许韧｜厦门大学｜学者主页

2026

Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche

Zihan Chen, Zhengqiong Luo, Matthew Blake Greenblatt, Zuoxing Wu, Ren Xu

Bone Research

2026

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Long Zhang, Yu Chen, Xueqing Shi, Taifeng Zhou, Jie Han, Lin Meng, Na Li, Matthew Blake Greenblatt, Zemin Ling, Peiqiang Su, Fuxin Wei, Ren Xu

Nature Communications

DOI

2026

Sex hormones and their receptors in osteoarthritis: current research progress

Ziwei Wang, Xueqing Shi, Ge Yang, Kai Zheng, Ren Xu

Annals of Joint

DOI

2026

Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia

Shang-Hui Ye, Lian-Jie Li, Yi-Jiao Wang, Cheng-Run Yuan, Jie Han, Dan He, Lin Che, Xiao-Hui Chen, Rong Shen, Jie Yang, Matthew Blake Greenblatt, Yang Xian-xian, Jian-Min Huang, Jing Chen, Ren Xu

Bioactive Materials

DOI

2026

Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging

Zhuoning Miao, Ziyang Tong, Linjing Shi, Fei Yang, Tao Zhang, Chunmei Fan, Tian Qin, Jia Gao, Qiangqiang Zheng, Xianan Mo, Hongwei Ouyang, 殷姿, Ren Xu, Yi Zhou, Xiao Chen

Nature Communications

DOI

2025

Advances in spatial transcriptomics and its application in the musculoskeletal system

Haoyu Wang, Peng Cheng, Juan Wang, Hongzhi Lv, Jie Han, Zhiyong Hou, Ren Xu, Wei Chen

Bone Research

DOI

2025

Tirzepatide, a dual GLP-1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial-related metabolites

Ning Chen, Mengdan Zhang, Baohong Shi, Xiumei Luo, Rui Huang, Zhengqiong Luo, Junliang He, Shengye Xue, Na Li, Zemin Ling, Hao Guo, Ren Xu, Yuejun Liu

Journal of Orthopaedic Translation

DOI

2025

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization

Yijie Gao, Rui Zhou, Xixi Lin, Zhijuan Liu, Yuangang Su, Haoyu Lian, Bin Lin, Xiaofei Ding, Shijie Liao, Xiangde Li, Jinmin Zhao, Jiake Xu, Ren Xu, Qian Liu, Fangming Song

Journal of Translational Medicine

DOI

2025

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Chun‐Lan Xie, S Ye, Yu‐Ting Yue, Baohong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew Blake Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu

Advanced Science

DOI

2025

RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway

Han Wang, Xiwen Yuan, Jie Han, Zuoxing Wu, Ziyao Ma, Fan Shi, Zhengqiong Luo, Zihan Chen, Chenyang Guo, Guixin Yuan, Xuemei He, Zemin Ling, Lin Meng, Rong Shen, Jianming Huang, Ren Xu

Journal of Orthopaedic Translation

DOI

2025

Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease

Fan Shi, Guixin Yuan, Zuoxing Wu, Zhengqiong Luo, Zihan Chen, Qian Liu, Na Li, Ren Xu

Journal of Orthopaedic Translation

DOI

2025

Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy

Jing Chen, Dan He, Chengrun Yuan, Na Li, Baohong Shi, Conway Niu, Jiangfei Yang, Liangkai Zheng, Lin Che, Ren Xu

Journal of Orthopaedic Translation

DOI

2025

Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation

Zuoxing Wu, Na Li, Zhengqiong Luo, Zihan Chen, Xuemei He, Jie Han, Xixi Lin, Fan Shi, Haitao Huang, Baohong Shi, Yu Li, Xin Wang, Lin Meng, Dachuan Zhang, Lanfen Chen, Dawang Zhou, Weinan Cheng, Matthew Blake Greenblatt, Ren Xu

Journal of Clinical Investigation

DOI

2025

The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

Zuoxing Wu, Na Li, Zhengqiong Luo, Zihan Chen, Xuemei He, Fan Shi, Jie Han, Haitao Huang, Baohong Shi, Long Zhang, Yu Li, Junmin Shen, Seoyeon Bok, Jun Sun, Xing Niu, Ke Mo, Pengbin Yin, Lige Leng, Xin Wang, Jie Zhang, Lanfen Chen, Dawang Zhou, Weinan Cheng, Jianmin Huang, Matthew Blake Greenblatt, Ren Xu

Developmental Cell

DOI

2025

Dual Outcomes of Schnurri‐3 Inhibition in Psoriasis: Skeletal Rescue and Dermatological Aggravation

Ying Liu, Li Lin, Xixi Lin, Guixin Yuan, Ren Xu

International Journal of Rheumatic Diseases

DOI

2025

Farrerol alleviates microbiota dysbiosis-associated osteoporosis in IBD by inhibiting PI3K-AKT/MAPK signaling pathways

Ninglu Yin, Yuangang Su, Chaofeng Wang, Jiamin Liang, Tongtong Guo, Jinmin Zhao, Zemin Ling, Ren Xu, Qian Liu

Phytomedicine

DOI

2025

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

Fan Zhang, Yuan Wang, Luyang Zhang, Chunjie Wang, Deping Chen, Haibo Liu, Ren Xu, Cole M. Haynes, Jae‐Hyuck Shim, Xianpeng Ge

eLife

DOI

2024

Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

Na Li, Baohong Shi, Zan Li, Jie Han, Jun Sun, Haitao Huang, Alisha R. Yallowitz, Seoyeon Bok, Shuang Xiao, Zuoxing Wu, Yu Chen, Yan Xu, Tian Qin, Rui Huang, Haiping Zheng, Rong Shen, Lin Meng, Matthew Blake Greenblatt, Ren Xu

Bone Research

DOI

2024

Skeletal stem cells in bone development, homeostasis, and disease

Guixin Yuan, Xixi Lin, Ying Liu, Matthew Blake Greenblatt, Ren Xu

Protein & Cell

DOI

2024

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Zan Li, Xiangchen Zeng, Baohong Shi, Jie Han, Zuoxing Wu, Xiaohui Chen, Long Zhang, Na Li, Matthew Blake Greenblatt, Jianming Huang, Ren Xu

Journal of Orthopaedic Translation

DOI

2024

Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Yu Chen, Long Zhang, Xueqing Shi, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong James Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew Blake Greenblatt, Rongqin Ke, Jianming Huang, Zhe‐Sheng Chen, Ren Xu

Advanced Science

DOI

2024

Author response: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

Fan Zhang, Yuan Wang, Luyang Zhang, Chunjie Wang, Deping Chen, Haibo Liu, Ren Xu, Cole M. Haynes, Jae‐Hyuck Shim, Xianpeng Ge

DOI

2024

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling

Yanhui Zhu, Qingxiang Gao, Jia Zhang, Yu Cheng, Shuzhen Yang, Ren Xu, Jing Yuan, Boris Novakovic, Mihai Gheorghe Netea, Shih‐Chin Cheng

Cell Reports

DOI

2024

Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

Zan Li, Baohong Shi, Na Li, Jun Sun, Xiangchen Zeng, Rui Huang, Seoyeon Bok, Xiaohui Chen, Jie Han, Alisha R. Yallowitz, Shawon Debnath, Michelle Cung, Zheng Ling, Chuan‐Qi Zhong, Yixang Hong, Gang Li, Mascha Koenen, Paul Cohen, Xinhui Su, Hongbin Lü, Matthew Blake Greenblatt, Ren Xu

Nature Communications

DOI

2024

Dental pulp regeneration via dental pulp stem cells conditioned media and curcumin-loaded nanocomposite hydrogel: an in vitro and in vivo study

Bei’er Ma, Ren Xu

Materials Science-Poland

DOI

2024

Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity

Chun‐Lan Xie, Taizong Wu, Yuan Wang, Robert J. Capon, Ren Xu, Xian‐Wen Yang

Organic Letters

DOI

2024

Impacts of immune microenvironment on musculoskeletal health

Ren Xu

Clinical and Translational Discovery

DOI

2024

Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

Long Zhang, Weibin Li, Xiaohui Chen, Dongmin Cao, Siyuan You, Fan Shi, Zhengqiong Luo, Hongyu Li, Xiangchen Zeng, Yabin Song, Na Li, YOSHIE AKIMOTO, Gang Rui, Yu Chen, Zuoxing Wu, Ren Xu

Chemico-Biological Interactions

DOI

2024

Dauricine attenuates ovariectomized-induced bone loss and RANKL-induced osteoclastogenesis via inhibiting ROS-mediated NF-κB and NFATc1 activity

Xixi Lin, Guixin Yuan, Bin Yang, Chun‐Lan Xie, Zhigao Zhou, Ying Liu, Zhijuan Liu, Zuoxing Wu, Yoshie Akimoto, Na Li, Ren Xu, Fangming Song

Phytomedicine

DOI

2024

Innate lymphoid cells: New players in osteoimmunology

Zuoxing Wu, Xixi Lin, Guixin Yuan, Na Li, Ren Xu

European Journal of Immunology

DOI

2023

Deciphering Immune Landscape Remodeling Unravels the Underlying Mechanism for Synchronized Muscle and Bone Aging

Pengbin Yin, Ming Chen, Man Rao, Yuan Lin, Mingming Zhang, Ren Xu, Xueda Hu, Ruijing Chen, Wei Chai, Xiang Huang, Haikuan Yu, Yao Yao, Yali Zhao, Yi Li, Licheng Zhang, Peifu Tang

Advanced Science

DOI

2023

An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway

Alisha R. Yallowitz, Jae‐Hyuck Shim, Ren Xu, Matthew Blake Greenblatt

Bone

DOI

2023

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

Taifeng Zhou, Yu Chen, Zhiheng Liao, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu, Peiqiang Su

Advanced Science

DOI

2023

Skeletal stem-cell therapy: challenge meets opportunity

Weinan Cheng, Jianming Huang, Na Li, Ren Xu

The Lancet

DOI

2023

Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway

Chun-Lan Xie, Yu‐Ting Yue, Jing-Ping Xu, Na Li, Ting Lin, Guang-Rong Ji, Xian‐Wen Yang, Ren Xu

Pharmacological Research

DOI

2023

Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities

Yong Zhang, Chun-Lan Xie, Yuan Wang, Xiwen He, Ming‐Min Xie, You Li, Kai Zhang, Zheng‐Biao Zou, Longhe Yang, Xian‐Wen Yang, Ren Xu

Marine Drugs

DOI

2023

A vertebral skeletal stem cell lineage driving metastasis

Jun Sun, Lingling Hu, Seoyeon Bok, Alisha R. Yallowitz, Michelle Cung, Jason McCormick, Ling J. Zheng, Shawon Debnath, Yuzhe Niu, Adrian Y. Tan, Sarfaraz Lalani, Kyle W. Morse, Daniel J. Shinn, Anthony Pajak, Mohammed Hammad, Vincentius Jeremy Suhardi, Zan Li, Na Li, Lijun Wang, Weiguo Zou, Vivek Mittal, Mathias P. Bostrom, Ren Xu, Sravisht Iyer, Matthew Blake Greenblatt

Nature

DOI

2023

Neotricitrinols A–C, unprecedented citrinin trimers with anti-osteoporosis activity from the deep-sea-derived Penicillium citrinum W23

Zhihui He, Chun‐Lan Xie, Taizong Wu, Yong Zhang, Zheng‐Biao Zou, Ming‐Min Xie, Lin Xu, Robert J. Capon, Ren Xu, Xian‐Wen Yang

Bioorganic Chemistry

DOI

2023

Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis

Han Wang, Jing Liu, Zuoxing Wu, Yangyang Zhao, Man Cao, Baohong Shi, Baolong Chen, Ning Chen, Hao Guo, Na Li, Jian Chen, Ren Xu

Gut Pathogens

DOI

2023

Where it all started

Long Zhang, Na Li, Ren Xu

eLife

DOI

2023

Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

Kazuki Inoue, Yongli Qin, Yuhan Xia, Jie Han, Ruoxi Yuan, Jun Sun, Ren Xu, Jean Xin Jiang, Matthew Blake Greenblatt, Baohong Zhao

eLife

DOI

2023

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

Zuoxing Wu, Xuedong Li, Xiaohui Chen, Xuemei He, Yu Chen, Long Zhang, Zan Li, Mengyu Yang, Guixin Yuan, Baohong Shi, Ning Chen, Na Li, Haotian Feng, Mengyu Zhou, Gang Rui, Feng Xu, Ren Xu

Frontiers in Pharmacology

DOI

2023

Author response: Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

Kazuki Inoue, Yongli Qin, Yuhan Xia, Jie Han, Ruoxi Yuan, Jun You Sun, Ren Xu, Jean Xin Jiang, Matthew Blake Greenblatt, Baohong Zhao

DOI

2022

骨骼干细胞的研究进展

林茜茜，张龙，袁桂鑫，吴佐星，冯昊天，李娜，许韧

《厦门大学学报(自然科学版)》

2022

Tetracyclic Steroids Bearing a Bicyclo[4.4.1] Ring System as Potent Antiosteoporosis Agents from the Deep-Sea-Derived Fungus Rhizopus sp. W23

Zhihui He, Chun‐Lan Xie, Taizong Wu, Yu‐Ting Yue, Chaofeng Wang, Lin Xu, Ming‐Min Xie, Yong Zhang, You‐Jia Hao, Ren Xu, Xian‐Wen Yang

Journal of Natural Products

DOI

2022

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xiaohui Chen, Xu He, Yue Wu, Xiangchen Zeng, Yuting Yueh, Ren Xu, Guangrong Ji

International Journal of Nanomedicine

DOI

2022

Vascular anatomy-based localization of intervertebral discs assisting needle puncture for constructing a mouse model of mechanical injury-induced lumbar intervertebral disc degeneration

Long Zhang, Guicheng Du, Bogang Teng, Xueqing Shi, Xuemei He, Na Li, Yu Chen, Ren Xu

Biochemical and Biophysical Research Communications

DOI

2022

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Jung‐Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin R. Chaugule, Hyonho Chun, Marjolein C. H. van der Meulen, Ren Xu, Matthew Blake Greenblatt, Jae‐Hyuck Shim

eLife

DOI

2022

Author response: Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Jung‐Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin R. Chaugule, Hyonho Chun, Marjolein C. H. van der Meulen, Ren Xu, Matthew Blake Greenblatt, Jae‐Hyuck Shim

DOI

2022

Editorial: Tissue Stem Cells During Trauma: From Basic Biology to Translational Medicine

Guohui Liu, Guozhi Xiao, Jiacan Su, Ren Xu, Zhidao Xia

Frontiers in Cell and Developmental Biology

DOI

2022

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling

Zuoxing Wu, Chen Li, Yu Chen, Qian Liu, Na Li, Xuemei He, Weibin Li, Rong Shen, Li Li, Chenming Wei, Siyuan Shao, Fangsheng Fu, Jiaxin Ding, Xiaochen Sun, Dairong Wang, Guixin Yuan, Yiji Su, Jinmin Zhao, Jiake Xu, Ren Xu, Xin Wen Xu, Xu Feng

Frontiers in Pharmacology

DOI

2022

Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice

Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji

Frontiers in Pharmacology

DOI

2022

New perspective of skeletal stem cells.

Guixin Yuan, Zan Li, Xixi Lin, Na Li, Ren Xu

PubMed

DOI

2021

SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts

Jun Sun, Dong Yeon Shin, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. White, Abdul G. Khan, Ivo C. Lorenz, Jae‐Hyuck Shim, Francis S. Lee, Ren Xu, Matthew Blake Greenblatt

Nature Communications

DOI

2020

Osteoclasts are not a source of SLIT3

Na Li, Kazuki Inoue, Jun Sun, Yingzhen Niu, Sarfaraz Lalani, Alisha R. Yallowitz, Xu Yang, Chao Zhang, Rong Shen, Baohong Zhao, Ren Xu, Matthew Blake Greenblatt

Bone Research

DOI

2020

Bone phenotype in melanocortin 2 receptor-deficient mice

Tsuyoshi Sato, Takanori Iwata, Michihiko Usui, Shoichiro Kokabu, Yasutaka Sugamori, Yuki Takaku, Takashi Kobayashi, Ko Ito, Masahito Matsumoto, Shu Takeda, Ren Xu, Dai Chida

Bone Reports

DOI

2020

Alendronate enhances osseointegration in a murine implant model

K. Vertesich, B. Sosa, Y. Niu, G. Ji, V. Suhardi, K. Turajane, Sehwan Mun, Ren Xu, R. Windhager, Kyung-Hyun Park-Min, M. Greenblatt, M. Bostrom, Xu Yang

Journal of Orthopaedic Research

DOI

2020

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

Jung-Min Kim, Yeon-Suk Yang, K. H. Park, Xianpeng Ge, Ren Xu, Na Li, Minkyung Song, Hyunho Chun, S. Bok, Julia F. Charles, O. Filhol-Cochet, B. Boldyreff, T. Dinter, Paul B. Yu, N. Kon, W. Gu, T. Takarada, M. Greenblatt, Jae-hyuck Shim

Nature Communications

DOI

2019

Vascular endothelial growth factor pathway promotes osseointegration and CD31hiEMCNhi endothelium expansion in a mouse tibial implant model

Gang Ji, Ren Xu, Yingzhen Niu, Nan Li, Lionel B. Ivashkiv, Mathias P. Bostrom, Matthew Blake Greenblatt, Xu Yang

The Bone & Joint Journal

DOI

2018

Targeting skeletal endothelium to ameliorate bone loss

Ren Xu, Alisha R. Yallowitz, A. Qin, Zhu-Hao Wu, Dong-Ye-On Shin, Jung-Min Kim, Shawon Debnath, G. Ji, M. Bostrom, Xu Yang, Chao Zhang, Han Dong, P. Kermani, Sarfaraz Lalani, Na Li, Yi-Fang Liu, Michael G. Poulos, A. Wach, Yi Zhang, Kazuki Inoue, A. Di Lorenzo, Bao-Hong Zhao, J. Butler, Jae-hyuck Shim, L. Glimcher, M. Greenblatt

Nature Medicine

DOI

2018

Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique for anterior cruciate ligament reconstruction: a systematic review of comparative trials

G. Ji, Achao Han, Xue Hao, Na Li, Ren Xu, Fei Wang

Archives of Orthopaedic and Trauma Surgery

DOI

2018

Discovery of a periosteal stem cell mediating intramembranous bone formation

Shawon Debnath, Alisha R. Yallowitz, J. McCormick, Sarfaraz Lalani, Tuo Zhang, Ren Xu, Na Li, Yi-Fang Liu, Yen Yang, Mark Eiseman, Jae-hyuck Shim, M. Hameed, J. Healey, M. Bostrom, D. Landau, M. Greenblatt

Nature

DOI

2018

Bone protection by inhibition of microRNA-182

Kazuki Inoue, Zhonghao Deng, Yufan Chen, Eugenia G. Giannopoulou, Ren Xu, Shiaoching Gong, M. Greenblatt, L. Mangala, G. Lopez-Berestein, D. Kirsch, A. Sood, Liang Zhao, Bao-Hong Zhao

Nature Communications

DOI

2017

c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo

Ren Xu, Chao Zhang, Dong-Ye-On Shin, Jung-Min Kim, Sarfaraz Lalani, Na Li, Yeon-Suk Yang, Yi-Fang Liu, Mark Eiseman, R. Davis, Jae-hyuck Shim, M. Greenblatt

Journal of Bone and Mineral Research

DOI

精选作品

期刊论文

Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Sex hormones and their receptors in osteoarthritis: current research progress

Growth plate cartilage-targeting nanoparticles for pharmacological treatment of hypochondroplasia

Targeting coupling of type H-like vessels and cell fate transition to delay soft tissue aging

Advances in spatial transcriptomics and its application in the musculoskeletal system

Tirzepatide, a dual GLP-1 and GIP receptor agonist, promotes bone loss in obese mice via gut microbial-related metabolites

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway

Identification and function of periosteal skeletal stem cells in skeletal development, homeostasis, and disease

Fibroblast growth factor receptor 3 mutation promotes HSPB6-mediated cuproptosis in hypochondroplasia by impairing chondrocyte autophagy

Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation

The p75 neurotrophin receptor controls the skeletal stem cell niche through sensory innervation

Dual Outcomes of Schnurri‐3 Inhibition in Psoriasis: Skeletal Rescue and Dermatological Aggravation

Farrerol alleviates microbiota dysbiosis-associated osteoporosis in IBD by inhibiting PI3K-AKT/MAPK signaling pathways

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta

Skeletal stem cells in bone development, homeostasis, and disease

Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow

Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics

Author response: The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

Persistent bone marrow hemozoin accumulation confers a survival advantage against bacterial infection via cell-intrinsic Myd88 signaling

Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

Dental pulp regeneration via dental pulp stem cells conditioned media and curcumin-loaded nanocomposite hydrogel: an in vitro and in vivo study

Genome Mining of a Deep-Sea-Derived Penicillium allii-sativi Revealed Polyketide-Terpenoid Hybrids with Antiosteoporosis Activity

Impacts of immune microenvironment on musculoskeletal health

Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling

Dauricine attenuates ovariectomized-induced bone loss and RANKL-induced osteoclastogenesis via inhibiting ROS-mediated NF-κB and NFATc1 activity

Innate lymphoid cells: New players in osteoimmunology

Deciphering Immune Landscape Remodeling Unravels the Underlying Mechanism for Synchronized Muscle and Bone Aging

An angiogenic approach to osteoanabolic therapy targeting the SHN3-SLIT3 pathway

Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution

Skeletal stem-cell therapy: challenge meets opportunity

Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway

Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities

A vertebral skeletal stem cell lineage driving metastasis

Neotricitrinols A–C, unprecedented citrinin trimers with anti-osteoporosis activity from the deep-sea-derived Penicillium citrinum W23

Gut microbiota signatures and fecal metabolites in postmenopausal women with osteoporosis

Where it all started

Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

Author response: Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass

骨骼干细胞的研究进展

Tetracyclic Steroids Bearing a Bicyclo[4.4.1] Ring System as Potent Antiosteoporosis Agents from the Deep-Sea-Derived Fungus Rhizopus sp. W23

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

Vascular anatomy-based localization of intervertebral discs assisting needle puncture for constructing a mouse model of mechanical injury-induced lumbar intervertebral disc degeneration

Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Author response: Biphasic regulation of osteoblast development via the ERK MAPK–mTOR pathway

Editorial: Tissue Stem Cells During Trauma: From Basic Biology to Translational Medicine

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling

Mogrol Attenuates Osteoclast Formation and Bone Resorption by Inhibiting the TRAF6/MAPK/NF-κB Signaling Pathway In vitro and Protects Against Osteoporosis in Postmenopausal Mice

New perspective of skeletal stem cells.

SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts

Osteoclasts are not a source of SLIT3

Bone phenotype in melanocortin 2 receptor-deficient mice

Alendronate enhances osseointegration in a murine implant model

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

Vascular endothelial growth factor pathway promotes osseointegration and CD31hiEMCNhi endothelium expansion in a mouse tibial implant model

Targeting skeletal endothelium to ameliorate bone loss

Better rotational control but similar outcomes with the outside-in versus the transtibial drilling technique for anterior cruciate ligament reconstruction: a systematic review of comparative trials

Discovery of a periosteal stem cell mediating intramembranous bone formation

Bone protection by inhibition of microRNA-182

c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo

预印本

Reprogramming of Myelopoiesis by Malaria-induced Hemozoin Accumulation

Identification and characterization of human skeletal stem cell-like cells derived from infrapatellar fat pad

研究方向