年四辉｜皖南医学院｜学者主页

2026

The Active Fraction From Polyporus umbellatus Against Hyperuricemia

Jian Luo, Xin-yu Chen, Runze Jin, Si-yao Zhang, Meng-qi Zhou, Y Chen, YU Sun, Dao-yin Yang, Xiao-wen Gong, Jian-hao Xu, Sihui Nian, Ling-yun Zhou

Die Pharmazie

DOI

2026

Exploring the mechanism of action of Qufengzhitong pills in treating rheumatoid arthritis via the PI3K/AKT, NF-κB, and MAPK pathways

Jie Li, Rongxue Li, Yue Wang, Marwan M A Rashed, Dejun Qi, Yuanjie He, Chenghui He, Yanxu Chang, Sihui Nian, Hong Duan, Henggui Hu, Kefeng Zhai

Journal of Pharmacy and Pharmacology

DOI

2025

AI赋能“天然药物化学”教学的探索与实践

王存琴，年四辉，张艳华，包淑云，宋孝君

《通化师范学院学报》

DOI

2025

《天然药物化学》实验教学的思考与探究

包淑云，张艳华，年四辉，宋孝君，陈颖，王存琴

《承德医学院学报》

DOI

2025

宣肺化痰止咳方煮散剂煎煮工艺研究

祁俊，金润泽，陈心雨，凌骢，年四辉，周凌云

《现代中药研究与实践》

2025

“物理化学”课程思政教学的探索与效果分析——以“相平衡”为例

赵志刚，金丹，喻丽珍，李贵文，年四辉

《云南化工》

2025

断血流药材品质评价初步研究

刘丽敏，刘遥，沈学彬，年四辉

《现代中药研究与实践》

DOI

2025

Recent progress in developing ATR inhibitors as anticancer agents

Shaohua Hou, Yu Sun, Lingyun Zhou, Lin Tang, Ruobing Tang, Fangfang Li, Xiaoyu He, Yanwen Cao, Guodong Wang, Sihui Nian, Peng Wei Zhu

Biochemical Pharmacology

DOI

2025

Ergothioneine Attenuates CCl 4 ‐Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis via Regulating LKB1/Nrf2 Pathway

Tiantian Zhang, Xiao Lei, Guangqiong Li, Zhiyong Zheng, Huifan Yu, Lvyi Chen, Sihui Nian, Guangwen Shu, Xukun Deng

The FASEB Journal

DOI

2025

Modulation of Stem Cell Survival and Engraftment: Implications for Stem Cell-Based Therapy

Qingwen Xu, Chaochao Zhang, Xinyu Liu, Yuyao Sun, Bowei Li, Sihui Nian, Yan Wang, Chenggong Yu

Theranostics

DOI

2025

Combination Treatment of Timosaponin BII and Pirfenidone Attenuated Pulmonary Fibrosis Through Anti-Inflammatory and Anti-Fibrotic Process in Rodent Pulmonary Fibrosis Model and Cellular Epithelial–Mesenchymal Transition Model

Xuebin Shen, Yueyue Zheng, Hui Yang, Li Liu, Li Liu, Lizhen Yu, Yuanxiang Zhang, Xiaojun Song, Yuqing He, Runze Jin, Jianhao Jiao, Zhihui Gu, Kefeng Zhai, Sihui Nian, Limin Liu, Limin Liu

Molecules

DOI

2025

Application of Metabolomics and Microbiome Analysis for Revealing the Endogenous Mechanism of Baizhu Xiaozhong San in Postpartum Rats with Spleen-qi Deficiency

Di Cao, Jie Chen, Yanhua Zhang, Hao Rui, 克彦貞廣, Le Zhang, Ruyi Wu, Sihui Nian, Xiaojun Song

Journal of Medicinal Food

DOI

2024

新《中华人民共和国药品管理法》背景下混合式课堂教学效果探究

徐诗霞，张文，叶兰，喻丽珍，年四辉

《皖南医学院学报》

2024

Advances in understanding the role of interleukins in pulmonary fibrosis (Review)

Yuqing He, Xuebin Shen, Kefeng Zhai, Sihui Nian

Experimental and Therapeutic Medicine

DOI

2024

Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4

Kefeng Zhai, Liangle Deng, Yuxuan Wu, Han Li, Jing Zhou, Ying Shi, Jianhu Jia, Wei Wang, Sihui Nian, Ghulam Jilany Khan, Hesham R. El‐Seedi, Hong Quan Duan, Lili Li, Zhao‐Jun Wei

Journal of Advanced Research

DOI

2024

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology.

Runze Jin, Zitong Zhao, Qing Zhang, Yizhou Sun, Wei Wang, Daiyin Peng, Sihui Nian, Lingyun Zhou

PubMed

DOI

2024

Poria cocos Attenuated DSS-Induced Ulcerative Colitis via NF-κB Signaling Pathway and Regulating Gut Microbiota

Xiaojun Song, Wei J. Wang, Li Liu, Zitong Zhao, Xuebin Shen, Lingyun Zhou, Yuanxiang Zhang, Daiyin Peng, Sihui Nian

Molecules

DOI

2024

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology

Runze Jin, Zitong Zhao, Qing Zhang, YU Sun, Wei Wang, Daiyin Peng, Sihui Nian, Lingyun Zhou

Die Pharmazie

DOI

2023

茯苓皮提取物对高尿酸血症小鼠的尿酸水平和肾脏的影响

赵梓童，年四辉，孙绪强，汪伟，张青，彭代银，周凌云

《海南医科大学学报》

2023

Timosaponin BII inhibits TGF ‐β mediated epithelial‐mesenchymal transition through Smad‐dependent pathway during pulmonary fibrosis

Da-Li Ding, Xuebin Shen, Lizhen Yu, Yueyue Zheng, Yao Liu, Wei Wang, Li Liu, Li Liu, Zitong Zhao, Sihui Nian, Limin Liu, Limin Liu

Phytotherapy Research

DOI

2022

《中国药典》断血流功能与主治的商榷

武培璐，熊远根，年四辉，武为宝

《安徽医药》

2022

中药学形象思维教学探讨

曹迪，徐诗霞，年四辉，郑咏秋

《中国中医药现代远程教育》

2022

黄秋葵粗多糖对脾虚便秘模型小鼠的作用及机制研究

何宝佳，魏蔚，张艳华，尹良辰，张会宁，年四辉

《中药新药与临床药理》

2022

多维教学模式在“中药鉴定学”课程教学改革中的实践

何宝佳，曹迪，张艳华，包淑云，周思了，年四辉

《通化师范学院学报》

2022

不同教学模式在药物经济学教学中的应用现状

徐诗霞，殷勤，年四辉

《中国药物经济学》

2022

The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance

Wenchong Ye, Chuangchuang Fan, Kaishou Fu, Xiaoyang Wang, Jingchao Lin, Sihui Nian, Chunhui Liu, Wen Zhou

European Journal of Medicinal Chemistry

DOI

2022

A Rapid and Efficient Strategy for Quality Control of Clinopodii herba Encompassing Optimized Ultrasound-Assisted Extraction Coupled with Sensitive Variable Wavelength Detection

Yao Liu, Xiaojun Song, Xuebin Shen, Yuangen Xiong, Li Liu, Yuexi Yang, Sihui Nian, Limin Liu

Molecules

DOI

2021

香椿子提取物对实验性小鼠胃黏膜损伤保护作用

李丽华，章圣朋，秦加旭，年四辉

《中国临床药理学与治疗学》

2021

线上线下混合式教学在“生物药剂学与药物动力学”实验教学中的设计与应用

李丽华，章圣朋，朱磊，孙淑萍，鄢海燕，年四辉

《通化师范学院学报》

DOI

2021

《中药炮制学》实验教学改革的探索

周凌云，年四辉，何宝佳，何丽霞

《牡丹江医科大学学报》

2021

Total extract of Anemarrhenae Rhizoma attenuates bleomycin-induced pulmonary fibrosis in rats

Xuebin Shen, Da-Li Ding, Lizhen Yu, Jin-Zhong Ni, Yao Liu, Wei Wang, Limin Liu, Sihui Nian

Bioorganic Chemistry

DOI

2021

Burdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic mice

Pingchuan Yuan, Taili Shao, Jun Hyun Han, Chunyan Liu, Guo-dong Wang, Shuguang He, Xu Shixia, Sihui Nian, Kaoshan Chen

Journal of Functional Foods

DOI

2021

Corrigendum to “Molecular networking uncovers steroidal saponins of Paris tengchongensis” [Fitoterapia 145 (2020) 104629]

Jie Wang, Dan Li, Wei Min NI, Xu‐Jie Qin, Hui Liu, Hui Liu, Ling-Ling Yu, Xue Qiao, Yun-Heng Ji, Li He, Sihui Nian, Hai‐Yang Liu, Hai‐Yang Liu

Fitoterapia

DOI

2021

Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo

Ding‐Qiao Xu, Hanfeng Lin, Yuping Tang, Lu Huang, Jian Xu, Sihui Nian, Yucheng Zhao

Horticulture Research

DOI

2020

以学习能力培养为导向的天然药物化学实验教学改革与实践

年四辉，包淑云，王存琴，张艳华，何宝佳

《通化师范学院学报》

DOI

2020

以应用能力培养为导向的生药学实验教学改革与探索

年四辉，包淑云，喻丽珍，张艳华，王存琴，何宝佳，曹迪

《齐齐哈尔医学院学报》

2020

Gastrodin prevents homocysteine‐induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway

Jiyu Chen, Yanli Huang, Xiaochuan Hu, Xiaohong Bian, Sihui Nian

Journal of Cellular and Molecular Medicine

DOI

2020

[Research progress on genus Clinopodium].

Yao Liu, Liu Li-Min, Xiong Yuan-Gen, Shen Xue-Bin, Huan Liu, Sihui Nian

PubMed

DOI

2020

Molecular networking uncovers steroidal saponins of Paris tengchongensis

Jie Wang, Dan Li, Wei Min NI, Xu‐Jie Qin, Hui Liu, Hui Liu, Ling-Ling Yu, Xue Qiao, Yunheng Ji, Li He, Sihui Nian, Hai‐Yang Liu, Hai‐Yang Liu

Fitoterapia

DOI

2020

Identification and Selection of Reference Genes for Quantitative Transcript Analysis in Corydalis yanhusuo

Zhenzhen Bao, Kaidi Zhang, Hanfeng Lin, Changjian Li, Xiurong Zhao, Jie Wu, Sihui Nian

Genes

DOI

2019

信息化教学背景下精品资源共享课程建设与思考

王存琴，张艳华，包淑云，年四辉，喻丽珍

《通化师范学院学报》

DOI

2019

胶质重楼石灰水炮制工艺研究

刘丽敏，陈成，崔展红，年四辉

《广州化工》

2018

芒果苷对HepG2细胞侵袭及转移的抑制作用及机制研究

喻丽珍，年四辉，李丽华，王涵

《通化师范学院学报》

2018

不同醋制工艺对元胡中延胡索乙素溶出的影响

张艳华，包淑云，年四辉，方昌樵，郭祥

《通化师范学院学报》

2018

醋炙元胡中延胡索乙素不同提取方法比较

张艳华，包淑云，年四辉，喻丽珍，刘人豪

《赤峰学院学报(自然科学版)》

DOI

2017

一种新的基于微透析技术研究靶器官药代动力学方法

费佳丽，朱岳，马张庆，年四辉，洪宗元

《皖南医学院学报》

2017

穿山龙中薯蓣皂苷酶提取工艺的优化

江慧，孙蓉，汪魏平，徐文科，陆小凤，年四辉

《中成药》

2017

皖南医学院校园植物资源调查与校园绿化建议

喻丽珍，年四辉，包淑云，张艳华，王存琴，魏远娜

《宜春学院学报》

2016

药用植物学与生药学实验教学及考核改革

张艳华，王存琴，包淑云，喻丽珍，年四辉

《宜春学院学报》

2014

纤维素酶解滁菊提取多糖工艺及滁菊多糖抗氧化性研究

熊磊，年四辉，朱玉

《皖南医学院学报》

2013

多指标淀粉酶法提取板蓝根有效成分工艺初步探讨

年四辉，刘丽敏，张艳华，夏轩轩

《中成药》

2013

超临界CO2流体萃取板蓝根中（R,S）-告依春的工艺

年四辉，柳春燕，刘丽敏，杨丽芬

《中药材》

2013

[The extraction technology of epigoitri from isatidis radix by supercritical CO2 fluid].

Sihui Nian, Chunyun Liu, Li-Min Liu, Yang Li-fen

PubMed

2012

断血流皂苷的大孔吸附树脂纯化工艺研究

刘丽敏，年四辉，刘东平，徐贵明

《中成药》

2012

大孔吸附树脂富集板蓝根中(R,S)-告依春工艺研究

年四辉，刘丽敏，喻丽珍，赵明明

《离子交换与吸附》

2012

HPLC测定板蓝根及其制剂中水杨酸、苯甲酸的含量

年四辉，李萍，刘丽敏，李丽华

《中国实验方剂学杂志》

2012

断血流及其制剂中总黄酮的含量测定研究

年四辉，刘丽敏，廖启元，陈富华

《中国民族民间医药》

2012

生药学教材内容的改革

年四辉，包淑云，张艳华，喻丽珍

《药学教育》

2011

石灰水在中药炮制方法中的研究进展

年四辉，刘丽敏，包淑云，张艳华

《中国医药导报》

2011

静态吸附杜仲叶中绿原酸较合适树脂的研究

罗剑，吴海振，年四辉

《安徽医药》

2011

纤维素酶法提取断血流皂苷的工艺研究

刘丽敏，年四辉，吴海振

《中成药》

2011

板蓝根药材及颗粒中总有机酸含量测定方法研究

刘丽敏，年四辉，包淑云，刘子荣

《现代中药研究与实践》

2011

More appropriate resins on the static adsorption of chlorogenic acid from eucommia leaf

Sihui Nian

Anhui Medical and Pharmaceutical Journal

2010

人文教育在生药学课程教学中的渗透

包淑云，年四辉，张艳华，喻丽珍

《中国高等医学教育》

2007

重楼地上部分初步开发实验研究

年四辉，刘丽敏

《云南中医中药杂志》

DOI

2006

重楼水提工艺的初步研究

年四辉，张赫名，郑渝艳

《云南中医药大学学报》

2006

水提天麻工艺的初步研究

张赫名，年四辉

《云南中医药大学学报》

2006

树脂技术用于重楼总皂苷纯化工艺的研究

年四辉，王扣，罗燕

《云南中医中药杂志》

DOI

2004

水提三七有效部位重金属及农药残留的研究

龚耀刚，王兴文，程莉，年四辉，张赫名，孙小玲

《云南中医药大学学报》

精选作品

期刊论文

The Active Fraction From Polyporus umbellatus Against Hyperuricemia

Exploring the mechanism of action of Qufengzhitong pills in treating rheumatoid arthritis via the PI3K/AKT, NF-κB, and MAPK pathways

AI赋能“天然药物化学”教学的探索与实践

《天然药物化学》实验教学的思考与探究

宣肺化痰止咳方煮散剂煎煮工艺研究

“物理化学”课程思政教学的探索与效果分析——以“相平衡”为例

断血流药材品质评价初步研究

Recent progress in developing ATR inhibitors as anticancer agents

Ergothioneine Attenuates CCl 4 ‐Induced Acute Liver Injury by Inhibiting Oxidative Stress and Apoptosis via Regulating LKB1/Nrf2 Pathway

Modulation of Stem Cell Survival and Engraftment: Implications for Stem Cell-Based Therapy

Combination Treatment of Timosaponin BII and Pirfenidone Attenuated Pulmonary Fibrosis Through Anti-Inflammatory and Anti-Fibrotic Process in Rodent Pulmonary Fibrosis Model and Cellular Epithelial–Mesenchymal Transition Model

Application of Metabolomics and Microbiome Analysis for Revealing the Endogenous Mechanism of Baizhu Xiaozhong San in Postpartum Rats with Spleen-qi Deficiency

新《中华人民共和国药品管理法》背景下混合式课堂教学效果探究

Advances in understanding the role of interleukins in pulmonary fibrosis (Review)

Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology.

Poria cocos Attenuated DSS-Induced Ulcerative Colitis via NF-κB Signaling Pathway and Regulating Gut Microbiota

An anti-inflammatory active ingredients in Poriae cutis: Screening based on network pharmacology

茯苓皮提取物对高尿酸血症小鼠的尿酸水平和肾脏的影响

Timosaponin BII inhibits TGF ‐β mediated epithelial‐mesenchymal transition through Smad‐dependent pathway during pulmonary fibrosis

《中国药典》断血流功能与主治的商榷

中药学形象思维教学探讨

黄秋葵粗多糖对脾虚便秘模型小鼠的作用及机制研究

多维教学模式在“中药鉴定学”课程教学改革中的实践

不同教学模式在药物经济学教学中的应用现状

The SAR and action mechanisms of autophagy inhibitors that eliminate drug resistance

A Rapid and Efficient Strategy for Quality Control of Clinopodii herba Encompassing Optimized Ultrasound-Assisted Extraction Coupled with Sensitive Variable Wavelength Detection

香椿子提取物对实验性小鼠胃黏膜损伤保护作用

线上线下混合式教学在“生物药剂学与药物动力学”实验教学中的设计与应用

《中药炮制学》实验教学改革的探索

Total extract of Anemarrhenae Rhizoma attenuates bleomycin-induced pulmonary fibrosis in rats

Burdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic mice

Corrigendum to “Molecular networking uncovers steroidal saponins of Paris tengchongensis” [Fitoterapia 145 (2020) 104629]

Integration of full-length transcriptomics and targeted metabolomics to identify benzylisoquinoline alkaloid biosynthetic genes in Corydalis yanhusuo

以学习能力培养为导向的天然药物化学实验教学改革与实践

以应用能力培养为导向的生药学实验教学改革与探索

Gastrodin prevents homocysteine‐induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway

[Research progress on genus Clinopodium].

Molecular networking uncovers steroidal saponins of Paris tengchongensis

Identification and Selection of Reference Genes for Quantitative Transcript Analysis in Corydalis yanhusuo

信息化教学背景下精品资源共享课程建设与思考

胶质重楼石灰水炮制工艺研究

芒果苷对HepG2细胞侵袭及转移的抑制作用及机制研究

不同醋制工艺对元胡中延胡索乙素溶出的影响

醋炙元胡中延胡索乙素不同提取方法比较

一种新的基于微透析技术研究靶器官药代动力学方法

穿山龙中薯蓣皂苷酶提取工艺的优化

皖南医学院校园植物资源调查与校园绿化建议

药用植物学与生药学实验教学及考核改革

纤维素酶解滁菊提取多糖工艺及滁菊多糖抗氧化性研究

多指标淀粉酶法提取板蓝根有效成分工艺初步探讨

超临界CO2流体萃取板蓝根中（R,S）-告依春的工艺

[The extraction technology of epigoitri from isatidis radix by supercritical CO2 fluid].

断血流皂苷的大孔吸附树脂纯化工艺研究

大孔吸附树脂富集板蓝根中(R,S)-告依春工艺研究

HPLC测定板蓝根及其制剂中水杨酸、苯甲酸的含量

断血流及其制剂中总黄酮的含量测定研究

生药学教材内容的改革

石灰水在中药炮制方法中的研究进展

静态吸附杜仲叶中绿原酸较合适树脂的研究

纤维素酶法提取断血流皂苷的工艺研究

板蓝根药材及颗粒中总有机酸含量测定方法研究

More appropriate resins on the static adsorption of chlorogenic acid from eucommia leaf

人文教育在生药学课程教学中的渗透

重楼地上部分初步开发实验研究

重楼水提工艺的初步研究

水提天麻工艺的初步研究

树脂技术用于重楼总皂苷纯化工艺的研究

水提三七有效部位重金属及农药残留的研究

预印本

A Simple and Economic Limewater-based Conversion of Spirostanol Saponins: Using Paridis Rhizoma as a case study