李丹｜重庆医科大学｜学者主页

2026

Parallel 4-1BB Signaling in Dual DLL3/CD56-Targeting CAR-T Cells Triggers Adaptive Proliferation and Functional Persistence to Eradicate Small Cell Lung Cancer.

Yan-Na Lei, Di-Yuan Qin, Yan He, Pei Shu, Benxia Zhang, Yue Chen, Ning Liu, Xia He, Yu-Gu Zhang, Meng-Yao Chang, Xiao-Yu Li, Fu-Chun Guo, Liang-Liang Bai, M.-C. Feng, Fujue Wang, Yu Gao, Bo Zhu, Zhong-Jun Li, Dan Li, Yong-Sheng Wang, Yuquan Wei

Cancer Research

DOI

2025

Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy

M.-C. Feng, Qizhi Ma, Benxia Zhang, Yue Chen, Yang Yang, Xia He, Yao Zeng, Meng Jing, Xue-Jin Ou, Yixian Liu, Qian Li, Wei-Ting Liao, Xiaoyu Li, Si-Rui Tan, Diyuan Qin, Dan Li, Qiu Li, Yong-Sheng Wang

Cell Death and Differentiation

DOI

2025

Development and validation of machine learning models based on molecular features for estimating the probability of multiple primary lung carcinoma versus intrapulmonary metastasis in patients presenting multiple non-small cell lung cancers

Ning Liu, Xue Li, Xu Luo, Bin Liu, Jie Tang, F. Xiao, Wei-Ya Wang, Yuan Tang, Pei Shu, Benxia Zhang, Yue Chen, Di-Yuan Qin, Qizhi Ma, Fu-Chun Guo, Xiao-Jun Tang, Daxing Zhu, J. Mei, Weizhi Chen, Dan Li, Lili Jiang, Yong-Sheng Wang

Translational Lung Cancer Research

DOI

2025

结节型间变型弥漫大B细胞淋巴瘤1例

赵敏，李丹

《临床与实验病理学杂志》

DOI

2024

骨肉瘤新辅助化疗后肿瘤坏死率规范化评估

魏清柱，钟琳，蒋璐岑，李丹，周辉，王琪，韩安家

《临床与实验病理学杂志》

2024

淋巴结滤泡辅助T细胞淋巴瘤-血管免疫母细胞型临床病理特征和预后因素分析

贺娟，王星宇，何鸿，王立鑫，谭艳梅，李源鑫，黄颖，余快，赵敏，谢涛，李丹

《重庆医科大学学报》

2024

BRD4/NF-κB信号通路介导的铁死亡参与三阴性乳腺癌化疗耐药的机制

张硕稳，李丹，贺静，杜志兴，裴永彬

《重庆医科大学学报》

2024

胃肠道间质瘤病理诊断研究进展

李丹

《中国城乡企业卫生》

2023

Optimized CAR-T therapy based on spatiotemporal changes and chemotactic mechanisms of MDSCs induced by hypofractionated radiotherapy.

Benxia Zhang, Min Hu, Qizhi Ma, Kai Li, Xue Li, Xia He, Pei Shu, Yue Chen, Ge Gao, Diyuan Qin, Fu-Chun Guo, Jian Zhao, Ning Liu, K. Zhou, M.-C. Feng, Wei-Ting Liao, Dan Li, Xin Wang, Yong-Sheng Wang

Molecular Therapy

DOI

2023

肝细胞癌微血管癌栓、门静脉癌栓形成与Ki-67表达水平相关性分析

李丹，马建兵，王佳，柯萍

《浙江临床医学》

2023

纵隔低级别纤维黏液样肉瘤1例临床病理特征并文献复习

李倩倩，王艳，李丹，管春鸾，杨军，郭睿

《临床与实验病理学杂志》

2022

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

Qizhi Ma, Xia He, Benxia Zhang, Fu-Chun Guo, X. Ou, Qi-yu Yang, Pei Shu, Yue Chen, Kai Li, Ge Gao, Ya-Juan Zhu, Diyuan Qin, Jie Tang, Xiaoyu Li, Meng Jing, Jian Zhao, Zeming Mo, Ning Liu, Yao Zeng, K. Zhou, M.-C. Feng, Wei-Ting Liao, Wanting Lei, Qiu Li, Dan Li, Yong-Sheng Wang

Signal Transduction and Targeted Therapy

DOI

2022

肾上腺皮质癌中CENPF基因的表达及对患者治疗和预后的影响

王莉，李丹，唐凯，黄育刚

《临床与实验病理学杂志》

2021

Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

Kai Li, Houhui Shi, Benxia Zhang, X. Ou, Qizhi Ma, Yue Chen, Pei Shu, Dan Li, Yong-Sheng Wang

Signal Transduction and Targeted Therapy

DOI

2021

CXCL13 expression in mouse 4T1 breast cancer microenvironment elicits antitumor immune response by regulating immune cell infiltration

Qizhi Ma, Yue Chen, Qing Qin, Fu-Chun Guo, Yong-Sheng Wang, Dan Li

Precision Clinical Medicine

DOI

2021

Preclinical Safety Evaluation of a Recombinant Plasmid Vector Encoding Mature Human Neutrophil Peptide-1 by Repeated Local Administrations in Nonhuman Primates

Dan Li, Fu-Chun Guo, Ke-quan Chen, Xunning Yang, Yong-Sheng Wang

Human Gene Therapy

DOI

2021

膝关节置换术标本取材和病理诊断规范化的探讨

魏清柱，赵彤，钟琳，刘江欢，蒋璐岑，李丹

《诊断病理学杂志》

2021

甲状腺微小乳头状癌冰冻切片免疫组化的应用价值的研究

汤显斌，姚莉，郝颖华，李丹，袁玲玲，刘平，王代忠，王铁延，王莉，李珍，周美霖，王新红，瞿莹莹

《诊断病理学杂志》

2021

前列腺尤文肉瘤/原始神经外胚层肿瘤1例并文献复习

汤显斌，李丹，姚莉，郝颖华，陈修文，王代忠，袁玲玲，刘平，王铁延

《诊断病理学杂志》

2021

肝细胞肝癌中CENPF的表达及临床意义

李丹，黄育刚，汤显斌

《临床与实验病理学杂志》

2021

乳腺癌组织GFRα1、RET及NCAM表达水平与淋巴结转移关系的研究

丰锦春，李宇翔，李丹，杨亮，赵倩，朱丽萍，吴涛

《实用肿瘤杂志》

DOI

2020

Progression of malignant pleural effusion during the early stage of gefitinib treatment in advanced EGFR-mutant lung adenocarcinoma involving complex driver gene mutations

Ning Liu, Min Yu, T. Yin, Yong Jiang, Xuelian Liao, Jie Tang, Yanying Li, Diyuan Qin, Dan Li, Yong-Sheng Wang

Signal Transduction and Targeted Therapy

DOI

2020

Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

Diyuan Qin, Dan Li, Benxia Zhang, Yue Chen, Xuelian Liao, Xiaoyu Li, Peter B. Alexander, Yong-Sheng Wang, Qi-Jing Li

Oncoimmunology

DOI

2020

Regulation of MHC class I-independent NK cell education by SLAM family receptors.

Sha-Sha Chen, Dan Li, Yuande Wang, Qiaozhen Li, Zhongjun Dong

Advances in Immunology

DOI

2020

Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome.

Xiaoyu Li, You-Ling Gong, Dan Li, L. Xiang, Yuhong Ou, Li Jiang, Pei Shu, Xiao-Ke Liu, Fu-Chun Guo, Diyuan Qin, Zeming Mo, Qing Qin, Xin Wang, Yong-Sheng Wang

International Journal of Radiation Oncology, Biology, Physics

DOI

2020

Novel NLRC4‐ALK and EML4‐ALK double fusion mutations in a lung adenocarcinoma patient: A case report

Xueqian Wu, Wei-Ya Wang, B. Zou, Yanying Li, Xiaojuan Yang, Ning Liu, Qizhi Ma, Xiaoxuan Zhang, Yong-Sheng Wang, Dan Li

Thoracic Cancer

DOI

2019

Multiphase contrast-enhanced computed tomography imaging features of salivary duct carcinoma: differentiation from other salivary gland malignancies

Wenli Wu, Chenglong Wang, Dan Li, Jin Luo, Junyong Ye, Shengsheng Xu

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology

DOI

2019

薄层液基细胞学联合DNA定量分析检测在肺癌中的诊断价值

汪少华，李丹，黄丛改，王洁琼，万宇，昝潇，杨波，杨志惠

《临床与实验病理学杂志》

DOI

2019

林奇综合征相关的子宫内膜癌1例报道

王芳，于倩倩，李丹，刘宗谕，范丽梅

《中国实验诊断学》

2019

人肺腺癌中癌相关成纤维细胞的分离培养与初步分析

孙世杰，田雷，李丹，刘先俊，卜友泉

《重庆医科大学学报》

2018

改良根治术后的乳腺癌免疫组化3种分子亚型的预后特性及年复发变化

张晴，王旭波，李丹，岳欣，李彩红

《包头医学院学报》

2017

胃癌家族史与胃癌患者临床病理特征及预后的关系

李丹，王德强，王宏宇，任琎，陈德玉，顾汉刚，陈文琪，李小琴

《临床肿瘤学杂志》

2017

乳腺纤维瘤病样化生性癌的临床病理分析

李晶，丁向东，李丹，梁小曼

《临床与实验病理学杂志》

2017

原发性输卵管癌早期腹膜后广泛转移1例

谢占玲，姚广，曲波，祝贺，李丹，刘爱民

《中国实验诊断学》

2016

乳腺癌子宫转移1例报道

李丹，姚嫱

《中国癌症防治杂志》

2015

NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients.

Xiaoyu Li, Fu-Chun Guo, Yong-Mei Liu, Hui-Jiao Chen, F. Wen, Bin-Bin Zou, Dan Li, Q. Qin, Xiao-Ke Liu, Yali Shen, Yong-Sheng Wang

Oncology Letters

DOI

2015

人白介素-7重组蛋白的原核表达、纯化及活性测定

Jian-Cai Tang, Feng Long, Dan Li, Yong-Sheng Wang

2015

自噬相关基因Beclin1在外阴鳞状细胞癌中的表达及其临床意义

黎博一，江山，李丹，叶秀峰，赵文思，罗弋，朱宇熹，张涛

《临床与实验病理学杂志》

2014

Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial–mesenchymal transition and ILK signaling pathway

Dongmei Xiong, Yulin Liou, Jing S. Shu, Dan Li, Luyu Zhang, Junxia Chen

Experimental and Molecular Pathology

DOI

2014

胸腹水细胞块切片结合免疫组化在病理诊断中的应用体会

李红华，刘平，李丹

《中外医学研究》

2013

Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation

Sisi He, Tao Yin, Dan Li, Xiang Gao, Y. Wan, Xue-Lei Ma, Tinghong Ye, Fu-Chun Guo, Jianhong Sun, Ziqiang Lin, Yong-Sheng Wang

Journal of Translational Medicine

DOI

2013

CyclinE在颌面部皮肤鳞状细胞癌中的表达及意义

徐亚娟，金志威，张艳秋，赵春，李丹，刘文书

《中国实验诊断学》

2012

Effect of metformin on the effects of TKI on human lung carcinoma cells harboring KRAS or EGFR-T790M mutation.

Yong-Sheng Wang, Yu Ma, Dan Li, Fu-Chun Guo

DOI

2012

Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis

Li-Qiang Wang, Jing Zhang, Lulu Cai, Jing Wen, Hua-Shan Shi, Dan Li, Fu-Chun Guo, Yong-Sheng Wang

DOI

2012

A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation

Hua-Shan Shi, Xiang Gao, Dan Li, Qiong-wen Zhang, Yong-Sheng Wang, Yu Zheng, L. Cai, Ren-Ming Zhong, Ao Rui, Zhi-Yong Li, Haorun Zheng, Xian-Cheng Chen, Li-Juan Chen

International Journal of Nanomedicine

DOI

2012

AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model

Qingfei Wu, Chang-Yang Gong, Shuntao Luo, Dong-Mei Zhang, Shuang Zhang, Hua-Shan Shi, Lian Lu, Heng-Xiu Yan, Sha-Sha He, Dan Li, Li Yang, Xia Zhao, Yu-Quan Wei

BMC Cancer

DOI

2012

虹膜黑色素细胞瘤1例

李丹，李弘，李秀昆

《中国实验诊断学》

2012

Survivin蛋白在舌鳞癌中的表达及意义

徐亚娟，金志威，张艳秋，赵春，李丹，刘文书

《中国实验诊断学》

2010

Suppression of ovarian cancer growth via systemic administration with liposome-encapsulated adenovirus-encoding endostatin

Lin Yang, Lan-Lan Wang, Xiao-Qing Su, Xian-Cheng Chen, Dan Li, Shuntao Luo, Hua-Shan Shi, Lijuan Chen, Yu Wang

Cancer Gene Therapy

DOI

2010

2型糖尿病患者肾活检病理分析

范哲，孙国文，李丹，刘树军

《中国实验诊断学》

2010

涎腺多形性低度恶性腺癌3例临床病理分析

李丹，常筱颖，杨向红，高霭峰

《临床与实验病理学杂志》

2009

Intratumoral Expression of Mature Human Neutrophil Peptide-1 Mediates Antitumor Immunity in Mice

Yong-Sheng Wang, Dan Li, Hua-Shan Shi, Yan-jun Wen, Li Yang, N. Xu, Xian-Cheng Chen, Xiang Chen, Ping Chen, Jiong Li, Hong-xin Deng, Chun-ting Wang, G. Xie, Shan Huang, Yong-qiu Mao, Li-juan Chen, Xia Zhao, Yu-Quan Wei

Clinical Cancer Research

DOI

2009

原发睾丸NK/T细胞淋巴瘤2例报告及文献复习

李丹，林晓，米粲

《重庆医科大学学报》

2008

Human α-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice

N. Xu, Yong-Sheng Wang, Wu-bin Pan, Bo Xiao, Yan-jun Wen, Xian-Cheng Chen, Li-juan Chen, Hong-xin Deng, Jia You, B. Kan, A. Fu, Dan Li, Xia Zhao, Yu-quan Wei

Molecular Cancer Therapeutics

DOI

2008

卵巢伴环状小管性索肿瘤4例临床病理分析

李丹，杨向红，高霭峰

《诊断病理学杂志》

2007

Immunity against Tumor Angiogenesis Induced by a Fusion Vaccine with Murine β-Defensin 2 and mFlk-1

Yong-Sheng Wang, Guo-qing Wang, Yan-jun Wen, Lian Wang, Xian-Cheng Chen, Ping-Qian Chen, B. Kan, Jiong Li, Canhua Huang, You Lu, Qin Zhou, N. Xu, Dan Li, L. Fan, T. Yi, Hong-bo Wu, Yu-quan Wei

Clinical Cancer Research

DOI

2006

细胞DNA倍体分析评估宫颈上皮内瘤变

孙小蓉，车东媛，涂洪章，李丹，汪键

《中华肿瘤杂志》

2006

柠檬酸盐和EDTA缓冲液对弥漫性大B细胞淋巴瘤Ki-67和bcl-2抗原修复的比较

李丹，李甘地，刘卫平，李俸媛，潘云

《临床与实验病理学杂志》

2005

B细胞特异性激活蛋白Pax-5在淋巴瘤组织中的表达

李丹，李甘地，刘卫平，李俸媛，张文燕，廖殿英

《中华病理学杂志》

2005

96例淋巴母细胞淋巴瘤临床病理分析

潘云，刘卫平，李金范，张文燕，李俸媛，陆晓茜，李丹，李甘地

《中华血液学杂志》

2005

51例原发性结内弥漫性大B细胞淋巴瘤的预后相关因素分析

李丹，李甘地，刘卫平，张文燕，李俸媛，廖殿英

《中华血液学杂志》

2004

原发性中枢神经系统淋巴瘤的组织病理学与免疫组化特征

王宏勤，毛伯镛，李丹，张尚福，徐缓，张跃康，范益民，李宝玉

《山西医科大学学报》

2004

原发性中枢神经系统淋巴瘤的组织病理和免疫表型研究

王宏勤，范益民，毛伯镛，李丹，张尚福

《中华神经外科杂志》

2003

原发性肺结外边缘区B细胞淋巴瘤九例临床病理分析

李丹，李甘地，杨文秀，刘卫平，张尚福，李俸媛，李雷

《中国肺癌杂志》

精选作品

期刊论文

Parallel 4-1BB Signaling in Dual DLL3/CD56-Targeting CAR-T Cells Triggers Adaptive Proliferation and Functional Persistence to Eradicate Small Cell Lung Cancer.

Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy

Development and validation of machine learning models based on molecular features for estimating the probability of multiple primary lung carcinoma versus intrapulmonary metastasis in patients presenting multiple non-small cell lung cancers

结节型间变型弥漫大B细胞淋巴瘤1例

骨肉瘤新辅助化疗后肿瘤坏死率规范化评估

淋巴结滤泡辅助T细胞淋巴瘤-血管免疫母细胞型临床病理特征和预后因素分析

BRD4/NF-κB信号通路介导的铁死亡参与三阴性乳腺癌化疗耐药的机制

胃肠道间质瘤病理诊断研究进展

Optimized CAR-T therapy based on spatiotemporal changes and chemotactic mechanisms of MDSCs induced by hypofractionated radiotherapy.

肝细胞癌微血管癌栓、门静脉癌栓形成与Ki-67表达水平相关性分析

纵隔低级别纤维黏液样肉瘤1例临床病理特征并文献复习

A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis

肾上腺皮质癌中CENPF基因的表达及对患者治疗和预后的影响

Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer

CXCL13 expression in mouse 4T1 breast cancer microenvironment elicits antitumor immune response by regulating immune cell infiltration

Preclinical Safety Evaluation of a Recombinant Plasmid Vector Encoding Mature Human Neutrophil Peptide-1 by Repeated Local Administrations in Nonhuman Primates

膝关节置换术标本取材和病理诊断规范化的探讨

甲状腺微小乳头状癌冰冻切片免疫组化的应用价值的研究

前列腺尤文肉瘤/原始神经外胚层肿瘤1例并文献复习

肝细胞肝癌中CENPF的表达及临床意义

乳腺癌组织GFRα1、RET及NCAM表达水平与淋巴结转移关系的研究

Progression of malignant pleural effusion during the early stage of gefitinib treatment in advanced EGFR-mutant lung adenocarcinoma involving complex driver gene mutations

Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models

Regulation of MHC class I-independent NK cell education by SLAM family receptors.

Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome.

Novel NLRC4‐ALK and EML4‐ALK double fusion mutations in a lung adenocarcinoma patient: A case report

Multiphase contrast-enhanced computed tomography imaging features of salivary duct carcinoma: differentiation from other salivary gland malignancies

薄层液基细胞学联合DNA定量分析检测在肺癌中的诊断价值

林奇综合征相关的子宫内膜癌1例报道

人肺腺癌中癌相关成纤维细胞的分离培养与初步分析

改良根治术后的乳腺癌免疫组化3种分子亚型的预后特性及年复发变化

胃癌家族史与胃癌患者临床病理特征及预后的关系

乳腺纤维瘤病样化生性癌的临床病理分析

原发性输卵管癌早期腹膜后广泛转移1例

乳腺癌子宫转移1例报道

NLRC5 expression in tumors and its role as a negative prognostic indicator in stage III non-small-cell lung cancer patients.

人白介素-7重组蛋白的原核表达、纯化及活性测定

自噬相关基因Beclin1在外阴鳞状细胞癌中的表达及其临床意义

Down-regulating ribonuclease inhibitor enhances metastasis of bladder cancer cells through regulating epithelial–mesenchymal transition and ILK signaling pathway

胸腹水细胞块切片结合免疫组化在病理诊断中的应用体会

Enhanced interaction between natural killer cells and lung cancer cells: involvement in gefitinib-mediated immunoregulation

CyclinE在颌面部皮肤鳞状细胞癌中的表达及意义

Effect of metformin on the effects of TKI on human lung carcinoma cells harboring KRAS or EGFR-T790M mutation.

Liposomal curcumin inhibits Lewis lung cancer growth primarily through inhibition of angiogenesis

A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation

AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model

虹膜黑色素细胞瘤1例

Survivin蛋白在舌鳞癌中的表达及意义

Suppression of ovarian cancer growth via systemic administration with liposome-encapsulated adenovirus-encoding endostatin

2型糖尿病患者肾活检病理分析

涎腺多形性低度恶性腺癌3例临床病理分析

Intratumoral Expression of Mature Human Neutrophil Peptide-1 Mediates Antitumor Immunity in Mice

原发睾丸NK/T细胞淋巴瘤2例报告及文献复习

Human α-defensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice

卵巢伴环状小管性索肿瘤4例临床病理分析

Immunity against Tumor Angiogenesis Induced by a Fusion Vaccine with Murine β-Defensin 2 and mFlk-1

细胞DNA倍体分析评估宫颈上皮内瘤变

柠檬酸盐和EDTA缓冲液对弥漫性大B细胞淋巴瘤Ki-67和bcl-2抗原修复的比较

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