吴筱星｜中国药科大学｜学者主页

2026

Discovery of Biaryl amide-containing transmembrane serine protease 2 (TMPRSS2) inhibitors for the treatment of prostate Cancer

Zijie Jin, Haoxuan Yao, Jianghui Ye, Mingchen Tang, Jiaqi Cheng, Qian Chu, Zhiyong Jiang, Xiaoxing Wu

Bioorganic Chemistry

DOI

2026

A Dual-Channel NIR Fluorescent Probe for Self-Calibrated Ratiometric Imaging and In Vivo Discrimination of Malignant Tumors via Alkaline Phosphatase Activity

Xiaoping Chen, Z.H. Liu, Wenwen Lei, Min Su, Tingting Zhang, Xiaoxing Wu, Wenying Zhong, Keming Xu

Analytical Chemistry

DOI

2025

Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases

Wenhua Jiang, Qiangqiang Hou, Dexiang Hua, Yi Zeng, Chenyang Huang, Guangmei Luo, Kangming Li, Zijie Jin, Xiaoyu Chen, Wenqiang Li, Wei Li, Qian Chu, Zhiyong Jiang, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2025

Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes

Shicheng Pei, Zhaohan Liu, Qishu Jiao, Qiling Jin, Xuan Luo, Yuanyuan Liu, Shuyao Zhou, Shuqin Pang, Xiaoxing Wu, Keming Xu, Wenying Zhong

Journal of Medicinal Chemistry

DOI

2025

Front Cover: Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors (ChemMedChem 21/2025)

Yao‐Jia Li, Jiahui Zhou, Xiaoxing Wu, Wei Li, Zhe Wang, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

ChemMedChem

DOI

2025

Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors

Yao‐Jia Li, Jiahui Zhou, Xiaoxing Wu, Wei Li, Zhe Wang, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

ChemMedChem

DOI

2025

Robust Chemical Cross-linking of Proteins and Protein Complexes via SuFEx Click Chemistry

Xiaoya Li, Kai Li, Xuechun Yuan, Siyuan Hu, Zifan Wang, Ruimin Zhang, Xiaoxing Wu, Qian Chu

Analytical Chemistry

DOI

2025

1,2- trans and regioselective glycosylation of multihydroxy sugars via a simple yet synergistic combination of BF 3 ·Et 2 O in THF

Zhimei Wang, Longwei Gao, Yingjie Wang, Fuzhu Yang, Jinpeng Sang, Shuheng Pan, Xin Huang, Pan Zhang, Weijia Xie, Xiaoxing Wu, Biao Yu, Peng Hui Xu, Xiaheng Zhang, Zhaolun Zhang, Wei Li

Green Chemistry

DOI

2025

Ultraviolet/peracetic acid for degradation of antiviral drugs and control of disinfection risk.

Zi-Jun Dong, Xiaoxing Wu, Yuyang Ning, Feng Wang, Jingyun Fang, Shichang Sun, Juan Luo

Journal of Environmental Management

DOI

2024

Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Wenhua Jiang, Qiangqiang Hou, Hongrui Xu, Kexin Yang, Xiaohui Wang, Kuojun Zhang, Yi Zeng, Wenqiang Li, Bingrui Wang, Guangmei Luo, Xiao‐Fan Zhao, Hui Shen, Yong Xu, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2024

Fast and Selective Cysteine Conjugation Using para-Quinone Methides

Ruimin Zhang, Bo Li, Liuli Dong, Zhaoliang Hu, Xue Li, Xueyu Yao, Jia Ming Zheng, Aijun Lin, Shang Gao, Taijun Hang, Xiaoxing Wu, Qian Chu

Organic Letters

DOI

2024

Design, synthesis, and evaluation of dual son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancers

Yi Zeng, Chenyang Huang, Qiangqiang Hou, Wenhua Jiang, Jiaqi Cheng, Xiaoxing Wu

Bioorganic Chemistry

DOI

2023

Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers

Qiangqiang Hou, Wenhua Jiang, Wenqiang Li, Chenyang Huang, Kexin Yang, Xiaoyu Chen, Mengchen Huang, Chengxia Shu, Guangmei Luo, Haopeng Sun, Qian Chu, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2023

Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling

Guangmei Luo, Bingrui Wang, Qiangqiang Hou, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2023

Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities

Lu Lu, Jingyi Chen, Wenxiang Tao, Zhimei Wang, Dan Liu, Jiahui Zhou, Xiaoxing Wu, Haopeng Sun, Wei Li, Genzoh Tanabe, Osamu Muraoka, Bo Zhao, Liang Wu, Weijia Xie

Journal of Medicinal Chemistry

DOI

2023

A Dual‐Responsive Morphologically‐Adaptable Nanoplatform for Targeted Delivery of Activatable Photosensitizers in Precision Photodynamic Therapy

Qishu Jiao, Yaxin Zheng, Qinqing Xie, Xuan Luo, Shuyao Zhou, Shicheng Pei, Tingting Zhang, Xiaoxing Wu, Keming Xu, Wenying Zhong

Small

DOI

2023

Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells

Qishu Jiao, Yaxin Zheng, Shicheng Pei, Xuan Luo, Xiaoxing Wu, Keming Xu, Wenying Zhong

Analytical Chemistry

DOI

2022

High-Throughput Screening of Stapled Helical Peptides in Drug Discovery

Yiwei Zhang, Jiabei Guo, Jiongjia Cheng, Zhenghua Zhang, Fenghua Kang, Xiaoxing Wu, Qian Chu

Journal of Medicinal Chemistry

DOI

2022

Enzymatic Synthesis of Peptide Nanofibers for Self-Delivery of Indomethacin and Tyroservatide in Cancer Therapy

Chunlu Wang, Yao‐Yao Zheng, Yaxin Zheng, Can Wu, Xiu‐Jie Wang, Menghua Huang, Xiaoxing Wu, Wenying Zhong, Keming Xu

ACS Biomaterials Science & Engineering

DOI

2022

Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer

Xiaoyu Chen, Chengxia Shu, Wenqiang Li, Qiangqiang Hou, Guangmei Luo, Kexin Yang, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2022

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases

Dexiang Hua, Xiaoxing Wu

European Journal of Medicinal Chemistry

DOI

2021

Design, synthesis, and evaluation of novel pyridone derivatives as potent BRD4 inhibitors for the potential treatment of prostate cancer

Wenhua Jiang, Xiaohui Wang, Chengxia Shu, Qiangqiang Hou, Kexin Yang, Xiaoxing Wu

Bioorganic Chemistry

DOI

2021

Radical-mediated vicinal addition of alkoxysulfonyl/fluorosulfonyl and trifluoromethyl groups to aryl alkyl alkynes

Xinrui Dong, Wenhua Jiang, Dexiang Hua, Xiaohui Wang, Liang Xu, Xiaoxing Wu

Chemical Science

DOI

2020

Cyclin-dependent Kinase 7 Inhibitors in Cancer Therapy

Minmin Wang, Tianyu Wang, Xiangyu Zhang, Xiaoxing Wu, Sheng Jiang

Future Medicinal Chemistry

DOI

2020

A new ligand for copper-catalyzed amination of aryl halides to primary(hetero)aryl amines

Shang Jiang, Xinrui Dong, Yatao Qiu, Dong Chen, Xiaoxing Wu, Sheng Jiang

Tetrahedron Letters

DOI

2019

Targeting tropomyosin receptor kinase for cancer therapy

Qi Miao, Kun Ma, Dong Chen, Xiaoxing Wu, Sheng Jiang

European Journal of Medicinal Chemistry

DOI

2019

Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer

Kuojun Zhang, Yong Ni, Jiaxuan Chen, Zhengchao Tu, Xiaoxing Wu, Dong Chen, Hequan Yao, Sheng Jiang

Bioorganic & Medicinal Chemistry Letters

DOI

2018

Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway

Tianyu Wang, Xiaoxing Wu, Changying Guo, Kuojun Zhang, Jinyi Xu, Zheng Li, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2018

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

Kuojun Zhang, Chen Dong, Kun Ma, Xiaoxing Wu, Haiping Hao, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2018

Highly selective reduction of nitrobenzenes to azoxybenzenes with a copper catalyst

Zhichao Chen, Yatao Qiu, Xiaoxing Wu, Yong Ni, Li Ru Shen, Jun Wu, Sheng Jiang

Tetrahedron Letters

DOI

吴筱星

精选作品

期刊论文

Discovery of Biaryl amide-containing transmembrane serine protease 2 (TMPRSS2) inhibitors for the treatment of prostate Cancer

A Dual-Channel NIR Fluorescent Probe for Self-Calibrated Ratiometric Imaging and In Vivo Discrimination of Malignant Tumors via Alkaline Phosphatase Activity

Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases

Self-Reporting Ratiometric AIEgen-Peptide Nanoprobes for Activatable Chemotherapy and Noninvasive Imaging of Therapeutic Outcomes

Front Cover: Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors (ChemMedChem 21/2025)

Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors

Robust Chemical Cross-linking of Proteins and Protein Complexes via SuFEx Click Chemistry

1,2- trans and regioselective glycosylation of multihydroxy sugars via a simple yet synergistic combination of BF 3 ·Et 2 O in THF

Ultraviolet/peracetic acid for degradation of antiviral drugs and control of disinfection risk.

Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Fast and Selective Cysteine Conjugation Using para-Quinone Methides

Design, synthesis, and evaluation of dual son of sevenless 1 (SOS1) and epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancers

Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers

Development of Son of Sevenless Homologue 1 (SOS1) Modulators To Treat Cancers by Regulating RAS Signaling

Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities

A Dual‐Responsive Morphologically‐Adaptable Nanoplatform for Targeted Delivery of Activatable Photosensitizers in Precision Photodynamic Therapy

Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells

High-Throughput Screening of Stapled Helical Peptides in Drug Discovery

Enzymatic Synthesis of Peptide Nanofibers for Self-Delivery of Indomethacin and Tyroservatide in Cancer Therapy

Discovery of a Novel Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) and Cyclin-Dependent Kinase 4 (CDK4) Dual Inhibitor for the Treatment of Triple-Negative Breast Cancer

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases

Design, synthesis, and evaluation of novel pyridone derivatives as potent BRD4 inhibitors for the potential treatment of prostate cancer

Radical-mediated vicinal addition of alkoxysulfonyl/fluorosulfonyl and trifluoromethyl groups to aryl alkyl alkynes

Cyclin-dependent Kinase 7 Inhibitors in Cancer Therapy

A new ligand for copper-catalyzed amination of aryl halides to primary(hetero)aryl amines

Targeting tropomyosin receptor kinase for cancer therapy

Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer

Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) as a Therapeutic and Diagnostic Target in Cancer

Highly selective reduction of nitrobenzenes to azoxybenzenes with a copper catalyst