夏凌云｜湖北医药学院｜学者主页

2026

miR–185–5p通过IGFBP2调节口腔鳞状细胞癌细胞的增殖、凋亡

甘志恒，余子敬，毛敏，施俊，蒙建超，夏凌云

《蚌埠医科大学学报》

DOI

2026

Efficacy and safety of diode laser in pulpotomy: a systematic review and meta-analysis

Zi-Qi Cao, Nu-Nuo Pan, Fei-Fei Jia, Xiao-Mei Han, Ting Wei, Chao Zhang, Lingyun Xia, Min Mao

BMC Oral Health

DOI

2026

Vascular SMC-like CAF-derived THBS1 drives tumor-associated neutrophil recruitment to orchestrate an immunosuppressive microenvironment in gastric cancer

Dandan Li, Zeng Chao Zhou, Yanyan Chen, Pan Huang, Lin Yuan, Qi Wang, Xiangang Zhang, Lantian Zhai, Xinqi Li, Lingyun Xia, Weidong Leng, Shanshan Qin

Cell Death and Disease

DOI

2025

光学相干断层成像技术在口腔疾病诊断中的研究进展

刘娱溶，夏凌云

《湖北医药学院学报》

DOI

2025

EHBMT, a method for visualizing tumor evolution, identifies a surge in gastric cancer with hybrid epithelial–mesenchymal phenotypes due to an inflammatory microenvironment

Dandan Li, Zhou Zeng, Yuanjian Hui, Hedong Yu, Tao Ren, Lantian Zhai, Xinqi Li, Lin Yuan, Lingyun Xia, Wei‐Dong Leng, Shanshan Qin

Experimental & Molecular Medicine

DOI

2025

Hypermethylation-mediated HNF4A silencing by Helicobacter pylori infection drives gastric cancer by disrupting epithelial cell polarity and activating EMT signaling

Dandan Li, Zhou Zeng, Xinqi Li, Qiwei Guo, Lin Yuan, Xiangang Zhang, Lantian Zhai, Lingyun Xia, Weidong Leng, Shanshan Qin

Cell Death and Disease

DOI

2024

口腔颌面部肿瘤术后吞咽障碍的评估和康复管理专家共识

李小莹，孙沫逸，郭伟，廖贵清，唐瞻贵，李龙江，冉伟，任国欣，孙志军，孟箭，刘绍严，尚伟，张杰，何悦，李春洁，杨凯，龚忠诚，李吉辰，席庆，李刚，韩冰，陈彦平，常群安，吴亚东，麦华明，章杰，冷卫东，夏凌云，吴炜，杨向明，张春谊，杨帆，王艳平，曹田田

《实用口腔医学杂志》

2024

Cytotoxicity and Bone Biocompatibility of the C‐Root SP Experimental Root Canal Sealer

Xiliang Yang, Lingyun Xia, Yongji Chen, Lei Jiang, Tian‐Xia Zheng, Yuhong Bai

Australian Endodontic Journal

DOI

2024

Receptor accessory protein 6, a novel ferroptosis suppressor, drives oral squamous cell carcinoma by maintaining endoplasmic reticulum hemostasis

Lingyun Xia, Hongbing Wang, G.M. Du, Xiaobo Cheng, Rui Zhang, Hedong Yu, Mumo Cheng, Yongji Chen, Shanshan Qin, Weidong Leng

International Journal of Biological Macromolecules

DOI

2024

Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration

Yao Zhao, Yun-Fan Cai, Wenkai Wang, Yongkang Bai, Mingyi Liu, Yan Wang, Wen Niu, Zhixiao Luo, Lingyun Xia, Juanfang Zhu, Fei Zhao, Franklin R. Tay, Li‐na Niu

Bioactive Materials

DOI

2024

lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1

Shanshan Qin, Yue Liu, Xiangang Zhang, Pan Huang, Lingyun Xia, Wei‐Dong Leng, Dandan Li

Journal of Experimental & Clinical Cancer Research

DOI

2024

Multifunctional polyurethane materials in regenerative medicine and tissue engineering

Gao‐peng Dang, Jun‐ting Gu, Jinghan Song, Zhi-ting Li, Jiaxin Hao, Yuzhu Wang, Chenyu Wang, Tao Ye, Fei Zhao, Yufeng Zhang, Franklin R. Tay, Li‐na Niu, Lingyun Xia

Cell Reports Physical Science

DOI

2024

A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression

Shanshan Qin, Qiwei Guo, Yue Liu, Xiangang Zhang, Pan Huang, Hedong Yu, Lingyun Xia, Weidong Leng, Dandan Li

Cell Death and Disease

DOI

2024

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

Shuang-Ying Wang, Yi Cai, Xiao Hu, Fei Li, Xin-Hang Qian, Lingyun Xia, Bo Gao, Lan Wu, Wen‐Zhong Xie, Jia‐Min Gu, Tong Deng, Cong Zhu, Hai-Chang Jia, Wan-Qi Peng, Jiao Huang, Cheng Fang, Xian‐Tao Zeng

Military Medical Research

DOI

2024

Association between periodontitis and dental caries: a systematic review and meta-analysis

Yixin Li, Yonggang Xiang, Haixia Ren, Chao Zhang, Ziqiu Hu, Wei‐Dong Leng, Lingyun Xia

Clinical Oral Investigations

DOI

2024

A new high-throughput screening methodology for the discovery of cancer-testis antigen using multi-omics data

Dandan Li, Lingyun Xia, Xiangang Zhang, Yue Liu, Zidi Wang, Qiwei Guo, Pan Huang, Weidong Leng, Shanshan Qin

Computer Methods and Programs in Biomedicine

DOI

2024

Cancer-associated fibroblasts promote gastric cancer cell proliferation by paracrine FGF2-driven ribosome biogenesis

Dandan Li, Pan Huang, Lingyun Xia, Weidong Leng, Shanshan Qin

International Immunopharmacology

DOI

2023

miR-124-3p.2通过CMTM6调控口腔鳞状细胞癌细胞凋亡、铁死亡的机制研究

杜姗姗，叶双，解龙川，夏凌云

《河北医科大学学报》

2023

牙隐裂综合征研究现状的文献计量学分析

李艳琴，桂婷，陈永吉，石婷，夏凌云

《医学新知》

2023

Bacterial diversity in primary infected root canals of a Chinese cohort: analysis of 16 S rDNA sequencing

Ziqiu Hu, Yonggang Xiang, Yanhong Wei, Xinsheng Gu, Weidong Leng, Lingyun Xia

BMC Oral Health

DOI

2023

Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling

Lingyun Xia, Tianshu Zhang, Juncheng Yao, Kaitian Lu, Ziqiu Hu, Xinsheng Gu, Yongji Chen, Shanshan Qin, Wei‐Dong Leng

iScience

DOI

2023

Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin

Cell & Bioscience

DOI

2023

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin

Cell Proliferation

DOI

2023

Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin

Cell Death Discovery

DOI

2022

Genome-wide association studies identify miRNA-194 as a prognostic biomarker for gastrointestinal cancer by targeting ATP6V1F, PPP1R14B, BTF3L4 and SLC7A5

Pan Huang, Lingyun Xia, Qiwei Guo, Congcong Huang, Zidi Wang, Yinxuan Huang, Shanshan Qin, Weidong Leng, Dandan Li

Frontiers in Oncology

DOI

2022

Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs

Hedong Yu, Lingyun Xia, Xie-Yuan Leng, Yongji Chen, Li Zhang, Xiao-Bing Ni, Jie Denny Luo, Weidong Leng

Frontiers in Bioengineering and Biotechnology

DOI

2022

A Pan-Cancer Analysis Reveals the Prognostic and Immunotherapeutic Value of Stanniocalcin-2 (STC2)

Zhong-Hui Jiang, Xianfeng Shen, Yanhong Wei, Yongji Chen, Hongbo Chai, Lingyun Xia, Wei‐Dong Leng

Frontiers in Genetics

DOI

2021

口腔医学专业研究生教育质量评价体系的构建研究

夏凌云，杜阳，余和东，冷卫东

《卫生职业教育》

2021

Identifying Optimal Surgical Intervention-Based Chemotherapy for Gastric Cancer Patients With Liver Metastases

Min Sun, Hangliang Ding, Zhiqiang Zhu, Shengsheng Wang, Xinsheng Gu, Lingyun Xia, Tian Xiang Li

Frontiers in Oncology

DOI

2020

高龄老年人根尖周炎的诊治特点及显微手术治疗的临床疗效

毛敏，夏凌云，施俊，姚姮，倪小兵

《临床口腔医学杂志》

2020

三叶青提取物对口腔鳞状细胞癌生物学行为的体外研究

倪小兵，夏凌云，牛玉明，冷卫东，毛敏

《临床口腔医学杂志》

2020

3D打印成型纳米羟基磷灰石/壳聚糖/聚己内酯三元复合支架材料的构建及表征

余和东，张丽，夏凌云，毛敏，倪小兵，冷卫东，罗杰

《中国组织工程研究》

2020

Recovery of Oral In Vitro Biofilms after Exposure to Peptides and Chlorhexidine

Tian Zhang, Lingyun Xia, Zhejun Wang, Robert E. W. Hancock, Markus Haapasalo

Journal of Endodontics

DOI

2020

A nine-lncRNA signature predicts distant relapse-free survival of HER2-negative breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy

Min Sun, Xiaoxiao Liu, Lingyun Xia, Yuying Chen, Li Kuang, Xinsheng Gu, Tian Xiang Li

Biochemical Pharmacology

DOI

2019

腮腺肿瘤136例发病构成比分析

李艳琴，曾宪涛，夏凌云，倪小兵，艾俊，冷卫东

《临床口腔医学杂志》

2018

Frey综合征防治研究现状的文献计量学分析

冷卫东，刘小平，倪小兵，夏凌云，李艳琴，曾宪涛

《武警医学》

2018

Tooth Loss Is Associated With Increased Risk of Dementia and With a Dose-Response Relationship

Jun Chen, Chang-Ju Ren, Lan Wu, Lingyun Xia, Jun Shao, Wei‐Dong Leng, Xian‐Tao Zeng

Frontiers in Aging Neuroscience

DOI

2018

A novel hydroxyapatite-binding antimicrobial peptide against oral biofilms

Ying Yang, Lingyun Xia, Markus Haapasalo, Wei Wei, Duo Zhang, Jingzhi Ma, Ya Shen

Clinical Oral Investigations

DOI

2016

Periodontal Disease and Incident Lung Cancer Risk: A Meta‐Analysis of Cohort Studies

Xian‐Tao Zeng, Lingyun Xia, Yonggang Zhang, Sheng Li, Wei‐Dong Leng, Joey SW Kwong

Journal of Periodontology

DOI

2015

米诺环素软膏联合Vitapex治疗窦道型根尖周炎的临床观察

胡孝丽，张丽，许明莲，夏凌云，陈士龙

《临床口腔医学杂志》

2015

Cyclooxygenase-2–1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls

Donglai Deng, Lingyun Xia, Bing-Yang He, Jingmei Guo, Cui Huang, Xian‐Tao Zeng

Medical Science Monitor

DOI

2015

Meta‐Analysis of Association Between Interleukin‐1β C‐511T Polymorphism and Chronic Periodontitis Susceptibility

Xian‐Tao Zeng, Dong‐Yan Liu, Joey SW Kwong, Wei‐Dong Leng, Lingyun Xia, Min Mao

Journal of Periodontology

DOI

2014

基于间充质干细胞的舌鳞癌的基因治疗

夏凌云

《武汉大学》

2014

口腔根管治疗电子仿真实验教学模型的研制

贺维，冷卫东，罗志晓，胡孝丽，夏凌云，陈永吉，倪小兵，胡媛媛，刘彩云

《中国医学教育技术》

2014

[Meta analysis of the changes of regulatory T cell number in patients with active systemic lupus erythematosus].

Yonggang Xiang, Lingyun Xia, Xian‐Tao Zeng, Yong Zhang, Shengwu Liu

PubMed

2013

根管治疗期间急症发生机制及防治的研究进展

庞子燕，滕耀存，夏凌云，曾宪涛

《医学综述》

2013

Periodontal Disease and Risk of Head and Neck Cancer: A Meta-Analysis of Observational Studies

Xian‐Tao Zeng, Ai-Ping Deng, Cheng Li, Lingyun Xia, Yu‐Ming Niu, Wei‐Dong Leng

PLoS ONE

DOI

2012

突变型p53蛋白与P-糖蛋白在涎腺粘液表皮样癌中的表达及意义

贺维，倪小兵，毛敏，夏凌云，解龙川，冷卫东

《湖北医药学院学报》

2012

根管治疗期间急症发生的影响因素

徐畅，张超，曾宪涛，夏凌云

《医学综述》

2010

大锥度镍钛锉单独及与标准锥度联合使用在S形模拟根管中成形能力的比较

夏凌云，冷卫东，毛敏，王万芬，杨国彪，陈新梅

《实用口腔医学杂志》

2009

ProTaper锉预备S形模拟根管的成形效果观察

夏凌云，陈新梅，罗志晓，冷卫东，杨国彪

《实用口腔医学杂志》

2009

ProTaper锉预备S形弯曲模拟根管形态变化的连续观察

夏凌云，冷卫东，毛敏，杨国彪，项勇刚，陈新梅

《上海口腔医学》

2009

[Continuous observation of canal aberrations in S-shaped simulated root canal prepared by hand-used ProTaper files].

Lingyun Xia, Wei‐Dong Leng, Min Mao, Guobiao Yang, Yong-gang Xiang, Xinmei Chen

PubMed

2008

根充糊剂输送方式对糊剂分布模式的影响

郑黎薇，郝玉庆，杨国彪，夏凌云，陈菁，陈新梅

《实用口腔医学杂志》

2008

糊剂输送方式对根尖封闭性影响的研究

郑黎薇，张志强，郝玉庆，杨国彪，夏凌云，陈菁，陈新梅

《华西口腔医学杂志》

2008

根管治疗术中镍钛器械折断因素的研究进展

陈菁，夏凌云，陈新梅

《牙体牙髓牙周病学杂志》

精选作品

期刊论文

miR–185–5p通过IGFBP2调节口腔鳞状细胞癌细胞的增殖、凋亡

Efficacy and safety of diode laser in pulpotomy: a systematic review and meta-analysis

Vascular SMC-like CAF-derived THBS1 drives tumor-associated neutrophil recruitment to orchestrate an immunosuppressive microenvironment in gastric cancer

光学相干断层成像技术在口腔疾病诊断中的研究进展

EHBMT, a method for visualizing tumor evolution, identifies a surge in gastric cancer with hybrid epithelial–mesenchymal phenotypes due to an inflammatory microenvironment

Hypermethylation-mediated HNF4A silencing by Helicobacter pylori infection drives gastric cancer by disrupting epithelial cell polarity and activating EMT signaling

口腔颌面部肿瘤术后吞咽障碍的评估和康复管理专家共识

Cytotoxicity and Bone Biocompatibility of the C‐Root SP Experimental Root Canal Sealer

Receptor accessory protein 6, a novel ferroptosis suppressor, drives oral squamous cell carcinoma by maintaining endoplasmic reticulum hemostasis

Periosteum-bone inspired hierarchical scaffold with endogenous piezoelectricity for neuro-vascularized bone regeneration

lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1

Multifunctional polyurethane materials in regenerative medicine and tissue engineering

A novel TGFbeta/TGILR axis mediates crosstalk between cancer-associated fibroblasts and tumor cells to drive gastric cancer progression

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

Association between periodontitis and dental caries: a systematic review and meta-analysis

A new high-throughput screening methodology for the discovery of cancer-testis antigen using multi-omics data

Cancer-associated fibroblasts promote gastric cancer cell proliferation by paracrine FGF2-driven ribosome biogenesis

miR-124-3p.2通过CMTM6调控口腔鳞状细胞癌细胞凋亡、铁死亡的机制研究

牙隐裂综合征研究现状的文献计量学分析

Bacterial diversity in primary infected root canals of a Chinese cohort: analysis of 16 S rDNA sequencing

Fibromodulin overexpression drives oral squamous cell carcinoma via activating downstream EGFR signaling

Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis

Genome-wide association studies identify miRNA-194 as a prognostic biomarker for gastrointestinal cancer by targeting ATP6V1F, PPP1R14B, BTF3L4 and SLC7A5

Improved repair of rabbit calvarial defects with hydroxyapatite/chitosan/polycaprolactone composite scaffold-engrafted EPCs and BMSCs

A Pan-Cancer Analysis Reveals the Prognostic and Immunotherapeutic Value of Stanniocalcin-2 (STC2)

口腔医学专业研究生教育质量评价体系的构建研究

Identifying Optimal Surgical Intervention-Based Chemotherapy for Gastric Cancer Patients With Liver Metastases

高龄老年人根尖周炎的诊治特点及显微手术治疗的临床疗效

三叶青提取物对口腔鳞状细胞癌生物学行为的体外研究

3D打印成型纳米羟基磷灰石/壳聚糖/聚己内酯三元复合支架材料的构建及表征

Recovery of Oral In Vitro Biofilms after Exposure to Peptides and Chlorhexidine

A nine-lncRNA signature predicts distant relapse-free survival of HER2-negative breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy

腮腺肿瘤136例发病构成比分析

Frey综合征防治研究现状的文献计量学分析

Tooth Loss Is Associated With Increased Risk of Dementia and With a Dose-Response Relationship

A novel hydroxyapatite-binding antimicrobial peptide against oral biofilms

Periodontal Disease and Incident Lung Cancer Risk: A Meta‐Analysis of Cohort Studies

米诺环素软膏联合Vitapex治疗窦道型根尖周炎的临床观察

Cyclooxygenase-2–1195G>A Polymorphism and Head and Neck Squamous Cell Carcinoma Susceptibility: A Meta-Analysis of 1564 Cases and 2346 Controls

Meta‐Analysis of Association Between Interleukin‐1β C‐511T Polymorphism and Chronic Periodontitis Susceptibility

基于间充质干细胞的舌鳞癌的基因治疗

口腔根管治疗电子仿真实验教学模型的研制

[Meta analysis of the changes of regulatory T cell number in patients with active systemic lupus erythematosus].

根管治疗期间急症发生机制及防治的研究进展

Periodontal Disease and Risk of Head and Neck Cancer: A Meta-Analysis of Observational Studies

突变型p53蛋白与P-糖蛋白在涎腺粘液表皮样癌中的表达及意义

根管治疗期间急症发生的影响因素

大锥度镍钛锉单独及与标准锥度联合使用在S形模拟根管中成形能力的比较

ProTaper锉预备S形模拟根管的成形效果观察

ProTaper锉预备S形弯曲模拟根管形态变化的连续观察

[Continuous observation of canal aberrations in S-shaped simulated root canal prepared by hand-used ProTaper files].

根充糊剂输送方式对糊剂分布模式的影响

糊剂输送方式对根尖封闭性影响的研究

根管治疗术中镍钛器械折断因素的研究进展

会议论文

内化驱动式教学法在牙体牙髓病学融合课程思政教学中的设计与应用

STA无痛麻醉仪行牙周膜韧带麻醉在去髓术中的应用观察

手用ProTaper在预备S形模拟根管中成形效果的比较

一种根尖定位马达控制根管工作长度的准确性研究

研究方向