袁正宏｜复旦大学｜学者主页

2026

RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNα via T and B cell crosstalk remodeling

Wenjing Zai, Kongying Hu, Mengying He, Ziyang Song, Pan Gao, Chen Luo, Minxiang Xie, Asha Ashuo, Min Yang, Jieliang Chen, Zhenghong Yuan

Clinical and Molecular Hepatology

DOI

2024

医学病原与免疫基础

袁正宏

2024

基于AAV的乙肝病毒复制模型在不同遗传背景小鼠中的免疫学反应比较

王晓萌，邬敏，袁正宏，张小楠

《微生物与感染》

2024

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

mBio

DOI

2024

Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

Chao Huang, Yang Jin, Panpan Fu, Kongying Hu, Mengxue Wang, Wenjing Zai, Ting Hua, Xinluo Song, Jianyu Ye, Yiqing Zhang, Gan Luo, Haiyu Wang, Jiangxia Liu, Jieliang Chen, Xu‐Wen Li, Zhenghong Yuan

Acta Pharmaceutica Sinica B

DOI

2024

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Wenjing Zai, Min Jae Yang, Kuan Jiang, Juan Guan, Huijing Wang, Kongying Hu, Chao Ran Huang, Jieliang Chen, Wei En Fu, Changyou Zhan, Zhenghong Yuan

Signal Transduction and Targeted Therapy

DOI

2024

Anti‐HBV Activities of Cembranoids from the South China Sea Soft Coral Sinularia pedunculata and Their Structure Activity Relationship

Chao Bing Huang, Yang Jin, Ruo‐Nan Sun, Kongying Hu, Li‐Gong Yao, Yue‐Wei Guo, Zhenghong Yuan, Xu‐Wen Li

Chemistry & Biodiversity

DOI

2023

基于微滴数字PCR技术建立单细胞水平研究HBV的方法

马华杰，邬敏，张占卿，袁正宏，易志刚，张小楠

《微生物与感染》

2023

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen

Emerging Microbes & Infections

DOI

2023

Inhibition of HBV replication by EVA1A via enhancing cellular degradation of HBV components and its potential therapeutic application

Jie Yu, Zhongliang Shen, Shiqi Chen, Hongyan Liu, Zunguo Du, Richeng Mao, Jinyu Wang, Yongmei Zhang, Haoxiang Zhu, Sisi Yang, Jing Li, Jingwen Wu, Minhui Dong, Mengqi Zhu, Yuxian Huang, Jianhua Li, Zhenghong Yuan, Youhua Xie, Mengji Lu, Jiming Zhang

Antiviral Research

DOI

2022

慢性乙型肝炎患者外周血循环免疫复合物的临床意义探索

唐怡洁，邬敏，陆伟，冯艳玲，袁正宏，张小楠，张占卿

《微生物与感染》

2022

英国等地不明原因儿童肝炎的暴发情况及病因

谢幼华，陈捷亮，王勇翔，袁正宏

《微生物与感染》

2022

Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry

Xiao Ma, Zhenghong Yuan, Zhigang Yi

Emerging Microbes & Infections

DOI

2021

一场终结丙肝病毒危害人类的接力跑

宰文静，张扬，袁正宏

《科学》

2021

原卟啉Ⅸ和维替泊芬在细胞水平和小鼠体内有效抑制新型冠状病毒的感染（英文）

谷陈建，吴旸，郭慧敏，朱园飞，徐巍，王玉燕，周瑜，孙志平，蔡霞，李玉瑭，刘晶，黄忠，袁正宏，张荣，邓强，瞿涤，谢幼华

Science Bulletin

2021

丙型肝炎病毒发现及对控制病毒病的启示

袁正宏

《中国科学基金》

DOI

2021

HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage

Yang Wang, Yumeng Li, Wenjing Zai, Kongying Hu, Yuanfei Zhu, Qiang Deng, Min Wu, Yaming Li, Jieliang Chen, Zhenghong Yuan

Hepatology

DOI

2021

NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling

Jun Shu, Xiao Ma, Zhang Yang, Jingyi Zou, Zhenghong Yuan, Zhigang Yi

Emerging Microbes & Infections

DOI

2020

HBV cccDNA转录代谢调控机制及沉默清除策略

宰文静，陈捷亮，袁正宏

《临床肝胆病杂志》

2020

新型冠状病毒上海株(nCoV-SH01)的分离和鉴定

张荣，易志刚，王玉燕，滕峥，徐巍，宋武慧，蔡霞，孙志平，谷陈建，周艳秋，陈洪友，叶荣，韩文东，朱云凯，冯飞，房方皓，李崇山，张曦，瞿涤，付晨，谢幼华，袁正宏

《微生物与感染》

2020

实现慢性乙型肝炎治愈的战略计划及路径研究（美国国立卫生研究院2019年11月）

袁正宏课题组，岳蕾，唐怡洁，丁家惠，徐通，李畅，徐明珠，叶建宇，李雨檬，胡孔颖，王洋，宰文静，刘江霞，张小楠，陈捷亮，袁正宏

《肝脏》

DOI

2020

[Clinical cure strategies for hepatitis B: direct-acting antiviral drugs].

AiIong Huang, Zhenghong Yuan, Yuemin Nan, Daokun Yang, Ju‐Tao Guo, Wenhui Li

PubMed

DOI

2019

干扰素和核苷(酸)类似物治疗对HBV cccDNA的影响与慢性乙型肝炎的功能性治愈

陈捷亮，袁正宏

《临床肝胆病杂志》

2019

原位杂交技术在检测HBV核酸和cccDNA中的应用

徐通，张小楠，袁正宏

《临床肝胆病杂志》

2019

The Detection and Characterization of Herpes Simplex Virus Type 1 in Confirmed Measles Cases

Chongshan Li, Yunyi Li, Yuying Yang, Jing Wang, Caixia Zhu, Suwen Tang, Cong Pang, Wei Tang, Qiliang Cai, Zhi Li, Jiayu Hu, Xiaoxian Cui, Xi Zhang, Lin Xu, Yan Zhang, Zhengan Yuan, Yunwen Hu, Zhenghong Yuan

Scientific Reports

DOI

2017

实验准备及技术人员在提高医学微生物学教学质量中的作用

李雪萍，潘婷婷，钱利生，袁正宏，瞿涤

《微生物与感染》

2017

蛋白质精氨酸甲基转移酶5表观调控cccDNA抑制HBV复制

袁正宏

《临床肝胆病杂志》

2017

丙型肝炎病毒感染过程中其NS3/4A蛋白酶切割线粒体抗病毒信号蛋白的动态过程

许军，杜晓婷，张扬，袁正宏，易志刚

《微生物与感染》

2017

外泌体与病毒感染及HBV相关肝病的关系

贾小芳，褚巧芳，袁正宏

《临床肝胆病杂志》

2017

乙型肝炎病毒与Ⅰ型干扰素系统相互作用新机制及治疗新策略的研究

陈捷亮，李建华，张小楠，邬敏，施碧胜，方钟，袁正宏

《复旦学报(医学版)》

2017

Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP

Zhigang Yi, Zhenghong Yuan

Journal of General Virology

DOI

2017

Predictive model for inflammation grades of chronic hepatitis B: Large‐scale analysis of clinical parameters and gene expressions

Weichen Zhou, Yanyun Ma, Jun Zhang, Jingyi Hu, Menghan Zhang, Yi Wang, Yi Li, Lijun Wu, Yida Pan, Yitong Zhang, Xiaonan Zhang, Xinxin Zhang, Zhanqing Zhang, Jiming Zhang, Hai Li, Lungen Lu, Jin Li, Jiucun Wang, Zhenghong Yuan, Jie Liu

Liver International

DOI

2017

Establishment of a fluorescent in situ hybridization assay for imaging hepatitis B virus nucleic acids in cell culture models

Xiaonan Zhang, Lei Yue, Zhanqing Zhang, Zhenghong Yuan

Emerging Microbes & Infections

DOI

2016

蛋白质乙酰化对HBV复制的影响

贾小芳，张小楠，吴傲，张丽军，袁正宏

《临床肝胆病杂志》

2016

医学微生物学 = Medical microbiology

袁正宏

《复旦大学出版社》

2015

细菌学综合性实验在《医学微生物学》教学中的应用效果分析

张俊琪，谢幼华，王葳，刘晶，袁正宏，瞿涤

《微生物与感染》

2015

Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy

Jieliang Chen, Min Wu, Fan Wang, Wen Zhang, Wei Wang, Xiaonan Zhang, Jiming Zhang, Yinghui Liu, Yi Liu, Yanling Feng, Ye Zheng, Yunwen Hu, Zhenghong Yuan

Scientific Reports

DOI

2015

Innate detection of hepatitis B and C virus and viral inhibition of the response

Zhigang Yi, Jieliang Chen, Maya Kozlowski, Zhenghong Yuan

Cellular Microbiology

DOI

2015

New insights into hepatitis B virus biology and implications for novel antiviral strategies

Jieliang Chen, Min Wu, Kuancheng Liu, Wen Zhang, Yaming Li, Xiaohui Zhou, Lu Bai, Zhenghong Yuan

National Science Review

DOI

2015

Co-infection with Avian (H7N9) and Pandemic (H1N1) 2009 Influenza Viruses, China

Wanju Zhang, Dongyi Zhu, Di Tian, Lei Xu, Zhaokui Zhu, Zheng Teng, Jing He, Shan Shan, Yi Liu, Wei Wang, Zhenghong Yuan, Tao Ren, Yunwen Hu

Emerging infectious diseases

DOI

2015

A novel norovirus GII.17 lineage contributed to adult gastroenteritis in Shanghai, China, during the winter of 2014–2015

Haili Chen, Fangxing Qian, Jin Xu, Martin C.W. Chan, Zhen Zhou Shen, Shubei Zai, Menglin Shan, Jinfeng Cai, Wanju Zhang, Jing He, Yi Liu, Jun Zhang, Zhenghong Yuan, Zhaoqin Zhu, Yunwen Hu

Emerging Microbes & Infections

DOI

2014

埃博拉病毒及其致病机制

瞿涤，袁正宏，闻玉梅

《微生物与感染》

2014

不同干扰素应答慢性乙型肝炎患者的基因组DNA甲基化谱差异分析

邬敏，张小楠，陈捷亮，袁正宏

《微生物与感染》

2014

肝组织内性甾体激素受体与慢性乙型肝炎病毒复制及其抗原表达的相关性

王荣芋，张小楠，张占卿，陆伟，沈芳，冯艳玲，袁正宏

《肝脏》

2014

Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans

Kuancheng Liu, Laurie Ludgate, Zhenghong Yuan, Jianming Hu

Journal of Virology

DOI

2014

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

Yinghui Liu, Jianhua Li, Jieliang Chen, Yaming Li, Weixia Wang, Xiaoting Du, Wuhui Song, Wen Zhang, Li Lin, Zhenghong Yuan

Journal of Virology

DOI

2014

PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Wei Wang, Zhigang Song, Wencai Guan, Yi Liu, Xiaonan Zhang, Lei Xu, Jianhua Li, Zhenghong Yuan, Yunwen Hu

Emerging infectious diseases

DOI

2014

Possible pandemic threat from new reassortment of influenza A(H7N9) virus in China

Zhefeng Meng, R Han, Y Hu, Zhenghong Yuan, Shibo Jiang, Xuejun Zhang, Jianqing Xu

Eurosurveillance

DOI

2014

Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies

Jieliang Chen, Zhenghong Yuan

Virologica Sinica

DOI

2013

诺如病毒新型GII.4流行株Sydney2012在上海地区的检出和鉴定

沈震，王刚，宰淑蓓，胡芸文，袁正宏，张军

《病毒学报》

2013

H7N9禽流感诊治策略新探:来自医学检验实验室的重要线索

胡芸文，袁正宏

《检验医学》

2013

外周血单个核细胞内性甾体激素受体与慢性乙型肝炎肝组织病理状态的相关性

史慧慧，张小楠，张占卿，陆伟，沈芳，冯艳玲，袁正宏

《肝脏》

2013

An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases

Jieliang Chen, Wen Zhang, Junyu Lin, Fan Wang, Min Wu, Cuncun Chen, Ye Zheng, Xiuhua Peng, Jianhua Li, Zhenghong Yuan

Molecular Therapy

DOI

2013

Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus

Chao Qiu, Yang Huang, Anli Zhang, Di Tian, Yanmin Wan, Xiaoling Zhang, Wanju Zhang, Zhiyong Zhang, Zhenghong Yuan, Yunwen Hu, Xiaoyan Zhang, Jianqing Xu

Emerging infectious diseases

DOI

2013

Novel Norovirus GII.4 Variant, Shanghai, China, 2012

Zhen Zhou Shen, Fangxing Qian, Yang Li, Yunwen Hu, Zhenghong Yuan, Jun Zhang

Emerging infectious diseases

DOI

2013

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

Xiaonan Zhang, Zhigang Song, Boyin Qin, Xiaoling Zhang, Lixiang Chen, Yunwen Hu, Zhenghong Yuan

Antiviral Research

DOI

2012

核酸类似物PNA在HepG 2.2.15细胞中对乙型肝炎病毒复制的抑制作用

刘江霞，宋武慧，熊雅婷，丁焕平，袁正宏

《中国临床药学杂志》

2012

Plasma Microrna Profile as a Predictor of Early Virological Response to Interferon Treatment in Chronic Hepatitis B Patients

Xiaonan Zhang, Cuncun Chen, Min Wu, Liang Chen, Jiming Zhang, Xinxin Zhang, Zhanqin Zhang, Jingdi Wu, Jiefei Wang, Xiaorong Chen, Tao Huang, Lixiang Chen, Zhenghong Yuan

Antiviral Therapy

DOI

2012

Hepatitis B Virus Polymerase Impairs Interferon-α–Induced STA Activation Through Inhibition of Importin-α5 and Protein Kinase C-δ

Jieliang Chen, Min Wu, Xiaonan Zhang, Wen Zhang, Zhanqing Zhang, Lixiang Chen, Jing He, Ye Zheng, Cuncun Chen, Fan Wang, Yunwen Hu, Xiaohui Zhou, Cong Wang, Yang Y. Xu, Mengji Lu, Zhenghong Yuan

Hepatology

DOI

2011

四环素诱导的丙型肝炎病毒非结构蛋白5B稳定细胞株的构建和检测

王耀辉，丁焕平，王燏婵，袁正宏

《微生物与感染》

2011

肠道病毒71型快速培养鉴定方法的建立和应用

何静，宋志刚，张晓玲，周志统，袁正宏，胡芸文

《中国卫生检验杂志》

2011

抗肠道病毒71型药物研究进展

何静，周志统，袁正宏，胡芸文

《医学综述》

2011

Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine

Chao Qiu, Yang Huang, Qian Wang, Di Tian, Wanju Zhang, Yunwen Hu, Zhenghong Yuan, Xiaoyan Zhang, Jianqing Xu

Clinical Infectious Diseases

DOI

2011

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

Shanshan Wang, Xianfang Wu, Tingting Pan, Wuhui Song, Yaohui Wang, Fei Zhang, Zhenghong Yuan

Journal of General Virology

DOI

2011

PS2-112. Hepatitis B virus surface antigen impairs macrophage TLR4 signaling pathway via being endocytosed

Conghua Hu, Sen Wang, Shiyan Yu, Yunwen Hu, Xiaohui Zhou, Zhenghong Yuan

Cytokine

DOI

2011

Inhibition of Hepatitis B Virus Replication by cIAP2 Involves Accelerating the Ubiquitin-Proteasome-Mediated Destruction of Polymerase

Zekun Wang, Jinjing Ni, Jianhua Li, Bisheng Shi, Yang Y. Xu, Zhenghong Yuan

Journal of Virology

DOI

2011

Early Adaptive Humoral Immune Responses and Virus Clearance in Humans Recently Infected with Pandemic 2009 H1N1 Influenza Virus

Chao Qiu, Di Tian, Yanmin Wan, Wanju Zhang, Chenli Qiu, Zhaoqin Zhu, Ruiqi Ye, Zhigang Song, Mingzhe Zhou, Songhua Yuan, Bisheng Shi, Min Wu, Yi Liu, GU Shi-min, Jun Wei, Zhitong Zhou, Xiaoyan Zhang, Zhiyong Zhang, Yunwen Hu, Zhenghong Yuan, Jianqing Xu

PLoS ONE

DOI

2011

Hepatitis C Virus NS5B Protein Delays S Phase Progression in Human Hepatocyte-derived Cells by Relocalizing Cyclin-dependent Kinase 2-interacting Protein (CINP)

Yaohui Wang, Yuchan Wang, Yan Juan Xu, Wenyan Tong, Tingting Pan, Jianhua Li, Shuhui Sun, Junjie Shao, Huanping Ding, Tetsuya Toyoda, Zhenghong Yuan

Journal of Biological Chemistry

DOI

2011

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

Jianhua Li, Yinghui Liu, Zekun Wang, Kuancheng Liu, Yaohui Wang, Jiangxia Liu, Huanping Ding, Zhenghong Yuan

Journal of Virology

DOI

2010

新型甲型H1N1流感68例临床分析

黄绍萍，张占卿，卢洪洲，胡芸文，周志统，袁正宏

《实用医学杂志》

2010

α-Actinin影响丙型肝炎病毒非结构蛋白与脂筏的关联及复制

宋武慧，潘婷婷，袁正宏

《微生物与感染》

2010

上海2009甲型H1N1流行性感冒病毒全基因组分析

宋志刚，田棣，张小楠，任广旭，周志统，何静，袁正宏，胡芸文

《微生物与感染》

2010

Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR

Lü Peng, Dongyu Liang, Wenyan Tong, Jianhua Li, Zhenghong Yuan

Journal of Biological Chemistry

DOI

2010

Inhibition of Hepatitis B Virus Replication by MyD88 Involves Accelerated Degradation of Pregenomic RNA and Nuclear Retention of Pre-S/S RNAs

Jianhua Li, Shanshan Lin, Qiying Chen, Lü Peng, Jianwei Zhai, Yinghui Liu, Zhenghong Yuan

Journal of Virology

DOI

2010

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKϵ and DDX3

Shiyan Yu, Jieliang Chen, Min Wu, Hui Chen, Nobuyuki Kato, Zhenghong Yuan

Journal of General Virology

DOI

2010

Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis

Lijun Zhang, Xia Peng, Zhanqin Zhang, Yanling Feng, Xiaofang Jia, Yuxin Shi, Hua Yang, Zhiyong Zhang, Xiaonan Zhang, Liwen Liu, Lin Yin, Zhenghong Yuan

Journal of Cellular Biochemistry

DOI

2009

Viperin蛋白可通过影响非结构蛋白与脂筏的关联抑制丙型肝炎病毒复制

吴显芳，王珊珊，潘婷婷，易志刚，袁正宏

《微生物与感染》

2009

不同来源人肝细胞系β干扰素诱生及其信号通路的比较

陈辉，邬敏，于士颜，陈捷亮，袁正宏

《微生物与感染》

2009

Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HBsAg) induces potent HBsAg-specific Th1 and Th2 immune responses

Guanglin Bian, Yu‐Ming Cheng, Zekun Wang, Yunwen Hu, Xiaonan Zhang, Min Wu, Zhiao Chen, Bisheng Shi, Shuhui Sun, Yan Shen, Er jia Chen, Xin Yao, Yu‐Mei Wen, Zhenghong Yuan

Vaccine

DOI

2009

Hepatitis B virus polymerase interferes with interferon-β induction

Shiyan Yu, Jieliang Chen, Min Wu, Hui Chen, Zhenghong Yuan

Cytokine

DOI

2009

HBsAg selectively inhibited IL-12 production by interfering with TLR2-induced signaling pathway

Yunwen Hu, Zhiao Chen, Yu‐Ming Cheng, Zhenghong Yuan

Cytokine

DOI

2009

HBsAg inhibits TLR9-mediated activation and IFN-α production in plasmacytoid dendritic cells

Yongfen Xu, Yunwen Hu, Bisheng Shi, Xiaonan Zhang, Jiefei Wang, Zhanqing Zhang, Fang Shen, Qin Zhang, Shuhui Sun, Zhenghong Yuan

Molecular Immunology

DOI

2008

随机聚合酶链反应检测未知病毒方法学的建立

施碧胜，张小楠，顾士民，田棣，袁正宏，胡芸文

《微生物与感染》

2008

Measles Virus Infection in Adults Induces Production of IL-10 and Is Associated with Increased CD4+CD25+ Regulatory T Cells

Xuelian Yu, Yu‐Ming Cheng, Bisheng Shi, Fangxing Qian, Feng‐Bin Wang, Xi-nian Liu, Haiying Yang, Qingnian Xu, Tangkai Qi, Li-jun Zha, Zhenghong Yuan, Reena Ghildyal

The Journal of Immunology

DOI

2008

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients

Zhiao Chen, Yu‐Ming Cheng, Yongfen Xu, Jing Liao, Xiaonan Zhang, Yunwen Hu, Qin Zhang, Jiefei Wang, Zhanqing Zhang, Fang Shen, Zhenghong Yuan

Clinical Immunology

DOI

2008

95 Plasma derived HBsAG inhibits toll-like receptor-2 ligand induced expression of interleukin-12 and CD80 in monocytic cell line THP-1

Chen Zhiao, Cheng Yuming, Hu Yuwen, Yuan Zhenghong

Cytokine

DOI

2007

Hepatitis B virus polymerase inhibits the interferon-inducible MyD88 promoter by blocking nuclear translocation of Stat1

Min Wu, Yang Y. Xu, Shanshan Lin, Xiaonan Zhang, Xiang Li, Zhenghong Yuan

Journal of General Virology

DOI

2007

Clinical and genetic characterization of measles viruses isolated from adult patients in Shanghai in 2006

Xuelian Yu, Fangxin Qian, Yinzhong Sheng, Desheng Xie, Dan Li, Qin Huang, Yong Zhang, Zhenghong Yuan, Reena Ghildyal

Journal of Clinical Virology

DOI

2007

Inhibition of hepatitis B virus replication by MyD88 is mediated by nuclear factor-kappaB activation

Shanshan Lin, Min Wu, Xu Yang, Wei Xiong, Zhigang Yi, Xiaonan Zhang, Yuan Zhenghong

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2006

Subproteomic study of hepatitis C virus replicon reveals Ras-GTPase-activating protein binding protein 1 as potential HCV RC component

Zhigang Yi, Caiyun Fang, Tingting Pan, Jiadong Wang, Pengyuan Yang, Zhenghong Yuan

Biochemical and Biophysical Research Communications

DOI

2006

Th2 immunity to HBsAg primed by gene gun DNA vaccination can be shifted towards Th1 immunity by co-delivery or co-expression of HBV core gene

Yuan Zhenghong

Journal of Microbes and Infection

2005

Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon

Caiyun Fang, Zhigang Yi, Feng Liu, Shuiyun Lan, Jiadong Wang, Haojie Lu, Pengyuan Yang, Zhenghong Yuan

PROTEOMICS

DOI

2004

Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice

Zhijun Wang, Zhenghong Yuan, Mitsuharu Matsumoto, Ulrich R. Hengge, Yung-Fu Chang

Biochemical and Biophysical Research Communications

DOI

2004

Interferon-inducible MyD88 protein inhibits hepatitis B virus replication

Wei Xiong, Xun Wang, Xiaoying Liu, Xiang Li, Lingjie Zheng, Zhenghong Yuan

Virology

DOI

2003

T Helper 2 Immunity to Hepatitis B Surface Antigen Primed by Gene‐Gun‐Mediated DNA Vaccination can be Shifted Towards T helper 1 Immunity by Codelivery of CpG Motif‐Containing Oligodeoxynucleotides

Xian Zhou, Zheng Li, LU-MING LIU, Xiang Li, Zhenghong Yuan

Scandinavian Journal of Immunology

DOI

2003

Establishment of a cell-based assay system for hepatitis C virus serine protease and its primary applications

Hongxia Mao, Shuiyun Lan, Yunwen Hu, Xiang Li, Zhenghong Yuan

World Journal of Gastroenterology

DOI

2002

痢疾杆菌全基因组序列及基因组岛的分析

袁正宏，刘红杨帆张笑冰张继瑜杨国威董杰薛颖侯云德袁正宏闻玉梅徐建国陈洪松马大龙王宇杨剑沈岩强伯勤吴洪涛贺秉坤吕渭川金奇

《中国工程科学》，Vol. 4, No. 10

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期刊论文

RNAi-mediated HBV antigen shutdown enhances the antiviral immune effects of PEGIFNα via T and B cell crosstalk remodeling

医学病原与免疫基础

基于AAV的乙肝病毒复制模型在不同遗传背景小鼠中的免疫学反应比较

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

Anti‐HBV Activities of Cembranoids from the South China Sea Soft Coral Sinularia pedunculata and Their Structure Activity Relationship

基于微滴数字PCR技术建立单细胞水平研究HBV的方法

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Inhibition of HBV replication by EVA1A via enhancing cellular degradation of HBV components and its potential therapeutic application

慢性乙型肝炎患者外周血循环免疫复合物的临床意义探索

英国等地不明原因儿童肝炎的暴发情况及病因

Identification and characterization of key residues in Zika virus envelope protein for virus assembly and entry

一场终结丙肝病毒危害人类的接力跑

原卟啉Ⅸ和维替泊芬在细胞水平和小鼠体内有效抑制新型冠状病毒的感染（英文）

丙型肝炎病毒发现及对控制病毒病的启示

HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage

NS5-independent Ablation of STAT2 by Zika virus to antagonize interferon signalling

HBV cccDNA转录代谢调控机制及沉默清除策略

新型冠状病毒上海株(nCoV-SH01)的分离和鉴定

实现慢性乙型肝炎治愈的战略计划及路径研究（美国国立卫生研究院2019年11月）

[Clinical cure strategies for hepatitis B: direct-acting antiviral drugs].

干扰素和核苷(酸)类似物治疗对HBV cccDNA的影响与慢性乙型肝炎的功能性治愈

原位杂交技术在检测HBV核酸和cccDNA中的应用

The Detection and Characterization of Herpes Simplex Virus Type 1 in Confirmed Measles Cases

实验准备及技术人员在提高医学微生物学教学质量中的作用

蛋白质精氨酸甲基转移酶5表观调控cccDNA抑制HBV复制

丙型肝炎病毒感染过程中其NS3/4A蛋白酶切割线粒体抗病毒信号蛋白的动态过程

外泌体与病毒感染及HBV相关肝病的关系

乙型肝炎病毒与Ⅰ型干扰素系统相互作用新机制及治疗新策略的研究

Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP

Predictive model for inflammation grades of chronic hepatitis B: Large‐scale analysis of clinical parameters and gene expressions

Establishment of a fluorescent in situ hybridization assay for imaging hepatitis B virus nucleic acids in cell culture models

蛋白质乙酰化对HBV复制的影响

医学微生物学 = Medical microbiology

细菌学综合性实验在《医学微生物学》教学中的应用效果分析

Hepatitis B virus spliced variants are associated with an impaired response to interferon therapy

Innate detection of hepatitis B and C virus and viral inhibition of the response

New insights into hepatitis B virus biology and implications for novel antiviral strategies

Co-infection with Avian (H7N9) and Pandemic (H1N1) 2009 Influenza Viruses, China

A novel norovirus GII.17 lineage contributed to adult gastroenteritis in Shanghai, China, during the winter of 2014–2015

埃博拉病毒及其致病机制

不同干扰素应答慢性乙型肝炎患者的基因组DNA甲基化谱差异分析

肝组织内性甾体激素受体与慢性乙型肝炎病毒复制及其抗原表达的相关性

Regulation of Multiple Stages of Hepadnavirus Replication by the Carboxyl-Terminal Domain of Viral Core Protein in trans

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways

PCR for Detection of Oseltamivir Resistance Mutation in Influenza A(H7N9) Virus

Possible pandemic threat from new reassortment of influenza A(H7N9) virus in China

Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies

诺如病毒新型GII.4流行株Sydney2012在上海地区的检出和鉴定

H7N9禽流感诊治策略新探:来自医学检验实验室的重要线索

外周血单个核细胞内性甾体激素受体与慢性乙型肝炎肝组织病理状态的相关性

An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases

Safe Pseudovirus-based Assay for Neutralization Antibodies against Influenza A(H7N9) Virus

Novel Norovirus GII.4 Variant, Shanghai, China, 2012

Rupintrivir is a promising candidate for treating severe cases of enterovirus-71 infection: Evaluation of antiviral efficacy in a murine infection model

核酸类似物PNA在HepG 2.2.15细胞中对乙型肝炎病毒复制的抑制作用

Plasma Microrna Profile as a Predictor of Early Virological Response to Interferon Treatment in Chronic Hepatitis B Patients

Hepatitis B Virus Polymerase Impairs Interferon-α–Induced STA Activation Through Inhibition of Importin-α5 and Protein Kinase C-δ

四环素诱导的丙型肝炎病毒非结构蛋白5B稳定细胞株的构建和检测

肠道病毒71型快速培养鉴定方法的建立和应用

抗肠道病毒71型药物研究进展

Boosting Heterosubtypic Neutralization Antibodies in Recipients of 2009 Pandemic H1N1 Influenza Vaccine

Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33

PS2-112. Hepatitis B virus surface antigen impairs macrophage TLR4 signaling pathway via being endocytosed

Inhibition of Hepatitis B Virus Replication by cIAP2 Involves Accelerating the Ubiquitin-Proteasome-Mediated Destruction of Polymerase

Early Adaptive Humoral Immune Responses and Virus Clearance in Humans Recently Infected with Pandemic 2009 H1N1 Influenza Virus

Hepatitis C Virus NS5B Protein Delays S Phase Progression in Human Hepatocyte-derived Cells by Relocalizing Cyclin-dependent Kinase 2-interacting Protein (CINP)

Subversion of Cellular Autophagy Machinery by Hepatitis B Virus for Viral Envelopment

新型甲型H1N1流感68例临床分析

α-Actinin影响丙型肝炎病毒非结构蛋白与脂筏的关联及复制

上海2009甲型H1N1流行性感冒病毒全基因组分析

Hepatitis C Virus NS5A Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Contributing to Cell Survival by Disrupting the Interaction between FK506-binding Protein 38 (FKBP38) and mTOR

Inhibition of Hepatitis B Virus Replication by MyD88 Involves Accelerated Degradation of Pregenomic RNA and Nuclear Retention of Pre-S/S RNAs

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKϵ and DDX3

Subcellular proteome analysis unraveled annexin A2 related to immune liver fibrosis

Viperin蛋白可通过影响非结构蛋白与脂筏的关联抑制丙型肝炎病毒复制

不同来源人肝细胞系β干扰素诱生及其信号通路的比较