马健｜中南大学｜学者主页

2025

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Zheng Xiang, Jia‐Yi Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma

Advanced Science

DOI

2025

Building a Bridge Between the Mechanism of EBV Reactivation and the Treatment of EBV‐Associated Cancers

Jialin Jiang, Xinlei Zhu, Shukun Li, Qun Yan, Jian Ma

Journal of Medical Virology

DOI

2024

EB病毒的潜伏-裂解感染:调控机制与靶向策略

邓红雨，卢建红，冯琳，马健

《中国科学:生命科学》

2024

Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion

Xiaoyue Zhang, Zhengshuo Li, Peng Qiu, Can Liu, Yangge Wu, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Xiang Zheng, Qun Yan, Jia Wang, Jian Ma

Journal of Biological Chemistry

DOI

2023

Epstein–Barr virus microRNA miR-BART2-5p accelerates nasopharyngeal carcinoma metastasis by suppressing RNase Ⅲ endonuclease DICER1

Yangge Wu, Xiao-Yue Zhang, Can Liu, Zhengshuo Li, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Lingyu Wei, Jia Wang, Qun Yan, Xiang Zheng, Jian Ma

Journal of Biological Chemistry

DOI

2023

Liquid-liquid Phase Separation in Viral Function

Xiaoyue Zhang, Run Zheng, Zhengshuo Li, Jian Ma

Journal of Molecular Biology

DOI

2021

Epstein–Barr virus EBNA2 phase separation regulates cancer‐associated alternative RNA splicing patterns

Qiu Peng, Lu-Juan Wang, Jia Wang, Can Liu, Xiang Zheng, Xiao-Yue Zhang, Lingyu Wei, Zhengshuo Li, Yangge Wu, Yuqing Wen, Peng-Fei Cao, Q. Liao, Qun Yan, Jian Ma

Clinical and Translational Medicine

DOI

2021

RNA m6A methylation regulates virus–host interaction and EBNA2 expression during Epstein–Barr virus infection

Xiang Zheng, Jia Wang, Xiao-Yue Zhang, Yu-Xin Fu, Qiu Peng, Jian-Hong Lu, Lingyu Wei, Zhengshuo Li, Can Liu, Yangge Wu, Qun Yan, Jian Ma

Immunity, Inflammation and Disease

DOI

2021

EBV as a high infection risk factor promotes RASSF10 methylation and induces cell proliferation in EBV-associated gastric cancer.

Yingxue Gao, Yu-Xin Fu, Jia Wang, Xiang Zheng, Jian-Hua Zhou, Jian Ma

Biochemical and Biophysical Research Communications - BBRC

DOI

2020

EBV‐miR‐BART12 accelerates migration and invasion in EBV‐associated cancer cells by targeting tubulin polymerization‐promoting protein 1

Yingfen Wu, Dan Wang, F. Wei, Fang Xiong, Shan-Shan Zhang, Zhao-Jian Gong, Lei Shi, Xia-Yu Li, Bo Xiang, Jian Ma, H. Deng, Yi He, Q. Liao, Wenling Zhang, Xiao-Ling Li, Yong Li, Can Guo, Z. Zeng, Gui-Yuan Li, W. Xiong

The FASEB Journal

DOI

2020

Phase Separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP Controls Gene Expression

Qiu Peng, Lu-Juan Wang, Zai-Long Qin, Jia Wang, Xiang Zheng, Lingyu Wei, Xiao-Yue Zhang, Xue-Mei Zhang, Can Liu, Zhengshuo Li, Yangge Wu, Gui-Yuan Li, Qun Yan, Jian Ma

Journal of Virology

DOI

2019

Epstein–Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer

Jia Wang, Xiang Zheng, Zai-Long Qin, Lingyu Wei, Yuan-Jun Lu, Qiu Peng, Yingxue Gao, Xue-Mei Zhang, Xiao-Yue Zhang, Zhengshuo Li, Yu-Xin Fu, Peishan Liu, Can Liu, Qun Yan, W. Xiong, Gui-Yuan Li, Jian-Hong Lu, Jian Ma

Journal of Biological Chemistry

DOI

2018

Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression

Xiang Zheng, Jia Wang, Lingyu Wei, Qiu Peng, Yingxue Gao, Yu-Xin Fu, Yuan-Jun Lu, Zai-Long Qin, Xue-Mei Zhang, Jian-Hong Lu, Chun-Lin Ou, Zhengshuo Li, Xiao-Yue Zhang, Peishan Liu, W. Xiong, Gui-Yuan Li, Qun Yan, Jian Ma

Journal of Virology

DOI

2017

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway

Yuan-Jun Lu, Zai-Long Qin, Jia Wang, Xiang Zheng, Jian-Hong Lu, Xue-Mei Zhang, Lingyu Wei, Qiu Peng, Ying Zheng, Chun-Lin Ou, Q. Ye, W. Xiong, Gui-Yuan Li, Yu-Xin Fu, Qun Yan, Jian Ma

Journal of Innate Immunity

DOI

2016

Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103

Baoyu He, Weiming Li, Yingfen Wu, F. Wei, Zhao-Jian Gong, H. Bo, Yu-Min Wang, Xia-Yu Li, Bo Xiang, Can Guo, Q. Liao, Pan Chen, Xu-Yu Zu, Ming Zhou, Jian Ma, X. Li, Yong Li, Gui-Yuan Li, W. Xiong, Z. Zeng

Cell Death and Disease

DOI

2016

Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1

Ya-Li Song, X. Li, Z. Zeng, Qiao Li, Zhao-Jian Gong, Q. Liao, Xia-Yu Li, Pan Chen, Bo Xiang, Wenling Zhang, Fang Xiong, Yan-Hong Zhou, Ming Zhou, Jian Ma, Yong Li, Xiang Chen, Gui-Yuan Li, W. Xiong

OncoTarget

DOI

2015

EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC

Qi-Jia Yan, Z. Zeng, Zhao-Jian Gong, Wenling Zhang, Xia-Yu Li, Baoyu He, Ya-Li Song, Qiao Li, Yong Zeng, Q. Liao, Pan Chen, Lei Shi, Song-Qing Fan, Bo Xiang, Jian Ma, Ming Zhou, Xiao-Ling Li, Jianbo Yang, W. Xiong, Gui-Yuan Li

OncoTarget

DOI

2015

SPLUNC1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the EB virus by inhibiting the TLR9/NF-κB pathway.

Chun-Lin Ou, Zhenqiang Sun, Han-Jie Zhang, W. Xiong, Jian Ma, Ming Zhou, Jian-Hong Lu, Z. Zeng, X. Bo, Pan Chen, Gui-Yuan Li, Xia-Yu Li, Xiao-Ling Li

Oncology Report

DOI

2014

PLUNC蛋白家族在抑制鼻咽上皮“炎-癌”演进中的作用和机制

魏芳，李夏雨，李小玲，张文玲，廖前进，曾勇，龚朝建，周鸣，马健，熊炜，沈守荣，曾朝阳

《生物化学与生物物理进展》

2014

一个肝癌相关长链非编码RNA的克隆及序列分析

唐珂，魏芳，孛昊，黄宏斌，张文玲，龚朝建，李夏雨，宋亚莉，廖前进，彭淑平，向娟娟，周鸣，马健，李小玲，熊炜，李勇，曾朝阳，李桂源

《生物化学与生物物理进展》

2014

Lactoferrin suppresses the Epstein–Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9

Ying Zheng, Zai-Long Qin, Q. Ye, Pan Chen, Zhen Wang, Qun Yan, Zhao-Hui Luo, Xiao-Ping Liu, Yan-Hong Zhou, W. Xiong, Jian Ma, Gui-Yuan Li

Laboratory Investigation

DOI

2013

染色质免疫沉淀-测序:全基因组范围研究蛋白质-DNA相互作用的新技术

梁芳，徐柯，龚朝建，李俏，马健，熊炜，曾朝阳，李桂源

《生物化学与生物物理进展》

2013

天然免疫分子乳铁蛋白抑制鼻咽癌的发生发展

黄宏斌，邓敏，郑瑛，马健，张文玲，周艳宏，廖前进，熊炜，李小玲，曾朝阳，李桂源

《生物化学与生物物理进展》

2013

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Pan Chen, Xiao-Fang Guo, Hou-De Zhou, Wenling Zhang, Z. Zeng, Q. Liao, Xia-Yu Li, Bo Xiang, Jianbo Yang, Jian Ma, Ming Zhou, Shu-Ping Peng, Juan-Juan Xiang, X. Li, C. Le, W. Xiong, J. McCarthy, Gui-Yuan Li

PLoS ONE

DOI

2012

Inhibition of Epstein-Barr Virus Infection by Lactoferrin

Ying Zheng, Wenling Zhang, Q. Ye, Yan-Hong Zhou, W. Xiong, Wei He, M. Deng, Ming Zhou, Xiao-Fang Guo, Pan Chen, Song-Qing Fan, Xiao-Ping Liu, Zhen Wang, Xiaoling Li, Jian Ma, Gui-Yuan Li

Journal of Innate Immunity

DOI

2011

多基因遗传性肿瘤不同阶段转录组学调控规律及其分子机制

李夏雨，沈守荣，武明花，李小玲，熊炜，卢建红，周鸣，马健，向娟娟，曾朝阳，向波，周艳宏，肖岚，周厚德，范松青，李桂源

《中南大学学报(医学版)》

2008

Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus

Hou-De Zhou, Xiao-Ling Li, Gui-Yuan Li, Ming Zhou, Hua-ying Liu, Yi-Xin Yang, Tan Deng, Jian Ma, Shou-rong Sheng

Molecular and Cellular Biochemistry

DOI

2006

Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis.

Song-Qing Fan, Jian Ma, Jie Zhou, W. Xiong, Bing-yi Xiao, Wen-Ling Zhang, Chen Tan, Xiao-Ling Li, Shou-rong Shen, Ming Zhou, Qiu-hong Zhang, Yang-jue Ou, Hou Zhuo, Song-Qing Fan, Yan-Hong Zhou, Gui-Yuan Li

Human Pathology

DOI

2005

NGX6基因对高转移鼻咽癌细胞株5-8F细胞的影响

王莉莉，张秋红，马健，彭聪，曹利，唐珂，李小玲，李桂源

《生物化学与生物物理进展》

2005

NGX6对结肠癌细胞系HT-29基因表达谱的影响

刘芬，王晓艳，连平，肖志明，沈守荣，马健，熊炜

《癌症》

2002

利用动态等位基因特异性杂交技术进行单核苷酸多态高通量分型

曾朝阳，熊炜，沈守荣，朱诗国，李小玲，李伟芳，李江，周鸣，范松青，马健，周洁，肖炳燚，贺林，李桂源

《生物化学与生物物理进展》

2002

NGX6基因转染对鼻咽癌细胞基因表达谱的影响

马健，周洁，李小玲，龚佳蕾，何显锋，唐珂，阳剑波，胡赓熙，李桂源

《中国生物化学与分子生物学报》

2001

双向电泳和质谱技术研究鼻咽癌候选抑瘤基因NGX6的功能

李江，谭琛，向秋，张小梅，马健，李伟芳，王洁如，梁宋平，李桂源

《癌症》

2001

用双向电泳和质谱技术检测NGX6转染后人鼻咽癌细胞表达差异的蛋白质(英文)

李江，谭琛，向秋，张晓梅，马健，李伟芳，王洁如，阳剑波，梁宋平，李桂源

《生物化学与生物物理进展》

精选作品

期刊论文

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Building a Bridge Between the Mechanism of EBV Reactivation and the Treatment of EBV‐Associated Cancers

EB病毒的潜伏-裂解感染:调控机制与靶向策略

Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion

Epstein–Barr virus microRNA miR-BART2-5p accelerates nasopharyngeal carcinoma metastasis by suppressing RNase Ⅲ endonuclease DICER1

Liquid-liquid Phase Separation in Viral Function

Epstein–Barr virus EBNA2 phase separation regulates cancer‐associated alternative RNA splicing patterns

RNA m6A methylation regulates virus–host interaction and EBNA2 expression during Epstein–Barr virus infection

EBV as a high infection risk factor promotes RASSF10 methylation and induces cell proliferation in EBV-associated gastric cancer.

EBV‐miR‐BART12 accelerates migration and invasion in EBV‐associated cancer cells by targeting tubulin polymerization‐promoting protein 1

Phase Separation of Epstein-Barr Virus EBNA2 and Its Coactivator EBNALP Controls Gene Expression

Epstein–Barr virus miR-BART3-3p promotes tumorigenesis by regulating the senescence pathway in gastric cancer

Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression

Epstein-Barr Virus miR-BART6-3p Inhibits the RIG-I Pathway

Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103

Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1

EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC

SPLUNC1 reduces the inflammatory response of nasopharyngeal carcinoma cells infected with the EB virus by inhibiting the TLR9/NF-κB pathway.

PLUNC蛋白家族在抑制鼻咽上皮“炎-癌”演进中的作用和机制

一个肝癌相关长链非编码RNA的克隆及序列分析

Lactoferrin suppresses the Epstein–Barr virus-induced inflammatory response by interfering with pattern recognition of TLR2 and TLR9

染色质免疫沉淀-测序:全基因组范围研究蛋白质-DNA相互作用的新技术

天然免疫分子乳铁蛋白抑制鼻咽癌的发生发展

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Inhibition of Epstein-Barr Virus Infection by Lactoferrin

多基因遗传性肿瘤不同阶段转录组学调控规律及其分子机制

Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus

Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis.

NGX6基因对高转移鼻咽癌细胞株5-8F细胞的影响

NGX6对结肠癌细胞系HT-29基因表达谱的影响

利用动态等位基因特异性杂交技术进行单核苷酸多态高通量分型

NGX6基因转染对鼻咽癌细胞基因表达谱的影响

双向电泳和质谱技术研究鼻咽癌候选抑瘤基因NGX6的功能

用双向电泳和质谱技术检测NGX6转染后人鼻咽癌细胞表达差异的蛋白质(英文)

会议论文

Epstein-Barr virus protein EBNA2:phase separation,alternative RNA splicing,regulating virus-host interaction

SPLUNC 1通过TLR4信号通路抑制炎症参与鼻咽癌发生的机制研究

SPLUNC1通过TLR4信号通路抑制炎症参与鼻咽癌发生的机制研究

研究方向