付书林｜武汉轻工大学｜学者主页

2026

Mechanisms of AFB1-induced neurotoxicity and protective effect of baicalin via inflammatory and antioxidant pathways in ducklings

Pu Guo, Xin-Lan Ke, Hualin Zhou, Jie Zhang, Qi-Rong Lu, Yu Liu, Chun Ye, Shulin Fu, Yinsheng Qiu, Zhongyuan Wu, Jiang-lin Xiong

Poultry Science

DOI

2026

Glaesserella parasuis Infection Modulates the Transcriptome of Porcine Peritoneal Mesothelial Primary Cells: Implications for Understanding Peritoneal Invasion Mechanisms

Pu Guo, Jialong Fan, Yang-Fan Dong, Jiacheng Zhang, Qi-Rong Lu, Chun Ye, Shulin Fu, Zhongyuan Wu, Yu Liu, Yinsheng Qiu

Biology

DOI

2026

Integrated Characterization of ceRNA (circRNA/lncRNA/miRNA/mRNA) Regulatory Networks in a Glaesserella parasuis–Induced Mouse Meningitis Model

Lin-Rong Yang, Ying-Yi Wu, Zhi-Yi Yan, Yan Fei, Shulin Fu, Ling Guo, Z. Chao

Animals

DOI

2026

IL-17 signaling pathway in monocytes drives the persistent inflammatory cytokine storm caused by Glaesserella parasuis infection in pigs.

Peiyi Wang, Aihua Wu, Jianing Niu, Wei Liu, Shulin Fu, Yan-Yan Zhang, Bing-Bing Zong, Yinsheng Qiu

Veterinary Microbiology

DOI

2025

黄芩苷通过抗炎机制降低猪源肠外致病性大肠杆菌感染损伤

刘微，任明星，王培懿，肖涌，吴爱华，张焱焱，付书林，邱银生，宗冰冰

《微生物学报》

DOI

2025

Baicalin Alleviates Piglet Immunosuppression Induced by Glaesserella parasuis via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy

Shulin Fu, Ronghui Luo, Jingyang Li, Yunjian Fu, Qiaoli Dong, Siyu Liu, Ya-Min Sun, Ling Guo, Jin Hu, Yinsheng Qiu

Biomolecules

DOI

2025

Baicalin-aluminum complexes inhibit growth and suppress virulence of enterotoxigenic Escherichia coli in vitro.

Chun Ye, Xingyue Li, Yun-Qing Liu, Yuqian Chen, Ming Zhao, Ronghua Yin, Qi-Rong Lu, Jin Liu, Yu Liu, Shulin Fu, Yinsheng Qiu

Toxicon

DOI

2025

Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets

Shulin Fu, Qiaoli Dong, Yunjian Fu, Ronghui Luo, Jingyang Li, Ya-Min Sun, Siyu Liu, Yinsheng Qiu, Ling Guo, Jin Hu

Biomolecules

DOI

2025

The Regulatory Role of EvfG Through Coordinated Control of Flagellar Biosynthesis and Energy Metabolism in Porcine Extraintestinal Pathogenic Escherichia coli (ExPEC)

Bing-Bing Zong, Peiyi Wang, Wei Liu, Aihua Wu, Yong Xiao, Shulin Fu, Yinsheng Qiu, Yanyan Zhang, Wen-Tong Liu

Biology

DOI

2025

Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis

Qi-Rong Lu, Xuwen Liu, Junke Tian, Pu Guo, Chun Ye, Shulin Fu, Yu Liu, Yinsheng Qiu

Animals

DOI

2025

Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Ling Guo, Ya-Qiong Yang, Lin-Rong Yang, Peiyan Sun, Jing He, Shulin Fu, Chun Ye, Bing-Bing Zong, Yinsheng Qiu

BMC Veterinary Research

DOI

2025

Network Pharmacology to Unveil the Mechanism of Berberine in the Treatment of Streptococcus suis Meningitis in Humans and Pigs

Pu Guo, Yunda Xue, Dan Zhang, Qi-Rong Lu, Yu Liu, Jiang-lin Xiong, Chun Ye, Shulin Fu, Zhongyuan Wu, Xu Wang, Yinsheng Qiu

Toxics

DOI

2025

Protective Effects of Luteolin on Glaesserella parasuis-Induced Injury: An In Vitro Study with Porcine Vascular Endothelial Cells

Pu Guo, Xuwen Liu, Xiaoyi Li, Awais Ihsan, Zhongyuan Wu, Shulin Fu, Chun Ye, Yinsheng Qiu, Xu Wang, Qi-Rong Lu, Yu Liu

Antibiotics

DOI

2025

Baicalin Mitigates Pasteurella multocida-Induced Pulmonary and Vascular Injury via NLRP3/COX-2 Inhibition in Mice

Dan Zhang, Cheng-Zhu Zhao, Yunda Xue, Qi-Rong Lu, Yu Liu, Jiang-lin Xiong, Chun Ye, Shulin Fu, Zhongyuan Wu, Yinsheng Qiu, Pu Guo

Animals

DOI

2025

Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge

Jingyang Li, Ronghui Luo, Yunjian Fu, Siyu Liu, Qiaoli Dong, Ya-Min Sun, Xinyue Tian, Yi Zhu, Peiyi Wang, Ling Guo, Qi-Rong Lu, Chun Ye, Shulin Fu, Yinsheng Qiu

Biomolecules

DOI

2025

Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice

Qi-Rong Lu, Lu-Yao Wang, Xueping Jiang, Wantong Han, Pu Guo, Yu Liu, Shulin Fu, Jiang-lin Xiong, Zhongyuan Wu, Yinsheng Qiu

Frontiers in Veterinary Science

DOI

2024

4个基因在副猪嗜血杆菌感染仔猪脑组织中DNA甲基化与mRNA表达联合验证

杨雅琼，程鸿星，梁明霞，刘玉兰，付书林，张晶，陈洪波，任红艳，郭玲，晁哲

《中国畜牧兽医》

2024

Using network pharmacology and molecular docking to uncover the mechanism by which quercetin alleviates deoxynivalenol-induced porcine intestinal injury.

Pu Guo, Xue-Ming Li, Yunda Xue, Qi-Rong Lu, Yu Liu, Jiang-lin Xiong, Zhongyuan Wu, Shulin Fu, Chun Ye, Xu Wang, Yinsheng Qiu

Toxicon

DOI

2024

Genomic and transcriptomics analysis reveal putative secreted proteins expressed of Pasteurella multocida during 18β-glycyrrhetinic acid treatment

Zhongyuan Wu, Yuhan Zhang, Lu-Yao Wang, Meng Mei, Yinsheng Qiu, Yu Liu, Shulin Fu, Jiang-lin Xiong, Qi-Rong Lu, Pu Guo

Frontiers in Veterinary Science

DOI

2024

PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

Jingyang Li, Siyu Liu, Qiaoli Dong, Yunjian Fu, Ya-Min Sun, Ronghui Luo, Xinyue Tian, Ling Guo, Wei Liu, Yinsheng Qiu, Qi-Rong Lu, Chun Ye, Bing-Bing Zong, Shulin Fu

BMC Veterinary Research

DOI

2024

Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model

Shulin Fu, Siyu Liu, Jingyang Li, Qiaoli Dong, Yunjian Fu, Ronghui Luo, Ya-Min Sun, Xinyue Tian, Wei Liu, Bing-Bing Zong, Chun Ye, Qi-Rong Lu, Yinsheng Qiu, Ling Guo

Veterinary Research

DOI

2024

LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens–induced necrotic enteritis of laying hens

Qiaoli Dong, Ya-Min Sun, Jingyang Li, Xinyue Tian, Siyu Liu, Yunjian Fu, Ronghui Luo, Ling Guo, Bing-Bing Zong, Qi-Rong Lu, Chun Ye, Shulin Fu, Yinsheng Qiu

Poultry Science

DOI

2024

Baicalin-aluminum complex on the regulation of IPEC-1 infected with enterotoxigenic Escherichia coli

Chun Ye, Yuqian Chen, Ruixue Yu, Ming Zhao, Ronghua Yin, Yinsheng Qiu, Shulin Fu, Yu Liu, Zhongyuan Wu

Heliyon

DOI

2024

Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways

Xinyue Tian, Jingyang Li, Siyu Liu, Qiaoli Dong, Yunjian Fu, Ronghui Luo, Ya-Min Sun, Ling Guo, Qi-Rong Lu, Chun Ye, Jin Liu, Shulin Fu, Yinsheng Qiu

Heliyon

DOI

2024

Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways

Shulin Fu, Jingyang Li, Jiarui You, Siyu Liu, Qiaoli Dong, Yunjian Fu, Ronghui Luo, Ya-Min Sun, Xinyue Tian, Wei Liu, Jingyi Zhang, Yu Ding, Yitian Zhang, Wutao Wang, Ling Guo, Yinsheng Qiu

Veterinary Research

DOI

2024

Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.

Qi-Rong Lu, Nan Wang, Defeng Wen, Pu Guo, Yu Liu, Shulin Fu, Chun Ye, Zhongyuan Wu, Yinsheng Qiu

Toxicon

DOI

2024

Baicalin Weakens the Virulence of Porcine Extraintestinal Pathogenic Escherichia coli by Inhibiting the LuxS/AI-2 Quorum-Sensing System

Bing-Bing Zong, Yong Xiao, Peiyi Wang, Wei Liu, Mingxing Ren, Chang Li, Shulin Fu, Yanyan Zhang, Yinsheng Qiu

Biomolecules

DOI

2024

Quercetin Protects Blood–Brain Barrier Integrity via the PI3K/Akt/Erk Signaling Pathway in a Mouse Model of Meningitis Induced by Glaesserella parasuis

Peiyan Sun, Ya-Qiong Yang, Lin-Rong Yang, Y. Qian, M. Liang, Hong-Bo Chen, Jing Zhang, Yinsheng Qiu, Ling Guo, Shulin Fu

Biomolecules

DOI

2024

Correction: Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/ Akt/mTOR and RAS/MEK/ERK signalling pathways

Shulin Fu, Jingyang Li, Jiarui You, Siyu Liu, Qiaoli Dong, Yunjian Fu, Ronghui Luo, Ya-Min Sun, Xinyue Tian, Wei Liu, Jingyi Zhang, Yu Ding, Yitian Zhang, Wutao Wang, Ling Guo, Yinsheng Qiu

Veterinary Research

DOI

2023

黄芩苷抑制Panx-1和P2X7的激活减轻副猪嗜血杆菌病血管内皮细胞损伤

周灵露，付书林，袁昱珍，邱银生

《中南农业科技》

2023

副猪嗜血杆菌感染猪脑组织中候选基因表达水平与DNA甲基化联合分析

程鸿星，孙培燕，杨雅琼，邱银生，陈洪波，张晶，付书林，郭玲

《黑龙江畜牧兽医》

2023

黄芩苷对猪源肠外致病性大肠杆菌的体内保护作用

任明星，肖涌，付书林，宗冰冰，邱银生

《湖北农业科学》

2023

Integrated Analysis of Long Non-Coding RNA Expression Profiles in Glaesserella parasuis-Induced Meningitis: New Insight into Pathogenesis

Peiyan Sun, Ya-Qiong Yang, Hongxing Cheng, Shulin Fu, Yu-Lan Liu, Yinsheng Qiu, Hong-Bo Chen, Jing Zhang, Hua-Ping Zhou, Liang-Yu Shi, H. Ren, Z. Chao, Ling Guo

Microbiology Research

DOI

2023

Baicalin Attenuated PANX-1/P2X7 Axis, P2Y6, and NLRP3/Caspase-1 Signaling Pathways in Peritonitis Induced by Glaesserella parasuis

Shulin Fu, Xinyue Tian, Jingyang Li, Yuzhen Yuan, Xiaoyi Li, Mingxing Ren, Ling Guo, Chun Ye, Bing-Bing Zong, Yu Liu, Qirong Lu, Yinsheng Qiu

Microbiology Research

DOI

2023

Metagenomic Sequencing Analysis of the Effects of Acetylcysteine on the Pig Gut Microbiome

Shulin Fu, Xinyue Tian, Jingyang Li, Yuzhen Yuan, Jing He, Chun Peng, Ling Guo, Chun Ye, Yu Liu, Bing-Bing Zong, Yinsheng Qiu

Microbiology Research

DOI

2023

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bing-Bing Zong

Heliyon

DOI

2023

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells

Qirong Lu, Wantong Han, Defeng Wen, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Chun Ye, Xu Wang, Yinsheng Qiu

Infection and Drug Resistance

DOI

2023

Baicalin-aluminum alleviates necrotic enteritis in broiler chickens by inhibiting virulence factors expression of Clostridium perfringens

Jin Liu, Shuangqi Wu, Hong-Hao Zhao, Chun Ye, Shulin Fu, Yu Liu, Ting Liu, Yinsheng Qiu

Frontiers in Cellular and Infection Microbiology

DOI

2023

Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury.

Defeng Wen, Wantong Han, Quan Chen, Guan-Hui Qi, M. Gao, Pu Guo, Yu Liu, Zhongyuan Wu, Shulin Fu, Qi-Rong Lu, Yinsheng Qiu

Toxicon

DOI

2023

Effects of Baicalin-Aluminum on the Virulence-Associated Traits and Virulence Genes Expression of Clostridium Perfringens

Jin Liu, Shuangqi Wu, Hong-Hao Zhao, Chun Ye, Shulin Fu, Yu Liu, Yinsheng Qiu

Social Science Research Network

DOI

2023

Baicalin Weakens the Porcine ExPEC-Induced Inflammatory Response in 3D4/21 Cells by Inhibiting the Expression of NF-κB/MAPK Signaling Pathways and Reducing NLRP3 Inflammasome Activation

Bing-Bing Zong, Yong Xiao, Mingxing Ren, Peiyi Wang, Shulin Fu, Yinsheng Qiu

Microorganisms

DOI

2022

Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations

Shulin Fu, Yuzhen Yuan, Xinyue Tian, Linglu Zhou, Ling Guo, Dan Zhang, Jing He, Chun Peng, Yinsheng Qiu, Chun Ye, Yu Liu, Bing-Bing Zong

Veterinary Sciences

DOI

2022

Methylome and Transcriptome-Based Integration Analysis Identified Molecular Signatures Associated With Meningitis Induced by Glaesserella parasuis

Ling Guo, Hongxing Cheng, Shulin Fu, J. Liu, Yun-Fei Zhang, Yinsheng Qiu, Hongbo Chen

Frontiers in Immunology

DOI

2022

Baicalin Alleviate Apoptosis via PKC-MAPK Pathway in Porcine Peritoneal Mesothelial Cells Induced by Glaesserella parasuis

Qirong Lu, Lang Zhou, Zi-yi Wang, Xiao-Min Li, Liang Wen Ding, Yinsheng Qiu, Pu Guo, Chun Ye, Shulin Fu, Zhongyuan Wu, Yu Liu

Molecules

DOI

2021

黄芩苷对仔猪感染副猪嗜血杆菌后血细胞分类计数和血液生化指标的影响

张佳诚，刘军，付书林，刘宇，邱银生

《湖北畜牧兽医》

DOI

2021

Metagenomic Sequencing Analysis of the Effects of Colistin Sulfate on the Pig Gut Microbiome

Ling Guo, Dan Zhang, Shulin Fu, Jiacheng Zhang, Xiaofang Zhang, Jing He, C. Peng, Yun-Fei Zhang, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Chien-An A. Hu

Frontiers in Veterinary Science

DOI

2021

Protective Effects of Baicalin on Peritoneal Tight Junctions in Piglets Challenged with Glaesserella parasuis

Jiacheng Zhang, Zhaoran Zhang, Jianfeng Xu, Chun Ye, Shulin Fu, Chien-An A. Hu, Yinsheng Qiu, Yu Liu

Molecules

DOI

2021

Baicalin Protects Vascular Tight Junctions in Piglets During Glaesserella parasuis Infection

Yu Liu, Xiaoyi Li, Zhao-Ran Zhang, Jiacheng Zhang, Jianfeng Xu, Yinsheng Qiu, Chun Ye, Shulin Fu, Zhongyuan Wu, Chien-An A. Hu

Frontiers in Veterinary Science

DOI

2021

Baicalin-Aluminum Modulates the Broiler Gut Microbiome

Ling Guo, Jing He, Jiacheng Zhang, Xiaofang Zhang, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Shulin Fu, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Chien-An A. Hu

DNA and Cell Biology

DOI

2021

Determination of Colistin in Contents Derived from Gastrointestinal Tract of Feeding Treated Piglet and Broiler

Chun Peng, Sanling Zuo, Yinsheng Qiu, Shulin Fu, Lijuan Peng

Antibiotics

DOI

2021

Effect of Baicalin on Transcriptome Changes in Piglet Vascular Endothelial Cells Induced by a Combination of Glaesserella parasuis and Lipopolysaccharide

Shulin Fu, Qingyang Meng, Dan Zhang, Sanling Zuo, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu-Lan Liu, Chien-An A. Hu

DNA and Cell Biology

DOI

2020

黄芩苷对脂多糖诱导后仔猪生理机能的影响

庄锋，赵文华，付书林，刘宇，邱银生

《黑龙江畜牧兽医》

DOI

2020

黄芩苷对脂多糖诱导后仔猪血清和组织中炎性细胞因子表达的影响

熊春红，赵文华，刘宇，付书林，邱银生

《黑龙江畜牧兽医》

DOI

2020

The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis

Shulin Fu, Jun Liu, Jianfeng Xu, Sanling Zuo, Yun-Fei Zhang, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An A. Hu

Molecular and Cellular Biochemistry

DOI

2020

The effects of baicalin on piglets challenged with Glaesserella parasuis

Shulin Fu, R. Yin, Sanling Zuo, Jun Liu, Yun-Fei Zhang, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An A. Hu

Veterinary Research

DOI

2020

The Effect of Baicalin on the Expression Profiles of Long Non-Coding RNAs and mRNAs in Porcine Aortic Vascular Endothelial Cells Infected with Haemophilus parasuis

Ling Guo, Jun Liu, Yun-Fei Zhang, Shulin Fu, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An A. Hu

DNA and Cell Biology

DOI

2019

黄芩苷对副猪嗜血杆菌诱导后猪血管内皮细胞黏附分子表达的影响

徐健峰，郭靖，刘华山，付书林，邱银生

《武汉轻工大学学报》

2019

黄芩苷对脂多糖诱导后仔猪的血管紧密连接蛋白表达量和MLCK-MLC的影响

赵文华，庄锋，熊春红，刘宇，付书林，邱银生

《中国畜牧兽医》

DOI

2019

Effects of Baicalin on piglet monocytes involving PKC–MAPK signaling pathways induced by Haemophilus parasuis

Chun Ye, Ruizhi Li, Lei Xu, Yinsheng Qiu, Shulin Fu, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An A. Hu

BMC Veterinary Research

DOI

2019

Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets.

Yu Liu, Wenhua Zhao, Jianfeng Xu, Xiaolin Yu, Chun Ye, Shulin Fu, Yinsheng Qiu

Journal of Veterinary Pharmacology and Therapeutics

DOI

2019

Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion

Shulin Fu, Wenhua Zhao, Chun-Hong Xiong, Ling Guo, Jing Guo, Yinsheng Qiu, Chien-An A. Hu, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou

Innate Immunity

DOI

2019

Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets

Shulin Fu, F. Zhuang, Ling Guo, Yinsheng Qiu, J. Xiong, Chun Ye, Yu Liu, Zhongyuan Wu, Yongqing Hou, Chien-An A. Hu

International Journal of Molecular Sciences

DOI

2019

Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis

Ling Guo, Linna Li, Yang Zhang, Shulin Fu, Jing Zhang, Xiu-Ying Wang, Hui-Ling Zhu, M. Qiao, Ling-Ying Wu, Yu-Lan Liu

Innate Immunity

DOI

2018

Baicalin modulates NF-κB and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glässer’s disease

Shulin Fu, Huashan Liu, Lei Xu, Yinsheng Qiu, Yu Liu, Zhongyuan Wu, Chun Ye, Yongqing Hou, Chien-An A. Hu

Scientific Reports

DOI

2018

Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation

Shulin Fu, Huashan Liu, Xiao Chen, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Ling Guo, Yongqing Hou, Chien-An A. Hu

International Journal of Molecular Sciences

DOI

2018

Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis

Ling Guo, Jing Guo, Huashan Liu, Jing Zhang, Xiabing Chen, Yinsheng Qiu, Shulin Fu

Journal of Veterinary Medical Science

DOI

2018

Transcriptional Profiling of Host Cell Responses to Virulent Haemophilus parasuis: New Insights into Pathogenesis

Shulin Fu, Jing Guo, Ruizhi Li, Yinsheng Qiu, Chun Ye, Yu Liu, Zhongyuan Wu, Ling Guo, Yongqing Hou, Chien-An A. Hu

International Journal of Molecular Sciences

DOI

2017

Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model.

Ling Guo, Lei Xu, Tao Wu, Shulin Fu, Yinsheng Qiu, Chien-An A. Hu, Xinglong Ren, Rongrong Liu, Mengdie Ye

Canadian Journal of Microbiology (print)

DOI

2017

Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation

Bing Yang, Zhi-Xin Lei, Yi-Shuang Zhao, S. Ahmed, Chun-Qun Wang, Shi-Shuo Zhang, Shulin Fu, Ji-Yue Cao, Yinsheng Qiu

Frontiers in Microbiology

DOI

2017

Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis

Zhi-Xin Lei, Shulin Fu, Bing Yang, Qian-Ying Liu, S. Ahmed, Lei Xu, Jin-Cheng Xiong, Ji-Yue Cao, Yinsheng Qiu

Scientific Reports

DOI

2016

Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection

Shulin Fu, Lei Xu, Sali Li, Yinsheng Qiu, Yu Liu, Zhongyuan Wu, Chun Ye, Yongqing Hou, Chien-An A. Hu

Veterinary Research

DOI

2016

The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Jie Chen, Wen-Tao Li, Er-Guang Jin, Qi-Gai He, Weidong Yan, Han-Chun Yang, Shiyu Gong, Yi Guo, Shulin Fu, Xiabing Chen, Sheng-Qiang Ye, Yun-Guo Qian

Research in Veterinary Science

DOI

2015

副猪嗜血杆菌反应调节因子CpxR自杀性质粒的构建

付书林，陈夏冰，何斌，邵志勇，杨文海，刘武，金尔光，童伟文，陶弼菲，张四化，陈洁

《湖北农业科学》

2015

牛蒡苷元对疫苗免疫猪抗体和T细胞亚群的影响

陈夏冰，付书林，何斌，杨文海，鲍伯胜，童新红，刘武，童伟文，陶弼菲，陈洁

《中国兽医杂志》

2015

Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence.

Jin-Lin Liu, Lin-Lin Hu, Zhuo-Fei Xu, Chen Tan, F. Yuan, Shulin Fu, Hui Cheng, Huan-Chun Chen, Wei-Cheng Bei

Veterinary Microbiology

DOI

2014

The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2.

Juan Xu, Shulin Fu, Man-Li Liu, Qiaoxia Xu, Wei-Cheng Bei, Huan-Chun Chen, Chen Tan

Microbiology Research

DOI

2013

Immunogenicity and protective efficacy of recombinant Haemophilus parasuis SH0165 putative outer membrane proteins.

Shulin Fu, Min-Min Zhang, Juan Xu, Jiwen Ou, Yan Wang, Hua-Zhen Liu, Jin-Lin Liu, Huan-Chun Chen, Wei-Cheng Bei

Vaccine

DOI

2012

The Live Attenuated Actinobacillus pleuropneumoniae Triple-Deletion Mutant ΔapxIC ΔapxIIC ΔapxIV-ORF1 Strain, SLW05, Immunizes Pigs against Lethal Challenge with Haemophilus parasuis

Shulin Fu, Jiwen Ou, Min-Min Zhang, Juan Xu, Hua-Zhen Liu, Jin-Lin Liu, F. Yuan, Huan-Chun Chen, Wei-Cheng Bei

Clinical and Vaccine Immunology

DOI

2012

Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice.

Shulin Fu, Min-Min Zhang, Jiwen Ou, Hua-Zhen Liu, Chen Tan, Jin-Lin Liu, Huan-Chun Chen, Wei-Cheng Bei

Vaccine

DOI

2012

Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate dehydrogenase, of Haemophilus parasuis.

Shulin Fu, F. Yuan, Min-Min Zhang, Chen Tan, Huan-Chun Chen, Wei-Cheng Bei

Research in Veterinary Science

DOI

2012

Evaluation of recombinant proteins of Haemophilus parasuis strain SH0165 as vaccine candidates in a mouse model.

F. Yuan, Shulin Fu, Jin Hu, Jinquan Li, Hai-Tao Chang, Lin-Lin Hu, Huan-Chun Chen, Yong-Xiang Tian, Wei-Cheng Bei

Research in Veterinary Science

DOI

2011

The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2.

Jinquan Li, Chen Tan, Yang Zhou, Shulin Fu, Lin-Lin Hu, Jin Hu, Huan-Chun Chen, Wei-Cheng Bei

Veterinary Microbiology

DOI

2011

Influences of ORF1 on the Virulence and Immunogenicity of Actinobacillus pleuropneumoniae

F. Yuan, Jin-Lin Liu, Yi Guo, Chen Tan, Shulin Fu, Jin Zhao, Huan-Chun Chen, Wei-Cheng Bei

Current Microbiology

DOI

2009

Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine.

Chen Tan, Man-Li Liu, Jin-Lin Liu, F. Yuan, Shulin Fu, Yuan Liu, M. Jin, Wei-Cheng Bei, Huan-Chun Chen

FEMS Microbiology Letters

DOI

2009

In vivo induced RTX toxin ApxIVA is essential for the full virulence of Actinobacillus pleuropneumoniae.

Jin-Lin Liu, Xia Chen, Chen Tan, Yi Guo, Yan Chen, Shulin Fu, Wei-Cheng Bei, Huan-Chun Chen

Veterinary Microbiology

DOI

2008

Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2.

Chen Tan, Shulin Fu, Man-Li Liu, M. Jin, Jin-Lin Liu, Wei-Cheng Bei, Huan-Chun Chen

Veterinary Microbiology

DOI

精选作品

期刊论文

Mechanisms of AFB1-induced neurotoxicity and protective effect of baicalin via inflammatory and antioxidant pathways in ducklings

Glaesserella parasuis Infection Modulates the Transcriptome of Porcine Peritoneal Mesothelial Primary Cells: Implications for Understanding Peritoneal Invasion Mechanisms

Integrated Characterization of ceRNA (circRNA/lncRNA/miRNA/mRNA) Regulatory Networks in a Glaesserella parasuis–Induced Mouse Meningitis Model

IL-17 signaling pathway in monocytes drives the persistent inflammatory cytokine storm caused by Glaesserella parasuis infection in pigs.

黄芩苷通过抗炎机制降低猪源肠外致病性大肠杆菌感染损伤

Baicalin Alleviates Piglet Immunosuppression Induced by Glaesserella parasuis via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy

Baicalin-aluminum complexes inhibit growth and suppress virulence of enterotoxigenic Escherichia coli in vitro.

Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets

The Regulatory Role of EvfG Through Coordinated Control of Flagellar Biosynthesis and Energy Metabolism in Porcine Extraintestinal Pathogenic Escherichia coli (ExPEC)

Baicalin Alleviates ADAM17/EGFR Axis-Induced Peritonitis in Weaned Piglets Infected by Glaesserella parasuis

Comparative study of the effects of baicalin and probenecid on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Network Pharmacology to Unveil the Mechanism of Berberine in the Treatment of Streptococcus suis Meningitis in Humans and Pigs

Protective Effects of Luteolin on Glaesserella parasuis-Induced Injury: An In Vitro Study with Porcine Vascular Endothelial Cells

Baicalin Mitigates Pasteurella multocida-Induced Pulmonary and Vascular Injury via NLRP3/COX-2 Inhibition in Mice

Baicalin, Amoxicillin, and Probenecid Provide Protection in Mice Against Glaesserella parasuis Challenge

Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice

4个基因在副猪嗜血杆菌感染仔猪脑组织中DNA甲基化与mRNA表达联合验证

Using network pharmacology and molecular docking to uncover the mechanism by which quercetin alleviates deoxynivalenol-induced porcine intestinal injury.

Genomic and transcriptomics analysis reveal putative secreted proteins expressed of Pasteurella multocida during 18β-glycyrrhetinic acid treatment

PD-1/PD-L1 axis induced host immunosuppression via PI3K/Akt/mTOR signalling pathway in piglets infected by Glaesserella Parasuis

Baicalin and probenecid protect against Glaesserella parasuis challenge in a piglet model

LAMTOR1/mTORC1 promotes CD276 to induce immunosuppression via PI3K/Akt/MMP signaling pathway in Clostridium perfringens–induced necrotic enteritis of laying hens

Baicalin-aluminum complex on the regulation of IPEC-1 infected with enterotoxigenic Escherichia coli

Anemoside B4 attenuates necrotic enteritis of laying hens induced by Clostridium perfringens via inhibiting NF-κB and PI3K/Akt/mTOR signalling pathways

Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/Akt/mTOR and RAS/MEK/ERK signalling pathways

Baicalin attenuates lipopolysaccharide-induced intestinal inflammatory injury via suppressing PARP1-mediated NF-κB and NLRP3 signalling pathway.

Baicalin Weakens the Virulence of Porcine Extraintestinal Pathogenic Escherichia coli by Inhibiting the LuxS/AI-2 Quorum-Sensing System

Quercetin Protects Blood–Brain Barrier Integrity via the PI3K/Akt/Erk Signaling Pathway in a Mouse Model of Meningitis Induced by Glaesserella parasuis

Correction: Baicalin attenuates PD-1/PD-L1 axis-induced immunosuppression in piglets challenged with Glaesserella parasuis by inhibiting the PI3K/ Akt/mTOR and RAS/MEK/ERK signalling pathways

黄芩苷抑制Panx-1和P2X7的激活减轻副猪嗜血杆菌病血管内皮细胞损伤

副猪嗜血杆菌感染猪脑组织中候选基因表达水平与DNA甲基化联合分析

黄芩苷对猪源肠外致病性大肠杆菌的体内保护作用

Integrated Analysis of Long Non-Coding RNA Expression Profiles in Glaesserella parasuis-Induced Meningitis: New Insight into Pathogenesis

Baicalin Attenuated PANX-1/P2X7 Axis, P2Y6, and NLRP3/Caspase-1 Signaling Pathways in Peritonitis Induced by Glaesserella parasuis

Metagenomic Sequencing Analysis of the Effects of Acetylcysteine on the Pig Gut Microbiome

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

18β-Glycyrrhetinic Acid Alleviates P. multocida-Induced Vascular Endothelial Inflammation by PARP1-Mediated NF-κB and HMGB1 Signalling Suppression in PIEC Cells

Baicalin-aluminum alleviates necrotic enteritis in broiler chickens by inhibiting virulence factors expression of Clostridium perfringens

Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1-induced intestinal inflammatory injury.

Effects of Baicalin-Aluminum on the Virulence-Associated Traits and Virulence Genes Expression of Clostridium Perfringens

Baicalin Weakens the Porcine ExPEC-Induced Inflammatory Response in 3D4/21 Cells by Inhibiting the Expression of NF-κB/MAPK Signaling Pathways and Reducing NLRP3 Inflammasome Activation

Detection of Colistin Sulfate on Piglet Gastrointestinal Tract Microbiome Alterations

Methylome and Transcriptome-Based Integration Analysis Identified Molecular Signatures Associated With Meningitis Induced by Glaesserella parasuis

Baicalin Alleviate Apoptosis via PKC-MAPK Pathway in Porcine Peritoneal Mesothelial Cells Induced by Glaesserella parasuis

黄芩苷对仔猪感染副猪嗜血杆菌后血细胞分类计数和血液生化指标的影响

Metagenomic Sequencing Analysis of the Effects of Colistin Sulfate on the Pig Gut Microbiome

Protective Effects of Baicalin on Peritoneal Tight Junctions in Piglets Challenged with Glaesserella parasuis

Baicalin Protects Vascular Tight Junctions in Piglets During Glaesserella parasuis Infection

Baicalin-Aluminum Modulates the Broiler Gut Microbiome

Determination of Colistin in Contents Derived from Gastrointestinal Tract of Feeding Treated Piglet and Broiler

Effect of Baicalin on Transcriptome Changes in Piglet Vascular Endothelial Cells Induced by a Combination of Glaesserella parasuis and Lipopolysaccharide

黄芩苷对脂多糖诱导后仔猪生理机能的影响

黄芩苷对脂多糖诱导后仔猪血清和组织中炎性细胞因子表达的影响

The effect of baicalin on microRNA expression profiles in porcine aortic vascular endothelial cells infected by Haemophilus parasuis

The effects of baicalin on piglets challenged with Glaesserella parasuis

The Effect of Baicalin on the Expression Profiles of Long Non-Coding RNAs and mRNAs in Porcine Aortic Vascular Endothelial Cells Infected with Haemophilus parasuis

黄芩苷对副猪嗜血杆菌诱导后猪血管内皮细胞黏附分子表达的影响

黄芩苷对脂多糖诱导后仔猪的血管紧密连接蛋白表达量和MLCK-MLC的影响

Effects of Baicalin on piglet monocytes involving PKC–MAPK signaling pathways induced by Haemophilus parasuis

Pharmacokinetics of sodium baicalin following intravenous and intramuscular administration to piglets.

Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during Haemophilus parasuis invasion

Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets

Long non-coding RNA profiling in LPS-induced intestinal inflammation model: New insight into pathogenesis

Baicalin modulates NF-κB and NLRP3 inflammasome signaling in porcine aortic vascular endothelial cells Infected by Haemophilus parasuis Causing Glässer’s disease

Baicalin Inhibits Haemophilus Parasuis-Induced High-Mobility Group Box 1 Release during Inflammation

Tea polyphenols suppress growth and virulence-related factors of Haemophilus parasuis

Transcriptional Profiling of Host Cell Responses to Virulent Haemophilus parasuis: New Insights into Pathogenesis

Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model.

Combination Susceptibility Testing of Common Antimicrobials in Vitro and the Effects of Sub-MIC of Antimicrobials on Staphylococcus aureus Biofilm Formation

Comparative transcriptional profiling of tildipirosin-resistant and sensitive Haemophilus parasuis

Baicalin suppresses NLRP3 inflammasome and nuclear factor-kappa B (NF-κB) signaling during Haemophilus parasuis infection

The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

副猪嗜血杆菌反应调节因子CpxR自杀性质粒的构建

牛蒡苷元对疫苗免疫猪抗体和T细胞亚群的影响

Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence.

The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2.

Immunogenicity and protective efficacy of recombinant Haemophilus parasuis SH0165 putative outer membrane proteins.

The Live Attenuated Actinobacillus pleuropneumoniae Triple-Deletion Mutant ΔapxIC ΔapxIIC ΔapxIV-ORF1 Strain, SLW05, Immunizes Pigs against Lethal Challenge with Haemophilus parasuis