刘琼｜深圳大学｜学者主页

2026

An Engineered Nano‐Vesicle Adjuvant Platform (ENAP) for Cytokine Delivery Enables a Novel Antigen‐Coordinated Vaccine Against Helicobacter pylori

Yi-Wan Shang, Xi-Ran Zhang, Lin-Wei Li, Xiao-Min Yu, Lingbing Zeng, Yanli Cao, Ziwei Tao, Lu Shen, Shuaishuai Zhang, Chuang-Ye Yang, Huizhen Tian, Ying Liang, Hanchen Liao, Xiao-Tian Huang, Qiong Liu

Journal of Extracellular Vesicles

DOI

2026

The Role and Therapeutic Potential of Gut Microbiota and Their Extracellular Vesicles in Neurological, Cardiovascular, and Metabolic Diseases.

Zhi-Rong Rao, Lin-Wei Li, Ying Liang, Xiao-Tian Huang, Qiong Liu

Clinical and Translational Gastroenterology

DOI

2025

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

Qiong Liu, Biao-Xian Li, Jin-Rong Ma, Xiao Lei, Jun-Peng Ma, Yanyan Da, Zhi-Yong Zhou, Jiaqi Tao, Xin-Yi Ren, Ting Zeng, Zhi-Ting Xie, Hai-Yan Lin, Zihui Jin, Yi Wan, Liang Zhang, Donglin Lai, Ya-Ping Guo, Jing Li, Yi-Wan Shang, Lu Shen, Ziwei Tao, Tian Gong, Cheng-Sheng Zhang

Journal of Extracellular Vesicles

DOI

2025

Consistency in bacterial extracellular vesicle production: key to their application in human health

Ke-cheng Dai, Bo Liao, Xiao-Tian Huang, Qiong Liu

Extracellular Vesicles and Circulating Nucleic Acids

DOI

2025

Mitochondrial complex III subunit Qcr8 regulates the virulence and adhesion of Candida albicans by modulating mitochondrial function

Qian-Jun Zhao, Xiao-Tian Huang, Qiong Liu, Yanli Cao, Xiao-Min Yu, Yan-Ling Liu, Ni-Ya Hu, Zhen-Ning Han, Junjun Tan, Xuan Li, Yeming Zhang, Kai Wang, Yu-ting Li, Lingbing Zeng

Microbiology spectrum

DOI

2025

A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in Candida albicans

Junjun Tan, Qiong Liu, Zhi-Ping Liu, Yanli Cao, Xiao-Min Yu, Qian-Jun Zhao, Ni-Ya Hu, Yan-Ling Liu, Yuwei Wan, Yeming Zhang, Huizhen Tian, Lingbing Zeng, Xiao-Tian Huang

mBio

DOI

2025

Hypoglycemic effect of C. butyricum-pMTL007-GLP-1 engineered probiotics on type 2 diabetes mellitus

Dexi Zhou, Sheng-Jie Li, Gang Hu, Yu-Fan Wang, Zhanghua Qi, Xuan Xu, Jing Wei, Qiong Liu, Ting-Tao Chen

Gut microbes

DOI

2025

Advances and Challenges in Helicobacter pylori Subunit Vaccine Development: Antigen Candidates and Immunization Strategies.

Zhili Liu, He Li, Xiao-Tian Huang, Qiong Liu

Journal of Applied Microbiology

DOI

2024

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

Qiong Liu, Yi-Wan Shang, Ziwei Tao, Xuan Li, Lu Shen, Han-Chi Zhang, Zhili Liu, Zhi-Ying Rao, Xiao-Min Yu, Yanli Cao, Lingbing Zeng, Xiao-Tian Huang

bioRxiv

DOI

2024

Damage-associated molecular patterns in viral infection: potential therapeutic targets

Huizhen Tian, Qiong Liu, Xiao-Min Yu, Yanli Cao, Xiao-Tian Huang

Critical reviews in microbiology

DOI

2024

Icariin ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the S100 calcium binding protein A6/β-catenin/c-Myc signaling pathway.

Huizhen Tian, Qi Pan, Jianfeng Wu, Juanjuan Liao, Yuwei Wan, Ke Pei, Qiong Liu, Lingbing Zeng, Yanli Cao, Qiao-Fa Shi, Nan-Zhen Kuang, Lijuan Sun, Xiao-Min Yu, Xiao-Tian Huang

Phytomedicine

DOI

2024

Adjuvants for Helicobacter pylori vaccines: Outer membrane vesicles provide an alternative strategy

Han-Chi Zhang, Zhili Liu, Yi Li, Ziwei Tao, Lu Shen, Yi-Wan Shang, Xiao-Tian Huang, Qiong Liu

Virulence

DOI

2024

Animal Models of Helicobacter pylori Infection and Vaccines: Current Status and Future Prospects

Zhili Liu, He Li, Xiao-Tian Huang, Qiong Liu

Helicobacter

DOI

2024

Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in mice

Qiong Liu, Yi-Wan Shang, Lu Shen, Xiao-Min Yu, Yanli Cao, Lingbing Zeng, Han-Chi Zhang, Zirong Rao, Yi Li, Ziwei Tao, Zhili Liu, Xiao-Tian Huang

Virulence

DOI

2023

Insights into the regulatory role of bacterial sncRNA and its extracellular delivery via OMVs

Mengdan He, Shuanshuan Yin, Xin-Lei Huang, Yi Li, Biao-Xian Li, Tian Gong, Qiong Liu

Applied Microbiology and Biotechnology

DOI

2023

Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.

Xiao-Min Yu, Yejia Zhang, Ke Pei, Junjun Tan, Huizhen Tian, Tian Xu, Fa-Di Liu, Nanqin Peng, Yilin Huang, Xin-Ying Huang, Xin-Lei Huang, Jianfeng Wu, Qiong Liu, Lingbing Zeng, Wei Hua, Xiao-Tian Huang

Food & Function

DOI

2023

Recombinant outer membrane vesicles delivering eukaryotic expression plasmid of cytokines act as enhanced adjuvants against Helicobacter pylori infection in mice

Qiong Liu, Biao-Xian Li, Jia-Hui Lu, Yejia Zhang, Yi-Wan Shang, Yi Li, Tian Gong, Cheng-Sheng Zhang

Infection and Immunity

DOI

2022

Interactions among microorganisms open up a new world for anti‐infectious therapy

Yejia Zhang, Han-Chi Zhang, Tian Xu, Lingbing Zeng, Fa-Di Liu, Xiao-Tian Huang, Qiong Liu

The FEBS Journal

DOI

2022

Disruption of sncRNA Improves the Protective Efficacy of Outer Membrane Vesicles against Helicobacter pylori Infection in a Mouse Model

Biao-Xian Li, Yilian Xu, Tian Xu, Zhicheng Guo, Qianwen Xu, Yi Li, Ling-Bing Zeng, Xiao-Tian Huang, Qiong Liu

Infection and Immunity

DOI

2022

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

Lingbing Zeng, Yongcheng Huang, Junjun Tan, J. Peng, Ni-Ya Hu, Qiong Liu, Yanli Cao, Yuping Zhang, Junzhu Chen, Xiao-Tian Huang

bioRxiv

DOI

2022

Cell pyroptosis in picornavirus and its potential for treating viral infection

Zheng Wang, Hao-Lin Yu, Wen-Yue Zhuang, Jingxuan Chen, Yi Jiang, Zhicheng Guo, Xiao-Tian Huang, Qiong Liu

Journal of Medical Virology

DOI

2022

A Complete Genome of Nocardia terpenica NC_YFY_NT001 and Pan-Genomic Analysis Based on Different Sources of Nocardia spp. Isolates Reveal Possibly Host-Related Virulence Factors

Qinming Cai, Yongcheng Huang, Li Zhou, Ni-Ya Hu, Yan-Ling Liu, Fujia Guo, Qiong Liu, Xiao-Tian Huang, Yun-Yi Zhang, Lingbing Zeng

Infection and Drug Resistance

DOI

2022

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis

Yejia Zhang, Tian Xu, Huizhen Tian, Jianfeng Wu, Xiao-Min Yu, Lingbing Zeng, Fa-Di Liu, Qiong Liu, Xiao-Tian Huang

Cancers

DOI

2022

Extracellular vesicles, a novel model linking bacteria to ferroptosis in the future?

Yi Li, Zhicheng Guo, Tian Xu, Ye Zhang, Lingbing Zeng, Xiao-Tian Huang, Qiong Liu

Applied Microbiology and Biotechnology

DOI

2021

Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital

Yan-Ling Liu, Yiqing Lin, Zi-Wen Wang, Ni-Ya Hu, Qiong Liu, Wenkai Zhou, Xiuzhen Li, Long-Hua Hu, Jian Guo, Xiao-Tian Huang, L. Zeng

Frontiers in Cellular and Infection Microbiology

DOI

2021

Outer Membrane Vesicles Derived from Salmonella enterica Serotype Typhimurium Can Deliver Shigella flexneri 2a O-Polysaccharide Antigen To Prevent Shigella flexneri 2a Infection in Mice

Huizhen Tian, Biao-Xian Li, Tian Xu, Hao-Lin Yu, Jingxuan Chen, Haiyan Yu, Shanglin Li, L. Zeng, Xiao-Tian Huang, Qiong Liu

Applied and Environmental Microbiology

DOI

2021

Molecular Epidemiology, Antifungal Susceptibility, and Virulence Evaluation of Candida Isolates Causing Invasive Infection in a Tertiary Care Teaching Hospital

Junzhu Chen, Ni-Ya Hu, Hong-Zhi Xu, Qiong Liu, Xiao-Min Yu, Yuping Zhang, Yongcheng Huang, Junjun Tan, Xiao-Tian Huang, L. Zeng

Frontiers in Cellular and Infection Microbiology

DOI

2020

阿尔茨海默症与2型糖尿病的共病机制及硒与钒的作用

何志军，陈杰瑞，薛华，黄柳梅，刘琼

《生命科学》

DOI

2020

Efficacy and Safety of Oncolytic Viruses in Randomized Controlled Trials: A Systematic Review and Meta-Analysis

Zengbin Li, Zeju Jiang, Yingxuan Zhang, Xiao-Tian Huang, Qiong Liu

Cancers

DOI

2020

Immunization With Outer Membrane Vesicles Derived From Major Outer Membrane Protein-Deficient Salmonella Typhimurium Mutants for Cross Protection Against Salmonella Enteritidis and Avian Pathogenic Escherichia coli O78 Infection in Chickens

Yuxuan Chen, Kai-Wen Jie, Biao-Xian Li, Haiyan Yu, Huan Ruan, Jing Wu, Xiao-Tian Huang, Qiong Liu

Frontiers in Microbiology

DOI

2020

CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis

Hongxia Zhang, L. Zeng, Qiong Liu, Guilin Jin, Jieyu Zhang, Zengbin Li, Yilian Xu, Huizhen Tian, Shanshan Deng, Qiao-Fa Shi, Xiao-Tian Huang

bioRxiv

DOI

2020

Outer Membrane Vesicles of Helicobacter pylori 7.13 as Adjuvants Promote Protective Efficacy Against Helicobacter pylori Infection

Zifan Song, Biao-Xian Li, Yingxuan Zhang, Rui-Zhen Li, Huan Ruan, Jing Wu, Qiong Liu

Frontiers in Microbiology

DOI

2020

Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms

Rui-Zhen Li, Qiong Liu

Frontiers in Materials

DOI

2020

Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control

Junzhu Chen, Qiong Liu, L. Zeng, Xiao-Tian Huang

Frontiers in Microbiology

DOI

2020

TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis

Daiwei Wang, Hong Qi, Haoxing Zhang, Wei Zhou, Yanpeng Li, Ang Li, Qiong Liu, Yun Wang

International Journal of Biological Sciences

DOI

2019

Orally-administered Outer-membrane vesicles from Helicobacter pylori reduce H. pylori infection via Th2-biased immune responses in mice.

Qiong Liu, Xiuzhen Li, Yingxuan Zhang, Zifan Song, Rui-Zhen Li, Huan Ruan, Xiao-Tian Huang

Pathogens and Disease

DOI

2019

Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy

Yingxuan Zhang, Zheyan Fang, Rui-Zhen Li, Xiao-Tian Huang, Qiong Liu

Cancers

DOI

2019

sncRNAs packaged by Helicobacter pylori outer membrane vesicles attenuate IL-8 secretion in human cells.

Hongxia Zhang, Yingxuan Zhang, Zifan Song, Rui-Zhen Li, Huan Ruan, Qiong Liu, Xiao-Tian Huang

International Journal of Medical Microbiology

DOI

2019

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

Zengbin Li, Zi-Xiao Zou, Zeju Jiang, Xiao-Tian Huang, Qiong Liu

Viruses

DOI

2019

Anti‐CRISPR proteins targeting the CRISPR‐Cas system enrich the toolkit for genetic engineering

Qiong Liu, Hongxia Zhang, Xiao-Tian Huang

The FEBS Journal

DOI

2018

Outer Membrane Vesicles: Current Status and Future Direction of These Novel Vaccine Adjuvants

Kuang Tan, Rui-Zhen Li, Xiao-Tian Huang, Qiong Liu

Frontiers in Microbiology

DOI

2017

Characterization of the Same Mutations in FCA1 Gene Associated With 5-FC Resistance of Candida albicans

Xi-Ren Deng, Fu-Cai Wang, M. Ying, Jie-Yu Zhang, Ying Ying, L. Zeng, Xue-Fei Hu, Ke Wang, Qiong Liu, Xiao-Tian Huang

DOI

2016

应用遗传改造的沙门菌介导肿瘤治疗的研究进展

梁康，赵新新，易洁，刘琼，刘青，孔庆科

《生物工程学报》

2014

虾青素与Ⅱ型糖尿病研究进展

邹欣蓉，刘琼，毛玉山，徐雷艇，习阳，步世忠

《中国海洋药物》

2013

菌株漂浮性对其柴油降解特性的影响

罗群，张建国，侯登勇，何颖，王庆蓉，刘琼，沈先荣

《环境科学与技术》

2013

2型糖尿病环境因素与DNA甲基化的研究进展

汤琳琳，刘琼，步世忠，徐雷艇，王钦文，麦一峰，段世伟

《遗传》

2012

硒缺乏与阿尔茨海默症

刘琼，田静，陈平，杨思林，宋云

《生命科学》

精选作品

期刊论文

An Engineered Nano‐Vesicle Adjuvant Platform (ENAP) for Cytokine Delivery Enables a Novel Antigen‐Coordinated Vaccine Against Helicobacter pylori

The Role and Therapeutic Potential of Gut Microbiota and Their Extracellular Vesicles in Neurological, Cardiovascular, and Metabolic Diseases.

Development of a Recombinant Outer Membrane Vesicles (OMVs)‐Based Vaccine Against Helicobacter pylori Infection in Mice

Consistency in bacterial extracellular vesicle production: key to their application in human health

Mitochondrial complex III subunit Qcr8 regulates the virulence and adhesion of Candida albicans by modulating mitochondrial function

A small heat shock protein Fmp28 influences virulence by regulating Als3 expression via the cAMP-PKA signaling pathway in Candida albicans

Hypoglycemic effect of C. butyricum-pMTL007-GLP-1 engineered probiotics on type 2 diabetes mellitus

Advances and Challenges in Helicobacter pylori Subunit Vaccine Development: Antigen Candidates and Immunization Strategies.

Coxsackievirus group B3 regulates ASS1-mediated metabolic reprogramming and promotes macrophage inflammatory polarization in viral myocarditis

Damage-associated molecular patterns in viral infection: potential therapeutic targets

Icariin ameliorates Coxsackievirus B3-induced viral myocarditis by modulating the S100 calcium binding protein A6/β-catenin/c-Myc signaling pathway.

Adjuvants for Helicobacter pylori vaccines: Outer membrane vesicles provide an alternative strategy

Animal Models of Helicobacter pylori Infection and Vaccines: Current Status and Future Prospects

Outer membrane vesicles from genetically engineered Salmonella enterica serovar Typhimurium presenting Helicobacter pylori antigens UreB and CagA induce protection against Helicobacter pylori infection in mice

Insights into the regulatory role of bacterial sncRNA and its extracellular delivery via OMVs

Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.

Recombinant outer membrane vesicles delivering eukaryotic expression plasmid of cytokines act as enhanced adjuvants against Helicobacter pylori infection in mice

Interactions among microorganisms open up a new world for anti‐infectious therapy

Disruption of sncRNA Improves the Protective Efficacy of Outer Membrane Vesicles against Helicobacter pylori Infection in a Mouse Model

QCR7 affects the virulence of Candida albicans and the uptake of multiple carbon sources present in different host niches

Cell pyroptosis in picornavirus and its potential for treating viral infection

A Complete Genome of Nocardia terpenica NC_YFY_NT001 and Pan-Genomic Analysis Based on Different Sources of Nocardia spp. Isolates Reveal Possibly Host-Related Virulence Factors

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis

Extracellular vesicles, a novel model linking bacteria to ferroptosis in the future?

Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital

Outer Membrane Vesicles Derived from Salmonella enterica Serotype Typhimurium Can Deliver Shigella flexneri 2a O-Polysaccharide Antigen To Prevent Shigella flexneri 2a Infection in Mice

Molecular Epidemiology, Antifungal Susceptibility, and Virulence Evaluation of Candida Isolates Causing Invasive Infection in a Tertiary Care Teaching Hospital

阿尔茨海默症与2型糖尿病的共病机制及硒与钒的作用

Efficacy and Safety of Oncolytic Viruses in Randomized Controlled Trials: A Systematic Review and Meta-Analysis

Immunization With Outer Membrane Vesicles Derived From Major Outer Membrane Protein-Deficient Salmonella Typhimurium Mutants for Cross Protection Against Salmonella Enteritidis and Avian Pathogenic Escherichia coli O78 Infection in Chickens

CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreatitis

Outer Membrane Vesicles of Helicobacter pylori 7.13 as Adjuvants Promote Protective Efficacy Against Helicobacter pylori Infection

Engineered Bacterial Outer Membrane Vesicles as Multifunctional Delivery Platforms

Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control

TAF1L promotes development of oral squamous cell carcinoma via decreasing autophagy-dependent apoptosis

Orally-administered Outer-membrane vesicles from Helicobacter pylori reduce H. pylori infection via Th2-biased immune responses in mice.

Design of Outer Membrane Vesicles as Cancer Vaccines: A New Toolkit for Cancer Therapy

sncRNAs packaged by Helicobacter pylori outer membrane vesicles attenuate IL-8 secretion in human cells.

Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development

Anti‐CRISPR proteins targeting the CRISPR‐Cas system enrich the toolkit for genetic engineering

Outer Membrane Vesicles: Current Status and Future Direction of These Novel Vaccine Adjuvants

Characterization of the Same Mutations in FCA1 Gene Associated With 5-FC Resistance of Candida albicans

应用遗传改造的沙门菌介导肿瘤治疗的研究进展

虾青素与Ⅱ型糖尿病研究进展

菌株漂浮性对其柴油降解特性的影响

2型糖尿病环境因素与DNA甲基化的研究进展

硒缺乏与阿尔茨海默症

会议论文

船舶舱底油污水生物处理研究

方格星虫多糖对环境因素复合作用大鼠生物效应及代谢物的影响

环境条件对海洋石油降解菌Y9中AlkB基因表达的影响

海洋星虫多糖质量标准研究

海洋油污染微生物处理系统的研制

方格星虫多糖降低放疗引起的小鼠骨髓损伤