齐琦｜暨南大学｜学者主页

2026

基于斑马鱼模型和网络药理学探讨积雪草酸对MASLD的作用及潜在机制

唐运妮，陈敏华，幸尚平，黄菊，张校熔，杨金妮，韦智译，齐琦，何萍

《右江民族医学院学报》

2026

NONHSAT001931 ceRNA轴可能在高级别鳞状上皮内病变向宫颈癌进展中发挥调控作用

马月月，刁伟华，李琦，孙宇虹，何雨萱，齐琦，赵卫红

《中国生物化学与分子生物学报》

2026

Dual inhibition of glycolysis and glutaminolysis by targeting FOXO3 for hepatocellular carcinoma treatment

Fan Wang, Meng Huang, Kaixuan Sheng, Yue Yan, Beibei Zhang, Xinlei Wang, Zhi-Yi Yang, Meng-Yue Li, Yuping Liu, Qi Qi, Yue-Jun Sun, Cheng-Lin Li

Oncogene

DOI

2026

GDPPH1 induces cell cycle arrest by downregulation of CDK4/Cyclin D1 via the m6A-METTL14-YTHDF2 axis, attenuating glioblastoma progression

S Li, Ruijie Yuan, Jinxuan Su, Ruxi Chen, Xinyi Qu, Lele Zhao, Xiaofeng Zhou, Qiuming Zou, Z Zhang, Siyu Yang, Jianqin Lai, Xiao-song Zhuang, Zisheng Li, Kai Cui, Shengwei Hu, Yongqi Liu, Lili Liu, Zepeng Luo, Zhongping Luo, Wen Li, Yu Yan, Yubo Zhang, Zhiming Zheng, Qi Qi

Cell Death and Disease

DOI

2025

Sulforaphane: An emerging star in neuroprotection and neurological disease prevention

Na Wu, Zepeng Luo, Zepeng Luo, Renfu Deng, Zhijing Zhang, Jichun Zhang, Songlin Liu, Zhongping Luo, Zhongping Luo, Qi Qi

Biochemical Pharmacology

DOI

2025

Correction to: Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan, Keqiang Ye

Cell Death and Disease

DOI

2025

Correction: 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Changliang Shan, Zhaoliang Lu, Zhen Li, Hao Sheng, Jun Fan, Qi Qi, Shuangping Liu, Shuai Zhang

Cell Death and Disease

DOI

2025

Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy

Zeyuan Yin, Shi-min He, Xinyuan Zhang, Xiaochen Yu, Kai-xuan Sheng, Tong Fu, Yi-xue Jiang, Xu Liu, Bing-xuan Hu, Jingbo Zhang, Yan-yu Li, Qing Wang, Beibei Zhang, Yun-meng Qi, Joseph Adu‐Amankwaah, Xueyan Zhou, Qi Qi, Bei Zhang, Chenglin Li

Acta Pharmacologica Sinica

DOI

2025

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Lei Huang, Yalei Wen, Qin Guo, Caishi Zhang, Xiao Yang, Mei Li, YiXia Liu, Xinying Li, Jiaxin Tang, Xiaofeng Zhou, Qi Qi, Haoxing Zhang, Tongzheng Liu

Cell Death and Disease

DOI

2024

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

Qiu-ming Zou, Xiaofeng Zhou, Jianqin Lai, Haixia Zhou, Jinxuan Su, Zhijing Zhang, Xiao-song Zhuang, Lili Liu, Ruijie Yuan, Sijia Li, Siyu Yang, Xinyi Qu, Jiezhu Feng, Yongqi Liu, Zisheng Li, Shi‐Ting Huang, Zhi Shi, Yu Yan, Zhiming Zheng, Wen‐Cai Ye, Qi Qi

Redox Biology

DOI

2024

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

Jianqin Lai, Lele Zhao, Chao Hong, Qiu-ming Zou, Jin-xuan Su, Sijia Li, Xiaofeng Zhou, Zisheng Li, Bo Deng, Jie Cao, Qi Qi

Acta Pharmacologica Sinica

DOI

2023

18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype

Hanyue Luo, Caishi Zhang, Lujuan He, Zefang Lin, Ji-chun Zhang, Qi Qi, Jia-xu Chen, Wei Yao

Psychopharmacology，Vol. 2400, No. 9

DOI

2023

N-3, a novel synthetic derivative of bifendate, inhibits metastasis of triple-negative breast cancer via decreasing p38-regulated FOXC1 protein stability.

Fan Wang, Rong Liao, Xin Wang, Guixiang Xiong, Bei Zhang, Juan Li, Dengpan Wu, Yan Chen, Xueyan Zhou, Xiaoke Gu, Qi Qi, Chenglin Li

Biochemical Pharmacology

DOI

2023

Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies

Jin Su, Sijia Li, Xiaofeng Zhou, Zhi-jing Zhang, Yu Yan, Song-Lin Liu, Qi Qi

Acta Pharmacologica Sinica

DOI

2023

Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer

Chenxi Wang, Chenxi Yu, Hong-Kai Chang, Jiaqi Song, Shuai Zhang, Jianguo Zhao, Ji-Yan Wang, Tao Wang, Qi Qi, Changliang Shan

Expert opinion on therapeutic targets

DOI

2023

lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2.

Qing Wen, Mao-Hua Huang, Jingwen Xie, Runyu Liu, Qun Miao, Jin-Jun Huang, Jun-Qiu Zhang, Wenyu Lyu, Ming Qi, Chun-Yi Wu, Qi Qi, Zhijing Zhang, Rong Deng, Chenran Wang, Zhe-Sheng Chen, Dongmei Zhang, Wencai Ye, Minfeng Chen

Drug resistance updates

DOI

2023

ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy

Chenran Wang, Mao-Hua Huang, Yuning Lin, Yiming Zhang, Jinghua Pan, Chang Jiang, Min-Jing Cheng, Shen-Rong Li, Wen-Zhuo He, Zhengqiu Li, Zhengchao Tu, Jun Fan, Huhu Zeng, Jiahui Lin, Yong-Jin Wang, Nan Yao, Tong-Zheng Liu, Qi Qi, Xiangning Liu, Zhi-Min Zhang, Minfeng Chen, Liang-Ping Xia, Dongmei Zhang, Wen-Cai Ye

Nature Metabolism

DOI

2023

TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold‐Sensing TRPM8 Channel

Xiaobo Li, Qi Qi, Yong Li, Qun Miao, Wenqian Yin, Jing-Hua Pan, Zhan Zhao, Xiao-Ying Chen, Fan Yang, Xiaofeng Zhou, Mao-Hua Huang, Chenran Wang, Lijuan Deng, Dandan Huang, Ming Qi, Shuran Fan, Yiran Zhang, Shenghui Qiu, W. Deng, Tongzheng Liu, Minfeng Chen, Wencai Ye, Dongmei Zhang

Advancement of science

DOI

2023

Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin

Yanguan Guo, Jiaxin Tian, Yongjian Guo, Cong Wang, Congcong Chen, Songwang Cai, Wenliang Yu, Binghe Sun, Jin Yan, Zhonghua Li, Jun Fan, Qi Qi, Dongmei Zhang, Weilin Jin, Zichun Hua, Guo Chen

Cell Reports

DOI

2023

Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

Fang Wang, Qi Qi, Baifu Qin, Yiwei Wang, Youwei Huang, Qing Li, Xi Hua Shen, Xiangyu Wang, Shangqi Yang, Guopeng Pan, Jiahong Chen, Zixi Qin, Xueqin Chen, Yuqing Yang, Yuequan Zeng, Jun Liu, Yuqin Li, Ying Li, Zexiong Cheng, Xi Lin, Fan Xing, Yubo Zhang, Guo‐Cai Wang, Kai Li, Zhenyou Jiang, Haipeng Zhang

Cell Reports

DOI

2023

Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway

Geni Ye, Yubo Jiao, Lijuan Deng, Min-Jing Cheng, Sheng Wang, Junqiu Zhang, Jie Ouyang, Yong Hui Li, Yuxin He, Zhengchao Tu, Zhen Wang, Xiaojuan Song, Chenran Wang, Qi Qi, Dongmei Zhang, Lei Wang, Maohua Huang, Wen‐Cai Ye, Minfeng Chen

International Journal of Biological Sciences

DOI

2022

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

Wei Yao, Qianqian Cao, Shilin Luo, Lujuan He, Chun Yang, Jiaxu Chen, Qi Qi, Kenji Hashimoto, Ji-Chun Zhang

Molecular Psychiatry，Vol. 270, No. 30

DOI

2022

GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells

Yue Zhang, Yuxuan Song, Shuang Ren, Min-Qin Zhang, Zhao Zhang, Shuang-Qin Fan, Xing Liu, Xiaoyu Peng, Qi Qi, Xiangchun Shen, Yan Chen

Oncogene

DOI

2022

Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

Ming Qi, Shuran Fan, Mao-Hua Huang, Jing-Hua Pan, Yong Li, Qun Miao, Wenyu Lyu, Xiaobo Li, Lijuan Deng, Shenghui Qiu, Tongzheng Liu, Wei-Wei Deng, Xi Chu, Chang Jiang, Wen-Zhuo He, Liang-Ping Xia, Yun-Long Yang, Jian Hong, Qi Qi, Wenqian Yin, Xiangning Liu, Chang-Zheng Shi, Minfeng Chen, Wencai Ye, Dongmei Zhang

Journal of Clinical Investigation

DOI

2022

m6A modification: recent advances, anticancer targeted drug discovery and beyond

Lijuan Deng, Weilun Deng, Shunming Fan, Minfeng Chen, Ming Qi, Wen-Yu Lyu, Qi Qi, A. Tiwari, Jia-Xu Chen, Dong-Mei Zhang, Zhe-Sheng Chen

Molecular Cancer

DOI

2022

Novel TCF21 high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix

Xiaobo Li, Jinghua Pan, Tongzheng Liu, Wenqian Yin, Qun Miao, Zhan Zhao, Yufeng Gao, Wei Zheng, Hang Li, Rong Deng, Dandan Huang, Shenghui Qiu, Yiran Zhang, Qi Qi, Lijuan Deng, Maohua Huang, Patrick Ming‐Kuen Tang, Yihai Cao, Minfeng Chen, Wen‐Cai Ye, Dongmei Zhang

Gut

DOI

2021

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

Wei Yao, Song Lin, Jin Su, Qianqian Cao, Yueyue Chen, Jiaxu Chen, Zhentao Zhang, Kenji Hashimoto, Qi Qi, Ji-chun Zhang

Translational Psychiatry，Vol. 11, No. 10

DOI

2021

Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway

Maohua Huang, Mingqun Liu, Dandan Huang, Yanping Ma, Geni Ye, Qing Wen, Yong Li, Lijuan Deng, Qi Qi, Tongzheng Liu, Xiangning Liu, Minfeng Chen, Wen‐Cai Ye, Dongmei Zhang

Cancer Letters

DOI

2021

3′-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR

Pei Long, Yong Li, Qing Wen, Maohua Huang, Songtao Li, Yu‐Ning Lin, Xiao‐Jun Huang, Minfeng Chen, Jie Ouyang, Yun‐Lin Ao, Qi Qi, Haipeng Zhang, Wen‐Cai Ye, Guohua Cheng, Xiao‐Qi Zhang, Dongmei Zhang

Phytomedicine

DOI

2021

Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription

Rui Tang, Qianqian Cao, Sheng-wei Hu, Lujuan He, Pengfei Du, Gang Chen, Rao Fu, Fei Xiao, Yirong Sun, Ji‐chun Zhang, Qi Qi

Acta Pharmacologica Sinica

DOI

2021

Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer

Zhen Li, Jin Su, Mingming Sun, Jiaqi Song, Huanran Sun, Jun Fan, Guo Chen, Changliang Shan, Qi Qi, Shuai Zhang

Molecular and Cellular Biochemistry

DOI

2021

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

Chenglin Li, Juan Li, Shuyuan Gong, Meng Huang, Rui Li, Guixiang Xiong, Fan Wang, Qiu-ming Zou, Qi Qi, Xiaoxing Yin

Acta Pharmacologica Sinica

DOI

2021

Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

Minjie Zhang, Jiaxi Qu, Zhiwei Gao, Qi Qi, Hong Yin, Ling Zhu, Yi‐Chen Wu, Wei Liu, Jian Yang, Xuefeng Huang

Frontiers in Pharmacology

DOI

2020

Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment

Lijuan Deng, Yong Li, Ming Qi, Junshan Liu, Sheng Wang, Lijun Hu, Yuhe Lei, Ren‐Wang Jiang, Wei‐Min Chen, Qi Qi, Hai‐Yan Tian, Weili Han, Baojian Wu, Jiaxu Chen, Wen‐Cai Ye, Dongmei Zhang

European Journal of Pharmacology

DOI

2020

Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

Zhen Shu, Zhen Li, Huanhuan Huang, Yan Chen, Jun Fan, Li Yu, Zhihui Wu, Ling Tian, Qi Qi, Shuang Peng, Changyong Wei, Zhongqiu Xie, Xiaobo Li, Qi Feng, Hao Sheng, Guangqiang Li, Dongping Wei, Changliang Shan, Guo Chen

Oncogene

DOI

2019

Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid

Xiaosu Li, Xueyi Tang, Jin Su, Guofang Xu, Limin Zhao, Qi Qi

Biochemical Pharmacology

DOI

2019

Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

Songlin Liu, Dun Yuan, Yifeng Li, Qi Qi, Bingzhong Guo, Shun Yang, Jilin Zhou, Chaofu Lu, Tiange Chen, Chenxing Yang, Junyu Liu, Buyan Li, Yao Li, Weixi Jiang

Frontiers in Pharmacology

DOI

2019

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Changliang Shan, Zhaoliang Lu, Zhen Li, Hao Sheng, Jun Fan, Qi Qi, Shuangping Liu, Shuai Zhang

Cell Death and Disease

DOI

2019

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Shuai Zhang, Hao Sheng, Xiaoya Zhang, Qi Qi, Chi Bun Chan, Leilei Li, Changliang Shan, Keqiang Ye

Cell Death and Disease

DOI

2018

Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein

Lijuan Deng, Ming Qi, Qun-Long Peng, Min-Feng Chen, Qi Qi, Jiayan Zhang, Nan Yao, Maohua Huang, Xiaobo Li, Yin-Hui Peng, Jun-Shan Liu, Deng-Rui Fu, Jiaxu Chen, Wen‐Cai Ye, Dongmei Zhang

Cancer Cell International

DOI

精选作品

期刊论文

基于斑马鱼模型和网络药理学探讨积雪草酸对MASLD的作用及潜在机制

NONHSAT001931 ceRNA轴可能在高级别鳞状上皮内病变向宫颈癌进展中发挥调控作用

Dual inhibition of glycolysis and glutaminolysis by targeting FOXO3 for hepatocellular carcinoma treatment

GDPPH1 induces cell cycle arrest by downregulation of CDK4/Cyclin D1 via the m6A-METTL14-YTHDF2 axis, attenuating glioblastoma progression

Sulforaphane: An emerging star in neuroprotection and neurological disease prevention

Correction to: Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Correction: 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy

CK2α-mediated phosphorylation of DUB3 promotes YAP1 stability and oncogenic functions

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype

N-3, a novel synthetic derivative of bifendate, inhibits metastasis of triple-negative breast cancer via decreasing p38-regulated FOXC1 protein stability.

Chemotherapy-induced metastasis: molecular mechanisms and clinical therapies

Glucose-6-phosphate dehydrogenase: a therapeutic target for ovarian cancer

lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2.

ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy

TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold‐Sensing TRPM8 Channel

Oncogenic KRAS effector USP13 promotes metastasis in non-small cell lung cancer through deubiquitinating β-catenin

Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

Beauvericin suppresses the proliferation and pulmonary metastasis of osteosarcoma by selectively inhibiting TGFBR2 pathway

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

GPER-mediated stabilization of HIF-1α contributes to upregulated aerobic glycolysis in tamoxifen-resistant cells

Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

m6A modification: recent advances, anticancer targeted drug discovery and beyond

Novel TCF21 high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

Tumor perivascular cell-derived extracellular vesicles promote angiogenesis via the Gas6/Axl pathway

3′-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR

Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription

Octamer transcription factor-1 induces the Warburg effect via up-regulation of hexokinase 2 in non-small cell lung cancer

Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

Timosaponin AIII Induces G2/M Arrest and Apoptosis in Breast Cancer by Activating the ATM/Chk2 and p38 MAPK Signaling Pathways

Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment

Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

Involvement of E-cadherin/AMPK/mTOR axis in LKB1-induced sensitivity of non-small cell lung cancer to gambogic acid

Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis

Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation

Arenobufagin induces MCF-7 cell apoptosis by promoting JNK-mediated multisite phosphorylation of Yes-associated protein

书籍章节

Renin-Angiotensin System and Cancer: From Laboratory to Clinics

研究方向