龚庆国｜中国科学技术大学｜学者主页

2026

Structure-driven RNA remodeling underlies broad substrate recognition by NSUN2.

Qian Hu, Wen Yang, Y. Yu, Ran Yi, Yu-Tong Zhang, Leyuan Duan, Fudong Li, Kai-Ming Zhang, Qingguo Gong, Shanshan Li

Science China Life Sciences

DOI

2026

Structural insights into the assembly and function of Retron Ec78 PtuAB

Leyuan Duan, Lu-Guang Chen, Qian Hu, Xiao Li, Shan-Shan Li, Kai-Ming Zhang, Qingguo Gong

Communications Biology

DOI

2026

Structural insights into the recognition and catalysis of tRNA by human NSUN2

Qian Hu, Wen Yang, Y. Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Lei Wang, Fudong Li, Kai-Ming Zhang, Qingguo Gong, Shanshan Li

bioRxiv

DOI

2025

Structural insights into dynamics of the BMV TLS aminoacylation

Wen Yang, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kai-Ming Zhang

Nature Communications

DOI

2024

Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis

Ming Li, Hongwei Liu, K. Hsieh, Shengchun Zhang, Yongxiang Gao, Qingguo Gong, Kai-Ming Zhang, Chung-I Chang, Shan-Shan Li

Fundamental Research

DOI

2024

Elucidating the Architectural dynamics of MuB filaments in bacteriophage Mu DNA transposition

Xiao-Long Zhao, Yongxiang Gao, Qingguo Gong, Kai-Ming Zhang, Shan-Shan Li

Nature Communications

DOI

2024

Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1.

Yumi Xuan, Lei Wang, Liang Zhang, Meng-Qi Lv, Fudong Li, Qingguo Gong

Biochemical and Biophysical Research Communications - BBRC

DOI

2022

Structural basis for Gemin5 decamer-mediated mRNA binding

Qiong Guo, Shidong Zhao, Rosario Francisco‐Velilla, Jiahai Zhang, Azman Embarc Buh, Salvador Abellan, Mengqi Lv, Pei‐Ping Tang, Qingguo Gong, Huaizong Shen, Linfeng Sun, Xuebiao Yao, Jinrong Min, Yunyu Shi, Encarnación Martı́nez-Salas, Kaiming Zhang, Chao Xu

Nature Communications

DOI

2020

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

Jessica L Kelliher, Kirk L. West, Qingguo Gong, Justin W. C. Leung

Nature Communications

DOI

2020

Crystal structure of Arabidopsis terminal uridylyl transferase URT1

Lingru Zhu, Qian Jin Hu, Lin Cheng, Yiyang Jiang, Mengqi Lv, Yongrui Liu, Fudong Li, Yunyu Shi, Qingguo Gong

Biochemical and Biophysical Research Communications

DOI

2019

Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function

Xiaodan Liu, Shengqi Shen, Pengzhi Wu, Fudong Li, Xing Liu, Chongyuan Wang, Qingguo Gong, Jihui Wu, Xuebiao Yao, Huafeng Zhang, Yunyu Shi

Nucleic Acids Research

DOI

2019

Crystal Structure of Urate Oxidase from Bacillus Subtilis 168

Anam Nayab, Sayed Ala Moududee, Yi Shi, Yong‐Liang Jiang, Qingguo Gong

Crystallography Reports

DOI

2019

Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering

Xinyao Hu, Xuanling Li, Lingna Yang, Yilin Zhu, Yunyu Shi, Yinmei Li, Haowei Wang, Qingguo Gong

PLoS ONE

DOI

2018

二聚体RNA解旋酶CsdA的结构生物学研究及其C端区域的重要功能

Ling Xu, Lijun Wang, Junhui Peng, Fudong Li, Lijie Wu, Beibei Zhang, Mengqi Lv, Jiahai Zhang, Qingguo Gong, Rongguang Zhang, Xiaobing Zuo, Zhiyong Zhang, Jihui Wu, 唐雅珺, 施蕴渝

《科学新闻》

2018

Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation inDrosophila

Mengqi Lv, Yixiang Yao, Fudong Li, Ling Xu, Lingna Yang, Qingguo Gong, Yong-Zhen Xu, Yunyu Shi, Yujie Fan, Yajun Tang

Nucleic Acids Research

DOI

2018

Structural insights into a unique preference for 3′ terminal guanine of mirtron inDrosophilaTUTase tailor

Lin Cheng, Fudong Li, Yiyang Jiang, Hailong Yu, Changlin Xie, Yunyu Shi, Qingguo Gong

Nucleic Acids Research

DOI

2018

Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase

Sayed Ala Moududee, Yiyang Jiang, Gilbert Nshogoza, Guodong Xie, Zheng Xu, Jihui Wu, Qingguo Gong, Yajun Tang, Yunyu Shi

Protein Science

DOI

2018

Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy

Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang, Ke Ruan

The Journal of Physical Chemistry Letters

DOI

2018

Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD

Yiyang Jiang, Hailong Yu, Fudong Li, Lin Cheng, Lingru Zhu, Yunyu Shi, Qingguo Gong

PLoS Pathogens

DOI

2018

Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII

Tianrong Hang, Xiaozhen Zhang, Xiaozhen Zhang, Minhao Wu, Chengliang Wang, Shenglong Ling, Ling Xu, Qingguo Gong, Changlin Tian, Xuan Zhang, Xuan Zhang, Jianye Zang

Biochemical and Biophysical Research Communications

DOI

2017

Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions

Ling Xu, Lijun Wang, Junhui Peng, Fudong Li, Lijie Wu, Beibei Zhang, Mengqi Lv, Jiahai Zhang, Qingguo Gong, Rongguang Zhang, Xiaobing Zuo, Zhiyong Zhang, Jihui Wu, Yajun Tang, Yunyu Shi

Structure

DOI

2017

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity

Lingna Yang, Chongyuan Wang, Fudong Li, Jiahai Zhang, Anam Nayab, Jihui Wu, Yunyu Shi, Qingguo Gong

Journal of Biological Chemistry

DOI

2017

The important conformational plasticity of DsrA sRNA for adapting multiple target regulation

Pengzhi Wu, Xiaodan Liu, Lingna Yang, Yitong Sun, Qingguo Gong, Jihui Wu, Yunyu Shi

Nucleic Acids Research

DOI

2017

Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals

Yufei Yang, ShengQi Xiang, Xiaodan Liu, Xiaojing Pei, Pengzhi Wu, Qingguo Gong, Na Li, Marc Baldus, Shenlin Wang

Chemical Communications

DOI

2017

Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies

Bin Wen, Weiwei Wang, Jiahai Zhang, Qingguo Gong, Yunyu Shi, Jihui Wu, Zhiyong Zhang

Physical Chemistry Chemical Physics

DOI

2017

Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation

Xiaoling Bao, Heng Liu, Xing Liu, Ke Ruan, Yonghui Zhang, Zhiyong Zhang, Qi Hu, Ying Liu, Saima Akram, Jiahai Zhang, Qingguo Gong, Wenwen Wang, Xiao Ni Yuan, Jian Li, Lingli Zhao, Zhen Dou, Ruijun Tian, Xuebiao Yao, Jihui Wu, Yunyu Shi

Journal of Molecular Cell Biology

DOI

2017

Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD

Yiyang Jiang, Fudong Li, Jihui Wu, Yunyu Shi, Qingguo Gong

PLoS ONE

DOI

2015

Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations

Yonghui Zhang, Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang

Protein & Cell

DOI

2015

Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq

Lijun Wang, Weiwei Wang, Fudong Li, Jiahai Zhang, Jihui Wu, Qingguo Gong, Yunyu Shi

Nucleic Acids Research

DOI

2014

Characterization of Protein Flexibility Using Small-Angle X-Ray Scattering and Amplified Collective Motion Simulations

Bin Wen, Junhui Peng, Xiaobing Zuo, Qingguo Gong, Zhiyong Zhang

Biophysical Journal

DOI

2014

Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7

Chongyuan Wang, Yuwei Zhu, Tamar B. Cáceres, Lei Liu, Junhui Peng, Junchen Wang, Jiajing Chen, Xuwen Chen, Zhiyong Zhang, Xiaobing Zuo, Qingguo Gong, Maikun Teng, Joan M. Hevel, Jihui Wu, Yunyu Shi

Structure

DOI

2014

Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding

Juncheng Wang, Qin Su, Fudong Li, Sai Li, Wei Zhang, Junhui Peng, Zhiyong Zhang, Qingguo Gong, Jihui Wu, Yunyu Shi

Cell Research

DOI

2014

Crystal structure of triple‐BRCT‐domain of ECT2 and insights into the binding characteristics to CYK‐4

Yang Zou, Zhenhua Shao, Junhui Peng, Fudong Li, Deshun Gong, Chongyuan Wang, Xiaobing Zuo, Zhiyong Zhang, Jihui Wu, Yunyu Shi, Qingguo Gong

FEBS Letters

DOI

2014

Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin

Debiao Zhao, Xuejuan Wang, Junhui Peng, Chongyuan Wang, Fudong Li, Qianqian Sun, Yibo Zhang, Jiahai Zhang, Gang Cai, Xiaobing Zuo, Jihui Wu, Yunyu Shi, Zhiyong Zhang, Qingguo Gong

Journal of Structural Biology

DOI

2014

Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei

Chongyuan Wang, Yuwei Zhu, Jiajia Chen, Xu Li, Junhui Peng, Jiajing Chen, Yang Zou, Zhiyong Zhang, Jin Hong, Pengyuan Yang, Jihui Wu, Liwen Niu, Qingguo Gong, Maikun Teng, Yunyu Shi

PLoS ONE

DOI

2013

大肠杆菌RNA分子伴侣Hfq与DsrA和rpoS作用机制的研究进展

王丽君，王维维，龚庆国，吴季辉，施蕴渝

《生物化学与生物物理进展》

2013

Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA

Weiwei Wang, Lijun Wang, Jihui Wu, Qingguo Gong, Yunyu Shi

Nucleic Acids Research

DOI

2013

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

Zhenhua Shao, Wei Xing Yan, Junhui Peng, Xiaobing Zuo, Yang Zou, Fudong Li, Deshun Gong, Rongsheng Ma, Jihui Wu, Yunyu Shi, Zhiyong Zhang, Maikun Teng, Xu Li, Qingguo Gong

Nucleic Acids Research

DOI

2012

Solution Structure of the Second RRM Domain of RBM5 and Its Unusual Binding Characters for Different RNA Targets

Zhenwei Song, Peiwen Wu, Peng Ji, Jiahai Zhang, Qingguo Gong, Jihui Wu, Yunyu Shi

Biochemistry

DOI

2012

Identification and structural basis for a novel interaction between Vav2 and Arap3

Bo Wu, Fengsong Wang, Jiahai Zhang, Zhiyong Zhang, Liying Qin, Junhui Peng, Fudong Li, Jianping Liu, Guowei Lü, Qingguo Gong, Xuebiao Yao, Jihui Wu, Yunyu Shi

Journal of Structural Biology

DOI

2011

Solution Structure of Tandem SH2 Domains from Spt6 Protein and Their Binding to the Phosphorylated RNA Polymerase II C-terminal Domain

Jianping Liu, Jiahai Zhang, Qingguo Gong, Peng Xiong, Hongda Huang, Bo Wu, Guowei Lü, Guowei Lü, Jihui Wu, Yunyu Shi

Journal of Biological Chemistry

DOI

2011

Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure

Zhenhua Shao, Fudong Li, Shirley M.-H. Sy, Wei Xing Yan, Zhiyong Zhang, Deshun Gong, Bin Wen, Michael S.Y. Huen, Qingguo Gong, Jihui Wu, Yunyu Shi

Journal of Structural Biology

DOI

2010

Solution structure of the second PDZ domain of Zonula Occludens 1

Peng Ji, Guang Yang, Jiahai Zhang, Jiawen Wu, Jiawen Wu, Zhengjun Chen, Qingguo Gong, Jihui Wu, Jihui Wu, Yunyu Shi

Proteins Structure Function and Bioinformatics

DOI

1999

乙肝病毒表面抗原Pre-S1的N端片段溶液构象研究

龚庆国，吴季辉，刘琴，施蕴渝，崔大敷，徐来根，张友尚

《中国科学:生命科学》

1998

Solution structure of N-terminal segment of hepatitis B virus surface antigen Pre-S1

Qingguo Gong, Jihui Wu, Qin Liu, Yunyu Shi, Dafu Cui, Laigen Xu, You‐Shang Zhang

Science in China Series C Life Sciences

DOI

精选作品

期刊论文

Structure-driven RNA remodeling underlies broad substrate recognition by NSUN2.

Structural insights into the assembly and function of Retron Ec78 PtuAB

Structural insights into the recognition and catalysis of tRNA by human NSUN2

Structural insights into dynamics of the BMV TLS aminoacylation

Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis

Elucidating the Architectural dynamics of MuB filaments in bacteriophage Mu DNA transposition

Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1.

Structural basis for Gemin5 decamer-mediated mRNA binding

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination

Crystal structure of Arabidopsis terminal uridylyl transferase URT1

Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function

Crystal Structure of Urate Oxidase from Bacillus Subtilis 168

Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering

二聚体RNA解旋酶CsdA的结构生物学研究及其C端区域的重要功能

Structural insights reveal the specific recognition of roX RNA by the dsRNA-binding domains of the RNA helicase MLE and its indispensable role in dosage compensation inDrosophila

Structural insights into a unique preference for 3′ terminal guanine of mirtron inDrosophilaTUTase tailor

Structural and functional characterization of hMEX‐3C Ring finger domain as an E3 ubiquitin ligase

Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy

Unveiling the structural features that determine the dual methyltransferase activities of Streptococcus pneumoniae RlmCD

Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII

Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions

The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3–recognition element (MRE) motif with high affinity

The important conformational plasticity of DsrA sRNA for adapting multiple target regulation

Proton-detected solid-state NMR detects the inter-nucleotide correlations and architecture of dimeric RNA in microcrystals

Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies

Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation

Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD

Determining structural ensembles of flexible multi-domain proteins using small-angle X-ray scattering and molecular dynamics simulations

Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq

Characterization of Protein Flexibility Using Small-Angle X-Ray Scattering and Amplified Collective Motion Simulations

Structural Determinants for the Strict Monomethylation Activity by Trypanosoma brucei Protein Arginine Methyltransferase 7

Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding

Crystal structure of triple‐BRCT‐domain of ECT2 and insights into the binding characteristics to CYK‐4

Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin

Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei

大肠杆菌RNA分子伴侣Hfq与DsrA和rpoS作用机制的研究进展

Hfq-bridged ternary complex is important for translation activation of rpoS by DsrA

Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate

Solution Structure of the Second RRM Domain of RBM5 and Its Unusual Binding Characters for Different RNA Targets

Identification and structural basis for a novel interaction between Vav2 and Arap3

Solution Structure of Tandem SH2 Domains from Spt6 Protein and Their Binding to the Phosphorylated RNA Polymerase II C-terminal Domain

Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure

Solution structure of the second PDZ domain of Zonula Occludens 1

乙肝病毒表面抗原Pre-S1的N端片段溶液构象研究

Solution structure of N-terminal segment of hepatitis B virus surface antigen Pre-S1

会议论文

Structural and Functional Insights into the E.coli cold shock DEAD-box RNA helicase CsdA

Understanding the mechanism of Hfq-dependent small noncoding RNA regulation of mRNA translation in bacterial stress responses

Structure and dynamics studies of non-coding RNA SLroX2

Ponsin蛋白串连SH3结构域的溶液结构及其与Vinculin相互作用的研究

核磁共振残存偶极耦合研究生物大分子结构和功能

预印本

Cooperation of Escherichia coli Hfq hexamers in DsrA binding

书籍章节

Application of NMR Spectroscopy to Determine Small RNA Structure

研究方向