张璐｜河南工业大学｜学者主页

2026

基于AMPK/mTOR自噬信号通路探讨芪苓健脾颗粒对阿霉素肾病大鼠足细胞损伤保护机制研究

魏锦慧，马鸿斌，张璐，张雪，高妍，马雪莉，何彩苹，柳振华，李旭萍，薛国忠，王庆苗

《中西医结合慢性病杂志》

2026

MTR4 : A Conserved Youth Factor for Vascular Endothelium

Zhenyuan Guo, Zhiqiang Chen, Jiaqi Sun, Xiaojun Zhou, Chengzhi Ni, Yuxiang Zhang, Pengfei Qiang, Lu Zhang

Aging Cell

DOI

2026

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium

Mengyu Li, Zhenyuan Guo, Yuwei Jiang, Lianghao Zhao, Yuxiang Zhang, Lingxin Meng, Chengzhi Ni, Zhiqiang Chen, Lu Zhang

Advanced Biology

DOI

2025

平喘宁方通过调控HMGB1/Beclin-1轴介导的自噬改善患寒哮证大鼠的气道炎症

王心恒，邵小涵，李童童，张璐，杨勤军，叶卫东，童佳兵，李泽庚，方向明

《南方医科大学学报》

2024

Lack of T04C9.1, the Homologue of Mammalian APPL2, Leads to Premature Ageing and Shortens Lifespan in Caenorhabditis elegans

Zirui Li, Zhiqiang Chen, Lianghao Zhao, Jiaqi Sun, Lin Yin, Yuwei Jiang, Xiaotong Shi, Ziye Song, Lu Zhang

Genes

DOI

2023

麻芍平喘汤通过PI3K/Akt/mTOR信号通路抑制气道上皮细胞自噬

任燕群，王小乐，刘桐，张璐，王心恒，吴迪，丁焕章，李泽庚

《中国实验方剂学杂志》

2023

CD44 connects autophagy decline and ageing in the vascular endothelium

Lu Zhang, Peichang Yang, Jingxuan Chen, Zhiqiang Chen, Zhihui Liu, Gaoqing Feng, Fangfang Sha, Zirui Li, Zaoyi Xu, Yating Huang, Xiaotong Shi, Xuebiao Li, Jiatian Cui, Chenyi Zhang, Pei Fan, Liuqing Cui, Yunpeng Shen, Guang‐Zhou Zhou, Hongjuan Jing, Shiwei Ma

Nature Communications

DOI

2022

CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer

Jingxuan Chen, Yunpeng Shen, Bowen Wu, Peichang Yang, Gang‐Chun Sun, Xiaoting Liu, Pengfei Qiang, Yamei Gao, Fangfang Sha, Zirui Li, Lu Zhang

Cell Death Discovery

DOI

2021

Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells

Zhihui Liu, Lu Zhang, Yachao Liu, Hanxiao Zhang, Jingxuan Chen, Gaoqing Feng, Peichang Yang, Fangfang Sha, Liuqing Cui, Gang‐Chun Sun

Life

DOI

2021

Polyethylenimine-Modified Mesoporous Silica Nanoparticles Induce a Survival Mechanism in Vascular Endothelial Cells via Microvesicle-Mediated Autophagosome Release

Lu Zhang, Gaoqing Feng, Shuoye Yang, Bin Liu, Yakun Niu, Pei Fan, Zhihui Liu, Jingxuan Chen, Liuqing Cui, Guang‐Zhou Zhou, Hongjuan Jing, Jing Liu, Yunpeng Shen

ACS Nano

DOI

2020

Mitophagy Improves Ethanol Tolerance in Yeast: Regulation by Mitochondrial Reactive Oxygen Species in Saccharomyces cerevisiae

Hongjuan Jing, Huanhuan Liu, Lu Zhang, Liuqing Cui, Xiaorong Tan

Journal of Microbiology and Biotechnology

DOI

2018

Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

Lu Zhang, Pengfei Qiang, JingTing Yu, Yiming Miao, Zhiqiang Chen, Ju Qu, Qianbing Zhao, Zhuo Chen, Yachao Liu, Xin Yao, Bin Liu, Liuqing Cui, Hongjuan Jing, Gang‐Chun Sun

Autophagy

DOI

2018

Ethanol induces autophagy regulated by mitochondrial ROS in Saccharomyces cerevisiae

Hongjuan Jing, Huanhuan Liu, Lu Zhang, Jie Gao, Haoran Song, Xiaorong Tan

Journal of Microbiology and Biotechnology

DOI

2017

Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells

Lu Zhang, Fang Dai, Liuqing Cui, Bo Zhou, Yuqi Guo

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2016

Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia

Pengwei Zhuang, Jinbao Zhang, Yan Wang, Mixia Zhang, Lili Song, Zhiqiang Lu, Lu Zhang, Fengqi Zhang, Jing Wang, Yanjun Zhang, Hongjun Wei, Hongyan Li

Supportive Care In Cancer，Vol. 24, No. 3

DOI

2014

Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells

Lu Zhang, Fang Dai, Liuqing Cui, Hongjuan Jing, Pei Fan, Xiaorong Tan, Yuqi Guo, Guang‐Zhou Zhou

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2012

Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells

Lu Zhang, Liuqing Cui, Guang‐Zhou Zhou, Hongjuan Jing, Yuqi Guo, Wenkai Sun

The Journal of Nutritional Biochemistry

DOI

张璐

精选作品

期刊论文

基于AMPK/mTOR自噬信号通路探讨芪苓健脾颗粒对阿霉素肾病大鼠足细胞损伤保护机制研究

MTR4 : A Conserved Youth Factor for Vascular Endothelium

Loss of BCAP31 or POLR1E Accelerates Aging in C. elegans and is Linked to Senescence in Vascular Endothelium

平喘宁方通过调控HMGB1/Beclin-1轴介导的自噬改善患寒哮证大鼠的气道炎症

Lack of T04C9.1, the Homologue of Mammalian APPL2, Leads to Premature Ageing and Shortens Lifespan in Caenorhabditis elegans

麻芍平喘汤通过PI3K/Akt/mTOR信号通路抑制气道上皮细胞自噬

CD44 connects autophagy decline and ageing in the vascular endothelium

CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer

Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells

Polyethylenimine-Modified Mesoporous Silica Nanoparticles Induce a Survival Mechanism in Vascular Endothelial Cells via Microvesicle-Mediated Autophagosome Release

Mitophagy Improves Ethanol Tolerance in Yeast: Regulation by Mitochondrial Reactive Oxygen Species in Saccharomyces cerevisiae

Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer

Ethanol induces autophagy regulated by mitochondrial ROS in Saccharomyces cerevisiae

Up-regulation of the active form of small GTPase Rab13 promotes macroautophagy in vascular endothelial cells

Reversal of muscle atrophy by Zhimu and Huangbai herb pair via activation of IGF-1/Akt and autophagy signal in cancer cachexia

Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells

Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells

研究方向