芦银华｜上海师范大学｜学者主页

2026

Evolution-guided high yield production of potent Gαq/11-signalling inhibitors FR900359 and YM-254890

Yiwen Zhou, Xinyi Zhao, Xingyu Zhao, Fei Zhang, Yunchuan Jia, Shuang Xia, Jianming Zhang, Yinhua Lü, Lei Li

Metabolic Engineering

DOI

2026

Multifaceted metabolic engineering of Streptomyces hygroscopicus for milbemycins overproduction

Jiafeng Xu, Guosong Zheng, Bin Ni, Jiajie Zhang, Delin You, Shaoxin Chen, Wenfang Wang, Yinhua Lü

Metabolic Engineering

DOI

2026

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Runze Sun, Ruixiang You, Yiwen Zhou, Huiyan He, Wen-Fang Wang, X. Qu, Yinhua Lu, Lei Li

Advancement of science

DOI

2025

Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa

Wenfang Wang, Huiyan He, Hewei Liu, Yuan Gao, Fujun Dang, Xiujuan Zhao, Shaoxin Chen, Lei Li, Yinhua Lü

Science China Life Sciences

DOI

2025

Stepwise engineering of Clostridium ljungdahlii for efficient ethanol production from single-carbon gases

Fengjuan Yang, Wanqi Li, Wei Ye, Peng Hu, Yinhua Lü, Weihong Jiang, Yang Gu

Green Carbon

DOI

2025

Enhancement of Spinosyn Production by Integrating a Static and Dynamic CRISPRi-Mediated Metabolic Switch in Saccharopolyspora spinosa

Wenfang Wang, Hewei Liu, Zhen Yang, Liyang Wang, W Li, Huiyan He, Shaoxin Chen, Min‐Juan Xu, Yinhua Lü

Journal of Agricultural and Food Chemistry

DOI

2025

Development and Application of an ACQUIRE Method for Direct Cloning of Superlarge Biosynthetic Gene Cluster

Wei J. Wang, Nan Ma, Tianwen Xu, Yi‐Lin Wu, Guosong Zheng, Li-Sha Zou, Xian-Lin Niu, Jin Yang, Guoping Zhao, Yinhua Lü, Hua Yuan

ACS Synthetic Biology

DOI

2025

Involvement of two-component system CseB-C in differential regulation of rapamycin and elaiophylin biosynthesis in Streptomyces rapamycinicus

Yawei Zhao, Shangping Jin, Pan Wang, Yuan Wang, Na Liu, Aimei Liao, Zhe Sun, Yinhua Lü, Hailong Tian

Food Bioscience

DOI

2025

Scalable secondary metabolite production in Streptomyces using a plug-and-play system

Bowen Yang, Zilong Li, Lixin Zhang, Shiwen Qiu, Xueting Liu, Zonglin Liang, Hao Yan, Yanyan Zhang, Lihong Liu, Bin Xia, Lianqun Bao, De‐Feng Li, Shanshan Zhou, Christophe Corre, Chengyu Zhang, Yinhua Lü, Gao‐Yi Tan, Xuekui Xia, Shanshan Li, Lixin Zhang, Weishan Wang

Nature Biotechnology

DOI

2025

Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast

Qin Wang, Ye Li, Shunhan Zhang, Wei Yuan, Zeqian Du, Ting Shi, Zhao Chang, Xingye Zhai, Yinhua Lü, Meng Wang, Juan Guo, Jian‐Jiang Zhong, Han Xiao

Cell Discovery

DOI

2025

iCASRED, a scarless DNA editing tool in E. coli for high-efficiency engineering of natural product biosynthetic gene clusters

Guosong Zheng, Jiafeng Xu, Hewei Liu, Hui‐Min Hua, Andrei Antonovich Zimin, Wenfang Wang, Yinhua Lü

Synthetic and Systems Biotechnology

DOI

2024

A tunable and reversible thermo-inducible bio-switch for streptomycetes

Lanxin Lv, Shuo Liu, Yudie Fu, Yuxin Zhang, Meiyan Wang, Jiahe Sun, Yi Wang, Yinhua Lü, Guoqing Niu

Nucleic Acids Research

DOI

2024

Low-Toxicity and High-Efficiency Streptomyces Genome Editing Tool Based on the Miniature Type V–F CRISPR/Cas Nuclease AsCas12f1

Hui‐Min Hua, Jiafeng Xu, Xue-Shuang Huang, Andrei Antonovich Zimin, Wenfang Wang, Yinhua Lü

Journal of Agricultural and Food Chemistry

DOI

2024

Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing

Shuliu Wang, Xiaoqian Zeng, Yue Jiang, Weishan Wang, Linquan Bai, Yinhua Lü, Lixin Zhang, Gao‐Yi Tan

Natural Product Reports

DOI

2023

Development of a CRISPR/Cas9D10A Nickase (nCas9)-Mediated Genome Editing Tool in Streptomyces

Jiaxiang Ma, Wenyan He, Hui‐Min Hua, Qian Zhu, Guosong Zheng, Andrei Antonovich Zimin, Wenfang Wang, Yinhua Lü

ACS Synthetic Biology

DOI

2023

Elucidation of the ferrichrome siderophore biosynthetic pathway in albomycin-producing Streptomyces sp. ATCC 700974

Zhilei Li, Lang He, Xia Wang, Qingwen Huo, Guosong Zheng, Dekun Kong, Yinhua Lü, Haiyang Xia, Guoqing Niu

Journal of Biological Chemistry

DOI

2023

An overview on the two-component systems of Streptomyces coelicolor

Shangping Jin, Ming Hui, Yinhua Lü, Yawei Zhao

World Journal of Microbiology and Biotechnology

DOI

2022

Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus

Wenyan He, Wenfang Wang, Jiaxiang Ma, Guosong Zheng, Andrei Antonovich Zimin, Weihong Jiang, Jinzhong Tian, Yinhua Lü

Applied Microbiology and Biotechnology

DOI

2021

天蓝色链霉菌中抗生素合成相关双组分调控系统AfsQ1/Q2上游信号传导机制的研究

陈允亮，杨云鹏，李国权，毛雪芳，贾卫东，施爱平，芦银华

《生物化学与生物物理进展》

DOI

2021

雷帕链霉菌次级代谢产物及其生物合成的研究进展

和文燕，芦银华

《中国抗生素杂志》

DOI

2021

Identification of the cognate response regulator of the orphan histidine kinase OhkA involved in both secondary metabolism and morphological differentiation in Streptomyces coelicolor

Guosong Zheng, Panpan Liu, Wenyan He, Hengnuo Tao, Zhen Yang, Chuanwen Sun, Wenfang Wang, Yinhua Lü, Weihong Jiang

Applied Microbiology and Biotechnology

DOI

2021

Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions in Streptomyces

Yanping Zhu, Peipei Zhang, Ting Lu, Xinyuan Wang, Aiying Li, Yinhua Lü, Meifeng Tao, Xiuhua Pang

Environmental Microbiology

DOI

2021

Recent Advances in Strategies for the Cloning of Natural Product Biosynthetic Gene Clusters

Wenfang Wang, Guosong Zheng, Yinhua Lü

Frontiers in Bioengineering and Biotechnology

DOI

2020

Editorial: Regulation of Antibiotic Production in Actinomycetes

Yvonne Mast, Evi Stegmann, Yinhua Lü

Frontiers in Microbiology

DOI

2020

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

Jinzhong Tian, Gaohua Yang, Yang Gu, Xin-Qiang Sun, Yinhua Lü, Weihong Jiang

Nucleic Acids Research

DOI

2020

Impact on Multiple Antibiotic Pathways Reveals MtrA as a Master Regulator of Antibiotic Production inStreptomycesspp. and Potentially in Other Actinobacteria

Yanping Zhu, Peipei Zhang, Jing Zhang, Jiao Wang, Yinhua Lü, Xiuhua Pang

Applied and Environmental Microbiology

DOI

2020

Challenges and Advances in Genome Editing Technologies in Streptomyces

Yawei Zhao, Guoquan Li, Yunliang Chen, Yinhua Lü

Biomolecules

DOI

2020

The orphan histidine kinase PdtaS-p regulates both morphological differentiation and antibiotic biosynthesis together with the orphan response regulator PdtaR-p in Streptomyces

Lei Li, Yawei Zhao, Jingjing Ma, Hengnuo Tao, Guosong Zheng, Jun Chen, Weihong Jiang, Yinhua Lü

Microbiological Research

DOI

2019

雷帕霉素生物合成及其分子调控的研究进展

田进忠，姜卫红，芦银华

《中国抗生素杂志》

DOI

2019

碱基编辑器的开发及其在细菌基因组编辑中的应用

赵亚伟，姜卫红，邓子新，汪志军，芦银华

《微生物学通报》

DOI

2019

Multiplex genome editing using a dCas9-cytidine deaminase fusion in Streptomyces

Yawei Zhao, Jinzhong Tian, Guosong Zheng, Jun Chen, Chuanwen Sun, Zhongyi Yang, Andrei Antonovich Zimin, Weihong Jiang, Zixin Deng, Zhijun Wang, Yinhua Lü

Science China Life Sciences

DOI

2019

Overexpression of the diguanylate cyclase CdgD blocks developmental transitions and antibiotic biosynthesis in Streptomyces coelicolor

Xiaocao Liu, Guosong Zheng, Gang Wang, Weihong Jiang, Lei Li, Yinhua Lü

Science China Life Sciences

DOI

2019

Recent Advances in Synthetic Biology Approaches to Optimize Production of Bioactive Natural Products in Actinobacteria

Lei Li, Xiaocao Liu, Weihong Jiang, Yinhua Lü

Frontiers in Microbiology

DOI

2019

Synthetic biology approaches for chromosomal integration of genes and pathways in industrial microbial systems

Lei Li, Xiaocao Liu, Keke Wei, Yinhua Lü, Weihong Jiang

Biotechnology Advances

DOI

2019

The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes inStreptomyces coelicolor

Yanping Zhu, Peipei Zhang, Jing Zhang, Wenhao Xu, Xinyuan Wang, Lili Wu, Duohong Sheng, Wei Ma, Guangxiang Cao, Xiu‐Lan Chen, Yinhua Lü, Yu‐Zhong Zhang, Xiuhua Pang

Molecular Microbiology

DOI

2018

aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular recombinases in actinomycetes

Lei Li, Keke Wei, Xiaocao Liu, Yuanjie Wu, Guosong Zheng, Shaoxin Chen, Weihong Jiang, Yinhua Lü

Metabolic Engineering

DOI

2018

MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus

Keke Wei, Yuanjie Wu, Lei Li, Weihong Jiang, Jin‐Feng Hu, Yinhua Lü, Shaoxin Chen

Applied Microbiology and Biotechnology

DOI

2018

CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces

Lei Li, Keke Wei, Guosong Zheng, Xiaocao Liu, Shaoxin Chen, Weihong Jiang, Yinhua Lü

Applied and Environmental Microbiology

DOI

2018

CRISPR/dCas9‐Mediated Multiplex Gene Repression in Streptomyces

Yawei Zhao, Lei Li, Guosong Zheng, Weihong Jiang, Zixin Deng, Zhijun Wang, Yinhua Lü

Biotechnology Journal

DOI

2018

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Zeng‐Fei Pei, Minjie Yang, Lei Li, Xiao‐Hong Jian, Yue Yin, Dehai Li, Hai‐Xue Pan, Yinhua Lü, Weihong Jiang, Gong‐Li Tang

Organic & Biomolecular Chemistry

DOI

2017

细菌双组分系统应答调控蛋白调控策略的多样性

李雷，卫科科，姜卫红，芦银华

《中国科学:生命科学》

2017

Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins (RED) production

Panpan Liu, Hong Mei Zhu, Guosong Zheng, Weihong Jiang, Yinhua Lü

Science China Life Sciences

DOI

2015

合成生物学使能技术的研究进展

李雷，姜卫红，覃重军，薛小莉，芦银华

《中国科学:生命科学》

2013

DNA组装新方法的研究进展

李雷，芦银华，姜卫红

《生物工程学报》

2013

链霉菌次级代谢调控相关的双组分系统研究进展

芦银华，姜卫红

《微生物学通报》

2011

细菌信号传导调控元件的合成生物学研究进展

芦银华，姜卫红

《生物产业技术》

精选作品

期刊论文

Evolution-guided high yield production of potent Gαq/11-signalling inhibitors FR900359 and YM-254890

Multifaceted metabolic engineering of Streptomyces hygroscopicus for milbemycins overproduction

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria

Developing a robust genome editing tool based on an endogenous type I-B CRISPR-Cas system in Saccharopolyspora spinosa

Stepwise engineering of Clostridium ljungdahlii for efficient ethanol production from single-carbon gases

Enhancement of Spinosyn Production by Integrating a Static and Dynamic CRISPRi-Mediated Metabolic Switch in Saccharopolyspora spinosa

Development and Application of an ACQUIRE Method for Direct Cloning of Superlarge Biosynthetic Gene Cluster

Involvement of two-component system CseB-C in differential regulation of rapamycin and elaiophylin biosynthesis in Streptomyces rapamycinicus

Scalable secondary metabolite production in Streptomyces using a plug-and-play system

Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast

iCASRED, a scarless DNA editing tool in E. coli for high-efficiency engineering of natural product biosynthetic gene clusters

A tunable and reversible thermo-inducible bio-switch for streptomycetes

Low-Toxicity and High-Efficiency Streptomyces Genome Editing Tool Based on the Miniature Type V–F CRISPR/Cas Nuclease AsCas12f1

Unleashing the potential: type I CRISPR-Cas systems in actinomycetes for genome editing

Development of a CRISPR/Cas9D10A Nickase (nCas9)-Mediated Genome Editing Tool in Streptomyces

Elucidation of the ferrichrome siderophore biosynthetic pathway in albomycin-producing Streptomyces sp. ATCC 700974

An overview on the two-component systems of Streptomyces coelicolor

Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus

天蓝色链霉菌中抗生素合成相关双组分调控系统AfsQ1/Q2上游信号传导机制的研究

雷帕链霉菌次级代谢产物及其生物合成的研究进展

Identification of the cognate response regulator of the orphan histidine kinase OhkA involved in both secondary metabolism and morphological differentiation in Streptomyces coelicolor

Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions in Streptomyces

Recent Advances in Strategies for the Cloning of Natural Product Biosynthetic Gene Clusters

Editorial: Regulation of Antibiotic Production in Actinomycetes

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

Impact on Multiple Antibiotic Pathways Reveals MtrA as a Master Regulator of Antibiotic Production inStreptomycesspp. and Potentially in Other Actinobacteria

Challenges and Advances in Genome Editing Technologies in Streptomyces

The orphan histidine kinase PdtaS-p regulates both morphological differentiation and antibiotic biosynthesis together with the orphan response regulator PdtaR-p in Streptomyces

雷帕霉素生物合成及其分子调控的研究进展

碱基编辑器的开发及其在细菌基因组编辑中的应用

Multiplex genome editing using a dCas9-cytidine deaminase fusion in Streptomyces

Overexpression of the diguanylate cyclase CdgD blocks developmental transitions and antibiotic biosynthesis in Streptomyces coelicolor

Recent Advances in Synthetic Biology Approaches to Optimize Production of Bioactive Natural Products in Actinobacteria

Synthetic biology approaches for chromosomal integration of genes and pathways in industrial microbial systems

The developmental regulator MtrA binds GlnR boxes and represses nitrogen metabolism genes inStreptomyces coelicolor

aMSGE: advanced multiplex site-specific genome engineering with orthogonal modular recombinases in actinomycetes

MilR2, a novel TetR family regulator involved in 5-oxomilbemycin A3/A4 biosynthesis in Streptomyces hygroscopicus

CRISPR-Cpf1-Assisted Multiplex Genome Editing and Transcriptional Repression in Streptomyces

CRISPR/dCas9‐Mediated Multiplex Gene Repression in Streptomyces

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

细菌双组分系统应答调控蛋白调控策略的多样性

Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins (RED) production

合成生物学使能技术的研究进展

DNA组装新方法的研究进展

链霉菌次级代谢调控相关的双组分系统研究进展

细菌信号传导调控元件的合成生物学研究进展

会议论文

天蓝色链霉菌中参与抗生素合成及形态分化的孤立组氨酸激酶uHK01的鉴定及功能研究

天蓝色链霉菌A3(2)双组分调控系统的初步研究

天蓝色链霉菌双组分调控系统JyA1／A2缺失株的构建及其功能的初步研究

除虫链霉菌中阿弗菌素生物合成调控因子Avel的研究

研究方向