魏湲颜｜复旦大学｜学者主页

2024

免疫学教学中“聚糖与免疫”相关内容的引入与探讨

魏湲颜，杨悦蓉，徐金强，江建海

《生命的化学》

2024

Deciphering the cell surface glyco-code: a promising perspective on unveiling the vulnerability of cancer stem cells

Yuanyan Wei, An Wei, Yi-Rong Li, Yue-ning Yang, Yu Si, Yi Li, Zhijun Fan, Jianhai Jiang

Cancer Biology and Medicine

DOI

2024

Protocol for sorting cancer stem cells using a combination of anti-CD133 antibody and lectin cyanovirin-N

Yuanyan Wei, Shuting Geng, Qihang Chen, Jiayue Chen, Zhijun Fan, Yi Li, Yu Si, Yue-ning Yang, Zi-Wei Liang, Jianhai Jiang

STAR Protocols

DOI

2023

生物化学教学中“聚糖与医学”相关内容的引入与探讨

魏湲颜，司雨，江建海

《生命的化学》

2023

The Interaction between Collagen 1 and High Mannose Type CD133 Up‐Regulates Glutamine Transporter SLC1A5 to Promote the Tumorigenesis of Glioblastoma Stem Cells

Yuanyan Wei, Shuting Geng, Yu Si, Yue-ning Yang, Qihang Chen, Sijing Huang, Xiao-Ning Chen, Wenlong Xu, Yin-Chao Liu, Jian-Hai Jiang

Advancement of science

DOI

2023

Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability.

Sijing Huang, Zhi Ji, Jinqiang Xu, Yue-ning Yang, Bingrui Wu, Qihang Chen, Shuting Geng, Yu Si, Jiayue Chen, Yuanyan Wei, Cong Wang, Zhilong Ai, Jian-Hai Jiang

Glycobiology

DOI

2023

Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction.

Yuanyan Wei, Qihang Chen, Jiayue Chen, Chen-Hao Zhou, Shuting Geng, Danfang Shi, Sijing Huang, Zhiwei Liang, Xiao-Ning Chen, Ning Ren, Jian-Hai Jiang

Cell Reports

DOI

2022

The Interaction between DNMT1 and High‐Mannose CD133 Maintains the Slow‐Cycling State and Tumorigenic Potential of Glioma Stem Cell

Yuanyan Wei, Qihang Chen, Si-Jing Huang, Yingchao Liu, Yinan Li, Yang Xing, Danfang Shi, Wenlong Xu, Weitao Liu, Zhi Ji, Bingrui Wu, Xiao-Ning Chen, Jian-Hai Jiang

Advancement of science

DOI

2021

N-糖基化在肿瘤细胞逃逸CD8+T细胞中的意义和机制

吉致，吴冰蕊，魏湲颜，江建海

《生命的化学》

DOI

2021

Siglecs介导肿瘤免疫逃逸的研究进展

陈启航，魏湲颜，江建海

《生命的化学》

DOI

2021

Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44

Weitao Liu, Zhi Ji, Bingrui Wu, Si-Chao Huang, Qihang Chen, Xiao-Ning Chen, Yuanyan Wei, Jian-Hai Jiang

FEBS Letters

DOI

2021

The binding of LDN193189 to CD133 C-terminus suppresses the tumorigenesis and immune escape of liver tumor-initiating cells.

Zi-Wei Liang, Bingrui Wu, Zhi Ji, Weitao Liu, Danfang Shi, Xiao-Ning Chen, Yuanyan Wei, Jian-Hai Jiang

Cancer Letters

DOI

2020

N‐acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1

Yinan Li, Yingchao Liu, Hongda Zhu, Xiao-Ning Chen, Mi Tian, Yuanyan Wei, Ye Gong, Jian-Hai Jiang

FEBS Letters

DOI

2019

O‐GlcNAc transferase activates stem‐like cell potential in hepatocarcinoma through O‐GlcNAcylation of eukaryotic initiation factor 4E

Benjin Cao, Meng Duan, Yang Xing, Chanjuan Liu, Fan Yang, Yinan Li, Tian-Xiao Yang, Yuanyan Wei, Q. Gao, Jian-Hai Jiang

Journal of Cellular and Molecular Medicine

DOI

2019

IL-17A Secreted from Lymphatic Endothelial Cells Promotes Tumorigenesis by Up-regulation of PD-L1 in Hepatoma Stem Cells.

Yuanyan Wei, Danfang Shi, Zi-Wei Liang, Yuming Liu, Yinan Li, Yang Xing, Weitao Liu, Zhilong Ai, Jian-Hui Zhuang, Xiao-Ning Chen, Q. Gao, Jian-Hai Jiang

Journal of Hepatology

DOI

2019

Complex N‐glycan promotes CD133 mono‐ubiquitination and secretion

Yinan Li, Danfang Shi, Fan Yang, Xiao-Ning Chen, Yang Xing, Zi-Wei Liang, Jian-Hui Zhuang, Weitao Liu, Ye Gong, Jian-Hai Jiang, Yuanyan Wei

FEBS Letters

DOI

2018

Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

Fan Yang, Yang Xing, Yinan Li, Xiao-Ning Chen, Jian-Hai Jiang, Zhilong Ai, Yuanyan Wei

Molecular and Cellular Biology

DOI

2017

β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells

Chunhong Cui, Xiao-Ning Chen, Ying Liu, Benjin Cao, Yang Xing, Chanjuan Liu, Fan Yang, Yinan Li, Tian-Xiao Yang, Ling-Yang Hua, Mi Tian, Yuanyan Wei, Ye Gong, Jian-Hai Jiang

Journal of Biological Chemistry

DOI

2016

ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation

Yang Xing, Yuqing Ge, Chanjuan Liu, Xiaobiao Zhang, Jian-Hai Jiang, Yuanyan Wei

OncoTarget

DOI

2016

The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration*

Chanjuan Liu, Yinan Li, Yang Xing, Benjin Cao, Fan Yang, Tian-Xiao Yang, Zhilong Ai, Yuanyan Wei, Jian-Hai Jiang

Journal of Biological Chemistry

DOI

2015

Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth

Ying Liu, Shi-Fang Ren, Liqi Xie, Chunhong Cui, Yang Xing, Chanjuan Liu, Benjin Cao, Fan Yang, Yinan Li, Xiao-Ning Chen, Yuanyan Wei, Hao-Jie Lu, Jian-Hai Jiang

OncoTarget

DOI

2013

Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

Yuanyan Wei, Yi-Zhou Jiang, Fei Zou, Yingchao Liu, Shan-Shan Wang, Nuo Xu, Wenlong Xu, Chunhong Cui, Yang Xing, Y. Liu, Benjin Cao, Chanjuan Liu, Guoqiang Wu, Hong Ao, Xiaobiao Zhang, Jian-Hai Jiang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2011

Use of CD133 in preparation of tumor marker and kit of CD133

Yi-Zhou Jiang, Jian-Hai Jiang, Shan Wang, Nuo Xu, Fei Zou, Yuanyan Wei

2010

Alpha2,3-Sialylation regulates the stability of stem cell marker CD133.

Feng-Biao Zhou, Chunhong Cui, Yuqing Ge, Hong Chen, Qiu-Meng Li, Zhiyuan Yang, Guoqiang Wu, Shuhui Sun, Kangli Chen, Jian-xin Gu, Jian-Hai Jiang, Yuanyan Wei

Journal of Biochemistry (Tokyo)

DOI

2010

Hepatitis B virus X protein blunts senescence‐like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage

Jiejie Xu, Xiao-jing Yun, Jian-Hai Jiang, Yuanyan Wei, Yi-hong Wu, Wei Zhang, Ye-Heng Liu, Wen-zhong Wang, Yu-Mei Wen, Jian-Xin Gu

Hepatology

DOI

2010

Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells.

Yuqing Ge, Feng-Biao Zhou, Hong Chen, Chunhong Cui, Dan Liu, Qiu-Meng Li, Zhiyuan Yang, Guoqiang Wu, Shuhui Sun, Jian-xin Gu, Yuanyan Wei, Jian-Hai Jiang

Biochemical and Biophysical Research Communications - BBRC

DOI

2010

Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.

Yuanyan Wei, Feng-Biao Zhou, Yuqing Ge, Hong Chen, Chunhong Cui, Qiu-Meng Li, Dan Liu, Zhiyuan Yang, Guoqiang Wu, Shuhui Sun, Jian-xin Gu, Jian-Hai Jiang

Biochemical and Biophysical Research Communications - BBRC

DOI

2010

Regulation of the beta1,4-Galactosyltransferase I promoter by E2F1.

Yuanyan Wei, Feng-Biao Zhou, Yuqing Ge, Hong Chen, Chunhong Cui, Dan Liu, Zhiyuan Yang, Guoqiang Wu, Jialin Shen, Jian-xin Gu, Jian-Hai Jiang

Journal of Biochemistry (Tokyo)

DOI

2010

Identification and characterization of the promoter of human ATF5 gene.

Yuanyan Wei, Yuqing Ge, Feng-Biao Zhou, Hong Chen, Chunhong Cui, Dan Liu, Zhiyuan Yang, Guoqiang Wu, Jian-xin Gu, Jian-Hai Jiang

Journal of Biochemistry (Tokyo)

DOI

2009

HSP70 protects BCL2L12 and BCL2L12A from N‐terminal ubiquitination‐mediated proteasomal degradation

Jun-wu Yang, Yi Hong, Wenzong Wang, Weibing Wu, Y. Chi, Hong-Liang Zong, Xiangfei Kong, Yuanyan Wei, Xiao-jing Yun, Chunming Cheng, Kangli Chen, Jian-xin Gu

FEBS Letters

DOI

2008

人转录激活因子ATF5的功能和调控的研究

魏湲颜

《复旦大学》

2008

Cdc34-mediated Degradation of ATF5 Is Blocked by Cisplatin*

Yuanyan Wei, Jian-Hai Jiang, Dan Liu, Jin Zhou, Xiao-Ning Chen, Si Zhang, Hong-Liang Zong, Xiao-jing Yun, Jian-xin Gu

Journal of Biological Chemistry

DOI

2008

Knockdown of BCL2L12 leads to cisplatin resistance in MDA-MB-231 breast cancer cells.

Yi Hong, Jun-wu Yang, Weibing Wu, Wenzong Wang, Xiangfei Kong, Yanlin Wang, Xiao-jing Yun, Hong-Liang Zong, Yuanyan Wei, Si Zhang, Jian-xin Gu

Biochimica et Biophysica Acta

DOI

2008

E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain.

Dan Liu, Yuanyan Wei, Feng-Biao Zhou, Yuqing Ge, Jiejie Xu, Hong Chen, Wei Zhang, Xiao-jing Yun, Jian-Hai Jiang

Archives of Biochemistry and Biophysics

DOI

2008

Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage.

Yuanyan Wei, Dan Liu, Yuqing Ge, Feng-Biao Zhou, Jiejie Xu, Hong Chen, Jian-xin Gu, Jian-Hai Jiang

Journal of Biochemistry (Tokyo)

DOI

2008

Identification of beta-1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell.

Yuanyan Wei, Dan Liu, Feng-Biao Zhou, Yuqing Ge, Jiejie Xu, Xiao-jing Yun, Jian-xin Gu, Jian-Hai Jiang

Journal of Hepatology

DOI

2008

Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis.

Yuanyan Wei, Dan Liu, Yuqing Ge, Feng-Biao Zhou, Jiejie Xu, Hong Chen, Xiao-jing Yun, Jian-xin Gu, Jian-Hai Jiang

Cancer Letters

DOI

2007

Functional Interaction of E1AF and Sp1 in Glioma Invasion

Jian-Hai Jiang, Yuanyan Wei, Jialin Shen, Dan Liu, Xiao-Ning Chen, Jin Zhou, Hong-Liang Zong, Xiao-jing Yun, Xiangfei Kong, Si Zhang, Yanzhong Yang, Jian-xin Gu

Molecular and Cellular Biology

DOI

2007

E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription.

Jian-Hai Jiang, Yuanyan Wei, Dan Liu, Jin Zhou, Jialin Shen, Xiao-Ning Chen, Si Zhang, Xiangfei Kong, Jian-xin Gu

Biochemical and Biophysical Research Communications - BBRC

DOI

2007

beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.

Jian-Hai Jiang, Jin Zhou, Yuanyan Wei, Jialin Shen, Dan Liu, Xiao-Ning Chen, Si Zhang, Xiangfei Kong, Xiao-jing Yun, Jian-xin Gu

Biochemical and Biophysical Research Communications - BBRC

DOI

2007

Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate β1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis

Jialin Shen, Jian-Hai Jiang, Yuanyan Wei, Lei Zhou, Dan Liu, Jin Zhou, Jian-xin Gu

Molecular and Cellular Biochemistry

DOI

2007

Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis.

Jin Zhou, Yuanyan Wei, Dan Liu, X. Ge, Feng-Biao Zhou, Xiao-jing Yun, Jian-Hai Jiang, Jian-xin Gu

Journal of Biochemistry (Tokyo)

DOI

2006

Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells.

Jian-Hai Jiang, Jialin Shen, Tao Wu, Yuanyan Wei, Xiao-Ning Chen, Hong-Liang Zong, Si Zhang, Maoyun Sun, Jianhui Xie, Xiangfei Kong, Yanzhong Yang, Ai-Guo Shen, Han-Zhou Wang, Jian-xin Gu

Glycobiology

DOI

2006

β1,4-Galactosyltransferase V Functions as a Positive Growth Regulator in Glioma*

Jian-Hai Jiang, Xiao-Ning Chen, Jialin Shen, Yuanyan Wei, Tao Wu, Yanzhong Yang, Han-Zhou Wang, Hong-Liang Zong, Jun-wu Yang, Si Zhang, Jianhui Xie, Xiangfei Kong, Wei-Cheng Liu, Jian-xin Gu

Journal of Biological Chemistry

DOI

2006

Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.

Maoyun Sun, Yuanyan Wei, Luyang Yao, Jianhui Xie, Xiao-Ning Chen, Han-Zhou Wang, Jian-Hai Jiang, Jian-xin Gu

Biochemical and Biophysical Research Communications - BBRC

DOI

2006

Down-regulation of the expression of β1,4-galactosyltransferase V promotes integrin β1 maturation

Xiao-Ning Chen, Jian-Hai Jiang, Jun-wu Yang, Chun Chen, Maoyun Sun, Yuanyan Wei, Xiaoying Guang, Jian-xin Gu

DOI

2006

ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.

Yuanyan Wei, Jian-Hai Jiang, Maoyun Sun, Xiao-Ning Chen, Han-Zhou Wang, Jian-xin Gu

Biochemical and Biophysical Research Communications - BBRC

DOI

精选作品

期刊论文

免疫学教学中“聚糖与免疫”相关内容的引入与探讨

Deciphering the cell surface glyco-code: a promising perspective on unveiling the vulnerability of cancer stem cells

Protocol for sorting cancer stem cells using a combination of anti-CD133 antibody and lectin cyanovirin-N

生物化学教学中“聚糖与医学”相关内容的引入与探讨

The Interaction between Collagen 1 and High Mannose Type CD133 Up‐Regulates Glutamine Transporter SLC1A5 to Promote the Tumorigenesis of Glioblastoma Stem Cells

Siglec15 promotes the migration of thyroid carcinoma cells by enhancing the EGFR protein stability.

Loss of α-1,2-mannosidase MAN1C1 promotes tumorigenesis of intrahepatic cholangiocarcinoma through enhancing CD133-FIP200 interaction.

The Interaction between DNMT1 and High‐Mannose CD133 Maintains the Slow‐Cycling State and Tumorigenic Potential of Glioma Stem Cell

N-糖基化在肿瘤细胞逃逸CD8+T细胞中的意义和机制

Siglecs介导肿瘤免疫逃逸的研究进展

Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44

The binding of LDN193189 to CD133 C-terminus suppresses the tumorigenesis and immune escape of liver tumor-initiating cells.

N‐acetylglucosaminyltransferase I promotes glioma cell proliferation and migration through increasing the stability of the glucose transporter GLUT1

O‐GlcNAc transferase activates stem‐like cell potential in hepatocarcinoma through O‐GlcNAcylation of eukaryotic initiation factor 4E

IL-17A Secreted from Lymphatic Endothelial Cells Promotes Tumorigenesis by Up-regulation of PD-L1 in Hepatoma Stem Cells.

Complex N‐glycan promotes CD133 mono‐ubiquitination and secretion

Monoubiquitination of Cancer Stem Cell Marker CD133 at Lysine 848 Regulates Its Secretion and Promotes Cell Migration

β1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells

ER stress inducer tunicamycin suppresses the self-renewal of glioma-initiating cell partly through inhibiting Sox2 translation

The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration*

Mutation of N-linked glycosylation at Asn548 in CD133 decreases its ability to promote hepatoma cell growth

Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells

Use of CD133 in preparation of tumor marker and kit of CD133

Alpha2,3-Sialylation regulates the stability of stem cell marker CD133.

Hepatitis B virus X protein blunts senescence‐like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage

Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells.

Beta1,4-galactosyltransferase V regulates self-renewal of glioma-initiating cell.

Regulation of the beta1,4-Galactosyltransferase I promoter by E2F1.

Identification and characterization of the promoter of human ATF5 gene.

HSP70 protects BCL2L12 and BCL2L12A from N‐terminal ubiquitination‐mediated proteasomal degradation

人转录激活因子ATF5的功能和调控的研究

Cdc34-mediated Degradation of ATF5 Is Blocked by Cisplatin*

Knockdown of BCL2L12 leads to cisplatin resistance in MDA-MB-231 breast cancer cells.

E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain.

Identification of E1AF as a target gene of E2F1-induced apoptosis in response to DNA damage.

Identification of beta-1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell.

Down-regulation of beta1,4GalT V at protein level contributes to arsenic trioxide-induced glioma cell apoptosis.

Functional Interaction of E1AF and Sp1 in Glioma Invasion

E1AF promotes breast cancer cell cycle progression via upregulation of Cyclin D3 transcription.

beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.

Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate β1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis

Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis.

Down-regulation of beta1,4-galactosyltransferase V is a critical part of etoposide-induced apoptotic process and could be mediated by decreasing Sp1 levels in human glioma cells.

β1,4-Galactosyltransferase V Functions as a Positive Growth Regulator in Glioma*

Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3.

Down-regulation of the expression of β1,4-galactosyltransferase V promotes integrin β1 maturation

ATF5 increases cisplatin-induced apoptosis through up-regulation of cyclin D3 transcription in HeLa cells.

会议论文

干细胞标志物CD133蛋白在肿瘤干细胞中的功能和机制

干细胞标志物CD133蛋白的糖链结构和功能

N-glycosylation inhibitor tunicamycin suppresses the self-renewal of glioma-initiating cell

N-糖链在肿瘤干细胞中的功能和调控

三氧化二砷通过下调β1，4半乳糖基转移酶V诱导胶质瘤细胞凋亡