百晓学者学者目录

张雪梅

副教授、教授、讲师，重庆医科大学

精选作品

期刊论文

2026

华蟾素的主要活性成分通过激活巨噬细胞cGAS-STING信号通路抑制肝癌进展

俞诗涵，张雪梅，石佳，郑文澜，郑力铭，刘浩，冯海，余卓

《上海中医药杂志》

DOI

2025

Targeting TLR7 reprograms macrophage function to attenuate influenza-associated Staphylococcus aureus coinfection

Te Chen, Jiayu Liu, Renlin Yu, Xinyu Wu, Qin Luo, Haofeng Xu, Wenchun Xu, Xuemei Zhang, Yibing Yin

Microbial Pathogenesis

DOI

2025

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppression

Kai Chen, Ying Hu, Xiaoyan Yu, Hong Tang, Yanting Ruan, Yue Li, Xun Gao, Qing Zhao, Hong Wang, Xuemei Zhang, David Paul Molloy, Yibing Yin, Dapeng Chen, Zhixin Song

Journal of Clinical Investigation

DOI

2025

Activin A exacerbates neonatal necrotizing enterocolitis via ALK4-mediated apoptosis and barrier disruption

Wenjing Ma, Jiali Xie, Lu Liu, Xi Yuan, Xiaoyan Yu, Kai Chen, Yue Li, Wei Liu, Xuemei Zhang, Dapeng Chen, Zhixin Song

International Immunopharmacology

DOI

2025

The global transcriptional regulator MgaSpn affects the virulence of Streptococcus pneumoniae by regulating PcpA

Shuhui Wang, Tianyi Xu, Ye Tao, Lei Li, Xuemei Zhang, Yibing Yin, Yuqiang Zheng

BMC Microbiology

DOI

2025

SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in Streptococcus pneumoniae D39

Ye Tao, Lei Li, Shuhui Wang, Xuemei Zhang, Yibing Yin, Yuqiang Zheng

Frontiers in Microbiology

DOI

2024

FGF8 Protects Against Polymicrobial Sepsis by Enhancing the Host's Anti-infective Immunity

Kai Chen, Yanting Ruan, Wenjing Ma, Xiaoyan Yu, Ying Hu, Yue Li, Hong Tang, Xuemei Zhang, Yibing Yin, Dapeng Chen, Zhixin Song

The Journal of Infectious Diseases

DOI

2024

Immunization with recombinant Streptococcus pneumoniae PgdA protects mice against lung invasion

Jiangming Xiao, Bichen Liu, Yibing Yin, Xuemei Zhang

Experimental Biology and Medicine

DOI

2024

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis

Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang

Free Radical Biology and Medicine

DOI

2024

Transcriptional regulation of TacL-mediated lipoteichoic acids biosynthesis by ComE during competence impacts pneumococcal transformation

Miao Yao, Kun Wang, Song Guang-ming, Yumeng Hu, Jiali Chen, Tingting Li, Longying Liang, Jie Wu, Hongmei Xu, Libin Wang, Yuqiang Zheng, Xuemei Zhang, Yin Yibing, Shifei Yao, Kaifeng Wu

Frontiers in Cellular and Infection Microbiology

DOI

2024

Streptococcus pneumoniae endopeptidase O induces trained immunity and confers protection against various pathogenic infections

Wenlong Xu, Yuan Yuan, Zhaoche Shu, Ting Guo, Bichen Liu, Jiangming Xiao, Lian Li, Yibin Yin, Xuemei Zhang

Clinical Immunology

DOI

2023

The preprogrammed anti-inflammatory phenotypes of CD11chigh macrophages by Streptococcus pneumoniae aminopeptidase N safeguard from allergic asthma

Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu

Journal of Translational Medicine

DOI

2023

Detoxified pneumolysin derivative ΔA146Ply inhibits triple- negative breast cancer metastasis mainly via mannose receptor-mediated autophagy inhibition

Hong Zhang, Tao Zhu, Wenchun Xu, Bichen Liu, Kaifeng Wu, Yibing Yin, Xuemei Zhang

Virulence

DOI

2023

The Streptococcus virulence protein PepO triggers anti-tumor immune responses by reprograming tumor-associated macrophages in a mouse triple negative breast cancer model

Bichen Liu, Jun Huang, Jiangming Xiao, Wenlong Xu, Hong Zhang, Yuan Yuan, Yibing Yin, Xuemei Zhang

Cell & Bioscience

DOI

2023

ΔA146Ply-HA stem protein immunization protects mice against influenza A virus infection and co-infection with Streptococcus pneumoniae

Lian Li, Ting Guo, Yuan Yuan, Jiangming Xiao, Rui Yang, Hanyi Wang, Wenlong Xu, Yibing Yin, Xuemei Zhang

Molecular Immunology

DOI

2023

IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells

Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu

iScience

DOI

2023

Identification of cis-acting elements upstream of regR gene in streptococcus pneumoniae

Jiangming Xiao, Yapeng Zhang, Jinghui Zhang, Jinghui Zhang, Jinghui Zhang, Bichen Liu, HanYi Wang, Rui Yang, Yibing Yin, Xuemei Zhang

Microbial Pathogenesis

DOI

2023

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39

Yapeng Zhang, Jinghui Zhang, Jiangming Xiao, Hanyi Wang, Rui Yang, Xinlin Guo, Yuqiang Zheng, Yibing Yin, Xuemei Zhang

Microbiology Spectrum

DOI

2022

Glucose levels affect MgaSpn regulation on the virulence and adaptability of Streptococcus pneumoniae

Weicai Suo, Xinlin Guo, Xuemei Zhang, Shengnan Xiao, Shuhui Wang, Yibing Yin, Yuqiang Zheng

Microbial Pathogenesis

DOI

2022

rM2e-ΔPly protein immunization induces protection against influenza viruses and its co-infection with Streptococcus pneumoniae in mice

Ting Guo, Jiangming Xiao, Lian Li, Wenlong Xu, Yuan Yuan, Yibing Yin, Xuemei Zhang

Molecular Immunology

DOI

2022

CD5L attenuates allergic airway inflammation by expanding CD11chigh alveolar macrophages and inhibiting NLRP3 inflammasome activation via HDAC2

Danlin Weng, Song Gao, Hailan Shen, Shifei Yao, Qi Huang, Yanyu Zhang, Wenjie Huang, Yan Wang, Xuemei Zhang, Yibing Yin, Wenchun Xu

Immunology

DOI

2022

Detoxified pneumolysin derivative ΔA146Ply inhibits autophagy and induces apoptosis in acute myeloid leukemia cells by activating mTOR signaling

Tao Zhu, Hong Zhang, Sijie Li, Kaifeng Wu, Yibing Yin, Xuemei Zhang

Experimental & Molecular Medicine

DOI

2022

Novel Therapeutic Targeting of CCL3-CCR4 Axis Mediated Apoptotic Intesitnal Injury in Necrotizing Enterocolitis

Xi Yuan, Zihan Xiong, Wei Liu, Yue Li, Hongdong Li, Xuemei Zhang, Yibing Yin, Pingyong Xu, Ju Cao, Dapeng Chen, Zhixin Song

Frontiers in Immunology

DOI

2022

IL-6 Prevents Lung Macrophage Death and Lung Inflammation Injury by Inhibiting GSDME- and GSDMD-Mediated Pyroptosis during Pneumococcal Pneumosepsis

Xuemei Gou, Wenchun Xu, Yusi Liu, Peng Yang, Wenlong Xu, Yibing Yin, Xuemei Zhang

Microbiology Spectrum

DOI

2022

IL-4 plays an essential role in DnaJ-ΔA146Ply-mediated immunoprotection against Streptococcus pneumoniae in mice

Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Peng Yang, Yusi Liu, Yibing Yin, Xuemei Zhang

Molecular Immunology

DOI

2021

Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages

Sijia Cao, Xiaoyun Dou, Xuemei Zhang, Yuting Fang, Zihan Yang, Yinting Jiang, Xiaoling Hao, Ziyuan Zhang, Hong Wang

Molecular Immunology

DOI

2021

IL-27 as a potential biomarker for distinguishing between necrotising enterocolitis and highly suspected early-onset food protein-induced enterocolitis syndrome with abdominal gas signs

Yuhong Qi, Chan Liu, Xin Zhong, Xueling Ma, Jie Zhou, Yuan Shi, Yibing Yin, Xuemei Zhang, Yu He, Wenchun Xu

EBioMedicine

DOI

2021

Mga Spn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39

Shengnan Xiao, Weicai Suo, Jinghui Zhang, Xuemei Zhang, Yibing Yin, Xinlin Guo, Yuqiang Zheng

Virulence

DOI

2021

Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae

Jinghui Zhang, Weijie Ye, Kaifeng Wu, Shengnan Xiao, Yuqiang Zheng, Zhaoche Shu, Yibing Yin, Xuemei Zhang

mBio

DOI

2021

Biomineralization Improves The Stability of A Streptococcus Pneumoniae Protein Vaccine at High Temperatures

Yajun Min, Wenchun Xu, Yunju Xiao, Jiangming Xiao, Zhaoche Shu, Sijie Li, Jinghui Zhang, Yusi Liu, Yibing Yin, Xuemei Zhang, Jiangping Meng

Nanomedicine

DOI

2021

Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia

Peng Yang, Xiaofang Wang, Hong Wang, Wenchun Xu, Kaifeng Wu, Xuemei Go, Yibing Yin, Xuemei Zhang

Clinical & Experimental Immunology

DOI

2021

Protective efficacy of mucosal and subcutaneous immunization with DnaJ-ΔA146Ply against influenza and Streptococcus pneumoniae co-infection in mice

Yi Hu, Yusi Liu, Yibing Yin, Xuemei Zhang

Microbes and Infection

DOI

2020

肺炎链球菌pcsB组成型表达的yycF缺陷菌株的构建及其致病能力

肖云菊，张竞辉，肖胜楠，尹一兵，张雪梅

《微生物学通报》

DOI

2020

融合蛋白DnaJ-ΔA146Ply对小鼠肺炎链球菌脑膜炎感染的保护效果

王婧瑶，肖江明，刘宇思，尹一兵，张雪梅

《免疫学杂志》

DOI

2020

IL-33 synergistically promotes the proliferation of lung cancer cells in vitro by inducing antibacterial peptide LL-37 and proinflammatory cytokines in macrophages

Yinting Jiang, Hongyi Liao, Xuemei Zhang, Sijia Cao, Xuexue Hu, Zihan Yang, Yuting Fang, Hong Wang

Immunobiology

DOI

2020

Streptococcus pneumoniae aminopeptidase N regulates dendritic cells that attenuates type‐2 airway inflammation in murine allergic asthma

Guangying Wu, Xuemei Zhang, Xu Chen, Jian Wang, Jing Yang, Ling Wang, Si Sun, Yuhong Qi, Hong Wang, Yibing Yin, Wenchun Xu

British Journal of Pharmacology

DOI

2020

Streptococcus pneumoniae Endopeptidase O Promotes the Clearance of Staphylococcus aureus and Streptococcus pneumoniae via SH2 Domain-Containing Inositol Phosphatase 1-Mediated Complement Receptor 3 Upregulation

Sijie Li, Hong Zhang, Jiangming Xiao, Taixian Yuan, Zhaoche Shu, Yajun Min, Wenchun Xu, Yibing Yin, Xuemei Zhang

Frontiers in Cellular and Infection Microbiology

DOI

2020

Combination of Detoxified Pneumolysin Derivative ΔA146Ply and Berbamine as a Treatment Approach for Breast Cancer

Hong Zhang, Tao Zhu, Ruoqiu Fu, Peng Yang, Jing Peng, Wenchun Xu, Hong Wang, Sijie Li, Zhaoche Shu, Yibing Yin, Xuemei Zhang

Molecular Therapy — Oncolytics

DOI

2020

Cytosolic mtDNA released from pneumolysin-damaged mitochondria triggers IFN-β production in epithelial cells

Yuting Fang, Xuemei Zhang, Chang Lu, Yibing Yin, Xuexue Hu, Wenchun Xu, Yusi Liu, Hong Zhang

Canadian Journal of Microbiology

DOI

2020

Streptococcus pneumoniae PepO promotes host anti-infection defense via autophagy in a Toll-like receptor 2/4 dependent manner

Zhaoche Shu, Jun Yuan, Hong Wang, Jinghui Zhang, Sijie Li, Hong Zhang, Yusi Liu, Yibing Yin, Xuemei Zhang

Virulence

DOI

2020

Streptococcus pneumoniae aminopeptidase N contributes to bacterial virulence and elicits a strong innate immune response through MAPK and PI3K/AKT signaling

Ling Wang, Xuemei Zhang, Guangying Wu, Yuhong Qi, Jinghui Zhang, Jing Yang, Hong Zhang, Wenchun Xu

The Journal of Microbiology

DOI

2020

IL-6 During Influenza-Streptococcus pneumoniae Co-Infected Pneumonia—A Protector

Xuemei Gou, Jun Yuan, Hong Wang, Xiaofang Wang, Jiangming Xiao, Jingyi Chen, Shuang Liu, Yibing Yin, Xuemei Zhang

Frontiers in Immunology

DOI

2019

肺炎链球菌LytR蛋白影响细菌生长和磷壁酸的合成

叶唯洁，徐红梅，张竞辉，张雪梅，尹一兵，吴凯峰

《基因组学与应用生物学》

DOI

2019

Progranulin Mediates Proinflammatory Responses in Systemic Lupus Erythematosus: Implications for the Pathogenesis of Systemic Lupus Erythematosus

Chunmei Jing, Xuemei Zhang, Zhixin Song, Yuqiang Zheng, Yibing Yin

Journal of Interferon & Cytokine Research

DOI

2019

Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection

Xiaofang Wang, Jun Yuan, Hong Wang, Ning Gan, Qun Zhang, Bichen Liu, Jingyao Wang, Zhaoche Shu, Lubei Rao, Xuemei Gou, Hong Zhang, Yibing Yin, Xuemei Zhang

The Journal of Immunology

DOI

2019

Type I IFN expression is stimulated by cytosolic Mt DNA released from pneumolysin‐damaged mitochondria via the STING signaling pathway in macrophages

Xuexue Hu, Xiaoqiong Peng, Chang Lu, Xuemei Zhang, Lingling Gan, Yue Gao, Shenghui Yang, Wenchun Xu, Jian Wang, Yibing Yin, Hong Wang

FEBS Journal

DOI

2019

Type I interferon induced by DNA of nontypeable Haemophilus influenza modulates inflammatory cytokine profile to promote susceptibility to this bacterium

Shenghui Yang, Yibing Yin, Wenchun Xu, Xuemei Zhang, Yue Gao, Hongyi Liao, Xuexue Hu, Jian Wang, Hong Wang

International Immunopharmacology

DOI

2019

Progranulin Promotes Bleomycin-Induced Skin Sclerosis by Enhancing Transforming Growth Factor–β/Smad3 Signaling through Up-Regulation of Transforming Growth Factor–β Type I Receptor

Ting Yang, Xuemei Zhang, Aijun Chen, Yunju Xiao, Si Sun, Jurong Yan, Yuwei Cao, Jin Chen, Feng‐Zeng Li, Qun Zhang, Kun Huang

American Journal Of Pathology

DOI

2019

Mitochondrial DNA Leakage Caused by Streptococcus pneumoniae Hydrogen Peroxide Promotes Type I IFN Expression in Lung Cells

Yue Gao, Wenchun Xu, Xiaoyun Dou, Hong Wang, Hong Wang, Xuemei Zhang, Shenghui Yang, Hongyi Liao, Xuexue Hu, Hong Wang, Hong Wang

Frontiers in Microbiology

DOI

2019

Mast cell degranulation impairs pneumococcus clearance in mice via IL-6 dependent and TNF-α independent mechanisms

Jing Yang, Jichao Wang, Xuemei Zhang, Yulan Qiu, Jurong Yan, Si Sun, Yujuan He, Yibing Yin, Wenchun Xu

World Allergy Organization Journal

DOI

2019

miR-29b Reverses T helper 1 cells/T helper 2 cells Imbalance and Alleviates Airway Eosinophils Recruitment in OVA-Induced Murine Asthma by Targeting Inducible Co-Stimulator

Jurong Yan, Xuemei Zhang, Si Sun, Ting Yang, Jing Yang, Guangying Wu, Yulan Qiu, Yibing Yin, Wenchun Xu

International Archives of Allergy and Immunology

DOI

2018

肺炎链球菌ΔA146Ply蛋白抵抗鼻咽部感染的研究

吴静雯，王箭，王继超，王晓芳，张雪梅

《基因组学与应用生物学》

2018

肺炎链球菌MarR家族蛋白SPD0379通过调节基因rafX的表达调控磷壁酸的合成

张竞辉，叶唯洁，张雪梅，尹一兵，孟江萍

《重庆医科大学学报》

2018

Pneumococcal LytR Protein Is Required for the Surface Attachment of Both Capsular Polysaccharide and Teichoic Acids: Essential for Pneumococcal Virulence

Weijie Ye, Jinghui Zhang, Zhaoche Shu, Yibing Yin, Xuemei Zhang, Kaifeng Wu

Frontiers in Microbiology

DOI

2018

spd1672, a novel in vivo-induced gene, affects inflammatory response in a murine model of Streptococcus pneumoniae infection

Lingling Gan, Xuemei Zhang, Xiuyu Xu, Wenchun Xu, Chang Lu, Jin Cui, Hong Wang

Canadian Journal of Microbiology

DOI

2018

Nontypeable Haemophilus influenzae DNA stimulates type I interferon expression via STING signaling pathway

Chang Lu, Xuemei Zhang, Chenyu Ma, Wenchun Xu, Lingling Gan, Jin Cui, Yibing Yin, Hong Wang

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2018

Streptococcus pneumoniae Attenuated Strain SPY1 with an Artificial Mineral Shell Induces Humoral and Th17 Cellular Immunity and Protects Mice against Pneumococcal Infection

Xinyuan Zhang, Jingjing Cui, Yingying Wu, Hong Wang, Jian Wang, Yulan Qiu, Yunjun Mo, Yujuan He, Xuemei Zhang, Yibing Yin, Wenchun Xu

Frontiers in Immunology

DOI

2017

Expression of Toll-Like Receptor 2 by Dendritic Cells Is Essential for the DnaJ-ΔA146Ply-Mediated Th1 Immune Response against Streptococcus pneumoniae

Xiaofang Wang, Taixian Yuan, Jun Yuan, Yufeng Su, Xiaoyu Sun, Jingwen Wu, Hong Zhang, Xun Min, Xuemei Zhang, Yibing Yin

Infection and Immunity

DOI

2017

Engineering detoxified pneumococcal pneumolysin derivative ΔA146PLY for self-biomineralization of calcium phosphate: Assessment of their protective efficacy in murine infection models

Jingwen Wu, Kaifeng Wu, Wenchun Xu, Taixian Yuan, Xiaofang Wang, Jinghui Zhang, Yajun Min, Yibing Yin, Xuemei Zhang

Biomaterials

DOI

2017

Heterologous prime-boost immunization with live SPY1 and DnaJ protein of Streptococcus pneumoniae induces strong Th1 and Th17 cellular immune responses in mice

Yulan Qiu, Xuemei Zhang, Hong Wang, Xinyuan Zhang, Yunjun Mo, Xiaoyu Sun, Jichao Wang, Yibing Yin, Wenchun Xu

The Journal of Microbiology

DOI

2017

Interleukin-17A Aggravates Middle Ear Injury Induced by Streptococcus pneumoniae through the p38 Mitogen-Activated Protein Kinase Signaling Pathway

Wei J. Wang, Wenbin Liu, Jiali Liu, Zimeng Wang, Fangmei Fan, Yurong Ma, Chunfang Jin, Yun Xiang, Yifei Huang, Xuemei Zhang, Wenchun Xu, Yibing Yin, Yujuan He

Infection and Immunity

DOI

2017

Subcutaneous Immunization with Fusion Protein DnaJ-ΔA146Ply without Additional Adjuvants Induces both Humoral and Cellular Immunity against Pneumococcal Infection Partially Depending on TLR4

Yu‐Feng Su, Dagen Li, Yan Xing, Hong Wang, Jian Wang, Jun Yuan, Xiaofang Wang, Fang Cui, Yibing Yin, Xuemei Zhang

Frontiers in Immunology

DOI

2017

ComE, an Essential Response Regulator, Negatively Regulates the Expression of the Capsular Polysaccharide Locus and Attenuates the Bacterial Virulence in Streptococcus pneumoniae

Yuqiang Zheng, Xuemei Zhang, Xiaofang Wang, Libin Wang, Jinghui Zhang, Yibing Yin

Frontiers in Microbiology

DOI

2017

The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media

Yun Xiang, Chunfang Jin, Wei Wang, Zimeng Wang, Yifei Huang, Fangmei Fan, Yurong Ma, Xuemei Zhang, Wenchun Xu, Yibing Yin, Yujuan He

Innate Immunity

DOI

2017

Purified Streptococcus pneumoniae Endopeptidase O (PepO) Enhances Particle Uptake by Macrophages in a Toll-Like Receptor 2- and miR-155-Dependent Manner

Hua Chuan Yao, Hong Zhang, Kai Lan, Hong Zhang, Yufeng Su, Dagen Li, Zhixin Song, Fang Cui, Yibing Yin, Xuemei Zhang

Infection and Immunity

DOI

2017

DnaJ (hsp40) of Streptococcus pneumoniae is involved in bacterial virulence and elicits a strong natural immune reaction via PI3K/JNK

Jin Cui, Chenyu Ma, Guo Ye, Yong Shi, Wenchun Xu, Liang Zhong, Jian Wang, Yibing Yin, Xuemei Zhang, Hong Wang

Molecular Immunology

DOI

2017

Subcutaneous immunization with Streptococcus pneumoniae GAPDH confers effective protection in mice via TLR2 and TLR4

Xiaoyu Sun, Jichao Wang, Jie Zhou, Hong Wang, Xiaofang Wang, Jingwen Wu, Yujuan He, Yibing Yin, Xuemei Zhang, Wenchun Xu

Molecular Immunology

DOI

2017

Establishment of a rapid and sensitive method based on recombinase polymerase amplification to detect mts90, a new molecular target of Mycobacterium tuberculosis

Yunjun Mo, Fang Cui, Dairong Li, Yi Dai, Xinmin Li, Xinyuan Zhang, Yulan Qiu, Yibing Yin, Xuemei Zhang, Wenchun Xu

RSC Advances

DOI

2017

Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma

Ning Gan, Sihai Zou, Wenming Hang, Deqin Yang, Xuemei Zhang, Yibing Yin

Journal of Cancer

DOI

2016

PepO通过上调腹腔巨噬细胞中MircroRNA-155的表达来抑制IL-6的产生

姚华，张红，吴静雯，王晓芳，张雪梅

《基因组学与应用生物学》

2016

流感嗜血杆菌D蛋白黏膜免疫保护效果研究

邢燕，王建敏，粟玉凤，王虹，崔鲂，张雪梅，孟江萍

《免疫学杂志》

2016

肺炎链球菌候选蛋白疫苗DnaJ-△A146Ply通过PI3K/Akt和NF-κB信号通路刺激巨噬细胞诱导免疫应答

粟玉凤，李达根，邢燕，姚华，吴静雯，张雪梅

《基因组学与应用生物学》

2016

Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway

Yingying Wu, Jingjing Cui, Xuemei Zhang, Song Gao, Feng Ma, Hua Chuan Yao, Xiaoyu Sun, Yujuan He, Yibing Yin, Wenchun Xu

Immunobiology

DOI

2016

Attenuated Streptococcus pneumoniae vaccine candidate SPY1 promotes dendritic cell activation and drives a Th1/Th17 response

Song Gao, Lingbin Zeng, Xuemei Zhang, Yingying Wu, Jingjing Cui, Zhixin Song, Xiaoyu Sun, Hong Zhang, Yibing Yin, Wenchun Xu

Immunology Letters

DOI

2016

SCCmec-associated psm-mec mRNA promotes Staphylococcus epidermidis biofilm formation

Yongchang Yang, Xuemei Zhang, Wenfang Huang, Yibing Yin

Antonie van Leeuwenhoek

DOI

2016

TLR2 promotes macrophage recruitment and Streptococcus pneumoniae clearance during mouse otitis media

Yifei Huang, Zimeng Wang, Chunfang Jin, Lei Wang, Xuemei Zhang, Wenchun Xu, Yun Xiang, Wei J. Wang, Xiujing He, Yibing Yin, Yujuan He

Pediatric Research

DOI

2016

CpsR, a GntR family regulator, transcriptionally regulates capsular polysaccharide biosynthesis and governs bacterial virulence in Streptococcus pneumoniae

Kaifeng Wu, Hongmei Xu, Yuqiang Zheng, Libin Wang, Xuemei Zhang, Yibing Yin

Scientific Reports

DOI

2016

Progranulin Plays a Central Role in Host Defense during Sepsis by Promoting Macrophage Recruitment

Zhixin Song, Xuemei Zhang, Liping Zhang, Fang Xu, Xintong Tao, Hua Zhang, Xue Lin, Lihua Kang, Yu Xiang, Xaiofei Lai, Qun Zhang, Kun Huang, Yubing Dai, Yibing Yin, Ju Cao

American Journal of Respiratory and Critical Care Medicine

DOI

2016

Molecular epidemiology of pneumococcal isolates from children in China

Li-Hua Kang, Meng-Juan Liu, Wenchun Xu, Jingjing Cui, Xuemei Zhang, Kaifeng Wu, Qun Zhang

Saudi Medical Journal

DOI

2016

Streptococcus pneumoniae Endopeptidase O (PepO) Elicits a Strong Innate Immune Response in Mice via TLR2 and TLR4 Signaling Pathways

Hong Zhang, Lihua Kang, Hua Chuan Yao, Yujuan He, Xiaofang Wang, Wenchun Xu, Zhixin Song, Yibing Yin, Xuemei Zhang

Frontiers in Cellular and Infection Microbiology

DOI

2015

肺炎链球菌烯醇化酶与热休克蛋白DnaJ的结合及结合位点鉴定

王建敏，马峰，徐红梅，王丽滨，邢燕，粟玉凤，张雪梅，王虹

《重庆医科大学学报》

2015

肺炎链球菌cps操纵子的启动子序列点突变可导致细菌荚膜缺失

王建敏，徐绣宇，马峰，徐红梅，王丽滨，邢燕，粟玉凤，张雪梅

《微生物学报》

2015

肺炎链球菌肽链内切酶O(PepO)依赖MAPKs-NF-κB-PI3K/Akt信号激活肺泡上皮细胞分泌IL-6和CXCL

张红，张雪梅，尹一兵，王虹

《基因组学与应用生物学》

2015

肺炎链球菌糖代谢蛋白CcpA对荚膜多糖的调控作用

王丽滨，徐红梅，吴凯峰，郑玉强，王建敏，马峰，张雪梅，尹一兵，张群

《微生物学报》

2015

IL-27 enhances innate immunity of human pulmonary fibroblasts and epithelial cells through upregulation of TLR4 expression

Yu‐Feng Su, Hua Chuan Yao, Hong Wang, Fang Xu, Dagen Li, Dairong Li, Xuemei Zhang, Yibing Yin, Ju Cao

American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI

2015

DNA transducer-triggered signal switch for visual colorimetric bioanalysis

Wenhong Chen, Yurong Yan, Ye Zhang, Xuemei Zhang, Yibing Yin, Shijia Ding

Scientific Reports

DOI

2015

Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK)

Shuai Zhang, Jianmin Wang, Wenchun Xu, Yusi Liu, Wei Wang, Kaifeng Wu, Zhe Wang, Xuemei Zhang

Frontiers in Microbiology

DOI

2015

Progranulin is preferentially expressed in patients with psoriasis vulgaris and protects mice from psoriasis‐like skin inflammation

Kun Huang, Aijun Chen, Xuemei Zhang, Zhixin Song, Hongmei Xu, Ju Cao, Yibing Yin

Immunology

DOI

2015

Pneumococcal wall teichoic acid is required for the pathogenesis of Streptococcus pneumoniae in murine models

Hongmei Xu, Libin Wang, Jian Huang, Yanqing Zhang, Feng Ma, Jianmin Wang, Wenchun Xu, Xuemei Zhang, Yibing Yin, Kaifeng Wu

The Journal of Microbiology

DOI

2015

Compound 48/80 acts as a potent mucosal adjuvant for vaccination against Streptococcus pneumoniae infection in young mice

Lingbin Zeng, Yusi Liu, Hong Wang, Pu Liao, Zhixin Song, Song Gao, Yingying Wu, Xuemei Zhang, Yibing Yin, Wenchun Xu

Vaccine

DOI

2014

肺炎链球菌组氨酸激酶VicK的全长表达及其保守性分析

张帅，刘宇思，王虹，王哲，王维，张雪梅

《中国抗生素杂志》

2014

肺炎链球菌候选疫苗蛋白SPD0295的重组表达及免疫活性分析

闵迅，黄健，黄美容，黎美君，徐绣宇，钟文，张雪梅

《免疫学杂志》

2014

Interleukin 4 Deficiency Reverses Development of Secondary Pseudomonas aeruginosa Pneumonia During Sepsis-Associated Immunosuppression

Zhixin Song, J. Zhang, Xuemei Zhang, David Li, Haozhou Wang, X. Xu, Wencan Xu, Yi Bing Yin, Ju Cao

The Journal of Infectious Diseases

DOI

2014

Mucosal Immunization with the Live Attenuated Vaccine SPY1 Induces Humoral and Th2-Th17-Regulatory T Cell Cellular Immunity and Protects against Pneumococcal Infection

Xiuyu Xu, Hong Wang, Yusi Liu, Yiping Wang, Lingbing Zeng, Kaifeng Wu, Jianmin Wang, Feng Ma, Wenchun Xu, Yibing Yin, Xuemei Zhang

Infection and Immunity

DOI

2014

c‐Jun N‐terminal kinase and Akt signalling pathways regulating tumour necrosis factor‐α‐induced interleukin‐32 expression in human lung fibroblasts: implications in airway inflammation

Dagen Li, Dapeng Chen, Xuemei Zhang, Hong Wang, Zixin Song, Wenchun Xu, Yujuan He, Yibing Yin, Ju Cao

Immunology

DOI

2014

A Novel Protein, RafX, Is Important for Common Cell Wall Polysaccharide Biosynthesis in Streptococcus pneumoniae: Implications for Bacterial Virulence

Kaifeng Wu, Jian Huang, Yanqing Zhang, Wenchun Xu, Hongmei Xu, Libin Wang, Ju Cao, Xuemei Zhang, Yibing Yin

Journal of Bacteriology

DOI

2014

GHIP in Streptococcus pneumoniae is involved in antibacterial resistance and elicits a strong innate immune response through TLR 2 and JNK /p38 MAPK

Jie Dong, Jian Wang, Yujuan He, Chenwei Li, Aie Zhou, Jin Cui, Wenchun Xu, Liang Zhong, Yibing Yin, Xuemei Zhang, Hong Wang

FEBS Journal

DOI

2014

Mucosal and systemic immunization with a novel attenuated pneumococcal vaccine candidate confer serotype independent protection against Streptococcus pneumoniae in mice

Kaifeng Wu, Run Yao, Hong Wang, Dan Pang, Yusi Liu, Hongmei Xu, Shuai Zhang, Xuemei Zhang, Yibing Yin

Vaccine

DOI

2014

Serotype-independent protection against pneumococcal infections elicited by intranasal immunization with ethanol-killed pneumococcal strain, SPY1

Xiuyu Xu, Jiangping Meng, Yiping Wang, Jie Zheng, Kaifeng Wu, Xuemei Zhang, Yibing Yin, Qun Zhang

The Journal of Microbiology

DOI

2014

Interleukin 17A Promotes Pneumococcal Clearance by Recruiting Neutrophils and Inducing Apoptosis through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism in Acute Otitis Media

Wei Wang, Aie Zhou, Xuemei Zhang, Yun Xiang, Yifei Huang, Lei Wang, Shuai Zhang, Yusi Liu, Yibing Yin, Yujuan He

Infection and Immunity

DOI

2014

An efficient alternative marker for specific identification of Mycobacterium tuberculosis

Jianing Zhao, Yiwei Wang, Dairong Li, Jiawen Liu, Xuemei Zhang, Yujuan He, Hong Wang, Ju Cao, Yibing Yin, Wenchun Xu

World Journal of Microbiology and Biotechnology

DOI

2014

Mucosal Immunization with Recombinant Fusion Protein DnaJ-ΔA146Ply Enhances Cross-Protective Immunity against Streptococcus pneumoniae Infection in Mice via Interleukin 17A

Yusi Liu, Hong Wang, Shuai Zhang, Lingbin Zeng, Xiuyu Xu, Kaifeng Wu, Wei Wang, Nanlin Yin, Zhixin Song, Xuemei Zhang, Yibing Yin

Infection and Immunity

DOI

2013

热灭活肺炎链球菌D39X疫苗黏膜免疫小鼠可抵抗不同亚型肺炎链球菌感染

徐绣宇，王一平，蔡莺莺，刘宇思，王虹，胥文春，何於娟，尹一兵，张雪梅

《免疫学杂志》

2013

Activation of IL‐27 signalling promotes development of postinfluenza pneumococcal pneumonia

Ju Cao, Dongsheng Wang, Fang Xu, Yi Gong, Hong Wang, Zixin Song, Dageng Li, Hua Zhang, Dairong Li, Liping Zhang, Yun Xia, Huajian Xu, Xaiofei Lai, Shihui Lin, Xuemei Zhang, Guosheng Ren, Yubing Dai, Yibing Yin

EMBO Molecular Medicine

DOI

2013

Screening and identification of ClpE interaction proteins in Streptococcus pneumoniae by a bacterial two-hybrid system and co-immunoprecipitation

Wenjuan Yan, Yingying Cai, Qun Zhang, Yusi Liu, Wenchun Xu, Yibing Yin, Yujuan He, Hong Wang, Xuemei Zhang

The Journal of Microbiology

DOI

2013

Screening and Identification of DnaJ Interaction Proteins in Streptococcus pneumoniae

Yingying Cai, Wenjuan Yan, Wenchun Xu, Yibing Yin, Yujuan He, Hong Wang, Xuemei Zhang

Current Microbiology

DOI

2013

Pneumococcal ClpP modulates the maturation and activation of human dendritic cells: implications for pneumococcal infections

Ju Cao, Yi Gong, Shan‐Shan Dong, Liping Zhang, Xaiofei Lai, Xuemei Zhang, Yibing Yin

Journal of Leukocyte Biology

DOI

2013

Synergy of IL-27 and TNF-α in Regulating CXCL10 Expression in Lung Fibroblasts

Shan‐Shan Dong, Xuemei Zhang, Yujuan He, Fang Xu, Dairong Li, Wenchun Xu, Hong Wang, Yibing Yin, Ju Cao

American Journal of Respiratory Cell and Molecular Biology

DOI

2012

SP0454, a putative threonine dehydratase, is required for pneumococcal virulence in mice

Wenjuan Yan, Hong Wang, Wenchun Xu, Kaifeng Wu, Run Yao, Xiuyu Xu, Jie Dong, YanQing Zhang, Wen Zhong, Xuemei Zhang

The Journal of Microbiology

DOI

2012

Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A

Xun Min, Xuemei Zhang, Hong Wang, Yi Gong, Meijuan Li, Wenchun Xu, Yibing Yin, Ju Cao

Vaccine

DOI

2011

肺炎链球菌溶血素ΔA146Ply黏膜免疫的保护效果

姚润，崔亚利，袁军，王虹，龚艺，尹一兵，张雪梅

《中国生物制品学杂志》

2011

肺炎链球菌溶血素的体外表达及活性鉴定

贺潇，袁军，王虹，李忱炜，姜慧，董杰，崔瑾，董姗姗，周爱娥，张雪梅，胥文春，尹一兵，何於娟

《陆军军医大学学报》

2011

肺炎链球菌溶血素诱导THP-1细胞凋亡涉及MAPK1/3信号途径

姜慧，贺潇，袁军，王虹，李忱炜，董杰，崔瑾，董姗姗，周爱娥，张雪梅，胥文春，尹一兵，何於娟

《陆军军医大学学报》

2011

The Role of ClpP in Protein Expression of Streptococcus pneumoniae

Qun Zhang, Yuanshuai Huang, Hong Wang, Wenchun Xu, Lan Liu, Yibing Yin, Xuemei Zhang

Current Microbiology

DOI

2011

Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae

Yali Cui, Xuemei Zhang, Yi Gong, Siqiang Niu, Nanlin Yin, Run Yao, Wenchun Xu, Dairong Li, Hong Wang, Yujuan He, Ju Cao, Yibing Yin

Vaccine

DOI

2011

Protective Effect of Mucosal Immunization with ΔA146Ply against Streptococcus pneumoniae

Xuemei Zhang

Zhongguo shengwuzhipinxue zazhi

2011

Construction of Streptococcus mutans LuxS gene deletion mutants by long flanking homology polymerase chain reaction

Xuemei Zhang

Zhongguo weishengtaixue zazhi

2011

The effect of Streptococcus mutans biofilm formation after LuxS was knocked out

Xuemei Zhang

Zhongguo weishengtaixue zazhi

2010

假想的脂蛋白连接酶对肺炎链球菌毒力的影响

杨晓亮，尹楠林，庞丹，吴凯峰，尹一兵，张雪梅

《微生物学报》

2010

comE基因缺陷影响肺炎链球菌体内诱导基因的表达

刘鑫，尹楠林，张雪梅，杨晓亮，庞丹，王虹，尹一兵，胥文春

《微生物学报》

2010

运用酶切自连法分析鉴定肺炎链球菌体内诱导基因

庞丹，王虹，尹楠林，杨晓亮，胥文春，尹一兵，张雪梅

《生物技术通报》

2010

Immunization with a ZmpB-Based Protein Vaccine Could Protect against Pneumococcal Diseases in Mice

Yi Gong, Wenchun Xu, Yali Cui, Xuemei Zhang, Run Yao, Dairong Li, Hong Wang, Yujuan He, Ju Cao, Yibing Yin

Infection and Immunity

DOI

2010

Pneumococcal proteins PspA and PspC induce CXCL8 production in human neutrophils: implications in pneumococcal infections

Ju Cao, Yi Gong, Yibing Yin, Lanlan Wang, Binwu Ying, Tingmei Chen, Xuemei Zhang

Microbes and Infection

DOI

2010

In vivo characterization of Streptococcus pneumoniae genes involved in the pathogenesis of meningitis by differential fluorescence induction

Wenchun Xu, Xuemei Zhang, Jiangping Meng, Kaifeng Wu, Hong Wang, Qing Zhao, Nan Li, Fang Cui, Xing-Hua Zhu, Ju Cao, Cao-Zhong Shu, You-Lan Shan, Yibing Yin

Saudi Medical Journal

DOI

2010

Molecular mechanisms of the secretion of cytokines and chemokines from human monocytes activated by pneumococcal surface protein A (PspA): Roles of mitogen-activated protein kinases and NF-kappaB

Ju Cao, Tingmei Chen, Yi Gong, Bingwu Ying, Dairong Li, Wenchun Xu, Xuemei Zhang, Lanlan Wang, Yibing Yin

Microbial Pathogenesis

DOI

2010

Preliminary analysis of growth variance of Streptococcus mutans and its mutants.

Yueheng Li, Zhi Zhou, Chen Jiao, Rui Li, Yin Yibing, Xuemei Zhang

Zhongguo weishengtaixue zazhi

2009

操纵子comCDE调控肺炎链球菌转化的分子机制研究

袁泰先，朱兴华，吴凯峰，尹楠林，胥文春，王虹，尹一兵，张雪梅

《重庆医科大学学报》

2009

clpE缺陷对肺炎球菌蛋白表达的影响

张群，尹楠林，张雪梅，王虹，刘鑫，崔亚丽，尹一兵，胥文春

《南方医科大学学报》

2009

肺炎链球菌双组份系统中的组氨酸激酶(YycG)的同源模建与分析

李南，王非，胥文春，王虹，罗小民，朱维良，尹一兵，张雪梅

《生物工程学报》

2009

clpE基因缺失对肺炎链球菌毒力的影响

张群，尹楠林，胥文春，王虹，庞丹，杨晓亮，尹一兵，张雪梅

《微生物学报》

2009

Immunization with a Combination of Three Pneumococcal Proteins Confers Additive and Broad Protection against Streptococcus pneumoniae Infections in Mice

Kaifeng Wu, Xuemei Zhang, Jing Shi, Nan Li, Dairong Li, Miao Luo, Ju Cao, Nanlin Yin, Hong Wang, Wenchun Xu, Yujuan He, Yibing Yin

Infection and Immunity

DOI

2009

Contribution of ClpE to virulence ofStreptococcus pneumoniae

Qun Zhang, Songxiao Xu, Hong Wang, Wenchun Xu, Xuemei Zhang, Kaifeng Wu, Lan Liu, Yibing Yin

Canadian Journal of Microbiology

DOI

2009

Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

Nan Li, Fei Wang, Siqiang Niu, Ju Cao, Kaifeng Wu, Youqiang Li, Nanlin Yin, Xuemei Zhang, Weiliang Zhu, Yibing Yin

BMC Microbiology

DOI

2009

CD4+ T lymphocytes mediated protection against invasive pneumococcal infection induced by mucosal immunization with ClpP and CbpA

Ju Cao, Yi Gong, Dairong Li, Nanlin Yin, Tingmei Chen, Wenchun Xu, Xuemei Zhang, Yibing Yin

Vaccine

DOI

2008

鼻腔滴注法建立小鼠肺炎链球菌性脑膜炎模型

胥文春，单幼兰，李南，赵清，张雪梅，刘明芳，尹一兵

《中国病原生物学杂志》

2008

Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice

Ju Cao, Tingmei Chen, Dairong Li, Chun Kwok Wong, Dapeng Chen, Wenchun Xu, Xuemei Zhang, Christopher Wai Kei Lam, Yibing Yin

Microbes and Infection

DOI

2008

Identification of Streptococcus pneumoniae genes specifically induced in mouse lung tissues

Jiang-Ping Meng, Yi-Bing Yin, Xuemei Zhang, Yuanshuai Huang, Kai Lan, Fang Cui, Songxiao Xu

Canadian Journal of Microbiology

DOI

2007

Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP

Ju Cao, Dapeng Chen, Wenchun Xu, Tingmei Chen, Songxiao Xu, Jingyong Luo, Qing Zhao, Beizhong Liu, Dongsheng Wang, Xuemei Zhang, You-Lan Shan, Yibing Yin

Vaccine

DOI

2006

肺炎链球菌体内诱导基因的筛选及初步鉴定

孟江萍，尹一兵，张雪梅，黄远帅，蓝锴

《微生物学报》

2006

肺炎链球菌转化模型的建立与优化

孟江萍，尹一兵，张雪梅，蓝锴，黄远帅，涂植光

《微生物学杂志》

2005

肺炎链球菌的转化缺陷导致细菌毒力减弱

张雪梅，尹一兵，朱旦，陈保德，罗进勇，邓一平，刘明芳，陈淑慧，孟江萍，徐邦牢，康格非

《中华微生物学和免疫学杂志》

2005

The effect of transformation on the virulence of Streptococcus pneumoniae.

Xuemei Zhang, Yi-Bing Yin, Dan Zhu, Bao-De Chen, Luo Jin-yong, Yiping Deng, Mingfang Liu, Shu-Hui Chen, Jiang-Ping Meng, Kai Lan, Yuanshuai Huang, Ge-Fei Kang

PubMed

2004

肺炎链球菌毒力基因体内荧光报告系统的构建

陈保德，尹一兵，张雪梅

《微生物学通报》

2004

肺炎链球菌磷壁酸胆碱成分介导细菌的侵袭

尹一兵，周东耀，张雪梅，孟江萍，康格非

《微生物学报》

2003

肺炎链球菌感受态缺陷影响细菌对β-内酰胺类抗生素的敏感性

张雪梅，尹一兵，陈茶，陈保德，孟江萍，康格非

《中华微生物学和免疫学杂志》

2003

肺炎链球菌在体外触发人肺Ⅱ型上皮细胞F-actin细胞骨架重排

尹一兵，徐邦牢，张雪梅，罗进勇

《中华微生物学和免疫学杂志》

2003

肺炎链球菌转化对细菌毒力和耐药性影响的研究

张雪梅

《重庆医科大学》

2003

肺炎链球菌感受态的形成影响毒力因子mRNA的表达

王嬿，尹一兵，猪川嗣朗，罗进勇，张雪梅

《中华微生物学和免疫学杂志》

2002

肺炎链球菌自然转化机制的研究进展

张雪梅

《国际检验医学杂志》

会议论文

2012

一种新的肺炎链球菌毒力因子溶菌酶样蛋白有利于细菌抵抗中性粒细胞杀伤并以MAPKp38和JNK依赖的方式刺激鼠巨噬细胞分泌细胞因子

董杰，王虹，周爱娥，张雪梅，尹一兵

《中华医学会第七次全国中青年检验医学学术会议论文汇编》

研究方向

细菌毒力因子调控分子机制研究

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