程晓明｜武汉大学｜学者主页

2026

Establishment of a Tandem Dimeric Replication System for Torque Teno Virus In Vitro

Zulihuma Amat, Yibo Jia, Feifei Yin, Yuchen Xia, Xiaoming Cheng

Virologica Sinica

2026

RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs

M Wang, Q Chen, Yingcheng Zheng, Jiatong Yin, Guoguo Zhu, Kaitao Zhao, Z. S. Xu, Rong Hua, Meng Zhou, Lu Zhang, Gaihong Zhao, Shipeng Yang, Zulihuma Amat, Yuchen Xia, Xiaoming Cheng

Journal of Virology

DOI

2025

A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection

Xiaoming Cheng, Yuchen Xia, Chen Li, Min Zhang, Tadashi Inuzuka, Sirisha Chakka, Quan Chen, Yan Teng, Jianwei Mao, Xiaoyun Li, Wei Dong, Karim Mouzannar, Ken Chih-Chien Cheng, T. Jake Liang

Journal of Hepatology

DOI

2025

Targeting HBV cccDNA through chromatin destabilization: A new frontier in antiviral therapy

Xiaoming Cheng, Yuchen Xia

Infectious Diseases & Immunity

DOI

2025

Innate immune recognition in hepatitis B virus infection

Aixin Li, Yi Zhengjun, Chunqiang Ma, Bangyao Sun, Li Yun Zhao, Xiaoming Cheng, Lixia Hui, Yuchen Xia

Virulence

DOI

2025

Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription

Chen Li, Meng Zhou, Kaitao Zhao, Wenbo Liu, Cheng‐Liang Zhu, Xiaoming Cheng, Yuchen Xia

Virologica Sinica

DOI

2025

Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome

Kaitao Zhao, Jingjing Wang, Zichen Wang, Mengfei Wang, Chen Li, Zaichao Xu, Qiong Zhan, Fangteng Guo, Xiaoming Cheng, Yuchen Xia

PLoS Pathogens

DOI

2024

SARS-CoV-2 nsp13 suppresses hepatitis B virus replication by targeting cccDNA transcription

Aixin Li, Kaitao Zhao, Yurong Duan, Bei Zhang, Yingcheng Zheng, Cheng‐Liang Zhu, Qiongrong Chen, Wen-Bo Liu, Lixia Hui, Yuchen Xia, Xiaoming Cheng

Journal of Virology

DOI

2024

Stratifin-mediated activation of AKT signaling and therapeutic targetability in hepatocellular carcinoma progression

Rong Hua, Kaitao Zhao, Zaichao Xu, Yingcheng Zheng, Chuanjian Wu, Lu Zhang, Yan Teng, Jingjing Wang, Mengfei Wang, Jiayu Hu, Lang Chen, Detian Yuan, Wei Dong, Xiaoming Cheng, Yuchen Xia

Cell Insight

DOI

2024

Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Yingcheng Zheng, Mengfei Wang, Jiatong Yin, Yurong Duan, Chuanjian Wu, Zaichao Xu, Yanan Bu, Jingjing Wang, Quan Chen, Guoguo Zhu, Kaitao Zhao, Lu Zhang, Rong Hua, Yanping Xu, Xiyu Hu, Xiaoming Cheng, Yuchen Xia

PLoS Pathogens

DOI

2023

Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse model

Yanan Bu, Kaitao Zhao, Zaichao Xu, Yingcheng Zheng, Rong Hua, Chuanjian Wu, Chengliang Zhu, Yuchen Xia, Xiaoming Cheng

Virologica Sinica

DOI

2023

Nucleolin binds to and regulates transcription of hepatitis B virus covalently closed circular DNA minichromosome

Yuchen Xia, Xiaoming Cheng, Tobias Nilsson, Min Zhang, Gaihong Zhao, Tadashi Inuzuka, Yan Teng, Yao Li, David Eric Anderson, Meghan M. Holdorf, T. Jake Liang

Proceedings of the National Academy of Sciences

DOI

2023

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

Jingjing Wang, Haiyan Huang, Kaitao Zhao, Yan Teng, Li Zhao, Zaichao Xu, Yingcheng Zheng, Lu Zhang, Conghui Li, Yurong Duan, Kaiwei Liang, Xiang Zhou, Xiaoming Cheng, Yuchen Xia

Journal of Biological Chemistry

DOI

2023

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Aixin Li, Bei Zhang, Kaitao Zhao, Zhinang Yin, Yan Teng, Lu Zhang, Zaichao Xu, Kaiwei Liang, Xiaoming Cheng, Yuchen Xia

Journal of Virology

DOI

2023

Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies

Yingcheng Zheng, Mengfei Wang, Sitong Li, Yanan Bu, Zaichao Xu, Guoguo Zhu, Chuanjian Wu, Kaitao Zhao, Aixin Li, Quan Chen, Jingjing Wang, Rong Hua, Yan Teng, Li Zhao, Xiaoming Cheng, Yuchen Xia

PLoS Pathogens

DOI

2023

Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models

Junzhu Yi, Xinlin Lei, Fangteng Guo, Qiubing Chen, Xueyong Chen, Kaitao Zhao, Chengliang Zhu, Xiaoming Cheng, Jiangwei Lin, Hao Yin, Yuchen Xia

Antiviral Research

DOI

2022

Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment

Mingyuan Zhang, Haikun Zhang, Xiaoming Cheng, Xiaomei Wang, Hongqin Xu, Xiuzhu Gao, Ruihong Wu, Dake Zhang, Yuchen Xia, Junqi Niu

Antiviral Research

DOI

2022

Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation

Youquan Zhong, Chuanjian Wu, Zaichao Xu, Yan Teng, Li Zhao, Kaitao Zhao, Jingjing Wang, Wen Wang, Qiong Zhan, Chengliang Zhu, Xinwen Chen, Kaiwei Liang, Xiaoming Cheng, Yuchen Xia

Journal of Virology

DOI

2022

Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells

Kaitao Zhao, Fangteng Guo, Jingjing Wang, Youquan Zhong, Junzhu Yi, Yan Teng, Zaichao Xu, Li Zhao, Aixin Li, Zichen Wang, Xinwen Chen, Xiaoming Cheng, Yuchen Xia

Hepatology

DOI

2022

HIRA in Hepatitis B Virus Minichromosome Regulation: Another Piece of the Puzzle

Xiaoming Cheng, Yuchen Xia

Cellular and Molecular Gastroenterology and Hepatology

DOI

2021

A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA

Zaichao Xu, Li Zhao, Youquan Zhong, Chengliang Zhu, Kaitao Zhao, Yan Teng, Xiaoming Cheng, Qiang Chen, Yuchen Xia

Cellular and Molecular Gastroenterology and Hepatology

DOI

2018

Mechanisms of G0/G1 phase arrest induced by longevity-assurance homologue 2 in Hepa1-6 hepatoma cells

Xiao-Li Yang, Yu-Qiang Yu, Xu-Hong Ouyang, Jia-Lin Xiang, Xiaoming Cheng, Yan Yang

DOI

2010

鼠Ⅲ型肝炎病毒H-2KK限制性CTL表位的初步鉴定

龙海霞，程晓明，王远强，林勇，倪兵，朱波，吴玉章，林治华

《免疫学杂志》

2009

应用双砷荧光标记法观察乙肝病毒核心蛋白细胞内转运的实验研究

程晓明

《华中科技大学》

程晓明

精选作品

期刊论文

Establishment of a Tandem Dimeric Replication System for Torque Teno Virus In Vitro

RANBP3 and RAN orchestrate CRM1-mediated nuclear export of hepatitis B virus RNAs

A genome-wide siRNA screen identifies previously unknown proviral and antiviral host factors in HBV infection

Targeting HBV cccDNA through chromatin destabilization: A new frontier in antiviral therapy

Innate immune recognition in hepatitis B virus infection

Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription

Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome

SARS-CoV-2 nsp13 suppresses hepatitis B virus replication by targeting cccDNA transcription

Stratifin-mediated activation of AKT signaling and therapeutic targetability in hepatocellular carcinoma progression

Hepatitis B virus RNAs co-opt ELAVL1 for stabilization and CRM1-dependent nuclear export

Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse model

Nucleolin binds to and regulates transcription of hepatitis B virus covalently closed circular DNA minichromosome

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies

Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models

Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment

Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional Regulation

Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells

HIRA in Hepatitis B Virus Minichromosome Regulation: Another Piece of the Puzzle

A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNA

Mechanisms of G0/G1 phase arrest induced by longevity-assurance homologue 2 in Hepa1-6 hepatoma cells

鼠Ⅲ型肝炎病毒H-2KK限制性CTL表位的初步鉴定

应用双砷荧光标记法观察乙肝病毒核心蛋白细胞内转运的实验研究

研究方向