王中原｜中国药科大学｜学者主页

2026

生物钟调控肝脏再生与衰老的研究进展

李瑶，向思靓，钱民先，王中原

《中国药科大学学报》

2026

The Hippo pathway effector YAP regulates macrophage phagocytosis via controlling Itgam/Itgb2 expression

Ting Wang, Xiaoyu Ma, Jing Zhang, Lei Wang, Yao Li, Xin Zhang, Tianzhi Wang, Yajun Duan, Siliang Xiang, Zhongyuan Wang, Minxian Qian

Genes & Diseases

DOI

2026

A Purified Lycii Fructus Polysaccharide Fraction Extends Healthspan in Caenorhabditis elegans with an ATFS-1/UBL-5-Associated Mitochondrial Unfolded Protein Response

Yanting Hu, Xuhan Zhang, Yihang Xu, Wenhao Fan, Zhouyuan Xue, Yutong Wang, Zhongyuan Wang, Fang Zhang, Jialiang Hu, Zheng Qiu

Antioxidants

DOI

2025

The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair

Linyuan Peng, Siliang Xiang, Tianzhi Wang, Mei Yang, Yajun Duan, Xiaoyu Ma, Su Li, Cong Yu, Xin Zhang, Hai Hu, Zuojun Liu, Jie Lena Sun, Chunmeng Sun, Chen Wang, Baohua Liu, Zhongyuan Wang, Minxian Qian

Nature Metabolism

DOI

2024

Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors

Kai Wang, Xin Zhang, Yufei Fan, Liang Fu Zhou, Yajun Duan, Li Su, Zhongkan Sun, Chunqian Zhang, Haoyu Yang, Wenxiu Yuan, Linyuan Peng, Xiaoyu Ma, Siliang Xiang, Tianzhi Wang, Mei Yang, Zhenyuan Zhang, Jiaxuan Wang, Zhongyuan Wang, Minxian Qian

Redox Biology

DOI

2024

CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

Xin Zhang, Yajun Duan, Su Li, Zhenyuan Zhang, Linyuan Peng, Xiaoyu Ma, Tianzhi Wang, Siliang Xiang, Guo Chen, Danyang Zhou, Desheng Lu, Minxian Qian, Zhongyuan Wang

Cell Reports

DOI

2024

Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang, Li Su, Kai Wang, Mei Yang, Xiaoyu Ma, Danlan Zhang, Siliang Xiang, Yajun Duan, Tianzhi Wang, Chunmeng Sun, Chen Wang, Desheng Lu, Minxian Qian, Zhongyuan Wang

Cell Reports

DOI

2024

Targeting cellular senescence: a promising anticancer strategy

Lei Wang, Yajun Duan, Xiaoyu Ma, Lida Peng, Minxian Qian, Zhongyuan Wang

Ageing and Cancer Research & Treatment

DOI

2018

哇巴因抑制Wnt/β-catenin信号通路和对肿瘤细胞的细胞毒作用

李诗乐，孙琦，李军君，王中原，苏子杰，宋佳兴，李莹，吕德生

《中国科学:生命科学》

2014

MVA和Hippo通路互作调节YAP-RHAMM转录来控制肿瘤转移

王中原

《清华大学》

王中原

精选作品

期刊论文

生物钟调控肝脏再生与衰老的研究进展

The Hippo pathway effector YAP regulates macrophage phagocytosis via controlling Itgam/Itgb2 expression

A Purified Lycii Fructus Polysaccharide Fraction Extends Healthspan in Caenorhabditis elegans with an ATFS-1/UBL-5-Associated Mitochondrial Unfolded Protein Response

The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair

Reactivation of MAPK-SOX2 pathway confers ferroptosis sensitivity in KRASG12C inhibitor resistant tumors

CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism

Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

Targeting cellular senescence: a promising anticancer strategy

哇巴因抑制Wnt/β-catenin信号通路和对肿瘤细胞的细胞毒作用

MVA和Hippo通路互作调节YAP-RHAMM转录来控制肿瘤转移

研究方向