陈薛钗｜北京工业大学｜学者主页

2026

Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation

Xuechai Chen, Chunsen Yuan, Zihan Li, Tianyuan Zhao, Yuanzhan Yang, Yulu Wang, Chenye Qiao, Zongjian Liu, Xiaoqiong Li

npj Microgravity

DOI

2025

一种帕金森病相关泛素样蛋白——Salsolinol合成酶的空间结构模拟和体外催化功能研究

张桂铭，张丽华，王雨露，陈薛钗

《中国生物工程杂志》

2025

甜菜碱神经保护作用的研究进展

赵天源，王菁，王雨露，袁春森，陈薛钗

《生物技术进展》

DOI

2025

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion

Wenting Zhang, Cuicui Ji, Xianghua Li, Tianlong He, Wei Jiang, Yukun Liu, Meiling Wu, Yunpeng Zhao, Xuechai Chen, Xiaoli Wang, Jian Li, Haolin Zhang, Juan Wang

Nature Communications

DOI

2025

The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson’s Disease

Yulu Wang, Tianyuan Zhao, Chunsen Yuan, Xuechai Chen

Biomolecules

DOI

2024

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Jianan Wang, Yuanyuan Ran, Zihan Li, Tianyuan Zhao, Fangfang Zhang, Juan Wang, Zongjian Liu, Xuechai Chen

Neural Regeneration Research

DOI

2024

Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health

Zihan Li, Jiarui Wu, Tianyuan Zhao, Yiyun Wei, Yajing Xu, Zongjian Liu, Xiaoqiong Li, Xuechai Chen

Frontiers in Cellular Neuroscience

DOI

2022

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

Fangfang Zhang, Yuanyuan Ran, Muhammad Tahir, Zihan Li, Jianan Wang, Xuechai Chen

Frontiers in Cellular Neuroscience

DOI

2022

Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol

Qianqian Xiong, Xiaotong Zheng, Jianan Wang, Zixuan Chen, Yulin Deng, Rugang Zhong, Juan Wang, Xuechai Chen

Journal of Integrative Neuroscience

DOI

2021

基于转录组测序技术揭示salsolinol的神经毒性作用

张芳芳，李梓晗，高怿宣，王雨桐，冯予鑫，王佳楠，陈薛钗

《生命科学仪器》

2021

Key Regulators of Autophagosome Closure

Wenyan Jiang, Xuechai Chen, Cuicui Ji, Wenting Zhang, Jianing Song, Jie Li, Juan Wang

Cells

DOI

2021

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Xuechai Chen, Jianan Wang, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang, Juan Wang

Cell & Bioscience

DOI

2021

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐ κ B Suppression and NLRP3 Inflammasome Inhibition

Yuanyuan Ran, Wei Su, Fuhai Gao, Zitong Ding, Shui-Qing Yang, Lin Ye, Xuechai Chen, Guiqin Tian, Jianing Xi, Zongjian Liu

Oxidative Medicine and Cellular Longevity

DOI

2020

Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion

Yuting Li, Xuechai Chen, Qianqian Xiong, Yong Chen, Hongyu Zhao, Muhammad Tahir, Jingdong Song, Bing Zhou, Juan Wang

Frontiers in Cell and Developmental Biology

DOI

2019

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death

Xuechai Chen, Chunyu Yu, Minjun Guo, Xiaotong Zheng, Sakhawat Ali, Hua Huang, Lihua Zhang, Shensen Wang, Yinghui Huang, Shuyan Qie, Juan Wang

ACS Chemical Neuroscience

DOI

2018

Isolation and Sequencing of Salsolinol Synthase, an Enzyme Catalyzing Salsolinol Biosynthesis

Xuechai Chen, Xiaotong Zheng, Sakhawat Ali, Minjun Guo, Rugang Zhong, Zixuan Chen, Yongqian Zhang, Hong Qing, Yulin Deng

ACS Chemical Neuroscience

DOI

2018

Changes in salsolinol production and salsolinol synthase activity in Parkinson’s disease model

Xiaotong Zheng, Xuechai Chen, Minjun Guo, Sakhawat Ali, Yinghui Huang, Feiyi Sun, Kefu Liu, Zixuan Chen, Yulin Deng, Rugang Zhong

Neuroscience Letters

DOI

2017

1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的神经生物学功能研究进展

郑晓彤，陈薛钗，陈姿喧，庆宏，邓玉林，钟儒刚，郭敏军

《生物医学工程学杂志》

2017

m 6 A RNA Modification Determines Cell Fate by Regulating mRNA Degradation

Minjun Guo, Xinhui Liu, Xiaotong Zheng, Yinghui Huang, Xuechai Chen

Cellular Reprogramming

DOI

2017

[Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline].

Xiaotong Zheng, Xuechai Chen, Zixuan Chen, Hong Qing, Yulin Deng, Rugang Zhong, Minjun Guo

PubMed

DOI

2015

Salsolinol合成酶的克隆和表达

冯程程，陈薛钗，刘可夫，曾凡，庆宏，邓玉林

《科技导报》

2013

TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity

Abida Arshad, Xuechai Chen, Zhenzhen Cong, Hong Qing, Yulin Deng

Acta Biochimica et Biophysica Sinica

DOI

2011

Enzymatic condensation of dopamine and acetaldehyde: a salsolinol synthase from rat brain

Xue-Chai Chen, A. Arshad, H. Qing, Rui Wang, Jian-Jun Lu, Yu-Lin Deng

Biologia

DOI

2011

Notice of RetractionCharacterization of Salsolinol Synthase from Rat Brain

Xue-Chai Chen, A. Arshad, Yi Chen, Shengping Dai, S. Xiao, Yu-Lin Deng

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2011

Notice of RetractionPreliminary Purification of Salsolinol Synthase from Rat Brain

Xue-Chai Chen, A. Arshad, Xiaoying Lin, Yi Chen, Jing Shen, Yong-Qian Zhang, Yu-Lin Deng

International Conferences on Biomedical and Bioinformatics Engineering

DOI

2010

Salsolinol合成酶的高效液相色谱-电化学活性检测方法研究

陈薛钗，王睿，毛健，丛珍珍，林汉斌，邓玉林

《化学通报(中英文)》

2009

[Determination of 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline, 5-hydroxytryptamine and 5-hydroxyindole acetic acid in the neonatal rat brains using high performance iquid chromatography-electrochemical detection].

Jian Mao, Yang Su, Yu-Jing Luan, Xue-Chai Chen, Yu-Lin Deng

Se pu = Chinese journal of chromatography

陈薛钗

精选作品

期刊论文

Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation

一种帕金森病相关泛素样蛋白——Salsolinol合成酶的空间结构模拟和体外催化功能研究

甜菜碱神经保护作用的研究进展

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion

The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson’s Disease

Salsolinol as an RNA m6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health

Regulation of N6-methyladenosine (m6A) RNA methylation in microglia-mediated inflammation and ischemic stroke

Sal synthase induced cytotoxicity of PC12 cells through production of the dopamine metabolites salsolinol and N-methyl-salsolinol

基于转录组测序技术揭示salsolinol的神经毒性作用

Key Regulators of Autophagosome Closure

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Curcumin Ameliorates White Matter Injury after Ischemic Stroke by Inhibiting Microglia/Macrophage Pyroptosis through NF‐ κ B Suppression and NLRP3 Inflammasome Inhibition

Casein Kinase 1 Family Member CK1δ/Hrr25 Is Required for Autophagosome Completion

Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death

Isolation and Sequencing of Salsolinol Synthase, an Enzyme Catalyzing Salsolinol Biosynthesis

Changes in salsolinol production and salsolinol synthase activity in Parkinson’s disease model

1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的神经生物学功能研究进展

m 6 A RNA Modification Determines Cell Fate by Regulating mRNA Degradation

[Research progress of neurobiological function of 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline].

Salsolinol合成酶的克隆和表达

TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity

Enzymatic condensation of dopamine and acetaldehyde: a salsolinol synthase from rat brain

Notice of RetractionCharacterization of Salsolinol Synthase from Rat Brain

Notice of RetractionPreliminary Purification of Salsolinol Synthase from Rat Brain

Salsolinol合成酶的高效液相色谱-电化学活性检测方法研究

[Determination of 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-beta-carboline, 5-hydroxytryptamine and 5-hydroxyindole acetic acid in the neonatal rat brains using high performance iquid chromatography-electrochemical detection].

会议论文

Salsolinol合成酶的高效液相色谱-电化学活性检测方法的建立及初步分离纯化

预印本

Genome-Wide m6A Methylation Profiling Reveals Epitranscriptomic Dysregulation in Peripheral Blood Mononuclear Cells from Parkinson's Disease Patients

The m6A RNA methylation exerts a neuroprotective function by regulating the expression of α-synuclein

研究方向