百晓学者学者目录

陈芬儿

博士生导师、教授，复旦大学

精选作品

期刊论文

2026

Ferrioxalate photocatalysis as a versatile system for reductive iron catalysis

Xiao Xiao, Lihao Liao, Pengbo Ren, Yunhua Ling, Zhuoyuan Ding, Fener Chen

Green Synthesis and Catalysis

DOI

2026

Total synthesis of γ-tocopherol via asymmetric 1,4-conjugate addition of alkyl Grignard reagents to 2-methyl chromone.

Ya-Ling Li, Yu'e Liu, Dong-Mei Yao, Jing-Dong Zhang, You-Cai Xiao, Fener Chen

Organic and biomolecular chemistry

DOI

2026

C-H Functionalization via Photo-and Electrochemistry in Flow: A Review

Bin Huang, M. Ke, Yajiao Zhang, Fener Chen

Organic Chemistry Frontiers

DOI

2026

From alpha to beta: a two-step strategy for stereoinversion of C16 glucocorticoids.

Jianhai Wei, Yajiao Zhang, Yuan Tao, Hangli He, Zhenhua Jia, Fener Chen

Organic and biomolecular chemistry

DOI

2026

Chemoenzymatic synthesis of mirabegron using an engineered styrene monooxygenase

Bingrong Chen, Saili Xu, Qi-Dong Pan, Rongchuan Hong, Wei Zhu, Xiaoxia Liu, M. Ke, Zhiran Ju, Fener Chen

Molecular Catalysis

DOI

2026

Development of pH-Resilient Boronic Acid ENPP1 Inhibitors for STING-Mediated Cancer Immunotherapy

Yaling Li, Meiling He, Jing-Dong Zhang, Ting Shi, Shan He, Ziqiang Chen, Chaowen Yang, Xiaomei Chen, Shuai Wang, You‐Cai Xiao, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2026

One‐Step Synthesis of Pd/HAP Precatalyst for 1,5‐Palladium Migration and C–H Silylation

Dongliang Zhang, Junrong Huang, Li Xiaochi, Ningxin Wang, Liaqat Ali, Yuexin Liu, Zhang Renrong, Nadeem Daniyal, Chen Wenyu, Yuxiang Zhu, Hengzhi You, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2026

Targeting the HIV-1 NNRTI Entrance Channel: Structure-Guided Optimization for Enhanced Safety and Selectivity

Yujie Zhang, Ling Dong, Yu-Ting Niu, Zhen-Zhu Lei, Qian Xu, Limin Zhao, Hao Deng, Christophe C. Pannecouque, Erik De Clercq, Phuong‐Thao Tran, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2026

Practical Catalytic Asymmetric Synthesis of Gem-Dimethyl Bicyclic [3.1.0] Proline: A Valuable Building Block for Antiviral Agents

Yangyang Zhong, M Zhang, M Li, Kehan Zhao, X. L. Hu, Huijing Wang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2026

Total Synthesis of (−)-Penibruguieramine A via an Intramolecular Aldol Reaction

Yaling Li, Xueyu Long, H Chen, Yijun Chen, Zhaowei Jiang, Pei Tang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2026

Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence

Kun Zhang, Yuhan Lin, Ling Dong, Yuting Niu, Jian Xun Peng, Christophe C. Pannecouque, Erik De Clercq, Phuong‐Thao Tran, Guobo Li, Tiancong Zhao, Xudong Li, Shuo Su, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2026

Metal hydride selection enables cross- and branched-selective hydroalkenylation

Xiao Xiao, Peng-Bo Ren, Lihao Liao, Chengjie Liu, Yunhua Ling, Fener Chen

Green Synthesis and Catalysis

DOI

2026

Iridium-Catalyzed Asymmetric Hydrogenation of Pyridazine Salts under Batch and Flow

Mengjuan Wu, Lei Yu, Hanlin Chen, Yuxin Lin, Liang Zhi-qian, Yaling Li, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2026

Kinetic Resolution of Racemic γ,γ-Disubstituted Cyclohexenones Enabled by Artificial Carboligase-Catalyzed Stereoselective Michael Addition

Li Zhang, Xueyan Yang, Xiaofan Wu, Miaolin Ke, Yuan Tao, Zedu Huang, Fen‐Er Chen

Organic Letters

DOI

2026

Machine-Learning-Guided Discovery and Engineering a Carbonyl Reductase for Efficient Stereoselective Synthesis of Chiral Aryl α-Fluoro β-Hydroxy Esters via Dynamic Kinetic Resolution

Xiaoping Yue, Qipeng Yan, Y Z Li, Jiale Wang, Jiale Wang, Xinyu Sun, Yuping Li, Qilin Gao, Jian‐bo Wang, Jian‐bo Wang, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2026

Amine Transaminase-Catalyzed Enantioselective Synthesis of Cyclohexylidene-Based Axially Chiral Amines

Haiyan Xu, Lin Yang, Li Zhang, Yueyue Ruan, Bo Liu, Chenguang Fan, Fuhui Zhou, Zedu Huang, Fen‐Er Chen

Organic Letters

DOI

2026

Unified Chemoenzymatic Approach to 16α-Methyl Glucocorticoids: Stereocontrolled Synthesis of (+)-Dexamethasone, (+)-Mometasone, (+)-Flumethasone, (+)-Halometasone, and (+)-Vamorolone

Hangli He, Yajiao Zhang, Minjie Liu, Menglan Li, Zedu Huang, Fen‐Er Chen

JACS Au

DOI

2026

Palladium-catalyzed branch-selective hydroamidation of alkynes: bypassing basicity barrier via a ligand-enabled proton transfer strategy

Ding Liu, Jiaxin Cheng, Yuan Tao, Jianai Chen, Jianai Chen, Yajiao Zhang, Xiao Xiao, Fen‐Er Chen

Molecular Catalysis

DOI

2026

Mn-catalyzed hydroxyalkylation of α-trifluoromethylstyrenes with cyclopropanols: facile synthesis of δ-trifluoromethyl-δ-hydroxyketones

Zhi-Xin Deng, Zhigang Liu, Jiyao Han, Tong-Yao Zhou, Dang Cheng, Xiao Xiao, Fen‐Er Chen

Green Chemistry

DOI

2026

7-Step flow synthesis of the anti-HBV nucleoside drug entecavir

Zhenzhen Wang, Yaling Li, Guo-Tai Zhang, Xianjing Zheng, Zhaowei Jiang, Pei Tang, Fen‐Er Chen

Green Chemistry

DOI

2026

The golden decade of eburnamine–vincamine alkaloid synthesis: 2015 to present

Huijing Wang, Jiayi Mu, Yangyang Zhong, Pei Tang, Fen‐Er Chen

Natural Product Reports

DOI

2026

From botanical origins to modern laboratories: 50 year journey in protoberberine alkaloid total synthesis

Weijian Li, Shuman Guan, Mingwei Li, Huijing Wang, Fen‐Er Chen

Natural Product Reports

DOI

2026

Flow Chemistry Enabled Asymmetric Total Synthesis of (+)-Biotin through Pseudocatalytic Strategy

Xianjing Zheng, Liang Gao, Yajiao Zhang, Jiale Wu, Dang Cheng, Li Qiang Wan, Fener Chen

JACS Au

DOI

2026

Asymmetric Iodoaminocyclization for the Synthesis of Chiral 2-Heteroaryl Pyrrolidines

Yangyang Zhong, Kehan Zhao, Kewen Zhong, Tianlan Zhao, Hongping Zhu, Huijing Wang, Fener Chen

Organic Letters

DOI

2026

Engineered Artificial Carboligase-Catalyzed Stereoselective Michael Addition of Nitroalkane to Cyclohexadienone

Li Zhang, Yanyan Sun, Xiaofan Wu, Qi Wang, Zhigang Liu, Yunyun Yang, Zedu Huang, Fener Chen

ACS Catalysis

DOI

2025

氘代-联苯-DAPYs衍生物作为高效低毒非核苷类逆转录酶抑制剂的设计、合成及抗HIV-1病毒活性研究

张坤，卜悦悦，Christophe Pannecouque，Erik De Clercq，Enzo Tramontano，Phuong-Thao Tran，王帅，陈芬儿

《药学学报》

2025

固定化羰基还原酶在连续流合成中的研究进展

胡畔，吴小凡，黄则度，陈芬儿

《中国医药工业杂志》

DOI

2025

Batch and continuous-flow asymmetric synthesis of d-pantothenic acid precursor enabled by immobilized ketoreductase mutant

Pan Hu, Xiaofan Wu, Yi An, Xianjing Zheng, Liang Gao, Yuan Tao, Yajiao Zhang, Zedu Huang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2025

基于环形离子淌度质谱的甾体立体异构体分析研究

程荡，桂娟，陈芬儿

《当代化工研究》

DOI

2025

微化工技术与流动化学课程案例教学探索与实践

程荡，陈芬儿

《化工高等教育》

2025

6-氨基嘌呤合成新工艺

汤芝平，苏蔚，郝文杰，陈芬儿

《当代化工》

2025

Liquid–solid mass transfer in micropacked bed reactors with immiscible liquid–liquid two-phase flow

Yanfu Chen, Yanfu Chen, Chu Zhou, Fen‐Er Chen, Fen‐Er Chen

Chinese Journal of Chemical Engineering

DOI

2025

Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents

B. Dong, Changlong Zheng, Huimeng Zhao, Shi-Peng Luo, Yihui Ou, Chenguang Liu, Fener Chen

Green Synthesis and Catalysis

DOI

2025

Visible light induced synthesis of the Benzoyl bioisosteres: bicyclo[1.1.1]pentane-ketone group

Jing Li, Yihui Ou, Xingyu Zhang, Xinru Li, Xin Liu, Chenguang Liu, Fener Chen

Green Synthesis and Catalysis

DOI

2025

Advances in benzaldehyde lyase-catalyzed biotransformations: from enzyme engineering to industrial applications

Zhiyun Li, Junwei Huang, Bingrong Chen, Shi-Long Dou, Xiaoxia Liu, Wei Zhu, Zhiran Ju, Fener Chen

Green Synthesis and Catalysis

DOI

2025

Metal–polyphenol network-based multifunctional materials for tumor therapy: Intrinsic properties, advances, and applications

Chen Ma, Qian Feng Xu, Ling‐Wen Ding, Xinya Liu, Junkai Cheng, Yiman Wang, Lu Liu, Jiaqi Xian, Jian Gu, Phuong‐Thao Tran, Qin Wang, Shuai Wang, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2025

Photoredox-Catalyzed Hydrofluoromethylthiolation of Unactivated Alkenes to Access Alkyl Di- and Trifluoromethyl Sulfides

Xiao-Qing Feng, Lili Zeng, Shi-Han Xu, Liang Shen, Xian Feng, Ronghui Huang, Fen‐Er Chen, Jian Han

The Journal of Organic Chemistry

DOI

2025

Synthesis of α-CF3-Substituted O-Heterocycles via Ligand-Controlled Cycloaddition of (E)-β-Trifluoromethylated Enones with π-Allylpalladium 1,4-Dipoles

Haoke Chu, Xiuxin Lv, Linhui Yang, Yue Chen, Junjie Zeng, Feng Xiao-qing, Hua‐Dong Xu, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2025

Bromo nitrile oxide-mediated disulfide formation and capping of N-terminal cysteine in peptides

Jingrong Huang, Xinhua Ding, Zihan Lin, Lin Yu, Yongqi Liao, Wang Gu, Fa‐Jie Chen, Fen‐Er Chen

Chinese Chemical Letters

DOI

2025

Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review

Shuwen Han, Xin Chen, Youting Yuan, Miaolin Ke, Dang Cheng, Jin‐Feng Hu, Liming Shao, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2025

Halogenation-Driven Discovery of Halomethylene-Biphenyl-Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Safety and PK Profiles

Xiaomei Chen, Qian Xu, Christophe C. Pannecouque, Erik De Clercq, Enzo Tramontano, Phuong‐Thao Tran, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2025

A concise asymmetric synthesis of (–)-oseltamivir phosphate via a biphasic Pd-catalyzed Heck-type cyclization

Qi Wang, Bichu Cheng, Minjie Liu, Fen‐Er Chen

Chinese Chemical Letters

DOI

2025

Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Xiaomei Chen, Qingqing Hao, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2025

Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review

Houzong Yao, Xianjing Zheng, Minjie Liu, Yuanyuan Xu, Ping Xu, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2025

Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors

Kun Zhang, Limin Zhao, Tianhao Xing, Yueyue Bu, Qingyun Wang, Christophe C. Pannecouque, Erik De Clercq, Angela Corona, Laura Dettori, Enzo Tramontano, Shuai Wang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2025

Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability

Kun Zhang, Tianhao Xing, Li Ding, Christophe C. Pannecouque, Erik De Clercq, Angela Corona, Laura Dettori, Enzo Tramontano, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2025

Development of Immobilized Chiral Iridium Catalysts by Strengthening Coordination Bonds for Z‐retentive Asymmetric Allylic Substitution

Junwen Wang, Zhen‐Chao Dong, Feng Liang, Yuxiang Zhu, Jiaying Liu, Junrong Huang, Hengzhi You, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2025

Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis

Xiao Xiao, Yu-Xia Jin, Zhi-Qing Wang, Lihao Liao, Peng-Bo Ren, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2025

Catalytic enantioselective total synthesis of antitubercular agents (–)-bedaquiline and (–)-sudapyridine enabled by dynamic kinetic resolution-asymmetric transfer hydrogenation

Jiyao Han, Dongliang Zhang, Yuan Tao, Pei Tang, Fen‐Er Chen

Chemical Science

DOI

2025

Enantioselective access to quaternary stereocenters of pyrrolidines via Rh-catalyzed intramolecular cyclization of 1,6-enynes

Runqi Hao, Fei Hou, Liqin Liu, Rao Wang, Yuan Tao, Zhenhua Jia, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2025

Highly regio- and diastereoselective construction of spirocyclic compounds via palladium-catalyzed [3 + 2] cycloaddition of vinyl methylene cyclic carbonates with pyrrolidinones

Huizhi Liu, Jiayi Zong, Boxuan Zhang, Jiahao Wang, Guohui Zheng, Miaolin Ke, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2025

Cobalt-Catalyzed Regioselective Hydroxyazidation of 1,3-Dienes: Direct Access to β-Azido Alcohols

Chi‐Fan Zhu, Xiaojing Li, Jun-Ju Mai, Jun-Yao Guan, Mingyuan Shi, Xiasen Dong, Fen‐Er Chen

Organic Letters

DOI

2025

Safety-Enhanced Multistep Flow Synthesis of Oxolinic Acid with Process Intensification

Changlong Zheng, Huimeng Zhao, Yihui Ou, Yongjiu Li, Peihao Zhang, Chenguang Liu, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2025

Molybdenum-catalyzed synthesis of 2,3-disubstituted indoles via imine condensation and C(sp 2 )–H insertion

Haoke Chu, Xiuxin Lv, Yitong Luo, Meiying Liu, Ronghui Huang, Xiao Feng, Fen‐Er Chen

Chemical Communications

DOI

2025

Sustainable and scalable three-step flow synthesis of metronidazole beyond batch limitations

Minjie Liu, Xianjing Zheng, Yajiao Zhang, Shufeng Li, Yingna Kong, Zhenzhu Lei, Li Qiang Wan, Fen‐Er Chen

Chemical Engineering Journal

DOI

2025

Unified Asymmetric Hydrogenation Enables Stereocontrolled Total Synthesis of Tacaman Alkaloids

Guodan Lin, Wen Zhang, Jie Liu, Shuangbo Huang, Yong Li, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2025

A New Chemo-Enzymatic Approach to Synthesize Isavuconazole Using an Engineered Benzaldehyde Lyase

Zhiyun Li, Saili Xu, Menglan Li, Wenhao Xu, Dang Cheng, Zhiran Ju, Fen‐Er Chen

Journal of Agricultural and Food Chemistry

DOI

2025

Dynamic pore engineering in COF-based nanozymes: Construction of hydrogen-bond-mediated confinement catalysis for enhanced asymmetric aldol reactions

Shizhao Wang, Qi Chen, Jiankang Li, Danni Lin, Ka Li, Chuangxin Dong, Xiao Xiao, Fen‐Er Chen

Chemical Engineering Journal

DOI

2025

Enhancing Reaction Compatibility in Telescoped Multistep Flow Synthesis via Hybridizing Micro Packed-Bed/Micro Tubing Reactors: Application to Cyproflanilide and Broflanilide

Xingyu Zhang, Gangqin Huang, Yihui Ou, Zeyi Luo, Zheyao Huang, Chenguang Liu, Fen‐Er Chen

JACS Au

DOI

2025

Light-Driven Reactions Catalyzed by Radical S-Adenosylmethionine Enzymes

He Li, Wei Ding, Fen‐Er Chen, Qi Zhang

ACS Catalysis

DOI

2025

Bioinspired Total Synthesis of (+)-α-Tocopherol

Jiaxin Cheng, Zhigang Liu, Ding Liu, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2025

Nitrite-Catalyzed Stereoselective Bromocyclization to Access Tetrahydrofuran Scaffolds under Batch and Flow: An Economic and Sustainable Approach to Gram-Scale Total Synthesis of Posaconazole

Xiao Xiao, Jun-Bo Zheng, Yu-Xia Jin, Peng-Bo Ren, Haibo Jiang, Lihao Liao, Min Wang, Zhi-Qing Wang, Dang Cheng, Fen‐Er Chen

Organic Letters

DOI

2025

Enantioselective Synthesis of N–N Indole-Pyrrole Atropisomers via Palladium/Chiral Phosphonic Acid Relay Catalysis

Dayuan Wang, Jiayi Zong, Boxuan Zhang, Jiahao Wang, Bowen Wang, Hu‐Ri Piao, Dang Cheng, Jinfei Lin, Zhiran Ju, Miaolin Ke, Fen‐Er Chen

ACS Catalysis

DOI

2025

Enantioselective Synthesis of Fused Bicyclic Cyclohexadienes by Rh/Si-SDP-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Diynes with Acrylamides or Enamides

Fei Hou, Zhigang Liu, Tong-Yao Zhou, Minjie Liu, Yuan Tao, Yajiao Zhang, Fa‐Jie Chen, Fen‐Er Chen

ACS Catalysis

DOI

2025

Enantiocomplementary Access to Silicon-Stereogenic Silacyclohexenones via Ene-Reductase-Catalyzed Desymmetrization of Silacyclohexadienones

Xiaofan Wu, Fei Hou, Li Zhang, Qiong Wu, Zedu Huang, Fen‐Er Chen

ACS Catalysis

DOI

2025

Total Synthesis of (+)-Leucolusine and (−)-7-epi-Leucolusine

Han Chen, Yaling Li, Lei Yu, Xiaomei Hu, Huijing Wang, Qiantao Wang, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2025

Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors

Yiying Zhang, Rao Wang, Yueyue Bu, Angela Corona, Laura Dettori, Enzo Tramontano, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Ge Meng, Fen‐Er Chen

Molecules

DOI

2025

Sustainable and Integrated Flow-Based Three-Step Synthesis of Sodium Valproate

Minjie Liu, Hang Zhao, Yajiao Zhang, Dang Cheng, Li Qiang Wan, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2025

A highly efficient immobilization strategy for chiral ferrocene P, P-ligands with enhanced performance in asymmetric catalysis

Chao Wang, Jingyuan Liao, Ana Xu, Yuxiang Zhu, Junrong Huang, Hengzhi You, Fen‐Er Chen

Journal of Catalysis

DOI

2025

Continuous flow synthesis of (E)-O-(3-chloro-2-propenyl)hydroxylamine: a key intermediate of clethodim

Chengxia Tan, Yang Chen, Junhui Wu, Mimi Li, Dang Cheng, Miaolin Ke, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2025

Continuous-flow synthesis of prenyl chloride on-demand through surface-mediated hydrochlorination

Hang Zhao, Xiao Xiao, Runqi Hao, Dan Chen, Jiawei Ke, Minjie Liu, Li Wan, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2025

Flow chemistry-enabled asymmetric synthesis of cyproterone acetate in a chemo-biocatalytic approach

Yajiao Zhang, Minjie Liu, Xianjing Zheng, Liang Gao, Wan Li, Dang Cheng, Fen‐Er Chen

Nature Communications

DOI

2025

Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase

Yitong Li, Yunyun Yang, Mengting Zhang, Xiaoping Yue, Rey‐Ting Guo, Zedu Huang, Fen‐Er Chen

ACS Catalysis

DOI

2025

Nucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors

Wei Wang, Yuanyuan Peng, Yang Liu, Yanchun Lin, Fei Zhao, Qinlin Chen, Liangming Xuan, Qiongjiao Yan, Fen‐Er Chen, Hui Zhou

Nature Communications

DOI

2025

Enantioselective [5 + 1] cycloaddition of sulfur ylides and vinylethylene carbonates via synergistic palladium/chiral phosphonic acid catalysis

Miaolin Ke, Jinying Zheng, Jiayi Zong, Keshuang Tang, Jiahao Wang, Guohui Zheng, Boxuan Zhang, Dang Cheng, Zhiran Ju, Fen‐Er Chen

Chemical Science

DOI

2025

Pd-catalyzed asymmetric allylic alkylation of N -hydroxyphthalimide esters with allyl acetates

Yixuan Zheng, Xinhao Deng, Fei Zhao, Yuanyuan Peng, Qiongjiao Yan, Wei Wang, Fen‐Er Chen, Hui Zhou

Organic Chemistry Frontiers

DOI

2025

Stereodivergent access to α- and β-azanucleosides via catalyst-free, achiral modulator-controlled iodocyclization: a concise synthesis of forodesine

Yangyang Zhong, Jie Zeng, Mingwei Li, Yuli Liang, Shuman Guan, Kehan Zhao, Jiayi Mu, Pei Tang, Huijing Wang, Fener Chen

Chemical Science

DOI

2024

基于甘氨酸衍生物α-C（sp3）—H官能团化的催化体系研究进展

宣良明，赵伟，范润东，严琼姣，汪伟，陈芬儿

《有机化学》

2024

无过渡金属或无光催化剂条件下可见光促进喹喔啉酮C(3)—H官能团化研究进展

董江湖，宣良明，王池，赵晨熙，王海峰，严琼姣，汪伟，陈芬儿

《有机化学》

2024

抗病毒药物化学研究新进展

展鹏，陈芬儿

《药学进展》

2024

全连续流反应技术在药物合成中的新进展(2019～2022)

冯康博，陈炯，古双喜，王海峰，陈芬儿

《有机化学》

2024

Cu-catalyzed three-component C S P coupling for the synthesis of trisubstituted allenyl phosphorothioates

Bowen Wang, Bowen Wang, Longwu Sun, Qianqian Cao, Xinzhi Li, Jianai Chen, Jianai Chen, Shizhao Wang, Miaolin Ke, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

Stereodivergent Total Synthesis of Tacaman Alkaloids.

Xiangtao Chen, Hui-Jing Wang, Jie Zeng, Qiuhong Li, Tonghui Zhang, Qiaoyun Yang, Pei Tang, Fener Chen

Angewandte Chemie

DOI

2024

Synthesis of 2,4-Disubstituted Oxazoles and Thiazoles via Brønsted Acid-Catalyzed Cyclization of α-diazoketones with Amides.

Meng-Xiang Luo, Lewan Li, Shixin Chen, Qiong-Jiao Yan, Jian Lv, Jie Zeng, Hai-Feng Wang, Shuangxi Gu, Fener Chen

Journal of Organic Chemistry

DOI

2024

Structural modification based on the diclofenac scaffold: Achieving reduced colitis side effects through COX-2/NLRP3 selective inhibition.

Zhiran Ju, Junde Xu, Keshuang Tang, Fener Chen

European journal of medicinal chemistry

DOI

2024

Recent Advances in Visible-Light-Induced C(3)—H Functionalization of Quinoxalinones under Transition-Metal-Free or Photocatalyst-Free

Jianghu Dong, Liangming Xuan, Chi Wang, Chenxi Zhao, Hai-Feng Wang, Qiong-Jiao Yan, Wei Wang, Fener Chen

Youji huaxue

DOI

2024

Visible light-promoted C3-H alkoxycarbonylation of quinoxalin-2(1H)-ones or coumarins with alkyloxalyl chlorides.

Yanchun Lin, Xi Zhou, Yixuan Zheng, Bingran Chen, Yang Liu, Yi Zhang, Qiong-Jiao Yan, Wei Wang, Fener Chen

Organic and biomolecular chemistry

DOI

2024

Synthesis of Deoxy Pyranosides via Fe(III) Catalyzed Regioselective Thiocarbonylation of Partially Protected Carbohydrates

Jie Zhao, Xiaorui Zhang, Qichang Yang, Hai-Feng Wang, Shuangxi Gu, Qiong-Jiao Yan, Jian Lv, Fener Chen

Annalen der Pharmacie

DOI

2024

Solvent‐Directed Regioselective Cascade Reaction with Diazo Compounds

Menghua Dong, Chunan Wang, Lewan Li, Yufan Chen, Jie Zeng, Jian Lv, Jie Liao, Hai-Feng Wang, Shuangxi Gu, Fener Chen

Annalen der Pharmacie

DOI

2024

Visible-light-induced tandem ring opening/1,6-conjugate addition of cyclobutanols with p-quinone methides under metal- and additive-free conditions

Tongyao Zhou, Jie Zeng, Yang Liu, Hang Chen, Hai-Feng Wang, Qiong-Jiao Yan, Wei Wang, Fener Chen

Green Chemistry

DOI

2024

Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid

Pan Hu, Xiao-Fan Wu, Yajiao Zhang, Minjie Liu, Yuan Tao, Ze-Du Huang, Fener Chen

Green Chemistry

DOI

2024

Recent Advances of the Catalysis Systems in the α-C(sp3)—H Functionalization of Glycine Derivatives

Liangming Xuan, Wei Zhao, Rundong Fan, Qiong-Jiao Yan, Wei Wang, Fener Chen

Youji huaxue

DOI

2024

New Progress of Fully Continuous Flow Reaction Technologies in Pharmaceutical Synthesis (2019~2022)

Kangbo Feng, Jiong Chen, Shuangxi Gu, Hai-Feng Wang, Fener Chen

Youji huaxue

DOI

2024

Visible-light-driven selective difluoroalkylation of α-CF3 alkenes to access CF2-containing gem-difluoroalkenes and trifluoromethylalkanes

Panpan Lei, Bingran Chen, Tonghui Zhang, Qinlin Chen, Liangming Xuan, Hai-Feng Wang, Qiongjiao Yan, Wei Wang, Jie Zeng, Fener Chen

Organic Chemistry Frontiers

DOI

2024

Regioselective Cleavage and Reconfiguration of C-S Bonds with Diazo Compounds.

Huan Li, Zhi-Min Xia, Lewan Li, Jie Zeng, Jian Lv, Hai-Feng Wang, Shuangxi Gu, Fener Chen

Organic Letters

DOI

2024

Diversification of 3′‐Amino Nucleosides via Enzymatic Transglycosylation

Li Zhang, Haiyan Xu, Xiao-Fan Wu, Yi-Tong Li, Yuan Tao, Ze-Du Huang, Fener Chen

ChemCatChem

DOI

2024

Green Synthesis of Alzheimer's Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis.

Yongjiu Li, Xin Liu, Qiong Liu, Yuchen Wang, Fener Chen, Chenguang Liu

ChemSusChem

DOI

2024

Structural modification of natural axinelline A: Achieving reduced colitis side effects through balanced COX inhibition.

Zhiran Ju, Ziyi Shang, Yong-Hong Liu, Shihai Xu, Jingjie Fang, Fener Chen

Bioorganic chemistry (Print)

DOI

2024

Visible-Light-Induced Markovnikov Hydroalkoxylation of α-Trifluoromethyl Alkenes with ortho-Diketones

Qinlin Chen, Rundong Fan, Xinhao Deng, Jinxiu Chen, Wei Wang, Qiongjiao Yan, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2024

A modified Bis-OPNN phosphorus ligand for Rh-catalyzed linear-selective hydroformylation of alkenes

Luyun Zhang, Ding Liu, Hu‐Ri Piao, Zhenhua Jia, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines

Wenjuan Huang, Christophe C. Pannecouque, Erik De Clercq, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2024

Cell-Based Screen Identifies a Highly Potent and Orally Available ABCB1 Modulator for Treatment of Multidrug Resistance

Shuai Wang, Shuai Wang, Sai-Qi Wang, Sai-Qi Wang, Xiaobing Chen, Qian Xu, Hao Deng, Qiu‐Xu Teng, Zhe‐Sheng Chen, Xuyao Zhang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2024

Fragment Addition-Based Design of Heteroaromatic-Biphenyl-DAPYs as Potent and Orally Available Non-nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Enhanced Safety

Wenjuan Huang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2024

Asymmetric conjugated addition of aryl Grignard reagents for the construction of chromanones bearing quaternary stereogenic centers in batch and flow

Yaling Li, Jia-Wei Ke, Yue Liu, Dong-Mei Yao, Jingdong Zhang, You‐Cai Xiao, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

Advances of Ugi reaction in natural product synthesis

Wen Zhang, Pei Tang, Mohamed Aamer Abubaker, Guo‐Hua Hu, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2024

Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance

Kun Zhang, Yujie Zhang, Min Li, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Medicinal Research Reviews

DOI

2024

A spirosilane ligand induced highly enantioselective Rh-catalyzed cycloisomerization of 1,6-enynes

Zequn Tan, Fei Hou, Jie Zeng, Fan Yang, Tongyao Zhou, Guo‐Hua Hu, Yajiao Zhang, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2024

Structure-based discovery of novel piperidine-biphenyl-DAPY derivatives as non-nucleoside reverse transcriptase inhibitors featuring improved potency, safety, and selectivity: From piperazine-biphenyl-DAPYs to piperidine-biphenyl-DAPYs

Wenjuan Huang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2024

A Radical Activation Strategy for Versatile and Stereoselective N‐Glycosylation

Wenyan Ding, Xinyu Chen, Zuyao Sun, Jiaxin Luo, Shiping Wang, Qingqing Lu, Jialu Ma, Chongxin Zhao, Fen‐Er Chen, Chunfa Xu

Angewandte Chemie

DOI

2024

Asymmetric synthesis of allylic sulfonamides with axially and central chirality via palladium-catalyzed of atroposelective N-allylic alkylation

Dayuan Wang, Jiayi Zong, Bowen Wang, Longwu Sun, Xiao Xiao, Hu‐Ri Piao, Miaolin Ke, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2024

Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis of α-substituted amides in flow

Hua‐Shan Huang, Jingze Chen, Luyun Zhang, Hong Yan, Siqi Li, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

Palladium-catalyzed tandem aza-Heck reaction of alkene-tethered oxime esters with cyclopropanols

Kangning Cao, Shutao Qi, Jianhui Li, Wenshao Ye, Junfeng Yang, Junliang Zhang, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2024

Transition metal-free tunable synthesis of 3-(trifluoromethylthio) and 3-trifluoromethylsulfinyl chromones via domino C H functionalization and chromone annulation of enaminones

Tao Zhou, Jing Zhou, Yunyun Liu, Jie‐Ping Wan, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

Recent advances in remote C(sp3)–H functionalization via chelating group-assisted metal-catalyzed chain-walking reaction

Jian Han, Lili Zeng, Qin-Yu Fei, Yan-Xiang Ge, Ronghui Huang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2024

One-Pot Chemoenzymatic Synthesis of Arsinothricin and the Mechanistic Insights into the Noncanonical Radical SAM Enzyme ArsL

Li He, Fen‐Er Chen, Wei Ding, Qi Zhang

ACS Catalysis

DOI

2024

Asymmetric Synthesis of Chiral Benzoins Enabled by Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Benzils

Yangtian Ye, Yuan Tao, Pan Hu, Yajiao Zhang, Li Zhang, Xiaofan Wu, Zedu Huang, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2024

Enantioselective Aminosilylation of Alkenes by Palladium/Ming‐Phos‐Catalyzed Tandem Narasaka–Heck/Silylation Reaction

Kangning Cao, Jie Han, Wenshao Ye, Dejun Hu, Zihao Ye, Junfeng Yang, Junliang Zhang, Fen‐Er Chen

Advanced Science

DOI

2024

Desymmetrization of Inert meso-Diethers through Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents

Jun Li, Yu Wang, Yan Wang, Lianjie Zhai, Junrong Huang, Lijuan Song, Hengzhi You, Fen‐Er Chen

Organic Letters

DOI

2024

Photoswitched Stereodivergent Synthesis of Allylic Sulfones

Hua‐Shan Huang, Liuhui Xu, Chun-Mei Zhang, Changwu Cheng, Zhi Chai, Hong Yan, Fen‐Er Chen

Organic Letters

DOI

2024

Asymmetric Total Synthesis of Anti-HBV Drug Entecavir: Catalytic Strategies for the Stereospecific Construction of Densely Substituted Cyclopentene Cores

Guo-Tai Zhang, Gen Li, Lin‐Xi Wan, Xinxin Pu, Junhai Chang, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2024

Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors

Kexin Zhao, Yiying Zhang, Jin-Si Wang, Shuai Wang, Shuai Wang, Shuai Wang, Angela Corona, Stefania Maloccu, Enzo Tramontano, Christophe C. Pannecouque, Erik De Clercq, Ge Meng, Lei Wang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2024

Amplifying enantioselectivity in asymmetric transformations using heterogeneous chiral single-rhodium-site catalyst with sustained catalytic activity

Junwen Wang, Feng Liang, Junrong Huang, Jun Li, Jingyuan Liao, Chengyao Zhao, Hengzhi You, Tao Tu, Fen‐Er Chen

Chemical Engineering Journal

DOI

2024

Scalable and Integrated Four-step Continuous-Flow Synthesis of Ibuprofen Using a Zinc-Catalyzed 1,2-Aryl Migration Strategy

Qiao Li, Minjie Liu, Yajiao Zhang, Li Qiang Wan, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2024

Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy

Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe C. Pannecouque, Erik De Clercq, Ge Meng, Fen‐Er Chen

Molecules

DOI

2024

P(V)-Promoted Rh-Catalyzed Highly Regioselective Hydroformylation of Styrenes under Mild Conditions

Tong Ru, Yajiao Zhang, Qiuxiang Wei, Sheng Zuo, Zhenhua Jia, Fen‐Er Chen

Molecules

DOI

2024

Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters

Xiaofan Wu, Lin Yang, Zhigang Liu, Ke Zhang, Zedu Huang, Fen‐Er Chen

ACS Catalysis

DOI

2024

Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility

Jin-Si Wang, Jin-Si Wang, Kun Zhang, Kun Zhang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2024

Non-symmetric stapling of native peptides

Fa‐Jie Chen, Wanzhen Lin, Fen‐Er Chen

Nature Reviews Chemistry

DOI

2024

Pd-Catalyzed Asymmetric Aza-Heck Cyclization/Sonogashira Reaction of Alkene-Tethered Oxime Esters and Alkynes

Kangning Cao, Jie Han, Haichao Shen, Junfeng Yang, Junliang Zhang, Fen‐Er Chen

ACS Catalysis

DOI

2024

Enantioselective synthesis of vicinal diols by an enzymatic approach

Zhiran Ju, Menglan Li, Fen‐Er Chen

Molecular Catalysis

DOI

2024

Copper-Catalyzed Asymmetric Remote C(sp3)–H Alkylation of N-Fluorocarboxamides with Glycine Derivatives and Peptides

Wei Wang, Liangming Xuan, Qinlin Chen, Rundong Fan, Fei Zhao, Jianghu Dong, Haifeng Wang, Qiongjiao Yan, Hui Zhou, Fen‐Er Chen

Journal of the American Chemical Society

DOI

2024

Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow

Heng Pang, Junrong Huang, Juntao Wang, Gang Wang, Ana Xu, Lei Luo, Qunhui Yuan, Hengzhi You, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2024

Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers via Synergistic Pd/Cu Catalysis

Miaolin Ke, Xinzhi Li, Jiayi Zong, Bowen Wang, Jinying Zheng, Shujia Zhang, Jian-Ai Chen, Fen‐Er Chen

Organic Letters

DOI

2024

Copper-catalyzed asymmetric allylic substitution of racemic/ meso substrates

Jun Li, Junrong Huang, Yan Wang, Yuexin Liu, Yuxiang Zhu, Hengzhi You, Fen‐Er Chen

Chemical Science

DOI

2024

Recent advances in the total synthesis of galantamine, a natural medicine for Alzheimer's disease

Bichu Cheng, Qi Wang, Yi An, Fen‐Er Chen

Natural Product Reports

DOI

2024

Highly enantioselective synthesis of both enantiomers of tetrahydroquinoxaline derivatives via Ir-catalyzed asymmetric hydrogenation

Ana Xu, Lanxing Ren, Junrong Huang, Yuxiang Zhu, Gang Wang, Chaoyi Li, Yongqiang Sun, Lijuan Song, Hengzhi You, Fen‐Er Chen

Chemical Science

DOI

2024

Green solvent mixture for ultrasound-assisted solid-phase peptide synthesis: a fast and versatile method and its applications in flow and natural product synthesis

Jingyuan Liao, Renrong Zhang, Xuelei Jia, Meiling Wang, Chaoyi Li, Juntao Wang, Ren‐Jin Tang, Junrong Huang, Hengzhi You, Fen‐Er Chen

Green Chemistry

DOI

2024

Recyclable picolinamide-derived ligand-controlled branched-selective hydroesterification of alkynes with alcohols and phenols

Ding Liu, Luyun Zhang, Jiaxin Cheng, Qiuxiang Wei, Zhenhua Jia, Fen‐Er Chen

Green Chemistry

DOI

2024

Four-step continuous-flow total synthesis of (−)-debromoflustramine B using a chiral heterogeneous Pd NP catalyst

Junwen Wang, Feng Liang, Zhen‐Chao Dong, Junrong Huang, Yuxiang Zhu, Hengzhi You, Fen‐Er Chen

Chemical Science

DOI

2024

Highly enantio- and diastereoselective construction of spirocyclic oxindoles via a palladium-catalyzed decarboxylative asymmetric [4 + 2] annulation strategy

Pengyuan You, Minjie Liu, Ke Zhang, Fan Yang, Zequn Tan, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2024

Asymmetric palladium-catalyzed decarboxylative [3 + 2] cycloaddition: straightforward construction of chiral spiro-heterocyclic scaffolds

Ke Zhang, Pengyuan You, Sheng Zuo, Yuan Tao, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2024

Organocatalytic formal [4 + 2] cycloaddition of o -quinone-methyl derivatives and 2-isocyanatomalonate diesters for the construction of chroman derivatives with adjacent quaternary chiral centers

Tong Xiong, Yi-Zhao Xu, Yao Wang, You‐Cai Xiao, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2024

Sustainable synthesis of long-acting local anesthetics ropivacaine and levobupivacaine under batch and continuous flow via asymmetric hydrogenation

Zhi Yang, Hanlin Chen, Linxi Wan, Xinyi Feng, Lingshuang Ma, Pei Song Tang, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2024

Iridium-catalyzed asymmetric hydrogenation of 5-hydroxypicolinate pyridinium salts under batch and flow: stereodefined access to cis -configurated hydroxypiperidine esters

Zhi Gang Yang, Shangxian Luan, Lin‐Xi Wan, Jingxi Chen, Xiaofang Wei, Pei Tang, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2024

Ketoreductase-catalyzed dynamic reductive kinetic resolution of sterically hindered 2-aryl-1,5-benzothiazepin-3,4(2 H ,5 H )-diones: asymmetric synthesis of a key diltiazem precursor and its analogues

Zijun Guo, Zexin Wu, Xiaofan Wu, Li Zhang, Zedu Huang, Fen‐Er Chen

Green Chemistry

DOI

2024

Stereoselective reduction of diarylmethanones via a ketoreductase@metal–organic framework

Zexin Wu, Yangtian Ye, Zijun Guo, Xiaofan Wu, Li Zhang, Zedu Huang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2024

Selective C–H functionalizations of arenes catalyzed by poly NHC–Pd in flow

Shiqi Huang, Runqi Hao, Qiao Li, Li Wan, Fen‐Er Chen

Reaction Chemistry & Engineering

DOI

2024

Correction: Cu-catalyzed arylation of S -tosyl peptides with arylboronic acids

Junjie Ying, Jingrong Huang, Chenguang Liu, Fa‐Jie Chen, Chunfa Xu, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2024

Rational redesign of the loop dynamics of carbonyl reductase LfSDR1 to improve the stereoselectivity for asymmetric synthesis of bulky chiral alcohols

Xiaoping Yue, Yitong Li, Man-Kun Wei, Yu Duan, Lin Yang, Fener Chen

International Journal of Biological Macromolecules

DOI

2023

可见光促进N-氟代酰胺的1,5-氢迁移和自由基偶联反应合成联苄基衍生物

雷盼盼，陈沁琳，陈航，周洋，敬林海，汪伟，陈芬儿

《有机化学》

2023

可见光氧化还原催化炔基化反应的研究进展

归春明，周潼瑶，王海峰，严琼姣，汪伟，黄锦，陈芬儿

《有机化学》

2023

α-氰醇甲磺酸酯与丙二酸酯的亲核取代反应合成α-芳基腈类化合物

王雷刚，郑逸轩，周希，王海峰，严琼姣，汪伟，陈芬儿

《有机化学》

2023

Asymmetric synthesis of syn-aryl-(2S,3R)-2-chloro-3-hydroxy esters via an engineered ketoreductase-catalyzed dynamic reductive kinetic resolution

Xiaoping Yue, Yitong Li, Di Sang, Yuan Tao, Zedu Huang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2023

瑞德西韦核碱基单元的连续流合成（英文）

郭永兴，刘敏杰，姜梅芬，陶媛，程荡，陈芬儿

Engineering

2023

TfOH‐Catalyzed Regioselective Alkylation of Hydroxybenzotriazole with Diazo Compounds and Further Base‐facilitated Elimination under Batch and Flow Conditions

Meng-Xiang Luo, Rui Wang, Yang Li, Jiahao Gong, Shuangxi Gu, Qiongjiao Yan, Jian Lv, Jie Zeng, Wei Wang, Hai-Feng Wang, Fener Chen

Asian Journal of Organic Chemistry

DOI

2023

Divergent Chemo- and Biocatalytic Route to 16β-Methylcorticoids: Asymmetric Synthesis of Betamethasone Dipropionate, Clobetasol Propionate, and Beclomethasone Dipropionate.

Jianhai Wei, Yajiao Zhang, Minjie Liu, Yi Ning, Yi-Ran Cao, Fener Chen

Angewandte Chemie

DOI

2023

Recent Advances in Visible Light Photoredox-Catalyzed Alkynylation

Chunming Gui, Tongyao Zhou, Haifeng Wang, Qiongjiao Yan, W. Wang, Jin Huang, Fener Chen

Youji huaxue

DOI

2023

Syntheses of Substituted α,β-Unsaturated δ-Lactams from N-Boc-2,4-dioxopiperidine

Saiya Liu, Chenchen Zhang, Qihua Xiong, Yuexin Liu, Lu Li, Yongqiang Sun, Bichu Cheng, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2023

Nitrite-catalyzed economic and sustainable bromocyclization of tryptamines/tryptophols to access hexahydropyrrolo[2,3-b]indoles/tetrahydrofuroindolines in batch and flow

Xiao Xiao, Biao Chen, Jiawei Li, Junbo Zheng, Xu Wang, Hang Zhao, Fen‐Er Chen

Chinese Chemical Letters

DOI

2023

Insight from Linker Investigations: Discovery of a Novel Phenylbenzothiazole Necroptosis Inhibitor Targeting Receptor-Interacting Protein Kinase 1 (RIPK1) from a Phenoxybenzothiazole Compound with Dual RIPK1/3 Targeting Activity

Jingjie Fang, Houzong Yao, Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2023

A Chemo-Enzymatic Approach for Preparing Efinaconazole with High Optical Yield

Zhiran Ju, Zhiyun Li, Menglan Li, Saili Xu, Kumaravel Kaliaperumal, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2023

Palladium-catalyzed stereoselective decarboxylative [4 + 2] cyclization of 2-methylidenetrimethylene carbonates with pyrrolidone-derived enones: Straightforward access to chiral tetrahydropyran-fused spiro-pyrrolidine-2,3-diones

Ke Zhang, Sheng Zuo, Pengyuan You, Tong Ru, Fen‐Er Chen

Chinese Chemical Letters

DOI

2023

Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility

Limin Zhao, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2023

Photo-induced 1,2-aryl migration of 2-chloro-1-arylpropanone under batch and flow conditions: Rapid, scalable and sustainable approach to 2-arylpropionic acids

Qiao Li, Minjie Liu, Meifen Jiang, Wan Li, Yingtang Ning, Fen‐Er Chen

Chinese Chemical Letters

DOI

2023

Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy

Ya-Li Sang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2023

Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability

Ya-Li Sang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2023

TfOH-Catalyzed Regioselective S–H Insertion of Cyclic Thioamide Derivatives with Diazo Compounds at Room Temperature

Chunyan Li, Rui Wang, Li Huang, Jiale Chen, Jingru Jin, Qiongjiao Yan, Wei Wang, Haifeng Wang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2023

Organocatalytic Asymmetric Morita–Baylis–Hillman Reaction of Isatins with Vinyl Sulfones

Hong‐Jiao He, Ruiqi Wang, Lin‐Xi Wan, Liyan Zhou, Hongyan Li, Guo‐Bo Li, You‐Cai Xiao, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2023

Iridium-catalyzed asymmetric, complete hydrogenation of pyrimidinium salts under batch and flow

Zhi Gang Yang, Yu Chen, Lin‐Xi Wan, Yuxiao Li, Dan Chen, Jianlin Tao, Pei Tang, Fen‐Er Chen

Green Chemistry

DOI

2023

Sustainable asymmetric synthesis of diltiazem precursor enabled by recombinant Escherichia coli whole cells co‐expressing an engineered ketoreductase and glucose dehydrogenase

Xiaoping Yue, Yitong Li, Lin Yang, Di Sang, Zedu Huang, Fen‐Er Chen

Biotechnology Journal

DOI

2023

Panaxadiol carbamate derivatives: Synthesis and biological evaluation as potential multifunctional anti-Alzheimer agents

Yuan Quan, Xiaoting Li, Lei Pang, Hao Deng, Fen‐Er Chen, Jung Joon Lee, Zhe‐Shan Quan, Peng Liu, Hongyan Guo, Qing‐Kun Shen

Bioorganic Chemistry

DOI

2023

Visible-Light-Driven C,N -Selective Heteroarylation of N -Fluoroalkyl Hydroxylamine Reagents with Quinoxalin-2(1 H )-ones

Yang Liu, Tongyao Zhou, Liangming Xuan, Yanchun Lin, Fuqi Li, Haifeng Wang, Jian Lyu, Qiongjiao Yan, Hui Zhou, Wei Wang, Fen‐Er Chen

Organic Letters

DOI

2023

The vinyl sulfone motif as a structural unit for novel drug design and discovery

You‐Cai Xiao, Fen‐Er Chen

Expert Opinion on Drug Discovery

DOI

2023

Visible-Light-Induced Defluorinative α-C(sp3)–H Alkylation for the Synthesis of gem-Difluoroallylated α-Trifluoromethylamines

Bingran Chen, Qinlin Chen, Yang Liu, Jinxiu Chen, Xi Zhou, Haifeng Wang, Qiongjiao Yan, Wei Wang, Zeyu Cai, Fen‐Er Chen

Organic Letters

DOI

2023

Cu-catalyzed arylation of S -tosyl peptides with arylboronic acids

Junjie Ying, Jingrong Huang, Chenguang Liu, Fa‐Jie Chen, Chunfa Xu, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2023

Rhodium-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes Enabled by Spirosiladiphosphine Ligands: Constructing Chiral Five-Membered Rings with a Boron Handle

Fei Hou, Yingtang Ning, Lili Song, Zequn Tan, Jiawen Yang, Zhigang Liu, Fen‐Er Chen

Organic Letters

DOI

2023

Cu-Catalyzed Intermolecular Asymmetric Propargylic Substitution of N-Hydroxyphthalimide Esters with Propargyl Carbonates

Chunming Gui, Yuanyuan Peng, Yang Zhou, Yixuan Zheng, Haifeng Wang, Qiongjiao Yan, Hui Zhou, Wei Wang, Fen‐Er Chen

ACS Catalysis

DOI

2023

Huperzine alkaloids: forty years of total syntheses

Bichu Cheng, Lili Song, Fen‐Er Chen

Natural Product Reports

DOI

2023

Design of Balanced Cyclooxygenase Inhibitors Based on Natural Anti‐inflammatory Ascidian Metabolites and Celecoxib

Jingjie Fang, Ziyi Shang, Kumaravel Kaliaperumal, Zhiran Ju, Fen‐Er Chen

ChemMedChem

DOI

2023

Substrate-Controlled Catalysis in the Ether Cross-Link-Forming Radical SAM Enzymes

Suze Ma, Wenhui Xi, Shu Wang, Heng Chen, Sijia Guo, Tianlu Mo, Wenxue Chen, Zixin Deng, Fen‐Er Chen, Wei Ding, Qi Zhang

Journal of the American Chemical Society

DOI

2023

Scalable and Sustainable Synthesis of Calcium Dobesilate via Integrated Five-Step Continuous-Flow Chemistry

Minjie Liu, Li Qiang Wan, Liang Gao, Dang Cheng, Meifen Jiang, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2023

Sulfonate-Modified Picolinamide Diphosphine: A Ligand for Room-Temperature Palladium-Catalyzed Hydrocarboxylation in Water with High Branched Selectivity

Ding Liu, Tong Ru, Zhixin Deng, Luyun Zhang, Yingtang Ning, Fen‐Er Chen

ACS Catalysis

DOI

2023

Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs

Ruo-Lan Zhou, Chao Yu, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2023

Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I

Ruo-Lan Zhou, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2023

Chemodivergent Synthesis of Sulfonamide and Sulfones from N-Tosylhydrazones by Switching Catalyst and Temperature

Jingru Jin, Chunyan Li, Rui Wang, Zhimin Xia, Qiongjiao Yan, Wei Wang, Shuang‐Xi Gu, Haifeng Wang, Fen‐Er Chen

Organic Letters

DOI

2023

A Robust Copper-Catalyzed Cross-Coupling of Glycosyl Thiosulfonate and Boronic Acids Enables the Construction of Thioglycosides

Zuyao Sun, Weitao Yan, Lihuang Xie, Wenchao Liu, Chunfa Xu, Fen‐Er Chen

Organic Letters

DOI

2023

Continuous-flow synthesis of 7-methoxy-1-tetralone: an important intermediate of (-)-Dezocine

Liangchuan Lai, Liang Gao, Minjie Liu, Yongxing Guo, Dang Cheng, Meifen Jiang, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2023

On-the-fly H2 degassing: Towards selective borohydride reduction of α, β-unsaturated esters to allylic alcohols in continuous microflow

Jiale Wu, Yuan Tao, Dang Cheng, Fen‐Er Chen

Chemical Engineering Science

DOI

2023

An Eight-Step Continuous-Flow Total Synthesis of Vitamin B1

Meifen Jiang, Minjie Liu, Weijian Li, Ying‐Qi Xia, Fen‐Er Chen

Engineering

DOI

2023

Recyclable Silica-Support Taniaphos/Copper(Ⅰ) complex for asymmetric allylic alkylation reactions

Chao Wang, Yan Wang, Xuelei Jia, Junrong Huang, Hengzhi You, Fen‐Er Chen

Journal of Catalysis

DOI

2023

Development of an Inline Tube-in-Tube Solvent Exchanger for Continuous-Flow Swap from High- to Low-Boiling Solvent

Jiale Wu, Xianjing Zheng, Li Qiang Wan, Yuan Tao, Dang Cheng, Fen‐Er Chen

Industrial & Engineering Chemistry Research

DOI

2023

Efficient and Scalable Synthesis of Ketoprofen: A Pyrolytic Aromatization Approach

Lili Song, Zhigang Liu, Minjie Liu, Pei Tang, Fen‐Er Chen

Organic Process Research & Development

DOI

2023

Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)-(−)-Praziquantel and Its Analogues

Jinyao Liu, Xiaofan Wu, Zhining Li, Zedu Huang, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2023

New conformationally flexible and recyclable aryl iodine catalysts from an inexpensive chiral source for asymmetric oxidations

Hai-Jie Zhou, Yi-Ping Yao, Tonghui Zhang, Biao Chen, Xu Wang, Hang Zhao, Jie Zeng, Jianai Chen, Xiao Xiao, Fen‐Er Chen

Green Chemistry

DOI

2023

Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development

Yitong Li, Xiaoping Yue, Zhining Li, Zedu Huang, Fen‐Er Chen

Organic Letters

DOI

2023

Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Qingqing Hao, Xiaomei Chen, Xiao-Mei Chen, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2023

Improving solubility of poorly water-soluble drugs by protein-based strategy: A review

Xiaowen Liu, Limin Zhao, Baojian Wu, Fen‐Er Chen

International Journal of Pharmaceutics

DOI

2023

An Efficient and Eco‐Friendly Synthesis of Protoberberine and 13‐Me Protoberberine Alkaloids via Electrochemical Acceptorless Dehydrogenation

Weijian Li, Shiqi Huang, Meifen Jiang, Yu Chen, Zhi‐gang Yang, Pei Tang, Fen‐Er Chen

ChemCatChem

DOI

2023

Anti-aging effect of methylurolithin A and its amide derivatives on nematode Caenorhabditis elegans

Long Tang, Xi Chen, Xiangming Kong, Tian-Wen Liu, Xiaoqing Feng, Fen‐Er Chen, Ziheng Zhuang

Tetrahedron Letters

DOI

2023

Construction of Vicinal All-Carbon Stereogenic Centers via Copper-Catalyzed Asymmetric Decarboxylative Propargylation: Enantio- and Diastereoselective Synthesis of Substituted Spirolactones

Sheng Zuo, Yuan Tao, Zhigang Liu, Ke Zhang, Luyun Zhang, Yingtang Ning, Fen‐Er Chen

Organic Letters

DOI

2023

Additive-controlled asymmetric iodocyclization enables enantioselective access to both α- and β-nucleosides

Qi Wang, Jiayi Mu, Jie Zeng, Lin‐Xi Wan, Yangyang Zhong, Qiuhong Li, Yitong Li, Huijing Wang, Fen‐Er Chen

Nature Communications

DOI

2023

α-Lipoic acid chemistry: the past 70 years

Jiaqi Wang, Xu Ling, Huijing Wang, Fen‐Er Chen

RSC Advances

DOI

2023

Batch and continuous flow asymmetric synthesis of anabolic-androgenic steroids via a single-cell biocatalytic Δ 1 -dehydrogenation and C17β-carbonyl reduction cascade

Yajiao Zhang, Minjie Liu, Zixin Yang, Juan Lin, Zedu Huang, Fen‐Er Chen

Green Chemistry

DOI

2023

Regio- and stereoselective manganese-catalyzed hydrosulfonylation of alkynes: facile access to Z -vinyl sulfones

Jian Han, Lili Zeng, Ronghui Huang, Xiao-Qing Feng, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2023

Highly enantioselective synthesis of both tetrahydroquinoxalines and dihydroquinoxalinones via Rh–thiourea catalyzed asymmetric hydrogenation

Ana Xu, Chaoyi Li, Junrong Huang, Heng Pang, Chengyao Zhao, Lijuan Song, Hengzhi You, Xumu Zhang, Fen‐Er Chen

Chemical Science

DOI

2023

Copper-catalyzed asymmetric allylic alkylation of racemic inert cyclic allylic ethers under batch and flow conditions

Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You, Fen‐Er Chen

Chemical Science

DOI

2023

Chiral spirosiladiphosphines: ligand development and applications in Rh-catalyzed asymmetric hydrosilylation/cyclization of 1,6-enynes with enhanced reactivity

Fei Hou, Minjie Liu, Tong Ru, Zequn Tan, Yingtang Ning, Fen‐Er Chen

Chemical Science

DOI

2023

Photoinduced tandem radical cyclization/heteroarylation of N -allylbromodifluoroacetamides with quinoxalin-2(1 H )-ones or coumarins under metal- and photocatalyst-free conditions

Wei Zhao, Liangming Xuan, Yang Liu, Jiayi Yin, Haifeng Wang, Qiongjiao Yan, Wei Wang, Jin Lin Huang, Fen‐Er Chen

New Journal of Chemistry

DOI

2023

Regio- and stereoselective syntheses of chiral α-quaternary ( Z )-trisubstituted allylic amino acids via synergistic Pd/Cu catalysis

Miaolin Ke, Yuyan Yu, Longwu Sun, Xinzhi Li, Qianqian Cao, Xiao Xiao, Fen‐Er Chen

Chemical Communications

DOI

2023

Hydrogen-free palladium-catalyzed intramolecular anti-Markovnikov hydroaminocarbonylation of 2-(1-methylvinyl)anilines

Tong Ru, Yingtang Ning, Ding Liu, Yuan Tao, Jiaqi Wang, Fen‐Er Chen

Chemical Communications

DOI

2023

Selective reduction of carboxylic esters enabled by a coaxial double-tube continuous-flow reactor with on-the-fly H 2 degassing

Jiale Wu, Xianjing Zheng, Li Qiang Wan, Yuan Tao, Dang Cheng, Fen‐Er Chen

Reaction Chemistry & Engineering

DOI

2023

An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans

Zhining Li, Shiqi Huang, Yuan Tao, Meifen Jiang, Dang Cheng, Li Wan, Fen‐Er Chen

Reaction Chemistry & Engineering

DOI

2023

Palladium-catalyzed decarboxylative allylation of vinyloxazolidin-2-ones with sodium sulfinates: stereoselective assembly of highly functionalized ( Z )-allylic amines

Ledan Zhou, Ding Liu, Hua‐Shan Huang, Ke Zhang, Yingtang Ning, Fen‐Er Chen

Chemical Communications

DOI

2023

Correction: Regioselective O -alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion

Zhewei Yan, Hangli He, Dabiao Yuan, Qiongjiao Yan, Wei Wang, Haipeng Jiang, Haifeng Wang, Fen‐Er Chen

Chemical Communications

DOI

2022

Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S=O to CHOR

Qingqing Hao, Ling Xu, Christophe C. Pannecouque, Erik De Clercq, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

Palladium-catalyzed base- and solvent-controlled chemoselective allylation of amino acids with allylic carbonates

Yang Min Zhou, Hang Chen, Panpan Lei, Chunming Gui, Haifeng Wang, Qiongjiao Yan, Wei Wang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

Concise syntheses of 13-methylprotoberberine and 13-methyltetrahydroprotoberberine alkaloids

Wen‐Chang Chen, Xiaofen Yi, Hongmin Qu, Yu Chen, Pei Tang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity

Ling Xu, Qingqing Hao, Wenjuan Huang, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2022

Quantum hydrogen tunneling promoting halogen-atom and group transfer chemistry

Xiao Xiao, Yiping Yao, Biao Chen, Chuan Xiang Alvin Tan, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2022

Synergistic Pd/Cu catalysis enabled cross-coupling of glycosyl stannanes with sulfonium salts to access C-aryl/alkenyl glycals

Weitao Yan, Mingwen Zheng, Peihsuan Chuang, Hao Sun, Shiping Wang, Chunfa Xu, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs

Ruo-Lan Zhou, Zhiran Ju, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2022

Visible-Light-Promoted Xanthate-Transfer Cyclization Reactions of Unactivated Olefins under Photocatalyst- and Additive-Free Conditions

Tongyao Zhou, Hang Chen, Yang Liu, Haifeng Wang, Qiongjiao Yan, Wei Wang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2022

Stereoselective electrochemical carboxylation of α,β-unsaturated sulfones

Zixin Yang, Liangchuan Lai, Jingze Chen, Hong Yan, Ke‐Yin Ye, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

In vitro and in vivo biological evaluation of newly synthesized multi-target 20(R)-panaxadiol derivatives for treating Alzheimer's disease

Lei Pang, Jin Li, Zheng Liu, Yuan Quan, Hehuan Sui, Yi Jia, Fen‐Er Chen, Jung Joon Lee, Peng Liu, Zhe‐Shan Quan, Qing‐Kun Shen, Hongyan Guo

European Journal of Medicinal Chemistry

DOI

2022

Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability

Xin Jin, Shuai Wang, Limin Zhao, Wenjuan Huang, Yinxiang Zhang, Christophe C. Pannecouque, Erik De Clercq, Ge Meng, Hu‐Ri Piao, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2022

Flow chemistry in the multi-step synthesis of natural products

Li Qiang Wan, Gaopan Kong, Minjie Liu, Meifen Jiang, Dang Cheng, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2022

Copper‐Catalyzed Asymmetric Allylic Alkylation of Racemic Cyclic Allyl Bromides with Organolithium Compounds

Jun Li, Xiao Song, Fusong Wu, Hengzhi You, Fen‐Er Chen

European Journal of Organic Chemistry

DOI

2022

Visible-light-driven intramolecular xanthylation of remote unactivated C(sp3)-H bonds

Hang Chen, Yang Zhou, Panpan Lei, Haifeng Wang, Qiongjiao Yan, Roberta Properzi, Wei Wang, Lin‐Hai Jing, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2022

Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability

Limin Zhao, Shuai Wang, Christophe C. Pannecouque, Erik De Clercq, Hu‐Ri Piao, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2022

Expansion of the S–CN-DABO scaffold to exploit the impact on inhibitory activities against the non-nucleoside HIV-1 reverse transcriptase

Ling Xu, Qingqing Hao, Christophe C. Pannecouque, Erik De Clercq, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2022

Structure-Based Discovery of Novel NH2-Biphenyl-Diarylpyrimidines as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Safety: From NH2-Naphthyl-Diarylpyrimidine to NH2-Biphenyl-Diarylpyrimidine

Xin Jin, Limin Zhao, Shuai Wang, Wenjuan Huang, Yin-Xiang Zhang, Christophe C. Pannecouque, Erik De Clercq, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2022

Benzaldehyde lyase-catalyzed enantioselective C–C bond formation and cleavage: A review

Zhiran Ju, Junde Xu, Zhiyun Li, Jingjie Fang, Menglan Li, Daniel C. Howell, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2022

Recent advances using cyclopropanols and cyclobutanols in ring-opening asymmetric synthesis

Hong Yan, Gregory Stuart Smith, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2022

Recent Progress in Solid‐Phase Total Synthesis of Naturally Occurring Small Peptides

Hong Yan, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2022

Enantioselective Synthesis of Chiral 3‐Alkynyl‐3‐Hydroxyindolin‐ 2‐Ones by Zn/bis(Sulfonamide)‐Diamine Catalyzed Asymmetric Addition of Alkynes to Isatins

Hongmin Qu, Yu Chen, Xiangling Ceng, Pei Tang, Huijing Wang, Fen‐Er Chen

Asian Journal of Organic Chemistry

DOI

2022

Front Cover Picture: Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H‐Pyrrole Derivatives (Adv. Synth. Catal. 11/2022)

Miaolin Ke, Yuyan Yu, Ke Zhang, Sheng Zuo, Zhigang Liu, Xiao Xiao, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2022

Asymmetric Synthesis of Spirooxazolidinone Oxindoles by the Thiourea‐Catalyzed Aldol Reaction of 2‐Isocyanatomalonate Diesters

Xiao‐Pan Chen, Jin‐Xin Liu, Hongyan Li, You‐Cai Xiao, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2022

Small-molecule MDM2 inhibitors in clinical trials for cancer therapy

Shuai Wang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2022

Palladium-Catalyzed Asymmetric [3 + 2] Annulation of Vinylethylene Carbonates with Alkenes Installed on Cyclic N-Sulfonyl Imines: Highly Enantio- and Diastereoselective Construction of Chiral Tetrahydrofuran Scaffolds Bearing Three Vicinal and Quaternary Stereocenters

Miaolin Ke, Bolin Qiao, Yuyan Yu, Xinzhi Li, Xiao Xiao, Shijun Li, Yu Lan, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2022

Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H‐Pyrrole Derivatives

Miaolin Ke, Yuyan Yu, Ke Zhang, Sheng Zuo, Zhigang Liu, Xiao Xiao, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2022

Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK

Li Ding, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2022

Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years

Zhiran Ju, Menglan Li, Junde Xu, Daniel C. Howell, Zhiyun Li, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2022

Structure-Directed Expansion of Biphenyl-Pyridone Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Potency and Safety

Limin Zhao, Christophe C. Pannecouque, Erik De Clercq, Shuai Wang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2022

Structure-Based design of [(2-Hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase Inhibitors: From HEPTs to Sulfinyl-substituted HEPTs

Qingqing Hao, Shuai Wang, Wenjuan Huang, Yinxiang Zhang, Christophe C. Pannecouque, Erik De Clercq, Fen‐Er Chen

Bioorganic Chemistry

DOI

2022

Development of a Fully Continuous‐Flow Approach Towards Asymmetric Total Synthesis of Tetrahydroprotoberberine Natural Alkaloids

Weijian Li, Meifen Jiang, Minjie Liu, Ling Xu, Ying‐Qi Xia, Li Qiang Wan, Fen‐Er Chen

Chemistry - A European Journal

DOI

2022

Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir

Yongxing Guo, Minjie Liu, Meifen Jiang, Yuan Tao, Dang Cheng, Fen‐Er Chen

Engineering

DOI

2022

Stereoselective Total Syntheses of C18-Oxo Eburnamine-Vincamine Alkaloids

Wen Zhang, Zhenzhen Wang, Guodan Lin, Yansong Xue, Mengjuan Wu, Pei Tang, Fen‐Er Chen

Organic Letters

DOI

2022

Ginsengenin derivatives synthesized from 20(R)-panaxotriol: Synthesis, characterization, and antitumor activity targeting HIF-1 pathway

Hong-Yan Guo, Yue Xing, Yu-Qiao Sun, Can Liu, Qian Xu, Fan-Fan Shang, Runhui Zhang, Xuejun Jin, Fen‐Er Chen, Jung Joon Lee, Dongzhou Kang, Qing‐Kun Shen, Zhe‐Shan Quan

Journal of Ginseng Research

DOI

2022

Development of an engineered ketoreductase with improved activity, stereoselectivity and relieved substrate inhibition for enantioselective synthesis of a key (R)-α-lipoic acid precursor

Chen Hu, Baijun Ye, Zedu Huang, Fen‐Er Chen

Molecular Catalysis

DOI

2022

One-Pot Synthesis of Cyclopentenols from Vinylethylene Carbonates via Palladium-Catalyzed Decarboxylative Allylation and Cascade Oxidation-Cyclization

Ke Zhang, Miaolin Ke, Zhigang Liu, Sheng Zuo, Fen‐Er Chen

Bulletin of the Chemical Society of Japan

DOI

2022

Engineered Cyclohexylamine Oxidase with Improved Activity and Stereoselectivity for Asymmetric Synthesis of a Bulky Dextromethorphan Precursor and Its Analogues

Xiaofan Wu, Zhining Li, Juan Lin, Zedu Huang, Fen‐Er Chen

ChemCatChem

DOI

2022

Diastereo- and Enantioselective Synthesis of Borylated 3-Hydroxyoxindoles by Addition of gem-Diborylalkanes to Isatins

Yuan Zhou, Tong Xiong, Liyan Zhou, Hongyan Li, You‐Cai Xiao, Fen‐Er Chen

Organic Letters

DOI

2022

Continuous flow technology-a tool for safer oxidation chemistry

Li Qiang Wan, Meifen Jiang, Dang Cheng, Minjie Liu, Fen‐Er Chen

Reaction Chemistry & Engineering

DOI

2022

Remote C(sp 3 )–H heteroarylation of N -fluorocarboxamides with quinoxalin-2(1 H )-ones under visible-light-induced photocatalyst-free conditions

Liangming Xuan, Ruyang Du, Panpan Lei, Wei Zhao, Lixiang Tan, Chuanzhi Ni, Haifeng Wang, Qiongjiao Yan, Wei Wang, Fen‐Er Chen

Green Chemistry

DOI

2022

Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD 3 -containing scaffolds

Xiao Xiao, Yin-Qiu Huang, Hongyu Tian, Jun Bai, Fei Cheng, Xu Wang, Miaolin Ke, Fen‐Er Chen

Chemical Communications

DOI

2022

Atom- and step-economic 1,3-thiosulfonylation of activated allenes with thiosulfonates to access vinyl sulfones/sulfides

Xiao Xiao, Hongyu Tian, Yin-Qiu Huang, Yin‐Jie Lu, Jingjie Fang, Gao-Jie Zhou, Fen‐Er Chen

Chemical Communications

DOI

2022

Chemical and chemoenzymatic stereoselective synthesis of β-nucleosides and their analogues

Huijing Wang, Yangyang Zhong, You‐Cai Xiao, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2022

Ligand-enabled palladium-catalyzed hydroesterification of vinyl arenes with high linear selectivity to access 3-arylpropanoate esters

Zhixin Deng, Sheng Han, Miaolin Ke, Yingtang Ning, Fen‐Er Chen

Chemical Communications

DOI

2022

TfOH-catalyzed regioselective N 2 -alkylation of indazoles with diazo compounds

Hangli He, Jingyu Yan, Jingru Jin, Zhewei Yan, Qiongjiao Yan, Wei Wang, Haipeng Jiang, Haifeng Wang, Fen‐Er Chen

Chemical Communications

DOI

2022

Water-soluble diphosphine ligands for rhodium-catalyzed branch-selective hydroaminomethylation of vinyl arenes with anilines in water

Luyun Zhang, Yingtang Ning, Baijun Ye, Tong Ru, Fen‐Er Chen

Green Chemistry

DOI

2022

Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem

Xiaoping Yue, Yitong Li, Minjie Liu, Di Sang, Zedu Huang, Fen‐Er Chen

Chemical Communications

DOI

2022

Organocatalytic atroposelective N -alkylation: divergent synthesis of axially chiral sulfonamides and biaryl amino phenols

Xiao Xiao, Yin‐Jie Lu, Hongyu Tian, Hai-Jie Zhou, Jiawei Li, Yi-Ping Yao, Miaolin Ke, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2022

Catalytic asymmetric total synthesis of diazabicyclooctane β-lactamase inhibitors avibactam and relebactam

Zhi‐gang Yang, Yu Chen, Lin‐Xi Wan, Xiangling Cen, Pei Tang, Fen‐Er Chen

Chemical Communications

DOI

2022

A palladium polyaniline complex: a simple and efficient catalyst for batch and flow Suzuki–Miyaura cross-couplings

Dongliang Zhang, Fusong Wu, Zhijian Wan, Yichun Wang, Xuan He, Bing Guo, Hengzhi You, Fen‐Er Chen

Chemical Communications

DOI

2022

Rapid mild macrocyclization of depsipeptides under continuous flow: total syntheses of five cyclodepsipeptides

Jingyuan Liao, Xuelei Jia, Fusong Wu, Junrong Huang, Guifu Shen, Hengzhi You, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2022

A solvent controlled three-component reaction of diazo compounds for the synthesis of hydrazone compounds under Brønsted acid catalysis

Hangli He, Zhewei Yan, Junyong Wang, Qiongjiao Yan, Wei Wang, Haifeng Wang, Fen‐Er Chen

New Journal of Chemistry

DOI

2022

Copper-catalyzed asymmetric alkynylation of pyrazole-4,5-diones using chloramphenicol base-derived hydroxyl oxazoline ligands

Zhaofeng Li, Hong‐Jiao He, Ronghui Wang, Liyan Zhou, You‐Cai Xiao, Fen‐Er Chen

Organic Chemistry Frontiers

DOI

2022

Highly diastereo- and enantioselective synthesis of multisubstituted allylic amino acid derivatives by allylic alkylation of a chiral glycine-based nickel complex and vinylethylene carbonates

Chao Yu, Yuyan Yu, Longwu Sun, Xinzhi Li, Zhigang Liu, Miaolin Ke, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2022

Asymmetric total synthesis of prostaglandin C 2 TBS ether

Xiaofen Yi, Xueyu Long, Yu Chen, Xiangling Cen, Pei Tang, Fen‐Er Chen

Chemical Communications

DOI

2022

Asymmetric total synthesis of (+)-(2 R ,4′ R ,8′ R )-α-tocopherol enabled by enzymatic desymmetrization

Haidi Yang, Jinyao Liu, Pan Hu, Liang Gao, Zedu Huang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2022

TfOH-catalyzed three-component synthesis of Dithiocarbamates from α-Diazoesters under continuous flow conditions

Rui Wang, Hangli He, Qiongjiao Yan, Wei Wang, Haifeng Wang, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2022

Regioselective O -alkylation of 2-pyridones by TfOH-catalyzed carbenoid insertion

Zhewei Yan, Hangli He, Dabiao Yuan, Qiongjiao Yan, Wei Wang, Haipeng Jiang, Haifeng Wang, Fen‐Er Chen

Chemical Communications

DOI

2022

Recoverable PEG-supported amino alcohol ligand for copper-catalyzed Enantio- and syn-selective henry reaction with nitroethanol: Sustainable and straightforward access to chiral syn-2-nitro-1,3-Diols

Ying‐Qi Xia, Yingtang Ning, Minjie Liu, Fen‐Er Chen

Journal of Catalysis

DOI

2022

Synthesis and Evaluation of NF-κB Inhibitory Activity of Mollugin Derivatives

Linhao Zhang, Mingyue Li, Da-Yuan Wang, Xuejun Jin, Fen‐Er Chen, Hu‐Ri Piao

Molecules

DOI

2022

Construction of Non-Biaryl Atropisomeric Amide Scaffolds Bearing a C–N Axis via Enantioselective Catalysis

Xiao Xiao, Biao Chen, Yi-Ping Yao, Hai-Jie Zhou, Xu Wang, Nengzhong Wang, Fen‐Er Chen

Molecules

DOI

2022

Focused mutagenesis in non-catalytic cavity for improving catalytic efficiency of 3-ketosteroid-Δ1-dehydrogenase

Yajiao Zhang, Minjie Liu, Huijing Wang, Juan Lin, Fen‐Er Chen

Molecular Catalysis

DOI

2022

Engineering of Covalent Organic Framework‐Based Advanced Platforms for Enzyme Immobilization: Strategies, Research Progress, and Prospects

Shizhao Wang, Xiaocong Xia, Fen‐Er Chen

Advanced Materials Interfaces

DOI

2022

Continuous-Flow Synthesis of syn-2-Amino-1,3-diol via Catalytic Hydrogenation: A Vital Intermediate of (+)-Thiamphenicol and (+)-Florfenicol

Ying‐Qi Xia, Baijun Ye, Minjie Liu, Meifen Jiang, Fen‐Er Chen

Organic Process Research & Development

DOI

2022

Six‐Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing

Lulu Wang, Minjie Liu, Meifen Jiang, Li Wan, Weijian Li, Dang Cheng, Fen‐Er Chen

Chemistry - A European Journal

DOI

2022

Polymer-Supported Chiral Heterogeneous Copper Catalyst for Asymmetric Conjugate Addition of Ketones and Imines under Batch and Flow

Junwen Wang, Jun Li, Yan Wang, Sisi He, Hengzhi You, Fen‐Er Chen

ACS Catalysis

DOI

2022

Front Cover: Six‐Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing (Chem. Eur. J. 45/2022)

Lulu Wang, Minjie Liu, Meifen Jiang, Li Wan, Weijian Li, Dang Cheng, Fen‐Er Chen

Chemistry - A European Journal

DOI

2022

Detoxification mechanism of vinegar‐processed Kansui revealed by systematic phytochemical analysis using ultrahigh‐performance liquid chromatography diode array detection tandem mass spectrometry, ultrahigh‐performance liquid chromatography high‐resolution mass spectrometry and in silico drug target identification

Liu Lian, Jiangchun Li, Jizhong Lv, Haipeng Jiang, Fen‐Er Chen

Rapid Communications in Mass Spectrometry

DOI

2022

Continuous-flow synthesis of N,N′-bis(2,2,6,6-tetramethyl-4-piperidinyl)-1,6-hexanediamine (DTMPA) in a Micro fixed-bed reactor

Liang Gao, Liangchuan Lai, Baijun Ye, Minjie Liu, Dang Cheng, Meifen Jiang, Fen‐Er Chen

Journal of Flow Chemistry

DOI

2022

Unified total synthesis of eburnamine-vincamine indole alkaloids based on catalytic asymmetric hydrogenation/lactamization cascade

Wen Zhang, Yansong Xue, Srihari Konduri, Guodan Lin, Mengjuan Wu, Pei Tang, Fener Chen

Green Synthesis and Catalysis

DOI

2021

含喹喔啉基咪唑结构的罗丹宁衍生物的合成及其ALK5、抗菌和抗真菌活性研究（英文）

韩立卓，赵丽敏，王慧敏，窦桐，郭芳妍，齐浚答，许文博，朴莲荀，金学军，陈芬儿，朴虎日，郑昌吉，金成华

《有机化学》

2021

流动化学在卤化反应中的应用

刘玎，朱园园，古双喜，陈芬儿

《有机化学》

2021

Skeletal contraction: A novel strategy to access multisubstituted cyclobutane

Chunfa Xu, V. U. Bhaskara Rao, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2021

Catalytic Syn -Selective Nitroaldol Approach to Amphenicol Antibiotics: Evolution of a Unified Asymmetric Synthesis of (−)-Chloramphenicol, (−)-Azidamphenicol, (+)-Thiamphenicol, and (+)-Florfenicol

Ying‐Qi Xia, Meifen Jiang, Minjie Liu, Yan Zhang, Hongmin Qu, Tong Xiong, Hua‐Shan Huang, Dang Cheng, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2021

Harnessing noncovalent interaction of chalcogen bond in organocatalysis: From the catalyst point of view

Weitao Yan, Mingwen Zheng, Chunfa Xu, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2021

Synthesis of rac- α -aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

Peng Gao, Miaolin Ke, Tong Ru, Guanfeng Liang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2021

Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs

Li Ding, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2021

Synthesis and Evaluation of Chiral Rhodanine Derivatives Bearing Quinoxalinyl Imidazole Moiety as ALK5 Inhibitors

Chang Ji Zheng, Cheng Hua Jin, Limin Zhao, Fang Yan Guo, Huimin Wang, Tong Dou, Jun Da Qi, Wen Bo Xu, Lian Xun Piao, Xuejun Jin, Fen‐Er Chen, Hu‐Ri Piao

Medicinal Chemistry

DOI

2021

Total Synthesis of (−)-Canadine, (−)-Rotundine, (−)-Sinactine, and (−)-Xylopinine Using a Last-Step Enantioselective Ir-Catalyzed Hydrogenation

Weijian Li, Meifen Jiang, Wen‐Chang Chen, Yu Chen, Zhi‐gang Yang, Pei Tang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2021

TfOH-Catalyzed [4 + 1] Annulation of p-Quinone Methides with α-Aryl Diazoacetates: Straightforward Access to Highly Functionalized 2,3-Dihydrobenzofurans

Zuolin Lu, Qingchun Zhang, Miaolin Ke, Sha Hu, Xiao Xiao, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2021

Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis

Yingtang Ning, Tomohiko Ohwada, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2021

Synergistic Pd/Cu catalysis for stereoselective allylation of vinylethylene carbonates with glycine iminoesters: Enantioselective access to diverse trisubstituted allylic amino acid derivatives

Miaolin Ke, Zhigang Liu, Ke Zhang, Sheng Zuo, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2021

Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring

Li Ding, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2021

Carbon dioxide cycle via electrocatalysis: Electrochemical carboxylation of CO2 and decarboxylative functionalization of carboxylic acids

Zixin Yang, Yi Yu, Liangchuan Lai, Ledan Zhou, Ke‐Yin Ye, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2021

Room-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand

Ding Liu, Miaolin Ke, Tong Ru, Yingtang Ning, Fen‐Er Chen

Chemical Communications

DOI

2021

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

Fei Cheng, Tao Chen, Yin-Qiu Huang, Jiawei Li, Chen Zhou, Xiao Xiao, Fen‐Er Chen

Organic Letters

DOI

2021

Structure-Based design of Marine-derived Meridianin C derivatives as glycogen synthase kinase 3β inhibitors with improved oral bioavailability: From aminopyrimidyl-indoles to the sulfonyl analogues

Shuwen Han, Wei Min Zhou, Chunlin Zhuang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2021

Palladium-Catalyzed Asymmetric Cross-Coupling Reactions of Cyclobutanols and Unactivated Olefins

Kangning Cao, Zhan‐Ming Zhang, Junliang Zhang, Fen‐Er Chen

Organic Letters

DOI

2021

The total synthesis of ( − ) -strempeliopine via palladium-catalyzed decarboxylative asymmetric allylic alkylation

Yi An, Mengjuan Wu, Weijian Li, Yaling Li, Zhenzhen Wang, Yansong Xue, Pei Tang, Fen‐Er Chen

Chemical Communications

DOI

2021

Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents

Fan-Fan Shang, Mei-Yuan Wang, Jiang-Ping Ai, Qing‐Kun Shen, Hong-Yan Guo, Chunmei Jin, Fen‐Er Chen, Zhe‐Shan Quan, Lili Jin, Changhao Zhang

Medicinal Chemistry Research

DOI

2021

Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B1

Meifen Jiang, Minjie Liu, Hua‐Shan Huang, Fen‐Er Chen

Organic Process Research & Development

DOI

2021

Fully Continuous Flow Synthesis of 3-Chloro-4-oxopentyl Acetate: An Important Intermediate for Vitamin B1

Meifen Jiang, Minjie Liu, Chao Yu, Dang Cheng, Fen‐Er Chen

Organic Process Research & Development

DOI

2021

Phosphorus coordinated Rh single-atom sites on nanodiamond as highly regioselective catalyst for hydroformylation of olefins

Peng Gao, Guanfeng Liang, Tong Ru, Xiaoyan Liu, Haifeng Qi, Aiqin Wang, Fen‐Er Chen

Nature Communications

DOI

2021

Continuous-Flow Asymmetric Synthesis of (3R)-3-Hydroxyl-5-hexenoates with Co-Immobilized Ketoreductase and Lactobacillus kefir Dehydrogenase Integrating Greener Inline Microfluidic Liquid–Liquid Extractors and Membrane Separators

Chen Hu, Zedu Huang, Meifen Jiang, Yuan Tao, Zhining Li, Xiaofan Wu, Dang Cheng, Fen‐Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2021

Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity

Ya-Li Sang, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2021

Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018–2020)

Zhining Li, Haidi Yang, Jinyao Liu, Zedu Huang, Fen‐Er Chen

The Chemical Record

DOI

2021

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Shuwen Han, Chunlin Zhuang, Wei Min Zhou, Fen‐Er Chen

Marine Drugs

DOI

2021

Diastereo‐ and Enantioselective Mannich/Cyclization Cascade Reaction Access to Chiral Benzothiazolopyrimidine Derivatives

Yan Zhang, Jiahui Yang, Ying‐Qi Xia, Lin Dong, Fen‐Er Chen

Chemistry - A European Journal

DOI

2021

A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF 2α , fluprostenol, and travoprost guided by biocatalytic retrosynthesis

Kejie Zhu, Meifen Jiang, Baijun Ye, Guotai Zhang, Weijian Li, Pei Tang, Zedu Huang, Fen‐Er Chen

Chemical Science

DOI

2021

Druggability modification strategies of the diarylpyrimidine‐type non‐nucleoside reverse transcriptase inhibitors

Li Ding, Chunlin Zhuang, Fen‐Er Chen

Medicinal Research Reviews

DOI

2021

Catalytic Asymmetric Addition of Diorganozinc Reagents to Pyrazole‐4,5‐Diones and Indoline‐2,3‐Diones

Ronghui Wang, Ya‐Ling Li, Hong‐Jiao He, You‐Cai Xiao, Fen‐Er Chen

Chemistry - A European Journal

DOI

2021

Nickel-catalyzed cyclization of 1,7-enynes for the selective synthesis of dihydrocyclobuta[ c ]quinolin-3-ones and benzo[ b ]azocin-2-ones

Qiao Li, Yun Cai, Yuanyuan Hu, Hongwei Jin, Fen‐Er Chen, Yunkui Liu, Bingwei Zhou

Chemical Communications

DOI

2021

Stereoselective total synthesis of (±)-vindeburnol and (±)-16- epi -vindeburnol

Xiangtao Chen, Lei Yu, Huijing Wang, Wen Zhang, Pei Tang, Fen‐Er Chen

Chemical Communications

DOI

2021

Palladium( ii )-catalyzed aerobic oxidative O–H/C–H isocyanide insertion: facile access to pyrrolo[2,1- c ][1,4]benzoxazine derivatives

Liangliang Luo, Xiaopan Chen, Zhao-Feng Li, Yuan Zhou, You‐Cai Xiao, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2021

An Effient Synthesis of Pyrrolo[1,2‐a]quinoxaline Derivatives via Isocyanide Insertion into the N−H Bond of 2‐(1H‐pyrrol‐1‐yl)anilines

Liangliang Luo, Tong Xiong, Liyan Zhou, Qin Zeng, You‐Cai Xiao, Fener Chen

Asian Journal of Organic Chemistry

DOI

2021

Enantio‐ and Diastereoselective Synthesis of Chiral Syn‐Aryl β‐Hydroxy α‐Amino Esters via Biocatalytic Dynamic Reductive Kinetic Resolution

Qing‐Chun Zhang, Zuolin Lu, Hu Chen, Kejie Zhu, Meifen Jiang, Zedu Huang, Fener Chen

Asian Journal of Organic Chemistry

DOI

2021

Stereoselective Synthesis of ( Z )‐Dihomoallylic Phosphonates with Quaternary Carbon Center by Palladium‐Catalyzed Bisallylation of Vinylethyene Carbonates with β ‐Ketophosphonates

Zhigang Liu, Miaolin Ke, Ke Zhang, Sheng Zuo, Meifen Jiang, Fener Chen

Asian Journal of Organic Chemistry

DOI

2021

Linear Selective Hydroformylation of 2‐Arylpropenes Using Water‐Soluble Rh‐PNP Complex: Straightforward Access to 3‐Aryl‐Butyraldehydes

Tong Ru, Guanfeng Liang, Luyun Zhang, Yingtang Ning, Fener Chen

ChemCatChem

DOI

2021

Time‐Economical Synthesis of Diarylacetates Enabled by TfOH‐Catalyzed Arylation of α‐Aryl‐α‐Diazoesters with Arenes

Sha Hu, Jiale Wu, Zuolin Lu, Jiaqi Wang, Yuan Tao, Meifen Jiang, Fener Chen

ChemCatChem

DOI

2021

Palladium‐Catalyzed Allylation of Vinylethylene Carbonates with β‐Ketophosphonates: Stereoselective Synthesis of (Z)‐Homoallylic Phosphonates

Zhigang Liu, Miaolin Ke, Ke Zhang, Zexu Wang, Baijun Ye, Fener Chen

ChemCatChem

DOI

2020

Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Daxiong Li, Chunsheng Zhang, Wei Ding, Siming Huang, Le Yu, Nan Lu, Wenkai Pan, Yiming Li, Erik De Clercq, Christophe C. Pannecouque, Hongbing Zhang, Yueping Wang, Yan‐Ping He, Fen‐Er Chen

Chinese Chemical Letters

DOI

2020

Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives

Yizhen Yin, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2020

TfOH-Catalyzed N–H Insertion of α-Substituted-α-Diazoesters with Anilines Provides Access to Unnatural α-Amino Esters

Sha Hu, Jiale Wu, Zuolin Lu, Jiaqi Wang, Yuan Tao, Meifen Jiang, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2020

Unified Strategy to Amphenicol Antibiotics: Asymmetric Synthesis of (−)-Chloramphenicol, (−)-Azidamphenicol, and (+)-Thiamphenicol and Its (+)-3-Floride

Jinxin Liu, Yaling Li, Miaolin Ke, Minjie Liu, Pingping Zhan, You‐Cai Xiao, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2020

Synthesis of Fused Polycyclic 4‐Anilinoquinazolines and N‐Quinazoline‐Indoles via Selective C−H Bond Activation

Xin‐Yang Liu, Hao Liu, Xian‐Zhang Liao, Lin Dong, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2020

Recent Advances in Asymmetric Organomulticatalysis

Xiao Xiao, Bingxuan Shao, Yin‐Jie Lu, Qian‐Qian Cao, Chun‐Nian Xia, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2020

TfOH-Catalyzed Cascade C–H Activation/Lactonization of Phenols with α-Aryl-α-diazoesters: Rapid Access to α-Aryl Benzofuranones

Sha Hu, Zuolin Lu, Minjie Liu, Hanlin Xu, Jiale Wu, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2020

Transition-metal catalyzed asymmetric reactions under continuous flow from 2015 to early 2020

Jingyuan Liao, Shilong Zhang, Zesheng Wang, Xiao Song, Dongliang Zhang, Ravi Kumar, Jian Guo Jin, Peng Ren, Hengzhi You, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2020

Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors

Xiaomei Chen, Li Ding, Yuan Tao, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2020

Asymmetric Alkynylation of Cyclic N‐Sulfonyl Imines using Synergistic Chiral Phosphoric Acid/Copper Catalysis

Ya‐Ling Li, Jin‐Xin Liu, Xiao‐Pan Chen, Yuan Zhou, You‐Cai Xiao, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2020

Rh( iii )-Catalyzed three-component cascade annulation to produce the N -oxopropyl chain of isoquinolone derivatives

Yuan He, Xian‐Zhang Liao, Lin Dong, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2020

Design strategies for long-acting anti-HIV pharmaceuticals

Ya-Li Sang, Li Ding, Chunlin Zhuang, Fen‐Er Chen

Current Opinion in Pharmacology

DOI

2020

Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain

Chen Hu, Minjie Liu, Xiaoping Yue, Zedu Huang, Fen‐Er Chen

Organic Process Research & Development

DOI

2020

Enantioselective Total Syntheses of (−)‐20‐epi‐Vincamine and (−)‐20‐epi‐Eburnamonine by Ir‐Catalyzed Asymmetric Imine Hydrogenation/Lactamization Cascade

Wen Zhang, Xiangtao Chen, Yi An, Jiaqi Wang, Chunlin Zhuang, Pei Tang, Fen‐Er Chen

Chemistry - A European Journal

DOI

2020

Natural Occurrence, Biological Functions, and Analysis of D-Amino Acids

Shuang‐Xi Gu, Haifeng Wang, Yuan‐Yuan Zhu, Fen‐Er Chen

Pharmaceutical Fronts

DOI

2020

Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Vinylethylene Carbonates with Ketimine Esters to Generate (Z)-Tri- and Tetra-substituted Allylic Amino Acid Derivatives

Miaolin Ke, Zhigang Liu, Guanxin Huang, Jiaqi Wang, Yuan Tao, Fen‐Er Chen

Organic Letters

DOI

2020

Privileged scaffold inspired design of novel oxime-biphenyl-DAPYs in treatment of HIV-1

Yang Yang, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2020

Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs

Tingting Li, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Molecules

DOI

2020

Stereoselective Synthesis of (−)-Verazine and Congeners via a Cascade Ring-Switching Process of Furostan-26-acid

Yun Wang, Yong Shi, Weisheng Tian, Pei Tang, Chunlin Zhuang, Fen‐Er Chen

Organic Letters

DOI

2020

Recent Advances of Pharmaceutical Process Chemistry and Its Innovation in China: Part 1

Pei Tang, Biao Nie, Jiuzhong Huang, Ying‐Jun Zhang, Ji Zhang, Fen‐Er Chen

Pharmaceutical Fronts

DOI

2020

Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy

Yuan Lei, Sheng Han, Yang Yang, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Molecules

DOI

2020

Experimental and Numerical Studies of the Phase-Transfer-Catalyzed Wittig Reaction in Liquid–Liquid Slug-Flow Microchannels

Dang Cheng, Fen‐Er Chen

Industrial & Engineering Chemistry Research

DOI

2020

Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase

Ya-Li Sang, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2020

Asymmetric catalysis in direct nitromethane-free Henry reactions

Lin Dong, Fen‐Er Chen

RSC Advances

DOI

2020

Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides

Liangliang Luo, Hongyan Li, Jinxin Liu, Yuan Zhou, Lin Dong, You‐Cai Xiao, Fen‐Er Chen

RSC Advances

DOI

2020

Access to chiral α-substituted-β-hydroxy arylphosphonates enabled by biocatalytic dynamic reductive kinetic resolution

Zexu Wang, Yiping Zeng, Xiaofan Wu, Zihan Li, Yuan Tao, Xiaomin Yu, Zedu Huang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2020

Asymmetric synthesis of (−)-solanidine and (−)-tomatidenol

Yun Wang, Guanxin Huang, Yong Shi, Weisheng Tian, Chunlin Zhuang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2020

Correction: Asymmetric synthesis of (−)-solanidine and (−)-tomatidenol

Yun Wang, Guanxin Huang, Yong Shi, Weisheng Tian, Chunlin Zhuang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2020

Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis

Pei Tang, Huijing Wang, Wen Zhang, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2020

Asymmetric catalysis in synthetic strategies for chiral benzothiazepines

Haifeng Wang, Shuang‐Xi Gu, Qiongjiao Yan, Li Ding, Fen‐Er Chen

Green Synthesis and Catalysis

DOI

2020

Specific Z-Selectivity in the Oxidative Isomerization of Allyl Ethers to Generate Geometrically Defined Z-Enol Ethers Using a Cobalt(II)(salen) Complex Catalyst

Guanxin Huang, Miaolin Ke, Yuan Tao, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2020

Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight

Xiaofan Wu, Zedu Huang, Zexu Wang, Zhining Li, Jiaqi Wang, Juan Lin, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2019

Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Kaijun Jin, Minjie Liu, Chunlin Zhuang, Erik De Clercq, Christophe C. Pannecouque, Ge Meng, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2019

Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Chunlin Zhuang, Christophe C. Pannecouque, Erik De Clercq, Fen‐Er Chen

Acta Pharmaceutica Sinica B

DOI

2019

Fragment-based discovery of sulfur-containing diarylbenzopyrimidines as novel nonnucleoside reverse transcriptase inhibitors

Sheng Han, Yuan Lei, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Chinese Chemical Letters

DOI

2019

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains

Kaijun Jin, Ya-Li Sang, Sheng Han, Erik De Clercq, Christophe C. Pannecouque, Ge Meng, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

连续流微反应技术在药物合成中的应用研究进展

程荡，陈芬儿

《化工进展》

DOI

2019

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV‑1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles

Sheng Han, Ya-Li Sang, Yan Wu, Yuan Tao, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

ACS Infectious Diseases

DOI

2019

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains

Ya-Li Sang, Sheng Han, Shuwen Han, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Bioorganic Chemistry

DOI

2019

Cover Feature: Chloramphenicol Base: A New Privileged Chiral Scaffold in Asymmetric Catalysis (ChemCatChem 8/2019)

You‐Cai Xiao, Fen‐Er Chen

ChemCatChem

DOI

2019

Chloramphenicol Base: A New Privileged Chiral Scaffold in Asymmetric Catalysis

You‐Cai Xiao, Fen‐Er Chen

ChemCatChem

DOI

2019

Ketoreductase catalyzed stereoselective bioreduction of α-nitro ketones

Zexu Wang, Xiaofan Wu, Zhining Li, Zedu Huang, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2019

The Chapman rearrangement in a continuous-flow microreactor

Jingjie Fang, Miaolin Ke, Guanxin Huang, Yuan Tao, Dang Cheng, Fen‐Er Chen

RSC Advances

DOI

2019

Organocatalytic Asymmetric Domino Oxa-Michael–Mannich-[1,3]-Amino Rearrangement Reaction of N-Tosylsalicylimines to α,β-Unsaturated Aldehydes by Diarylprolinol Silyl Ethers

Sha Hu, Jiaqi Wang, Guanxin Huang, Kejie Zhu, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2019

Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles

Ya-Li Sang, Sheng Han, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2019

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors

Sheng Han, Ya-Li Sang, Yan Wu, Yuan Tao, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Indazolyl-substituted piperidin-4-yl-aminopyrimidines as HIV-1 NNRTIs: Design, synthesis and biological activities

Ting Xiao, Jia-Fan Tang, Ge Meng, Christophe C. Pannecouque, Yuan‐Yuan Zhu, Genyan Liu, Zhiqiang Xu, Fengshou Wu, Shuang‐Xi Gu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Small-Molecule Inhibitors of Necroptosis: Current Status and Perspectives

Chunlin Zhuang, Fen‐Er Chen

Journal of Medicinal Chemistry

DOI

2019

Cover Feature: A Formal Synthesis of Camptothecin via a Photocatalytic Decarboxylative Radical Addition (Eur. J. Org. Chem. 35/2019)

Qian Liu, Guanxin Huang, Minjie Liu, Fen‐Er Chen

European Journal of Organic Chemistry

DOI

2019

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors

Ya-Li Sang, Sheng Han, Christophe C. Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

A Formal Synthesis of Camptothecin via a Photocatalytic Decarboxylative Radical Addition

Qian Liu, Guanxin Huang, Minjie Liu, Fen‐Er Chen

European Journal of Organic Chemistry

DOI

2019

A Concise Total Synthesis of (±)-Camptothecin

Qian Liu, Guanxin Huang, Min-jie Liu, Fen‐Er Chen

Synthesis

DOI

2019

Recent progress in HIV-1 inhibitors targeting the entrance channel of HIV-1 non-nucleoside reverse transcriptase inhibitor binding pocket

Shuang‐Xi Gu, Ting Xiao, Yuan‐Yuan Zhu, Genyan Liu, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2019

Access to a Key Building Block for the Prostaglandin Family via Stereocontrolled Organocatalytic Baeyer–Villiger Oxidation

Kejie Zhu, Sha Hu, Minjie Liu, Haihui Peng, Fen‐Er Chen

Angewandte Chemie

DOI

2019

Asymmetric total synthesis of (20S)-Camptothecin using a chiral auxiliary strategy

Qian Liu, Minjie Liu, Guangxin Huang, Fen‐Er Chen

Tetrahedron

DOI

2019

Substituent Position‐Controlled Stereoselectivity in Enzymatic Reduction of Diaryl‐ and Aryl(heteroaryl)methanones

Zhining Li, Zexu Wang, Yuhan Wang, Xiaofan Wu, Hong Lu, Zedu Huang, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2019

Direct Synthesis of Substituted (Z)‐Allylic Sulfones by Palladium‐Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates

Miaolin Ke, Guanxin Huang, Li Ding, Jingjie Fang, Fener Chen

ChemCatChem

DOI

2018

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng, Fen‐Er Chen

iScience

DOI

2018

Development of Novel Chloramphenicol Scaffold‐Based Chiral Hydroxyl Oxazoline Ligands and Their Application to the Asymmetric Alkynylation of Isatins

Lei Chen, Guanxin Huang, Minjie Liu, Zedu Huang, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2018

Front Cover: Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of (R)‐Profen Esters (Asian J. Org. Chem. 4/2018)

Zhining Li, Zexu Wang, Ge Meng, Hong Lu, Zedu Huang, Fen‐Er Chen

Asian Journal of Organic Chemistry

DOI

2018

Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of (R)‐Profen Esters

Zhining Li, Zexu Wang, Ge Meng, Hong Lu, Zedu Huang, Fen‐Er Chen

Asian Journal of Organic Chemistry

DOI

2018

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1

Kaijun Jin, Hong Yin, Erik De Clercq, Christophe C. Pannecouque, Ge Meng, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2018

Novel amide-functionalized chloramphenicol base bifunctional organocatalysts for enantioselective alcoholysis ofmeso-cyclic anhydrides

Lingjun Xu, Shuwen Han, Linjie Yan, Haifeng Wang, Haihui Peng, Fener Chen

Beilstein Journal of Organic Chemistry

DOI

2017

Discovery of Biphenyl-Substituted Diarylpyrimidines as New Non-Nucleoside HIV-1 Reverse Transcripttase Inhibitors

Kaijun Jin, Ge Meng, Fen‐Er Chen, Erik De Clercq, Christophe C. Pannecouque

DOI

2017

Designing Novel Hydrazinecarbothioamides as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Hong Yin, Zheng-Yong Wan, Ge Meng, Fen‐Er Chen, Erik De Clercq, Christophe C. Pannecouque

DOI

2017

Chloramphenicol base chemistry. Part 11: chloramphenicol base-derived thiourea-catalyzed enantioselective Michael addition of malononitrile to α,β-unsaturated ketones

Linjie Yan, Haifeng Wang, Fangjun Xiong, Yuan Tao, Yan Wu, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2017

An improved synthesis of (20S)-camptothecin and its analogue via an asymmetric α-hydroxylation with a chiral organocatalyst

Xinlong Wang, Lingjun Xu, Fangjun Xiong, Yan Wu, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2017

Total Synthesis of Camptothecins: An Update

Fen‐Er Chen, Lei Chen

Synlett

DOI

2017

Structural Modifications of Diarylpyrimidine-quinolone Hybrids as Potent HIV-1 NNRTIs with an Improved Drug Resistance Profile

Tian-Qi Mao, Qiuqin He, Wenxue Chen, Gangfeng Tang, Fen‐Er Chen, Erik De Clercq, Dirk Daelemans, Christophe C. Pannecouque

Current Pharmaceutical Design

DOI

2017

Base-controlled highly selective synthesis of alkyl 1,2-bis(boronates) or 1,1,2-tris(boronates) from terminal alkynes

Guoliang Gao, Jianxiang Yan, Kai Huai Yang, Fen‐Er Chen, Qiuling Song

Green Chemistry

DOI

2017

Recent advances in asymmetric total synthesis of prostaglandins

Haihui Peng, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2017

Nucleoside-linked shunt products in the reaction catalyzed by the class C radical S-adenosylmethionine methyltransferase NosN

Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fen‐Er Chen, Zixin Deng, Yi Yu, Qi Zhang

Chemical Communications

DOI

2017

Enantioselective β -hydroxy thioesters formation via decarboxylative aldol reactions of malonic acid half thioesters with aldehydes promoted by chloramphenicol derived sulfonamides 1

Yafeng Wang, Guanxin Huang, Sha Hu, Kaijun Jin, Yan Wu, Fen‐Er Chen

Tetrahedron

DOI

2017

Chloramphenicol base chemistry. Part 10 1 : Asymmetric synthesis of α -hydroxy chiral alcohols via intramolecular Michael additions of γ -hydroxy- α , β -unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts

Haifeng Wang, Linjie Yan, Yan Wu, Fen‐Er Chen

Tetrahedron

DOI

2017

Innentitelbild: The Catalytic Mechanism of the Class C Radical S‐Adenosylmethionine Methyltransferase NosN (Angew. Chem. 14/2017)

Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Tao Tu, Zixin Deng, Yi Qiang Yu, Fen‐Er Chen, Qi Zhang

Angewandte Chemie

DOI

2017

Inside Cover: The Catalytic Mechanism of the Class C Radical S‐Adenosylmethionine Methyltransferase NosN (Angew. Chem. Int. Ed. 14/2017)

Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Tao Tu, Zixin Deng, Yi Qiang Yu, Fen‐Er Chen, Qi Zhang

Angewandte Chemie International Edition

DOI

2017

The Catalytic Mechanism of the Class C Radical S‐Adenosylmethionine Methyltransferase NosN

Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Tao Tu, Zixin Deng, Yi Yu, Fen‐Er Chen, Qi Zhang

Angewandte Chemie

DOI

2017

Squaramide‐Linked Chloramphenicol Base Hybrid Catalysts for the Asymmetric Michael Addition of 2,3‐Dihydrobenzofuran‐2‐carboxylates to Nitroolefins

Linjie Yan, Guanxin Huang, Haifeng Wang, Fangjun Xiong, Haihui Peng, Fener Chen

European Journal of Organic Chemistry

DOI

2017

Asymmetric Synthesis of Atorvastatin Calcium through Intramolecular Oxidative Oxygen‐Nucleophilic Bromocyclization

Yan Wu, Minjie Liu, Hai‐Qing Huang, Guanxin Huang, Fangjun Xiong, Fener Chen

European Journal of Organic Chemistry

DOI

2016

Multigram scale, chiron-based synthesis of sacubitril

Yun Wang, Fen‐Er Chen, Yong Shi, Weisheng Tian

Tetrahedron Letters

DOI

2016

Development of Bifunctional Thiourea Organocatalysts Derived from a Chloramphenicol Base Scaffold and their Use in the Enantioselective Alcoholysis of meso Cyclic Anhydrides

Linjie Yan, Haifeng Wang, Wenxue Chen, Yuan Tao, Kaijun Jin, Fen‐Er Chen

ChemCatChem

DOI

2016

A novel synthetic route to 7-MAC from 7-ACA

Fei Xiong, Gen Li, Bo Song, Fen‐Er Chen, Zhao‐Sen Zeng

Journal of the Iranian Chemical Society

DOI

2016

New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α,β-unsaturated aldehydes with diketene: a short synthesis of atorvastatin calcium

Haifeng Wang, Linjie Yan, Fangjun Xiong, Yan Wu, Fen‐Er Chen

RSC Advances

DOI

2016

Preparation of (+)-Biotin: Process Development and Scale-up

Fei Xiong, Jin Li, Gen Li, Bo Song, Yuxiao Zhou, Fen‐Er Chen, Dan Li

Heterocycles

DOI

2016

Catalytic asymmetric transfer hydrogenation/dynamic kinetic resolution: an efficient synthesis of florfenicol

Xinlong Wang, Lingjun Xu, Lingjie Yan, Haifeng Wang, Sheng Han, Yan Wu, Fen‐Er Chen

Tetrahedron

DOI

2016

ChemInform Abstract: A New Cost‐Effective Ru‐Chloramphenicol Base Derivative Catalyst for the Asymmetric Transfer Hydrogenation/Dynamic Kinetic Resolution of N‐Boc α‐Amino‐β‐ketoesters and Its Application to the Synthesis of the Chiral Core of Vancomycin.

Xinlong Wang, Lingjun Xu, Fangjun Xiong, Yan Wu, Fener Chen

ChemInform

DOI

2016

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

Xinlong Wang, Lingjun Xu, Fangjun Xiong, Yan Wu, Fener Chen

RSC Advances

DOI

2015

S-DAPYs类似物的分子设计、合成及抑制HIV-1的活性研究

万正勇，陈芬儿，Erik De Clercq，Dirk Daelemans，Christophe Pannecouque

《中国科学:化学》

2015

Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction.

Fang-Jun Xiong, Haifeng Wang, Lingjie Yan, Lingjun Xu, Yuan Tao, Yan Wu, Fener Chen

Organic and biomolecular chemistry

DOI

2015

Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization

Fangjun Xiong, Haifeng Wang, Lingjie Yan, Sheng Han, Yuan Tao, Yan Wu, Fen‐Er Chen

Organic & Biomolecular Chemistry

DOI

2015

ChemInform Abstract: Stereoselective Synthesis of 3‐Hydroxy‐3‐methylglutaryl—Coenzyme A Reductase Inhibitors

Yan Wu, Fangjun Xiong, Fen‐Er Chen

ChemInform

DOI

2015

ChemInform Abstract: Organocatalytic Asymmetric Vinylogous Michael Addition of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona‐Based Squaramide.

Zheng Chen, Haifeng Wang, Wei‐Qi Chen, Wenxue Chen, Fen‐Er Chen

ChemInform

DOI

2015

Design, synthesis and biological evaluation of S-DAPY derivatives as novel HIV-1 inhibitors

Erik De Clercq, Dirk Daelemans, Zheng-Yong Wan, Fen‐Er Chen

Scientia Sinica Chimica

DOI

2015

Hybrid chemistry. Part 4: Discovery of etravirine–VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Zheng-Yong Wan, Yuan Tao, Ya-Feng Wang, Tian-Qi Mao, Hong Yin, Fen‐Er Chen, Hu‐Ri Piao, Erik De Clercq, Dirk Daelemans, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2015

Anti-HIV diarylpyrimidine–quinolone hybrids and their mode of action

Tian-Qi Mao, Qiuqin He, Zheng-Yong Wan, Wenxue Chen, Fen‐Er Chen, Gangfeng Tang, Erik De Clercq, Dirk Daelemans, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2015

Asymmetric Amination of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates Catalyzed by a Cinchona‐Derived Alkaloid

Zheng Chen, Wenxue Chen, Fen‐Er Chen

Asian Journal of Organic Chemistry

DOI

2015

Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue

Zheng-Yong Wan, Jin Yao, Tian-Qi Mao, Xin-Long Wang, Haifeng Wang, Wenxue Chen, Hong Yin, Fen‐Er Chen, Erik De Clercq, Dirk Daelemans, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2015

Stereoselective synthesis of 3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors

Yan Wu, Fangjun Xiong, Fen‐Er Chen

Tetrahedron

DOI

2015

Substrate stereocontrol in bromine-induced intermolecular cyclization: asymmetric synthesis of pitavastatin calcium

Weiqi Chen, Fangjun Xiong, Qian Liu, Lingjun Xu, Yan Wu, Fen‐Er Chen

Tetrahedron

DOI

2015

Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Zheng-Yong Wan, Jin Yao, Yuan Tao, Tian-Qi Mao, Xin-Long Wang, Yi-Pei Lu, Haifeng Wang, Hong Yin, Yan Wu, Fen‐Er Chen, Erik De Clercq, Dirk Daelemans, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2015

Organocatalytic Asymmetric Vinylogous Michael Addition of 3‐(2‐Oxoindolin‐3‐ylidene)butanoates to Nitroalkenes Catalyzed by a Bifunctional Cinchona‐Based Squaramide

Zheng Chen, Haifeng Wang, Wei‐Qi Chen, Wenxue Chen, Fen‐Er Chen

Asian Journal of Organic Chemistry

DOI

2015

Asymmetric Synthesis of Vitamin D3 Analogues: Organocatalytic Desymmetrization Approach toward the A-Ring Precursor of Calcifediol

Haifeng Wang, Linjie Yan, Yan Wu, Yi-Pei Lu, Fener Chen

Organic Letters

DOI

2014

(3aS,6aR)-1,3-双(4-甲氧苄基)-四氢-1H-噻吩并[3,4-d]咪唑-2,4-二酮的不对称合成

李丹，熊方均，熊非，陈芬儿

《中国医药工业杂志》

2014

ChemInform Abstract: An Efficient Synthesis of Katsube Nitrile: A Key Building Block for Eburnamine‐Vincamine Alkaloids.

Xiaofei Chen, Fen‐Er Chen

ChemInform

DOI

2014

ChemInform Abstract: An Efficient Method for the Resolution of rac‐VANOL by Molecular Complexation with (1S,2S)‐(+)‐Diaminocyclohexane.

Zheng Chen, Fen‐Er Chen

ChemInform

DOI

2014

Synthesis and biological evaluation of DAPY–DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Hai-Qiu Wu, Jin Yao, Qiuqin He, Wenxue Chen, Fen‐Er Chen, Christophe C. Pannecouque, Erik De Clercq, Dirk Daelemans

Bioorganic & Medicinal Chemistry

DOI

2014

ChemInform Abstract: Asymmetric Synthesis of the HMG‐CoA Reductase Inhibitor Atorvastatin Calcium: An Organocatalytic Anhydride Desymmetrization and Cyanide‐Free Side Chain Elongation Approach.

Xiaofei Chen, Fangjun Xiong, Wenxue Chen, Qiuqin He, Fen‐Er Chen

ChemInform

DOI

2014

An improved process for chiron synthesis of the atorvastatin side chain

Fangjun Xiong, Jie Li, Xiao-Fei Chen, Wenxue Chen, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2014

Structural modification of diarylpyrimidine derivatives as HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Yuan‐Yuan Zhu, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Medicinal Chemistry Research

DOI

2014

Design and synthesis of a new series of cyclopropylamino-linking diarylpyrimidines as HIV non-nucleoside reverse transcriptase inhibitors

Yang Liu, Ge Meng, Aqun Zheng, Fen‐Er Chen, Wenxue Chen, Erik De Clercq, Christophe C. Pannecouque, Jan M. Balzarini

European Journal of Pharmaceutical Sciences

DOI

2014

An efficient method for the resolution of rac-VANOL by molecular complexation with (1S,2S)-(+)-diaminocyclohexane

Zheng Chen, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2014

ChemInform Abstract: Asymmetric Catalytic Anhydride Openings via Carbon‐Based Nucleophiles

Zheng Chen, Fen‐Er Chen

ChemInform

DOI

2014

Synthesis and biological evaluation of CHX-DAPYs as HIV-1 non-nucleoside reverse transcriptase inhibitors

Zihong Yan, Hai-Qiu Wu, Wenxue Chen, Yan Wu, Hu‐Ri Piao, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2014

Structural modifications of CH(OH)-DAPYs as new HIV-1 non-nucleoside reverse transcriptase inhibitors

Zihong Yan, Xiayun Huang, Hai-Qiu Wu, Wenxue Chen, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2014

Docking-based CoMFA and CoMSIA studies on naphthyl-substituted diarylpyrimidines as NNRTIs

Hai-Qiu Wu, Jin Yao, Qiuqin He, Fen‐Er Chen

SAR and QSAR in environmental research

DOI

2014

Synthetic studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy

Xiaofei Chen, Fangjun Xiong, Zheng Chen, Jie Li, Fen‐Er Chen

Tetrahedron

DOI

2014

Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors

Ge Meng, Yang Liu, Aqun Zheng, Fen‐Er Chen, Wenxue Chen, Erik De Clercq, Christophe C. Pannecouque, Jan M. Balzarini

European Journal of Medicinal Chemistry

DOI

2014

An Efficient Synthesis of Katsube Nitrile: A Key Building Block for Eburnamine-Vincamine Alkaloids

Fen‐Er Chen, Xiaofei Chen

Synthesis

DOI

2014

Asymmetric Synthesis of the HMG-CoA Reductase Inhibitor Atorvastatin Calcium: An Organocatalytic Anhydride Desymmetrization and Cyanide-Free Side Chain Elongation Approach

Xiaofei Chen, Fangjun Xiong, Wenxue Chen, Qiuqin He, Fen‐Er Chen

The Journal of Organic Chemistry

DOI

2014

Synthesis and biological evaluation of new conformationally restricted S-DABO hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Hai-Qiu Wu, Christophe C. Pannecouque, Zihong Yan, Wenxue Chen, Qiuqin He, Fen‐Er Chen, Jan M. Balzarini, Dirk Daelemans, Erik De Clercq

MedChemComm

DOI

2013

Asymmetric catalytic anhydride openings via carbon-based nucleophiles

Zheng Chen, Fen‐Er Chen

Chinese Chemical Letters

DOI

2013

Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin

Hongjun Yang, Fangjun Xiong, Xiaofei Chen, Fen‐Er Chen

European Journal of Organic Chemistry

DOI

2013

A family of novel bifunctional organocatalysts: Highly enantioselective alcoholysis of meso cyclic anhydrides and its application for synthesis of the key intermediate of P2X7 receptor antagonists

Hongjun Yang, Fangjun Xiong, Jie Li, Fen‐Er Chen

Chinese Chemical Letters

DOI

2013

Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors

Shiqiong Yang, Christophe C. Pannecouque, Dirk Daelemans, Xiaodong Ma, Yang Liu, Fen‐Er Chen, Erik De Clercq

European Journal of Medicinal Chemistry

DOI

2013

ChemInform Abstract: Highly Enantioselective Thiolysis of Prochiral Cyclic Anhydrides Catalyzed by Amino Alcohol Bifunctional Organocatalysts and Its Application to the Synthesis of Pregabalin (XIII).

Hongjun Yang, Fangjun Xiong, Xiaofei Chen, Fen‐Er Chen

ChemInform

DOI

2013

Development of an Efficient Process for the Decomposition of the Borate Complexes Formed during the Large-Scale Synthesis of (S)-1,2,4-Butanetriol

Qian Liu, Fangjun Xiong, Qiuqin He, Fen‐Er Chen

Organic Process Research & Development

DOI

2013

ChemInform Abstract: A Family of Novel Bifunctional Organocatalysts: Highly Enantioselective Alcoholysis of meso Cyclic Anhydrides and Its Application for Synthesis of the Key Intermediate of P2X7 Receptor Antagonists.

Hongjun Yang, Fangjun Xiong, Jie Li, Fen‐Er Chen

ChemInform

DOI

2013

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

Hai-Qiu Wu, Zihong Yan, Wenxue Chen, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Dirk Daelemans, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2013

Highly EnantioselectiveMethanolysis of Meso‐Cyclic Anhydride Mediated by Bifunctional Thiourea Cinchona Alkaloid Derivatives: Access to Asymmetric Total Synthesis of (+)‐Biotin

Fei Xiong, Fangjun Xiong, Wenxue Chen, Hui‐Qing Jia, Fen‐Er Chen

Journal of Heterocyclic Chemistry

DOI

2013

Synthetic studies on statins. Part 1: a short and cyanide-free synthesis of atorvastatin calcium via an enantioselective aldol strategy

Lemeng Hu, Fangjun Xiong, Xiaofei Chen, Wenxue Chen, Qiuqin He, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2012

2-(2-芳基)乙基苯甲酸的合成

谢艳，郑土才，周文军，陈芬儿

《中国医药工业杂志》

2012

(+)-生物素全合成研究新进展

钟铮，武雪芬，陈芬儿

《有机化学》

2012

Asymmetric Aldol Reactions of Heterocyclic Dienolsilanes and α,β-Unsaturated Carbonyl Derived Dienolsilanes

Fen‐Er Chen, Zhenyuan Miao

Synthesis

DOI

2012

Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Zhiming Li, Xiao-Dong Ma, Shiqiong Yang, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2012

Synthesis, structure–activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors

Xiao-Dong Ma, Qiuqin He, Xuan Zhang, Shiqiong Yang, Liu‐Meng Yang, Shuang‐Xi Gu, Yong‐Tang Zheng, Fen‐Er Chen, Hui‐Fang Dai

European Journal of Medicinal Chemistry

DOI

2012

ChemInform Abstract: Asymmetric Aldol Reactions of Heterocyclic Dienolsilanes and α,β‐Unsaturated Carbonyl Derived Dienolsilanes

Zhenyuan Miao, Fen‐Er Chen

ChemInform

DOI

2012

ChemInform Abstract: Direct Bifunctional Squaramide‐Catalyzed Asymmetric N‐Nitroso Aldol Reaction of Tertiary β‐Carbonyl Esters.

Hongjun Yang, Le Dai, Shi‐Qiong Yang, Fen‐Er Chen

ChemInform

DOI

2012

ChemInform Abstract: Enantioselective Protonation in the Sulfa‐Michael Addition Using Chiral Squaramides as Hydrogen‐Bonding Organocatalysts.

Le Dai, Hongjun Yang, Jingze Niu, Fen‐Er Chen

ChemInform

DOI

2012

Synthesis and biological evaluation of 5-fluoroquinolone-3-carboxylic acids as potential HIV-1 integrase inhibitors

Qiuqin He, Xuan Zhang, Liu‐Meng Yang, Yong‐Tang Zheng, Fen‐Er Chen

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI

2012

ChemInform Abstract: Chiral Squaramide‐Catalyzed Enantioselective Conjugate Michael Addition of Various Thiols to α,β‐Unsaturated N‐Acylated Oxazolidin‐2‐ones.

Le Dai, Hongjun Yang, Fen‐Er Chen

ChemInform

DOI

2011

药物发现与合成途径

陈芬儿

2011

An efficient enantioselective synthesis of florfenicol via asymmetric aziridination

Zhonghua Wang, Feng Li, Lei Zhao, Qiuqin He, Fen‐Er Chen, Zheng Chen

Tetrahedron

DOI

2011

Chiral Squaramide‐Catalyzed Enantioselective Conjugate Michael Addition of Various Thiols to α,β‐Unsaturated N‐Acylated Oxazolidin‐2‐ones

Le Dai, Hongjun Yang, Fen‐Er Chen

European Journal of Organic Chemistry

DOI

2011

Efficient Asymmetric Synthesis of (2R,3R)-3-{(1R)-1-[tert-Butyl(dimethyl)-siloxy]ethyl}-4-oxoazetidin-2-yl Acetate

Fen‐Er Chen, Hui‐Fang Dai, Jianping Huang, Lei Zhao, Shuang‐Xi Gu, Zhonghua Wang, Hao Zhang

Synthesis

DOI

2011

Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1

Lei Zhao, Xiaodong Ma, Fen‐Er Chen

Organic Process Research & Development

DOI

2011

Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs

Shuang‐Xi Gu, Shiqiong Yang, Qiuqin He, Xiaodong Ma, Fen‐Er Chen, Hui‐Fang Dai, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2011

ChemInform Abstract: Synthetic Studies on (+)‐Biotin. Part 15. A Chiral Squaramide‐Mediated Enantioselective Alcoholysis Approach Toward the Total Synthesis of (+)‐Biotin (IV).

Xu‐Xiang Chen, Fei Xiong, Han Fu, Zhi‐Qian Liu, Fen‐Er Chen

ChemInform

DOI

2011

Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors

Xiao‐Dong Ma, Shi‐Qiong Yang, Shuang‐Xi Gu, Qiuqin He, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemMedChem

DOI

2011

Synthesis and biological evaluation of HQCAs with aryl or benzyl substituents on N-1 position as potential HIV-1 integrase inhibitors

Qiuqin He, Xuan Zhang, Hai-Qiu Wu, Shuang‐Xi Gu, Xiao-Dong Ma, Liu‐Meng Yang, Yong‐Tang Zheng, Fen‐Er Chen

Bioorganic & Medicinal Chemistry

DOI

2011

Synthesis and structure–activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs

Shuang‐Xi Gu, Qiuqin He, Shiqiong Yang, Xiaodong Ma, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2011

Synthesis and biological evaluation of (±)-benzhydrol derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Xiaodong Ma, Xuan Zhang, Shiqiong Yang, Hui‐Fang Dai, Liu‐Meng Yang, Shuang‐Xi Gu, Yong‐Tang Zheng, Qiuqin He, Fen‐Er Chen

Bioorganic & Medicinal Chemistry

DOI

2011

Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity

Qiuqin He, Shuang‐Xi Gu, Jia Liu, Hai-Qiu Wu, Xuan Zhang, Liu‐Meng Yang, Yong‐Tang Zheng, Fen‐Er Chen

Bioorganic & Medicinal Chemistry

DOI

2011

Synthesis and biological activity of naphthyl-substituted (B-ring) benzophenone derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Xiao-Dong Ma, Xuan Zhang, Hui‐Fang Dai, Shiqiong Yang, Liu‐Meng Yang, Shuang‐Xi Gu, Yong‐Tang Zheng, Qiuqin He, Fen‐Er Chen

Bioorganic & Medicinal Chemistry

DOI

2011

Synthesis and biological evaluation of naphthyl phenyl ethers (NPEs) as novel nonnucleoside HIV-1 reverse transcriptase inhibitors

Shuang‐Xi Gu, Xuan Zhang, Qiuqin He, Liu‐Meng Yang, Xiao-Dong Ma, Yong‐Tang Zheng, Shiqiong Yang, Fen‐Er Chen

Bioorganic & Medicinal Chemistry

DOI

2011

An efficient enantioselective synthesis of florfenicol via a vanadium-catalyzed asymmetric epoxidation

Feng Li, Zhonghua Wang, Lei Zhao, Fangjun Xiong, Qiuqin He, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2011

ChemInform Abstract: A Bifunctional Cinchona Alkaloid‐Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans‐Chalcones.

Le Dai, Suxi Wang, Fen‐Er Chen

ChemInform

DOI

2011

Synthetic Studies on (+)-Biotin, Part 15: A Chiral Squaramide-Mediated Enantioselective Alcoholysis Approach toward the Total Synthesis of (+)-Biotin

Xu‐Xiang Chen, Fei Xiong, Han Fu, Zhi‐Qian Liu, Fen‐Er Chen

Chemical and Pharmaceutical Bulletin

DOI

2010

HPLC法检测阿托伐他汀钙有关物质的含量及光学纯度

张亚平，杨淑莲，陈芬儿

《药物分析杂志》

2010

西地那非合成路线图解

戴惠芳，王红华，熊方均，陈芬儿

《中国医药工业杂志》

2010

A Bifunctional Cinchona Alkaloid‐Squaramide Catalyst for the Highly Enantioselective Conjugate Addition of Thiols to trans‐Chalcones

Le Dai, Suxi Wang, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2010

Synthetic Studies on Camptothecins. Part 3

Yunyan Kuang, Jingze Niu, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2010

An Efficient Method for Removal of Residual Palladium from Organic Solution of Faropenem Sodium in the Pd(II)-Catalyzed Cleavage of Allyl Faropenem

Jian-Ping Huang, Xu‐Xiang Chen, Shuang‐Xi Gu, Lei Zhao, Wenxue Chen, Fen‐Er Chen

Organic Process Research & Development

DOI

2010

Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy

Zhao‐Sen Zeng, Qiuqin He, Yonghong Liang, Xiaoqing Feng, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2010

A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin

Fei Xiong, Xu‐Xiang Chen, Zhi‐Qian Liu, Fen‐Er Chen

Tetrahedron Letters

DOI

2010

NMR studies on chiral intermediates in the total synthesis of (+)‐biotin from D ‐mannose

Wen‐xue Chen, Ping Zhang, Fen‐Er Chen

Magnetic Resonance in Chemistry

DOI

2010

Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors

Yonghong Liang, Qiuqin He, Zhao‐Sen Zeng, Zhi‐Qian Liu, Xiaoqing Feng, Fen‐Er Chen, Jan M. Balzarini, Christophe C. Pannecouque, Erik De Clercq

Bioorganic & Medicinal Chemistry

DOI

2010

An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide

Fei Xiong, Xu‐Xiang Chen, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2010

Lead Optimization of Diarylpyrimidines as Non‐nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

Zhao‐Sen Zeng, Yonghong Liang, Xiaoqing Feng, Fen‐Er Chen, Christophe C. Pannecouque, Jan M. Balzarini, Erik De Clercq

ChemMedChem

DOI

2010

Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV

Xiaoqing Feng, Zhao‐Sen Zeng, Yonghong Liang, Fen‐Er Chen, Christophe C. Pannecouque, Jan M. Balzarini, Erik De Clercq

Bioorganic & Medicinal Chemistry

DOI

2010

ChemInform Abstract: A Novel and Practical Synthesis of 2‐Amino‐5‐hydroxypropiophenone.

Xiaodong Xiong, Wenxue Chen, Yunyan Kuang, Fener Chen

ChemInform

DOI

2009

非核苷类逆转录酶抑制剂的研究XVⅢ:4-烯丙基和4-叠氮基取代的三嗪类化合物的合成及抗HIV活性(英文)

熊远珍，胡海荣，陈芬儿，Jan Balzarini，Christophe Pannecouque，Erik De Clercq

《药学学报》

2009

Design, Synthesis, and SAR of Naphthyl‐Substituted Diarylpyrimidines as Non‐Nucleoside Inhibitors of HIV‐1 Reverse Transcriptase

Yonghong Liang, Xiaoqing Feng, Zhao‐Sen Zeng, Fen‐Er Chen, Jan M. Balzarini, Christophe C. Pannecouque, Erik De Clercq

ChemMedChem

DOI

2009

A Novel Cost‐Effective Thiourea Bifunctional Organocatalyst for Highly Enantioselective Alcoholysis of meso‐Cyclic Anhydrides: Enhanced Enantioselectivity by Configuration Inversion

Suxi Wang, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2009

A Novel and Practical Synthesis of 2-Amino-5-hydroxypropiophenone

Xiaodong Xiong, Wenxue Chen, Yunyan Kuang, Fen‐Er Chen

Organic Preparations and Procedures International

DOI

2009

ChemInform Abstract: Copper‐ and Phosphine‐Free Sonogashira Coupling Reaction Catalyzed by Polyurea‐Encapsulated Palladium(II).

Yunyan Kuang, Fen‐Er Chen

ChemInform

DOI

2009

ChemInform Abstract: A Novel Cost‐Effective Thiourea Bifunctional Organocatalyst for Highly Enantioselective Alcoholysis of meso‐Cyclic Anhydrides: Enhanced Enantioselectivity by Configuration Inversion.

Suxi Wang, Fen‐Er Chen

ChemInform

DOI

2009

Unexpected Ring Expansion of the (3aS,6aR)‐γ‐Thiolactone Moiety during the Introduction of the (+)‐Biotin Side Chain

Jian Ming Huang, Fei Xiong, Zhong‐Hua Wang, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2009

Copper‐ and Phosphine‐Free Sonogashira Coupling Reaction Catalyzed by Polyurea‐Encapsulated Palladium(II)

Yunyan Kuang, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2009

Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 13

Yuan‐Zhen Xiong, Fen‐Er Chen, Jan M. Balzarini, Erik De Clercq, Christophe C. Pannecouque

Chemistry & Biodiversity

DOI

2008

5′（S）-1,1-亚乙二氧基-5-氧代-（5′-乙基-5′-羟基-2′H,5′H,6′H-6-氧代吡喃）-[3′,4′-f]-Δ6（8）-四氢中氮茚的合成研究

鲍勇，张立鹏，陈芬儿

《中国药物化学杂志》

2008

喜树碱及其类似物的Friedlander改进合成法

张立鹏，鲍勇，陈芬儿

《中国医药工业杂志》

2008

聚苯乙烯负载三氯化铁催化制备碳水化合物O-异亚丙基衍生物的改良方法

谢斌，陈芬儿

《中国药物化学杂志》

2008

以单糖为手性源的(+)-生物素立体选择性全合成研究进展

谢斌，陈芬儿

《中国药物化学杂志》

2008

Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors

Yueping Wang, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2008

Synthetic Studies on (+)‐Biotin, Part 11: Application of Cinchona Alkaloid‐Mediated Asymmetric Alcoholysis of meso‐Cyclic Anhydride in the Total Synthesis of (+)‐Biotin

Hui‐Fang Dai, Wenxue Chen, Lei Zhao, Fei Xiong, Hao Sheng, Fen‐Er Chen

Advanced Synthesis & Catalysis

DOI

2008

QSAR studies for diarylpyrimidines against HIV-1 reverse transcriptase wild-type and mutant strains

Yonghong Liang, Fen‐Er Chen

European Journal of Medicinal Chemistry

DOI

2008

Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity

Xiaoqing Feng, Yonghong Liang, Zhao‐Sen Zeng, Fen‐Er Chen, Jan M. Balzarini, Christophe C. Pannecouque, Erik De Clercq

ChemMedChem

DOI

2008

Synthetic Studies on Camptothecins. Part 1

Lipeng Zhang, Yong Bao, Yunyan Kuang, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2008

An Improved Convergent Strategy for the Synthesis of Oligoprenols

Xiongjie Yu, Hao Zhang, Fangjun Xiong, Xu‐Xiang Chen, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2008

ChemInform Abstract: Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 11. Structural Modulations of Diaryltriazines with Potent anti‐HIV Activity.

Yuan‐Zhen Xiong, Fen‐Er Chen, Jan M. Balzarini, Erik De Clercq, Christophe C. Pannecouque

ChemInform

DOI

2008

Solid-Phase Synthesis of Solanesol

Xiongjie Yu, Suxi Wang, Fen‐Er Chen

Journal of Combinatorial Chemistry

DOI

2008

Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy

Jian Ming Huang, Fei Xiong, Fen‐Er Chen

Tetrahedron Asymmetry

DOI

2008

Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Yueping Wang, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry

DOI

2008

Non‐Nucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 10

Yueping Wang, Fen‐Er Chen, Jan M. Balzarini, Erik De Clercq, Christophe C. Pannecouque

Chemistry & Biodiversity

DOI

2008

An improved acetonation method with the polystyrene-supported FeCl_3 as catalyst to the synthesis of O-isopropylidene carbohydrate derivatives

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2008

Synthesis of 5'(S)-1,1-dioxolane-5-oxo-(5'-ethyl-5'-hydroxyl-2'H,5'H,6'H-6-oxopyrano)-[3',4'-f]-Δ~(6(8))-tetrahydroindolizine

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2008

Research progress on stereospecific total synthesis of (+)-biotin starting from sugars as chiral pool

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2007

(2E,6E)-3,7-二甲基-8-羟基-2,6-辛二烯-1-醇乙酸酯的合成

黄建平，戴乐，张昊，陈芬儿

《沈阳药科大学学报》

2007

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: Structural modulations of diaryltriazines with potent anti-HIV activity

Yuan‐Zhen Xiong, Fen‐Er Chen, Jan M. Balzarini, Erik De Clercq, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2007

Synthesis and Anti-HIV-1 Activity Evaluation of 5-Alkyl-2-alkylthio-6-(arylcarbonyl or α-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Lei Ji, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Journal of Medicinal Chemistry

DOI

2007

Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 7. Synthesis, Antiviral Activity, and 3D‐QSAR Investigations of Novel 6‐(1‐Naphthoyl) HEPT Analogues.

Lei Ji, Fen‐Er Chen, Xiaoqing Feng, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2007

Novel Polymer‐Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes.

Suxi Wang, Fen‐Er Chen

ChemInform

DOI

2007

Synthesis and Molecular Structure of Ethyl [N-tosyl-(R)-prolyloxy]-2(S)-[4-cyano-8,8-ethylenedioxy-5-oxo-5,6,7,8-tetrahydroindolizin-3-yl] Acetate, a Key Intermediate in the Total Synthesis of (20S)-Camptothecins

Yunyan Kuang, Fen‐Er Chen

Molecules

DOI

2007

NMR Studies of a Series of Shikimic Acid Derivatives

Ping Zhang, Jian Ming Huang, Fen‐Er Chen

Journal of the Chinese Chemical Society

DOI

2007

(4R,5S)-Methyl 1,3-dibenzyl-5-[(R)-2-(hydroxydiphenylmethyl)pyrrolidine-1-carbonyl]-2-oxoimidazolidine-4-carboxylate

Jian Liu, Fen‐Er Chen, Min-Qin Chen

Acta Crystallographica Section E Structure Reports Online

DOI

2007

(4′S)-4′-Ethyl-3′,10′-dioxo-3′,4′,7′,8′-tetrahydrospiro[1,3-dioxolane-2,6′-1′H,6′H-pyrano[3,4-f]indolizin]-4′-ylN-(1-phenylethyl)carbamate

Yong Bao, Fen‐Er Chen, Min-Qin Chen

Acta Crystallographica Section E Structure Reports Online

DOI

2007

6-(2,6-Dichlorobenzyl)-5-ethyl-2-(4-methoxybenzylsulfanyl)pyrimidin-4(3H)-one

Yueping Wang, Fen‐Er Chen, Min-Qin Chen

Acta Crystallographica Section E Structure Reports Online

DOI

2007

An improved synthesis of a key intermediate for (+)-biotin from d-mannose

Fen‐Er Chen, Jianfeng Zhao, Fangjun Xiong, Bin Xie, Ping Zhang

Carbohydrate Research

DOI

2007

An Efficient Synthesis of a Potential (−)‐Reserpine Intermediate from (−)‐Shikimic Acid of the Chiral Pool

Jian Ming Huang, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2007

An Efficient and Green Oxidation of Vicinal Diols to Aldehydes Using Polymer‐Supported (Diacetoxyiodo)benzene as the Oxidant.

Fen‐Er Chen, Bin Xie, Ping Zhang, Jianfeng Zhao, Hui Wang, Lei Zhao

ChemInform

DOI

2007

Synthesis and anti‐HIV Activity Evaluation of 1‐[(Alkenyl or Alkynyl or Alkyloxy)methyl]‐5‐alkyl‐6‐(1‐naphthoyl)‐2,4‐pyrimidinediones as Novel Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors.

Lei Li, Fen‐Er Chen, Bin Xie, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2007

(3S,4S)-1-Benzhydryl-4-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-[(S)-1-hydroxyethyl]azetidin-2-one

Hao Zhang, Fen‐Er Chen, Min-Qin Chen

Acta Crystallographica Section E Structure Reports Online

DOI

2007

Synthetic Studies on Coenzyme Q10. Part 3

Xiongjie Yu, Hui‐Fang Dai, Fen‐Er Chen

Helvetica Chimica Acta

DOI

2007

(5R,6R)-Methyl 6-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate

Le Dai, Fen‐Er Chen, Min-Qin Chen

Acta Crystallographica Section E Structure Reports Online

DOI

2007

Novel Polymer-Supported Chiral Catalysts for the Asymmetric Addition of Diethylzinc to Aldehydes

Suxi Wang, Fen‐Er Chen

Chemical and Pharmaceutical Bulletin

DOI

2007

Synthesis of(2E,6E)-octadiene3,7-dimethyl-1,8 -diol-1-acetate

Fen‐Er Chen

Shenyang Yaoke Daxue xuebao

2006

8-氯-10,11-二氢-4-氮杂-5H-二苯并[a,d]-5-环庚酮的合成新方法

谢艳，吾国强，郑土才，陈芬儿

《中国药物化学杂志》

2006

DATA类逆转录酶抑制剂的三维定量构效关系

熊远珍，陈芬儿，冯筱晴

《化学学报》

2006

Trans-3-甲基-4-溴-2-丁烯基苄基醚的合成研究

黄建平，张招贵，陈芬儿

《江西化工》

2006

Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Lei Ji, Fen‐Er Chen, Bin Xie, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

European Journal of Medicinal Chemistry

DOI

2006

Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 7. Synthesis, Antiviral Activity, and 3D-QSAR Investigations of Novel 6-(1-Naphthoyl) HEPT Analogues

Lei Ji, Fen‐Er Chen, Xiaoqing Feng, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Chemical and Pharmaceutical Bulletin

DOI

2006

Practical and Phase Transfer Catalyzed Synthesis of 6‐Methoxytryptamine.

Yunyan Kuang, Jian Ming Huang, Fen‐Er Chen

ChemInform

DOI

2006

Synthetic Studies on Coenzyme Q10. Part 2

Hui‐Fang Dai, Fen‐Er Chen, Xiongjie Yu

Helvetica Chimica Acta

DOI

2006

Practical and Phase Transfer–Catalyzed Synthesis of 6‐Methoxytryptamine

Yunyan Kuang, Jian Ming Huang, Fen‐Er Chen

Synthetic Communications

DOI

2006

Non‐nucleoside HIV Reverse Transcriptase Inhibitors. Part 6. Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues.

Guang‐Fu Sun, Yunyan Kuang, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2005

10-去乙酰基-7-表紫杉醇转化为紫杉醇的研究(英文)

匡云艳，须媚，陈芬儿

《中国药物化学杂志》

2005

(E)-4-溴-3-甲基-2-丁烯酸的合成工艺改进(英文)

楚勇，路良，陈芬儿

《中国药物化学杂志》

2005

Synthetic Studies on d‐Biotin, Part 8:[1] An Efficient Chemoenzymatic Approach to the Asymmetric Total Synthesis of d‐Biotin via a Polymer‐Supported PLE‐Mediated Desymmetrization of meso‐Symmetic Dicarboxylic Esters

Fen‐Er Chen, Xu‐Xiang Chen, Hui‐Fang Dai, Yunyan Kuang, Bin Xie, Jianfeng Zhao

Advanced Synthesis & Catalysis

DOI

2005

Nonnucleoside HIV‐1 Reverse‐Transcriptase Inhibitors. Part 5. Synthesis and anti‐HIV‐1 Activity of Novel 6‐Naphthylthio HEPT Analogues.

Guang‐Fu Sun, Xu‐Xiang Chen, Fen‐Er Chen, Yue‐Ping Wang, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2005

Synthetic Studies on d‐Biotin. Part 9. An Improved Asymmetric Synthetic Route to d‐Biotin via Hoffmann—Roche Lactone—Thiolactone Approach.

Fen‐Er Chen, Hui‐Qing Jia, Xu‐Xiang Chen, Hui‐Fang Dai, Bin Xie, Yunyan Kuang, Jianfeng Zhao

ChemInform

DOI

2005

Non‐nucleoside HIV Reverse Transcriptase Inhibitors, Part 6[1]: Synthesis and Anti‐HIV Activity of Novel 2‐[(Arylcarbonylmethyl)thio]‐6‐arylthio DABO Analogues

Guang‐Fu Sun, Yunyan Kuang, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Archiv der Pharmazie

DOI

2005

Synthetic Studies on Coenzyme Q10

Xiongjie Yu, Fen‐Er Chen, Hui‐Fang Dai, Xu‐Xiang Chen, Yunyan Kuang, Bin Xie

Helvetica Chimica Acta

DOI

2005

Reserpine: A Challenge for Total Synthesis of Natural Products

Fen‐Er Chen, Jian Ming Huang

Chemical Reviews

DOI

2005

A Convenient and Efficient Asymmetric Synthesis of (S)‐α‐Arylthiomethyl‐α‐hydroxybutyric Acid Esters.

Yunyan Kuang, Fen‐Er Chen

ChemInform

DOI

2005

Synthesis of 1‐[(2‐Hydroxyethoxy)methyl] ‐6‐(5,6,7,8‐tetrahydronaphthylmethyl‐1)thymine as Novel Inhibitor Against Drug‐Resistant HIV Mutants.

Ge Meng, Yunyan Kuang, Lei Ji, Fen‐Er Chen

ChemInform

DOI

2005

Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors, Part 4[1]. Synthesis and Anti-HIV Activity of N-1-β-Carbonyl-6-naphthyl-methyl Analogues of HEPT

Yan‐Ping He, Yunyan Kuang, Fen‐Er Chen, Suxi Wang, Lei Ji, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Monatshefte für Chemie - Chemical Monthly

DOI

2005

A CONVENIENT AND EFFICIENT ASYMMETRIC SYNTHESIS OF (S)-α-ARYLTHIOMETHYL-α-HYDROXYBUTYRIC ACID ESTERS

Yunyan Kuang, Fen‐Er Chen

Organic Preparations and Procedures International

DOI

2005

Synthesis of 1‐[(2‐Hydroxyethoxy)Methyl]‐6‐(5,6,7,8‐Tetrahydronaphthylmethyl‐1)Thymine as Novel Inhibitor against Drug‐Resistant HIV Mutants

Ge Meng, Yunyan Kuang, Lei Ji, Fen‐Er Chen

Synthetic Communications

DOI

2005

A Novel and Convenient Synthesis of Coenzyme Q1.

Liang Lu, Fen‐Er Chen

ChemInform

DOI

2005

A Practical Procedure for the Synthesis of 3‐((E)‐5‐(2,3,4,5‐Tetramethoxy‐6‐methylphenyl)‐3‐methylpent‐3‐enyl) ‐2,2‐dimethyloxirane.

Yong Chu, Yunyan Kuang, Hui‐Fang Dai, Liang Lu, Fen‐Er Chen

ChemInform

DOI

2005

Nonnucleoside HIV-1 Reverse-Transcriptase Inhibitors, Part 5. Synthesis and Anti-HIV-1 Activity of Novel 6-Naphthylthio HEPT Analogues

Guang‐Fu Sun, Xu‐Xiang Chen, Fen‐Er Chen, Yue‐Ping Wang, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Chemical and Pharmaceutical Bulletin

DOI

2005

Synthetic Studies on d-Biotin, Part 9. An Improved Asymmetric Synthetic Route to d-Biotin via Hoffmann-Roche Lactone-Thiolactone Approach

Fen‐Er Chen, Hui-Qing Jia, Xu‐Xiang Chen, Hui‐Fang Dai, Bin Xie, Yun-Yan Kuang, Jian-Feng Zhao

Chemical and Pharmaceutical Bulletin

DOI

2005

Improved synthesis of (E)-4-bromo-3-methyl-2-butenoic acid

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2004

HEPT类HIV-1逆转录酶抑制剂的研究进展

孟歌，陈芬儿

《中国药物化学杂志》

2004

A Novel and Convenient Synthesis of Coenzyme Q1

Liang Lu, Fen‐Er Chen

Synthetic Communications

DOI

2004

A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction—Sulfenylation Reaction.

Guang‐Fu Sun, Yunyan Kuang, Suxi Wang, Fen‐Er Chen

ChemInform

DOI

2004

A PRACTICAL PROCEDURE FOR THE SYNTHESIS OF 3-((E)-5-(2,3,4,5-TETRAMETHOXY-6-METHYLPHENYL)-3METHYLPENT-3-ENYL)-2,2-DIMETHYLOXIRANE

Yong Chu, Yunyan Kuang, Hui‐Fang Dai, Liang Lu, Fen‐Er Chen

Organic Preparations and Procedures International

DOI

2004

5‐Alkyl‐2‐[(aryl and alkyloxycarbonylmethyl)thio]‐6‐(1‐naphthylmethyl) Pyrimidin‐4(3H)‐ones as an Unique HIV Reverse Transcriptase Inhibitors of S‐DABO Series.

Yan‐Ping He, Fen‐Er Chen, Guang‐Fu Sun, Yueping Wang, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2004

A Novel and Simple Synthesis of (1S,2S)‐2‐Amino‐1‐(p‐nitrophenyl)‐3‐trityloxypropanol.

Jian‐Li Yuan, Hui‐Fen Dai, Fen‐Er Chen

ChemInform

DOI

2004

Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones

Yan‐Ping He, Fen‐Er Chen, Xiongjie Yu, Yueping Wang, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic Chemistry

DOI

2004

PRACTICAL ROUTE TO A β-KETOPHOSPHONATE, A KEY INTERMEDIATE FOR THE TOTAL SYNTHESIS OF 20(S)-CPT AND RELATED ANALOGUES

Ming Huo, Yunyan Kuang, Fen‐Er Chen

Organic Preparations and Procedures International

DOI

2004

A Simple and Convenient Synthesis of HEPT Analogues via a One‐Pot Reduction–Sulfenylation Reaction

Guang‐Fu Sun, Yunyan Kuang, Suxi Wang, Fen‐Er Chen

Synthetic Communications

DOI

2004

3-Bromomethyl-3-ethyl-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]oxazine-1,4-dione

Yunyan Kuang, Ming Huo, Fen‐Er Chen

Acta Crystallographica Section C Crystal Structure Communications

DOI

2004

5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series

Yan‐Ping He, Fen‐Er Chen, Guang‐Fu Sun, Yueping Wang, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Bioorganic & Medicinal Chemistry Letters

DOI

2004

A Selective and Mild Oxidation of Primary Amines to Nitriles with Trichloroisocyanuric Acid.

Fen‐Er Chen, Yunyan Kuang, Hui‐Fang Dai, Liang Lu, Ming Huo

ChemInform

DOI

2004

Synthetic Studies on d‐Biotin. Part 6. An Expeditious and Enantiocontrolled Approach to the Total Synthesis of d‐Biotin via a Polymer‐Supported Chiral Oxazaborolidine‐Catalyzed Reduction of meso‐Cyclic Imide.

Fen‐Er Chen, Jian‐Li Yuan, Hui‐Fang Dai, Yunyan Kuang, Yong Chu

ChemInform

DOI

2004

Research progress of HEPT analogs as nonnucleoside HIV-1 reverse transcriptase inhibitors

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2004

Practical Route to a β‐Ketophosphonate, a Key Intermediate for the Total Synthesis of 20(S)‐CPT and Related Analogues.

Ming Huo, Yunyan Kuang, Fener Chen

ChemInform

DOI

2004

A NOVEL AND SIMPLE SYNTHESIS OF (1S, 2S)-2-AMINO-l-(p-NITROPHENYL)-3-TRITYLOXYPROPANOL

Jian‐Li Yuan, Hui‐Fen Dai, Fener Chen

Organic Preparations and Procedures International

DOI

2003

非核苷类HIV-1逆转录酶抑制剂Ⅱ6-(1-萘甲基)胸腺嘧啶类化合物三维定量构效关系

孟歌，陈芬儿

《中国药物化学杂志》

2003

芳构酶抑制剂7α-取代雄甾二酮三维定量构效关系的研究

何严萍，楚勇，陈芬儿

《中国药物化学杂志》

2003

酮基布洛芬的合成方法改进

余红霞，郭峰，陈芬儿

《中国药物化学杂志》

2003

溴甲基环丁烷的合成方法改进

戴惠芳，刘朝晖，李南，谢斌，陈芬儿

《中国药物化学杂志》

2003

紫杉醇、三尖杉宁碱和7-表-10-去乙酰基紫杉醇的分离及7-表-紫杉醇的转化研究

戴惠芳，梅忠，须媚，陈芬儿

《中国药物化学杂志》

2003

Nonnucleoside HIV-1 reverse transcriptase inhibitors I 3D-QSAR study on 6-(1-naphthylmethyl)substituted thymines

Fen‐Er Chen

Zhongguo yaowu huaxue zazhi

2003

Nonnucleoside HIV‐1 Reverse Transcriptase Inhibitors. Part 1. Synthesis and Structure—Activity Relationship of 1‐Alkoxymethyl‐5‐alkyl‐6‐naphthylmethyl Uracils as HEPT Analogues.

Ge Meng, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

ChemInform

DOI

2003

Synthetic studies on d-biotin. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine

Fen‐Er Chen, Hui‐Fang Dai, Yunyan Kuang, Hui-Qing Jia

Tetrahedron Asymmetry

DOI

2003

Hypophosphorous Acid‐Iodine: An Efficient and Mild Reagent for Cleavage of N—C Bond.

Ge Meng, Yan‐Ping He, Fen‐Er Chen

ChemInform

DOI

2003

Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 12. A Convenient and Practical Procedure for the Selective Oxidation of Thiols to Disulfides with Tetrabutylammonium Peroxydisulfate under Solvent‐Free Conditions.

Fen‐Er Chen, Yun‐Wen Lu, Yan‐Ping He, Youfu Luo, Ming‐Guo Yan

ChemInform

DOI

2003

Hypophosphorous Acid-Iodine: An Efficient and Mild Reagent for Cleavage of N–C Bond

Ge Meng, Yan‐Ping He, Fen‐Er Chen

Synthetic Communications

DOI

2003

Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors: Part I. Synthesis and Structure-Activity Relationship of 1-Alkoxymethyl-5-alkyl-6-naphthylmethyl Uracils as HEPT Analogues

Ge Meng, Fen‐Er Chen, Erik De Clercq, Jan M. Balzarini, Christophe C. Pannecouque

Chemical and Pharmaceutical Bulletin

DOI

2002

去羟肌苷的化学合成路线图解

卢云雯，陈芬儿

《中国医药工业杂志》

2002

甾体类芳香酶抑制剂的构效关系与研究进展

何严萍，陈芬儿

《中国药物化学杂志》

2002

19-取代雄烯二酮芳构酶抑制剂的定量构效关系研究

许辽萨，何严萍，李振华，王文宁，范康年，陈芬儿

《化学学报》

2002

1-[(乙氧基)甲基]-6-(1-萘甲基)胸腺嘧啶的合成

罗有福，孟歌，陈芬儿

《广州化学》

2002

Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 13. A Simple and Highly Efficient One‐Pot Synthesis of Nitriles by Nickel‐Catalyzed Oxidation of Primary Alcohols with Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Yong‐Ye Li, Mei Ling Xu, Hui‐Qing Jia

ChemInform

DOI

2002

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 11. A Novel and Selective Approach to the Oxidative Deprotection of Allyl Ethers with Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Xiou‐Hong Ling, Yan‐Ping He, Xiaohua Peng

ChemInform

DOI

2002

TETRABUTYLAMMONIUM PEROXYDISULFATE IN ORGANIC SYNTHESIS. XII.[1] A CONVENIENT AND PRACTICAL PROCEDURE FOR THE SELECTIVE OXIDATION OF THIOLS TO DISULFIDES WITH TETRABUTYLAMMONIUM PEROXYDISULFATE UNDER SOLVENT-FREE CONDITIONS

Fen‐Er Chen, Yun‐Wen Lu, Yan‐Ping He, Youfu Luo, Ming‐Guo Yan

Synthetic Communications

DOI

2001

扎托洛芬的合成路线图解

彭小华，陈芬儿

《中国医药工业杂志》

2001

ChemInform Abstract: An Efficient and Enantioselective Synthesis of d‐Biotin.

Fen‐Er Chen, Yaodong Huang, Han Fu, Yu Cheng, Daoming Zhang, Yong‐Ye Li, Zuo‐Zong Peng

ChemInform

DOI

2001

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 10. An Efficient Nickel‐Catalyzed One‐Pot Synthesis of Nitriles from Aldehydes by Oxidation with Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Han Fu, Ge Meng, Yu Cheng, Yinxiang Lu

ChemInform

DOI

2001

ChemInform Abstract: A Practical Synthesis of (3aα,6aα)‐1,3‐Dibenzylhexahydro‐1H‐thieno [3,4‐d]imidazol‐2(3H)‐one.

Fener Chen, Ge Meng, Yan‐Ping He, Yu Cheng, Xiu‐Hong Ling

ChemInform

DOI

2001

A PRACTICAL SYNTHESIS OF (3aα, 6aα)-1,3-DIBENZYL HEXAHYDRO-1H-THIENO[3,4-d]IMIDAZOL-2(3H)-ONE

Fener Chen, Ge Meng, Yan‐Ping He, Yu Cheng, Xiu‐Hong Ling

Organic Preparations and Procedures International

DOI

2000

四正丁基过硫酸铵氧化裂解2,4-二硝基苯腙衍生物的反应研究

陈芬儿，严琼娇，彭作中，张道明，傅晗，刘继东

《有机化学》

2000

洛索洛芬钠合成工艺研究 Ⅱ.高区域选择性烷基化合成法

陈芬儿，严琼娇，刘明星，邵兰英，户业丽

《中国医药工业杂志》

2000

S—酮基布洛芬的合成研究进展

黄毕生，陈芬儿

《大理大学学报》

2000

酮康唑缩合工艺改进

程煜，陈芬儿

《中国药科大学学报》

2000

Tetrabutylammonium Peroxydisulfate in Organic Synthesis; IX: A Convenient Approach to the Synthesis of Fused Acetal Derivatives by Tetrabutylammonium Peroxydisulfate-Mediated Oxidative Cycloaddition of 1,3-Dicarbonyl Compounds to Cyclic Enol Ethers

Fen‐Er Chen, Fu Han, Ge Meng, Yu Cheng, Ye‐Li Hu

Synthesis

DOI

2000

An Efficient and Enantioselective Synthesis of d-Biotin

Fen‐Er Chen, Yaodong Huang, Han Fu, Yu Cheng, Daoming Zhang, Yong‐Ye Li, Zuo‐Zong Peng

Synthesis

DOI

2000

Tetrabutylammoninm Peroxydisulfate in Organic Synthesis X. An Efficient Nickel-Catalyzed One-Pot Synthesis of Nitriles from Aldehydes by Oxidation with Tetrabutylammonium Peroxydisulfate

Fen‐Er Chen, Han Fu, Ge Meng, Yu Cheng, Yinxiang Lu

Synthesis

DOI

2000

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 9. A Convenient Approach to the Synthesis of Fused Acetal Derivatives by Tetrabutylammonium Peroxydisulfate Mediated Oxidative Cycloaddition of 1,3‐Dicarbonyl Compounds to Cyclic Enol Ethers.

Fen‐Er Chen, Han Fu, Ge Meng, Yu Cheng, Ye‐Li Hu

ChemInform

DOI

2000

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 7. A Facile and Efficient Method for the Regeneration of Carbonyl Compounds from Semicarbazones by Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Ji‐Dong Liu, Han Fu, Zhuo‐Zhong Peng, Lanying Shao

ChemInform

DOI

2000

ChemInform Abstract: A Novel and Efficient Method for the Oxidative Removal of O‐Benzyl Protective Groups of Carbohydrates by Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Zuozhong Peng, Han Fu, Ge Meng, Yu Cheng, Yin‐Xiang Lue

ChemInform

DOI

2000

Tetrabutylammonium Peroxydisulfate in Organic Synthesis; VII. a Facile and Efficient Method for the Regeneration of Carbonyl Compounds from Semicarbazones by Tetrabutylammonium Peroxydisulfate

Fen‐Er Chen, Ji‐Dong Liu, Han Fu, Zuozhong Peng, Lanying Shao

Synthetic Communications

DOI

2000

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 8. An Efficient and Convenient Nickel‐Catalyzed Oxidation of Primary Amines to Nitriles with Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Zuozhong Peng, Han Fu, Ji‐Dong Liu, Lanying Shao

ChemInform

DOI

2000

ChemInform Abstract: Antiinflammatory Drugs of 2‐Arylpropanoic Acids. Part 9. A Practical Synthesis of Ketoprofen by 1,2‐Aryl Rearrangement.

Fen‐Er Chen, Ji‐Dong Liu, Lanying Shao, Qiongjiao Yan

ChemInform

DOI

1999

D296树脂分散钯催化氢转移反应的研究──Ⅰ.取代芳香硝基化合物的还原

陈芬儿，严琼娇，邵兰英，刘明星

《离子交换与吸附》

1999

有机药物合成法. 第1卷

陈芬儿

《中国医药科技出版社》

1999

Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 8. 1 An Efficient and Convenient Nickel-catalyzed Oxidation of Primary Amines to Nitriles with Tetrabutylammonium Peroxydisulfate

Fen‐Er Chen, Zuozhong Peng, Fu Han, Ji‐Dong Liu, Lanying Shao

Journal of Chemical Research

DOI

1999

ChemInform Abstract: Tetrabutylammonium Peroxydisulfate in Organic Synthesis. Part 4. An Efficient, Highly Selective and Oxidative Deoximation by Tetrabutylammonium Peroxydisulfate.

Fen‐Er Chen, Anchang Liu, Qiongjiao Yan, Mingxing Liu, Daoming Zhang, Lanying Shao

ChemInform

DOI

1999

Tetrabutylammonium Peroxydisulfate in Organic Synthesis; IV.1An Efficient, Highly Selective and Oxidative Deoximation by Tetrabutylammonium Peroxydisulfate

Fen‐Er Chen, Anchang Liu, Qiongjiao Yan, Mingxing Liu, Daoming Zhang, Lanying Shao

Synthetic Communications

DOI

1998

双氯芬酸钠合成工艺研究 Ⅱ.取代乙酰苯胺重排法

陈芬儿，邓燕，户业丽，万江陵

《中国医药工业杂志》

1998

洛索洛芬钠的重排合成工艺研究

陈芬儿，刘安昌，户业丽，刘明星，管春生

《中国医药工业杂志》

1998

碘重排法合成酮基布洛芬

户业丽，凌秀红，陈芬儿

《中国药物化学杂志》

1998

水杨酸醚化反应工艺

户业丽，管春生，陈芬儿

《武汉工程大学学报》

1998

相转移催化法合成间硝基苯甲醚

户业丽，管春生，陈芬儿

《中南民族大学学报(自然科学版)》

1998

聚苯乙烯固载聚乙二醇催化合成β-萘乙醚

管春生，户业丽，陈芬儿

《化学与生物工程》

1998

聚乙二醇催化合成间硝基茴香醚的研究

管春生，户业丽，陈芬儿

《化学与生物工程》

1997

dl-萘普生重排合成的工艺研究VΔ

陈芬儿，管春生，户业丽，冯秀梅，谢斌，凌秀红

《中国医药工业杂志》

1997

2-芳基丙酸类消炎镇痛药物的研究──6　1,2-芳基重排法合成苯氧布洛芬钙

马丽芳，唐维高，彭崇莹，陈芬儿

《华西药学杂志》

1997

2-芳基丙酸类消炎镇痛药物的研究──7用1,2-芳基重排法合成酮基布洛芬

管春生，陈芬儿

《华西药学杂志》

1997

2,6-二氯苯酚合成工艺研究

管春生，陈芬儿，张珩

《武汉工程大学学报》

1996

2—(α—溴丙酰)—6—萘甲醚的合成工艺研究

杨建设，张珩，陈芬儿

《药学研究》

1995

2,6——二氯苯酚的合成方法

张珩，杨建设，万江陵，管春生，陈芬儿

《药学研究》

1995

基础药物设计学

陈芬儿

《华中理工大学出版社》

1993

蝙蝠葛生物碱综合利用研究——Ⅱ.蝙蝠葛副碱的成份分离与鉴定

潘锡平，李学军，陈业文，陈芬儿

《天然产物研究与开发》

1993

1,4—二氢吡啶类钙拮抗剂的合成法研究——(Ⅰ)尼群地平改进合成工艺

陈芬儿，沈怡，李艳

《武汉工程大学学报》

1993

1,4-二氢吡啶类钙拮抗剂的合成法研究——(Ⅱ)尼莫地平的合成新方法

陈芬儿，李艳，沈怡，谌英武

《武汉工程大学学报》

1992

dl-萘普生重排合成的工艺研究

陈芬儿，董恩莲，邵兰英

《中国医药工业杂志》

1992

布洛芬的重排法合成工艺研究

陈芬儿，尤彩芬，潘锡平，顾小曼

《中国医药工业杂志》

1992

酮洛芬的改进合成法

陈芬儿，张文文，董恩莲

《中国医药工业杂志》

1992

二环己基碳二亚胺制备方法的改进

陈芬儿

《化学试剂》

1991

离子交换树脂支载的硼氢化物还原羰基

胡谋刚，陈静，陈芬儿，陈家威

《中国医药工业杂志》

1991

布洛芬的氰烷基化合成法

陈芬儿，袁巍

《中国医药工业杂志》

1991

酮基布洛芬的合成

陈芬儿，张文文

《中国医药工业杂志》

1991

N—羟乙基—乙二胺的合成研究

殷斌烈，陈芬儿，倪风雪，陈杰河

《精细化工中间体》

1991

抗球虫药尼卡巴嗪的应用及合成工艺研究

殷斌烈，陈芬儿，刘桂桂，张珩，刘敛飞，李少进

《化学与生物工程》

1990

萘普生的重排法合成

陈芬儿，刘汉生，李淑平

《中国医药工业杂志》

1990

镇静催眠药阿普唑仑的合成

陈芬儿，刘兴勤

《中国医药工业杂志》

1990

农药中间体呋喃酚合成研究(Ⅱ)

陈芬儿，冯元志，邹青

《化学与生物工程》

1990

相转移催化法合成水杨酸

陈芬儿

《染料与染色》

1990

合成邻氯苯乙酸的改进方法

陈芬儿，冯远志，张衍，杨艺虹

《华西药学杂志》

1990

直接羧烷基化法合成萘普生

陈芬儿，冯远志，周冰，张衡，李淑平

《中国现代应用药学》

1989

芪甲酸类化合物的合成及其对HL-60细胞增殖的影响

陈芬儿，胥佩菱

《华西药学杂志》

1989

相转移催化合成3-氯4-氟硝基苯的改进

陈芬儿，刘兴勤，李淑平

《华西药学杂志》

1988

农药中间体呋喃酚的合成研究(Ⅰ)

陈芬儿

《化学与生物工程》

1988

B—(3.4—二甲氧基苯基)乙基胺合成

陈芬儿

《武汉工程大学学报》

会议论文

2018

他汀类降血脂原料药不对称合成-从化学动力学拆分到不对称催化技术的演化

陈芬儿

《中国化学会·第十五届全国有机合成化学学术研讨会》

DOI

2018

Targeting at the crooked nonnucleoside binding pocket of HIV-1 reverse transcriptase

Ge Meng, Erik De Clercq, Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Asymmetric synthesis of HMG-CoA reductase inhibitors(statins)——Evolution of synthetic strategies to streamlined process

Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Optimization of N2,N4-disubstituted quinazoline-2,4-diamines with improved potency against K103 N mutant and rilpivirine-resistant E138K mutant as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Sheng Han, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

3D-QSAR study on Meridianin derivatives as glycogen synthase kinase-3 inhibitor against type Ⅱ diabetes

Shuwen Han, Ge Meng, Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors:optimizing diarylpyrimidines with a connecting arm of cyano group

Tingting Li, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors:optimizing diarylpyrimidines targeting at W229 and F227

Yali Sang, Tingting Li, Erik De Clercq, Christophe Pannecouque, Ge Meng, Fener Chen

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2015

喜树碱类原料药的不对称化学全合成研究

陈芬儿

《中国化学会第九届全国有机化学学术会议论文摘要集（1）》

2014

喜树碱类原料药的不对称化学全合研究

陈芬儿

《中国化学会第十届全国天然有机化学学术会议论文集——第二分会场：天然产物全合成和结构修饰》

2013

瑞舒伐他汀高立体选择性合成新工艺研究——我们的研发之路

陈芬儿，熊方均，陈晓飞

《2013年全国药物化学学术会议暨第四届中英药物化学学术会议》

2010

(+)-生物素的不对称全合成研究

陈芬儿

《中国化学会第八届天然有机化学学术研讨会论文集》

2008

(+)-喜树碱类药物的不对称全合成研究

汪忠华，熊小东，熊方均，陈芬儿

《第七届全国天然有机化学学术研讨会》

2004

抗爱滋病新药5-Isopropyl-6-(1-naphthylmethyl)-1-(2-oxo-2-p-tolyl-ethyI)uracil结构的NMR研究

王力平，邵倩芬，何严萍，陈芬儿

《第十三届全国波谱学学术会议论文摘要集》

预印本

2025

Achiral NaI and 2-Mercaptobenzimidazole as Chiral Modulators for Stereodivergent Synthesis of Azanucleosides

Fen‐Er Chen, Yangyang Zhong, Jie Zeng, Mingwei Li, Yuli Liang, Kehan Zhao, Jiayi Mu, Shuman Guan, Pei Tang, Huijing Wang

Research Square

DOI

2021

Highly accurate prediction of reaction performance and enantioselectivity with a uniform machine learning protocol

Xiaofei Sun, Jingyuan Zhu, Hengzhi You, Bin Chen, Fen‐Er Chen

Research Square

DOI

书籍章节

2023

Asymmetric Baeyer-Villiger Oxidation

Fen‐Er Chen, Hengzhi You

Elsevier eBooks

DOI

研究方向

计算机辅助药物发现与作用机制研究天然产物全合成不对称催化与手性药物

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