史西保｜河南师范大学｜学者主页

2026

PRRSV-induced glucose-6-phosphate transporter promotes viral replication by suppressing type I interferon transcription

Xibao Shi, Keqi Wang, Yuyao Wang, Siyu Peng, L Wang, Hao Chen, Xiaozhuan Zhang, Aiping Wang, Gaiping Zhang

Microbial Pathogenesis

2026

Nuclear factor IC promoting porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppressing type I interferon transcription

Xibao Shi, Huifeng Chen, Yuqi Xing, Keqi Wang, X. Zhang, Xiaomin Fan, Ying Zhang, Yuyao Wang, Siyu Peng, A R Wang, Gaiping Zhang

BMC Veterinary Research

DOI

2025

Nuclear factor IX could facilitate porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppresses retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR-3)-mediated type I interferon transcription

Xibao Shi, Yuqi Xing, Hao Chen, Keqi Wang, Xiaozhuan Zhang, Xiaomin Fan, Ying Zhang, Yuyao Wang, Yuyao Wang, Siyu Peng, Aiping Wang, Gaiping Zhang

Microbial Pathogenesis

DOI

2024

IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner

Xibao Shi, Menglu Wei, Menglu Wei, Yuwen Feng, Yuwen Feng, Yuanhao Yang, Xiaozhuan Zhang, Hao Chen, Yuqi Xing, Keqi Wang, Aiping Wang, Li Wang, Aiping Wang, Gaiping Zhang, Gaiping Zhang

DNA and Cell Biology

DOI

2022

miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7

Xibao Shi, Yuanhao Yang, Xiaozhuan Zhang, Xiaobo Chang, Jing Chen, Chao Wang, Aiping Wang, Jianhua Wang, Jianru Qin, Xianlong Ye, Wei Jin, Gaiping Zhang

Viruses

DOI

2020

PRRSV GP2a胞外区的原核表达及免疫原性分析

扣莉云，张改平，史西保，张小转，车志芬，周景明，祁艳华，王爱萍

《中国兽医学报》

2020

核因子I/A(NFIA)依赖其N末端的DNA结合结构域抑制猪繁殖与呼吸综合征病毒(PRRSV)复制

赵旭阳，史西保，张小转，陈静，王丽，邓瑞广，张改平

《中国兽医学报》

2020

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

Xiaobo Chang, Xibao Shi, Xiaozhuan Zhang, Jing Chen, Xiaomin Fan, Yuanhao Yang, Li Wang, Aiping Wang, Ruiguang Deng, En‐Min Zhou, Gaiping Zhang

The FASEB Journal

DOI

2019

甲基-CpG结合结构域蛋白2抑制PRRSV复制的研究

赵慧君，赵旭阳，史西保，陈静，范小敏，王丽，李青梅，常晓博，邓瑞广，张改平

《河南农业大学学报》

DOI

2019

IFI16 Inhibits Porcine Reproductive and Respiratory Syndrome Virus 2 Replication in a MAVS-Dependent Manner in MARC-145 Cells

Xiaobo Chang, Xibao Shi, Xiaozhuan Zhang, Li Wang, Xuewu Li, Aiping Wang, Ruiguang Deng, En‐Min Zhou, Gaiping Zhang

Viruses

DOI

2019

Identification of a linear B-cell epitope on glycoprotein (GP) 2a of porcine reproductive and respiratory syndrome virus (PRRSV)

Xibao Shi, Xiaomin Fan, Shouyi Nie, Liyun Kou, Xiaozhuan Zhang, Hongliang Liu, Shengdong Ji, Ruiguang Deng, Aiping Wang, Gaiping Zhang

International Journal of Biological Macromolecules

DOI

2017

猪繁殖与呼吸综合征病毒BJ-4株GP4蛋白的原核表达与纯化

车志芬，史西保，张改平，扣莉云，周景明，祁艳华，王爱萍

《西北农林科技大学学报(自然科学版)》

2016

MicroRNA 373 Facilitates the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Its Negative Regulation of Type I Interferon Induction

Jing Chen, Xibao Shi, Xiaozhuan Zhang, Aiping Wang, Li Wang, Yanyan Yang, Ruiguang Deng, Gaiping Zhang

Journal of Virology

DOI

2016

Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells

Xibao Shi, Xiaozhuan Zhang, Yongzhe Chang, Bo Jiang, Ruiguang Deng, Aiping Wang, Gaiping Zhang

BMC Veterinary Research

DOI

2015

猪繁殖与呼吸综合征病毒非结构蛋白1α(nsp1α)的N端锌指结构是其抑制NLRP3炎症小体活性所必需

王超，史西保，王丽，陈静，司朝朝，王爱萍，邓瑞广，张改平

《畜牧兽医学报》

2015

猪繁殖与呼吸障碍综合征病毒非结构蛋白nsp1α的表达及活性检测

司朝朝，史西保，李恭贺，乔松林，王丽，李青梅，王超，陈静，王寅彪，张改平

《河南农业科学》

2015

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2

Jing Chen, Xibao Shi, Xiaozhuan Zhang, Li Wang, Jun Luo, Guangxu Xing, Ruiguang Deng, Hong Yang, Jinting Li, Aiping Wang, Gaiping Zhang

Viruses

DOI

2015

The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1β Induction

Chao Wang, Xibao Shi, Xiaozhuan Zhang, Aiping Wang, Li Wang, Jing Chen, Ruiguang Deng, Gaiping Zhang

DNA and Cell Biology

DOI

2015

Small interfering RNA targeting nonstructural protein1 α (nsp1α) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells

Xibao Shi, Yongzhe Chang, Xiaozhuan Zhang, Li Wang, Chunxi Li, Kai Jiang, Jing Chen, Chao Wang, Ruiguang Deng, Jianming Fan, Gaiping Zhang

Research in Veterinary Science

DOI

2014

猪繁殖与呼吸综合征病毒（PRRSV）非结构蛋白（nsp）1α抑制β干扰素转录的分子机理研究

史西保

《河南农业大学》

2014

稳定表达靶向BVDV shRNA细胞系的建立及其对BVDV复制的影响

范璐，王丽，史西保，樊剑鸣，王爱萍，张改平

《河南农业科学》

2013

The Zinc-Finger Domain Was Essential for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein-1α to Inhibit the Production of Interferon-β

Xibao Shi, Xiaozhuan Zhang, Fang-Yu Wang, Li Wang, S. Qiao, Jun-Qing Guo, C. Luo, Bo Wan, R. Deng, Gaiping Zhang

Journal of Interferon and Cytokine Research

DOI

2013

Antibody-dependent enhancement of PRRSV infection down-modulates TNF-α and IFN-β transcription in macrophages.

D. Bao, Rui Wang, S. Qiao, Bo Wan, Yin-Biao Wang, Mingyang Liu, Xibao Shi, J. Guo, Gaiping Zhang

Veterinary Immunology and Immunopathology

DOI

2012

Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1α (nsp1α) as an inhibitor to the induction of IFN-β.

Xibao Shi, Jing Chen, G. Xing, Xiaozhuan Zhang, Xiao-Fei Hu, Yu-Bao Zhi, Jun-Qing Guo, Li Wang, S. Qiao, Qingxia Lu, Gaiping Zhang

Cellular Immunology

DOI

2012

Development of an immunochromatographic strip for rapid detection of antibodies against classical swine fever virus.

Xuewu Li, Li Wang, Xibao Shi, Dong Zhao, Ji-Fei Yang, Suzhen Yang, Gaiping Zhang

Journal of Virological Methods

DOI

2011

PRRSV河南株ORF7基因的克隆表达及条件优化

刘明，张改平，肖治军，郭军庆，乔松林，王丽，史西保，刘运超，游雷鸣，王爱萍

《河南农业科学》

2011

Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction

Xibao Shi, Li Wang, Xuewu Li, Gaiping Zhang, Jun-Qing Guo, Dong Zhao, Shu-Jun Chai, R. Deng

Molecular Immunology

DOI

2011

The Nonstructural Protein 1 Papain-Like Cysteine Protease Was Necessary for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 to Inhibit Interferon-β Induction

Xibao Shi, Gaiping Zhang, Li Wang, Xuewu Li, Yu-Bao Zhi, Fang-Yu Wang, Jianming Fan, R. Deng

DNA and Cell Biology

DOI

2010

猪伪狂犬病毒的增殖、纯化和鉴定

王大伟，李学伍，王丽，史西保

《河南农业科学》

2010

Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells

Xibao Shi, Li Wang, Yu-Bao Zhi, G. Xing, Dong Zhao, R. Deng, Gai-Ping Zhang

Virus Research

DOI

2010

Identification and Purification of Pseudorabies Virus Proliferated in BHK-21 Cells

Da-Wei Wang, Xuewu Li, Li Wang, Xibao Shi

史西保

精选作品

期刊论文

PRRSV-induced glucose-6-phosphate transporter promotes viral replication by suppressing type I interferon transcription

Nuclear factor IC promoting porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppressing type I interferon transcription

Nuclear factor IX could facilitate porcine reproductive and respiratory syndrome virus (PRRSV) replication and suppresses retinoic acid-inducible gene I (RIG-I) and toll-like receptor 3 (TLR-3)-mediated type I interferon transcription

IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner

miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7

PRRSV GP2a胞外区的原核表达及免疫原性分析

核因子I/A(NFIA)依赖其N末端的DNA结合结构域抑制猪繁殖与呼吸综合征病毒(PRRSV)复制

miR‐382‐5p promotes porcine reproductive and respiratory syndrome virus (PRRSV) replication by negatively regulating the induction of type I interferon

甲基-CpG结合结构域蛋白2抑制PRRSV复制的研究

IFI16 Inhibits Porcine Reproductive and Respiratory Syndrome Virus 2 Replication in a MAVS-Dependent Manner in MARC-145 Cells

Identification of a linear B-cell epitope on glycoprotein (GP) 2a of porcine reproductive and respiratory syndrome virus (PRRSV)

猪繁殖与呼吸综合征病毒BJ-4株GP4蛋白的原核表达与纯化

MicroRNA 373 Facilitates the Replication of Porcine Reproductive and Respiratory Syndrome Virus by Its Negative Regulation of Type I Interferon Induction

Nonstructural protein 11 (nsp11) of porcine reproductive and respiratory syndrome virus (PRRSV) promotes PRRSV infection in MARC-145 cells

猪繁殖与呼吸综合征病毒非结构蛋白1α(nsp1α)的N端锌指结构是其抑制NLRP3炎症小体活性所必需

猪繁殖与呼吸障碍综合征病毒非结构蛋白nsp1α的表达及活性检测

Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Inhibits RNA-Mediated Gene Silencing by Targeting Ago-2

The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1β Induction

Small interfering RNA targeting nonstructural protein1 α (nsp1α) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells

猪繁殖与呼吸综合征病毒（PRRSV）非结构蛋白（nsp）1α抑制β干扰素转录的分子机理研究

稳定表达靶向BVDV shRNA细胞系的建立及其对BVDV复制的影响

The Zinc-Finger Domain Was Essential for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein-1α to Inhibit the Production of Interferon-β

Antibody-dependent enhancement of PRRSV infection down-modulates TNF-α and IFN-β transcription in macrophages.

Amino acid at position 176 was essential for porcine reproductive and respiratory syndrome virus (PRRSV) non-structural protein 1α (nsp1α) as an inhibitor to the induction of IFN-β.

Development of an immunochromatographic strip for rapid detection of antibodies against classical swine fever virus.

PRRSV河南株ORF7基因的克隆表达及条件优化

Endoribonuclease activities of porcine reproductive and respiratory syndrome virus nsp11 was essential for nsp11 to inhibit IFN-β induction

The Nonstructural Protein 1 Papain-Like Cysteine Protease Was Necessary for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 to Inhibit Interferon-β Induction

猪伪狂犬病毒的增殖、纯化和鉴定

Porcine reproductive and respiratory syndrome virus (PRRSV) could be sensed by professional beta interferon-producing system and had mechanisms to inhibit this action in MARC-145 cells

Identification and Purification of Pseudorabies Virus Proliferated in BHK-21 Cells

研究方向