronal toxicity via caspase depended pathway

DOI

2010

The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.

Human Molecular Genetics

DOI

2010

Substrate check of γ-secretase

Nature Structural &Molecular Biology

DOI

2009

Retinoid X receptor-α mediates (R)-flurbiprofen’s effect on the levels of Alzheimer’s β–amyloid

Journal of Neurochemistry

DOI

2009

p53-dependent control of transactivation of the Pen2 promoter by presenilins

Journal of Cell Science

DOI

2009

Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1*

Journal of Biological Chemistry

DOI

2009

A Functional Mouse Retroposed Gene Fg01 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation

Neuron

DOI

2009

Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China

Molecular Neurodegeneration

DOI

2008

β-淀粉样蛋白前体蛋白胞内结构域(AICD)研究进展

《生命科学》

2008

Presenilins regulate the cellular level of the tumor suppressor PTEN.

Neurobiology of Aging

DOI

2008

Advances in understanding the β-amyloid precursor protein intracellular domain

2007

Alteration of β-secretase traffic by the receptor tyrosine kinase signaling pathway – a new mechanism for regulating Alzheimer's β-amyloid production

Cell Research

DOI

2007

Erratum: Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo (Journal of Neurochemistry (2007) 102, (619-626))

DOI

2007

Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression

Proceedings of the National Academy of Sciences of the United States of America

DOI

2007

Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl‐terminal fragments in cerebral neurons in vivo

Journal of Neurochemistry

DOI

2007

Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism.

Current molecular medicine

DOI

2007

Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation*

Journal of Biological Chemistry

DOI

2006

O2–01–05: Tumor suppressor PTEN affects tau phosphorylation, aggregation and binding to microtubules

DOI

2006

Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau

Molecular Neurodegeneration

DOI

2006

Transcriptional regulation of APH‐1A and increased γ‐secretase cleavage of APP and Notch by HIF‐1 and hypoxia

The FASEB Journal

DOI

2006

Calnuc binds to Alzheimer’s β‐amyloid precursor protein and affects its biogenesis

Journal of Neurochemistry

DOI

2006

S4–03–01: Evidence that aberrant post–TGN trafficking of Alzheimer's APP is sufficient to elevate brain A–beta 42 and may underlie mutant presenilin action

DOI

2006

Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB

Molecular and Cellular Biology

DOI

2006

Tumor suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules

The FASEB Journal

DOI

2006

Estrogen, β‐Amyloid Metabolism/Trafficking, and Alzheimer's Disease

Annals of the New York Academy of Sciences

DOI

2006

P1–298: Differential transcriptional regulation of PEN–2 and APH–1A, two key components of the gamma–secretase complex

DOI

2006

Pathological and physiological functions of presenilins

Molecular Neurodegeneration

DOI

2005

Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation

Journal of Neuroscience

DOI

2005

Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components*

Journal of Biological Chemistry

DOI

2004

Presenilins and γ-Secretase Inhibitors Affect Intracellular Trafficking and Cell Surface Localization of the γ-Secretase Complex Components*

Journal of Biological Chemistry

DOI

2024

CD2AP通过TRIM5介导的NF-κB信号促进胶质母细胞瘤恶性发展的研究

《第十八届中国医师协会神经外科医师年会摘要集-基础研究》

DOI

2017

参与认知相关新基因的功能研究

《中国神经科学学会第十二届全国学术会议》