倪挺｜复旦大学｜学者主页

2026

Structural decomposition enables multi-omics dissection of common and organ-specific aging

Huang He, Yi Li, Qinglin Song, Liyun Yuan, Yuqi Yang, Minwei Zhu, Renliang Sun, Yue Hu, Chenyihang Xiong, Ting Ni, Yun Liu, Andrés Ruiz‐Linares, Guoqing Zhang, Fan Liu, Qianqian Peng, Sijia Wang

Science China Life Sciences

DOI

2026

Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states.

Xiaolan Zhou, Limin Lin, Yu Chen, Guang Yang, Ting Ni, Zhaozhao Zhao

Science China Life Sciences

DOI

2026

The gut as a central hub for multi-organ crosstalk in aging

Xianhong Zhang, Rongqing Li, Yue Gao, Wen-Jia Zhang, Ting Ni, Yong-Bin Liu

Cellular and Molecular Life Sciences (CMLS)

DOI

2026

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni

Aging Cell

DOI

2026

BioGAIP: a scalable and robust LLM-powered multi-agent system for automated bioinformatics tasks.

Jia-Yu Zhang, Peng-Fei Guo, Guang-Hui Jiang, Meng-Yu Zhou, Gang Wei, Ting Ni

Journal of genetics and genomics = Yi chuan xue bao

DOI

2026

Multi-layer transcriptomic characterization of age-related immune dynamics

Zhaozhao Zhao, Shu-Wen Zhao, Jun Jin, Ting Ni

bioRxiv

DOI

2026

Decoding exercise-induced delayed aging from a single-cell perspective

Yuqi Zhao, Xiaolan Zhou, Ting Ni

Advanced Exercise and Health Science

DOI

2025

细胞衰老在器官衰老中的作用和调控

倪挺，蒋光辉，李学文，龙娟，沈之力，王灵仙，张静菲，赵昭昭

《老年医学与保健》

2025

3' untranslated region somatic variants connect alternative polyadenylation dysregulation in human cancers.

Qiushi Xu, Xiaomeng Cheng, Qianru Li, Peng Yu, Xiaolan Zhou, Yu Chen, Limin Lin, Ting Ni, Zhaozhao Zhao

Journal of genetics and genomics = Yi chuan xue bao

DOI

2025

The Regulation of Cellular Senescence in Cancer

Xianhong Zhang, Yue Gao, Si-Yu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni

Biomolecules

DOI

2025

Reduced Usage of GLS Intronic Polyadenylation Promotes Cellular Senescence

Xue-Ping Li, Yu-Xin Li, Dong Ding, Baiyun Xie, Jun Yao, Yu Chen, Zhaozhao Zhao, Peng Yu, Sheng-Wei Zhang, Fu Yang, Ting Ni, Gang Wei

Phenomics

DOI

2025

Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers

Xu-Dong Zou, Zhaozhao Zhao, Yu Chen, Kewei Xiong, Zeyang Wang, Shu-Xing Chen, Hui Chen, Gong-Hong Wei, Shu-Hua Xu, Wei Li, Ting Ni, Lei Li

Nature Communications

DOI

2025

Mitochondrial dysfunction in the regulation of aging and aging-related diseases

Xianhong Zhang, Yue Gao, Si-Yu Zhang, Yi-Qi Wang, Xin Pei, Yu-Fei Chen, Jinhui Zhang, Yichen Zhang, Yitian Du, S. Hao, Yu-Jiong Wang, Ting Ni

Cell Communication and Signaling

DOI

2025

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions

Jing Wang, Xiaolan Zhou, Peng Yu, Jun Yao, Pengfei Guo, Qiushi Xu, Yuqi Zhao, Guan-Long Wang, Qianru Li, Xiaofeng Zhu, Gang Wei, Weixu Wang, Ting Ni

Nature Aging

DOI

2025

SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

Zhang Xianhong, Yue Gao, Yu Zhang, Zhang Yichen, Chen Yufei, Pei Xinke, Zhang Jinhui, Yiqi Wang, Yitian Du, Hao Shuailin, Ting Ni

Communications Biology

DOI

2024

The landscape and clinical relevance of intronic polyadenylation in human cancers.

Xiaomeng Cheng, G. Jiang, Xiaolan Zhou, Jing Wang, Zhaozhao Zhao, Jia-Yu Zhang, Ting Ni

Journal of genetics and genomics = Yi chuan xue bao

DOI

2024

Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma

Haoyu Li, Xiao-Xiao Sun, Yuan-Yuan Lv, Gang Wei, Ting Ni, Wen-Xin Qin, Haojie Jin, Qi Jia

Current Issues in Molecular Biology

DOI

2024

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Hui Chen, Zeyang Wang, Lihai Gong, Qi-Xuan Wang, Wenyan Chen, Jia Wang, Xue-Lian Ma, Ruofan Ding, Xing Li, Xu-Dong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li

Nature Communications

DOI

2024

Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis

Yue Gao, Si-Yu Zhang, Xianhong Zhang, Yitian Du, Ting Ni, Shuailin Hao

iScience

DOI

2024

The Tumor Microenvironment: Signal Transduction

Xianhong Zhang, Hai-Jun Ma, Yue Gao, Ya-Bing Liang, Yitian Du, Shuailin Hao, Ting Ni

Biomolecules

DOI

2024

Deficiency of Gut-Enriched Lipase H Promotes Gut Aging and Reduces Lifespan in Drosophila

Yinghui Sun, Haijing Ma, Xiaolan Zhou, Leihuan Huang, Peng Yu, Yun Qi, Gang Wei, Ting Ni

Phenomics

DOI

2024

Pan-cancer transcriptome analysis reveals widespread regulation through alternative tandem transcription initiation

Zhaozhao Zhao, Yu Chen, Xu-Dong Zou, Limin Lin, Xiaolan Zhou, Xiaomeng Cheng, Guangrui Yang, Qiushi Xu, Lihai Gong, Lei Li, Ting Ni

Science Advances

DOI

2024

Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies

Xiaolan Zhou, Xiaofeng Zhu, Weixu Wang, Jing Wang, Haimei Wen, Yuqi Zhao, Jiayu Zhang, Qiushi Xu, Zhaozhao Zhao, Ting Ni

Research

DOI

2024

Cellular senescence induced by down-regulation of PTBP1 correlates with exon skipping of mitochondrial-related gene NDUFV3

Yu Yang, Haimei Wen, Yuxin Li, Xin Zeng, Gang Wei, Zhenglong Gu, Ting Ni

Life Medicine

DOI

2023

肾脏VDR表达与衰老密切相关-来自多个数据库的综合分析

吴好，周小兰，倪挺，游怀舟，陈靖

《老年医学与保健》

2023

Integrative analysis of Iso-Seq and RNA-seq reveals dynamic changes of alternative promoter, alternative splicing and alternative polyadenylation during Angiotensin II-induced senescence in rat primary aortic endothelial cells

Hai-Xu Wen, Wei Chen, Yu Chen, Gang Wei, Ting Ni

Frontiers in Genetics

DOI

2023

The Role of Tumor Metabolic Reprogramming in Tumor Immunity

Xianhong Zhang, Wei-Guo Song, Yue Gao, Yu Zhang, Yuqi Zhao, Shuailin Hao, Ting Ni

International Journal of Molecular Sciences

DOI

2023

The landscape of cryptic antisense transcription in human cancers reveals an oncogenic noncoding RNA in lung cancer

Zhaozhao Zhao, Yu Chen, Xiaomeng Cheng, Leihuan Huang, Hai-Xu Wen, Qiushi Xu, Xiaoping Zhou, Xiaoyang Zhang, Jing Chen, Ting Ni

Science Advances

DOI

2023

Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple‐negative breast cancer to immune checkpoint inhibitors

Xin-Yu Chen, Bin Li, Ye Wang, Juan Jin, Yu Yang, Leihuan Huang, Meng-Di Yang, Jian Zhang, Bi-Yun Wang, Z. Shao, Ting Ni, Shenglin Huang, Xi-Chun Hu, Z. Tao

Cancer Communications

DOI

2023

Approximate estimation of cell-type resolution transcriptome in bulk tissue through matrix completion

Weixu Wang, Xiaoping Zhou, Jing Wang, Jun Yao, Hai-Xu Wen, Yi Wang, Mingwan Sun, Chao Zhang, W. Tao, J. Zou, Ting Ni

Briefings Bioinform.

DOI

2023

Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis

Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni

Cancers

DOI

2022

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression

T. Shen, Ting Ni, Jiaxuan Chen, Hai-Tao Chen, Xiao-Pin Ma, Guang-Wen Cao, Tianzhi Wu, Hai-Sheng Xie, Bin Zhou, Gang Wei, H. Saiyin, Suqin Shen, YU Peng, Qian-Yi Xiao, Hui Liu, Yu-Zhen Gao, Xi-Dai Long, Jian-Rong Yin, Yanfang Guo, Jiaxue Wu, Gong-Hong Wei, Jin-Lin Hou, Deke Jiang

Nature Communications

DOI

2022

Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity

Zhenghua Su, Haibi Su, Jie Xu, Gang Wei, Lefeng Qu, Ting Ni, Di Yang, Yi-Zhun Zhu

Aging

DOI

2022

ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues

Xue-Lian Ma, Shumin Cheng, R. Ding, Zhaozhao Zhao, Xu-Dong Zou, Shou-Hong Guang, Qi-Xuan Wang, Huan Jing, Chen Yu, Ting Ni, Lei Li

Nucleic Acids Res.

DOI

2022

E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma

Meng Chen, Zhaozhao Zhao, Lian-Qun Wu, Jian-Cheng Huang, YU Peng, Jiang Qian, Ting Ni, Chen Zhao

Cell Death and Disease

DOI

2021

剪接因子异质核糖核蛋白A2B1在癌细胞和衰老细胞中的相反表达趋势及其对癌细胞衰老的调控（英文）

曹君红，陈蒙，贾琦，赵昭昭，文海梅，姚钧，余鹏，马海静，倪挺，魏刚

《中国生物化学与分子生物学报》

DOI

2021

“基因转录调控的奥秘”微课教案

倪挺

《高校生物学教学研究(电子版)》

2021

Independent component analysis based gene co-expression network inference (ICAnet) to decipher functional modules for better single-cell clustering and batch integration

Weixu Wang, Huanhuan Tan, Mingwan Sun, Yi Han, Wei Chen, Shengnu Qiu, Ke Zheng, Gang Wei, Ting Ni

Nucleic Acids Research

DOI

2021

Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data

Zhaozhao Zhao, Qiushi Xu, Ran Wei, Weixu Wang, D. Ding, Yu Yang, Jun Yao, Li-Ye Zhang, Yue-Qing Hu, Gang Wei, Ting Ni

Genome Research

DOI

2021

Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers

Zhaozhao Zhao, Qiushi Xu, Ran Wei, Leihuan Huang, Weixu Wang, Gang Wei, Ting Ni

Nucleic Acids Research

DOI

2021

Improved estimation of cell type-specific gene expression through deconvolution of bulk tissues with matrix completion

Weixu Wang, Jun Yao, Yi Wang, Chao Zhang, W. Tao, J. Zou, Ting Ni

2021

Lung cancer cells expressing a shortened CDK16 3′UTR escape senescence through impaired miR‐485‐5p targeting

Qi Jia, Baiyun Xie, Zhaozhao Zhao, Leihuan Huang, Gang Wei, Ting Ni

Molecular Oncology

DOI

2021

Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes

Meng Chen, Ran Wei, Gang Wei, Ming-Qing Xu, Zhi-Xi Su, Chen Zhao, Ting Ni

Genome Research

DOI

2021

Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

Jun-Liang Wang, Wei Chen, Wen-Jun Yue, W. Hou, Feng Rao, Han-Bing Zhong, Yuan-Ming Qi, Ni Hong, Ting Ni, Wenfei Jin

bioRxiv

DOI

2020

小鼠精子发生中环形RNA生成和功能分析

宋逸钒，倪挺，魏刚

《生物信息学》

2020

SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation

Fen Long, Di Yang, Jinghuan Wang, Qing Wang, Ting Ni, Gang Wei, Yi-Zhun Zhu, Xinhua Liu

Acta Pharmaceutica Sinica B

DOI

2020

Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.

Li-Li Wang, Meng Chen, Haihui Fu, Ting Ni, Gang Wei

Biochemical and Biophysical Research Communications - BBRC

DOI

2020

Corrigendum: 3′ UTR lengthening as a novel mechanism in regulating cellular senescence

Meng Chen, Guoliang Lyu, Miao Han, Hong-Bo Nie, T. Shen, Wei Chen, Yi-Chi Niu, Yi-Fan Song, Xue-Ping Li, Huan Li, Xin-Yu Chen, Zi-Yue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yu-Fang Zheng, Xin-Hua Liu, Jin-Feng Hu, Gang Wei, W. Tao, Ting Ni

Genome Research

DOI

2020

Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence

Jun Yao, D. Ding, Xue-Ping Li, T. Shen, Haihui Fu, H. Zhong, Gang Wei, Ting Ni

Aging Cell

DOI

2020

Histone methyltransferase Smyd3 is a new regulator for vascular senescence

Di Yang, Gang Wei, Fen Long, Hong-Bo Nie, Xiaoli Tian, L. Qu, Shuang-Xi Wang, Peng Li, Yue Qiu, Yang Wang, W. Hong, Ting Ni, Xinhua Liu, Yi-Zhun Zhu

Aging Cell

DOI

2020

Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging

Di Yang, Qing Wang, Gang Wei, Jiaxue Wu, Yi Chun Zhu, Qing Zhu, Ting Ni, Xinhua Liu, Yi Zhu

Aging

DOI

2020

Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers

Ran Wei, Pengcheng Li, Funan He, Gang Wei, Zhan Zhou, Zhi-Xi Su, Ting Ni

Briefings Bioinform.

DOI

2020

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

Wei Chen, Xuefei Wang, Gang Wei, Yin Huang, Yu-Fang Shi, Dan Li, Shengnu Qiu, Bin Zhou, Jun-Hong Cao, Meng Chen, Peng-Fei Qin, Wenfei Jin, Ting Ni

Frontiers in Genetics

DOI

2019

HNRNPA1-mediated 3′ UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes

Qi Jia, Hong-Bo Nie, YU Peng, Baiyun Xie, Chen-Ji Wang, Fu Yang, Gang Wei, Ting Ni

Aging

DOI

2019

Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells.

Xue-Ping Li, D. Ding, Jun Yao, Bin Zhou, T. Shen, Yun Qi, Ting Ni, Gang Wei

Life Science

DOI

2019

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence

T. Shen, Huan Li, Yifan Song, Li Li, Jinzhong Lin, Gang Wei, Ting Ni

Aging

DOI

2018

3′ UTR lengthening as a novel mechanism in regulating cellular senescence

Meng Chen, Guoliang Lyu, Miao Han, Hong-Bo Nie, T. Shen, Wei Chen, Yichi Niu, Yifan Song, Xue-Ping Li, Huan Li, Xin-Yu Chen, Zi-Yue Wang, Zheng Xia, Wei Li, Xiao-Li Tian, Chen Ding, Jun Gu, Yu-Fang Zheng, Xinhua Liu, Jin-Feng Hu, Gang Wei, W. Tao, Ting Ni

Genome Research

DOI

2018

Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence.

Qi Jia, Hong-Bo Nie, Xue-Chao Wan, Haihui Fu, Fu Yang, Yao Li, Gang Wei, Ting Ni

Biochemical and Biophysical Research Communications - BBRC

DOI

2017

Antisense transcription regulates the expression of sense gene via alternative polyadenylation

T. Shen, Huan Li, Yifan Song, Jun Yao, Miao Han, Ming Yu, Gang Wei, Ting Ni

Protein & Cell

DOI

2017

Alternative Polyadenylation: Methods, Findings, and Impacts

Wei Chen, Qi Jia, Yifan Song, Haihui Fu, Gang Wei, Ting Ni

Genomics, Proteomics & Bioinformatics

DOI

2017

Alternative splicing in aging and age-related diseases

Huan Li, Zi-Yue Wang, Tianyi Ma, Gang Wei, Ting Ni

DOI

2016

Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells

Xiwen Lin, Miao Han, Lu Cheng, Jian Chen, Zhu-Qiang Zhang, T. Shen, Min Wang, Bo Wen, Ting Ni, Chun-Sheng Han

RNA Biology

DOI

2015

p38-p53-p21信号通路参与调控血管紧张素-Ⅱ诱导的人血管平滑肌细胞衰老

廉亚茹，刘新华，韩苗，潘礼龙，胡金锋，魏刚，倪挺

《复旦学报(自然科学版)》

2015

An intriguing RNA species—perspectives of circularized RNA

T. Shen, Miao Han, Gang Wei, Ting Ni

Protein & Cell

DOI

2015

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

Miao Han, G. Lv, Hong-Bo Nie, T. Shen, Yichi Niu, Xue-Ping Li, Meng Chen, Xia Zheng, Wei Li, Chen Ding, Gang Wei, Jun Gu, Xiao-Li Tian, Yu-Fang Zheng, Xin-Hua Liu, Jin-Feng Hu, W. Tao, Ting Ni

bioRxiv

DOI

2015

Global lengthening of 3ʹ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

Miao Han, G. Lv, Hong-Bo Nie, T. Shen, Yichi Niu, Xue-Ping Li, Meng Chen, Xia Zheng, Wei Li, Chen Ding, Gang Wei, Jun Gu, Xiao-Li Tian, Yu-Fang Zheng, Xinhua Liu, Jin-Feng Hu, W. Tao, Ting Ni

bioRxiv

DOI

2013

Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

Ting Ni, Yan-Qin Yang, D. Hafez, Wenjing Yang, Kurtis Kiesewetter, Y. Wakabayashi, U. Ohler, Wei-Qun Peng, Jun Zhu

BMC Genomics

DOI

2013

Genetic heterogeneity of diffuse large B-cell lymphoma

Jenny Zhang, V. Grubor, C. Love, A. Banerjee, K. Richards, P. Mieczkowski, C. Dunphy, W. Choi, Wing-Yan Au, G. Srivastava, P. Lugar, D. Rizzieri, A. Lagoo, L. Bernal-Mizrachi, K. Mann, C. Flowers, Kikkeri N. Naresh, A. Evens, L. Gordon, M. Czader, J. Gill, E. Hsi, Qing-Quan Liu, Alice C. Fan, K. Walsh, Dereje D. Jima, Lisa L. Smith, A. Johnson, J. Byrd, M. Luftig, Ting Ni, Jun Zhu, A. Chadburn, S. Levy, D. Dunson, S. Dave

Proceedings of the National Academy of Sciences of the United States of America

DOI

2013

Genome-wide identification and predictive modeling of tissue-specific alternative polyadenylation

D. Hafez, Ting Ni, Sayan Mukherjee, Jun Zhu, U. Ohler

Bioinform.

DOI

2013

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

Eric Wang, S. Kawaoka, Ming Yu, Junwei Shi, Ting Ni, Wenjing Yang, Jun Zhu, R. Roeder, Christopher R. Vakoc

Proceedings of the National Academy of Sciences of the United States of America

DOI

2012

The genetic landscape of immune-competent and HIV lymphoma

Jenny Zhang, V. Grubor, C. Love, A. Banerjee, K. Richards, Piotr Miezcowski, C. Dunphy, W. Choi, Wing-Yan Auv, G. Srivastava, P. Lugar, D. Rizzieri, A. Lagoo, L. Bernal-Mizrachi, K. Mann, C. Flowers, Kikkeri N. Naresh, A. Evens, L. Gordon, M. Czader, J. Gill, E. Hsi, Qing-Quan Liu, Alice C. Fan, K. Walsh, Dereje D. Jima, M. Luftig, Ting Ni, Jun Zhu, A. Chadburn, S. Levy, D. Dunson, S. Dave

Infectious Agents and Cancer

DOI

2011

Transcriptome-Wide Analysis of Polyadenylation Sites in Mantle Cell Lymphoma Using Polyadenylation Signal Sequencing,

M. Weniger, De-Long Liu, Ting Ni, Jun Zhu, A. Wiestner

DOI

精选作品

期刊论文

Structural decomposition enables multi-omics dissection of common and organ-specific aging

Unannotated noncoding transcripts as a source of intratumor heterogeneity in malignant cell states.

The gut as a central hub for multi-organ crosstalk in aging

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

BioGAIP: a scalable and robust LLM-powered multi-agent system for automated bioinformatics tasks.

Multi-layer transcriptomic characterization of age-related immune dynamics

Decoding exercise-induced delayed aging from a single-cell perspective

细胞衰老在器官衰老中的作用和调控

3' untranslated region somatic variants connect alternative polyadenylation dysregulation in human cancers.

The Regulation of Cellular Senescence in Cancer

Reduced Usage of GLS Intronic Polyadenylation Promotes Cellular Senescence

Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers

Mitochondrial dysfunction in the regulation of aging and aging-related diseases

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions

SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

The landscape and clinical relevance of intronic polyadenylation in human cancers.

Downregulation of Splicing Factor PTBP1 Curtails FBXO5 Expression to Promote Cellular Senescence in Lung Adenocarcinoma

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis

The Tumor Microenvironment: Signal Transduction

Deficiency of Gut-Enriched Lipase H Promotes Gut Aging and Reduces Lifespan in Drosophila

Pan-cancer transcriptome analysis reveals widespread regulation through alternative tandem transcription initiation

Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies

Cellular senescence induced by down-regulation of PTBP1 correlates with exon skipping of mitochondrial-related gene NDUFV3

肾脏VDR表达与衰老密切相关-来自多个数据库的综合分析

Integrative analysis of Iso-Seq and RNA-seq reveals dynamic changes of alternative promoter, alternative splicing and alternative polyadenylation during Angiotensin II-induced senescence in rat primary aortic endothelial cells

The Role of Tumor Metabolic Reprogramming in Tumor Immunity

The landscape of cryptic antisense transcription in human cancers reveals an oncogenic noncoding RNA in lung cancer

Low level of ARID1A contributes to adaptive immune resistance and sensitizes triple‐negative breast cancer to immune checkpoint inhibitors

Approximate estimation of cell-type resolution transcriptome in bulk tissue through matrix completion

Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression

Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity

ipaQTL-atlas: an atlas of intronic polyadenylation quantitative trait loci across human tissues

E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma

剪接因子异质核糖核蛋白A2B1在癌细胞和衰老细胞中的相反表达趋势及其对癌细胞衰老的调控（英文）

“基因转录调控的奥秘”微课教案

Independent component analysis based gene co-expression network inference (ICAnet) to decipher functional modules for better single-cell clustering and batch integration

Cancer-associated dynamics and potential regulators of intronic polyadenylation revealed by IPAFinder using standard RNA-seq data

Comprehensive characterization of somatic variants associated with intronic polyadenylation in human cancers

Improved estimation of cell type-specific gene expression through deconvolution of bulk tissues with matrix completion

Lung cancer cells expressing a shortened CDK16 3′UTR escape senescence through impaired miR‐485‐5p targeting

Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes

Comprehensive mapping of alternative polyadenylation site usage and its dynamics at single-cell resolution

小鼠精子发生中环形RNA生成和功能分析

SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation

Tempo-spatial alternative polyadenylation analysis reveals that 3' UTR lengthening of Mdm2 regulates p53 expression and cellular senescence in aged rat testis.

Corrigendum: 3′ UTR lengthening as a novel mechanism in regulating cellular senescence

Prevalent intron retention fine‐tunes gene expression and contributes to cellular senescence

Histone methyltransferase Smyd3 is a new regulator for vascular senescence

Smyd3-PARP16 axis accelerates unfolded protein response and vascular aging

Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers

Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts

HNRNPA1-mediated 3′ UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes

Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells.

Alternative polyadenylation dependent function of splicing factor SRSF3 contributes to cellular senescence

3′ UTR lengthening as a novel mechanism in regulating cellular senescence

Down-regulation of cancer-associated gene CDC73 contributes to cellular senescence.

Antisense transcription regulates the expression of sense gene via alternative polyadenylation

Alternative Polyadenylation: Methods, Findings, and Impacts

Alternative splicing in aging and age-related diseases

Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells

p38-p53-p21信号通路参与调控血管紧张素-Ⅱ诱导的人血管平滑肌细胞衰老

An intriguing RNA species—perspectives of circularized RNA

Progressive lengthening of 3′ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence of mouse embryonic fibroblasts

Global lengthening of 3ʹ untranslated regions of mRNAs by alternative cleavage and polyadenylation in cellular senescence

Distinct polyadenylation landscapes of diverse human tissues revealed by a modified PA-seq strategy

Genetic heterogeneity of diffuse large B-cell lymphoma

Genome-wide identification and predictive modeling of tissue-specific alternative polyadenylation

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

The genetic landscape of immune-competent and HIV lymphoma

Transcriptome-Wide Analysis of Polyadenylation Sites in Mantle Cell Lymphoma Using Polyadenylation Signal Sequencing,

预印本

Quantitative Insights into Common and Organ-Specific Aging Gaps via Integrated Multi-Omics Analysis

Organ Function-Derived Protein Clocks Demonstrate Enhanced Prediction of Organ-Specific Disease and Mortality Risk

研究方向