张娜｜北京工业大学｜学者主页

2026

纳米药物递送系统调控干细胞样记忆T细胞在抗肿瘤治疗中的应用

刘昕睿，马青坪，张娜，刘永军

《药学学报》

2026

EcoRxAgent: an AI agent for generating economically substitutable prescriptions

Cheng Li, Pei-Yuan Lai, Na Zhang, Cai Wen, Hua Cai, G. Zheng, Hao Wu, Liang Liang, Guoqiong Zeng, Tian-Qi Yang, Xiao-Xia Yu, Li Li, Jian-Huang Lai, Changdong Wang, Tao Yu

npj Digital Medicine

DOI

2025

Natural small molecule thymoquinone increases the chemosensitivity of glioblastoma to temozolomide through inhibiting Wnt/β-catenin signaling pathway to downregulate MGMT expression: In vitro and in vivo validation

Peiying Bai, Peng Wang, Ting Ren, Qing Tang, Ziao Lin, Na Zhang, Lijiao Zhao, 钟儒刚, Guohui Sun

Biochemical Pharmacology

DOI

2025

Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression

Peiying Bai, Peng Wang, Ting Ren, Qing Tang, Na Zhang, Lijiao Zhao, 钟儒刚, Guohui Sun

European Journal of Medicinal Chemistry

DOI

2024

A Tween-80 modified hypoxia/esterase dual stimulus-activated nanomicelle as a delivery platform for carmustine - Design, synthesis, and biological evaluation

Duo Li, Ting Ren, Xiaoli Wang, Zhixuan Xiao, Guohui Sun, Na Zhang, Lijiao Zhao, 钟儒刚

International Journal of Biological Macromolecules

DOI

2024

Energy Blocker Lonidamine Reverses Nimustine Resistance in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis Disruption, and O 6 -Methylguanine-DNA Methyltransferase Downregulation: In Vitro and In Vivo Validation

Yaxing Huang, Peng Wang, Tengjiao Fan, Na Zhang, Lijiao Zhao, Rugang Zhong, Guohui Sun

ACS Pharmacology & Translational Science

DOI

2023

A multi-functional hypoxia/esterase dual stimulus responsive and hyaluronic acid-based nanomicelle for targeting delivery of chloroethylnitrosouea

Duo Li, Ting Ren, Yunxuan Ge, Xiaoli Wang, Guohui Sun, Na Zhang, Lijiao Zhao, Rugang Zhong

Journal of Nanobiotechnology

DOI

2022

“响应脱壳”介孔硅纳米系统共递送Tim-3单抗和索拉非尼增强肝癌化学免疫联合治疗

慕升君，桑晓，牟伟伟，王天琪，杨锐，张自鹏，刘永军，张娜

《药学学报》

DOI

2022

纳米递送系统在mRNA肿瘤疫苗中的研究进展

顾盼盼，高彤，刘永军，张娜

《药学学报》

2021

基于巨噬细胞的纳米仿生递药系统在肿瘤治疗中的应用

刘金虎，刘永军，张娜

《药学学报》

DOI

2021

单核/巨噬细胞载体药物递送系统的设计与进展

杨晗，张娜，刘永军

《中国新药杂志》

2020

Recent Advances in the Discovery of CK2 Allosteric Inhibitors: From Traditional Screening to Structure-Based Design

Xiaolan Chen, Chunqiong Li, Dada Wang, Yu Chen, Na Zhang

Molecules

DOI

2020

Chemopreventive Role of Apigenin against the Synergistic Carcinogenesis of Human Papillomavirus and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

Fangzheng Yin, Lijiao Zhao, Lili Zhang, Yuhe Chen, Guohui Sun, Jintao Li, Na Zhang, Yuancong Xu, Paul K.S. Chan, Rugang Zhong

Biomedicines

DOI

2020

Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation

Xiaodong Sun, Guohui Sun, Yaxin Huang, Shufen Zhang, Xiaoyu Tang, Na Zhang, Lijiao Zhao, Rugang Zhong, Yongzhen Peng

Toxicology

DOI

2019

脑胶质瘤中异柠檬酸脱氢酶突变及其抑制剂研究进展

张娜，黄嘉骏，林婉君，龙泽，黄晓明，杜晶晶，马文哲

《中国药学杂志》

2019

Molecular mechanism of point mutation-induced Monopolar spindle 1 (Mps1/TTK) inhibitor resistance revealed by a comprehensive molecular modeling study

Yan Han, Yun-Gang Wu, Yi Xu, Wen-Tao Guo, Na Zhang, Xiao-Yi Wang

PeerJ

DOI

2018

Structure‐based Discovery of Novel CK2α‐Binding Cyclic Peptides with Anti‐cancer Activity

Shan Tang, Na Zhang, Yue Zhou, Wilian Augusto Cortopassi, Matthew P. Jacobson, Lijiao Zhao, Rugang Zhong

Molecular Informatics

DOI

2017

IDO1天然小分子抑制剂的筛选及抗肿瘤作用研究

庞伟强，高磊，窦玥莹，刘璐，张娜，刘晓嘉，刘阳，杨兆勇，宋丹青，邓洪斌

《药学学报》

2017

Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents

Ming Bu, Tingting Cao, Hongxia Li, Mingzhou Guo, Burton B. Yang, Cheng‐Chu Zeng, Yue Zhou, Na Zhang, Liming Hu

Bioorganic & Medicinal Chemistry Letters

DOI

2017

Synthesis and biological evaluation of novel steroidal 5α,8α-endoperoxide derivatives with aliphatic side-chain as potential anticancer agents

Ming Bu, Tingting Cao, Hongxia Li, Mingzhou Guo, Burton B. Yang, Yue Zhou, Na Zhang, Cheng‐Chu Zeng, Liming Hu

Steroids

DOI

2017

Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU

Yameng Wang, Ting Ren, Xinxin Lai, Guohui Sun, Lijiao Zhao, Na Zhang, Rugang Zhong

ACS Medicinal Chemistry Letters

DOI

2016

刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展

慕升君，刘永军，张娜

《中国药学杂志》

2016

纳米凝胶载体系统的研究进展

李霏霏，张娜

《中国药学杂志》

2016

聚合物药物结合物胶束在抗肿瘤药物递送方面的研究进展

尹晓兰，张波，刘永军，张娜

《药学学报》

2014

纳米载体共递送化疗药物用于肿瘤联合治疗的研究进展

张波，张娜

《中国新药杂志》

2013

N-苯甲基靛红肟类JNK3抑制剂的分子对接及3D-QSAR研究(英文)

周玥，张娜，钟儒刚

Journal of Chinese Pharmaceutical Sciences

2012

羧甲基壳聚糖作为药物载体的研究进展

刘凤喜，张娜

《中国药学杂志》

2012

靶向血管内皮生长因子及其受体的抗肿瘤药物研究进展

张娜，姚文兵，徐晨

《国际药学研究杂志》

2011

空间稳定免疫脂质体用于抗肿瘤药物载体的研究进展

李菲，张娜，郭丰广，郝吉福，王建筑，曹娟

《中国药学杂志》

2009

Structural basis for decreased affinity of Emodin binding to Val66-mutated human CK2α as determined by molecular dynamics

Na Zhang, Rugang Zhong

Journal of Molecular Modeling

DOI

2008

阳离子固体脂质纳米粒/pDNA二元复合物的初步研究

刘春喜，叶杰胜，张娜，马春红，栾芳

《中国药学杂志》

2008

蛋白多肽类药物非注射给药途径的研究

张莉，毕茹，张娜

《药物分析杂志》

2007

载鱼精蛋白-pDNA复合物固体脂质纳米粒的初步研究

叶杰胜，张娜，马春红，黄桂华，栾芳

《中国药学杂志》

2007

核苷类抗癌、抗病毒靶向制剂的研究进展

刘剑峰，张娜，徐文方

《中国药学杂志》

2007

托氟啶脂质体的研究

孙维彤，张娜，李爱国，徐文方

《中国药学杂志》

2007

洛莫司汀热敏脂质体的制备及体外抗肿瘤活性研究

黄桂华，祝侠丽，张娜，张丙杰

《中国药学杂志》

2007

替莫唑胺固体脂质纳米粒在动物体内药动学及组织分布研究

毕秀丽，黄桂华，张娜，窦明金，顾纪锋

《中国药学杂志》

2007

SYBR Green Ⅰ-荧光法测定载鱼精蛋白缩合基因纳米粒中pDNA的含量和包封率

叶杰胜，张娜，马春红，黄桂华

《药物分析杂志》

2006

鱼精蛋白凝聚法测定脂质体和纳米脂质体包封率

孙维彤，黄桂华，叶杰胜，张娜

《中国药学杂志》

2006

肺靶向炎琥宁明胶微球的制备

张娜，黄桂华，席延伟，王晓波，徐文方

《中国药学杂志》

2005

人工神经网络结合药动学模型设计氯氮平非pH依赖型缓释片

李凌冰，张娜

《中国药学杂志》

2004

麦胚凝集素修饰的胰岛素脂质体对小鼠口服吸收的促进作用

张娜，平其能，徐文方

《中国药学杂志》

精选作品

期刊论文

纳米药物递送系统调控干细胞样记忆T细胞在抗肿瘤治疗中的应用

EcoRxAgent: an AI agent for generating economically substitutable prescriptions

Natural small molecule thymoquinone increases the chemosensitivity of glioblastoma to temozolomide through inhibiting Wnt/β-catenin signaling pathway to downregulate MGMT expression: In vitro and in vivo validation

Discovery of a novel Wnt inhibitor DK419: Reversing temozolomide resistance in glioblastoma by switching off Wnt/β-catenin signaling pathway to inhibit MGMT expression

A Tween-80 modified hypoxia/esterase dual stimulus-activated nanomicelle as a delivery platform for carmustine - Design, synthesis, and biological evaluation

Energy Blocker Lonidamine Reverses Nimustine Resistance in Human Glioblastoma Cells through Energy Blockade, Redox Homeostasis Disruption, and O 6 -Methylguanine-DNA Methyltransferase Downregulation: In Vitro and In Vivo Validation

A multi-functional hypoxia/esterase dual stimulus responsive and hyaluronic acid-based nanomicelle for targeting delivery of chloroethylnitrosouea

“响应脱壳”介孔硅纳米系统共递送Tim-3单抗和索拉非尼增强肝癌化学免疫联合治疗

纳米递送系统在mRNA肿瘤疫苗中的研究进展

基于巨噬细胞的纳米仿生递药系统在肿瘤治疗中的应用

单核/巨噬细胞载体药物递送系统的设计与进展

Recent Advances in the Discovery of CK2 Allosteric Inhibitors: From Traditional Screening to Structure-Based Design

Chemopreventive Role of Apigenin against the Synergistic Carcinogenesis of Human Papillomavirus and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

Glycolytic inhibition by 3-bromopyruvate increases the cytotoxic effects of chloroethylnitrosoureas to human glioma cells and the DNA interstrand cross-links formation

脑胶质瘤中异柠檬酸脱氢酶突变及其抑制剂研究进展

Molecular mechanism of point mutation-induced Monopolar spindle 1 (Mps1/TTK) inhibitor resistance revealed by a comprehensive molecular modeling study

Structure‐based Discovery of Novel CK2α‐Binding Cyclic Peptides with Anti‐cancer Activity

IDO1天然小分子抑制剂的筛选及抗肿瘤作用研究

Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents

Synthesis and biological evaluation of novel steroidal 5α,8α-endoperoxide derivatives with aliphatic side-chain as potential anticancer agents

Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU

刺激响应型介孔二氧化硅纳米粒用于肿瘤诊断治疗研究进展

纳米凝胶载体系统的研究进展

聚合物药物结合物胶束在抗肿瘤药物递送方面的研究进展

纳米载体共递送化疗药物用于肿瘤联合治疗的研究进展

N-苯甲基靛红肟类JNK3抑制剂的分子对接及3D-QSAR研究(英文)

羧甲基壳聚糖作为药物载体的研究进展

靶向血管内皮生长因子及其受体的抗肿瘤药物研究进展

空间稳定免疫脂质体用于抗肿瘤药物载体的研究进展

Structural basis for decreased affinity of Emodin binding to Val66-mutated human CK2α as determined by molecular dynamics

阳离子固体脂质纳米粒/pDNA二元复合物的初步研究

蛋白多肽类药物非注射给药途径的研究

载鱼精蛋白-pDNA复合物固体脂质纳米粒的初步研究

核苷类抗癌、抗病毒靶向制剂的研究进展

托氟啶脂质体的研究

洛莫司汀热敏脂质体的制备及体外抗肿瘤活性研究

替莫唑胺固体脂质纳米粒在动物体内药动学及组织分布研究

SYBR Green Ⅰ-荧光法测定载鱼精蛋白缩合基因纳米粒中pDNA的含量和包封率

鱼精蛋白凝聚法测定脂质体和纳米脂质体包封率

肺靶向炎琥宁明胶微球的制备

人工神经网络结合药动学模型设计氯氮平非pH依赖型缓释片

麦胚凝集素修饰的胰岛素脂质体对小鼠口服吸收的促进作用

会议论文

基于药效团模型和分子对接的CK2抑制剂虚拟筛选

多重pH敏感靶向纳米载体用于抗肿瘤药物的逐级递送

研究方向