赵炜｜南开大学｜学者主页

2026

Chemical proteomics and phenotypic profiling identify αFOD as a podophyllotoxin-derived PGK1 inhibitor that suppresses glycolysis and proliferation in hepatocellular carcinoma.

Run-Hua Liu, Xi Chen, Hong-Mei Li, Wei Zhao, Jian-Jiang Zhong, Ya-Jie Tang

Biochemical Pharmacology

DOI

2026

Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.

Malik Sadaf Ali, Wei Zhao, Hong-Mei Li, Jing-Yuan Cong, Ya-Jie Tang

International Journal of Biological Macromolecules

DOI

2026

FBX-DMEP suppresses hepatocellular carcinoma through tubulin-associated mitotic dysregulation

Run-Hua Liu, Hong-Mei Li, Wei Zhao, Jian-Jiang Zhong, Ya-Jie Tang

Journal of Translational Internal Medicine

DOI

2026

Dual Innovations Driving Pseudomonas aeruginosa Lipopolysaccharide Core Pentasaccharide Synthesis: Linker Configuration Control and One-Pot Bis-glycosylation

Ke Feng, Xianwei Ding, J T Liu, Yi Zhou, Haoyu Xue, Yongmei Yin, Hongzhen Jin, Wei Zhao

Organic Letters

DOI

2024

Podophyllotoxin derivatives-tubulin complex reveals a potential binding site of tubulin polymerization inhibitors in α-tubulin adjacent to colchicine site.

Wei Zhao, Rong Shen, Hong-Mei Li, Jian-Jiang Zhong, Ya-Jie Tang

International Journal of Biological Macromolecules

DOI

2021

[Research progress in biosynthesis of podophyllotoxin and its derivatives].

Z. Meng, Ting-Ting Yao, Wei Zhao, Hong-Mei Li, Ya-Jie Tang

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2021

Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133.

Wei Zhao, Ying Duan, Hong-Mei Li, Shengying Li, Yue-Mao Shen, You-Ming Zhang, Yue-Zhong Li, Ya-Jie Tang

European Journal of Pharmacology

DOI

2020

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy.

Wei Zhao, Y. Cong, Hong-Mei Li, Shengying Li, Yue-Mao Shen, Q. Qi, You-Ming Zhang, Yue-Zhong Li, Ya-Jie Tang

Natural product reports (Print)

DOI

2020

Discover 4,6-O-thenylidene-β-D-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as potential less toxic antitumor candidate drugs by reducing DNA damage and less inhibition of PI3K.

Jie Cheng, Wei Zhao, Hui Yao, Yue-Mao Shen, You-Ming Zhang, Yue-Zhong Li, Q. Qi, K. Wongprasert, Ya-Jie Tang

Journal of Medicinal Chemistry

DOI

2019

2-氰基苄基诱导的葡萄糖醛酸β糖苷键立体选择性

张岩岩，郝凯风，张国强，赵炜

《高等学校化学学报》

2019

Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.

Wei Zhao, Long He, Tian-Le Xiang, Ya-Jie Tang

European journal of medicinal chemistry

DOI

2018

Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4'-demethylepipodophyllotoxin.

Qing-yun Zhang, Wei Zhao, Ya-Jie Tang

European journal of medicinal chemistry

DOI

2017

Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.

Wei Zhao, Chen Zhou, Z. Guan, P. Yin, Fu-Sheng Chen, Ya-Jie Tang

ACS Chemical Biology

DOI

2016

Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

Ya-Xuan Zhang, Wei Zhao, Ya-Jie Tang

OncoTarget

DOI

2015

不同溶剂中氟原子对糖苷键立体选择性的影响

韩小见，王佳佳，万玥，赵云燕，赵炜

《化学通报(中英文)》

2015

Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity

Jian-long Li, Wei Zhao, Chen Zhou, Ya-Xuan Zhang, Hong-Mei Li, Yanquan Tang, Xin-Hua Liang, Tao Chen, Yanyan Tang

Scientific Reports

DOI

2015

Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells

Wei Zhao, Yong Yang, Ya-Xuan Zhang, Chen Zhou, Hong-Mei Li, Yanquan Tang, Xin-Hua Liang, Tao Chen, Yanyan Tang

Scientific Reports

DOI

2015

Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity

Wei Zhao, J-K Bai, Hong-Mei Li, Tao Chen, Yanyan Tang

Scientific Reports

DOI

2014

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.

Wei Zhao, Lu-Ping Chen, Hong-Mei Li, Duan Wang, Dong-Sheng Li, Tao Chen, Zhan-Peng Yuan, Ya-Jie Tang

Bioorganic & Medicinal Chemistry

DOI

2014

Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.

Li Xiao, Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Dong-Sheng Li, Tao Chen, Ya-Jie Tang

European journal of medicinal chemistry

DOI

2012

Optimization of a biotransformation process to produce 4-(2,3,5,6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin

Wei Zhao, Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Duan-Ji Wan, Ya-Jie Tang

DOI

2011

Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source

Wei Zhao, Hong-Mei Li, Duan-Ji Wan, Ya-Jie Tang

Applied Microbiology and Biotechnology

DOI

2011

Novel Tandem Biotransformation Process for the Biosynthesis of a Novel Compound, 4-(2,3,5,6-Tetramethylpyrazine-1)-4′-Demethylepipodophyllotoxin

Ya-Jie Tang, Wei Zhao, Hong-Mei Li

Applied and Environmental Microbiology

DOI

赵炜

精选作品

期刊论文

Chemical proteomics and phenotypic profiling identify αFOD as a podophyllotoxin-derived PGK1 inhibitor that suppresses glycolysis and proliferation in hepatocellular carcinoma.

Thiadiazole-4β-sulfur-demethylepipodophyllotoxin traps human topoisomerase IIβ by distorting DNA and disrupting the tyrosyl-DNA linkage.

FBX-DMEP suppresses hepatocellular carcinoma through tubulin-associated mitotic dysregulation

Dual Innovations Driving Pseudomonas aeruginosa Lipopolysaccharide Core Pentasaccharide Synthesis: Linker Configuration Control and One-Pot Bis-glycosylation

Podophyllotoxin derivatives-tubulin complex reveals a potential binding site of tubulin polymerization inhibitors in α-tubulin adjacent to colchicine site.

[Research progress in biosynthesis of podophyllotoxin and its derivatives].

Triazole/thiadiazole substituted 4'-demethylepipodophyllotoxin derivatives induced apoptosis in HeLa cells by up-regulating TMEM133.

Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy.

Discover 4,6-O-thenylidene-β-D-glucopyranoside-(2″-acetamido, 3″-acetyl-di-S-5-fluorobenzothizole/5-fluorobenzoxazole)-4'-demethylepipodophyllotoxin as potential less toxic antitumor candidate drugs by reducing DNA damage and less inhibition of PI3K.

2-氰基苄基诱导的葡萄糖醛酸β糖苷键立体选择性

Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.

Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4'-demethylepipodophyllotoxin.

Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4β-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.

Multilevel induction of apoptosis by microtubule-interfering inhibitors 4β-S-aromatic heterocyclic podophyllum derivatives causing multi-fold mitochondrial depolarization and PKA signaling pathways in HeLa cells

不同溶剂中氟原子对糖苷键立体选择性的影响

Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity

Fluoride-containing podophyllum derivatives exhibit antitumor activities through enhancing mitochondrial apoptosis pathway by increasing the expression of caspase-9 in HeLa cells

Tubulin structure-based drug design for the development of novel 4β-sulfur-substituted podophyllum tubulin inhibitors with anti-tumor activity

A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.

Design and synthesis of the novel DNA topoisomerase II inhibitors: esterification and amination substituted 4'-demethylepipodophyllotoxin derivates exhibiting anti-tumor activity by activating ATM/ATR signaling pathways.

Optimization of a biotransformation process to produce 4-(2,3,5,6-tetramethylpyrazine-1)-4′-demethylepipodophyllotoxin

Manipulation of heterogeneity product in 4′-demethylepipodophyllotoxin biotransformation process by using yeast extract as nitrogen source

Novel Tandem Biotransformation Process for the Biosynthesis of a Novel Compound, 4-(2,3,5,6-Tetramethylpyrazine-1)-4′-Demethylepipodophyllotoxin

会议论文

基于FSL-1佐剂的糖肽抗肿瘤疫苗研究

Preactivation-Based,One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux Sodium

Immunological evaluation of MUC1-based antitumor vaccines with the adjuvant of α-galactosylceramide presented by gold nanoparticles

An New Era of Carbohydrate Chemistry:Synthetic Large Glycoconjugates and Synthetic Glycomes

具有生物活性的寡糖及糖肽的合成研究

研究方向