百晓学者学者目录

张志刚

副教授、教授、讲师，湖北中医药大学

精选作品

期刊论文

2026

基于网络药理学和分子对接技术分析紫珠叶洗剂促进创面愈合的作用机制

刘泽睿，邬裕，劳傲天，欧阳帅，张志刚，卢国樑

《新中医》

2026

基于山药多糖对沙棘黄酮保护作用的沙棘山药胶囊工艺研究

张志刚，姚玉军，代利霞，邢国良，武世奎

《中国现代应用药学》

DOI

2026

IL-22在放射性肠损伤中的研究进展

朱雷，张志刚，郭利，王建钰，刘军叶

《生命科学》

2026

中医如何预防脑卒中

张志刚，张元明

《医食参考》

2026

Enzymatic properties of Achatina fulica enzyme GH5–2339 and its application in the preparation of Bletilla striata oligosaccharides

Jiaojiao Huang, Shengtao Ji, Hongwei Lei, Lei Xiong, Baifei Hu, Haiyan Gao, Zhigang Zhang, Hongtao Liu

International Journal of Biological Macromolecules

DOI

2025

基于转录组学与网络药理学探讨四妙散治疗膝骨关节炎的作用机制

伍搏宇，杨雷，张志刚，熊辉，王海彬，卢国樑

《中药新药与临床药理》

2025

基于网络药理学及体内实验研究八味降脂汤治疗高脂血症的作用机制

廖凯，李秀萍，李丹彤，唐润甜，刁方炜，张志刚

《世界中医药》

2025

Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling

Sang Lin, Sheng Tan, Yonglin Peng, Aziguli Tulamaiti, Wen-Fei Du, Keshuo Ding, Chang-Yu Chen, Jun Wu, Hua Li, Wei Xu, Jie-Lin Sun, Xue-Li Zhang, Zhigang Zhang, Xiao-Dong Zhao

Nature Communications

DOI

2025

5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis

Kaiyuan Liu, Ying-Chao Zhang, Genyu Du, Xinyu Chen, Lingling Xiao, Lu-Yao Jiang, Na Jing, Penghui Xu, Chaoxian Zhao, Yiyun Liu, Hui-Fang Zhao, Yu-Jiao Sun, Jin-Ming Wang, Chaping Cheng, Deng Wang, Jia-Hua Pan, Wei Xue, Pengcheng Zhang, Zhigang Zhang, Wei-Qiang Gao, Shu-Heng Jiang, Kai Zhang, Helen He Zhu

Journal of Clinical Investigation

DOI

2025

ENO1 promotes PDAC progression by inhibiting CD8+ T cell infiltration through upregulating PD-L1 expression via HIF-1α signaling

Aziguli Tulamaiti, S. Xiao, Yan Yang, Musitaba Mutailifu, Xia-Qing Li, Shi-Qi Yin, Hong-Tai Ma, Hong-Fei Yao, Linli Yao, Lipeng Hu, Jun Li, Shuheng Jiang, Zhigang Zhang, Yanmmiao Huo, Dong-Xue Li, Xue-Li Zhang

Translational Oncology

DOI

2025

Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR

Zheng Wu, Qing Ye, Shan Zhang, Lipeng Hu, Xiao-Qi Wang, Linli Yao, Lei Zhu, S. Xiao, Zonghao Duan, Xue-Li Zhang, Shu-Heng Jiang, Zhigang Zhang, Dejun Liu, Dong-Xue Li, Xiao-Mei Yang

Clinical and Translational Medicine

DOI

2025

Dihydromyricetin Improves Ulcerative Colitis by Suppressing NLRP3 Inflammasome Activation Caused by Dysbiosis of Gut Microbiota

Jun Chen, Shengchen Ding, Huabing Yang, Yi Dai, Zhigang Zhang, Tianxiang Zhu, Lu Cao, Baifei Hu, Hongtao Liu

Journal of Inflammation Research

DOI

2025

Characterization of a Cold-Active Xylanase from Paenibacillus sp. XP01, and Its Application in Hydrolyzing Alkali-Pretreated Corncob Residues

Yu Wei Gao, Tianxiang Zhu, Zhigang Zhang, Haiming Hu, Qiqi Wang, Hongtao Liu, Lei Xiong

Journal of Agricultural and Food Chemistry

DOI

2025

Structural characterization and probiotic activity of Chenpi polysaccharides prepared by fermentation with Bacillus licheniformis

Yangjincan Liu, Yangjincan Liu, Haiming Hu, Haiming Hu, Huabing Yang, Lei Xiong, Junping Zheng, Tianxiang Zhu, Zhigang Zhang, Hongtao Liu

Food Bioscience

DOI

2025

Structure characteristics and fermentation properties of konjac oligosaccharides from konjac peel prepared by one-step fermentation with Bacillus Licheniformis BJ2022

Qiqi Wang, Songlin Liu, Tianxiang Zhu, Baifei Hu, Yuqing Huang, Yu Wei Gao, Lei Xiong, Lu Cao, Zhigang Zhang, Hongtao Liu

Food Chemistry

DOI

2025

A novel salt-adapted bifunctional glucanase/mannanase from Klebsiella pneumoniae and its application in oligosaccharide production

Y.L. Li, Zhigang Zhang, Lei Xiong, Junping Zheng, Tianxiang Zhu, Jingjing Li, Aizhen Lin, Hongtao Liu

International Journal of Biological Macromolecules

DOI

2025

Functional Characterization of a Highly Efficient Endoglucanase from Bacillus licheniformis BJ2022 and Its Application in the Preparation of Low-Molecular-Weight Konjac Glucomannan

Tianxiang Zhu, Songlin Liu, Yu Wei Gao, Xiongjie Sun, Haiming Hu, Zhigang Zhang, Wenwen Zhang, Lei Xiong, Hongtao Liu

Journal of Agricultural and Food Chemistry

DOI

2024

A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity.

Xu Wang, Sheng-Qiao Fu, Xiao Yuan, Feng Yu, Qian Ji, Hao-Zhong Tang, Rong-Kun Li, Shan Huang, Pei-Qi Huang, Wei-Ting Qin, Hao Zuo, Chang Du, Linli Yao, Hui Li, Jun Li, Dong-Xue Li, Yan Yang, S. Xiao, Aziguli Tulamaiti, Xue-Feng Wang, Chun-hua Dai, Xu Zhang, Shuheng Jiang, Lipeng Hu, Xue-Li Zhang, Zhigang Zhang

Molecules and Cells

DOI

2024

Corrigendum to "Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC." [Biochem. Biophys. Res. Commun. 499 (3) (2018 May 15) 584-593].

Xiao-Yan Cao, Xiao-Xin Zhang, Min-Wei Yang, Lipeng Hu, Shuheng Jiang, Guang-Ang Tian, Li-Li Zhu, Qing Li, Yong-Wei Sun, Zhigang Zhang

Biochemical and Biophysical Research Communications - BBRC

DOI

2024

Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma

Linli Yao, Wei-Ting Qin, Lipeng Hu, Tiezhu Shi, Jian-Yu Yang, Qing Li, Hui-Zhen Nie, Jun Li, Xu Wang, Lei Zhu, De-Jun Liu, Yan-Li Zhang, Shu-Heng Jiang, Zhigang Zhang, Xiao-Mei Yang, Dong-Xue Li, Xue-Li Zhang

Cancer Communications

DOI

2024

A silver auto-catalyzed plasmonic enzyme-linked immunosorbent assay for colorimetric and fluorescent detection of neutrophil gelatinase associated lipocalin (NGAL)

Yu Liu, Yawen Liu, Fangfang Wang, Zhigang Zhang, Haiming Hu, Lei Xiong, Junping Zheng, Hongtao Liu

Microchemical Journal

DOI

2023

基于复方网络药理学和分子对接技术探究吴门通络解毒汤治疗强直性脊柱炎的作用机制

张擎天，张志刚，沈晓峰，陈华，段星星，徐波，陈紫轩，李宇卫

《中国处方药》

2023

Nucleolar HEATR1 upregulated by mTORC1 signaling promotes hepatocellular carcinoma growth by dominating ribosome biogenesis and proteome homeostasis.

Xiao-Mei Yang, Xiao-Qi Wang, Lipeng Hu, M. Feng, Yao-Qi Zhou, Dong-Xue Li, Jun Li, Xiaomeng Miao, Yan-Li Zhang, Linli Yao, Hui-Zhen Nie, Shan Huang, Q. Xia, Xue-Li Zhang, Shuheng Jiang, Zhigang Zhang

Gastroenterology

DOI

2023

CCBE1 promotes mitochondrial fusion by inhibiting the TGFβ-DRP1 axis to prevent the progression of hepatocellular carcinoma.

Guang-Ang Tian, Wen-ting Xu, Xue-Li Zhang, Yao-Qi Zhou, Yue Sun, Lipeng Hu, Shuheng Jiang, Hui-Zhen Nie, Zhigang Zhang, Lei Zhu, Jun Li, Xiao-Mei Yang, Linli Yao

Matrix Biology

DOI

2023

FADS1-arachidonic acid axis enhances arachidonic acid metabolism by altering intestinal microecology in colorectal cancer

Chun-Jie Xu, Lei Gu, Lipeng Hu, Chun-hui Jiang, Qing Li, Long-ci Sun, Hong Zhou, Ye Liu, Hanbing Xue, Jun Li, Zhigang Zhang, Xue-Li Zhang, Qing Xu

Nature Communications

DOI

2023

METTL3 suppresses pancreatic ductal adenocarcinoma progression through activating endogenous dsRNA-induced anti-tumor immunity

Li-Li Zhu, Botai Li, Rong-Kun Li, Lipeng Hu, Yan-Li Zhang, Zhigang Zhang, Shuheng Jiang, Xue-Li Zhang

Cellular Oncology

DOI

2023

Harnessing 3D in vitro systems to model immune responses to solid tumours: a step towards improving and creating personalized immunotherapies

Zhen-Zhen Zhou, Y. Pang, J. Ji, Jianyu He, Tiankun Liu, Liliang Ouyang, Wen Zhang, Xue-Li Zhang, Zhigang Zhang, Kaitai Zhang, Wei Sun

Nature reviews. Immunology

DOI

2023

The SLITRK4-CNPY3 axis promotes liver metastasis of gastric cancer by enhancing the endocytosis and recycling of TrkB in tumour cells

Yao-Qi Zhou, Tian-Shang Bao, Jia-Xuan Xie, Linli Yao, Sitao Yu, Qing Li, Pei-Qi Huang, Wan-Bang Zhou, Yang-Yang Wang, Su-Yuan Chen, Xiao-Qi Wang, Xue-Li Zhang, Shuheng Jiang, Shuang-Qin Yi, Zhigang Zhang, Mingze Ma, Lipeng Hu, Jia Xu, Jun Li

Cellular Oncology

DOI

2023

Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner

Shan Huang, Naiqi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Linli Yao, K. Sundquist, J. Sundquist, Shuheng Jiang, Xin Xing, Lipeng Hu, Zhigang Zhang, J. Ji, Xue-Li Zhang

Cellular Oncology

DOI

2023

Transglutaminases are oncogenic biomarkers in human cancers and therapeutic targeting of TGM2 blocks chemoresistance and macrophage infiltration in pancreatic cancer

Shan Zhang, Hong Yao, Haiyang Li, Tong Su, Shuheng Jiang, Hao Wang, Zhigang Zhang, Fangyuan Dong, Qin Yang, Xiao-Mei Yang

Cellular Oncology

DOI

2023

Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma

Qing Li, Xiao-Xin Zhang, Lipeng Hu, B-L Ni, Dong-Xue Li, Xu Wang, Shuheng Jiang, Hui Li, Min-Wei Yang, Yong-Sheng Jiang, Chun-Jie Xu, Xue-Li Zhang, Yan-Li Zhang, Pei-Qi Huang, Qin Yang, Yang Zhou, Jian-ren Gu, G. Xiao, Yong-Wei Sun, Jun Li, Zhigang Zhang

Nature Communications

DOI

2023

Structural characterization and prebiotic activity of Bletilla striata polysaccharide prepared by one-step fermentation with Bacillus Licheniformis BJ2022

Qiqi Wang, Haiming Hu, Lei Xiong, Xuexia Jin, Tianxiang Zhu, Xiongjie Sun, Zhigang Zhang, Hongtao Liu

International Journal of Biological Macromolecules

DOI

2023

Suppressive effect of Tripterygium hypoglaucum (Levl.) Hutch extract on rheumatoid arthritis in mice by modulating inflammasome and bile acid metabolism

Junping Zheng, Jianghui Hu, Yong Yang, Lei Xiong, Huabing Yang, Zhigang Zhang, Nan Jiang, Hongtao Liu

Biomedicine & Pharmacotherapy

DOI

2023

In vitro digestion and human gut microbiota fermentation of Bletilla striata polysaccharides and oligosaccharides

Qiqi Wang, Huimin Chen, Mingzhu Yin, Xue Cheng, Hui Xia, Haiming Hu, Junping Zheng, Zhigang Zhang, Hongtao Liu

Frontiers in Cellular and Infection Microbiology

DOI

2023

Lactobacillus acidophilus‐Fermented Jujube Juice Ameliorates Chronic Liver Injury in Mice via Inhibiting Apoptosis and Improving the Intestinal Microecology

Yu Zhang, Haitian Fang, Tong Wang, Zhigang Zhang, Tianxiang Zhu, Lei Xiong, Haiming Hu, Hongtao Liu

Molecular Nutrition & Food Research

DOI

2023

Berberine improves DSS-induced colitis in mice by modulating the fecal-bacteria-related bile acid metabolism

Xiongjie Sun, Yu Zhang, Gang Cheng, Tianxiang Zhu, Zhigang Zhang, Lei Xiong, Haiming Hu, Hongtao Liu

Biomedicine & Pharmacotherapy

DOI

2023

Tannic Acid Suppresses HBV Replication via the Regulation of NF-κB, MAPKs, and Autophagy in HepG2.2.15 Cells

Xuefeng Wang, Baifei Hu, Haiming Hu, Shuhan Zhou, Mingzhu Yin, Xue Cheng, Zhigang Zhang, Hongtao Liu

Journal of Agricultural and Food Chemistry

DOI

2023

The SUMOylation of Human Cytomegalovirus Capsid Assembly Protein Precursor (UL80.5) Affects Its Interaction with Major Capsid Protein (UL86) and Viral Replication

Zhigang Zhang, Sisi Xia, Zhigang Wang, Nina Yin, Jun Chen, Luyao Shao

Viruses

DOI

2023

HEMIN ATTENUATED LPS-INDUCED ACUTE LUNG INJURY IN MICE VIA PROTECTING PULMONARY EPITHELIAL BARRIER AND REGULATING HO-1/NLRP3-MEDIATED PYROPTOSIS

Xue Cheng, Mingzhu Yin, Xiongjie Sun, Zhigang Zhang, Xiaowei Yao, Hongtao Liu, Hui Xia

Shock

DOI

2022

葛氏正骨手法结合克氏针撬拨复位内固定治疗SandersⅡ、Ⅲ型跟骨骨折50例

朱宇，张志刚，陈金飞，段星星，俞振翰

《湖南中医杂志》

2022

基于体外发酵模型的连朴饮及黄连-厚朴药对对人体肠道菌群影响的研究

汪琪琪，毛宁峰，张志刚，吕露，殷明珠

《时珍国医国药》

2022

柴胡疏肝汤加减治疗脑血管病引发的抑郁症的临床效果

薛立伏，冯莹莹，孙维颖，张志刚，张峥

《中西医结合心血管病电子杂志》

2022

The genomic, transcriptomic, and immunological profiles of perineural invasion in pancreatic ductal adenocarcinoma

Shuheng Jiang, Rong-kun Li, De-Jun Liu, Jun Xue, Min-Hao Yu, Shan Zhang, Li-min Liu, Jun-Feng Zhang, R. Hua, Yong-Wei Sun, Xu Wang, Qin Yang, Zhigang Zhang

Science China Life Sciences

DOI

2022

A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma

Yi-Fan Zhang, Qing Li, Pei-Qi Huang, Tong Su, Shuheng Jiang, Lipeng Hu, Xue-Li Zhang, Yue Sun, H. Pan, Xiao-Mei Yang, Jun Li, Yan-Zhi Gai, Lei Zhu, Linli Yao, Dong-Xue Li, Yong-Wei Sun, Zhigang Zhang, De-Jun Liu, Yan-Li Zhang, Hui-Zhen Nie

Oncogene

DOI

2022

Emerging experimental models for assessing perineural invasion in human cancers.

Shuheng Jiang, Shan Zhang, Hao Wang, Jun-li Xue, Zhigang Zhang

Cancer Letters

DOI

2022

S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3‐mediated programmed death‐ligand 1 expression in colorectal cancer

Hyeyoung Min, Jaebeom Cho, Jeong Yeon Sim, Hye-Jin Boo, Ji-Sun Lee, Seon-Boon Lee, Young-Jin Lee, S. Kim, Kyu-Pyo Kim, In-Ja Park, Seung-Mo Hong, Xue-Li Zhang, Zhigang Zhang, R. Park, Ho-Yyoung Lee

Clinical and Translational Medicine

DOI

2022

Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptake

Chun-Jie Xu, Lei Gu, Manzila Kuerbanjiang, Chun-hui Jiang, Lipeng Hu, Ye Liu, Hanbing Xue, Jun Li, Zhigang Zhang, Qing Xu

Oncogene

DOI

2022

Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells

Xuefeng Wang, Haiming Hu, Baifei Hu, Hui Xia, Xue Cheng, Junping Zheng, Zhigang Zhang, Hongtao Liu

Molecular Biology Reports

DOI

2022

Cloning and expression of recombinant human superoxide dismutase 1 (hSOD1) in Bacillus subtilis 1012

Mingzhu Yin, Nian Wang, Qiqi Wang, Hui Xia, Xue Cheng, Haiming Hu, Zhigang Zhang, Hongtao Liu

Biotechnology Letters

DOI

2022

Bletilla striata Oligosaccharides Improve Ulcerative Colitis by Regulating Gut Microbiota and Intestinal Metabolites in Dextran Sulfate Sodium-Induced Mice

Tianxiang Zhu, Baifei Hu, Cheng Ye, Haiming Hu, Mingzhu Yin, Zhigang Zhang, Shuiqing Li, Yanju Liu, Hongtao Liu

Frontiers in Pharmacology

DOI

2022

Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis

Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu

Frontiers in Pharmacology

DOI

2021

基于MSU分型观察中药联合孔镜治疗腰椎间盘突出症的临床疗效

段星星，李宇卫，张志刚，沈晓峰，李红卫

《湖南中医杂志》

DOI

2021

银杏叶提取物通过Akt/mTOR通路抑制难治性癫痫大鼠海马组织细胞凋亡研究

梁金斌，张志刚，林黎

《新中医》

DOI

2021

经皮撬拨复位克氏针内固定与跗骨窦入路钢板内固定治疗Sanders Ⅱ型跟骨骨折的临床研究

段星星，张志刚，李宇卫，陈金飞，刘锦涛

《浙江中西医结合杂志》

2021

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Xu Wang, Lipeng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Linli Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shuheng Jiang, Xue-Li Zhang, Zhigang Zhang

Nature Communications

DOI

2021

Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics

Lipeng Hu, Kai-Xia Zhou, Y. Huo, De-Jun Liu, Qing Li, Min-Wei Yang, Pei-Qi Huang, Chun-Jie Xu, Guang-Ang Tian, Linli Yao, Xue-Li Zhang, Ya-Hui Wang, Jun Li, Zhigang Zhang, Shuheng Jiang, Xin Xing, Xu Wang, Wei-Ting Qin, Qin Yang

Oncogenesis

DOI

2021

Deciphering the genomic and lncRNA landscapes of aerobic glycolysis identifies potential therapeutic targets in pancreatic cancer

Li-Li Zhu, Zheng Wu, Rong-kun Li, Xin Xing, Yong-Sheng Jiang, Jun Li, Ya-Hui Wang, Lipeng Hu, Xu Wang, Wei-Ting Qin, Yong-Wei Sun, Zhigang Zhang, Qin Yang, Shuheng Jiang

International Journal on Biological Sciences

DOI

2021

Increased Nuclear Transporter KPNA2 Contributes to Tumor Immune Evasion by Enhancing PD-L1 Expression in PDAC

Kai-Xia Zhou, Shan Huang, Lipeng Hu, Xue-Li Zhang, Wei-Ting Qin, Yan-Li Zhang, Linli Yao, Yan-qiu Yu, Yao-Qi Zhou, Lei Zhu, J. Ji, Zhigang Zhang

Journal of Immunological Research

DOI

2021

A positive feedback between HIF1α and lysyl oxidase-like 2 dictates the Warburg Effect in Pancreatic Cancer

Rong-kun Li, Ya-Hui Wang, Li-Li Zhu, Xiaoxin Zhang, De-Jun Liu, Qing Li, B-L Ni, Lipeng Hu, Zhigang Zhang, Yan-Li Zhang, Xu Wang, Shuheng Jiang

DOI

2021

The physiology, pathology and potential therapeutic application of serotonylation.

Shuheng Jiang, Ya-Hui Wang, Lipeng Hu, Xu Wang, Jun Li, Xue-Li Zhang, Zhigang Zhang

Journal of Cell Science

DOI

2021

The short isoform of PRLR suppresses the pentose phosphate pathway and nucleotide synthesis through the NEK9-Hippo axis in pancreatic cancer

Hui-Zhen Nie, Pei-Qi Huang, Shuheng Jiang, Qin Yang, Lipeng Hu, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing Li, Yi-Fan Zhang, Lei Zhu, Yan-Li Zhang, Yan-qiu Yu, G. Xiao, Yong-Wei Sun, J. Ji, Zhigang Zhang

Theranostics

DOI

2021

CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-β receptors in colorectal cancer

Xue-Li Zhang, Lipeng Hu, Qin Yang, Wei-Ting Qin, Xu Wang, Chun-Jie Xu, Guang-Ang Tian, Xiao-Mei Yang, Linli Yao, Lei Zhu, Hui-Zhen Nie, Qing Li, Qing Xu, Zhigang Zhang, Yan-Li Zhang, Jun Li, Ya-Hui Wang, Shuheng Jiang

Oncogene

DOI

2021

Nuclear-translocation of ACLY induced by obesity-related factors enhances pyrimidine metabolism through regulating histone acetylation in endometrial cancer.

M. Dai, Bikang Yang, Jing Chen, Fei Liu, Yan-Jie Zhou, Yang Zhou, Qin-Yang Xu, Shuheng Jiang, Shu-Jie Zhao, Xinchun Li, Xuan Zhou, Qin Yang, Jun Li, Ya-Hui Wang, Zhigang Zhang, Yincheng Teng

Cancer Letters

DOI

2021

Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Rong-Kun Li, Heng-Chao Li, Li-Li Zhu, Xiaoxin Zhang, De-Jun Liu, Qing Li, B-L Ni, Lipeng Hu, Zhigang Zhang, Yan-Li Zhang, Xu Wang, Shuheng Jiang

Cell Death and Disease

DOI

2021

Integrated genomic and transcriptomic analysis reveals unique characteristics of hepatic metastases and pro-metastatic role of complement C1q in pancreatic ductal adenocarcinoma

Jian-Yu Yang, Ping Lin, Min-Wei Yang, Wei Liu, Xue-Liang Fu, De-Jun Liu, Ling-Ye Tao, Y. Huo, Jun-Feng Zhang, R. Hua, Zhigang Zhang, Yi-Xue Li, Li-Wei Wang, J. Xue, Hong Li, Yong-Wei Sun

Genome Biology

DOI

2021

Spatiotemporal quantification of metastatic tumour cell growth and distribution in lymph nodes by whole-mount tissue 3D imaging

Jun Li, Chun-Jie Xu, Guang-Ang Tian, Qing Li, Dong-Xue Li, Fang Yan, Yao-Yao Zhou, Pei-Qi Huang, Jia-Xuan Xie, Xu Wang, Shuheng Jiang, Ya-Hui Wang, Jian Song, Xue-Li Zhang, Shuang-Qin Yi, Lipeng Hu, Qing-qing Xu, Xiao-Wei Li, Zhigang Zhang

International Journal on Biological Sciences

DOI

2021

TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.

Bikang Yang, Jing Chen, Xiao Li, Xue-Li Zhang, Lipeng Hu, Shuheng Jiang, Zhigang Zhang, Yincheng Teng

Cancer Letters

DOI

2021

N-acetyl-chitooligosaccharide attenuates inflammatory responses by suppression of NF-κB signaling, MAPK and NLRP3 inflammasome in macrophages

Haiming Hu, Hui Xia, Xiaojuan Zou, Xinyu Li, Zhigang Zhang, Xiaowei Yao, Mingzhu Yin, Daizhi Tian, Hongtao Liu

Journal of Functional Foods

DOI

2020

益气逐瘀方治疗早期脊髓型颈椎病临床研究

马智佳，姜宏，俞鹏飞，刘锦涛，张志刚，李红卫

《新中医》

DOI

2020

探讨补阳还五汤加减配合针刺回阳九针穴联合康复训练在治疗中风后遗症中的作用

顾广富，李广振，张志刚

《中西医结合心血管病电子杂志》

2020

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

Jin-Tao Li, M. Yin, Di Wang, Jian Wang, Ming-Zhu Lei, Ye Zhang, Ying Liu, Lei Zhang, Shao-Wu Zou, Lipeng Hu, Zhigang Zhang, Yi-Ping Wang, Wenyan Wen, Hao-Jie Lu, Zheng-Ju Chen, Dan Su, Qun-Ying Lei

Nature Cell Biology

DOI

2020

MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Guang-Ang Tian, Chun-Jie Xu, Kai-Xia Zhou, Zhigang Zhang, Jian-ren Gu, Xue-Li Zhang, Ya-Hui Wang

Journal of Immunological Research

DOI

2020

Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2

Shuheng Jiang, Fangyuan Dong, Lin-Tai Da, Xiao-Mei Yang, Xiao-Xue Wang, J. Weng, Lei Feng, Li-Li Zhu, Yan-Li Zhang, Zhigang Zhang, Yong-Wei Sun, Jun Li, Min-Juan Xu

The FASEB Journal

DOI

2020

Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels

Shuheng Jiang, Xiaoxin Zhang, Lipeng Hu, Xu Wang, Qing Li, Xue-Li Zhang, Jun Li, Jian-ren Gu, Zhigang Zhang

Frontiers in Cell and Developmental Biology

DOI

2020

Serotonin-RhoA/ROCK axis promotes acinar-to-ductal metaplasia in caerulein-induced chronic pancreatitis.

Xu-Feng Tao, Qing Chen, Ning Li, Hong Xiang, Yue Pan, Yueyang Qu, D. Shang, V. L. Go, J. Xue, Yong-Wei Sun, Zhigang Zhang, Junchao Guo, G. Xiao

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2020

Prognostic and predictive value of a five-molecule panel in resected pancreatic ductal adenocarcinoma: A multicentre study

Junchao Guo, Peng Zhang, Li Zhou, L. You, Qiao Liu, Zhigang Zhang, Bei Sun, Zhi-Yong Liang, Junliang Lu, D. Yuan, Ai-Di Tan, Jian Sun, Q. Liao, M. Dai, G. Xiao, Shao Li, Tai-Ping Zhang

EBioMedicine

DOI

2020

Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer

Qing Wang, Meng-Ge Li, Y. Gan, Shuheng Jiang, J. Qiao, Wei Zhang, Yingchao Fan, Yu-Ling Shen, Yan-Fang Song, Zi-Hong Meng, M. Yao, Jianren Gu, Zhigang Zhang, H. Tu

Theranostics

DOI

2020

Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

Yang Zhou, Fei Liu, Qin-Yang Xu, Bikang Yang, Xiao Li, Shuheng Jiang, Lipeng Hu, Xue-Li Zhang, Li-Li Zhu, Qing Li, Xiaolu Zhu, Hong-Fang Shao, M. Dai, Yifei Shen, B-L Ni, Shuai Wang, Zhigang Zhang, Yincheng Teng

Oncogene

DOI

2020

Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing

Qin Yang, Can-can Zhang, Yuan Ren, H. Yi, T. Luo, Fangliang Xing, Xuefeng Bai, L. Cui, Lin-Yan Zhu, J. Ouyang, Pengcheng Jiang, Weirong Fan, Jianping Qiu, Fengmian Wang, Xin Xing, Zhigang Zhang, Xue-Li Zhang, Rong Zhang

Neoplasia

DOI

2020

MELK promotes Endometrial carcinoma progression via activating mTOR signaling pathway

Qin-Yang Xu, Qiu-Lin Ge, Yang Zhou, Bikang Yang, Qin Yang, Shuheng Jiang, Rong-Zhen Jiang, Zhi-Hong Ai, Zhigang Zhang, Yincheng Teng

EBioMedicine

DOI

2020

TIMELESS regulates sphingolipid metabolism and tumor cell growth through Sp1/ACER2/S1P axis in ER-positive breast cancer

Shan Zhang, Pei-Qi Huang, Huijuan Dai, Qing Li, Lipeng Hu, Jing Peng, Shuheng Jiang, Yaqian Xu, Zi-Ping Wu, Hui-Zhen Nie, Zhigang Zhang, W. Yin, Xue-Li Zhang, Jinsong Lu

Cell Death and Disease

DOI

2020

Cadherin 13 Inhibits Pancreatic Cancer Progression and Epithelial-mesenchymal Transition by Wnt/β-Catenin Signaling

Dengfei Xu, Hui Yuan, Zi-Hong Meng, Chun-Mei Yang, Zefang Li, Meng-Ge Li, Zhigang Zhang, Y. Gan, H. Tu

Journal of Cancer

DOI

2020

STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells

Xiangyu Wang, Fengmian Wang, Zhigang Zhang, Xiao-Mei Yang, Rong Zhang, Jian Song

Journal of Immunological Research

DOI

2020

Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma

Min-Wei Yang, Ling-Ye Tao, Yong-Sheng Jiang, Jian-Yu Yang, Y. Huo, De-Jun Liu, Jiao Li, Xue-Liang Fu, Rui-Zhe He, Chao-Yi Lin, Wei Liu, Jun-Feng Zhang, R. Hua, Qing Li, Shuheng Jiang, Lipeng Hu, Guang-Ang Tian, Xiao-Xin Zhang, Ning-Ning Niu, P. Lu, Juan-Juan Shi, G. Xiao, Li-wei Wang, J. Xue, Zhigang Zhang, Yong-Wei Sun

Cancer Research

DOI

2020

A review: Roles of carbohydrates in human diseases through regulation of imbalanced intestinal microbiota

Xue Cheng, Junping Zheng, Aizhen Lin, Hui Xia, Zhigang Zhang, Qinghua Gao, Wenliang Lv, Hongtao Liu

Journal of Functional Foods

DOI

2020

Bletilla striata oligosaccharides improve metabolic syndrome through modulation of gut microbiota and intestinal metabolites in high fat diet-fed mice

Baifei Hu, Cheng Ye, Elaine Lai‐Han Leung, Lin Zhu, Haiming Hu, Zhigang Zhang, Junping Zheng, Hongtao Liu

Pharmacological Research

DOI

2019

四川不同产地淫羊藿补肾壮阳作用研究

龚明峰，张志刚

《湖北中医杂志》

2019

血塞通联合西药治疗急性心肌梗死急诊PCI术后疗效观察及对心功能和炎症因子的影响

张志刚

《新中医》

DOI

2019

Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

Ning-Ning Niu, P. Lu, Yan-Lin Yang, Rui-Zhe He, Li Zhang, Juan-Juan Shi, Jinghua Wu, Min-Wei Yang, Zhigang Zhang, Li-wei Wang, Wei-Qiang Gao, Aida Habtezion, G. Xiao, Yong-Wei Sun, Li Li, J. Xue

Gut

DOI

2019

Clinical significance of programmed death 1/programmed death ligand 1 pathway in gastric neuroendocrine carcinomas

Min-Wei Yang, Xue-Liang Fu, Yong-Sheng Jiang, Xiao-jing Chen, Ling-Ye Tao, Jian-Yu Yang, Y. Huo, Wei Liu, Jun-Feng Zhang, Pei-Feng Liu, Qiang Liu, R. Hua, Zhigang Zhang, Yong-Wei Sun, De-Jun Liu

World Journal of Gastroenterology

DOI

2019

CTHRC1 promotes M2-like macrophage recruitment and myometrial invasion in endometrial carcinoma by integrin-Akt signaling pathway

Lu-Ying Li, Ke Yin, Y. Bai, Zhigang Zhang, W. Di, Shu Zhang

Clinical and Experimental Metastasis

DOI

2019

DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Jian-Yu Yang, Yong-Sheng Jiang, Rui-Zhe He, Wei Liu, Min-Wei Yang, Ling-Ye Tao, Xue-Liang Fu, Yang Shen, Jiao Li, De-Jun Liu, Y. Huo, Jun-Feng Zhang, R. Hua, Zhigang Zhang, Yong-Wei Sun

Journal of Immunological Research

DOI

2019

Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

Rong-Kun Li, Ya-Hui Wang, Xiaoxin Zhang, M. Feng, Jun Ma, Jun Li, Xiaomei Yang, F. Fang, Q. Xia, Zhigang Zhang, Mingyi Shang, Shuheng Jiang

Molecular Cancer

DOI

2019

The Diverse Function of PD-1/PD-L Pathway Beyond Cancer

W. Qin, Lipeng Hu, Xue-Li Zhang, Shuheng Jiang, Jun Li, Zhigang Zhang, Xu Wang

Frontiers in Immunology

DOI

2019

Targeting the tumor microenvironment for pancreatic ductal adenocarcinoma therapy.

Yi-Fan Zhang, Shuheng Jiang, Lipeng Hu, Pei-Qi Huang, Xu Wang, Jun Li, Xue-Li Zhang, Hui-Zhen Nie, Zhigang Zhang

Chinese Clinical Oncology

DOI

2019

Alternative transcription start site selection in ACSS2 controls its nuclear localization and promotes ribosome biosynthesis in hepatocellular carcinoma.

Ya-Hui Wang, Shan Huang, Lei Zhu, Qin Yang, Xiao-Mei Yang, Jian-ren Gu, Zhigang Zhang, Hui-Zhen Nie, Jun Li

Biochemical and Biophysical Research Communications - BBRC

DOI

2019

Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-β signaling

Jun Li, Ya-Hui Wang, Mingze Ma, Shuheng Jiang, Xue-Li Zhang, Yan-Li Zhang, Xiaomei Yang, Chun-Jie Xu, Guang-Ang Tian, Qing Li, Yang Wang, Lei Zhu, Hui-Zhen Nie, M. Feng, Q. Xia, Jian-ren Gu, Qing Xu, Zhigang Zhang

EBioMedicine

DOI

2019

Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor

Ming Wang, B-L Ni, Chun Zhuang, Wen-Yi Zhao, L. Tu, Xin-Li Ma, Lin-Xi Yang, Zhigang Zhang, Hui Cao

Cancer Medicine

DOI

2019

Neurotransmitters: emerging targets in cancer

Shuheng Jiang, Lipeng Hu, Xu Wang, Jun Li, Zhigang Zhang

Oncogene

DOI

2019

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6

Chun-Jie Xu, Guang-Ang Tian, Chun-hui Jiang, Hanbing Xue, Manzila Kuerbanjiang, Long-ci Sun, Lei Gu, Hong Zhou, Ye Liu, Zhigang Zhang, Qing Xu

Cell Death and Disease

DOI

2019

GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway

Xiao-Xin Zhang, B-L Ni, Qing Li, Lipeng Hu, Shuheng Jiang, Rong-kun Li, Guang-Ang Tian, Li-Li Zhu, Jun Li, Xue-Li Zhang, Yan-Li Zhang, Xiao-Mei Yang, Qin Yang, Ya-Hui Wang, Chun-Chao Zhu, Zhigang Zhang

Journal of experimental & clinical cancer research : CR

DOI

2019

Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1

Yong-Sheng Jiang, Rui-Zhe He, Yu-Hong Jiang, De-Jun Liu, Ling-Ye Tao, Min-Wei Yang, Chao-Yi Lin, Yang Shen, Xue-Liang Fu, Jian-Yu Yang, Jiao Li, Y. Huo, R. Hua, Wei Liu, Jun-Feng Zhang, Baiyong Shen, Zhigang Zhang, Yong-Wei Sun

Cell Death and Disease

DOI

2019

Lysyl oxidase promotes liver metastasis of gastric cancer via facilitating the reciprocal interactions between tumor cells and cancer associated fibroblasts

Qing Li, Chun-Chao Zhu, B-L Ni, Zi-Zhen Zhang, Shuheng Jiang, Lipeng Hu, Xu Wang, Xiao-Xin Zhang, Pei-Qi Huang, Qin Yang, Jun Li, Jian-ren Gu, Jia Xu, K. Luo, Gang Zhao, Zhigang Zhang

EBioMedicine

DOI

2019

THZ1 reveals CDK7-dependent transcriptional addictions in pancreatic cancer

P. Lu, Jing Geng, Lei Zhang, Yu Wang, Ning-Ning Niu, Yuan Fang, Fang Liu, Juan-Juan Shi, Zhigang Zhang, Yong-Wei Sun, Li-wei Wang, Yu-Jie Tang, J. Xue

Oncogene

DOI

2019

GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner

Shuheng Jiang, Li-Li Zhu, Man Zhang, Rong-kun Li, Qin Yang, Jiang-Yu Yan, Ce Zhang, Jian-Yu Yang, Fangyuan Dong, Miao Dai, Lipeng Hu, Jun Li, Qing Li, Ya-Hui Wang, Xiao-Mei Yang, Yan-Li Zhang, Hui-Zhen Nie, Lei Zhu, Xue-Li Zhang, Guang-Ang Tian, Xiao-Xin Zhang, Xiao-Yan Cao, Ling-Ye Tao, Shan Huang, Yong-Sheng Jiang, R. Hua, Kathy Qian Luo, Jian-ren Gu, Yong-Wei Sun, Shangwei Hou, Zhigang Zhang

Gut

DOI

2019

Understanding genetic features of pancreatic neoplasm.

Jin He, Zhigang Zhang, Xianjun Yu

Chinese Clinical Oncology

DOI

2019

1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis

Junping Zheng, Lin Zhu, Baifei Hu, Xiaojuan Zou, Haiming Hu, Zhigang Zhang, Nan Jiang, Jun Ma, Huabing Yang, Hongtao Liu

The Journal of Nutritional Biochemistry

DOI

2018

膏方治疗慢性阻塞性肺疾病稳定期研究进展

张志刚，柏正平

《湖南中医杂志》

2018

Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma

Huan Lu, Dandan Ju, Guang-Dong Yang, Lin-Yan Zhu, Xiao-Mei Yang, Jun Li, Wei-Wei Song, Jin-hao Wang, Can-can Zhang, Zhigang Zhang, Rong Zhang

EBioMedicine

DOI

2018

Integrin α9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling

Yan-Li Zhang, Xin Xing, Libo Cai, Lei Zhu, Xiao-Mei Yang, Ya-Hui Wang, Qin Yang, Hui-Zhen Nie, Zhigang Zhang, Jun Li, Xue-Li Zhang

Journal of Immunological Research

DOI

2018

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

Shu-Jie Zhao, Yifei Shen, Qing Li, Yunjie He, Yun-Kun Zhang, Lipeng Hu, Yuqing Jiang, Nan-wei Xu, Yu-Ji Wang, Jun Li, Ya-Hui Wang, Fei Liu, Rong Zhang, Guo-Yong Yin, Jin-Hai Tang, Dong Zhou, Zhigang Zhang

Cell Death and Disease

DOI

2018

Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis

Lipeng Hu, Xiao-Xin Zhang, Shuheng Jiang, Ling-Ye Tao, Qing Li, Li-Li Zhu, Ming-Wei Yang, Y. Huo, Yong-Sheng Jiang, Guang-Ang Tian, Xiao-Yan Cao, Yan-Li Zhang, Qin Yang, Xiao-Mei Yang, Ya-Hui Wang, Jun Li, G. Xiao, Yong-Wei Sun, Zhigang Zhang

Clinical Cancer Research

DOI

2018

Proceedings of the 3rd International Conference for Cancer Metabolism and Therapy, October 12–14, 2018, Shanghai, China

G. Xiao, Zhigang Zhang, B. Lu, Hongyang Wang, T. Fan, L. Boros, Ping Gao, Yue Pan, V. L. Go

Pancreas

DOI

2018

FGFRL1 Promotes Ovarian Cancer Progression by Crosstalk with Hedgehog Signaling

Haiyan Tai, Zhiyong Wu, Su'an Sun, Zhigang Zhang, Congjian Xu

Journal of Immunological Research

DOI

2018

SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways.

Yan-Li Zhang, Qing Li, Xiao-Mei Yang, F. Fang, Jun Li, Ya-Hui Wang, Qin Yang, Lei Zhu, Hui-Zhen Nie, Xue-Li Zhang, M. Feng, Shuheng Jiang, Guang-Ang Tian, Lipeng Hu, Ho-Yyoung Lee, Su-Jae Lee, Q. Xia, Zhigang Zhang

Cancer Research

DOI

2018

PD-L1 Expression Predicts a Distinct Prognosis in Krukenberg Tumor with Corresponding Origins

Haiyan Tai, Qin Yang, Zhiyong Wu, Su'an Sun, R. Cao, Yan-Feng Xi, Ran Zhao, Mengyu Zhang, Zhigang Zhang, Congjian Xu

Journal of Immunological Research

DOI

2018

Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.

Xiao-Mei Yang, Xiao-Yan Cao, P. He, Jun Li, M. Feng, Yan-Li Zhang, Xue-Li Zhang, Ya-Hui Wang, Qin Yang, Lei Zhu, Hui-Zhen Nie, Shuheng Jiang, Guang-Ang Tian, Xiao-Xin Zhang, Qiang Liu, J. Ji, Xuefeng Zhu, Q. Xia, Zhigang Zhang

Gastroenterology

DOI

2018

S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma

Yifei Shen, Shu-Jie Zhao, Shenyu Wang, Xiaohui Pan, Yun-Kun Zhang, Jing-Wen Xu, Yuqing Jiang, Haibo Li, Qiang Zhang, Jian-Bo Gao, Qin Yang, Yang Zhou, Shuheng Jiang, Hui-Lin Yang, Zhigang Zhang, Rong Zhang, Jun Li, Dong Zhou

EBioMedicine

DOI

2018

Molecular analysis of gastric cancer identifies genomic markers of drug sensitivity in Asian gastric cancer

Qin Yang, Chun-Chao Zhu, Yan-Li Zhang, Yang-Yang Wang, Ya-Hui Wang, Lei Zhu, Xiaomei Yang, Jun Li, Hui-Zhen Nie, Shuheng Jiang, Xiao-Xin Zhang, Xiao-Yan Cao, Qing Li, Xue-Li Zhang, Guang-Ang Tian, Lipeng Hu, Li-Li Zhu, Gang Zhao, Zhigang Zhang

Journal of Cancer

DOI

2018

SRSF10-mediated IL1RAP alternative splicing regulates cervical cancer oncogenesis via mIL1RAP-NF-κB-CD47 axis

Fei Liu, M. Dai, Qin-Yang Xu, Xiaolu Zhu, Yang Zhou, Shuheng Jiang, Ya-Hui Wang, Zhi-Hong Ai, Li Ma, Yan-Li Zhang, Lipeng Hu, Qin Yang, Jun Li, Shu-Jie Zhao, Zhigang Zhang, Yincheng Teng

Oncogene

DOI

2018

IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer.

Wei-Zhi He, Jinghua Wu, Juan-Juan Shi, Y. Huo, Wentao Dai, Jing Geng, P. Lu, Min-Wei Yang, Yuan Fang, Wei Wang, Zhigang Zhang, Aida Habtezion, Yong-Wei Sun, J. Xue

Cancer Research

DOI

2018

Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC.

Xiao-Yan Cao, Xiao-Xin Zhang, Min-Wei Yang, Lipeng Hu, Shuheng Jiang, Guang-Ang Tian, Li-Li Zhu, Qing Li, Yong-Wei Sun, Zhigang Zhang

Biochemical and Biophysical Research Communications - BBRC

DOI

2017

归芥膏治疗慢性肛周湿疹(血虚型)的临床研究

张志刚，邹勇，王雨来，熊仁海，程凯，孔赛

《时珍国医国药》

2017

Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer.

Shuheng Jiang, Li-Li Zhu, Jian-Yu Yang, Lipeng Hu, Jian-ren Gu, Xin Xing, Yong-Wei Sun, Zhigang Zhang

Biochemical and Biophysical Research Communications - BBRC

DOI

2017

Targeting mTORC2 component rictor inhibits cell proliferation and promotes apoptosis in gastric cancer.

Yu Bian, Jia Xu, Wen-Yi Zhao, Zi-Zhen Zhang, L. Tu, Hui Cao, Zhigang Zhang

American journal of translational research

2017

Cholesterol Synthetase DHCR24 Induced by Insulin Aggravates Cancer Invasion and Progesterone Resistance in Endometrial Carcinoma

M. Dai, Xiao-Lu Zhu, Fei Liu, Qin-Yang Xu, Qiu-Lin Ge, Shuheng Jiang, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing-Kai Wu, Zhi-Hong Ai, Yincheng Teng, Zhigang Zhang

Scientific Reports

DOI

2017

Expression of key mTOR pathway components in pancreatic ductal adenocarcinoma: A multicenter study for clinicopathologic and prognostic significance.

Li Zhou, D. Yuan, Zhigang Zhang, Zhi-Yong Liang, Wei-Xun Zhou, Jian-Yu Yang, Shuheng Jiang, Junliang Lu, Tai-Ping Zhang, L. You, Junchao Guo, Yu-Pei Zhao

Cancer Letters

DOI

2017

ITGBL1 Predicts a Poor Prognosis and Correlates EMT Phenotype in Gastric Cancer

Rong-Kun Li, Chun Zhuang, Shuheng Jiang, Nan Du, Wen-Yi Zhao, L. Tu, Hui Cao, Zhigang Zhang, Xiao-Fei Chen

Journal of Cancer

DOI

2017

Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase

He Yu, Shuheng Jiang, X. Bu, Jia-hua Wang, J. Weng, Xiao-Mei Yang, Kun He, Zhigang Zhang, P. Ao, Jun Xu, Min-Juan Xu

Scientific Reports

DOI

2017

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice.

Shuheng Jiang, Jun Li, Fangyuan Dong, Jian-Yu Yang, De-Jun Liu, Xiao-Mei Yang, Ya-Hui Wang, Min-Wei Yang, Xue-Liang Fu, Xiao-Xin Zhang, Qing Li, X. Pang, Y. Huo, Jiao Li, Jun-Feng Zhang, Ho-Yyoung Lee, Su-Jae Lee, Wen-Xin Qin, Jian-ren Gu, Yong-Wei Sun, Zhigang Zhang

Gastroenterology

DOI

2016

柴胡加龙骨牡蛎汤治疗原发性失眠临床观察

王玲姝，李翊，张志刚

《陕西中医》

2016

脊柱内固定术后血肿的预防及中药十灰丸干预作用研究

陈永恩，卢国樑，王新强，冯永洪，李真，邹健，张志刚，余伟宏

《深圳中西医结合杂志》

2016

Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells.

Lei Zhu, Guang-Ang Tian, Qin Yang, Gejing De, Zhigang Zhang, Ya-Hui Wang, Hui-Zhen Nie, Yan-Li Zhang, Xiaomei Yang, Jun Li

Oncology Report

DOI

2016

CXCL12-CXCR7 axis contributes to the invasive phenotype of pancreatic cancer

Junchao Guo, Jian Li, Li Zhou, Jian-Yu Yang, Zhigang Zhang, Zhi-Yong Liang, Wei-Xun Zhou, L. You, Tai-Ping Zhang, Yu-Pei Zhao

OncoTarget

DOI

2016

Long non-coding RNA LINC00628 functions as a gastric cancer suppressor via long-range modulating the expression of cell cycle related genes

Zi-Zhen Zhang, Gang Zhao, Chun Zhuang, Yan-Ying Shen, Wen-Yi Zhao, Jia Xu, Ming Wang, Chao-Jie Wang, L. Tu, Hui Cao, Zhigang Zhang

Scientific Reports

DOI

2016

CCBE1 promotes GIST development through enhancing angiogenesis and mediating resistance to imatinib

Guang-Ang Tian, Chun-Chao Zhu, Xiao-Xin Zhang, Lei Zhu, Xiao-Mei Yang, Shuheng Jiang, Rong-kun Li, L. Tu, Yang Wang, Chun Zhuang, P. He, Qing Li, Xiao-Yan Cao, Hui Cao, Zhigang Zhang

Scientific Reports

DOI

2015

保元汤合血府逐瘀汤治疗气虚血瘀型冠心病临床观察

张志刚，边文贵

《中西医结合心血管病电子杂志》

2015

Mineralocorticoid receptor suppresses cancer progression and the Warburg effect by modulating the miR‐338‐3p‐PKLR axis in hepatocellular carcinoma

Hui-Zhen Nie, Jun Li, Xiao-Mei Yang, Qingzhen Cao, M. Feng, Feng Xue, Lin Wei, W. Qin, Jian-ren Gu, Q. Xia, Zhigang Zhang

Hepatology

DOI

2015

Corrigendum: Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma

Jian-Yu Yang, Shuheng Jiang, De-Jun Liu, Xiao-Mei Yang, Y. Huo, Jiao Li, R. Hua, Zhigang Zhang, Yong-Wei Sun

Scientific Reports

DOI

2015

Elevated Rictor expression is associated with tumor progression and poor prognosis in patients with gastric cancer.

Yu-Hai Bian, Zheng-Shi Wang, Jia Xu, Wen-Yi Zhao, Hui Cao, Zhigang Zhang

Biochemical and Biophysical Research Communications - BBRC

DOI

2015

CHRM3 is a novel prognostic factor of poor prognosis in patients with endometrial carcinoma.

Ya-Hui Wang, Jun Li, Shan-Yun Wen, Xiaomei Yang, Yan-Li Zhang, Zhijie Wang, Zhigang Zhang

American journal of translational research

2015

TEM7 (PLXDC1), a key prognostic predictor for resectable gastric cancer, promotes cancer cell migration and invasion.

Zi-Zhen Zhang, R. Hua, Jun-Feng Zhang, Wen-Yi Zhao, En-Hao Zhao, L. Tu, Chao-Jie Wang, Hui Cao, Zhigang Zhang

American Journal of Cancer Research

2015

Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma

Jian-Yu Yang, Shuheng Jiang, De-Jun Liu, Xiao-Mei Yang, Y. Huo, Jiao Li, R. Hua, Zhigang Zhang, Yong-Wei Sun

Scientific Reports

DOI

2015

High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis.

H. Yi, Jun Ye, Xiao-Mei Yang, Liwen Zhang, Zhigang Zhang, Ya-Ping Chen

International Journal of Clinical and Experimental Pathology

2015

CTHRC1 promotes human colorectal cancer cell proliferation and invasiveness by activating Wnt/PCP signaling.

Xiao-Mei Yang, H. You, Qing Li, Hong Ma, Ya-Hui Wang, Yan-Li Zhang, Lei Zhu, Hui-Zhen Nie, W. Qin, Zhigang Zhang, Jun Li

International Journal of Clinical and Experimental Pathology

2015

Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling.

P. He, Shuheng Jiang, Mingze Ma, Yang Wang, Rong-Kun Li, F. Fang, Guang-Ang Tian, Zhigang Zhang

Molecular Medicine Reports

DOI

2015

Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway

Rong-kun Li, Wen-Yi Zhao, F. Fang, Chun Zhuang, Xiao-Xin Zhang, Xiao-Mei Yang, Shuheng Jiang, Fan-zhi Kong, L. Tu, Wen-Ming Zhang, Sheng-li Yang, Hui Cao, Zhigang Zhang

Journal of Cancer Research and Clinical Oncology

DOI

2015

Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer

Shuheng Jiang, Yang Wang, Jian-Yu Yang, Jun Li, M. Feng, Ya-Hui Wang, Xiao-Mei Yang, P. He, Guang-Ang Tian, Xiao-Xin Zhang, Qing Li, Xiao-Yan Cao, Y. Huo, Min-Wei Yang, Xue-Liang Fu, Jiao Li, De-Jun Liu, M. Dai, Shan-Yun Wen, Jian-ren Gu, Jie Hong, R. Hua, Zhigang Zhang, Yong-Wei Sun

OncoTarget

DOI

2015

Silencing of MICAL-L2 suppresses malignancy of ovarian cancer by inducing mesenchymal-epithelial transition.

Lin-Yan Zhu, Wen-Ming Zhang, Xiao-Mei Yang, L. Cui, Jun Li, Yan-Li Zhang, Ya-Hui Wang, Jun-Ping Ao, Mingze Ma, Huan Lu, Yuan Ren, Shaobin Xu, Guang-Dong Yang, Wei-Wei Song, Jinghao Wang, Xiao-Dan Zhang, Rong Zhang, Zhigang Zhang

Cancer Letters

DOI

2014

中药抗宫颈癌HPV感染的研究进展

孔赛，韩凤娟，张志刚

《世界中西医结合杂志》

2014

龚正丰教授治疗膝骨性关节炎经验介绍

张志刚，刘锦涛

《新中医》

DOI

2014

CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt/PCP-Rho signaling.

Mingze Ma, Chun Zhuang, Xiao-Mei Yang, Zi-Zhen Zhang, Hong Ma, Wen-Ming Zhang, H. You, W. Qin, Jian-ren Gu, Sheng-Li Yang, Hui Cao, Zhigang Zhang

Neoplasia

DOI

2014

Microfilament regulatory protein MENA increases activity of RhoA and promotes metastasis of hepatocellular carcinoma.

Ling-Yun Lin, Xiao-Mei Yang, Jun Li, Yan-Li Zhang, W. Qin, Zhigang Zhang

Experimental Cell Research

DOI

2014

Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis through RGD-mediated integrin activation

M. Feng, Mingze Ma, Yingyu Fu, Jun Li, Tao Wang, Feng Xue, Jian-jun Zhang, W. Qin, Jian-ren Gu, Zhigang Zhang, Q. Xia

Molecular Cancer

DOI

2014

DNA methylation-mediated silencing of matricellular protein dermatopontin promotes hepatocellular carcinoma metastasis by α3β1 integrin-Rho GTPase signaling

Yingyu Fu, M. Feng, Jian Yu, Mingze Ma, Xiao-jin Liu, Jun Li, Xiao-Mei Yang, Ya-Hui Wang, Yan-Li Zhang, Jun-Ping Ao, Feng Xue, W. Qin, Jianren Gu, Q. Xia, Zhigang Zhang

OncoTarget

DOI

2014

PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.

Shuheng Jiang, P. He, Mingze Ma, Yang Wang, Rong-kun Li, F. Fang, Yingyu Fu, Guang-Ang Tian, W. Qin, Zhigang Zhang

International Journal of Clinical and Experimental Pathology

2014

Monoamine oxidase A suppresses hepatocellular carcinoma metastasis by inhibiting the adrenergic system and its transactivation of EGFR signaling.

Jun Li, Xiao-Mei Yang, Ya-Hui Wang, M. Feng, Xiao-jin Liu, Yan-Li Zhang, Shuo-Wen Huang, Zheng Wu, Feng Xue, W. Qin, Jian-ren Gu, Q. Xia, Zhigang Zhang

Journal of Hepatology

DOI

2014

HER4 is a novel prognostic biomarker in gastrointestinal stromal tumor specifically originated from stomach.

Wen-Yi Zhao, Chun Zhuang, Jia Xu, Ming Wang, Zi-Zhen Zhang, L. Tu, Chao-Jie Wang, Tian-long Ling, Hui Cao, Zhigang Zhang

American Journal of Cancer Research

2014

Somatostatin receptors in gastrointestinal stromal tumors: new prognostic biomarker and potential therapeutic strategy.

Wen-Yi Zhao, Chun Zhuang, Jia Xu, Ming Wang, Zi-Zhen Zhang, L. Tu, Chao-Jie Wang, Tian-long Ling, Hui Cao, Zhigang Zhang

American journal of translational research

2014

LRG1 is an independent prognostic factor for endometrial carcinoma

Shan-Yun Wen, Li-Na Zhang, Xiao-Mei Yang, Yan-Li Zhang, Li Ma, Qiu-Lin Ge, Shuheng Jiang, Xiao-Lu Zhu, Wei Xu, Wen-Jing Ding, Bing-qing Yang, Zhigang Zhang, Yincheng Teng

Tumor Biology

DOI

2014

Silencing of WISP3 suppresses gastric cancer cell proliferation and metastasis and inhibits Wnt/β-catenin signaling.

F. Fang, Wen-Yi Zhao, Rong-kun Li, Xiao-Mei Yang, Jun Li, Jun-Ping Ao, Shuheng Jiang, Fan-zhi Kong, L. Tu, Chun Zhuang, W. Qin, P. He, Wen-Ming Zhang, Hui Cao, Zhigang Zhang

International Journal of Clinical and Experimental Pathology

2014

Rictor is an independent prognostic factor for endometrial carcinoma.

Shan-Yun Wen, Chang-hua Li, Yan-Li Zhang, Yu Bian, Li Ma, Qiu-Lin Ge, Yincheng Teng, Zhigang Zhang

International Journal of Clinical and Experimental Pathology

2014

SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis.

Guang-Dong Yang, Xiao-Mei Yang, Huan Lu, Yuan Ren, Mingze Ma, Lin-Yan Zhu, Jinghao Wang, Wei-Wei Song, Wen-Ming Zhang, Rong Zhang, Zhigang Zhang

International Journal of Clinical and Experimental Pathology

2014

Cytohesin-3 is upregulated in hepatocellular carcinoma and contributes to tumor growth and vascular invasion.

Yingyu Fu, Jun Li, M. Feng, Xiao-Mei Yang, Ya-Hui Wang, Yan-Li Zhang, W. Qin, Q. Xia, Zhigang Zhang

International Journal of Clinical and Experimental Pathology

2014

Co-occurrence of driver and passenger bacteria in human colorectal cancer

Jia-Wei Geng, Qing Song, Xiao-Dan Tang, Xiao Liang, Hong Fan, Hai-Ling Peng, Qiang Guo, Zhigang Zhang

Gut Pathogens

DOI

2013

小切口撬拨植骨斯氏针内固定术治疗移位跟骨骨折30例

张志刚，姜宏，朱利民，徐坤林

《湖南中医杂志》

2013

中西医结合治疗干眼症20例

张志刚

《河南中医》

2013

郑钦安学术思想特色撷要

张志刚

《陕西中医药大学学报》

2013

中西医结合治疗急性卡他性结膜炎70例

张志刚

《河南中医》

2013

中西医结合治疗早期老年性白内障临床研究

张志刚

《中医学报》

2013

Diversified pattern of the human colorectal cancer microbiome

Jia-Wei Geng, Hong Fan, Xiao-Dan Tang, Hui-Qin Zhai, Zhigang Zhang

Gut Pathogens

DOI

2012

脑血疏通口服液治疗轻中度血管性痴呆的临床研究

张志刚，顼宝玉，刘晴

《中西医结合心脑血管病杂志》

2012

MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells

Zheng Wu, Zhiyong Wu, Jun Li, Xiaomei Yang, Ya-Hui Wang, Yi Yu, Jun Ye, Congjian Xu, W. Qin, Zhigang Zhang

Tumor Biology

DOI

2011

通络解毒汤治疗强直性脊柱炎32例

张志刚，李红卫，徐坤林，俞峰

《湖南中医杂志》

2011

两种方法治疗老年性股骨粗隆间骨折疗效对比分析

张志刚，俞峰，刘锦涛，吉万波

《湖南中医杂志》

2011

膝痹通治疗膝骨性关节炎52例

宋建春，张志刚，刘锦涛

《湖南中医杂志》

2010

古方愈重证3则

张志刚

《陕西中医》

2010

切开复位内固定联合中药治疗肱骨远端粉碎性骨折27例临床观察

李红卫，张志刚，姜宏

《江苏中医药》

2009

血管性痴呆中西医研究进展

张志刚，顼宝玉

《中西医结合心脑血管病杂志》

2009

中西医结合治疗糖尿病周围神经病变45例观察

张志刚，王远芝

《首都食品与医药》

2009

大黄虫丸治疗肾纤维化血瘀证的临床研究

金亚明，殷敏，邓跃毅，何立群，朱戎，张志刚，张春菘，钟逸斐，张金福

《中国中西医结合肾病杂志》

2006

微创Gamma钉内固定治疗老年股骨转子间骨折36例

张志刚，陈贤敏

《湖南中医杂志》

2003

牛蒡子防治STZ糖尿病大鼠早期肾脏病变的实验研究

贺学林，章素云，陈以平，邓跃毅，张志刚，郭慕依

《浙江中医杂志》

1993

中医骨伤科学

张志刚

《科学出版社》

1984

山东省第二期伤骨科学习班结业

张志刚

《山东中医药大学学报》

会议论文

2022

针刺联合运动疗法治疗脑出血后肢体功能障碍的疗效观察

连露露，范小璇，赵晓平，张志刚，司泽钰，王凯

《2022年中国针灸学会年会论文集》

DOI

2006

老年女性胸腰段骨质疏松性脊柱压缩骨折患者的肺功能变化

赵刘军，杨惠林，张志刚，牛国琦，梁道臣，顾晓辉，唐天驷，朱蓉梅

《浙江省中西医结合学会骨伤科专业委员会第十二次学术年会、杭州市中医药协会骨伤科专业委员会第一次学术年会暨继续教育学习班》

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