官道刚｜南方医科大学｜学者主页

2026

基于知识感知图谱的药物重定向模型预测三阴性乳腺癌治疗药物及验证

吴迪恒，徐展发，李镱，张明旭，林嘉泽，吕祎君，官道刚，秦耿耿

《南方医科大学学报》

2026

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

Qinwen Liu, Haojie Chen, Xiaofeng Li, Jingxin Liu, Yiwen Li, Zhenyi Shi, Shenshen Guo, Qingfeng Du, Aiping Lü, Daogang Guan

Advanced Science

DOI

2026

[Prediction and verification of therapeutic drugs for triple-negative breast cancer using a knowledge graph-based drug repurposing model].

Diheng Wu, Zhanfa Xu, Yi Li, Mingxu Zhang, Jiaze Lin, Yijun Lü, Daogang Guan, Genggeng Qin

PubMed

DOI

2026

Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer

Yi Li, Diheng Wu, Zhenyi Shi, Qian Luo, Wenyue Deng, Q Liu, Aiping Lü, Weiguo Chen, Genggeng Qin, Daogang Guan

Journal of Translational Medicine

DOI

2026

Combining network pharmacology and multi-omics reveals the role of Shengdihuang-Huangqi herb pair in alleviating type 2 diabetes mellitus

Xianglin Cao, Yuhan Shang, Mengyao Qu, Qiuxia Kang, Yifan Xu, Qiang Wang, Shuaishuai Xie, Daogang Guan, Jianjun Chen

Phytomedicine

DOI

2025

基于网络药理学及实验验证分析二至丸抗肝纤维化的作用机制

钟晓宇，李镱，陈星梅，刘琴文，樊奇灵，官道刚，罗柳婷，艾美雪，朱志博

《肿瘤药学》

2025

基于系统药理学优化模型对苓桂术甘汤治疗心力衰竭的机制研究

陈嘉莹，李镱，刘培增，官道刚，梁杰贤，王晟

《暨南大学学报(自然科学与医学版)》

2025

SuHeXiang Wan in the treatment of stroke: Prediction potentially active metabolites using a combination of in silico analysis and experimental viability assessment

Lingyu Shen, Wenxing Li, Yupeng Chen, Daogang Guan, Aiping Lü, Anqi Xu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2025

Betulinic Acid Self‐Assembled Nanodelivery System Attenuates Osteoarthritis by Dually Modulating Macrophage Polarization and Macrophage‐Chondrocyte Crosstalk via Disruption of the GSK3β/NF‐κB/CCL20 Axis

Qin‐Wen Liu, Yupeng Chen, Xiaoyan Zhuang, Jingxin Liu, Haojie Chen, Zhenyi Shi, Xiang Li, Yiwen Li, Qian Luo, Hangtian Wu, Yanpeng Lin, Wanling He, Runjie Yu, Yi Li, Xiaohong Gong, Maolin Wang, Jun Wang, Jianjun Chen, Aiping Lü, Cheng Zhou, Daogang Guan

Small

DOI

2025

A Novel Network Pharmacology Strategy for Retrieving a Key Functional Component Group and Mechanisms in the Di-Huang-Yin-Zi Treatment of Parkinson's Disease

Qi Qu, Yanfei Tong, Yi Li, Han Zhang, Jianhua Yang, Zongwei Cai, Siqiang Ren, Daogang Guan, Shaogang Qu

Current Neuropharmacology

DOI

2025

Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis

Yanhong Liu, Wenqi Li, Jingxiao Chen, Yi Li, Jieqi Cai, Yongxi Luo, Jiahao Lin, Lu Chen, Aiping Lü, Daogang Guan, Huiyong Xu

BMC Complementary Medicine and Therapies

DOI

2025

Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis

Yanpeng Lin, Hangtian Wu, Jun Wang, Wanling He, Jiahui Hou, Vidmi Taolam Martin, Chencheng Zhu, Yupeng Chen, Junyuan Zhong, Bin Yu, Aiping Lü, Daogang Guan, Genggeng Qin, Weiguo Chen

ACS Nano

DOI

2025

TRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism

Yu Zeng, Liqian Zhao, Kunlin Zeng, Ziling Zhan, Zhengming Zhan, Shangbiao Li, Hongchao Zhan, Peng Chai, Cheng Xie, Shengfeng Ding, Yuxin Xie, Li Ping Wang, Cuiying Li, Xiaoxia Chen, Daogang Guan, Enguang Bi, Jian-you Liao, Fan Deng, Xiaochun Bai, Ye Song, Aidong Zhou

Journal of Clinical Investigation

DOI

2024

茵陈蒿汤治疗肝纤维化的核心功能成分群以及潜在通路

陈星梅，刘琴文，李镱，钟晓宇，樊奇灵，马柯，罗柳婷，官道刚，朱志博

《南方医科大学学报》

2024

[Analysis of core functional components in Yinchenhao Decoction and their pathways for treating liver fibrosis].

Xiaojun Chen, Qifa Liu, Yuan Li, Xiaomei Zhong, Qin Fan, Ke Ma, Limei Luo, Daogang Guan, Zhibo Zhu

PubMed

DOI

2024

Zwitterion‐Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age‐Associated Osteoarthritis

Jiahui Hou, Yanpeng Lin, Chencheng Zhu, Yupeng Chen, Rongmin Lin, Hancheng Lin, Dahai Liu, Daogang Guan, Bin Yu, Jun Wang, Hangtian Wu, Zhuang Cui

Advanced Science

DOI

2024

T cell senescence may contribute to immunothrombosis via Th17 immune transition in COVID-19

Wenxing Li, Rui Qian, Zhaoming Zhou, Lei Wen, Quan Yin, Xiang Ping Zhou, Xiaowei Li, Jie Cheng, Xinlu Zhang, Xin Zeng, Zhuoya Wang, Yingying Huang, Shengqiang Wang, Yixing Liao, Youjiang Li, Shu Shan, Meijuan Zhou, Wei Wu, Amir Abdollahi, Avery August, Nicholas Magazine, Gianluca Veggiani, Weishan Huang, Daogang Guan, Cheng Zhou

《中国科学通报：英文版》

DOI

2024

Ozone-delivering nanocomposite hydrogel for acute Staphylococcus aureus osteomyelitis treatment via neutrophil regulation

Hangtian Wu, Yihuang Lin, Yanpeng Lin, Mingye Deng, Jiahui Hou, Dahai Liu, Zhuang Cui, Daogang Guan, Jun Wang, Bin Yu

Chemical Engineering Journal

DOI

2024

A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis

Qin‐Wen Liu, Xiaowei Li, Yi Li, Qian Luo, Qiling Fan, Aiping Lü, Daogang Guan, Jiahui Li

Chinese Medicine

DOI

2024

Injectable Ozone‐Rich Nanocomposite Hydrogel Loaded with D‐Mannose for Anti‐Inflammatory and Cartilage Protection in Osteoarthritis Treatment

Hangtian Wu, Jun Wang, Yanpeng Lin, Wanling He, Jiahui Hou, Mingye Deng, Yupeng Chen, Qin‐Wen Liu, Aiping Lü, Zhuang Cui, Daogang Guan, Bin Yu

Small

DOI

2024

Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel computational pharmacological model

Qin‐Wen Liu, Qian Luo, Qiling Fan, Yi Li, Aiping Lü, Daogang Guan

BMC Complementary Medicine and Therapies

DOI

2023

System pharmacology-based determination of the functional components and mechanisms in chronic heart failure treatment: an example of Zhenwu decoction

Yisheng Huang, Qin‐Wen Liu, Meiyu Liu, Liqian Xu, Yi Li, Quanlin Chen, Daogang Guan, Jindong Xu, Chunshui Lin, Sheng Wang

Journal of Biomolecular Structure and Dynamics

DOI

2023

A highly stretchable, adhesive, and antibacterial hydrogel with chitosan and tobramycin as dynamic cross-linkers for treating the infected diabetic wound

Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Daniel Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qin‐Wen Liu, Daogang Guan, Jun Wang, Chuan‐Zhi Duan

Carbohydrate Polymers

DOI

2023

Corrigendum: An integrative pharmacology model for decoding the underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid arthritis

Jie Wu, Kexin Wang, Qin‐Wen Liu, Yi Li, Yi Li, Yingying Huang, Yujie Liu, Jieqi Cai, Chuanhui Yin, Xiaowei Li, Hailang Yu, Wei Meng, Handuo Wang, Aiping Lü, Yazi Li, Yazi Li, Daogang Guan

Frontiers in Pharmacology

DOI

2023

Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation

Anqi Xu, Wenxing Li, Jieqi Cai, Zhuohua Wen, Kexin Wang, Yupeng Chen, Xifeng Li, Daogang Guan, Chuanzhi Duan

BMC Complementary Medicine and Therapies

DOI

2023

Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer

Jieqi Cai, Yupeng Chen, Kexin Wang, Yi Li, Jie Wu, Hailang Yu, Qingping Li, Qi Wu, Wei Meng, Handuo Wang, Aiping Lü, Mianbo Huang, Genxia Wei, Daogang Guan

BMC Complementary Medicine and Therapies

DOI

2023

A Metabolic Driven Bio‐Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis

Kexin Wang, Chuanhui Yin, Xiangmin Ye, Quanlin Chen, Jie Wu, Yupeng Chen, Yi Li, Jun Wang, Chuanzhi Duan, Aiping Lü, Daogang Guan

Small

DOI

2022

Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer

Xiaoyi Zhang, Kexin Wang, Hui Dai, Jieqi Cai, Yujie Liu, Chuanhui Yin, Jie Wu, Xiaowei Li, Guiyong Wu, Aiping Lü, Qin‐Wen Liu, Daogang Guan

Frontiers in Pharmacology

DOI

2022

ReDisX, a machine learning approach, rationalizes rheumatoid arthritis and coronary artery disease patients uniquely upon identifying subpopulation differentiation markers from their genomic data

Hiu Fung Yip, Debajyoti Chowdhury, Kexin Wang, Yujie Liu, Yao Gao, Liang Lan, Chaochao Zheng, Daogang Guan, Kei Fong Lam, Hailong Zhu, Xue‐Cheng Tai, Aiping Lü

Frontiers in Medicine

DOI

2022

Mathematical algorithm–based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San

Wenxia Gong, Kexin Wang, Xueyuan Wang, Yupeng Chen, Xuemei Qin, Aiping Lü, Daogang Guan

Frontiers in Cell and Developmental Biology

DOI

2022

Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma

Kexin Wang, Xiangmin Ye, Chuanhui Yin, Qing Ren, Yupeng Chen, Xuemei Qin, Chuanzhi Duan, Aiping Lü, Li Gao, Daogang Guan

Frontiers in Cell and Developmental Biology

DOI

2022

An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis

Jie Wu, Kexin Wang, Qin‐Wen Liu, Yi Li, Yi Li, Yingying Huang, Yujie Liu, Jieqi Cai, Chuanhui Yin, Xiaowei Li, Hailang Yu, Wei Meng, Handuo Wang, Aiping Lü, Yazi Li, Yazi Li, Daogang Guan

Frontiers in Pharmacology

DOI

2022

Uncovering Hidden Mechanisms of Different Prescriptions Treatment for Osteoporosis via Novel Bioinformatics Model and Experiment Validation

Yujie Liu, Qin‐Wen Liu, Chuanhui Yin, Yi Li, Jie Wu, Quanlin Chen, Hailang Yu, Aiping Lü, Daogang Guan

Frontiers in Cell and Developmental Biology

DOI

2021

A System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer

Yi Li, Kexin Wang, Yupeng Chen, Jieqi Cai, Xuemei Qin, Aiping Lü, Daogang Guan, Genggeng Qin, Weiguo Chen

Frontiers in Pharmacology

DOI

2021

Computational Network Pharmacology–Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression

Kexin Wang, Kai Li, Yupeng Chen, Genxia Wei, Hailang Yu, Yi Li, Meng Wei, Handuo Wang, Li Gao, Aiping Lü, Junxiang Peng, Daogang Guan

Frontiers in Pharmacology

DOI

2021

Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model

Lang Yang, Liuyi Fan, Kexin Wang, Yupeng Chen, Lan Liang, Xuemei Qin, Aiping Lü, Peng Cao, Bin Yu, Daogang Guan, Junxiang Peng

Oxidative Medicine and Cellular Longevity

DOI

2020

Rapid Development of Targeting circRNAs in Cardiovascular Diseases

Chao Zhang, Si Tong Huo, Zhi‐Yong Wu, Lina Chen, Chang Wen, Honghao Chen, William Weidong Du, Nan Wu, Daogang Guan, Sen Lian, Burton B. Yang

Molecular Therapy — Nucleic Acids

DOI

2020

A Loop‐Based and AGO‐Incorporated Virtual Screening Model Targeting AGO‐Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice

Zhenjian Zhuo, Youyang Wan, Daogang Guan, Shuaijian Ni, Luyao Wang, Zongkang Zhang, Jin Liu, Chao Liang, Yuanyuan Yu, Aiping Lü, Ge Zhang, Bao‐Ting Zhang

Advanced Science

DOI

2020

Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis

Qingqing Guo, Li Li, Kang Zheng, Guang Zheng, Haiyang Shu, Yingjie Shi, Cheng Chang Lu, Jun Shu, Daogang Guan, Aiping Lü, Xiaojuan He

Journal of Leukocyte Biology

DOI

精选作品

期刊论文

基于知识感知图谱的药物重定向模型预测三阴性乳腺癌治疗药物及验证

Xanthatin Targets CISD1 to Drive Ferroptosis and Mitophagy as a Dual Anticancer Strategy in Triple‐Negative Breast Cancer

[Prediction and verification of therapeutic drugs for triple-negative breast cancer using a knowledge graph-based drug repurposing model].

Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer

Combining network pharmacology and multi-omics reveals the role of Shengdihuang-Huangqi herb pair in alleviating type 2 diabetes mellitus

基于网络药理学及实验验证分析二至丸抗肝纤维化的作用机制

基于系统药理学优化模型对苓桂术甘汤治疗心力衰竭的机制研究

SuHeXiang Wan in the treatment of stroke: Prediction potentially active metabolites using a combination of in silico analysis and experimental viability assessment

Betulinic Acid Self‐Assembled Nanodelivery System Attenuates Osteoarthritis by Dually Modulating Macrophage Polarization and Macrophage‐Chondrocyte Crosstalk via Disruption of the GSK3β/NF‐κB/CCL20 Axis

A Novel Network Pharmacology Strategy for Retrieving a Key Functional Component Group and Mechanisms in the Di-Huang-Yin-Zi Treatment of Parkinson's Disease

Using computational pharmacology and experimental verification to decode mechanism of Qing-Wei-San in treating periodontitis

Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis

TRAF3 loss protects glioblastoma cells from lipid peroxidation and immune elimination via dysregulated lipid metabolism

茵陈蒿汤治疗肝纤维化的核心功能成分群以及潜在通路

[Analysis of core functional components in Yinchenhao Decoction and their pathways for treating liver fibrosis].

Zwitterion‐Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age‐Associated Osteoarthritis

T cell senescence may contribute to immunothrombosis via Th17 immune transition in COVID-19

Ozone-delivering nanocomposite hydrogel for acute Staphylococcus aureus osteomyelitis treatment via neutrophil regulation

A novel network pharmacology strategy to decode mechanism of Wuling Powder in treating liver cirrhosis

Injectable Ozone‐Rich Nanocomposite Hydrogel Loaded with D‐Mannose for Anti‐Inflammatory and Cartilage Protection in Osteoarthritis Treatment

Screening of the key response component groups and mechanism verification of Huangqi-Guizhi-Wuwu-Decoction in treating rheumatoid arthritis based on a novel computational pharmacological model

System pharmacology-based determination of the functional components and mechanisms in chronic heart failure treatment: an example of Zhenwu decoction

A highly stretchable, adhesive, and antibacterial hydrogel with chitosan and tobramycin as dynamic cross-linkers for treating the infected diabetic wound

Corrigendum: An integrative pharmacology model for decoding the underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid arthritis

Screening of key functional components of Taohong Siwu Decoction on ischemic stroke treatment based on multiobjective optimization approach and experimental validation

Decoding the key compounds and mechanism of Shashen Maidong decoction in the treatment of lung cancer

A Metabolic Driven Bio‐Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis

Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer

ReDisX, a machine learning approach, rationalizes rheumatoid arthritis and coronary artery disease patients uniquely upon identifying subpopulation differentiation markers from their genomic data

Mathematical algorithm–based identification of the functional components and mechanisms in depression treatment: An example of Danggui-Shaoyao-San

Computational Metabolomics Reveals the Potential Mechanism of Matrine Mediated Metabolic Network Against Hepatocellular Carcinoma

An Integrative Pharmacology Model for Decoding the Underlying Therapeutic Mechanisms of Ermiao Powder for Rheumatoid Arthritis

Uncovering Hidden Mechanisms of Different Prescriptions Treatment for Osteoporosis via Novel Bioinformatics Model and Experiment Validation

A System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer

Computational Network Pharmacology–Based Strategy to Capture Key Functional Components and Decode the Mechanism of Chai-Hu-Shu-Gan-San in Treating Depression

Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model

Rapid Development of Targeting circRNAs in Cardiovascular Diseases

A Loop‐Based and AGO‐Incorporated Virtual Screening Model Targeting AGO‐Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice

Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis

预印本

ReDisX: a Continuous Max Flow-based framework to redefine the diagnosis of diseases based on identified patterns of genomic signatures

System Pharmacology-Based Strategy to Investigate Core Component Group and Molecular Mechanisms of Xuefu Zhuyu Decoction in the Treatment of Gbm

Interpret The Synergistic Mechanism of Shenfu Decoction in Treating Sick Sinus Syndrome From the Perspective of Systematic Pharmacology

研究方向