张智｜中国科学技术大学｜学者主页

2026

Auricular vagus nerve stimulation drives analgesia via an auricle–brain axis in a mouse model of neuropathic pain

Xiaoqi Peng, Yehao Liu, Yi Liu, Yunfeng Mao, Qianhui Xia, An Liu, Qian Dai, Yingju Tai, Bin Luo, Hao Wang, Yuanyin Wang, Fang Kang, Haitao Wang, Haitao Wang, Haitao Wang, Zhi Zhang

Nature Communications

DOI

2026

Author Correction: Brain regulation of gastric dysfunction induced by stress

Wanying Dong, Xia Zhu, Hao-Di Tang, Ji-Ye Huang, Mengyu Zhu, Ping‐Kai Cheng, Hao Wang, Xiyang Wang, Haitao Wang, Yu Mao, Wan Zhao, Yan Zhang, Wenjuan Tao, Zhi Zhang

Nature Metabolism

DOI

2026

Corticothalamic circuits drive voluntary physical exercise-mediated relief of surgery-induced negative emotions in mice

Ziqing He, Xiangjie Song, Ying Shi, Jing Zhou, Yuping Wang, Qingwei Wei, Dijia Wang, Liying Zhu, Qianqian Lou, Menglei Li, Xuenan Song, Chenchen Yu, Yuxue Yao, Jun Hu, Lijian Chen, Zhi Zhang, Yan Jin, Yu Mao, Guanghong Xu

Communications Biology

DOI

2026

Neural circuits for stress-induced water drinking in relief of anxiety

Lan Tang, Run-Jie Wu, Hongyu Li, Hong-Rui Wei, Jing-Bo Duan, Qianqian Lou, Le-Xian Li, Xinlu Yang, Gao W, Min Zhu, Zhi Zhang, Sen Qun, Yuanzhong Kai, Yan Jin

Proceedings of the National Academy of Sciences

DOI

2025

A neural circuit for sex-dependent conditioned pain hypersensitivity in mice

Mingjun Zhang, Ziyun Ni, Jun Ma, An Liu, Ying Liu, Qianqian Lou, Wanying Dong, Zhi Zhang, Juan Li, Peng Cao

Nature Communications

DOI

2025

Galectin-related protein, a key contributor, drives diabetes-associated neuropathic pain

Danyang Chen, Jing Wang, Xiang-Jie Song, Zijiao Ding, Qianqian Lou, Yuanyuan Chen, Mengyuan Wang, Xinlu Yang, Zhi Zhang, Juan Li, Wei Wang, Haitao Wang

Proceedings of the National Academy of Sciences

DOI

2025

G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway

Qian Meng, Meng-hui Guo, Rui Zhang, Jing Wei, Qian Chen, Xuechun Zhao, Cang‐Bao Xu, Yaoyao Wu, Jiajie Kuai, Jiemin Zhao, Yujing Wu, Chong-huan Ye, Hong-Rui Wei, Xia Zhu, Jin Yan, Zhi Zhang, Wei Wei

Acta Pharmacologica Sinica

DOI

2025

Upregulation of Acid-Sensing Ion Channel 1a in the Anterior Cingulate Cortex by TNF-α/NF-κB Pathway Contributes to Diabetes-Related Pain

Aijun Jiang, Hongrui Wei, Sijia Chu, Mengyuan Wang, Jinling Yan, Xing-Lei Song, Tian-Le Xu, Zhi Zhang, Yan Jin, Wei Wang

Diabetes

DOI

2025

Cross-modal cortical circuit for sound sensitivity in neuropathic pain

Yunfeng Mao, Mingjun Zhang, Xiaoqi Peng, Yi Liu, Yehao Liu, Qianhui Xia, Bin Luo, Lin Chen, Zhi Zhang, Yuanyin Wang, Haitao Wang

Current Biology

DOI

2024

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Xia Zhu, Ji-Ye Huang, Wanying Dong, Hao-Di Tang, Si Xu, Qielan Wu, Huimin Zhang, Ping‐Kai Cheng, Yuxin Jin, Mengyu Zhu, Wan Zhao, Yu Mao, Haitao Wang, Yan Zhang, Hao Wang, Wenjuan Tao, Yanghua Tian, Li Bai, Zhi Zhang

Nature Neuroscience

DOI

2024

Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

Danyang Chen, Qianqian Lou, Xiang-Jie Song, Fang Kang, An Liu, Changjian Zheng, Yanhua Li, Di Wang, Sen Qun, Zhi Zhang, Peng Cao, Yan Jin

Nature Communications

DOI

2024

A Neural Circuit For Bergamot Essential Oil‐Induced Anxiolytic Effects

Mengyu Zhu, Wanying Dong, Jin‐Rong Guo, Ji‐Ye Huang, Ping‐Kai Cheng, Yumeng Yang, An Liu, Xin‐Lu Yang, Xia Zhu, Zhi Zhang, Yuanyin Wang, Wenjuan Tao

Advanced Science

DOI

2024

A noradrenergic pathway for the induction of pain by sleep loss

Qianqian Lou, Hong-Rui Wei, Danyang Chen, Yuzhuo Zhang, Wanying Dong, Sen Qun, Di Wang, Yanli Luo, Zhi Zhang, Yan Jin

Current Biology

DOI

2024

A pharynx-to-brain axis controls pharyngeal inflammation–induced anxiety

Wan Zhao, Ke Zhang, Wanying Dong, Hao-Di Tang, Jiaqiang Sun, Jiaqiang Sun, Ji-Ye Huang, Guanglun Wan, Ruirui Guan, Xiao‐Tao Guo, Ping‐Kai Cheng, Ran Tao, Jingwu Sun, Jingwu Sun, Zhi Zhang, Xia Zhu

Proceedings of the National Academy of Sciences

DOI

2024

Microglial activation in the lateral amygdala promotes anxiety‐like behaviors in mice with chronic moderate noise exposure

Xiaoqi Peng, Yunfeng Mao, Yehao Liu, Qian Dai, Yingju Tai, Bin Luo, Yue Liang, Ruirui Guan, Wenjie Zhou, Lin Chen, Zhi Zhang, Guo-Ming Shen, Haitao Wang

CNS Neuroscience & Therapeutics

DOI

2024

Chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex

Danyang Chen, Liang Shen, Yu-Zhuo Zhang, Bu-Fan Kan, Qianqian Lou, Dan-dan Long, Ji-Ye Huang, Zhi Zhang, Shanshan Hu, Di Wang

British Journal of Anaesthesia

DOI

2023

Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

Jun-Ma Yu, Rui Hu, Yu Mao, Yingju Tai, Sen Qun, Zhi Zhang, Danyang Chen, Yan Jin

National Science Review

2023

A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice

Xinyue Wang, Wen-Bin Jia, Xiang Ming Xu, Rui Chen, Liangbiao Wang, Xiao-Jing Su, Pengfei Xu, Xiaoqing Liu, Xiao-Qing Liu, Jie Wen, Xiaoyuan Song, Yuanyuan Liu, Zhi Zhang, Xin-Feng Liu, Xinfeng Liu, Yan Zhang

Nature Communications

DOI

2023

Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice

Xiaoqi Peng, Yunfeng Mao, Yingju Tai, Bin Luo, Qian Dai, Xiyang Wang, Hao Wang, Yue Liang, Ruirui Guan, Chunhua Liu, Yiping Guo, Lin Chen, Zhi Zhang, Haitao Wang

Environmental Health Perspectives

DOI

2023

Brain regulation of gastric dysfunction induced by stress

Wanying Dong, Xia Zhu, Hao-Di Tang, Ji-Ye Huang, Mengyu Zhu, Ping‐Kai Cheng, Hao Wang, Xiyang Wang, Haitao Wang, Yu Mao, Wan Zhao, Yan Zhang, Wenjuan Tao, Zhi Zhang

Nature Metabolism

DOI

2023

Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain

Xiang-Jie Song, Chen-Ling Yang, Danyang Chen, Yumeng Yang, Yu Mao, Peng Cao, Aijun Jiang, Wei Wang, Zhi Zhang, Wenjuan Tao

Frontiers in Cellular Neuroscience

DOI

2023

Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia

Liangbiao Wang, Xiaojing Su, Jinjin Yan, Qiaofeng Wu, Xiang Ming Xu, Xinyue Wang, Xiaoqing Liu, Xiaoqing Liu, Xiaoyuan Song, Zhi Zhang, Wei Hu, Xinfeng Liu, Xinfeng Liu, Yan Zhang

iScience

DOI

2023

A central amygdala input to the dorsal vagal complex controls gastric motility in mice under restraint stress

Hao Wang, Wen-Jian Liu, Xiyang Wang, Xiaoqi Chen, Rong-Lin Cai, Meng-Ting Zhang, Haitao Wang, Guangwei He, Zhi Zhang, Guo-Ming Shen

Frontiers in Physiology

DOI

2023

Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice

Zihua Song, Xiang-Jie Song, Chen-Ling Yang, Peng Cao, Yu Mao, Yan Jin, Mengyun Xu, Haitao Wang, Xia Zhu, Wei Wang, Zhi Zhang, Wenjuan Tao

Acta Pharmacologica Sinica

DOI

2022

Sound induces analgesia through corticothalamic circuits

Wenjie Zhou, Chonghuan Ye, Haitao Wang, Yu Mao, Weijia Zhang, An Liu, Chen-Ling Yang, Tianming Li, Lauren Hayashi, Wan Zhao, Lin Chen, Yuanyuan Liu, Wenjuan Tao, Zhi Zhang

Science

DOI

2022

A neural circuit for the suppression of feeding under persistent pain

Hao-Di Tang, Wanying Dong, Rui Min Hu, Ji-Ye Huang, Zhaohuan Huang, Wei Xiong, Tian Xue, Ji Liu, Jun‐Ma Yu, Xia Zhu, Zhi Zhang

Nature Metabolism

DOI

2022

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Xiaojing Meng, Lingxiao Yue, An Liu, Wenjuan Tao, Li Shi, Wan Zhao, Zhongmin Wu, Zhi Zhang, Liecheng Wang, Xulai Zhang, Wenjie Zhou

Journal of Biological Chemistry

DOI

2022

Deciphering neural circuits mediating sound-induced analgesia

Wenjie Zhou, Zhi Zhang

《动物学研究》

DOI

2021

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

Peng Cao, Changmao Chen, An Liu, Qing‐Hong Shan, Xia Zhu, Chun-Hui Jia, Xiaoqi Peng, Mingjun Zhang, Zahra Farzinpour, Wenjie Zhou, Haitao Wang, Jiang‐Ning Zhou, Xiaoyuan Song, Liecheng Wang, Wenjuan Tao, Changjian Zheng, Yan Zhang, Yu‐Qiang Ding, Yan Jin, Lin Xu, Zhi Zhang

Neuron

DOI

2021

Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Xia Zhu, Hao-Di Tang, Wanying Dong, Fang Kang, An Liu, Yu Mao, Wen Xie, Xulai Zhang, Peng Cao, Wenjie Zhou, Haitao Wang, Zahra Farzinpour, Wenjuan Tao, Xiaoyuan Song, Yan Zhang, Tian Xue, Yan Jin, Juan Li, Zhi Zhang

Nature Neuroscience

DOI

2021

Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain

Wenjie Zhou, Yanhua Li, Xiaojing Meng, An Liu, Yu Mao, Xia Zhu, Qian Meng, Yan Jin, Zhi Zhang, Wenjuan Tao

Journal of Biological Chemistry

DOI

2020

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

Kai An, Huan Zhao, Ying Miao, Qi Xu, Yufei Li, Yuqian Ma, Yiming Shi, Jiawei Shen, Jian-Jun Meng, Yong‐Gang Yao, Zhi Zhang, Jutao Chen, Jin Bao, Mei Zhang, Tian Xue

Nature Neuroscience

DOI

2020

MeCP2 mediates transgenerational transmission of chronic pain

Wenjuan Tao, Changmao Chen, Yu‐Ping Wang, Wenjie Zhou, Yan Jin, Yu Mao, Haitao Wang, Likui Wang, Wen Jun Xie, Xulai Zhang, Jie Li, Juan Li, Xiang‐Yao Li, Zhen-Quan Tang, Chenghua Zhou, Zhizhong Z. Pan, Zhi Zhang

Progress in Neurobiology

DOI

2020

A Central Amygdala–Ventrolateral Periaqueductal Gray Matter Pathway for Pain in a Mouse Model of Depression-like Behavior

Weiwei Yin, Lisheng Mei, Tingting Sun, Yuping Wang, Jie Li, Changmao Chen, Zahra Farzinpour, Yu Mao, Wenjuan Tao, Juan Li, Wen Xie, Zhi Zhang

Anesthesiology

DOI

2019

A Central Amygdala Input to the Parafascicular Nucleus Controls Comorbid Pain in Depression

Xia Zhu, Wenjie Zhou, Yan Jin, Hao-Di Tang, Peng Cao, Yu Mao, Wen Xie, Xulai Zhang, Fei Zhao, Min-Hua Luo, Haitao Wang, Jie Li, Wenjuan Tao, Zahra Farzinpour, Likui Wang, Xiang‐Yao Li, Juan Li, Zheng-Quan Tang, Chenghua Zhou, Zhizhong Z. Pan, Zhi Zhang

Cell Reports

DOI

2019

A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain

Yan Jin, Qian Meng, Lisheng Mei, Wenjie Zhou, Xia Zhu, Yu Mao, Wen Xie, Xulai Zhang, Min‐Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Xiang‐Yao Li, Zhi Zhang

Pain

DOI

2019

Publisher Correction: A neural circuit for comorbid depressive symptoms in chronic pain

Wenjie Zhou, Yan Jin, Qian Meng, Xia Zhu, Tongjian Bai, Yanghua Tian, Yu Mao, Likui Wang, Wen Xie, Hui Zhong, Na Zhang, Min‐Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Bensheng Qiu, Jiang‐Ning Zhou, Xiang‐Yao Li, Han Xu, Kai Wang, Xiaochu Zhang, Yong Liu, Gal Richter‐Levin, Lin Xu, Zhi Zhang

Nature Neuroscience

DOI

2019

A neural circuit for comorbid depressive symptoms in chronic pain

Wenjie Zhou, Yan Jin, Qian Meng, Xia Zhu, Tongjian Bai, Yanghua Tian, Yu Mao, Likui Wang, Wen Xie, Hui Zhong, Na Zhang, Min‐Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Bensheng Qiu, Jiang‐Ning Zhou, Xiang‐Yao Li, Xu Han, Kai Wang, Xiaochu Zhang, Yong Liu, Gal Richter‐Levin, Lin Xu, Zhi Zhang

Nature Neuroscience

DOI

2019

Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain

Yuping Wang, Peng Cao, Lisheng Mei, Weiwei Yin, Yu Mao, Chaoshi Niu, Zhi Zhang, Wenjuan Tao

Neuroscience

DOI

2019

Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats

Yu Mao, Jing Zhou, Xuesheng Liu, Erwei Gu, Zhi Zhang, Wenjuan Tao

Pain Research and Management

DOI

2019

Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior

Haitao Wang, Jiahui Chen, Xiaotong Xu, Wenjian Sun, Xi Chen, Fei Zhao, Min‐Hua Luo, Chunhua Liu, Yiping Guo, Wen Xie, Hui Zhong, Tongjian Bai, Yanghua Tian, Yu Mao, Chonghuan Ye, Wenjuan Tao, Jie Li, Zahra Farzinpour, Juan Li, Jiang‐Ning Zhou, Kai Wang, Jufang He, Lin Chen, Zhi Zhang

PLoS Biology

DOI

2016

Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain

Wenjuan Tao, Wenjie Zhou, Yuping Wang, Tingting Sun, Haitao Wang, Zhi Zhang, Yan Jin

Neuroscience

DOI

2015

Beneficial effects of enriched environment on behaviors were correlated with decreased estrogen and increased BDNF in the hippocampus of male mice.

Fantao Meng, Jun Zhao, Rong‐Jun Ni, Hui Fang, Lifeng Zhang, Zhi Zhang, Ya-Jing Liu

PubMed

2014

MeCP2 Repression of G9a in Regulation of Pain and Morphine Reward

Zhi Zhang, W. Tao, Y.-Y. Hou, Weidong Wang, Paul J. Kenny, Zhizhong Z. Pan

Journal of Neuroscience

DOI

2014

Persistent Inflammation-induced Up-regulation of Brain-derived Neurotrophic Factor (BDNF) Promotes Synaptic Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor GluA1 Subunits in Descending Pain Modulatory Circuits

Wenjuan Tao, Quan Chen, Wenjie Zhou, Yunping Wang, Lu Wang, Zhi Zhang

Journal of Biological Chemistry

DOI

2011

抑制雌激素的生物合成会引起C57BL/6J卵巢摘除小鼠的轻微焦虑样行为(英文)

孟凡涛，倪荣军，张智，赵君，刘雅静，周江宁

Neuroscience Bulletin

2011

Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice

Fantao Meng, Rong‐Jun Ni, Zhi Zhang, Jun Jie Zhao, Ya-Jing Liu, Jiang‐Ning Zhou

Neuroscience Bulletin

DOI

精选作品

期刊论文

Auricular vagus nerve stimulation drives analgesia via an auricle–brain axis in a mouse model of neuropathic pain

Author Correction: Brain regulation of gastric dysfunction induced by stress

Corticothalamic circuits drive voluntary physical exercise-mediated relief of surgery-induced negative emotions in mice

Neural circuits for stress-induced water drinking in relief of anxiety

A neural circuit for sex-dependent conditioned pain hypersensitivity in mice

Galectin-related protein, a key contributor, drives diabetes-associated neuropathic pain

G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway

Upregulation of Acid-Sensing Ion Channel 1a in the Anterior Cingulate Cortex by TNF-α/NF-κB Pathway Contributes to Diabetes-Related Pain

Cross-modal cortical circuit for sound sensitivity in neuropathic pain

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

A Neural Circuit For Bergamot Essential Oil‐Induced Anxiolytic Effects

A noradrenergic pathway for the induction of pain by sleep loss

A pharynx-to-brain axis controls pharyngeal inflammation–induced anxiety

Microglial activation in the lateral amygdala promotes anxiety‐like behaviors in mice with chronic moderate noise exposure

Chronic nicotine exposure elicits pain hypersensitivity through activation of dopaminergic projections to anterior cingulate cortex

Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

A glutamatergic DRN–VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice

Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice

Brain regulation of gastric dysfunction induced by stress

Up-regulation of LCN2 in the anterior cingulate cortex contributes to neural injury-induced chronic pain

Involvement of Mrgprd-expressing nociceptors-recruited spinal mechanisms in nerve injury-induced mechanical allodynia

A central amygdala input to the dorsal vagal complex controls gastric motility in mice under restraint stress

Up-regulation of microglial chemokine CXCL12 in anterior cingulate cortex mediates neuropathic pain in diabetic mice

Sound induces analgesia through corticothalamic circuits

A neural circuit for the suppression of feeding under persistent pain

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Deciphering neural circuits mediating sound-induced analgesia

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states

Switching of delta opioid receptor subtypes in central amygdala microcircuits is associated with anxiety states in pain

A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice

MeCP2 mediates transgenerational transmission of chronic pain

A Central Amygdala–Ventrolateral Periaqueductal Gray Matter Pathway for Pain in a Mouse Model of Depression-like Behavior

A Central Amygdala Input to the Parafascicular Nucleus Controls Comorbid Pain in Depression

A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain

Publisher Correction: A neural circuit for comorbid depressive symptoms in chronic pain

A neural circuit for comorbid depressive symptoms in chronic pain

Microglia in the Primary Somatosensory Barrel Cortex Mediate Trigeminal Neuropathic Pain

Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats

Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior

Histone deacetylase inhibitor-induced emergence of synaptic δ-opioid receptors and behavioral antinociception in persistent neuropathic pain

Beneficial effects of enriched environment on behaviors were correlated with decreased estrogen and increased BDNF in the hippocampus of male mice.

MeCP2 Repression of G9a in Regulation of Pain and Morphine Reward

Persistent Inflammation-induced Up-regulation of Brain-derived Neurotrophic Factor (BDNF) Promotes Synaptic Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor GluA1 Subunits in Descending Pain Modulatory Circuits

抑制雌激素的生物合成会引起C57BL/6J卵巢摘除小鼠的轻微焦虑样行为(英文)

Inhibition of oestrogen biosynthesis induces mild anxiety in C57BL/6J ovariectomized female mice

会议论文

疼痛伴抑郁的环路机制

中缝背核到中央杏仁核5-HT能神经环路在慢性痛伴抑郁症中的研究

持续炎性上调BDNF促使AMPA受体GluA1亚基迁移上膜

预印本

Hypothalamus-Sympathetic-Liver Axis Mediates the Early Phase of Stress-Induced Hyperglycemia

Dexmedetomidine Alleviates Anxiety-Like Behavior in Mice Following Peripheral Nerve Injury by Reducing the Hyperactivity of Glutamatergic Neurons in the Anterior Cingulate Cortex

Single-cell RNA sequencing uncovers the excitatory/inhibitory synaptic unbalance in the retrosplenial cortex after peripheral nerve injury

书籍章节

Pain-Induced Chromatin Modifications

研究方向