张敬仁｜清华大学｜学者主页

2026

Slc2a6 in Kupffer cells shapes host recognition of Streptococcus pneumoniae.

Mengtao Ding, Ye-Yang Liu, Haoran An, Li-Gong Chen, Jingren Zhang, Xiao-Yu Hu

Cell Reports

2026

Cell integrity preservation reduces impurity release and enables high-purity capsular polysaccharide production in Streptococcus pneumoniae

Siyuan Liu, Shuihong Cheng, Yanli Liu, Haotian Yao, Xin Cao, Jianlong Wang, Yi Zhao, Jing‐Ren Zhang, Jiankai Brent Liu, George F. Gao, Yuelong Li

Materials Today Advances

DOI

2026

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

Zhenglin Ji, Ji Gao, Shaocun Zhang, Jiajie Li, Haijing Wu, Jing Yao, Xianqiang Ma, Yue Xin, Yongjie Zhu, Meng Zhao, Zhidan Zhao, Kai Shen, Tao P. Wu, Xinmin Qian, Jinli Wang, Haoran An, Yuxin Li, Wenbo Sun, Qiancheng Zhao, Xiaoying Zhou, Ruiyu Gao, Qinghui Duan, Cuifeng Li, Xiaoke Geng, Ming Yang, Rong Xiao, Juan Liu, Wang Wang, Ji Wang, Yesheng Fu, Jing-Ren Zhang, Xiangjun Chen, Pei Tong, Gong Cheng, Hai Qi, Li Wu, Wenwen Zeng, Qiaoran Xi, Lingqiang Zhang, Yuping Lai, Wei Yang, Yonghui Zhang, Qianjin Lu, Wanli Liu

Nature

DOI

2026

Preclinical development of a well-defined semisynthetic glycoconjugate vaccine against Haemophilus influenzae type b

Wei Han, Chunjun Qin, Wei TONG, Kexin Yang, Xianbin Tian, Jing‐Ren Zhang, Jiankai Brent Liu, Peter H. Seeberger, Jing Hu, Jian Yin

Science Advances

DOI

2025

细菌多糖疫苗研究进展

黄荷淇，金倩，王娟娟，张敬仁

《药学学报》

DOI

2025

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions

Xiu-Yuan Li, Ping He, Shaomeng Wang, Yusong Wang, Dingfei Yan, Xiaohui Liu, Haiteng Deng, Zhixing Feng, Juanjuan Wang, Jing‐Ren Zhang

PLoS Pathogens

DOI

2025

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hong-Yu Zhou, Jiamin Wu, Qionghai Dai, Jing‐Ren Zhang

Science Advances

DOI

2025

Critical quality attributes and manufacturing techniques for Streptococcus pneumoniae capsular polysaccharide in pneumococcal vaccines: A review

Yuelong Li, Xueting Huang, Jin Qian, Jianlong Wang, Jing-Ren Zhang, Haifa Zheng

Carbohydrate Polymer Technologies and Applications

DOI

2025

C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria

Danyu Chen, Jiao Hu, Mengran Zhu, Yufeng Xie, Hantian Yao, Haoran An, Yumin Meng, Juanjuan Wang, Xueting Huang, Yanni Liu, Zhujun Shao, Ye Xiang, Jianxun Qi, George F. Gao, Jing‐Ren Zhang

The EMBO Journal

DOI

2025

Author response: Heat stress induces phage tolerance in Enterobacteriaceae

Fan Zhang, Haoze Chen, Bo Zheng, Liang Huang, Ye Xiang, Jing‐Ren Zhang, Jiafeng Liu

DOI

2025

Surface Plasmon Resonance for the Interaction of Capsular Polysaccharide (CPS) With KpACE

Zhe Wang, Lijun Wang, Xiaomin Zhang, Jing‐Ren Zhang, Chao Cai

BIO-PROTOCOL

DOI

2025

Development and immunological evaluation of a Streptococcus suis serotype 2 capsular polysaccharide conjugate vaccine

Yingjie Zhong, Huimin Yang, Wenqin Chai, Danyu Chen, Yannan Xue, Min Li, Xiongyan Meng, Shuai Meng, Jing-Ren Zhang, Chao Wu, Chengli Zong

Vaccine

DOI

2025

Molecular turn in Yersinia pestis pathogenesis: implications of the gppA frameshift for bacterial survival in human macrophage

Hongyan Chen, Shiyang Cao, Yazhou Zhou, Tong Wang, Yang Jiao, Yafang Tan, Yarong Wu, Yifan Ren, Yajun Song, Jing-Ren Zhang, Zongmin Du, Ruifu Yang

Emerging Microbes & Infections

DOI

2024

Isolation and characterization of three lytic podo-bacteriophages with two receptor recognition modules against multidrug-resistant Klebsiella pneumoniae

Liang Huang, Xueting Huang, Tongfei Zhao, Jingren Zhang, Ye Xiang

bioRxiv

DOI

2024

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms

Wen-Bo Sun, Ting-Yu Yang, Feng-Ming Sun, Pan-Hong Liu, Ji Gao, Xian-Mei Lan, Wei Xu, Yu-Hong Pang, Tong Li, Cui-Feng Li, Qing Liang, Hao-Ze Chen, Xiao-Hang Liu, Wen-Ting Tan, Huan-Huan Zhu, Fang-Yu Wang, Fan-Jun Cheng, Wei-Wei Zhai, Han-Na Kim, Jingren Zhang, Lin-Qi Zhang, Lu Lu, Qiao-Ran Xi, Guo-Hong Deng, Yan-Yi Huang, Xin Jin, Xiangjun Chen, Wan-Li Liu

Nature Immunology

DOI

2024

The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis

Shaomeng Wang, Xiu-Yuan Li, Mengran Zhu, Haiteng Deng, Juanjuan Wang, Jing‐Ren Zhang

PLoS Pathogens

DOI

2024

A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

Lijun Wang, Zhe Wang, Hua Zhang, Qian Jin, Shuaihua Fan, Yanni Liu, Xueting Huang, Jun Guo, Chao Cai, Jing‐Ren Zhang, Hui Wu

PLoS Pathogens

DOI

2024

Simplified process for preparing native and depolymerized capsular polysaccharides of Streptococcus pneumoniae

Yuelong Li, Hantian Yao, Yanli Liu, Xueting Huang, Xin Cao, Jianlong Wang, Zhixin Gao, Haifa Zheng, Jing-Ren Zhang, Jiankai Liu

Carbohydrate Polymers

DOI

2024

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

Xianbin Tian, Yanni Liu, Kun Zhu, Haoran An, Jie Feng, Linqi Zhang, Jing‐Ren Zhang

The Journal of Experimental Medicine

DOI

2024

Novel manufacturing process of pneumococcal capsular polysaccharides using advanced sterilization methods

Yuelong Li, Xin Cao, Xueting Huang, Yanli Liu, Jianlong Wang, Jin Qian, Jiankai Liu, Jing-Ren Zhang, Haifa Zheng

Frontiers in Bioengineering and Biotechnology

DOI

2024

In vivo functional immunoprotection correlates for vaccines against invasive bacteria

Xianbin Tian, Juanjuan Wang, Haoze Chen, Ming Ding, Jin Qian, Jing-Ren Zhang

Vaccine

DOI

2023

Emergence of the clinical rdar morphotype carbapenem-resistant and hypervirulent Klebsiella pneumoniae with enhanced adaption to hospital environment.

Cong-Cong Liu, Ning Dong, Xueting Huang, Zixian Huang, C. Cai, Jiayue Lu, Hong-Wei Zhou, Jingren Zhang, Yu Zeng, Fan Yang, Gong-Xiang Chen, Zhang-Qi Shen, Rong Zhang, Sheng Chen

Science of the Total Environment

DOI

2023

Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China

Yuan Zeng, Yu-Qin Song, Lan-Qing Cui, Qi Wu, Chao Wang, A. Coelho, Gang Zhang, Da-Wei Wei, Chao Li, Jingren Zhang, J. Corbeil, Yun Li, Jie Feng

Genome Medicine

DOI

2023

Two-Component Response Regulator OmpR Regulates Mucoviscosity through Energy Metabolism in Klebsiella pneumoniae

Lijun Wang, Xueting Huang, Qian Jin, Jie Tang, Hua Zhang, Jing-Ren Zhang, Hui Wu

Microbiology Spectrum

DOI

2023

Amino Acid Starvation-Induced Glutamine Accumulation Enhances Pneumococcal Survival

Chengwang Zhang, Yanhong Liu, Haoran An, Yuqin Wang, Lina Xu, Haiteng Deng, Songquan Wu, Jing-Ren Zhang, Xiaohui Liu

mSphere

DOI

2023

Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening

Haoran An, Xianbin Tian, Yijia Huang, Jing-Ren Zhang

STAR Protocols

DOI

2022

Serotype Distribution, Antimicrobial Susceptibility, Multilocus Sequencing Type and Virulence of Invasive Streptococcus pneumoniae in China: A Six-Year Multicenter Study

Meng-Lan Zhou, Ziran Wang, Li Zhang, T. Kudinha, Haoran An, C. Qian, Bin Jiang, Yao Wang, Ying-Chun Xu, Zheng-Yin Liu, H. Zhang, Jingren Zhang

Frontiers in Microbiology

DOI

2022

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

Xueting Huang, Xiuyuan Li, Haoran An, Juanjuan Wang, Ming Yu Ding, Lijun Wang, Lulu Li, Quanjiang Ji, Fen Qu, Hui Wang, Yingchun Xu, Xinxin Lu, Yuan He, Jing‐Ren Zhang

PLoS Pathogens

DOI

2022

Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation

Ziyi Guo, Haoqi Yang, Jing‐Ren Zhang, Wenwen Zeng, Xiaoyu Hu

Science Advances

DOI

2022

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

Haoran An, Chenyun Qian, Yijia Huang, Jing Li, Xianbin Tian, Jiaying Feng, Jiao Hu, Yujie Fang, Fangfang Jiao, Yuna Zeng, Xueting Huang, Xianbin Meng, Xue Liu, Xin Lin, Zhutian Zeng, Martin Guilliams, Alain Beschin, Yongwen Chen, Yuzhang Wu, Jing Wang, Marco Rinaldo Oggioni, John M. Leong, Jan‐Willem Veening, Haiteng Deng, Rong Zhang, Hui Wang, Jiang Wu, Yan Cui, Jing‐Ren Zhang

The Journal of Experimental Medicine

DOI

2021

A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors

Qingqing Hu, Huichun Tong, Jing Wang, Pupu Ge, Lin Zhu, Cuihua Liu, Jing‐Ren Zhang, Xiuzhu Dong

mBio

DOI

2021

MetR is a molecular adaptor for pneumococcal carriage in the healthy upper airway

Chengwang Zhang, Haoran An, Jiao Hu, Jing Li, Wenhao Zhang, Xun Lan, Haiteng Deng, Jing‐Ren Zhang

Molecular Microbiology

DOI

2020

In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae

Jing Li, Juanjuan Wang, Sofía Ruiz‐Cruz, Manuel Espinosa, Jing-Ren Zhang, Alicia Bravo

Frontiers in Molecular Biosciences

DOI

2020

Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems

Juanjuan Wang, Jing Li, Jing Li, Yijia Huang, Shaomeng Wang, Jing‐Ren Zhang

PLoS Pathogens

DOI

2020

Prevalence of phase variable epigenetic invertons among host-associated bacteria

Xueting Huang, Juanjuan Wang, Jing Li, Yanni Liu, Xue Liu, Zeyao Li, Kurni Kurniyati, Yijie Deng, Guilin Wang, Joseph D. Ralph, Megan De Ste Croix, Sara Escobar-Gonzalez, Richard J. Roberts, Jan‐Willem Veening, Xun Lan, Marco Rinaldo Oggioni, Chunhao Li, Jing-Ren Zhang

Nucleic Acids Research

DOI

2019

Phase Variation ofStreptococcus pneumoniae

Jing Li, Jing-Ren Zhang

Microbiology Spectrum

DOI

2019

Molecular Mechanisms of hsdS Inversions in the cod Locus of Streptococcus pneumoniae

Jing Li, Jing Li, Juanjuan Wang, Chunhao Li, Jing-Ren Zhang

Journal of Bacteriology

DOI

2019

HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation

Yanni Liu, Yuna Zeng, Yijia Huang, Lixiao Gu, Shaolin Wang, Chunhao Li, Donald A. Morrison, Haiteng Deng, Jing‐Ren Zhang

Molecular Microbiology

DOI

2018

Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation

Yu-Shan Pan, Haoran An, T. Fu, Shi-Yu Zhao, Chengwang Zhang, Gen-Hui Xiao, Jingren Zhang, Xinfang Zhao, Gong-Zheng Hu

BMC Microbiology

DOI

2018

Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen

Yang Wang, Zhensong Wen, Xiaolei Pan, David E. Briles, Yongqun Oliver He, Jing‐Ren Zhang

Infection and Immunity

DOI

2017

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

Xue Liu, Clément Gallay, Morten Kjos, Arnau Domenech, Jelle Slager, Sebastiaan P. van Kessel, Kèvin Knoops, Robin A. Sorg, Jing‐Ren Zhang, Jan‐Willem Veening

Molecular Systems Biology

DOI

2017

Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae

Xue Liu, Jing Li, Zhixing Feng, Youfu Luo, Jan‐Willem Veening, Jing-Ren Zhang

Journal of Bacteriology

DOI

2017

Observation of Pneumococcal Phase Variation in Colony Morphology

Jing Li, Juanjuan Wang, Fangfang Jiao, Jing‐Ren Zhang

BIO-PROTOCOL

DOI

2016

肺炎链球菌表型多样化的分子机制:遗传与表观遗传策略的共同作用

李靖，张敬仁

《中华临床实验室管理电子杂志》

2016

Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae

Zhensong Wen, Yanni Liu, Fen Qu, Jing‐Ren Zhang

Scientific Reports

DOI

2016

The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host

Lihong He, Manoj Kumar Mohan Nair, Yuling Chen, Xue Liu, Mengyun Zhang, Karsten R. O. Hazlett, Haiteng Deng, Jing‐Ren Zhang

Infection and Immunity

DOI

2015

Structural and Enzymatic Characterization of the Choline Kinase LicA from Streptococcus pneumoniae

Lei Wang, Yong‐Liang Jiang, Jing‐Ren Zhang, Cong‐Zhao Zhou, Yuxing Chen

PLoS ONE

DOI

2015

Sequence Elements Upstream of the Core Promoter Are Necessary for Full Transcription of the Capsule Gene Operon in Streptococcus pneumoniae Strain D39

Zhensong Wen, Odeniel Sertil, Yongxin Cheng, Shanshan Zhang, Xue Liu, Wen‐Ching Wang, Jing‐Ren Zhang

Infection and Immunity

DOI

2014

Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells

Yihu Yang, Yong‐Liang Jiang, Juan Zhang, Lei Wang, Xiao-Hui Bai, Shijie Zhang, Yan-Min Ren, Na Li, Yonghui Zhang, Zhiyong Zhang, Qingguo Gong, Yide Mei, Ting Xue, Jing-Ren Zhang, Yuxing Chen, Cong‐Zhao Zhou

PLoS Pathogens

DOI

2014

Structure of Pneumococcal Peptidoglycan Hydrolase LytB Reveals Insights into the Bacterial Cell Wall Remodeling and Pathogenesis

Xiao-Hui Bai, Huijie Chen, Yong‐Liang Jiang, Zhensong Wen, Yubin Huang, Cheng Wang, Qiong Li, Lei Qi, Jing‐Ren Zhang, Yuxing Chen, Cong‐Zhao Zhou

Journal of Biological Chemistry

DOI

2014

A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae

Xianfei Zeng, Yueyun Ma, Liu Yang, Lei Zhou, Yijuan Xin, Liang Chang, Jing‐Ren Zhang, Xiaoke Hao

Research in Microbiology

DOI

2014

Molecular basis of host specificity in human pathogenic bacteria

Xiaolei Pan, Yang Yang, Jing‐Ren Zhang

Emerging Microbes & Infections

DOI

2012

Complete Genome Sequence of Streptococcus pneumoniae Strain ST556, a Multidrug-Resistant Isolate from an Otitis Media Patient

Guiling Li, Fen Ze Hu, Xianwei Yang, Yujun Cui, Jun Yang, Fen Qu, George F. Gao, Jing‐Ren Zhang

Journal of Bacteriology

DOI

2012

The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism

Huiming Han, Cuihua Liu, Quanhui Wang, Chunling Xuan, Beiwen Zheng, Jiaqi Tang, Jinghua Yan, Jing‐Ren Zhang, Ming Li, Hao D. Cheng, Guangwen Lu, George F. Gao

Microbiology

DOI

2011

国内耐药肺炎链球菌的流行现状

姚开虎，张敬仁

《传染病信息》

2011

The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS

Jingliang Su, Rexford Asare, Jun Yang, Manoj Kumar Mohan Nair, Joseph Edward Mazurkiewicz, Yousef Abu Kwaik, Jing-Ren Zhang

Frontiers in Microbiology

DOI

2011

Insight into the Interaction of Metal Ions with TroA from Streptococcus suis

Beiwen Zheng, Qiangmin Zhang, Jia Gao, Huiming Han, Ming Li, Jing-Ren Zhang, Jianxun Qi, Jinghua Yan, George F. Gao

PLoS ONE

DOI

精选作品

期刊论文

Slc2a6 in Kupffer cells shapes host recognition of Streptococcus pneumoniae.

Cell integrity preservation reduces impurity release and enables high-purity capsular polysaccharide production in Streptococcus pneumoniae

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

Preclinical development of a well-defined semisynthetic glycoconjugate vaccine against Haemophilus influenzae type b

细菌多糖疫苗研究进展

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Critical quality attributes and manufacturing techniques for Streptococcus pneumoniae capsular polysaccharide in pneumococcal vaccines: A review

C-reactive protein is a broad-spectrum capsule-binding receptor for hepatic capture of blood-borne bacteria

Author response: Heat stress induces phage tolerance in Enterobacteriaceae

Surface Plasmon Resonance for the Interaction of Capsular Polysaccharide (CPS) With KpACE

Development and immunological evaluation of a Streptococcus suis serotype 2 capsular polysaccharide conjugate vaccine

Molecular turn in Yersinia pestis pathogenesis: implications of the gppA frameshift for bacterial survival in human macrophage

Isolation and characterization of three lytic podo-bacteriophages with two receptor recognition modules against multidrug-resistant Klebsiella pneumoniae

An IGHG1 variant exhibits polarized prevalence and confers enhanced IgG1 antibody responses against life-threatening organisms

The SpxA1-TenA toxin-antitoxin system regulates epigenetic variations of Streptococcus pneumoniae by targeting protein synthesis

A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

Simplified process for preparing native and depolymerized capsular polysaccharides of Streptococcus pneumoniae

Natural antibodies to polysaccharide capsules enable Kupffer cells to capture invading bacteria in the liver sinusoids

Novel manufacturing process of pneumococcal capsular polysaccharides using advanced sterilization methods

In vivo functional immunoprotection correlates for vaccines against invasive bacteria

Emergence of the clinical rdar morphotype carbapenem-resistant and hypervirulent Klebsiella pneumoniae with enhanced adaption to hospital environment.

Phylogenomic insights into evolutionary trajectories of multidrug resistant S. pneumoniae CC271 over a period of 14 years in China

Two-Component Response Regulator OmpR Regulates Mucoviscosity through Energy Metabolism in Klebsiella pneumoniae

Amino Acid Starvation-Induced Glutamine Accumulation Enhances Pneumococcal Survival

Identification of the mouse Kupffer cell receptors recognizing pneumococcal capsules by affinity screening

Serotype Distribution, Antimicrobial Susceptibility, Multilocus Sequencing Type and Virulence of Invasive Streptococcus pneumoniae in China: A Six-Year Multicenter Study

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

Leptin receptor signaling sustains metabolic fitness of alveolar macrophages to attenuate pulmonary inflammation

Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria

A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors

MetR is a molecular adaptor for pneumococcal carriage in the healthy upper airway

In vitro DNA Inversions Mediated by the PsrA Site-Specific Tyrosine Recombinase of Streptococcus pneumoniae

Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems

Prevalence of phase variable epigenetic invertons among host-associated bacteria

Phase Variation ofStreptococcus pneumoniae

Molecular Mechanisms of hsdS Inversions in the cod Locus of Streptococcus pneumoniae

HtrA‐mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation

Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation

Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae

Observation of Pneumococcal Phase Variation in Colony Morphology

肺炎链球菌表型多样化的分子机制:遗传与表观遗传策略的共同作用

Allelic Variation of the Capsule Promoter Diversifies Encapsulation and Virulence In Streptococcus pneumoniae

The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host

Structural and Enzymatic Characterization of the Choline Kinase LicA from Streptococcus pneumoniae

Sequence Elements Upstream of the Core Promoter Are Necessary for Full Transcription of the Capsule Gene Operon in Streptococcus pneumoniae Strain D39

Structural Insights into SraP-Mediated Staphylococcus aureus Adhesion to Host Cells

Structure of Pneumococcal Peptidoglycan Hydrolase LytB Reveals Insights into the Bacterial Cell Wall Remodeling and Pathogenesis

A C-terminal truncated mutation of licC attenuates the virulence of Streptococcus pneumoniae

Molecular basis of host specificity in human pathogenic bacteria

Complete Genome Sequence of Streptococcus pneumoniae Strain ST556, a Multidrug-Resistant Isolate from an Otitis Media Patient

The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism

国内耐药肺炎链球菌的流行现状

The capBCA Locus is Required for Intracellular Growth of Francisella tularensis LVS

Insight into the Interaction of Metal Ions with TroA from Streptococcus suis

会议论文

外膜泡介导酯酶FtlA分泌促进土拉弗朗西斯菌对宿主细胞的侵染

Revelation of Bacterial Methylome in the Genomics Era

肺炎链球菌R6的ABC转运蛋白ProWX的结构和功能研究

预印本

Heat Stress Induces Phage Tolerance in Bacteria

Heat Stress Induced Bacterial Tolerance against Phage Facilitates the Evolution of Resistance

Influenza Virus Enhances Bacterial Growth in the Lungs through Weakening Capsule Receptor-Mediated Bacterial Capture by Neutrophils

C-Reactive Protein Drives Potent Clearance of Blood Bacteria in the Liver by Activating the Complement System

Pathogen Clearance-based Correlates of Immunoprotection Reveal Insightful Features of Vaccine Immunity

书籍章节

Molecular medical microbiology—from bench to bedside

Bacterial capsules

Structural Comparison and Simulation of Pneumococcal Peptidoglycan Hydrolase LytB

Bacterial Capsules

研究方向