底洁卉｜徐州医科大学｜学者主页

2026

Single- and dual-target CAR-T cells targeting HBsAg and GPC3 to balance safety and antitumor efficacy in HBV-positive hepatocellular carcinoma

Quan-Gang Chen, Zihan Chen, Deqin Xu, Hu Wang, An-Kang Hu, Zhihui Hu, Peng Gao, Hui-Zhong Li, Yan Li, Liang Sun, Ke-Yu Gao, Hui Hou, Jiehui Di, Keli Chai, Bao Zhu, Qing Zhang, Gang Wang, Wei Xu, Zheng-Xiang Han, Junnian Zheng, Yong Liu

iScience

DOI

2025

Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling

Jiehui Di, Zhong-Jun Zhao, Mingyi Xia, Ke-Yu Gao, Keli Chai, Bao Zhu, Wanping Sun, Yanping Zhang, Junnian Zheng, Yong Liu

Cell Death and Disease

DOI

2024

Nucleolin malonylation as a nuclear-cytosol signal exchange mechanism to drive cell proliferation in Hepatocarcinoma by enhancing AKT translation

Liang Sun, Hanjing Meng, Tao Liu, Qiong Zhao, Mingyi Xia, Zhong-Jun Zhao, Yuting Qian, Hao Cui, Xuefei Zhong, Keli Chai, Yang Tian, Yang Sun, Bao Zhu, Jiehui Di, Guang-Hou Shui, Lianjun Zhang, Junnian Zheng, Shu-Tao Guo, Yong Liu

Journal of Biological Chemistry

DOI

2023

CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma

Guang Zhao, Zhong-Jun Zhao, Mingyi Xia, Lishun Xiao, Bao Zhu, Hui Wang, Xiang Li, Jiehui Di

Scientific Reports

DOI

2023

Role of plectin and its interacting molecules in cancer

Ke-Yu Gao, Zhimin Gao, Mingyi Xia, Hailong Li, Jiehui Di

Medical Oncology

DOI

2022

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

Bing-Wu Wang, JianJong Gao, Zhongjun Zhao, X. Zhong, Hao Cui, H. Hou, Yan-Ping Zhang, Junnian Zheng, Jiehui Di, Yong Liu

Molecular Medicine

DOI

2022

The functions, oncogenic roles, and clinical significance of circular RNAs in renal cell carcinoma

Hui Huang, Tao Chen, Fei Li, D. Jin, Chuanjiang Li, Yongbo Yang, X. Liu, Dong-Miao Wang, Jiehui Di

Medical Oncology

DOI

2021

CPEB2-p53负反馈环路在肾癌中的作用及机制研究

底洁卉

《哈尔滨工业大学》

2021

A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration.

Jiehui Di, Guang Zhao, Hui Wang, Yao-Yao Wu, Zhongjun Zhao, B. Zhu, Yan-Ping Zhang, Jun-Nian Zheng, Yong Liu, Ying Hu

Journal of genetics and genomics = Yi chuan xue bao

DOI

2021

CircUBAP2 enhances autophagy and promotes colon cancer progression and metastasis via miR-582-5p/FOXO1 signaling.

Fei-Fei Chen, Lei Guo, Jiehui Di, Man Li, D. Dong, D. Pei

Journal of genetics and genomics = Yi chuan xue bao

DOI

2017

p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B

Jiehui Di, Juan-Juan Tang, He-Ya Qian, D. Franklin, C. Deisenroth, Yoko Itahana, Jun-Nian Zheng, Yan-Ping Zhang

OncoTarget

DOI

2017

Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma

Jiehui Di, Ke-Yu Gao, Debao Qu, Yao-Yao Wu, Jing Yang, Jun-Nian Zheng

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

DOI

2016

Rap2B GTPase: structure, functions, and regulation

Zhesi Zhu, Jiehui Di, Zheng Lu, Ke-Yu Gao, Jun-Nian Zheng

Tumor Biology

DOI

2016

Identification of hypomethylation profile of Ki-67 promoter in vitro and in vivo

Lian-Tao Li, G. Qian, Hui Tian, Jiehui Di, Fei-Fei Chen, Jun-Nian Zheng

2016

Structure, functional regulation and signaling properties of Rap2B.

Debao Qu, Hui Huang, Jiehui Di, Ke-Yu Gao, Zheng Lu, Jun-Nian Zheng

Oncology Letters

DOI

2016

Rap2B promotes cell proliferation, migration and invasion in prostate cancer

Jiehui Di, Huan Cao, Juangjuan Tang, Zheng Lu, Ke-Yu Gao, Zhesi Zhu, Jun-Nian Zheng

Medical Oncology

DOI

2015

Retraction: ‘p53‐induced Rap2B positively regulates migration in cells exposed to glucose deprivation’ by D.‐S. Pei, J.‐H. Di, W.‐Q. Du and J.‐N. Zheng

Dong-Sheng Pei, Jiehui Di, Wen-qi Du, Jun-Nian Zheng

Molecular Carcinogenesis

DOI

2015

p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading

Jiehui Di, Hui Huang, Yan Wang, Debao Qu, Juan-Juan Tang, Qian Cheng, Zheng Lu, Yan-Ping Zhang, Jun-Nian Zheng

Journal of Cancer Research and Clinical Oncology

DOI

2015

p53-mediated autophagic regulation: A prospective strategy for cancer therapy.

Juan-Juan Tang, Jiehui Di, Huan Cao, J. Bai, Jun-Nian Zheng

Cancer Letters

DOI

2015

Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

Jiehui Di, Hui Huang, Debao Qu, Juangjuan Tang, Wen-Jia Cao, Zheng Lu, Qian Cheng, Jing Yang, J. Bai, Yan-Ping Zhang, Jun-Nian Zheng

Scientific Reports

DOI

2015

Role of Rap2 and its Downstream Effectors in Tumorigenesis.

Hui Huang, Jiehui Di, Debao Qu, Zhen Gao, Yan-Ping Zhang, Jun-Nian Zheng

Anti-Cancer Agents in Medicinal Chemistry

DOI

2014

Rap2B promotes migration and invasion of human suprarenal epithelioma

Jiehui Di, Debao Qu, Zheng Lu, Lian-Tao Li, Qian Cheng, Y. Xin, Long-Zhen Zhang, Yan-Ping Zhang, Jun-Nian Zheng

Tumor Biology

DOI

2012

IRF1 suppresses Ki-67 promoter activity through interfering with Sp1 activation

Fei-Fei Chen, Jianning Song, Jiehui Di, Qing Zhang, Hui Tian, Jun-Nian Zheng

Tumor Biology

DOI

2012

Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

Hui Tian, Bao-Fu Zhang, Jiehui Di, G. Jiang, Fei-Fei Chen, Hui-Zhong Li, Lian-Tao Li, D. Pei, Jun-Nian Zheng

Cancer Letters

DOI

2012

MDA-7/IL-24 Induces Bcl-2 Denitrosylation and Ubiquitin-Degradation Involved in Cancer Cell Apoptosis

Hui Tian, Jing Wang, Bao-Fu Zhang, Jiehui Di, Fei-Fei Chen, Hui-Zhong Li, Lian-Tao Li, D. Pei, Jun-Nian Zheng

PLoS ONE

DOI

2012

EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF RGD-mda-7, A HIS-TAGGED mda-7/IL-24 MUTANT PROTEIN

Jun-Jie Liu, Bao-Fu Zhang, Xiao-Xing Yin, Dong-Sheng Pei, Zhi-Xia Yang, Jiehui Di, Fei-Fei Chen, Hui-Zhong Li, Wei Xu, Yong-Ping Wu, Jun-Nian Zheng

Journal of immunoassay & immunochemistry

DOI

2012

Critical Role of Lysine 123 in the Ubiquitin-Mediated Degradation of MDA-7/IL-24

Hui Tian, Lian-Tao Li, Bao-Fu Zhang, Jiehui Di, Fei-Fei Chen, Hui-Zhong Li, Jun-Jie Liu, D. Pei, Jun-Nian Zheng

Journal of Interferon and Cytokine Research

DOI

2011

A critical role of Sp1 transcription factor in regulating the human Ki-67 gene expression

Hui Tian, G. Qian, Wang Li, Fei-Fei Chen, Jiehui Di, Bao-Fu Zhang, Dong-Sheng Pei, P. Ma, Jun-Nian Zheng

Tumor Biology

DOI

2011

Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach.

Jiehui Di, Y. Zhang, J. Zheng

Current Cancer Drug Targets

DOI

2011

Potent Antitumor Effect Elicited by RGD-mda-7, an mda-7/IL-24 Mutant, via Targeting the Integrin Receptor of Tumor Cells

Bao-Fu Zhang, Jun-Jie Liu, Dong-Sheng Pei, Zhi-Xia Yang, Jiehui Di, Fei-Fei Chen, Hui-Zhong Li, Wei Xu, Yong-Ping Wu, Jun-Nian Zheng

Cancer Biotherapy and Radiopharmaceuticals

DOI

2010

Oncolytic-adenovirus-expressed RNA interference for cancer therapy

Dong-Sheng Pei, Jiehui Di, Fei-Fei Chen, Jun-Nian Zheng

Expert Opinion on Biological Therapy

DOI

2009

含精氨酸-甘氨酸-天冬氨酸肽的白细胞介素-24突变体真核表达载体的构建及其体外抗肝癌作用

Wei Xu, Bao-Fu Zhang, Zhi-Xia Yang, Jiehui Di, Hai-Long Li, Xiao-Lei Sun, Chao Gao, Jun-Jie Liu, Yu-Ming Gu, Zheng-Xiang Han

底洁卉

精选作品

期刊论文

Single- and dual-target CAR-T cells targeting HBsAg and GPC3 to balance safety and antitumor efficacy in HBV-positive hepatocellular carcinoma

Rap2B drives tumorigenesis and progression of colorectal cancer through intestinal cytoskeleton remodeling

Nucleolin malonylation as a nuclear-cytosol signal exchange mechanism to drive cell proliferation in Hepatocarcinoma by enhancing AKT translation

CPEB2 inhibit cell proliferation through upregulating p21 mRNA stability in glioma

Role of plectin and its interacting molecules in cancer

Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

The functions, oncogenic roles, and clinical significance of circular RNAs in renal cell carcinoma

CPEB2-p53负反馈环路在肾癌中的作用及机制研究

A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration.

CircUBAP2 enhances autophagy and promotes colon cancer progression and metastasis via miR-582-5p/FOXO1 signaling.

p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B

Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma

Rap2B GTPase: structure, functions, and regulation

Identification of hypomethylation profile of Ki-67 promoter in vitro and in vivo

Structure, functional regulation and signaling properties of Rap2B.

Rap2B promotes cell proliferation, migration and invasion in prostate cancer

Retraction: ‘p53‐induced Rap2B positively regulates migration in cells exposed to glucose deprivation’ by D.‐S. Pei, J.‐H. Di, W.‐Q. Du and J.‐N. Zheng

p53 target gene Rap2B regulates the cytoskeleton and inhibits cell spreading

p53-mediated autophagic regulation: A prospective strategy for cancer therapy.

Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

Role of Rap2 and its Downstream Effectors in Tumorigenesis.

Rap2B promotes migration and invasion of human suprarenal epithelioma

IRF1 suppresses Ki-67 promoter activity through interfering with Sp1 activation

Keap1: one stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

MDA-7/IL-24 Induces Bcl-2 Denitrosylation and Ubiquitin-Degradation Involved in Cancer Cell Apoptosis

EXPRESSION, PURIFICATION, AND CHARACTERIZATION OF RGD-mda-7, A HIS-TAGGED mda-7/IL-24 MUTANT PROTEIN

Critical Role of Lysine 123 in the Ubiquitin-Mediated Degradation of MDA-7/IL-24

A critical role of Sp1 transcription factor in regulating the human Ki-67 gene expression

Reactivation of p53 by inhibiting Mdm2 E3 ligase: a novel antitumor approach.

Potent Antitumor Effect Elicited by RGD-mda-7, an mda-7/IL-24 Mutant, via Targeting the Integrin Receptor of Tumor Cells

Oncolytic-adenovirus-expressed RNA interference for cancer therapy

含精氨酸-甘氨酸-天冬氨酸肽的白细胞介素-24突变体真核表达载体的构建及其体外抗肝癌作用

会议论文

CPEB4 inhibit cell proliferation via upregulating p21 mRNA stability in Renal cell carcinoma

研究方向